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[PMID]:28942280
[Au] Autor:Edwards TM; Hamlin HJ; Freymiller H; Green S; Thurman J; Guillette LJ
[Ad] Endereço:Department of Biology, University of the South, Sewanee, TN, USA; Department of Biology, University of Florida, Gainesville, FL, USA; School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA. Electronic address: theamedwards@gmail.com.
[Ti] Título:Nitrate induces a type 1 diabetic profile in alligator hatchlings.
[So] Source:Ecotoxicol Environ Saf;147:767-775, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1 in 300 children by age 18. T1D is caused by inflammation-induced loss of insulin-producing pancreatic beta cells, leading to high blood glucose and a host of downstream complications. Although multiple genes are associated with T1D risk, only 5% of genetically susceptible individuals actually develop clinical disease. Moreover, a growing number of T1D cases occur in geographic clusters and among children with low risk genotypes. These observations suggest that environmental factors contribute to T1D etiology. One potential factor, supported primarily by epidemiological studies, is the presence of nitrate and nitrite in drinking water. To test this hypothesis, female hatchling alligators were exposed to environmentally relevant concentrations of nitrate in their tank water (reference, 10mg/L, or 100mg/L NO -N) from hatch through 5 weeks or 5 months of age. At each time point, endpoints related to T1D were investigated: plasma levels of glucose, triglycerides, testosterone, estradiol, and thyroxine; pancreas, fat body, and thyroid weights; weight gain or loss; presence of immune cells in the pancreas; and pancreatic beta cell number, assessed by antibody staining of nkx6.1 protein. Internal dosing of nitrate was confirmed by measuring plasma and urine nitrate levels and whole blood methemoglobin. Cluster analysis indicated that high nitrate exposure (most animals exposed to 100mg/L NO3-N and one alligator exposed to 10mg/L NO3-N) induced a profile of endpoints consistent with early T1D that could be detected after 5 weeks and was more strongly present after 5 months. Our study supports epidemiological data correlating elevated nitrate with T1D onset in humans, and highlights nitrate as a possible environmental contributor to the etiology of T1D, possibly through its role as a nitric oxide precursor.
[Mh] Termos MeSH primário: Jacarés e Crocodilos/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Tipo 1/induzido quimicamente
Disruptores Endócrinos/toxicidade
Nitratos/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Jacarés e Crocodilos/crescimento & desenvolvimento
Animais
Glicemia/análise
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Tipo 1/sangue
Relação Dose-Resposta a Droga
Disruptores Endócrinos/farmacocinética
Monitoramento Ambiental/métodos
Feminino
Hormônios Esteroides Gonadais/sangue
Nitratos/farmacocinética
Tamanho do Órgão/efeitos dos fármacos
Tiroxina/sangue
Triglicerídeos/sangue
Poluentes Químicos da Água/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Endocrine Disruptors); 0 (Gonadal Steroid Hormones); 0 (Nitrates); 0 (Triglycerides); 0 (Water Pollutants, Chemical); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:29180865
[Au] Autor:Zeng D; Zhang X; Wang X; Cao L; Zheng A; Du J; Li Y; Huang Q; Jiang X
[Ad] Endereço:Department of Prosthodontics, School of Medicine, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China.
[Ti] Título:Fabrication of large-pore mesoporous Ca-Si-based bioceramics for bone regeneration.
[So] Source:Int J Nanomedicine;12:8277-8287, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Our previous study revealed that mesoporous Ca-Si-based materials exhibited excellent osteoconduction because dissolved ions could form a layer of hydroxycarbonate apatite on the surface of the materials. However, the biological mechanisms underlying bone regeneration were largely unknown. The main aim of this study was to evaluate the osteogenic ability of large-pore mesoporous Ca-Si-based bioceramics (LPMSCs) by alkaline phosphatase assay, real-time PCR analysis, von Kossa, and alizarin red assay. Compared with large-pore mesoporous silica (LPMS), LPMSCs had a better effect on the osteogenic differentiation of dental pulp cells. LPMSC-2 and LPMSC-3 with higher calcium possessed better osteogenic abilities than LPMSC-1, which may be related to the calcium-sensing receptor pathway. Furthermore, the loading capacity for recombinant human platelet-derived growth factor-BB was satisfactory in LPMSCs. In vivo, the areas of new bone formation in the calvarial defect repair were increased in the LPMSC-2 and LPMSC-3 groups compared with the LPMSC-1 and LPMS groups. We concluded that LPMSC-2 and LPMSC-3 possessed both excellent osteogenic abilities and satisfactory loading capacities, which may be attributed to their moderate Ca/Si molar ratio. Therefore, LPMSCs with moderate Ca/Si molar ratio might be potential alterative grafts for craniomaxillofacial bone regeneration.
[Mh] Termos MeSH primário: Regeneração Óssea/fisiologia
Cálcio/química
Teste de Materiais/métodos
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Antraquinonas/análise
Antraquinonas/metabolismo
Materiais Biocompatíveis/química
Compostos de Cálcio/química
Diferenciação Celular
Cerâmica/química
Polpa Dentária/citologia
Seres Humanos
Masculino
Naftalenos/farmacologia
Nitratos/química
Osteogênese/efeitos dos fármacos
Fator de Crescimento Derivado de Plaquetas/genética
Fator de Crescimento Derivado de Plaquetas/metabolismo
Porosidade
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Crânio/lesões
Crânio/fisiologia
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Biocompatible Materials); 0 (Calcium Compounds); 0 (N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine); 0 (Naphthalenes); 0 (Nitrates); 0 (Platelet-Derived Growth Factor); 3F3AT0Q12H (Alizarin Red S); 7631-86-9 (Silicon Dioxide); EC 3.1.3.1 (Alkaline Phosphatase); NF52F38N1N (calcium nitrate); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S144528


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[PMID]:28968514
[Au] Autor:Huang Y; Li P; Chen G; Peng L; Chen X
[Ad] Endereço:Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Sciences, East China Normal University, No.500 Dong Chuan Road, Shanghai 200241, PR China.
[Ti] Título:The production of cyanobacterial carbon under nitrogen-limited cultivation and its potential for nitrate removal.
[So] Source:Chemosphere;190:1-8, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Harmful cyanobacterial blooms (CyanoHABs) represent a serious threat to aquatic ecosystems. A beneficial use for these harmful microorganisms would be a promising resolution of this urgent issue. This study applied a simple method, nitrogen limitation, to cultivate cyanobacteria aimed at producing cyanobacterial carbon for denitrification. Under nitrogen-limited conditions, the common cyanobacterium, Microcystis, efficiently used nitrate, and had a higher intracellular C/N ratio. More importantly, organic carbons easily leached from its dry powder; these leachates were biodegradable and contained a larger amount of dissolved organic carbon (DOC) and carbohydrates, but a smaller amount of dissolved total nitrogen (DTN) and proteins. When applied to an anoxic system with a sediment-water interface, a significant increase of the specific NO -N removal rate was observed that was 14.2 times greater than that of the control. This study first suggests that nitrogen-limited cultivation is an efficient way to induce organic and carbohydrate accumulation in cyanobacteria, as well as a high C/N ratio, and that these cyanobacteria can act as a promising carbon source for denitrification. The results indicate that application as a carbon source is not only a new way to utilize cyanobacteria, but it also contributes to nitrogen removal in aquatic ecosystems, further limiting the proliferation of CyanoHABs.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Carbono/metabolismo
Cianobactérias/metabolismo
Desnitrificação
Nitratos/isolamento & purificação
Nitrogênio/deficiência
[Mh] Termos MeSH secundário: Ecossistema
Microcystis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 7440-44-0 (Carbon); N762921K75 (Nitrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


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[PMID]:29199992
[Au] Autor:Oulavallickal T; Brewster JL; McKellar JLO; Fairhurst MJ; Tenci NA; Gerth ML
[Ad] Endereço:Department of Biochemistry, University of Otago, PO Box 56, Dunedin, Otago 9054, New Zealand.
[Ti] Título:The Pseudomonas syringae pv. actinidiae chemoreceptor protein F (PscF) periplasmic sensor domain: cloning, purification and X-ray crystallographic analysis.
[So] Source:Acta Crystallogr F Struct Biol Commun;73(Pt 12):701-705, 2017 Dec 01.
[Is] ISSN:2053-230X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrate- and nitrite-sensing (NIT) domains are found associated with a wide variety of bacterial receptors, including chemoreceptors. However, the structure of a chemoreceptor-associated NIT domain has not yet been characterized. Recently, a chemoreceptor named PscF was identified from the plant pathogen Pseudomonas syringae pv. actinidiae that is predicted to contain a periplasmic NIT domain. The PscF sensor domain (PscF-SD; residues 42-332) was cloned into an appropriate expression vector, recombinantly produced in Escherichia coli BL21-Gold(DE3) cells and purified via immobilized metal-affinity and size-exclusion chromatography. Purified PscF-SD was screened for crystallization; the best crystal diffracted to a maximum resolution of 1.46 Šin space group P2 2 2 . However, the data could not be phased using the only available NIT-domain structure (Klebsiella oxytoca NasR; PDB entry 4akk) as the search model. Therefore, a data set from a selenomethionine-labelled protein crystal was also collected. The selenomethionine-labelled protein crystal diffracted to a resolution of 2.46 Šin space group P2 2 2 . These data will be used to attempt to solve the structure using the single-wavelength anomalous diffraction technique. The structure is expected to provide insights into the ligand specificity of NIT domains and the role of NIT domains in chemotaxis.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Pseudomonas syringae/química
[Mh] Termos MeSH secundário: Proteínas de Bactérias/isolamento & purificação
Fatores Quimiotáticos
Cromatografia de Afinidade
Cromatografia em Gel
Clonagem Molecular
Cristalografia por Raios X
Nitratos/química
Nitratos/metabolismo
Nitritos/química
Nitritos/metabolismo
Periplasma/metabolismo
Domínios Proteicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Chemotactic Factors); 0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1107/S2053230X17016831


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[PMID]:28743592
[Au] Autor:Cronin AA; Odagiri M; Arsyad B; Nuryetty MT; Amannullah G; Santoso H; Darundiyah K; Nasution N'
[Ad] Endereço:UNICEF Indonesia, World Trade Center 6 (10th Floor), Jalan Jenderal Sudirman Kav. 31, Jakarta 12920, Indonesia. Electronic address: acronin@unicef.org.
[Ti] Título:Piloting water quality testing coupled with a national socioeconomic survey in Yogyakarta province, Indonesia, towards tracking of Sustainable Development Goal 6.
[So] Source:Int J Hyg Environ Health;220(7):1141-1151, 2017 10.
[Is] ISSN:1618-131X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:There remains a pressing need for systematic water quality monitoring strategies to assess drinking water safety and to track progress towards the Sustainable Development Goals (SDG). This study incorporated water quality testing into an existing national socioeconomic survey in Yogyakarta province, Indonesia; the first such study in Indonesia in terms of SDG tracking. Multivariate regression analysis assessed the association between faecal and nitrate contamination and drinking water sources household drinking water adjusted for wealth, education level, type of water sources and type of sanitation facilities. The survey observed widespread faecal contamination in both sources for drinking water (89.2%, 95%CI: 86.9-91.5%; n=720) and household drinking water (67.1%, 95%CI: 64.1-70.1%; n=917) as measured by Escherichia coli. This was despite widespread improved drinking water source coverage (85.3%) and commonly self-reported boiling practices (82.2%). E.coli concentration levels in household drinking water were associated with wealth, education levels of a household head, and type of water source (i.e. vender water or local sources). Following the proposed SDG definition for Target 6.1 (water) and 6.2 (sanitation), the estimated proportion of households with access to safely managed drinking water and sanitation was 8.5% and 45.5%, respectively in the study areas, indicating substantial difference from improved drinking water (82.2%) and improved sanitation coverage (70.9%) as per the MDGs targets. The greatest contamination and risk factors were found in the poorest households indicating the urgent need for targeted and effective interventions here. There is suggested evidence that sub-surface leaching from on-site sanitation adversely impacts on drinking water sources, which underscores the need for further technical assistance in promoting latrine construction. Urgent action is still needed to strengthen systematic monitoring efforts towards tracking SDG Goal 6.
[Mh] Termos MeSH primário: Água Potável/microbiologia
Escherichia coli/isolamento & purificação
Poluentes Químicos da Água/análise
Qualidade da Água
[Mh] Termos MeSH secundário: Cloretos/análise
Conservação dos Recursos Naturais
Água Potável/análise
Fezes/microbiologia
Metas
Seres Humanos
Indonésia
Nitratos/análise
Pobreza
Análise de Regressão
Saneamento/métodos
Fatores Socioeconômicos
Inquéritos e Questionários
Microbiologia da Água
Abastecimento de Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 0 (Drinking Water); 0 (Nitrates); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:29406116
[Au] Autor:Nguyen TN; Chen PC; Huang C
[Ad] Endereço:Institute of Environmental Engineering, National Chiao Tung University, Hsinchu 300, Chinese Taipei.
[Ti] Título:Nitrate removal and extracellular polymeric substances of autohydrogenotrophic bacteria under various pH and hydrogen flow rates.
[So] Source:J Environ Sci (China);63:50-57, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In recent years there has been an increasing interest in the use of autohydrogenotrophic bacteria to treat nitrate from wastewater. However, our knowledge about the characteristics of extracellular polymeric substances (EPS) releasing by these activities is not yet very advanced. This study aimed to investigate the change in EPS compositions under various pH values and hydrogen flow rates, taking into consideration nitrogen removal. Results showed that pH7.5 and a hydrogen flow rate of 90mL/min were the optimal operating conditions, resulting in 100% nitrogen removal after 6hr of operation. Soluble and bound polysaccharides decreased, while bound proteins increased with increasing pH. Polysaccharides increased with increasing hydrogen flow rate. No significant change of bound proteins was observed at various hydrogen flow rates.
[Mh] Termos MeSH primário: Polissacarídeos Bacterianos/química
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
[Mh] Termos MeSH secundário: Bactérias
Hidrogênio/química
Concentração de Íons de Hidrogênio
Nitratos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Polysaccharides, Bacterial); 0 (Waste Water); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:27779565
[Au] Autor:Son WM; Sung KD; Cho JM; Park SY
[Ad] Endereço:1Department of Ocean Physical Education, National Korea Maritime and Ocean University, Busan, Korea 2Department of Physical Education, Pusan National University, Busan, Korea 3Department of Exercise and Sport Science, The University of Utah, Salt Lake City, UT 4Department of Cardiology, Boston University School of Medicine, Boston, MA.
[Ti] Título:Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension.
[So] Source:Menopause;24(3):262-268, 2017 Mar.
[Is] ISSN:1530-0374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Postmenopausal women exhibit elevated brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, which is associated with an increased risk of cardiovascular events and mortality. The purpose of this study is to examine the impact of combined resistance and aerobic exercise training on baPWV, blood pressure (BP), and cardiovascular fitness in postmenopausal women with stage 1 hypertension. METHODS: Twenty postmenopausal women (age, 75 ±â€Š2 y; systolic BP, 152 ±â€Š2 mm Hg, diastolic BP, 95 ±â€Š3 mm Hg) were randomly assigned to a "no-exercise" (CON, n = 10) or combined exercise (EX, n = 10) group. The EX group performed resistance and aerobic exercise for 12 weeks, 3 times per week. Exercise intensity was increased gradually, from 40% to 70% of heart rate reserve, every 4 weeks. BaPWV, BP, blood nitrite/nitrate, endothelin-1 (ET-1), cardiovascular fitness, and body composition were measured before and after the 12-week intervention. RESULTS: BP, baPWV (-1.2 ±â€Š0.4 m/s), ET-1 (-2.7 ±â€Š0.3 µmol/mL), nitrite/nitrate (+4.5 ±â€Š0.5 µM), functional capacity, and body composition were significantly improved (P < 0.05) in the EX group after 12 weeks of training, but no changes were observed in the CON group. CONCLUSIONS: These findings indicate that 12 weeks of combined exercise training improves arterial stiffness, BP, ET-1, blood nitrite/nitrate, functional capacity, and body composition in postmenopausal women with stage 1 hypertension. Thus, this study provides evidence that combined exercise training is a useful therapeutic method to improve cardiovascular health which can reduce cardiovascular disease risk in postmenopausal women with hypertension.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Hipertensão/terapia
Pós-Menopausa
Treinamento de Resistência/métodos
Rigidez Vascular/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Índice Tornozelo-Braço
Biomarcadores/sangue
Composição Corporal
Doenças Cardiovasculares/etiologia
Exercício/fisiologia
Feminino
Seres Humanos
Hipertensão/complicações
Hipertensão/fisiopatologia
Nitratos/sangue
Nitritos/sangue
Pós-Menopausa/sangue
Análise de Onda de Pulso
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1097/GME.0000000000000765


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[PMID]:29374975
[Au] Autor:Wang B; Liu T; Wu Z; Zhang L; Sun J; Wang X
[Ad] Endereço:a School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , China.
[Ti] Título:Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents.
[So] Source:J Enzyme Inhib Med Chem;33(1):416-423, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested in vitro activity, including α-glucosidase inhibitory activity, aldose reductase (AR) inhibitory activity and advanced glycation end products (AGEs) formation inhibitory activity. A class of modified compounds could play a significant effect for treatment of diabetic complications. Target compounds 3e and 7c offered a potential drug design concept for the development of therapeutic or preventive agents for diabetes and its complications.
[Mh] Termos MeSH primário: Complicações do Diabetes/tratamento farmacológico
Diabetes Mellitus Experimental/tratamento farmacológico
Inibidores Enzimáticos/farmacologia
Hipoglicemiantes/farmacologia
Nitratos/farmacologia
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Aldeído Redutase/antagonistas & inibidores
Aldeído Redutase/metabolismo
Animais
Complicações do Diabetes/metabolismo
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/metabolismo
Relação Dose-Resposta a Droga
Desenho de Drogas
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Produtos Finais de Glicação Avançada/antagonistas & inibidores
Produtos Finais de Glicação Avançada/metabolismo
Hipoglicemiantes/síntese química
Hipoglicemiantes/química
Camundongos
Camundongos Endogâmicos
Estrutura Molecular
Nitratos/química
Óxido Nítrico/metabolismo
Estilbenos/síntese química
Estilbenos/química
Estreptozocina
Relação Estrutura-Atividade
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Glycation End Products, Advanced); 0 (Hypoglycemic Agents); 0 (Nitrates); 0 (Stilbenes); 31C4KY9ESH (Nitric Oxide); 5W494URQ81 (Streptozocin); EC 1.1.1.21 (Aldehyde Reductase); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1425686


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[PMID]:29117591
[Au] Autor:Zhai S; Ji M; Zhao Y; Pavlostathis SG; Zhao Q
[Ad] Endereço:School of Environmental Science and Engineering, Tianjin University, Tianjin 300350, China; School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0512, United States.
[Ti] Título:Effects of salinity and COD/N on denitrification and bacterial community in dicyclic-type electrode based biofilm reactor.
[So] Source:Chemosphere;192:328-336, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A dicyclic-type electrode based biofilm electrode reactor (BER) was developed for advanced nitrate removal from saline municipal wastewater. The denitrification efficiency was evaluated with a synthetic feed (NO -N, 20 mg L ) under different salinity and COD to nitrogen ratios (COD/N). As the salinity increased from 0% to 1.0%, the denitrification performance of both the traditional biofilm reactor (BR) and BER was inhibited; however, the BER showed better adaptation and ability to recover. The BER achieved a high nitrate removal efficiency (≥90%) at a salinity of 1.0% and a low COD/N of 2.5 (theoretical stoichiometric 2.86 ignoring microbial growth). The abundance of Methylotenera mobilis in BR and Clostridium sticklandii in BER was higher than in the initial sludge sample used as inoculum. Likewise, the abundance of napA, nirS and nosZ genes increased as the COD/N further decreased. Under high salinity stress, the BER had a higher denitrification efficiency and the consumption of the organic carbon source (i.e., methanol) was reduced compared to BR. The cooperation between heterotrophic and autotrophic denitrifiers in the BER system provides a more efficient and feasible solution for nitrate removal from saline municipal wastewater.
[Mh] Termos MeSH primário: Biofilmes
Reatores Biológicos/microbiologia
Desnitrificação
Salinidade
[Mh] Termos MeSH secundário: Processos Autotróficos
Reatores Biológicos/normas
Processos Heterotróficos
Nitratos/isolamento & purificação
Nitrogênio/análise
Esgotos/microbiologia
Águas Residuais/química
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Sewage); 0 (Waste Water); N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171109
[St] Status:MEDLINE


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[PMID]:28921575
[Au] Autor:Quist AJL; Inoue-Choi M; Weyer PJ; Anderson KE; Cantor KP; Krasner S; Freeman LEB; Ward MH; Jones RR
[Ad] Endereço:Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
[Ti] Título:Ingested nitrate and nitrite, disinfection by-products, and pancreatic cancer risk in postmenopausal women.
[So] Source:Int J Cancer;142(2):251-261, 2018 Jan 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986-2011). We used historical monitoring and treatment data to estimate levels of long-term average nitrate and total trihalomethanes (TTHM; the sum of the most prevalent DBP class) and the duration exceeding one-half the maximum contaminant level (>½ MCL; 5 mg/L nitrate-nitrogen, 40 µg/L TTHM) among participants on public water supplies (PWS) >10 years. We estimated dietary nitrate and nitrite intakes using a food frequency questionnaire. We computed hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression and evaluated nitrate interactions with smoking and vitamin C intake. We identified 313 cases among 34,242 women, including 152 with >10 years PWS use (N = 15,710). Multivariable models of average nitrate showed no association with pancreatic cancer (HR = 1.16, 95% CI: 0.51-2.64). Associations with average TTHM levels were also null (HR = 0.70, 95% CI:0.42-1.18). We observed no trend with increasing years of exposure to either contaminant at levels >½ MCL. Positive associations were suggested in the highest dietary nitrite intake from processed meat (HR = 1.66, 95% CI 1.00-2.75;p = 0.05). We found no interactions of nitrate with known modifiers of endogenous NOC formation. Our results suggest that nitrite intake from processed meat may be a risk factor for pancreatic cancer.
[Mh] Termos MeSH primário: Desinfecção/métodos
Nitratos/efeitos adversos
Nitritos/efeitos adversos
Neoplasias Pancreáticas/etiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seguimentos
Seres Humanos
Iowa
Meia-Idade
Estadiamento de Neoplasias
Pós-Menopausa
Prognóstico
Estudos Prospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.31055



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