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[PMID]:28278777
[Au] Autor:Lu YF; Ma LJ; Ma L; Shan B; Chang JJ
[Ad] Endereço:a School of Ecology and Environmental Science, Yunnan University , Kunming , People's Republic of China.
[Ti] Título:Improvement of start-up and nitrogen removal of the anammox process in reactors inoculated with conventional activated sludge using biofilm carrier materials.
[So] Source:Environ Technol;39(1):59-67, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The start-up of the anaerobic ammonium oxidation (anammox) process in three up-flow column reactors seeded with common mixed activated sludge and added with three materials, sponge (R1), sponge + volcanic rock (R2) and sponge + charcoal (R3), as carriers for biofilm formation were comparatively investigated in this study. The supplement of volcanic rock and charcoal could significantly shorten the start-up time of the anammox process, which primarily occurred in the activity-enhanced phase, with ammonium and nitrite removal efficiencies stabilized above 92.5% and 93.4% after an operation period of 145, 105 and 121 d for R1, R2 and R3, respectively. After the successful anammox start-up, R2 performed significantly better in TN removal (p < .05), achieving an average rate of 91.0% and 191.5 g N m d compared to R1 of 88.4% and 172.1 g N m d , and R3 of 89.9% and 180.1 g N m d in the steady running phase. The ratios of consumed [Formula: see text] and generated [Formula: see text]/consumed [Formula: see text] after anammox start-up were lower than the theoretical values, probably suggesting the simultaneous existences of anammox, denitrification as well as nitrification processes in the reactors. A reddish brown biofilm was wrapped on the carriers and morphological detection of biofilm displayed the presentations of thick and compact floc aggregates and some filamentous bacteria on the sponge, and spherical-, ovoid- and shortrod-shaped microorganisms on the volcanic rock and charcoal. Using porous material as carrier for biofilm development is an effective strategy for practical application of the anammox reactor.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Nitrogênio/metabolismo
Eliminação de Resíduos Líquidos/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Compostos de Amônio
Reatores Biológicos/microbiologia
Carvão Vegetal
Crescimento Quimioautotrófico
Desnitrificação
Nitrificação
Nitritos
Nitrogênio/análise
Oxirredução
Esgotos/microbiologia
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Nitrites); 0 (Sewage); 0 (Water Pollutants, Chemical); 16291-96-6 (Charcoal); N762921K75 (Nitrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1294624


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[PMID]:29465577
[Au] Autor:Peng T; Hu Z; Yang X; Gao Y; Ma C
[Ad] Endereço:Department of Nephrology, Shandong University Qilu Hospital, Jinan City, China.
[Ti] Título:Nitrite-induced acute kidney injury with secondary hyperparathyroidism: Case report and literature review.
[So] Source:Medicine (Baltimore);97(8):e9889, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Acute kidney injury (AKI) with hyperparathyroidism caused by nitrite was rare, and renal function and parathyroid hormone (PTH) decreased to normal range after therapy. PATIENT CONCERNS: Acute kidney injury was diagnosed in a 40-year-old male with hyperparathyroidism and cyanosis of his hands and both forearms. DIAGNOSES: The patient ate some recently pickled vegetables, and he experienced nausea, vomiting and diarrhoea without oliguria or anuria; Additionally, his hands and both forearms had a typical blue ash appearance. After admission, the laboratory findings indicated theincreasing serum creatinine (Scr) and parathyroid hormone (PTH). He was diagnosed as acute kidney injury with hyperparathyroidism caused by nitrite. INTERVENTIONS: The patient stopped eating the pickled vegetables and was given rehydration, added calories and other supportive therapy without any glucocorticoids. OUTCOMES: According to his clinical manifestations, laboratory findings and imaging results, the patient was diagnosed with acute kidney injury with secondary hyperparathyroidism. He was given symptomatic supportive care therapy. After one week, the serum creatinine, parathyroid hormone (PTH), hypercalcemia, hyperphosphatemia, proteinuria, and urine red blood cell values decreased to normal range. LESSONS: Nitrite-induced acute kidney injury with secondary hyperparathyroidism was relatively rare. After therapy, the function of the kidney and parathyroid returned to normal. This case suggests that detailed collection of medical history, physical examination and correct symptomatic treatment is very important.
[Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente
Hiperparatireoidismo Secundário/induzido quimicamente
Nitritos/envenenamento
[Mh] Termos MeSH secundário: Lesão Renal Aguda/terapia
Adulto
Cianose/induzido quimicamente
Diarreia/induzido quimicamente
Hidratação
Conservação de Alimentos
Seres Humanos
Hiperparatireoidismo Secundário/terapia
Masculino
Náusea/induzido quimicamente
Apoio Nutricional
Vômito/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Nitrites)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009889


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[PMID]:29199992
[Au] Autor:Oulavallickal T; Brewster JL; McKellar JLO; Fairhurst MJ; Tenci NA; Gerth ML
[Ad] Endereço:Department of Biochemistry, University of Otago, PO Box 56, Dunedin, Otago 9054, New Zealand.
[Ti] Título:The Pseudomonas syringae pv. actinidiae chemoreceptor protein F (PscF) periplasmic sensor domain: cloning, purification and X-ray crystallographic analysis.
[So] Source:Acta Crystallogr F Struct Biol Commun;73(Pt 12):701-705, 2017 Dec 01.
[Is] ISSN:2053-230X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrate- and nitrite-sensing (NIT) domains are found associated with a wide variety of bacterial receptors, including chemoreceptors. However, the structure of a chemoreceptor-associated NIT domain has not yet been characterized. Recently, a chemoreceptor named PscF was identified from the plant pathogen Pseudomonas syringae pv. actinidiae that is predicted to contain a periplasmic NIT domain. The PscF sensor domain (PscF-SD; residues 42-332) was cloned into an appropriate expression vector, recombinantly produced in Escherichia coli BL21-Gold(DE3) cells and purified via immobilized metal-affinity and size-exclusion chromatography. Purified PscF-SD was screened for crystallization; the best crystal diffracted to a maximum resolution of 1.46 Šin space group P2 2 2 . However, the data could not be phased using the only available NIT-domain structure (Klebsiella oxytoca NasR; PDB entry 4akk) as the search model. Therefore, a data set from a selenomethionine-labelled protein crystal was also collected. The selenomethionine-labelled protein crystal diffracted to a resolution of 2.46 Šin space group P2 2 2 . These data will be used to attempt to solve the structure using the single-wavelength anomalous diffraction technique. The structure is expected to provide insights into the ligand specificity of NIT domains and the role of NIT domains in chemotaxis.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Pseudomonas syringae/química
[Mh] Termos MeSH secundário: Proteínas de Bactérias/isolamento & purificação
Fatores Quimiotáticos
Cromatografia de Afinidade
Cromatografia em Gel
Clonagem Molecular
Cristalografia por Raios X
Nitratos/química
Nitratos/metabolismo
Nitritos/química
Nitritos/metabolismo
Periplasma/metabolismo
Domínios Proteicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Chemotactic Factors); 0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1107/S2053230X17016831


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[PMID]:28458145
[Au] Autor:Bischin C; Mot A; Stefancu A; Leopold N; Hathazi D; Damian G; Silaghi-Dumitrescu R
[Ad] Endereço:Department of Chemistry, Babes-Bolyai University, 11 Arany Janos Street, Cluj-Napoca 400028, Romania.
[Ti] Título:Chlorite reactivity with myoglobin: Analogy with peroxide and nitrite chemistry?
[So] Source:J Inorg Biochem;172:122-128, 2017 Jul.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stopped-flow UV-vis data allow for the first time direct spectroscopic detection of a ferryl species during the reaction of met myoglobin (Mb) with chlorite, analogous to what is observed in the reaction with peroxides. Ferryl is also observed in the reaction of oxy Mb+chlorite. A pathway involving Fe-O-O-ClO is explored by analogy with the Fe-O-O-NO and Fe-O-O-NO previously proposed as intermediates in the reactions of oxy globins with nitric oxide and nitrite, respectively. However, Fe-O-O-ClO is not detectable in these stopped-flow experiments and is in fact, unlike its nitrogenous congeners, predicted by density functional theory (DFT) to be impossible for a heme complex. Deoxy Mb reacts with chlorite faster than met - suggesting that, unlike with hydrogen peroxide (with which deoxy Mb reacts slower than met), binding of chlorite to the heme is not a rate-determining step (hence, most likely, an outer-sphere electron transfer mechanism); to correlate this, a Fe-O-Cl-O adduct was not observed experimentally for the met or for the deoxy reactions - even though prior DFT calculations suggest it to be feasible and detectable.
[Mh] Termos MeSH primário: Cloretos/química
Mioglobina/química
Nitritos/química
Peróxidos/química
Teoria Quântica
[Mh] Termos MeSH secundário: Heme/química
Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Myoglobin); 0 (Nitrites); 0 (Peroxides); 42VZT0U6YR (Heme); Z63H374SB6 (chlorite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  5 / 16282 MEDLINE  
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[PMID]:28456767
[Au] Autor:Almeida RT; Galdino G; Perez AC; Silva G; Romero TR; Duarte ID
[Ad] Endereço:Department of Pharmacology, Institute of Biological Sciences, Federal University of Belo Horizonte, Minas Gerais, Brazil. imitri@icb.ufmg.br.
[Ti] Título:St36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats.
[So] Source:J Physiol Pharmacol;68(1):27-33, 2017 Feb.
[Is] ISSN:1899-1505
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Orofacial pain is pain perceived in the face and/or oral cavity, generally caused by diseases or disorders of regional structures, by dysfunction of the nervous system, or through referral from distant sources. Treatment of orofacial pain is mainly pharmacological, but it has increased the number of reports demonstrating great clinical results with the use of non-pharmacological therapies, among them electroacupuncture. However, the mechanisms involved in the electroacupuncture are not well elucidated. Thus, the present study investigate the involvement of the nitric oxide synthase (NOS) and ATP sensitive K channels (KATP) in the antinociception induced by electroacupuncture (EA) at acupoint St36. Thermal nociception was applied in the vibrissae region of rats, and latency time for face withdrawal was measured. Electrical stimulation of acupoint St36 for 20 minutes reversed the thermal withdrawal latency and this effect was maintained for 150 min. Intraperitoneal administration of specific inhibitors of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and a KATP channels blocker reversed the antinociception induced by EA. Furthermore, nitrite concentration in cerebrospinal fluid (CSF) and plasma, increased 4 and 3-fold higher, respectively, after EA. This study suggests that NO participates of antinociception induced by EA by nNOS, iNOS and ATP-sensitive K channels activation.
[Mh] Termos MeSH primário: Pontos de Acupuntura
Eletroacupuntura
Dor Facial/terapia
Manejo da Dor
[Mh] Termos MeSH secundário: Animais
Dor Facial/fisiopatologia
Temperatura Alta/efeitos adversos
Canais KATP/antagonistas & inibidores
Canais KATP/fisiologia
Masculino
Óxido Nítrico Sintase Tipo I/antagonistas & inibidores
Óxido Nítrico Sintase Tipo I/fisiologia
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Óxido Nítrico Sintase Tipo II/fisiologia
Nitritos/sangue
Nitritos/líquido cefalorraquidiano
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KATP Channels); 0 (Nitrites); EC 1.14.13.39 (Nitric Oxide Synthase Type I); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, rat)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:27779565
[Au] Autor:Son WM; Sung KD; Cho JM; Park SY
[Ad] Endereço:1Department of Ocean Physical Education, National Korea Maritime and Ocean University, Busan, Korea 2Department of Physical Education, Pusan National University, Busan, Korea 3Department of Exercise and Sport Science, The University of Utah, Salt Lake City, UT 4Department of Cardiology, Boston University School of Medicine, Boston, MA.
[Ti] Título:Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension.
[So] Source:Menopause;24(3):262-268, 2017 Mar.
[Is] ISSN:1530-0374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Postmenopausal women exhibit elevated brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, which is associated with an increased risk of cardiovascular events and mortality. The purpose of this study is to examine the impact of combined resistance and aerobic exercise training on baPWV, blood pressure (BP), and cardiovascular fitness in postmenopausal women with stage 1 hypertension. METHODS: Twenty postmenopausal women (age, 75 ±â€Š2 y; systolic BP, 152 ±â€Š2 mm Hg, diastolic BP, 95 ±â€Š3 mm Hg) were randomly assigned to a "no-exercise" (CON, n = 10) or combined exercise (EX, n = 10) group. The EX group performed resistance and aerobic exercise for 12 weeks, 3 times per week. Exercise intensity was increased gradually, from 40% to 70% of heart rate reserve, every 4 weeks. BaPWV, BP, blood nitrite/nitrate, endothelin-1 (ET-1), cardiovascular fitness, and body composition were measured before and after the 12-week intervention. RESULTS: BP, baPWV (-1.2 ±â€Š0.4 m/s), ET-1 (-2.7 ±â€Š0.3 µmol/mL), nitrite/nitrate (+4.5 ±â€Š0.5 µM), functional capacity, and body composition were significantly improved (P < 0.05) in the EX group after 12 weeks of training, but no changes were observed in the CON group. CONCLUSIONS: These findings indicate that 12 weeks of combined exercise training improves arterial stiffness, BP, ET-1, blood nitrite/nitrate, functional capacity, and body composition in postmenopausal women with stage 1 hypertension. Thus, this study provides evidence that combined exercise training is a useful therapeutic method to improve cardiovascular health which can reduce cardiovascular disease risk in postmenopausal women with hypertension.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Hipertensão/terapia
Pós-Menopausa
Treinamento de Resistência/métodos
Rigidez Vascular/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Índice Tornozelo-Braço
Biomarcadores/sangue
Composição Corporal
Doenças Cardiovasculares/etiologia
Exercício/fisiologia
Feminino
Seres Humanos
Hipertensão/complicações
Hipertensão/fisiopatologia
Nitratos/sangue
Nitritos/sangue
Pós-Menopausa/sangue
Análise de Onda de Pulso
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1097/GME.0000000000000765


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[PMID]:28921575
[Au] Autor:Quist AJL; Inoue-Choi M; Weyer PJ; Anderson KE; Cantor KP; Krasner S; Freeman LEB; Ward MH; Jones RR
[Ad] Endereço:Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
[Ti] Título:Ingested nitrate and nitrite, disinfection by-products, and pancreatic cancer risk in postmenopausal women.
[So] Source:Int J Cancer;142(2):251-261, 2018 Jan 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986-2011). We used historical monitoring and treatment data to estimate levels of long-term average nitrate and total trihalomethanes (TTHM; the sum of the most prevalent DBP class) and the duration exceeding one-half the maximum contaminant level (>½ MCL; 5 mg/L nitrate-nitrogen, 40 µg/L TTHM) among participants on public water supplies (PWS) >10 years. We estimated dietary nitrate and nitrite intakes using a food frequency questionnaire. We computed hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression and evaluated nitrate interactions with smoking and vitamin C intake. We identified 313 cases among 34,242 women, including 152 with >10 years PWS use (N = 15,710). Multivariable models of average nitrate showed no association with pancreatic cancer (HR = 1.16, 95% CI: 0.51-2.64). Associations with average TTHM levels were also null (HR = 0.70, 95% CI:0.42-1.18). We observed no trend with increasing years of exposure to either contaminant at levels >½ MCL. Positive associations were suggested in the highest dietary nitrite intake from processed meat (HR = 1.66, 95% CI 1.00-2.75;p = 0.05). We found no interactions of nitrate with known modifiers of endogenous NOC formation. Our results suggest that nitrite intake from processed meat may be a risk factor for pancreatic cancer.
[Mh] Termos MeSH primário: Desinfecção/métodos
Nitratos/efeitos adversos
Nitritos/efeitos adversos
Neoplasias Pancreáticas/etiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seguimentos
Seres Humanos
Iowa
Meia-Idade
Estadiamento de Neoplasias
Pós-Menopausa
Prognóstico
Estudos Prospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.31055


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[PMID]:28917815
[Au] Autor:Wang J; Tang H; Zhang X; Xue X; Zhu X; Chen Y; Yang Z
[Ad] Endereço:Jiangsu Province Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China.
[Ti] Título:Mitigation of nitrite toxicity by increased salinity is associated with multiple physiological responses: A case study using an economically important model species, the juvenile obscure puffer (Takifugu obscurus).
[So] Source:Environ Pollut;232:137-145, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nitrite is a common pollutant in water and is highly toxic to aquatic animals. To reveal the mechanism of salinity in attenuating nitrite toxicity to fish, we measured the physiological responses of juvenile Takifugu obscurus exposed to nitrite concentrations (0, 10, 20, 50, and 100 mg/L) under different salinity levels (0, 10, and 20 ppt) for 96 h. Salinity increased the survival rates of juvenile T. obscurus exposed to nitrite. Changes in key hematological parameters, antioxidant system, malondialdehyde, Na /K -ATPase, and HSP70 indicated that nitrite induced considerable damage to juveniles; salinity mitigated the harmful effects. This finding reflects similar changing trends in both antioxidants and their gene expressions among different tissues. We applied an overall index, an integrated biomarker response (IBR), that increased under high-nitrite condition but recovered to the normal levels under salinity treatment. Analysis of the selected detection indices and IBR values showed that the overall mitigating effect of salinity on nitrite toxicity seems to be at sub-cellular level and associated with complicated physiological responses.
[Mh] Termos MeSH primário: Nitritos/toxicidade
Salinidade
Takifugu/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes
Peixes/metabolismo
Malondialdeído/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Nitrites); 0 (Water Pollutants, Chemical); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


  9 / 16282 MEDLINE  
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[PMID]:28470863
[Au] Autor:Ravikumar G; Bagheri M; Saini DK; Chakrapani H
[Ad] Endereço:Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, 411008, Maharashtra, India.
[Ti] Título:FLUORO/NO: A Nitric Oxide Donor with a Fluorescence Reporter.
[So] Source:Chembiochem;18(15):1529-1534, 2017 08 04.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Nitric oxide (NO) plays significant signalling roles in cells; the controlled generation of NO is of therapeutic relevance. Although a number of methods for the delivery and detection of NO are available, these events are typically mutually exclusive. Furthermore, the efficiency of delivery of NO can be compromised by detection technologies that consume NO. Here, we report FLUORO/NO, an esterase-activated diazeniumdiolate-based NO donor with an in-built fluorescence reporter. We demonstrate that this compound is capable of enhancing NO within cells in a dose-dependent manner, accompanied by a similar increase in fluorescence. The compatibility of this tool to study NO-mediated signalling as well as NO-mediated stress is demonstrated. FLUORO/NO is a convenient tool that shows NO-like activity and allows monitoring of NO release. This tool will help interrogate the redox biology of NO.
[Mh] Termos MeSH primário: Cumarínicos/farmacologia
Doadores de Óxido Nítrico/farmacologia
Triazenos/farmacologia
Triazinas/farmacologia
Umbeliferonas/farmacologia
[Mh] Termos MeSH secundário: Carboxilesterase/metabolismo
Cumarínicos/síntese química
Dano ao DNA
Fluorescência
Células HEK293
Células HeLa
Seres Humanos
Óxido Nítrico/metabolismo
Doadores de Óxido Nítrico/síntese química
Nitritos/análise
Guanilil Ciclase Solúvel/metabolismo
Estereoisomerismo
Triazenos/síntese química
Triazinas/síntese química
Umbeliferonas/síntese química
Valeratos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coumarins); 0 (FLUORO-NO compound); 0 (Nitric Oxide Donors); 0 (Nitrites); 0 (Triazenes); 0 (Triazines); 0 (Umbelliferones); 0 (Valerates); 31C4KY9ESH (Nitric Oxide); EC 3.1.1.1 (Carboxylesterase); EC 4.6.1.2 (Soluble Guanylyl Cyclase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700155


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[PMID]:29236285
[Au] Autor:Akimov OY; Kostenko VO
[Ti] Título:Functioning of nitric oxide cycle in gastric mucosa of rats under excessive combined intake of sodium nitrate and fluoride.
[So] Source:Ukr Biochem J;88(6):70-5, 2016 Nov-Dec.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:In the article the function of nitric oxide (·NO) cycle in rat's gastric mucosa was assessed under excessive combined chronic fluoride and nitrate intake during 30 days. It was estimated that general nitric oxide synthase activity (NOS) was increased during excessive sodium fluoride intake meanwhile influence on gene­ral nitrate reduction was not statistically significant, but general nitrite reduction was increased. General arginase activity decreased. Excessive sodium nitrate intake decreased NOS activity, but increased nitrate, nitrite reduction and general arginase activity. Combined sodium nitrate and fluoride intake increased NOS by 18.9%, nitrate reduction by 71.7%, nitrite by 161.5%, arginase activity increase by 61.4%. The highest amounts of peroxynitrite were obtained from excessive sodium fluoride intake group, excessive sodium nitrate intake showed the lowest levels and combined excessive sodium nitrate and fluoride intake levels had intermediate results. Summarizing the data obtained, the authors have made a conclusion that combined excessive sodium nitrate and fluoride intake creates optimal conditions for functioning of nitrate-nitrite reductases.
[Mh] Termos MeSH primário: Mucosa Gástrica/efeitos dos fármacos
Nitratos/administração & dosagem
Óxido Nítrico Sintase/genética
Óxido Nítrico/biossíntese
Fluoreto de Sódio/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Arginase/genética
Arginase/metabolismo
Feminino
Mucosa Gástrica/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Intubação Gastrointestinal
Masculino
Nitrato Redutase/genética
Nitrato Redutase/metabolismo
Nitratos/metabolismo
Óxido Nítrico Sintase/metabolismo
Nitritos/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrites); 31C4KY9ESH (Nitric Oxide); 8M4L3H2ZVZ (sodium nitrate); 8ZYQ1474W7 (Sodium Fluoride); EC 1.14.13.39 (Nitric Oxide Synthase); EC 1.7.99.4 (Nitrate Reductase); EC 3.5.3.1 (Arginase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.06.070



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