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[PMID]:29214538
[Au] Autor:Akbarzade S; Chamsaz M; Rounaghi GH; Ghorbani M
[Ad] Endereço:Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
[Ti] Título:Zero valent Fe-reduced graphene oxide quantum dots as a novel magnetic dispersive solid phase microextraction sorbent for extraction of organophosphorus pesticides in real water and fruit juice samples prior to analysis by gas chromatography-mass spectrometry.
[So] Source:Anal Bioanal Chem;410(2):429-439, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A selective and sensitive magnetic dispersive solid-phase microextraction (MDSPME) coupled with gas chromatography-mass spectrometry was developed for extraction and determination of organophosphorus pesticides (Sevin, Fenitrothion, Malathion, Parathion, and Diazinon) in fruit juice and real water samples. Zero valent Fe-reduced graphene oxide quantum dots (rGOQDs@ Fe) as a new and effective sorbent were prepared and applied for extraction of organophosphorus pesticides using MDSPME method. In order to study the performance of this new sorbent, the ability of rGOQDs@ Fe was compared with graphene oxide and magnetic graphene oxide nanocomposite by recovery experiments of the organophosphorus pesticides. Several affecting parameters in the microextraction procedure, including pH of donor phase, donor phase volume, stirring rate, extraction time, and desorption conditions such as the type and volume of solvents and desorption time were thoroughly investigated and optimized. Under the optimal conditions, the method showed a wide linear dynamic range with R-square between 0.9959 and 0.9991. The limit of detections, the intraday and interday relative standard deviations (n = 5) were less than 0.07 ngmL , 4.7, and 8.6%, respectively. The method was successfully applied for extraction and determination of organophosphorus pesticides in real water samples (well, river and tap water) and fruit juice samples (apple and grape juice). The obtained relative recoveries were in the range of 82.9%-113.2% with RSD percentages of less than 5.8% for all the real samples.
[Mh] Termos MeSH primário: Sucos de Frutas e Vegetais/análise
Grafite/química
Compostos Organofosforados/análise
Praguicidas/análise
Microextração em Fase Sólida/métodos
Poluentes Químicos da Água/análise
Água/análise
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Ferro/química
Limite de Detecção
Compostos Organofosforados/isolamento & purificação
Oxirredução
Óxidos/química
Praguicidas/isolamento & purificação
Pontos Quânticos/química
Poluentes Químicos da Água/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Organophosphorus Compounds); 0 (Oxides); 0 (Pesticides); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 7782-42-5 (Graphite); E1UOL152H7 (Iron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0732-9


  2 / 20866 MEDLINE  
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[PMID]:29175397
[Au] Autor:Dong G; Huang L; Wu X; Wang C; Liu Y; Liu G; Wang L; Liu X; Xia H
[Ad] Endereço:Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, China. Electronic address: 963722867@qq.com.
[Ti] Título:Effect and mechanism analysis of MnO on permeable reactive barrier (PRB) system for the removal of tetracycline.
[So] Source:Chemosphere;193:702-710, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Effect of manganese dioxide (MnO ) on tetracycline (TC) removal/degradation in zero-valent iron (ZVI) based permeable reactive barrier (PRB) system was investigated. To analyze the role of MnO , three different PRB columns packed with ZVI, ZVI and a layer of MnO , and MnO were set up to investigate the removal effect and reaction mechanism of ZVI coupling with MnO on TC removal, respectively. The results show that the removal efficiencies of three PRB columns are 65%, 85%, and 50%, respectively. MnO could accelerate the transformation of Fe into Fe and combine with Fe to degrade TC in different reaction sites in the ZVI-MnO PRB system. Hydroxyl radicals (·OH) were produced in this process, which contributed to about 58.3% for the TC degradation. The UV-Vis spectrum demonstrated that A ring of TC was the main reaction site for interaction with Fe and the BCD rings were crucial for interactions with MnO . On the basis of intermediates identified by LC-ESI-MS, the ring structure of TC was opened, and low-molecular-weight compounds were produced in ZVI-MnO PRB system.
[Mh] Termos MeSH primário: Ferro/química
Compostos de Manganês/farmacologia
Óxidos/farmacologia
Tetraciclina/isolamento & purificação
[Mh] Termos MeSH secundário: Sítios de Ligação
Cromatografia Líquida
Estrutura Molecular
Espectrometria de Massas em Tandem
Tetraciclina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); E1UOL152H7 (Iron); F8VB5M810T (Tetracycline); TF219GU161 (manganese dioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  3 / 20866 MEDLINE  
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[PMID]:28841526
[Au] Autor:Rostamian R; Behnejad H
[Ad] Endereço:Department of Physical Chemistry, School of Chemistry, University College of Science, University of Tehran, Tehran 14155, Iran.
[Ti] Título:A comprehensive adsorption study and modeling of antibiotics as a pharmaceutical waste by graphene oxide nanosheets.
[So] Source:Ecotoxicol Environ Saf;147:117-123, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The adsorption behavior of tetracycline (TCN), doxycycline (DCN) as the most common antibiotics in veterinary and ciprofloxacin (CPN) onto graphene oxide nanosheets (GOS) in aqueous solution was evaluated. The four factors influencing the adsorption of antibiotics (initial concentration, pH, temperature and contact time) were studied. The results showed that initial pH ∼ 6 to 7 and contact time ∼ 100 - 200min are optimum for each drug. The monolayer adsorption capacity was reduced with the increasing temperature from 25°C to 45°C. Non-linear regressions were carried out in order to define the best fit model for every system. To do this, eight error functions were applied to predict the optimum model. Among various models, Hill and Toth isotherm models represented the equilibrium adsorption data of antibiotics while the kinetic data were well fitted by pseudo second-order (PSO) kinetic model (DCN and TCN) and Elovich (CPN) models. The maximum adsorption capacity (q ) is found to be in the following order: CPN >> DCN > TCN, obtained from sips equation at the same temperature. The GOS shows highest adsorption capacity towards CPN up to 173.4mgg . The study showed that GOS can be removed more efficiently from water solution.
[Mh] Termos MeSH primário: Antibacterianos/análise
Grafite/química
Modelos Teóricos
Nanoestruturas/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Antibacterianos/química
Ciprofloxacino/análise
Ciprofloxacino/química
Doxiciclina/análise
Doxiciclina/química
Concentração de Íons de Hidrogênio
Cinética
Óxidos/química
Temperatura Ambiente
Tetraciclina/análise
Tetraciclina/química
Termodinâmica
Drogas Veterinárias/análise
Drogas Veterinárias/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oxides); 0 (Veterinary Drugs); 0 (Water Pollutants, Chemical); 5E8K9I0O4U (Ciprofloxacin); 7782-42-5 (Graphite); F8VB5M810T (Tetracycline); N12000U13O (Doxycycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  4 / 20866 MEDLINE  
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[PMID]:28946119
[Au] Autor:Wanag A; Rokicka P; Kusiak-Nejman E; Kapica-Kozar J; Wrobel RJ; Markowska-Szczupak A; Morawski AW
[Ad] Endereço:West Pomeranian University of Technology, Szczecin, Faculty of Chemical Technology and Engineering, Institute of Inorganic Technology and Environment Engineering, Pulaskiego 10, 70-322 Szczecin, Poland. Electronic address: awanag@zut.edu.pl.
[Ti] Título:Antibacterial properties of TiO modified with reduced graphene oxide.
[So] Source:Ecotoxicol Environ Saf;147:788-793, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper, the antibacterial activity of titanium dioxide modified with reduced graphene oxide (rGO) was presented. TiO /rGO photocatalysts were prepared by the hydrothermal method under elevated pressure at 180°C and heated at 100°C in Ar flow. The obtained photocatalysts were characterized by means of XRD, FTIR/DRS, UV-vis/DR, Raman spectroscopy and scanning electron microscopy (SEM). The carbon content was also examined. FTIR/DRS and Raman analysis confirmed the presence of rGO in the TiO structure, suggesting a successful modification. The antimicrobial photoactivity of photocatalysts was conducted against E. coli under an artificial solar light. The results show that all TiO /rGO photocatalysts exhibited an antibacterial activity higher than unmodified TiO . The best result was found for sample with 1.5wt% additive of reduced graphene oxide. In this case, total inactivation of E. coli was noticed after 75min of irradiation. It was found that the presence of rGO in sample improves the antimicrobial activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Desinfecção/métodos
Escherichia coli/efeitos dos fármacos
Grafite/química
Titânio/farmacologia
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Antibacterianos/química
Catálise
Escherichia coli/efeitos da radiação
Óxidos/química
Propriedades de Superfície
Titânio/química
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oxides); 15FIX9V2JP (titanium dioxide); 7782-42-5 (Graphite); D1JT611TNE (Titanium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


  5 / 20866 MEDLINE  
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[PMID]:28826031
[Au] Autor:Tran HN; Viet PV; Chao HP
[Ad] Endereço:Department of Environmental Engineering, Chung Yuan Christian University, Chungli 32023, Taiwan.
[Ti] Título:Surfactant modified zeolite as amphiphilic and dual-electronic adsorbent for removal of cationic and oxyanionic metal ions and organic compounds.
[So] Source:Ecotoxicol Environ Saf;147:55-63, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A hydrophilic Y zeolite was primarily treated with sodium hydroxide to enhance its cation exchange capacity (Na-zeolite). The organo-zeolite (Na-H-zeolite) was prepared by a modification process of the external surface of Na-zeolite with a cationic surfactant (hexadecyltrimethylammonium; HDTMA). Three adsorbents (i.e., pristine zeolite, Na-zeolite, and Na-H-zeolite) were characterized with nitrogen adsorption/desorption isotherms, scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, cation exchange capacities, and zeta potential. Results demonstrated that HDTMA can be adsorbed on the surface of Na-zeolite to form patchy bilayers. The adsorption capacity of several hazardous pollutants (i.e., Pb , Cu , Ni , Cr O , propylbenzene, ethylbenzene, toluene, benzene, and phenol) onto Na-H-zeolite was investigated in a single system and multiple-components. Adsorption isotherm was measured to further understand the effects of the modification process on the adsorption behaviors of Na-H-zeolite. Adsorption performances indicated that Na-H-zeolite can simultaneously adsorb the metal cations (on the surface not covered by HDTMA), oxyanions (on the surface covered by HDTMA). Na-H-zeolite also exhibited both hydrophilic and hydrophobic surfaces to uptake organic compounds with various water solubilities (from 55 to 75,000mg/L). It was experimentally concluded that Na-H-zeolite is a potential dual-electronic and amphiphilic adsorbent for efficiently removing a wide range of potentially toxic pollutants from aquatic environments.
[Mh] Termos MeSH primário: Metais Pesados/análise
Compostos Orgânicos/análise
Tensoativos/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
Zeolitas/química
[Mh] Termos MeSH secundário: Adsorção
Ânions
Cátions
Interações Hidrofóbicas e Hidrofílicas
Metais Pesados/química
Modelos Teóricos
Compostos Orgânicos/química
Óxidos
Solubilidade
Propriedades de Superfície
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Cations); 0 (Metals, Heavy); 0 (Organic Chemicals); 0 (Oxides); 0 (Surface-Active Agents); 0 (Water Pollutants, Chemical); 1318-02-1 (Zeolites)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  6 / 20866 MEDLINE  
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[PMID]:28826028
[Au] Autor:Soleimani K; Tehrani AD; Adeli M
[Ad] Endereço:Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, Iran.
[Ti] Título:Bioconjugated graphene oxide hydrogel as an effective adsorbent for cationic dyes removal.
[So] Source:Ecotoxicol Environ Saf;147:34-42, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, graphene oxide - cellulose nanowhiskers nanocomposite hydrogel was easily synthesized through covalent functionalization of cellulose nanowhiskers with graphene oxide via a facile approach. The nitrene chemistry applied for covalent functionalization of graphene oxide sheets. The surface morphology and chemical structure of the nanocomposite hydrogel were characterized by FTIR, TGA, Raman, XRD, elemental analysis and SEM. The UV/Visible absorption spectrum revealed that the obtained porous nanocomposite hydrogel can efficiently remove cationic dyes such as methylene blue (MB) and Rhodamine B (RhB) from wastewater with high absorption power. The adsorption process showed that 100% of MB and 90% of RhB have been removed and the equilibrium state has been reached in 15min for low concentration solutions in accordance with the pseudo-second-order model. Moreover, the sample exhibited stable performance after being used several times. High adsorption capacity and easy recovery are the efficient factors making these materials as good adsorbent for water pollutants and wastewater treatment.
[Mh] Termos MeSH primário: Corantes/análise
Grafite/química
Hidrogel de Polietilenoglicol-Dimetacrilato/química
Nanocompostos/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Cátions
Corantes/química
Óxidos/química
Águas Residuais/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Coloring Agents); 0 (Oxides); 0 (Waste Water); 0 (Water Pollutants, Chemical); 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 7782-42-5 (Graphite)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  7 / 20866 MEDLINE  
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[PMID]:29200844
[Au] Autor:Al-Hada NM; Mohamed Kamari H; Abdullah CAC; Saion E; Shaari AH; Talib ZA; Matori KA
[Ad] Endereço:Department of Physics, Faculty of Science.
[Ti] Título:Down-top nanofabrication of binary (CdO) (ZnO) nanoparticles and their antibacterial activity.
[So] Source:Int J Nanomedicine;12:8309-8323, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:In the present study, binary oxide (cadmium oxide [CdO]) (zinc oxide [ZnO]) nanoparticles (NPs) at different concentrations of precursor in calcination temperature were prepared using thermal treatment technique. Cadmium and zinc nitrates (source of cadmium and zinc) with polyvinylpyrrolidone (capping agent) have been used to prepare (CdO) (ZnO) NPs samples. The sample was characterized by X-ray diffraction (XRD), scanning electron microscopy, energy-dispersive X-ray (EDX), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. XRD patterns analysis revealed that NPs were formed after calcination, which showed a cubic and hexagonal crystalline structure of (CdO) (ZnO) NPs. The phase analysis using EDX spectroscopy and FTIR spectroscopy confirmed the presence of Cd and Zn as the original compounds of prepared (CdO) (ZnO) NP samples. The average particle size of the samples increased from 14 to 33 nm as the concentration of precursor increased from x=0.20 to x=0.80, as observed by TEM results. The surface composition and valance state of the prepared product NPs were determined by X-ray photoelectron spectroscopy (XPS) analyses. Diffuse UV-visible reflectance spectra were used to determine the optical band gap through the Kubelka-Munk equation; the energy band gap was found to decrease for CdO from 2.92 to 2.82 eV and for ZnO from 3.22 to 3.11 eV with increasing x value. Additionally, photoluminescence (PL) spectra revealed that the intensity in PL increased with an increase in particle size. In addition, the antibacterial activity of binary oxide NP was carried out in vitro against ATCC 25922 Gram (-ve), ATCC 10708, and UPMC 1175 Gram (+ve). This study indicated that the zone of inhibition of 21 mm has good antibacterial activity toward the Gram-positive UPMC 1175.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Compostos de Cádmio/química
Nanopartículas/química
Óxidos/química
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Bacillus subtilis/efeitos dos fármacos
Compostos de Cádmio/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Óxidos/farmacologia
Tamanho da Partícula
Espectroscopia Fotoeletrônica
Salmonella/efeitos dos fármacos
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
Óxido de Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cadmium Compounds); 0 (Oxides); 0H3KWS8KJ3 (cadmium oxide); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S150405


  8 / 20866 MEDLINE  
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[PMID]:29184404
[Au] Autor:Jeong JK; Lee YJ; Jeong SY; Jeong S; Lee GW; Park SY
[Ad] Endereço:Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Iksan.
[Ti] Título:Autophagic flux induced by graphene oxide has a neuroprotective effect against human prion protein fragments.
[So] Source:Int J Nanomedicine;12:8143-8158, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Graphene oxide (GO) is a nanomaterial with newly developing biological applications. Autophagy is an intracellular degradation system that has been associated with the progression of neurodegenerative disorders. Although induction of autophagic flux by GO has been reported, the underlying signaling pathway in neurodegenerative disorders and how this is involved in neuroprotection remain obscure. We show that GO itself activates autophagic flux in neuronal cells and confers a neuroprotective effect against prion protein (PrP) (106-126)-mediated neurotoxicity. GO can be detected in SK-N-SH neuronal cells, where it triggers autophagic flux signaling. GO-induced autophagic flux prevented PrP (106-126)-induced neurotoxicity in SK-N-SH cells. Moreover, inactivation of autophagic flux blocked GO-induced neuroprotection against prion-mediated mitochondrial neurotoxicity. This is the first study to demonstrate that GO regulates autophagic flux in neuronal cells, and that activation of autophagic flux signals, induced by GO, plays a neuroprotective role against prion-mediated mitochondrial neurotoxicity. These results suggest that the nanomaterial GO may be used to activate autophagic flux and could be used in neuroprotective strategies for treatment of neurodegenerative disorders, including prion diseases.
[Mh] Termos MeSH primário: Autofagia/efeitos dos fármacos
Grafite/farmacologia
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Fragmentos de Peptídeos/toxicidade
Príons/toxicidade
[Mh] Termos MeSH secundário: Linhagem Celular
Grafite/química
Seres Humanos
Mitocôndrias/metabolismo
Neurônios/patologia
Fármacos Neuroprotetores/química
Óxidos/química
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (Oxides); 0 (Peptide Fragments); 0 (Prions); 0 (prion protein (106-126)); 7782-42-5 (Graphite)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S146398


  9 / 20866 MEDLINE  
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[PMID]:29465554
[Au] Autor:Collinge E; Tigaud I; Balme B; Gerland LM; Sujobert P; Carlioz V; Salles G; Thomas X; Paubelle E
[Ad] Endereço:Department of Hematology, CHU UCL Namur, Belgium.
[Ti] Título:Case report: Purulent transformation of granulocytic sarcoma: An unusual pattern of differentiation in acute promyelocytic leukemia.
[So] Source:Medicine (Baltimore);97(8):e9657, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. APL is currently treated with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) resulting in the induction of apoptosis and differentiation of the leukemic cells. Differentiation syndrome (so-called ATRA syndrome) is the main life-threatening complication of induction therapy with these differentiating agents. PATIENT CONCERNS: Herein, we report the case of a 49-year-old woman diagnosed with APL with, concomitantly, a bulky cutaneous lesion of 10 cm diameter with a red-to-purple background and a necrotic center, localized on her abdomen. DIAGNOSES: After 10 days of treatment, the cutaneous lesion became purulent. Fluorescence in situ hybridization (FISH) analysis performed on this pus confirmed the presence of malignant features in the involved granulocytes proving their origin from the differentiation of leukemic APL cells, as all the analyzed nuclei showed 2 promyelocytic leukemia (PML)-retinoic acid receptor-a (RARA) fusions signals. INTERVENTION: The association by ATRA and ATO was continued. OUTCOME: Eventually, the evolution was favorable with healing in three weeks. LESSONS: This case report therefore highlights the differentiation phenomenon of promyelocytic blasts within promyelocytic sarcoma with the ATRA-ATO combination and the efficacy of this drug association in resolving both the malignant sarcoma and a secondary local infection.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Arsenicais/efeitos adversos
Leucemia Promielocítica Aguda/tratamento farmacológico
Óxidos/efeitos adversos
Sarcoma Mieloide/tratamento farmacológico
Tretinoína/efeitos adversos
[Mh] Termos MeSH secundário: Abdome/patologia
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Arsenicais/administração & dosagem
Diferenciação Celular/efeitos dos fármacos
Feminino
Seres Humanos
Quimioterapia de Indução/efeitos adversos
Meia-Idade
Óxidos/administração & dosagem
Sarcoma Mieloide/induzido quimicamente
Sarcoma Mieloide/patologia
Supuração/induzido quimicamente
Tretinoína/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Oxides); 5688UTC01R (Tretinoin); S7V92P67HO (arsenic trioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009657


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[PMID]:28460583
[Au] Autor:Nielsen BS; Larsen EH; Ladefoged O; Lam HR
[Ad] Endereço:1 Environment and Toxicology, DHI, Hørsholm, Denmark.
[Ti] Título:Subchronic, Low-Level Intraperitoneal Injections of Manganese (IV) Oxide and Manganese (II) Chloride Affect Rat Brain Neurochemistry.
[So] Source:Int J Toxicol;36(3):239-251, 2017 May/Jun.
[Is] ISSN:1092-874X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0.9% NaCl (control), 1.22 mg Mn (as MnO )/kg bodyweight (bw)/day, or 2.5 mg Mn (as MnCl )/kg bw/day for 7 d/wk for 8 or 12 weeks. This dosing regimen adds relevant new knowledge about Mn neurotoxicity as a consequence of low-dose subchronic Mn dosing. Manganese concentrations increased in the striatum, the rest of the brain, and in plasma, and regional brain neurotransmitter concentrations, including noradrenaline, dopamine (DA), 5-hydroxytrytamine, glutamate, taurine, and γ-amino butyric acid, and the activity of acetylcholinesterase changed. Importantly, a target parameter for Parkinson disease and manganism, the striatal DA concentration, was reduced after 12 weeks of dosing with MnCl . Plasma prolactin concentration was not significantly affected due to a potentially reduced dopaminergic inhibition of the prolactin release from the anterior hypophysis. No effects on the striatal α-synuclein and synaptophysin protein levels were detected.
[Mh] Termos MeSH primário: Química Encefálica/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Cloretos/toxicidade
Óxidos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Encéfalo/metabolismo
Cloretos/sangue
Cloretos/farmacocinética
Dopamina/metabolismo
Ácido Glutâmico/metabolismo
Injeções Intraperitoneais
Masculino
Manganês/sangue
Manganês/metabolismo
Compostos de Manganês/sangue
Compostos de Manganês/farmacocinética
Norepinefrina/metabolismo
Óxidos/sangue
Óxidos/farmacocinética
Ratos Sprague-Dawley
Serotonina/metabolismo
Taurina/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Manganese Compounds); 0 (Oxides); 1EQV5MLY3D (Taurine); 333DO1RDJY (Serotonin); 3KX376GY7L (Glutamic Acid); 42Z2K6ZL8P (Manganese); 56-12-2 (gamma-Aminobutyric Acid); 64J2OA7MH3 (manganese oxide); EC 3.1.1.7 (Acetylcholinesterase); QQE170PANO (manganese chloride); VTD58H1Z2X (Dopamine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1177/1091581817704378



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