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[PMID]:28942275
[Au] Autor:Yadav P; Kaur R; Kanwar MK; Sharma A; Verma V; Sirhindi G; Bhardwaj R
[Ad] Endereço:Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
[Ti] Título:Castasterone confers copper stress tolerance by regulating antioxidant enzyme responses, antioxidants, and amino acid balance in B. juncea seedlings.
[So] Source:Ecotoxicol Environ Saf;147:725-734, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to explore the effect of exogenous application of castasterone (CS) on physiologic and biochemical responses in Brassica juncea seedlings under copper (Cu) stress. Seeds were pre-soaked in different concentrations of CS and grown for 7 days under various levels of Cu. The exposure of B. juncea to higher levels of Cu led to decrease of morphologic parameters, with partial recovery of length and fresh weight in the CS pre-treated seedlings. Metal content was high in both roots and shoots under Cu exposure while the CS pre-treatment reduced the metal uptake. Accumulation of hydrogen peroxide (H O ) and superoxide anion radical (O ) were chosen as stress biomarker and higher levels of H O (88.89%) and O (62.11%) showed the oxidative stress in metal treated B. juncea seedlings, however, CS pre-treatment reduced ROS accumulation in Cu-exposed seedlings. The Cu exposures lead to enhance the plant's enzymatic and non-enzymatic antioxidant system. It was observed that enzymatic activities of ascorbate peroxidase (APOX), dehydroascorbate reductase (DHAR), and glutathione reductase (GR), glutathione perxoidase (GPOX) and gultrathione-s-transferase increased while activity of monodehydroascorbate reductase (MDHAR) decreased under Cu stress. The pre-treatment with CS positively affected the activities of enzymes. RT-PCR analysis showed that mRNA transcript levels were correlated with total enzymatic activity of DHAR, GR, GST and GSH. Increase in the gene expression of DHAR (1.85 folds), GR (3.24 folds), GST-1 (2.00 folds) and GSH-S (3.18 folds) was noticed with CS pre-treatment. Overall, the present study shows that Cu exposure induced severe oxidative stress in B. juncea plants and exogenous application of CS improved antioxidative defense system by modulating the ascorbate-glutathione cycle and amino acid metabolism.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Colestanóis/farmacologia
Cobre/toxicidade
Mostardeira/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Aminoácidos/metabolismo
Cobre/metabolismo
Relação Dose-Resposta a Droga
Expressão Gênica/efeitos dos fármacos
Peróxido de Hidrogênio/metabolismo
Mostardeira/enzimologia
Mostardeira/genética
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Antioxidants); 0 (Cholestanols); 0 (Soil Pollutants); 789U1901C5 (Copper); 80736-41-0 (castasterone); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:29441966
[Au] Autor:Zhao H; Meng W; Li Y; Liu W; Fu B; Yang Y; Zhang Q; Chen G
[Ti] Título:The protective effects of CHIR99021 against oxidative injury in LO2 cells.
[So] Source:Pharmazie;71(11):629-635, 2016 11 02.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hepatic ischemia-reperfusion injury is one of the most important factors for the prognosis of liver transplantation and hepatic surgery. It was reported that glycogen synthase kinase-3 (GSK-3) regulated injury response during ischemia-reperfusion. In this study, we investigated the protective effects of the GSK-3 inhibitor CHIR99021 against hepatic ischemia-reperfusion injury. A H2O2-induced oxidative injury model using LO2 cells was established. LO2 cells were divided into four groups, including blank control group, CHIR99021 control group treated with CHIR99021 alone, H2O2-injury group treated with H2O2 and protection group treated with H2O2 plus CHIR99021. Cell viability, cell apoptosis or necrosis was determined. Meanwhile, mitochondrial membrane potential, lipid peroxidation, cellular ROS levels, SOD activity, and serum contents of ALS and AST were measured. Protein and mRNA expressions were also detected. The results showed that a cell oxidative injury model was established by treating LO2 cells with 200 µmol/L H2O2 for 6 h. Cells exposed to H2O2 resulted in a significant decrease of cell viability and increase of cell apoptosis, which was accompanied by increasing ROS levels, disruption of mitochondrial membrane potential, excessive lipid peroxidation, reduction of SOD activity, and increased levels of ALT and AST. Treatment with CHIR99021 significantly protected LO2 cells against H2O2-induce oxidative injury by inhibiting the changes of above oxidative injury related indicators. Moreover, CHIR99021 treatment significantly reversed H2O2-induced decrease in p-GSK-3ßSer9 , Bcl-2, Bcl-xl, survivin and ß-catenin expression, whereas it significantly attenuated H2O2-induced increase in caspase-3, cleaved caspase-3 and p-JNK protein expression. In conclusion, CHIR99021 protected LO2 cells against H2O2-induced oxidative injury through reducing GSK-3ß activity and apoptosis, with underlying mechanisms involved in stabilizing mitochondrial membrane potential, attenuating cellular ROS generation, suppressing mitochondria-mediated apoptotic pathway, and activation of GSK-3ß/ß-catenin signaling pathway.
[Mh] Termos MeSH primário: Citoproteção/efeitos dos fármacos
Hepatócitos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Piridinas/farmacologia
Pirimidinas/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Apoptose/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Doença Hepática Induzida por Substâncias e Drogas/enzimologia
Doença Hepática Induzida por Substâncias e Drogas/patologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Quinase 3 da Glicogênio Sintase/biossíntese
Quinase 3 da Glicogênio Sintase/genética
Seres Humanos
Peróxido de Hidrogênio/farmacologia
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Necrose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Chir 99021); 0 (Pyridines); 0 (Pyrimidines); BBX060AN9V (Hydrogen Peroxide); EC 2.7.11.26 (Glycogen Synthase Kinase 3)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6714


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[PMID]:28278779
[Au] Autor:Lominchar MA; Rodríguez S; Lorenzo D; Santos N; Romero A; Santos A
[Ad] Endereço:a Dpto. Ingeniería Química, Facultad CC, Químicas , Universidad Complutense de Madrid , Madrid , Spain.
[Ti] Título:Phenol abatement using persulfate activated by nZVI, H O and NaOH and development of a kinetic model for alkaline activation.
[So] Source:Environ Technol;39(1):35-43, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three persulfate (PS) activation methods (nanoparticles of zero-valent iron (nZVI), hydrogen peroxide and alkali) were compared using phenol as target pollutant. Firstly, four experiments were conducted at 25°C in a batch way using the same initial phenol and oxidant concentrations (10 mM and 420 mM, respectively), being the molar ratio activator/PS fixed to 0.005 with nZVI (mass ratio 0.0011 nZVI/PS), to 2 using hydrogen peroxide and to 2 and 4 with NaOH. Phenol and PS conversions and aromatic byproducts profiles during 168 h reaction time were measured and compared, as well as mineralization and ecotoxicity of the samples. It was found that both phenol and aromatic byproducts (catechol and hydroquinone) totally disappeared using PS activated by alkali before 24 h, while a significant amount of aromatic intermediates was obtained with nZVI and H O . Additional runs were carried out using shorter times (0-2 h) to discriminate the oxidation route and the kinetic model of phenol abatement by using PS activated by alkali. Different initial concentrations of phenol (5-15 mM), PS (210 and 420 mM) and molar ratio NaOH/PS (2 and 4) were employed. The kinetic model obtained predicts accurately the evolution of phenol, persulfate, hydroquinone and catechol.
[Mh] Termos MeSH primário: Modelos Químicos
Nanopartículas/química
Fenol/química
Hidróxido de Sódio/química
Sulfatos/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Peróxido de Hidrogênio
Ferro
Cinética
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfates); 0 (Water Pollutants, Chemical); 339NCG44TV (Phenol); 55X04QC32I (Sodium Hydroxide); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1294203


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[PMID]:29478663
[Au] Autor:Zhang Q; Liu J; He Y; Yang J; Gao J; Liu H; Tang W; Chen Y; Fan W; Chen X; Chai F; Hatakeyama S
[Ad] Endereço:College of Environmental & Resource Sciences of Zhejiang University, Hangzhou 310058, China.
[Ti] Título:Measurement of hydrogen peroxide and organic hydroperoxide concentrations during autumn in Beijing, China.
[So] Source:J Environ Sci (China);64:72-81, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gaseous peroxides play important roles in atmospheric chemistry. To understand the pathways of the formation and removal of peroxides, atmospheric peroxide concentrations and their controlling factors were measured from 7:00 to 20:00 in September, October, and November 2013 at a heavily trafficked residential site in Beijing, China, with average concentrations of hydrogen peroxide (H O ) and methyl hydroperoxide (MHP) at 0.55ppb and 0.063ppb, respectively. H O concentrations were higher in the afternoon and lower in the morning and evening, while MHP concentrations did not exhibit a regular diurnal pattern. Both H O and MHP concentrations increased at dusk in most cases. Both peroxides displayed monthly variations with higher concentrations in September. These results suggested that photochemical activity was the main controlling factor on variations of H O concentrations during the measurement period. Increasing concentrations of volatile organic compounds emitted by motor vehicles were important contributors to H O and MHP enrichment. High levels of H O and MHP concentrations which occurred during the measurement period probably resulted from the transport of a polluted air mass with high water vapor content passing over the Bohai Bay, China.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Monitoramento Ambiental
Peróxidos/análise
[Mh] Termos MeSH secundário: Poluição do Ar
Atmosfera/química
Pequim
Peróxido de Hidrogênio/química
Estações do Ano
Compostos Orgânicos Voláteis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Peroxides); 0 (Volatile Organic Compounds); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


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[PMID]:28610437
[Au] Autor:Song Y; Zhou J; Wang X; Xie X; Zhao Y; Ni F; Huang W; Wang Z; Xiao W
[Ad] Endereço:a Jiangsu Kanion Pharmaceutical Co., Ltd. , Lianyungang , People's Republic of China.
[Ti] Título:A new ferulic acid ester from Rhodiola wallichiana var. cholaensis (Crassulaceae).
[So] Source:Nat Prod Res;32(1):77-84, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound 3 was isolated from this plant for the first time. The protective effects against H O -induced myocardial cell injury in cultured H9c2 cells were also evaluated. Compounds 1, 5 and 7-11 provided significant protective effects on H O -induced H9c2 cells injury at the concentration of 25 µg/mL. And the protective effects of compound 1 was also investigated by the oxygen-glucose deprivation/reperfusion (OGD/R) tests.
[Mh] Termos MeSH primário: Caproatos/farmacologia
Cardiotônicos/farmacologia
Ácidos Cumáricos/farmacologia
Rhodiola/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/farmacologia
Caproatos/administração & dosagem
Caproatos/química
Cardiotônicos/administração & dosagem
Cardiotônicos/química
Células Cultivadas
Ácidos Cumáricos/administração & dosagem
Ácidos Cumáricos/química
Relação Dose-Resposta a Droga
Ésteres/administração & dosagem
Ésteres/química
Ésteres/farmacologia
Peróxido de Hidrogênio/toxicidade
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Miócitos Cardíacos/citologia
Miócitos Cardíacos/efeitos dos fármacos
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Caproates); 0 (Cardiotonic Agents); 0 (Coumaric Acids); 0 (Esters); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335724


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[PMID]:29268102
[Au] Autor:Burgos-Castillo RC; Sirés I; Sillanpää M; Brillas E
[Ad] Endereço:Laboratory of Green Chemistry, School of Engineering Science, Lappeenranta University of Technology, Sammonkatu 12, FI-50130 Mikkeli, Finland. Electronic address: rutely.burgos.castillo@lut.fi.
[Ti] Título:Application of electrochemical advanced oxidation to bisphenol A degradation in water. Effect of sulfate and chloride ions.
[So] Source:Chemosphere;194:812-820, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrochemical oxidation with electrogenerated H O (EO- H O ), electro-Fenton (EF), photoelectro-Fenton (PEF) and solar PEF (SPEF) have been applied to mineralize bisphenol A solutions in 0.050 M Na SO or 0.008 M NaCl + 0.047 M Na SO at pH 3.0. The assays were performed in an undivided cell with a boron-doped diamond (BDD) anode and an air-diffusion cathode for continuous H O production. The PEF and SPEF processes yielded almost total mineralization due to the potent synergistic action of generated hydroxyl radicals and active chlorine, in conjunction with the photolytic action of UV radiation. The higher intensity of UV rays from sunlight explained the superior oxidation ability of SPEF. The effect of applied current density was studied in all treatments, whereas the role of bisphenol A concentration was examined in PEF. Bisphenol A abatement followed a pseudo-first-order kinetics, which was very quick in SPEF since UV light favored a large production of hydroxyl radicals from Fenton's reaction. Eight non-chlorinated and six chlorinated aromatics were identified as primary products in the chloride matrix. Ketomalonic, tartronic, maleic and oxalic acids were detected as final short-chain aliphatic carboxylic acids. The large stability of Fe(III)-oxalate complexes in EF compared to their fast photomineralization in PEF and PEF accounted for by the superior oxidation power of the latter processes.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/química
Cloretos/farmacologia
Técnicas Eletroquímicas/métodos
Fenóis/química
Fotólise
Sulfatos/farmacologia
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Peróxido de Hidrogênio/química
Radical Hidroxila/química
Ferro/química
Oxirredução
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Chlorides); 0 (Phenols); 0 (Sulfates); 0 (Water Pollutants, Chemical); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29442002
[Au] Autor:Vrbovská H; Babincová M
[Ti] Título:Comparative analysis of synthetic and nutraceutical antioxidants as possible neuroprotective agents.
[So] Source:Pharmazie;71(12):724-726, 2016 12 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Damage caused by oxidative stress in cases of neurodegenerative diseases such as Alzheimer's or Parkinson's has been proven to be irreversible. However, diet supplementation of antioxidants can be beneficial to the total antioxidant status of the human body. Given that oxidative stress is a principal cause of neurodegenerative disease, effective natural antioxidants could provide therapeutic options for these disorders. Therefore we investigated the antioxidant properties of two natural extracts and five synthetic compounds in lipid rich environment of liposomes with oxidation induced by Fenton's reagent. Antioxidant activity has been quantified using the Klein peroxidation index and oxygen uptake. Both natural extracts from Acai berry and Ginseng as well as all synthetic compounds - N-acetyl-L-cysteine, tocopherol, huperzines, caffeic acid and lipoic acid displayed good antioxidants properties, which confirm their suitability as neuroprotective agents.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Suplementos Nutricionais
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Euterpe/química
Peróxido de Hidrogênio
Ferro
Peroxidação de Lipídeos/efeitos dos fármacos
Lipídeos/química
Lipossomos
Estresse Oxidativo/efeitos dos fármacos
Consumo de Oxigênio
Panax/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fenton's reagent); 0 (Lipids); 0 (Liposomes); 0 (Neuroprotective Agents); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6730


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[PMID]:29343728
[Au] Autor:Carroll B; Otten EG; Manni D; Stefanatos R; Menzies FM; Smith GR; Jurk D; Kenneth N; Wilkinson S; Passos JF; Attems J; Veal EA; Teyssou E; Seilhean D; Millecamps S; Eskelinen EL; Bronowska AK; Rubinsztein DC; Sanz A; Korolchuk VI
[Ad] Endereço:Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University Institute for Ageing (NUIA), Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.
[Ti] Título:Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.
[So] Source:Nat Commun;9(1):256, 2018 01 17.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, it remains poorly understood how these mechanisms further evolved in higher organisms. Here we describe a modification in the autophagy pathway in vertebrates, which promotes its activity in response to oxidative stress. We have identified two oxidation-sensitive cysteine residues in a prototypic autophagy receptor SQSTM1/p62, which allow activation of pro-survival autophagy in stress conditions. The Drosophila p62 homologue, Ref(2)P, lacks these oxidation-sensitive cysteine residues and their introduction into the protein increases protein turnover and stress resistance of flies, whereas perturbation of p62 oxidation in humans may result in age-related pathology. We propose that the redox-sensitivity of p62 may have evolved in vertebrates as a mechanism that allows activation of autophagy in response to oxidative stress to maintain cellular homoeostasis and increase cell survival.
[Mh] Termos MeSH primário: Autofagia
Proteostase
Espécies Reativas de Oxigênio/metabolismo
Proteína Sequestossoma-1/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Drosophila melanogaster/citologia
Drosophila melanogaster/genética
Drosophila melanogaster/metabolismo
Células HEK293
Células HeLa
Seres Humanos
Peróxido de Hidrogênio/farmacologia
Camundongos Knockout
Oxidantes/farmacologia
Oxirredução
Homologia de Sequência de Aminoácidos
Proteína Sequestossoma-1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oxidants); 0 (Reactive Oxygen Species); 0 (Sequestosome-1 Protein); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02746-z


  9 / 49864 MEDLINE  
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[PMID]:29324335
[Au] Autor:Loubidi M; Jouha J; Tber Z; Khouili M; Suzenet F; Akssira M; Erdogan MA; Köse FA; Dagci T; Armagan G; Saso L; Guillaumet G
[Ad] Endereço:Institut de Chimie Organique et Analytique, Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067, Orléans Cedex 2, France; Equipe de Chimie Bioorganique & Analytique, URAC 22 Université Hassan II Mohammedia-Casablanca, BP 146, 28800, Mohammedia, Morocco.
[Ti] Título:Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H O -induced oxidative stress.
[So] Source:Eur J Med Chem;145:113-123, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Oxidative stress and apoptosis are both associated with various acute and chronic disorders. Thus, the aim of the present study is to synthesize imidazo[2,1-c][1,2,4]triazines derivatives and to evaluate their effects in H O -induced oxidative stress in human neuroblastoma cell line (SH-SY5Y cells). The effects of the compounds on cell viability were measured by MTT assay and the changes in stress and apoptosis-related proteins were investigated by PathScan Stress and Apoptosis Signaling Antibody Array kit and Western Blot technique. In particular, four compounds were found to protect SH-SY5Y cells from H O -induced toxicity by increasing Bcl-2/Bax ratio, regulating PI3-K/Akt cascade and inhibiting the ERK pathway.
[Mh] Termos MeSH primário: Peróxido de Hidrogênio/antagonistas & inibidores
Imidazóis/farmacologia
Triazinas/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Seres Humanos
Peróxido de Hidrogênio/farmacologia
Imidazóis/síntese química
Imidazóis/química
Estrutura Molecular
Estresse Oxidativo/efeitos dos fármacos
Estereoisomerismo
Relação Estrutura-Atividade
Triazinas/síntese química
Triazinas/química
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Imidazoles); 0 (Triazines); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


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[PMID]:29355013
[Au] Autor:Zhang W; Li X; Hua F; Chen W; Wang W; Chu GX; Bao GH
[Ad] Endereço:Natural Products Laboratory, International Joint Lab of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University , Hefei, 230036 People's Republic of China.
[Ti] Título:Interaction between Ester-Type Tea Catechins and Neutrophil Gelatinase-Associated Lipocalin: Inhibitory Mechanism.
[So] Source:J Agric Food Chem;66(5):1147-1156, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tea is thought to alleviate neurotoxicity due to the antioxidative effect of ester-type tea catechins (ETC). Neutrophil gelatinase-associated lipocalin (NGAL) can sensitize ß-amyloid (Aß) induced neurotoxicity, and inhibitors of NGAL may relieve associated symptoms. As such, the interactions of ETC with NGAL were investigated by fluorescence spectrometry and molecular simulation. NGAL fluorescence is quenched regularly when being added with six processing types of tea infusion (SPTT) and ETC. Thermodynamic analyses suggest that ETC with more catechol moieties has a stronger binding capacity with NGAL especially in the presence of Fe . (-)-Epicatechin 3-O-caffeoate (ECC), a natural product isolated from Zijuan green tea, shows the strongest binding ability with NGAL (K = 15.21 ± 8.68 nM in the presence of Fe ). All ETC are effective in protecting nerve cells against H O or Aß induced injury. The inhibitory mechanism of ETC against NGAL supports its potential use in attenuation of neurotoxicity.
[Mh] Termos MeSH primário: Catequina/farmacologia
Lipocalina-2/farmacologia
Chá/química
[Mh] Termos MeSH secundário: Catequina/metabolismo
Interações Medicamentosas
Ésteres
Peróxido de Hidrogênio/farmacologia
Quelantes de Ferro
Lipocalina-2/antagonistas & inibidores
Lipocalina-2/metabolismo
Modelos Moleculares
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores
Espectrometria de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Esters); 0 (Iron Chelating Agents); 0 (Lipocalin-2); 0 (Neuroprotective Agents); 0 (Tea); 8R1V1STN48 (Catechin); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05399



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