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[PMID]:29175405
[Au] Autor:Yang F; Xie S; Liu J; Wei C; Zhang H; Chen T; Zhang J
[Ad] Endereço:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
[Ti] Título:Arsenic concentrations and speciation in wild birds from an abandoned realgar mine in China.
[So] Source:Chemosphere;193:777-784, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Birds are at a higher level in the food chain; however, the potential bioaccumulation and biotransformation of arsenic (As) in birds in As mines has rarely been studied. In this study, four passerine bird species (tree sparrow [Passer montanus], light-vented bulbul [Pycnonotus sinensis], Garrulax canorus [Leucodioptron canorus], and magpie [Pica pica]) were collected from an abandoned As mine in China. The highest recorded As concentrations were 4.95 mg/kg and 51.65 mg/kg in muscles and feathers, respectively. Detection using high-performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) revealed six As species, including arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), arsenobetaine (AsB) and arsenocholine (AsC), with the former three species as the dominant (>92%) and the latter three as the minor As species (<6.17%). Further analysis of the selected bird samples using the X-ray absorption near edge structure (XANES) technique revealed the existence of As(III)-tris-glutathione (As(III)-GSH), which can be regarded as equivalent to the non-extractable and unidentified As form in the HPLC-ICP-MS data. Both methods revealed similar patterns of As species in the birds from the As mine, with muscles containing mainly inorganic As and DMA and feathers containing mainly inorganic As. The results of this study contribute to the knowledge regarding As accumulation and speciation in terrestrial organisms.
[Mh] Termos MeSH primário: Arsênico/análise
Arsenicais/análise
Aves
Mineração
[Mh] Termos MeSH secundário: Animais
Arseniatos
Arsênico/química
Arsenitos
Ácido Cacodílico/análise
China
Cromatografia Líquida de Alta Pressão/métodos
Plumas/química
Espectrometria de Massas/métodos
Músculo Esquelético/química
Passeriformes
Sulfetos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Sulfides); 39895-81-3 (arsenocholine); 56320-22-0 (arsenic disulfide); AJ2HL7EU8K (Cacodylic Acid); J37VJ5709S (monomethylarsonic acid); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid); UWC1LS4V3I (arsenobetaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29231020
[Au] Autor:Qiang HS; Chen H; Shen BH; Shen M; Xiang P
[Ad] Endereço:Pharmacy School of Wenzhou Medical University, Wenzhou 325035, China.
[Ti] Título:[Determination of Sulfide Ion in Blood from Hydrogen Sulfide Poisoning Cases].
[So] Source:Fa Yi Xue Za Zhi;33(2):148-153, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To establish a gas chromatography-mass spectrometry (GC-MS) method for the determination of sulfide ion in blood and apply it to the practical cases. METHODS: The 1, 3, 5-tribromobenzene was selected as an internal standard, and 0.2 mL blood sample was collected and analyzed using GC-MS after α-Bromo-2, 3, 4, 5, 6-pentafluorobenzyl bromide derivatization. RESULTS: The mass concentration of sulfide ion in blood had good linearity in the range of 0.2-40 µg/mL with a limit of detection (LOD) of 0.05 µg/mL. The mass concentration of sulfide ion was less than 0.05 µg/mL in blank blood from different sources such as healthy subjects and dead cases. In 3 sulfide poisoning cases, sulfide ion was detected in the blood samples of 6 victims, and the mass concentration range was 1.02-3.13 µg/mL. CONCLUSIONS: This study establishes a method for investigation of sulfide ion in blood which has been applied successfully to the cases of fatal sulfide poisonings.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Sulfeto de Hidrogênio/sangue
[Mh] Termos MeSH secundário: Fluorbenzenos
Seres Humanos
Limite de Detecção
Sulfetos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorobenzenes); 0 (Sulfides); 1765-40-8 (pentafluorobenzyl bromide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.008


  3 / 13542 MEDLINE  
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[PMID]:28503942
[Au] Autor:Wang ZD; Li LH; Xia H; Wang F; Yang LG; Wang SK; Sun GJ
[Ad] Endereço:a Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition & Food Hygiene, School of Public Health , Southeast University , Nanjing , China.
[Ti] Título:Optimisation of steam distillation extraction oil from onion by response surface methodology and its chemical composition.
[So] Source:Nat Prod Res;32(1):112-115, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oil extraction from onion was performed by steam distillation. Response surface methodology was applied to evaluate the effects of ratio of water to raw material, extraction time, zymolysis temperature and distillation times on yield of onion oil. The maximum extraction yield (1.779%) was obtained as following conditions: ratio of water to raw material was 1, extraction time was 2.5 h, zymolysis temperature was 36° and distillation time was 2.6 h. The experimental values agreed well with those predicted by regression model. The chemical composition of extracted onion oil under the optimum conditions was analysed by gas chromatography-mass spectrometry technology. The results showed that sulphur compounds, like alkanes, sulphide, alkenes, ester and alcohol, were the major components of onion oil.
[Mh] Termos MeSH primário: Destilação/métodos
Cebolas/química
Óleos Vegetais/isolamento & purificação
Sulfetos/isolamento & purificação
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Óleos Vegetais/química
Vapor
Sulfetos/química
Temperatura Ambiente
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 0 (Steam); 0 (Sulfides); 059QF0KO0R (Water); 4P3VLD98FL (onion oil)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1327863


  4 / 13542 MEDLINE  
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[PMID]:29331374
[Au] Autor:Nagahara N; Koike S; Nirasawa T; Kimura H; Ogasawara Y
[Ad] Endereço:Isotope Research Center, Nippon Medical School, Japan. Electronic address: noriyuki@nms.ac.jp.
[Ti] Título:Alternative pathway of H S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase.
[So] Source:Biochem Biophys Res Commun;496(2):648-653, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been known that hydrogen sulfide and/or polysulfides are produced from a (poly)sulfurated sulfur-acceptor substrate of 3-mercaptopyruvate sulfurtransferase (MST) via thioredoxin (Trx) reduction in vitro. In this study, we used thiosulfate as the donor substrate and the catalytic reaction was terminated on the formation of a persulfide or polysulfides. We can present alternative pathway of production of hydrogen sulfide and/or polysulfides from (poly)sulfurated catalytic-site cysteine of reaction intermediates of MST via Trx reduction. Matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometric analysis revealed that after prolonged incubation of MST with thiosulfate, a trisulfide adduct becomes predominant at the sulfurated catalytic-site cysteine. When these adducts were reduced by Trx with reducing system (MST:Escherichia coli Trx:E. coli Trx reductase:NADPH = 1:5:0.02:12.5 molar ratio), liquid chromatography with tandem mass spectrometric analysis for monobromobimane-derivatized H S revealed that H S first appeared, and then H S and H S did later. The results were confirmed by high-performance liquid chromatography-fluorescence analysis.
[Mh] Termos MeSH primário: Cisteína/metabolismo
Sulfeto de Hidrogênio/metabolismo
Sulfetos/metabolismo
Sulfurtransferases/metabolismo
[Mh] Termos MeSH secundário: Animais
Escherichia coli/metabolismo
Proteínas de Escherichia coli/metabolismo
Oxirredução
Ratos
Proteínas Recombinantes/metabolismo
Tiorredoxina Dissulfeto Redutase/metabolismo
Tiorredoxinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Escherichia coli Proteins); 0 (Recombinant Proteins); 0 (Sulfides); 52500-60-4 (Thioredoxins); 9080-49-3 (polysulfide); EC 1.8.1.9 (Thioredoxin-Disulfide Reductase); EC 2.8.1.- (Sulfurtransferases); EC 2.8.1.2 (3-mercaptopyruvate sulphurtransferase); K848JZ4886 (Cysteine); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  5 / 13542 MEDLINE  
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[PMID]:29277370
[Au] Autor:Chand S; Ray S; Wanigasekara E; Yadav P; Crawford JA; Armstrong DW; Rajeshwar K; Pierce BS
[Ad] Endereço:Department of Chemistry and Biochemistry, The University of Texas at Arlington, Texas 76019, USA; Department of Biology, Catholic University of America, Washington DC 20064, USA.
[Ti] Título:Improved rate of substrate oxidation catalyzed by genetically-engineered myoglobin.
[So] Source:Arch Biochem Biophys;639:44-51, 2018 02 01.
[Is] ISSN:1096-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study showcases the potential of unnatural amino acids to enable non-natural functions when incorporated in the protein scaffold of heme metalloproteins. For this purpose, a genetically-engineered myoglobin (Mb) mutant was created by incorporating redox-active 3-amino-l-tyrosine (NH Tyr) into its active site, replacing the distal histidine (H64) with NH Tyr. In peroxide-shunt assays, this variant exhibits an increased rate of turnover for thioanisole and benzaldehyde oxidation as compared to the wild-type (WT) Mb. Indeed, in the presence of excess hydrogen peroxide (H O ), a 9-fold and 81-fold increase in activity was observed over multiple turnovers for thioanisole sulfoxidation and benzoic acid formation, respectively. The increased oxidation activity in the H64NH Tyr Mb mutant underlined the role of NH Tyr in the distal active-site scaffold in peroxide activation. Kinetic, electrochemical, and EPR spectroscopic experiments were performed. On the basis of these studies, it is argued that the single NH Tyr residue within the Mb variant simultaneously serves the role of the conserved His/Arg-pair within the distal pocket of horseradish peroxidase.
[Mh] Termos MeSH primário: Substituição de Aminoácidos
Ácido Benzoico/química
Mioglobina/química
Sulfetos/química
[Mh] Termos MeSH secundário: Animais
Mutação de Sentido Incorreto
Mioglobina/genética
Oxirredução
Cachalote
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Myoglobin); 0 (Sulfides); 8SKN0B0MIM (Benzoic Acid); BB4K737YF4 (methylphenylsulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  6 / 13542 MEDLINE  
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[PMID]:29307179
[Au] Autor:Morroni F; Sita G; Djemil A; D'Amico M; Pruccoli L; Cantelli-Forti G; Hrelia P; Tarozzi A
[Ad] Endereço:Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna , Bologna, Italy.
[Ti] Título:Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.
[So] Source:J Agric Food Chem;66(4):856-865, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several studies suggest that an increase of glutathione (GSH) through activation of the transcriptional nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the dopaminergic neurons may be a promising neuroprotective strategy in Parkinson's disease (PD). Among Nrf2 activators, isothiocyanate sulforaphane (SFN), derived from precursor glucosinolate present in Brassica vegetables, has gained attention as a potential neuroprotective compound. Bioavailability studies also suggest the contribution of SFN metabolites, including erucin (ERN), to the neuroprotective effects of SFN. Therefore, we compared the in vitro neuroprotective effects of SFN and ERN at the same dose level (5 µM) and oxidative treatment with 6-hydroxydopamine (6-OHDA) in SH-SY5Y cells. The pretreatment of SH-SY5Y cells with SFN recorded a higher (p < 0.05) active nuclear Nrf2 protein (12.0 ± 0.4 vs 8.0 ± 0.2 fold increase), mRNA Nrf2 (2.0 ± 0.3 vs 1.4 ± 0.1 fold increase), total GSH (384.0 ± 9.0 vs 256.0 ± 8.0 µM) levels, and resistance to neuronal apoptosis elicited by 6-OHDA compared to ERN. By contrast, the simultaneous treatment of SH-SY5Y cells with either SFN or ERN and 6-OHDA recorded similar neuroprotective effects with both the isothiocyanates (Nrf2 protein 2.2 ± 0.2 vs 2.1 ± 0.1 and mRNA Nrf2 2.1 ± 0.3 vs 1.9 ± 0.2 fold increase; total GSH 384.0 ± 4.8 vs 352.0 ± 6.4 µM). Finally, in vitro finding was confirmed in a 6-OHDA-PD mouse model. The metabolic oxidation of ERN to SFN could account for their similar neuroprotective effects in vivo, raising the possibility of using vegetables containing a precursor of ERN for systemic antioxidant benefits in a similar manner to SFN.
[Mh] Termos MeSH primário: Neurônios Dopaminérgicos/efeitos dos fármacos
Isotiocianatos/farmacologia
Fármacos Neuroprotetores/farmacologia
Doença de Parkinson/prevenção & controle
Sulfetos/farmacologia
Tiocianatos/farmacologia
[Mh] Termos MeSH secundário: Animais
Brassica/química
Linhagem Celular Tumoral
Neurônios Dopaminérgicos/química
Glutationa/análise
Seres Humanos
Isotiocianatos/metabolismo
Isotiocianatos/uso terapêutico
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fator 2 Relacionado a NF-E2/análise
Fator 2 Relacionado a NF-E2/genética
Neuroblastoma
Fármacos Neuroprotetores/uso terapêutico
Oxirredução
Oxidopamina/administração & dosagem
RNA Mensageiro/análise
Sulfetos/metabolismo
Sulfetos/uso terapêutico
Tiocianatos/metabolismo
Tiocianatos/uso terapêutico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isothiocyanates); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Neuroprotective Agents); 0 (RNA, Messenger); 0 (Sulfides); 0 (Thiocyanates); 8HW4YBZ748 (Oxidopamine); CTE370DL3U (erucin); GA49J4310U (sulforafan); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04641


  7 / 13542 MEDLINE  
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[PMID]:29300478
[Au] Autor:Li R; Sun H; Wang S; Wang Y; Yu K
[Ad] Endereço:School of Marine Sciences, Guangxi University , Nanning 530004, P. R. China.
[Ti] Título:Retention of CdS/ZnS Quantum Dots (QDs) on the Root Epidermis of Woody Plant and Its Implications by Benzo[a]pyrene: Evidence from the in Situ Synchronous Nanosecond Time-Resolved Fluorescence Spectra Method.
[So] Source:J Agric Food Chem;66(4):814-821, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The retention of CdS/ZnS QDs on the epidermis has been confirmed to be one of the core procedures during the root uptake process. However, the retention mechanisms of QDs on the epidermis of woody plant were poorly understood for lacking of an appropriate QD quantitative method. In this study, a novel method for in situ determination of CdS/ZnS QDs retained on the root epidermis was established using synchronous nanosecond time-resolved fluorescence spectroscopy. No correlations between K values of oleylamine-CdS/ZnS QDs retained on the epidermal tissues and the surface/bulk composition of mangrove root were observed (p > 0.05) due to the existence of endocytosis mechanisms during the QD uptake processes. Moreover, the difference of the CdS/ZnS QDs in water and further translocated to xylem/phloem of root rather than the combination with cell wall/membranes was the predominant reason that caused the K values to follow the sequence of PEG-COOH-CdS/ZnS QDs < PEG-NH -CdS/ZnS QDs ≪ oleylamine-CdS/ZnS QDs.
[Mh] Termos MeSH primário: Benzo(a)pireno
Compostos de Cádmio/análise
Raízes de Plantas/química
Pontos Quânticos/análise
Espectrometria de Fluorescência/métodos
Sulfetos/análise
Compostos de Zinco/análise
[Mh] Termos MeSH secundário: Avicennia
Compostos de Cádmio/metabolismo
Endocitose
Epiderme/química
Epiderme/metabolismo
Floema/metabolismo
Raízes de Plantas/metabolismo
Pontos Quânticos/metabolismo
Rhizophoraceae
Sulfetos/metabolismo
Água/química
Xilema/metabolismo
Compostos de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cadmium Compounds); 0 (Sulfides); 0 (Zinc Compounds); 057EZR4Z7Q (cadmium sulfide); 059QF0KO0R (Water); 3417WMA06D (Benzo(a)pyrene); KPS085631O (zinc sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04258


  8 / 13542 MEDLINE  
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[PMID]:29239435
[Au] Autor:Li Y; Tang A; Liu Z; Peng L; Yuan Y; Shi X; Yang C; Teng F
[Ad] Endereço:Department of Chemistry, School of Science, Beijing JiaoTong University, Beijing 100044, P. R. China. awtang@bjtu.edu.cn chy@bjtu.edu.cn.
[Ti] Título:Formation of uniform carrot-like Cu S -CuInS heteronanostructures assisted by citric acid at the oil/aqueous interface.
[So] Source:Dalton Trans;47(1):67-73, 2018 Jan 07.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple two-phase strategy was developed to prepare Cu S -CuInS heterostructures (HNS) at the oil/aqueous interface, in which the In(OH) phase was often obtained in the products due to the reaction between indium ions and hydroxyl ions in the aqueous phase. To prevent the formation of the In(OH) phase, citric acid was incorporated into the aqueous phase to assist in the synthesis of uniform carrot-like Cu S -CuInS semiconductor HNS at the oil/aqueous interface for the first time. By manipulating the dosage of citric acid and Cu/In precursor ratios, the morphology of the Cu S -CuInS HNS could be tailored from mushroom to carrot-like, and the presence of citric acid played a critical role in the synthesis of high-quality Cu S -CuInS HNS, which inhibited the formation of the In(OH) phase due to the formation of the indium(iii)-citric acid complex. The formation mechanism was studied by monitoring the morphology and phase evolution of the Cu S -CuInS HNS with reaction time, which revealed that the Cu S seeds were first formed and then the cation-exchange reaction directed the subsequent anisotropic growth of the Cu S -CuInS HNS.
[Mh] Termos MeSH primário: Ácido Cítrico/química
Cobre/química
Índio/química
Óleos/química
Sulfetos/química
Água/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils); 0 (Sulfides); 045A6V3VFX (Indium); 059QF0KO0R (Water); 2968PHW8QP (Citric Acid); 789U1901C5 (Copper)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1039/c7dt04274d


  9 / 13542 MEDLINE  
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[PMID]:29207279
[Au] Autor:Wang L; Chen S; Ding Y; Zhu Q; Zhang N; Yu S
[Ad] Endereço:Department of Pharmacy, Jining No.1 People's Hospital, Jining 272011, Shandong, China. Electronic address: wanglijining@163.com.
[Ti] Título:Biofabrication of morphology improved cadmium sulfide nanoparticles using Shewanella oneidensis bacterial cells and ionic liquid: For toxicity against brain cancer cell lines.
[So] Source:J Photochem Photobiol B;178:424-427, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present work determines the anticancer activity of bio-mediated synthesized cadmium sulfide nanoparticles using the ionic liquid and bacterial cells (Shewanella oneidensis). Bacterial cells have been exposed to be important resources that hold huge potential as ecofriendly, cost-effective, evading toxic of dangerous chemicals and the alternative of conventional physiochemical synthesis. The Shewanella oneidensis is an important kind of metal reducing bacterium, known as its special anaerobic respiratory and sulfate reducing capacity. The crystalline nature, phase purity and surface morphology of biosynthesized cadmium sulfide nanoparticles were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction, Field emission scanning electron microscopy, Energy dispersive spectroscopy and Transmission electron microscopy. The use of imidazolium based ionic liquids as soft templating agent for controlling self-assembly and crystal growth direction of metal sulfide nanoparticles has also advanced as an important method. The microscopic techniques showed that the nanoparticles are designed on the nano form and have an excellent spherical morphology, due to the self-assembled mechanism of ionic liquid assistance. The antitumor efficiency of the cadmium sulfide nanoparticles was investigated against brain cancer cell lines using rat glioma cell lines. The effectively improved nano-crystalline and morphological structure of CdS nanoparticles in the presence of IL exhibit excellent cytotoxicity and dispersion ability on the cell shape is completely spread out showing a nice toxic environment against cancer cells. The cytotoxicity effect of cadmium sulfide nanoparticles was discussed with a diagrammatic representation.
[Mh] Termos MeSH primário: Compostos de Cádmio/química
Líquidos Iônicos/química
Nanopartículas Metálicas/química
Shewanella/química
Sulfetos/química
[Mh] Termos MeSH secundário: Animais
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Líquidos Iônicos/metabolismo
Nanopartículas Metálicas/toxicidade
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Oxirredução
Ratos
Shewanella/metabolismo
Espectrometria por Raios X
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cadmium Compounds); 0 (Ionic Liquids); 0 (Sulfides); 057EZR4Z7Q (cadmium sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:28599858
[Au] Autor:Shalan H; Kato M; Cheruzel L
[Ad] Endereço:San José State University, Department of Chemistry, One Washington Square, San José, CA, United States.
[Ti] Título:Keeping the spotlight on cytochrome P450.
[So] Source:Biochim Biophys Acta;1866(1):80-87, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This review describes the recent advances utilizing photosensitizers and visible light to harness the synthetic potential of P450 enzymes. The structures of the photosensitizers investigated to date are first presented along with their photophysical and redox properties. Functional photosensitizers range from organic and inorganic complexes to nanomaterials as well as the biological photosystem I complex. The focus is then on the three distinct approaches that have emerged for the activation of P450 enzymes. The first approach utilizes the in situ generation of reactive oxygen species entering the P450 mechanism via the peroxide shunt pathway. The other two approaches are sustained by electron injections into catalytically competent heme domains either facilitated by redox partners or through direct heme domain reduction. Achievements as well as pitfalls of each approach are briefly summarized. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone.
[Mh] Termos MeSH primário: Sistema Enzimático do Citocromo P-450/química
Elétrons
Escherichia coli/enzimologia
Heme/química
Complexos de Proteínas Captadores de Luz/química
Fármacos Fotossensibilizantes/química
[Mh] Termos MeSH secundário: Biocatálise
Compostos de Cádmio/química
Sistema Enzimático do Citocromo P-450/metabolismo
Amarelo de Eosina-(YS)/química
Amarelo de Eosina-(YS)/metabolismo
Escherichia coli/química
Escherichia coli/efeitos da radiação
Heme/metabolismo
Luz
Complexos de Proteínas Captadores de Luz/metabolismo
Modelos Moleculares
Oxirredução
Peróxidos/química
Peróxidos/metabolismo
Fármacos Fotossensibilizantes/metabolismo
Estrutura Secundária de Proteína
Pontos Quânticos
Sulfetos/química
Superóxidos/química
Superóxidos/metabolismo
Tioglicolatos/química
Tioglicolatos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW
[Nm] Nome de substância:
0 (Cadmium Compounds); 0 (Light-Harvesting Protein Complexes); 0 (Peroxides); 0 (Photosensitizing Agents); 0 (Sulfides); 0 (Thioglycolates); 057EZR4Z7Q (cadmium sulfide); 11062-77-4 (Superoxides); 42VZT0U6YR (Heme); 7857H94KHM (2-mercaptoacetate); 9035-51-2 (Cytochrome P-450 Enzyme System); TDQ283MPCW (Eosine Yellowish-(YS))
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE



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