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[PMID]:27770357
[Au] Autor:Bilichak A; Kovalchuk I
[Ad] Endereço:Agriculture and Agri-Food Canada, Lethbridge Research Centre, Lethbridge, AB, Canada. andrii.bilichak@agr.gc.ca.
[Ti] Título:The Combined Bisulfite Restriction Analysis (COBRA) Assay for the Analysis of Locus-Specific Changes in Methylation Patterns.
[So] Source:Methods Mol Biol;1456:63-71, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DNA methylation is a heritable but reversible epigenetic mechanism of control over gene expression. The level of DNA methylation of specific genomic regions correlates with chromatin condensation, the level of gene expression, and in some cases genome stability and the frequency of homologous recombination. Here, we describe the combined bisulfite restriction analysis (COBRA) assay that allows analyzing the methylation status at a specific locus. The protocol consists of the following major steps: bisulfite conversion of non-methylated cytosines to uracils, the locus-specific PCR amplification of converted DNA, restriction digestion, the analysis of restriction patterns on the gel, and the quantification of these restriction patterns using ImageJ or a similar program.
[Mh] Termos MeSH primário: Metilação de DNA
Epigenômica
Loci Gênicos
Mapeamento por Restrição/métodos
Análise de Sequência de DNA
Sulfitos
[Mh] Termos MeSH secundário: Epigenômica/métodos
Reação em Cadeia da Polimerase
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfites); OJ9787WBLU (hydrogen sulfite)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29045472
[Au] Autor:Irwin SV; Fisher P; Graham E; Malek A; Robidoux A
[Ad] Endereço:University of Hawaii Maui College, Kahului, Hawaii, United States of America.
[Ti] Título:Sulfites inhibit the growth of four species of beneficial gut bacteria at concentrations regarded as safe for food.
[So] Source:PLoS One;12(10):e0186629, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sulfites and other preservatives are considered food additives to limit bacterial contamination, and are generally regarded as safe for consumption by governmental regulatory agencies at concentrations up to 5000 parts per million (ppm). Consumption of bactericidal and bacteriostatic drugs have been shown to damage beneficial bacteria in the human gut and this damage has been associated with several diseases. In the present study, bactericidal and bacteriostatic effects of two common food preservatives, sodium bisulfite and sodium sulfite, were tested on four known beneficial bacterial species common as probiotics and members of the human gut microbiota. Lactobacillus species casei, plantarum and rhamnosus, and Streptococcus thermophilus were grown under optimal environmental conditions to achieve early log phase at start of experiments. Bacterial cultures were challenged with sulfite concentrations ranging between 10 and 3780 ppm for six hours. To establish a control, a culture of each species was inoculated into media containing no sulfite preservative. By two hours of exposure, a substantial decrease (or no increase) of cell numbers (based on OD600 readings) were observed for all bacteria types, in concentrations of sulfites between 250-500 ppm, compared to cells in sulfite free media. Further testing using serial dilution and drop plates identified bactericidal effects in concentrations ranging between 1000-3780 ppm on all the Lactobacillus species by 4 hours of exposure and bactericidal effects on S. thermophilus in 2000ppm NaHSO3 after 6 hours of exposure.
[Mh] Termos MeSH primário: Bactérias/crescimento & desenvolvimento
Inocuidade dos Alimentos
Microbioma Gastrointestinal/efeitos dos fármacos
Sulfitos/farmacologia
[Mh] Termos MeSH secundário: Bactérias/efeitos dos fármacos
Contagem de Colônia Microbiana
Concentração Inibidora 50
Viabilidade Microbiana/efeitos dos fármacos
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfites); TZX5469Z6I (sodium bisulfite); VTK01UQK3G (sodium sulfite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186629


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[PMID]:28935810
[Au] Autor:Chen S; Huang Y; Liu Z; Yu W; Zhang H; Li K; Yu X; Tang C; Zhao B; Du J; Jin H
[Ad] Endereço:Department of Pediatrics, Peking University First Hospital, Beijing 100034, P.R. China.
[Ti] Título:Sulphur dioxide suppresses inflammatory response by sulphenylating NF-κB p65 at Cys in a rat model of acute lung injury.
[So] Source:Clin Sci (Lond);131(21):2655-2670, 2017 Nov 01.
[Is] ISSN:1470-8736
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate whether endogenous sulphur dioxide (SO ) controlled pulmonary inflammation in a rat model of oleic acid (OA)-induced acute lung injury (ALI). In this model, adenovirus expressing aspartate aminotransferase (AAT) 1 was delivered to the lungs, and the levels of SO and proinflammatory cytokines in rat lung tissues were measured. In the human alveolar epithelial cell line A549, the nuclear translocation and DNA binding activities of wild-type (wt) and C38S (cysteine-to-serine mutation at p65 Cys ) NF-κB p65 were detected. GFP-tagged C38S p65 was purified from HEK 293 cells and the sulphenylation of NF-κB p65 was studied. OA caused a reduction in SO /AAT pathway activity but increased pulmonary inflammation and ALI. However, either the presence of SO donor, a combination of Na SO and NaHSO , or AAT1 overexpression successfully blocked OA-induced pulmonary NF-κB p65 phosphorylation and consequent inflammation and ALI. Either treatment with an SO donor or overexpression of AAT1 down-regulated OA-induced p65 activity, but AAT1 knockdown in alveolar epithelial cells mimicked OA-induced p65 phosphorylation and inflammation Mechanistically, OA promoted NF-κB nuclear translocation, DNA binding activity, recruitment to the intercellular cell adhesion molecule (ICAM)-1 promoter, and consequent inflammation in epithelial cells; these activities were reduced in the presence of an SO donor. Furthermore, SO induced sulphenylation of p65, which was blocked by the C38S mutation on p65 in epithelial cells. Hence, down-regulation of SO /AAT is involved in pulmonary inflammation during ALI. Furthermore, SO suppressed inflammation by sulphenylating NF-κB p65 at Cys .
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/tratamento farmacológico
Anti-Inflamatórios/farmacologia
Pulmão/efeitos dos fármacos
Pneumonia/prevenção & controle
Processamento de Proteína Pós-Traducional/efeitos dos fármacos
Sulfitos/farmacologia
Dióxido de Enxofre/metabolismo
Fator de Transcrição RelA/metabolismo
[Mh] Termos MeSH secundário: Células A549
Lesão Pulmonar Aguda/genética
Lesão Pulmonar Aguda/metabolismo
Lesão Pulmonar Aguda/patologia
Adenoviridae/genética
Animais
Anti-Inflamatórios/metabolismo
Aspartato Aminotransferases/genética
Aspartato Aminotransferases/metabolismo
Sítios de Ligação
Quimiocina CCL2/metabolismo
Cisteína
Modelos Animais de Doenças
Técnicas de Transferência de Genes
Vetores Genéticos
Molécula 1 de Adesão Intercelular/genética
Molécula 1 de Adesão Intercelular/metabolismo
Pulmão/metabolismo
Pulmão/patologia
Ácido Oleico
Fosforilação
Pneumonia/genética
Pneumonia/metabolismo
Pneumonia/patologia
Regiões Promotoras Genéticas
Interferência de RNA
Ratos Wistar
Sulfitos/metabolismo
Fator de Transcrição RelA/genética
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (CCL2 protein, human); 0 (Ccl2 protein, rat); 0 (Chemokine CCL2); 0 (ICAM1 protein, human); 0 (ICAM1 protein, rat); 0 (RELA protein, human); 0 (Rela protein, rat); 0 (Sulfites); 0 (Transcription Factor RelA); 0UZA3422Q4 (Sulfur Dioxide); 126547-89-5 (Intercellular Adhesion Molecule-1); 2UMI9U37CP (Oleic Acid); 91829-63-9 (sodium hydrogen sulfite); EC 2.6.1.1 (Aspartate Aminotransferases); K848JZ4886 (Cysteine); VTK01UQK3G (sodium sulfite)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1042/CS20170274


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[PMID]:28869121
[Au] Autor:Yang M; Wang J; Hou X; Wu J; Fan X; Jiang F; Tao P; Wang F; Peng P; Yang F; Zhang J
[Ad] Endereço:College of Forestry, Northwest A&F University, 3 Taicheng Road, Yangling 712100, China.
[Ti] Título:Exploring surface characterization and electrostatic property of Hybrid Pennisetum during alkaline sulfite pretreatment for enhanced enzymatic hydrolysability.
[So] Source:Bioresour Technol;244(Pt 1):1166-1172, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The surface characterization and electrostatic property of Hybrid Pennisetum (HP) after alkaline sulfite pretreatment were explored for enhanced enzymatic hydrolysability. The O/C ratio in HP increased from 0.34 to 0.60, and C1 concentration decreased from 62.5% to 31.6%, indicating that alkaline sulfite pretreatment caused poorer lignin but richer carbohydrate on HP surface. Zeta potential and sulfur element analysis indicated that more enzymes would preferably adsorb on the carbohydrate surface of alkaline sulfite pretreated HP because the lignin was sulfonated, which facilitated the decrease of non-productive adsorption. Glucose yield of alkaline sulfite pretreated HP reached to 100% by synergistic action of cellulase and xylanase in the hydrolysis, which was significantly higher than that of NaOH pretreated, and the concentration of glucose released was 1.52times higher. The results suggested that alkaline sulfite pretreatment had potential for improving the HP hydrolysability, and the surface characterization and electrostatic property facilitated the enzymatic digestibility.
[Mh] Termos MeSH primário: Pennisetum
Sulfitos
[Mh] Termos MeSH secundário: Celulase
Hidrólise
Lignina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfites); 9005-53-2 (Lignin); EC 3.2.1.4 (Cellulase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28854270
[Au] Autor:Haertle L; Maierhofer A; Böck J; Lehnen H; Böttcher Y; Blüher M; Schorsch M; Potabattula R; El Hajj N; Appenzeller S; Haaf T
[Ad] Endereço:Institute of Human Genetics, Julius Maximilians University, Würzburg, Germany.
[Ti] Título:Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals.
[So] Source:PLoS One;12(8):e0184030, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Imprinted genes show parent-specific activity (functional haploidy), which makes them particularly vulnerable to epigenetic dysregulation. Here we studied the methylation profiles of oppositely imprinted genes at single DNA molecule resolution by two independent parental allele-specific deep bisulfite sequencing (DBS) techniques. Using Roche (GSJunior) next generation sequencing technology, we analyzed the maternally imprinted MEST promoter and the paternally imprinted MEG3 intergenic (IG) differentially methylated region (DMR) in fetal cord blood, adult blood, and visceral adipose tissue. Epimutations were defined as paternal or maternal alleles with >50% aberrantly (de)methylated CpG sites, showing the wrong methylation imprint. The epimutation rates (range 2-66%) of the paternal MEST and the maternal MEG3 IG DMR allele, which should be completely unmethylated, were significantly higher than those (0-15%) of the maternal MEST and paternal MEG3 alleles, which are expected to be fully methylated. This hypermethylation of the non-imprinted allele (HNA) was independent of parental origin. Very low epimutation rates in sperm suggest that HNA occurred after fertilization. DBS with Illumina (MiSeq) technology confirmed HNA for the MEST promoter and the MEG3 IG DMR, and to a lesser extent, for the paternally imprinted secondary MEG3 promoter and the maternally imprinted PEG3 promoter. HNA leads to biallelic methylation of imprinted genes in a considerable proportion of normal body cells (somatic mosaicism) and is highly variable between individuals. We propose that during development and differentiation maintenance of differential methylation at most imprinting control regions may become to some extent redundant. The accumulation of stochastic and environmentally-induced methylation errors on the non-imprinted allele may increase epigenetic diversity between cells and individuals.
[Mh] Termos MeSH primário: Metilação de DNA
Impressão Genômica
Proteínas/genética
RNA Longo não Codificante/genética
[Mh] Termos MeSH secundário: Adulto
Alelos
Epigênese Genética
Feminino
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Masculino
Regiões Promotoras Genéticas
Sulfitos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MEG3 non-coding RNA, human); 0 (Proteins); 0 (RNA, Long Noncoding); 0 (Sulfites); 0 (mesoderm specific transcript protein); OJ9787WBLU (hydrogen sulfite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184030


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[PMID]:28820989
[Au] Autor:Guo X; Wang Y; Wang D
[Ad] Endereço:College of Environmental Science and Engineering, Beijing Key Lab for Source Control Technology of Water Pollution, Beijing Forestry University, Beijing 100083, China.
[Ti] Título:Permanganate/bisulfite (PM/BS) conditioning-horizontal electro-dewatering (HED) of activated sludge: Effect of reactive Mn(III) species.
[So] Source:Water Res;124:584-594, 2017 Nov 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel activated sludge (AS) conditioning method through permanganate/bisulfate (PM/BS) process was proposed. The method involved a new conditioner of reactive Mn(III) intermediate. Moreover, a Mn(III) conditioning-horizontal electro-dewatering (Mn(III) C-HED) process was established to improve AS dewatering performance. Underlying mechanisms were unraveled by investigating changes in physicochemical characteristics, scanning electron microscope (SEM) morphology, and transformation of water and organic matters. The optimum dewatering conditions for Mn(III) C-HED process with the final water content of 86.94% were determined as the combination of KMnO 0.01 mol/L AS and NaHSO 0.05 mol/L AS at 20 V for 120 min. Results showed that Mn(III) C-HED process effectively reduced free water and bound water with the corresponding removal ratios of 51.68% and 87.62% at the anode-side as well as 36.55% and 85.08% at the cathode-side, respectively. During the PM/BS process, the produced Mn(III), Mn , and MnO exerted chemical and physical effects on AS conditioning and dewatering. Mn(III) disintegrated extracellular polymeric substances (EPS) fractions and cells in AS, as well as induced partial bound water release. Additionally, flocculation effect induced by Mn and MnO skeleton building also benefited AS dewatering. AS cells were further disrupted under the effect of a horizontal electric field. Accordingly, EPS within the AS matrix was solubilized, tightly bound (TB)-EPS or loosely bound (LB)-EPS was converted to their corresponding outer EPS fractions, and AS dewaterability improved. Additionally, changes in pH and temperature at HED stage damaged the AS cells and changed the floc properties, thereby leading to easy separation of liquid and AS particles.
[Mh] Termos MeSH primário: Compostos de Manganês
Óxidos
Esgotos
Sulfitos
[Mh] Termos MeSH secundário: Floculação
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); 0 (Sewage); 0 (Sulfites); 059QF0KO0R (Water); 14333-13-2 (permanganic acid); OJ9787WBLU (hydrogen sulfite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


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[PMID]:28763951
[Au] Autor:Roullier-Gall C; Hemmler D; Gonsior M; Li Y; Nikolantonaki M; Aron A; Coelho C; Gougeon RD; Schmitt-Kopplin P
[Ad] Endereço:Analytical Food Chemistry, Technische Universität München, Alte Akademie 10, 85354 Freising-Weihenstephan, Germany; Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
[Ti] Título:Sulfites and the wine metabolome.
[So] Source:Food Chem;237:106-113, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In a context of societal concern about food preservation, the reduction of sulfite input plays a major role in the wine industry. To improve the understanding of the chemistry involved in the SO protection, a series of bottle aged Chardonnay wines made from the same must, but with different concentrations of SO added at pressing were analyzed by ultrahigh resolution mass spectrometry (FT-ICR-MS) and excitation emission matrix fluorescence (EEMF). Metabolic fingerprints from FT-ICR-MS data could discriminate wines according to the added concentration to the must but they also revealed chemistry-related differences according to the type of stopper, providing a wine metabolomics picture of the impact of distinct stopping strategies. Spearman rank correlation was applied to link the statistically modeled EEMF components (parallel factor analysis (PARAFAC)) and the exact mass information from FT-ICR-MS, and thus revealing the extent of sulfur-containing compounds which could show some correlation with fluorescence fingerprints.
[Mh] Termos MeSH primário: Vinho
[Mh] Termos MeSH secundário: Espectrometria de Massas
Metaboloma
Sulfitos
Compostos de Enxofre
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfites); 0 (Sulfur Compounds)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28735739
[Au] Autor:Segovia R; Mathew V; Tam AS; Stirling PC
[Ad] Endereço:Terry Fox Laboratory, BC Cancer Agency, 675 West 10th Ave., Vancouver, Canada.
[Ti] Título:Genome-wide bisulfite sensitivity profiling of yeast suggests bisulfite inhibits transcription.
[So] Source:Mutat Res;821:13-19, 2017 Sep.
[Is] ISSN:1873-135X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bisulfite, in the form of sodium bisulfite or metabisulfite, is used commercially as a food preservative. Bisulfite is used in the laboratory as a single-stranded DNA mutagen in epigenomic analyses of DNA methylation. Recently it has also been used on whole yeast cells to induce mutations in exposed single-stranded regions in vivo. To understand the effects of bisulfite on live cells we conducted a genome-wide screen for bisulfite sensitive mutants in yeast. Screening the deletion mutant array, and collections of essential gene mutants we define a genetic network of bisulfite sensitive mutants. Validation of screen hits revealed hyper-sensitivity of transcription and RNA processing mutants, rather than DNA repair pathways and follow-up analyses support a role in perturbation of RNA transactions. We propose a model in which bisulfite-modified nucleotides may interfere with transcription or RNA metabolism when used in vivo.
[Mh] Termos MeSH primário: Genoma Fúngico
Proteínas de Saccharomyces cerevisiae/genética
Saccharomyces cerevisiae/genética
Sulfitos/toxicidade
Transcrição Genética/efeitos dos fármacos
[Mh] Termos MeSH secundário: Estudo de Associação Genômica Ampla
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saccharomyces cerevisiae Proteins); 0 (Sulfites); OJ9787WBLU (hydrogen sulfite)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE


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[PMID]:28691915
[Au] Autor:Freire-Aradas A; Phillips C; Lareu MV
[Ad] Endereço:Forensic Genetics Unit, Institute of Forensic Sciences, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
[Ti] Título:Forensic individual age estimation with DNA: From initial approaches to methylation tests.
[So] Source:Forensic Sci Rev;29(2):121-144, 2017 Jul.
[Is] ISSN:1042-7201
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:Individual age estimation is a key factor in forensic science analysis that can provide very useful information applicable to criminal, legal, and anthropological investigations. Forensic age inference was initially based on morphological inspection or radiography and only later began to adopt molecular approaches. However, a lack of accuracy or technical problems hampered the introduction of these DNA-based methodologies in casework analysis. A turning point occurred when the epigenetic signature of DNA methylation was observed to gradually change during an individual´s lifespan. In the last four years, the number of publications reporting DNA methylation age-correlated changes has gradually risen and the forensic community now has a range of age methylation tests applicable to forensic casework. Most forensic age predictor models have been developed based on blood DNA samples, but additional tissues are now also being explored. This review assesses the most widely adopted genes harboring methylation sites, detection technologies, statistical age-predictive analyses, and potential causes of variation in age estimates. Despite the need for further work to improve predictive accuracy and establishing a broader range of tissues for which tests can analyze the most appropriate methylation sites, several forensic age predictors have now been reported that provide consistency in their prediction accuracies (predictive error of ±4 years); this makes them compelling tools with the potential to contribute key information to help guide criminal investigations.
[Mh] Termos MeSH primário: Envelhecimento/genética
Metilação de DNA
Genética Forense/métodos
[Mh] Termos MeSH secundário: Acetiltransferases/genética
Amidoidrolases/genética
Ilhas de CpG/genética
Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/genética
Proteína de Domínio de Morte Associada a Edar/genética
Epigenômica
Seres Humanos
Integrina alfa2/genética
Proteínas com Homeodomínio LIM/genética
Proteínas Musculares/genética
Análise de Sequência de DNA
Sulfitos/química
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Edar-Associated Death Domain Protein); 0 (FHL2 protein, human); 0 (ITGA2B protein, human); 0 (Integrin alpha2); 0 (LIM-Homeodomain Proteins); 0 (Muscle Proteins); 0 (Sulfites); 0 (Transcription Factors); EC 2.3.1.- (Acetyltransferases); EC 2.3.1.- (fatty acid elongases); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4); EC 3.1.4.17 (PDE4C protein, human); EC 3.5.- (Amidohydrolases); EC 3.5.1.15 (aspartoacylase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE


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[PMID]:28617409
[Au] Autor:Anisimova EN; Gromovik MV
[Ad] Endereço:Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia.
[Ti] Título:[Safe local anesthesia in patients with bronchial asthma].
[Ti] Título:Osobennosti bezopasnogo mestnogo obezbolivaniia u patsientov s bronkhial'noi astmoi..
[So] Source:Stomatologiia (Mosk);96(3):52-54, 2017.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The paper presents the analysis of studies of local anesthesia in patients with bronchial asthma. It was found that the diagnosis of hypersensitivity to sodium metabisulfite in patients with bronchial asthma must be optimized for development of local anesthesia selection algorithm in outpatient dentistry.
[Mh] Termos MeSH primário: Anestesia Dentária/métodos
Anestesia Local/métodos
Asma/complicações
Broncoconstritores/efeitos adversos
Assistência Odontológica
Hipersensibilidade a Drogas/diagnóstico
Sulfitos/efeitos adversos
[Mh] Termos MeSH secundário: Algoritmos
Anestesia Dentária/efeitos adversos
Anestesia Local/efeitos adversos
Hipersensibilidade a Drogas/complicações
Hipersensibilidade a Drogas/prevenção & controle
Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bronchoconstrictor Agents); 0 (Sulfites); 4VON5FNS3C (sodium metabisulfite)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.17116/stomat201796352-54



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