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[PMID]:28542218
[Au] Autor:Murray MH; Fassina S; Hopkins JB; Whittington J; St Clair CC
[Ad] Endereço:Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Seasonal and individual variation in the use of rail-associated food attractants by grizzly bears (Ursus arctos) in a national park.
[So] Source:PLoS One;12(5):e0175658, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Similar to vehicles on roadways, trains frequently kill wildlife via collisions along railways. Despite the prevalence of this mortality worldwide, little is known about the relative importance of wildlife attractants associated with railways, including spilled agricultural products, enhanced vegetation, invertebrates, and carcasses of rail-killed ungulates. We assessed the relative importance of several railway attractants to a provincially-threatened population of grizzly bears (Ursus arctos) in Banff and Yoho National Parks, Canada, for which rail-caused mortality has increased in recent decades without known cause. We examined the relationship between the use of the railway and diet by fitting 21 grizzly bears with GPS collars in 2011-2013 and measuring the stable isotope values (δ15N, δ34S) derived from their hair. We also examined the importance of rail-associated foods to grizzly bears by analyzing 230 grizzly bear scats collected from May through October in 2012-2014, some of which could be attributed to GPS-collared bears. Among the 21 collared bears, 17 used the rail rarely (<9% of the days they were monitored), and only four bears (which included the three smallest bears and the largest bear in our sample) used the rail frequently (>20% of their monitored days). We found no significant relationships between δ15N and δ34S values measured from the hair of grizzlies and their frequency of rail use. Instead, δ15N increased with body mass, especially for male bears, suggesting large males consumed more animal protein during hair growth. All four bears that used the railway frequently produced scats containing grain. Almost half the scats (43%) collected within 150 m of the railway contained grain compared to only 7% of scats found >150 m from the railway. Scats deposited near the rail were also more likely to contain grain in the fall (85% of scats) compared to summer (14%) and spring (17%), and those containing grain were more diverse in their contents (6.8 ± 2.2 species vs. 4.9 ± 1.6, P < 0.001). Lastly, scats collected near the rail were more likely to contain ungulate hair and ant remains, especially in the summer. Our results support local management knowledge that some bears in the region use the railway to forage and supplement their diets with spilled grain, but that individual use of the railway and associated foods were highly variable. We suggest that managers continue to reduce the risk of bears being killed by trains by reactively removing grain and ungulate carcasses from the railway, reducing the amount of grain spilled by trains, and target mitigation to the specific individuals and locations that attract recurrent rail-based foraging.
[Mh] Termos MeSH primário: Comportamento Alimentar
Parques Recreativos
Ferrovias
Estações do Ano
Ursidae
[Mh] Termos MeSH secundário: Animais
Canadá
Dieta
Grãos Comestíveis
Fezes
Feminino
Cabelo/química
Masculino
Isótopos de Nitrogênio/análise
Isótopos de Enxofre/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Isotopes); 0 (Sulfur Isotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175658


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[PMID]:28299862
[Au] Autor:Gallagher M; Whitehouse MJ; Kamber BS
[Ad] Endereço:Department of Geology, School of Natural Sciences, Trinity College Dublin, Dublin, Ireland.
[Ti] Título:The Neoarchaean surficial sulphur cycle: An alternative hypothesis based on analogies with 20th-century atmospheric lead.
[So] Source:Geobiology;15(3):385-400, 2017 May.
[Is] ISSN:1472-4669
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We revisit the S-isotope systematics of sedimentary pyrite in a shaly limestone from the ca. 2.52 Ga Gamohaan Formation, Upper Campbellrand Subgroup, Transvaal, South Africa. The analysed rock is interpreted to have been deposited in a water depth of ca. 50-100 m, in a restricted sub-basin on a drowning platform. A previous study discovered that the pyrites define a nonzero intercept δ S -Δ S data array. The present study carried out further quadruple S-isotope analyses of pyrite, confirming and expanding the linear δ S -Δ S array with an δ S zero intercept at ∆ S ca. +5. This was previously interpreted to indicate mixing of unrelated S-sources in the sediment environment, involving a combination of recycled sulphur from sulphides that had originally formed by sulphate-reducing bacteria, along with elemental sulphur. Here, we advance an alternative explanation based on the recognition that the Archaean seawater sulphate concentration was likely very low, implying that the Archaean ocean could have been poorly mixed with respect to sulphur. Thus, modern oceanic sulphur systematics provide limited insight into the Archaean sulphur cycle. Instead, we propose that the 20th-century atmospheric lead event may be a useful analogue. Similar to industrial lead, the main oceanic input of Archaean sulphur was through atmospheric raindown, with individual giant point sources capable of temporally dominating atmospheric input. Local atmospheric S-isotope signals, of no global significance, could thus have been transmitted into the localised sediment record. Thus, the nonzero intercept δ S -Δ S data array may alternatively represent a very localised S-isotope signature in the Neoarchaean surface environment. Fallout from local volcanic eruptions could imprint recycled MIF-S signals into pyrite of restricted depositional environments, thereby avoiding attenuation of the signal in the subdued, averaged global open ocean sulphur pool. Thus, the superposition of extreme local S-isotope signals offers an alternative explanation for the large Neoarchaean MIF-S excursions and asymmetry of the Δ S rock record.
[Mh] Termos MeSH primário: Carbonato de Cálcio/química
Sedimentos Geológicos/química
Fenômenos Geológicos
Ferro/química
Sulfetos/química
Isótopos de Enxofre/análise
[Mh] Termos MeSH secundário: África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfides); 0 (Sulfur Isotopes); 132N09W4PR (pyrite); E1UOL152H7 (Iron); H0G9379FGK (Calcium Carbonate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1111/gbi.12234


  3 / 3374 MEDLINE  
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[PMID]:28248995
[Au] Autor:Mowat G; Curtis PJ; Lafferty DJ
[Ad] Endereço:Natural Resource Science Section, BC Ministry of Forests, Lands and Natural Resource Operations, Nelson, British Columbia, Canada.
[Ti] Título:The influence of sulfur and hair growth on stable isotope diet estimates for grizzly bears.
[So] Source:PLoS One;12(3):e0172194, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stable isotope ratios of grizzly bear (Ursus arctos) guard hair collected from bears on the lower Stikine River, British Columbia (BC) were analyzed to: 1) test whether measuring δ34S values improved the precision of the salmon (Oncorhynchus spp.) diet fraction estimate relative to δ15N as is conventionally done, 2) investigate whether measuring δ34S values improves the separation of diet contributions of moose (Alces alces), marmot (Marmota caligata), and mountain goat (Oreamnos americanus) and, 3) examine the relationship between collection date and length of hair and stable isotope values. Variation in isotope signatures among hair samples from the same bear and year were not trivial. The addition of δ34S values to mixing models used to estimate diet fractions generated small improvement in the precision of salmon and terrestrial prey diet fractions. Although the δ34S value for salmon is precise and appears general among species and areas, sulfur ratios were strongly correlated with nitrogen ratios and therefore added little new information to the mixing model regarding the consumption of salmon. Mean δ34S values for the three terrestrial herbivores of interest were similar and imprecise, so these data also added little new information to the mixing model. The addition of sulfur data did confirm that at least some bears in this system ate marmots during summer and fall. We show that there are bears with short hair that assimilate >20% salmon in their diet and bears with longer hair that eat no salmon living within a few kilometers of one another in a coastal ecosystem. Grizzly bears are thought to re-grow hair between June and October however our analysis of sectioned hair suggested at least some hairs begin growing in July or August, not June and, that hair of wild bears may grow faster than observed in captive bears. Our hair samples may have been from the year of sampling or the previous year because samples were collected in summer when bears were growing new hair. The salmon diet fraction increased with later hair collection dates, as expected if samples were from the year of sampling because salmon began to arrive in mid-summer. Bears that ate salmon had shorter hair and δ15N and δ34S values declined with hair length, also suggesting some hair samples were grown the year of sampling. To be sure to capture an entire hair growth period, samples must be collected in late fall. Early spring samples are also likely to be from the previous year but the date when hair begins to grow appears to vary. Choosing the longest hair available should increase the chance the hair was grown during the previous year and, maximize the period for which diet is measured.
[Mh] Termos MeSH primário: Comportamento Alimentar/fisiologia
Preferências Alimentares/fisiologia
Cabelo/crescimento & desenvolvimento
Estações do Ano
Enxofre/metabolismo
Ursidae/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Cabelo/metabolismo
Masculino
Isótopos de Enxofre/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfur Isotopes); 70FD1KFU70 (Sulfur)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172194


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[PMID]:28128527
[Au] Autor:Meyer NR; Zerkle AL; Fike DA
[Ad] Endereço:School of Earth and Environmental Sciences, University of St Andrews, St Andrews, UK.
[Ti] Título:Sulphur cycling in a Neoarchaean microbial mat.
[So] Source:Geobiology;15(3):353-365, 2017 May.
[Is] ISSN:1472-4669
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Multiple sulphur (S) isotope ratios are powerful proxies to understand the complexity of S biogeochemical cycling through Deep Time. The disappearance of a sulphur mass-independent fractionation (S-MIF) signal in rocks <~2.4 Ga has been used to date a dramatic rise in atmospheric oxygen levels. However, intricacies of the S-cycle before the Great Oxidation Event remain poorly understood. For example, the isotope composition of coeval atmospherically derived sulphur species is still debated. Furthermore, variation in Archaean pyrite δ S values has been widely attributed to microbial sulphate reduction (MSR). While petrographic evidence for Archaean early-diagenetic pyrite formation is common, textural evidence for the presence and distribution of MSR remains enigmatic. We combined detailed petrographic and in situ, high-resolution multiple S-isotope studies (δ S and Δ S) using secondary ion mass spectrometry (SIMS) to document the S-isotope signatures of exceptionally well-preserved, pyritised microbialites in shales from the ~2.65-Ga Lokammona Formation, Ghaap Group, South Africa. The presence of MSR in this Neoarchaean microbial mat is supported by typical biogenic textures including wavy crinkled laminae, and early-diagenetic pyrite containing <26‰ µm-scale variations in δ S and Δ S = -0.21 ± 0.65‰ (±1σ). These large variations in δ S values suggest Rayleigh distillation of a limited sulphate pool during high rates of MSR. Furthermore, we identified a second, morphologically distinct pyrite phase that precipitated after lithification, with δ S = 8.36 ± 1.16‰ and Δ S = 5.54 ± 1.53‰ (±1σ). We propose that the S-MIF signature of this secondary pyrite does not reflect contemporaneous atmospheric processes at the time of deposition; instead, it formed by the influx of later-stage sulphur-bearing fluids containing an inherited atmospheric S-MIF signal and/or from magnetic isotope effects during thermochemical sulphate reduction. These insights highlight the complementary nature of petrography and SIMS studies to resolve multigenerational pyrite formation pathways in the geological record.
[Mh] Termos MeSH primário: Fósseis
Sedimentos Geológicos/química
Sedimentos Geológicos/microbiologia
Ferro/metabolismo
Sulfetos/metabolismo
Enxofre/metabolismo
[Mh] Termos MeSH secundário: Geologia
Espectrometria de Massas
África do Sul
Isótopos de Enxofre/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfides); 0 (Sulfur Isotopes); 132N09W4PR (pyrite); 70FD1KFU70 (Sulfur); E1UOL152H7 (Iron)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1111/gbi.12227


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[PMID]:28088848
[Au] Autor:Willacker JJ; Eagles-Smith CA; Ackerman JT
[Ad] Endereço:U.S. Geological Survey, Forest and Rangeland Ecosystem Science Center , Corvallis Research Group, 3200 SW Jefferson Way, Corvallis, Oregon 97331, United States.
[Ti] Título:Mercury Bioaccumulation in Estuarine Fishes: Novel Insights from Sulfur Stable Isotopes.
[So] Source:Environ Sci Technol;51(4):2131-2139, 2017 Feb 21.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Estuaries are transitional habitats characterized by complex biogeochemical and ecological gradients that result in substantial variation in fish total mercury concentrations (THg). We leveraged these gradients and used carbon (δ C), nitrogen (δ N), and sulfur (δ S) stable isotopes to examine the ecological and biogeochemical processes underlying THg bioaccumulation in fishes from the San Francisco Bay Estuary. We employed a tiered approach that first examined processes influencing variation in fish THg among wetlands, and subsequently examined the roles of habitat and within-wetland processes in generating larger-scale patterns in fish THg. We found that δ S, an indicator of sulfate reduction and habitat specific-foraging, was correlated with fish THg at all three spatial scales. Over the observed ranges of δ S, THg concentrations in fish increased by up to 860% within wetlands, 560% among wetlands, and 291% within specific impounded wetland habitats. In contrast, δ C and δ N were not correlated with THg among wetlands and were only important in low salinity impounded wetlands, possibly reflecting more diverse food webs in this habitat. Together, our results highlight the key roles of sulfur biogeochemistry and ecology in influencing estuarine fish THg, as well as the importance of fish ecology and habitat in modulating the relationships between biogeochemical processes and Hg bioaccumulation.
[Mh] Termos MeSH primário: Mercúrio
Enxofre
[Mh] Termos MeSH secundário: Animais
Monitoramento Ambiental
Peixes
Cadeia Alimentar
Isótopos de Enxofre
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfur Isotopes); 0 (Water Pollutants, Chemical); 70FD1KFU70 (Sulfur); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b05325


  6 / 3374 MEDLINE  
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[PMID]:28046021
[Au] Autor:Yohannes E; Grimm C; Rothhaupt KO; Behrmann-Godel J
[Ad] Endereço:Limnological Institute, University of Konstanz, Mainaustrasse 252, Konstanz, Germany.
[Ti] Título:The Effect of Parasite Infection on Stable Isotope Turnover Rates of δ15N, δ13C and δ34S in Multiple Tissues of Eurasian Perch Perca fluviatilis.
[So] Source:PLoS One;12(1):e0169058, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stable isotope analysis of commercially and ecologically important fish can improve understanding of life-history and trophic ecology. However, accurate interpretation of stable isotope values requires knowledge of tissue-specific isotopic turnover that will help to describe differences in the isotopic composition of tissues and diet. We performed a diet-switch experiment using captive-reared parasite-free Eurasian perch (Perca fluviatilis) and wild caught specimens of the same species, infected with the pike tapeworm Triaenophorus nodulosus living in host liver tissue. We hypothesize that metabolic processes related to infection status play a major role in isotopic turnover and examined the influence of parasite infection on isotopic turn-over rate of carbon (δ13C), nitrogen (δ15N) and sulphur (δ34S) in liver, blood and muscle. The δ15N and δ13C turnovers were fastest in liver tissues, followed by blood and muscle. In infected fish, liver and blood δ15N and δ13C turnover rates were similar. However, in infected fish, liver and blood δ13C turnover was faster than that of δ15N. Moreover, in infected subjects, liver δ15N and δ13C turnover rates were three to five times faster than in livers of uninfected subjects (isotopic half-life of ca.3-4 days compared to 16 and 10 days, respectively). Blood δ34S turnover rate were about twice faster in non-infected individuals implying that parasite infection could retard the turnover rate of δ34S and sulphur containing amino acids. Slower turnover rate of essential amino acid could probably decrease individual immune function. These indicate potential hidden costs of chronic and persistent infections that may have accumulated adverse effects and might eventually impair life-history fitness. For the first time, we were able to shift the isotope values of parasites encapsulated in the liver by changing the dietary source of the host. We also report variability in isotopic turnover rates between tissues, elements and between infected and parasite-free individuals. These results contribute to our understanding of data obtained from field and commercial hatcheries; and strongly improve the applicability of the stable isotope method in understanding life-history and trophic ecology of fish populations.
[Mh] Termos MeSH primário: Isótopos de Carbono/análise
Cestoides
Infecções por Cestoides/metabolismo
Isótopos de Nitrogênio/análise
Percas/metabolismo
Percas/parasitologia
Isótopos de Enxofre/análise
[Mh] Termos MeSH secundário: Ração Animal
Animais
Comportamento Alimentar
Feminino
Meia-Vida
Lipídeos/sangue
Fígado/parasitologia
Masculino
Músculos/parasitologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (Lipids); 0 (Nitrogen Isotopes); 0 (Sulfur Isotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169058


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[PMID]:27908409
[Au] Autor:Galilea San Blas O; Moreno Sanz F; Herrero Espílez P; Sainz Menéndez RM; Mayo Barallo JC; Marchante-Gayón JM; García Alonso JI
[Ad] Endereço:Department of Physical and Analytical Chemistry, University of Oviedo, Julian Clavería 8, 33006 Oviedo, Spain.
[Ti] Título:Evaluation of sulfur isotopic enrichment of urine metabolites for the differentiation of healthy and prostate cancer mice after the administration of S labelled yeast.
[So] Source:J Trace Elem Med Biol;39:155-161, 2017 Jan.
[Is] ISSN:1878-3252
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sulfur isotopic enrichment of urine metabolites in healthy and prostate cancer mice using S enriched yeast and High Performance Liquid Chromatography coupled to Multicollector Inductively Coupled Plasma Mass Spectrometry (HPLC-MC-ICP-MS) has been evaluated. A 30 weeks experiment (since the eleventh to the fortieth week of life) was carried out collecting the urine of three healthy mice and three transgenic mice with prostate cancer during 24h after a single oral administration of a S enriched yeast slurry. The isotopic enrichment of different sulphur metabolites was monitored by coupling a C18 reverse phase HPLC column with a multicollector ICP-MS using a membrane desolvating system. Quantification of sulfur in the chromatographic peaks was carried out by post-column isotope dilution using a S enriched spike. Differences between the S enrichment in the urine metabolites of healthy and prostate cancer mice were found from the beginning of the disease. Both populations could be differentiated using a principal component analysis (PCA). Finally, 7 unknown mice were correctly classified in each population using a linear discriminant analysis.
[Mh] Termos MeSH primário: Ração Animal/análise
Saúde
Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/urina
Saccharomyces cerevisiae/química
Isótopos de Enxofre/metabolismo
Isótopos de Enxofre/urina
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Masculino
Espectrometria de Massas
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Análise de Componente Principal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfur Isotopes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170812
[Lr] Data última revisão:
170812
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:27801563
[Au] Autor:Xu W; Wang X; Tocker AM; Huang P; Reith ME; Liu-Chen LY; Smith AB; Kortagere S
[Ti] Título:Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists.
[So] Source:ACS Chem Neurosci;8(3):486-500, 2017 Mar 15.
[Is] ISSN:1948-7193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dopamine receptors play an integral role in controlling brain physiology. Importantly, subtype selective agonists and antagonists of dopamine receptors with biased signaling properties have been successful in treating psychiatric disorders with a low incidence of side effects. To this end, we recently designed and developed SK609, a dopamine D3 receptor (D3R) selective agonist that has atypical signaling properties. SK609 has shown efficacy in reversing akinesia and reducing L-dopa-induced dyskinesia in a hemiparkinsonian rats. In the current study, we demonstrate that SK609 has high selectivity for D3R with no binding affinity on D2R high- or low-affinity state when tested at a concentration of 10 µM. In addition, SK609 and its analogues do not induce desensitization of D3R as determined by repeated agonist treatment response in phosphorylation of ERK1/2 functional assay. Most significantly, SK609 and its analogues preferentially signal through the G-protein-dependent pathway and do not recruit ß-arrestin-2, suggesting a functional bias toward the G-protein-dependent pathway. Structure-activity relationship (SAR) studies using analogues of SK609 demonstrate that the molecules bind at the orthosteric site by maintaining the conserved salt bridge interactions with aspartate 110 on transmembrane 3 and aryl interactions with histidine 349 on transmembrane 6, in addition to several hydrophobic interactions with residues from transmembranes 5 and 6. The compounds follow a strict SAR with reference to the three pharmacophore elements: substituted phenyl ring, length of the linker connecting phenyl ring and amine group, and orientation and hydrophobic branching groups at the amine among SK609 analogues for efficacy and functional selectivity. These features of SK609 and the analogues suggest that biased signaling is an inherent property of this series of molecules.
[Mh] Termos MeSH primário: Butilaminas/química
Butilaminas/farmacologia
Receptores de Dopamina D3/agonistas
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Benzazepinas/farmacocinética
Células CHO
Cricetulus
Antagonistas de Dopamina/farmacocinética
Antagonistas de Dopamina/farmacologia
Guanosina 5'-O-(3-Tiotrifosfato)/farmacocinética
Células HEK293
Seres Humanos
Modelos Moleculares
Simulação de Acoplamento Molecular
Fosforilação/efeitos dos fármacos
Fosforilação/genética
Ligação Proteica/efeitos dos fármacos
Receptores de Dopamina D2/genética
Receptores de Dopamina D2/metabolismo
Receptores de Dopamina D3/genética
Receptores de Dopamina D3/metabolismo
Transdução de Sinais/genética
Isótopos de Enxofre/farmacocinética
Transfecção
Trítio/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-(2-chlorophenyl)butan-2-amine); 0 (Benzazepines); 0 (Butylamines); 0 (Dopamine Antagonists); 0 (Receptors, Dopamine D2); 0 (Receptors, Dopamine D3); 0 (SCH 23390); 0 (Sulfur Isotopes); 10028-17-8 (Tritium); 37589-80-3 (Guanosine 5'-O-(3-Thiotriphosphate))
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE
[do] DOI:10.1021/acschemneuro.6b00221


  9 / 3374 MEDLINE  
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[PMID]:27648524
[Au] Autor:Clayden MG; Lescord GL; Kidd KA; Wang X; Muir DC; O'Driscoll NJ
[Ad] Endereço:Canadian Rivers Institute and Biology Department, University of New Brunswick, Saint John, New Brunswick, Canada.
[Ti] Título:Using sulfur stable isotopes to assess mercury bioaccumulation and biomagnification in temperate lake food webs.
[So] Source:Environ Toxicol Chem;36(3):661-670, 2017 Mar.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrogen and carbon stable isotopes (δ N, δ C) are commonly used to understand mercury (Hg) bioaccumulation and biomagnification in freshwater food webs. Though sulfur isotopes (δ S) can distinguish between energy sources from the water column (aqueous sulfate) and from sediments to freshwater organisms, little is known about whether δ S can help interpret variable Hg concentrations in aquatic species or food webs. Seven acidic lakes in Kejimkujik National Park (Nova Scotia, Canada) were sampled for biota, water, and sediments in 2009 and 2010. Fishes, zooplankton, and macroinvertebrates were analyzed for δ S, δ N, δ C, and Hg (methyl Hg in invertebrates, total Hg in fishes); aqueous sulfate and profundal sediments were analyzed for δ S. Within lakes, mean δ S values in sediments and sulfate differed between 0.53‰ and 1.98‰, limiting their use as tracers of energy sources to the food webs. However, log-Hg and δ S values were negatively related (slopes -0.14 to -0.35, R 0.20-0.39, p < 0.001-0.01) through each food web, and slopes were significantly different among lakes (analysis of covariance, lake × Î´ S interaction term p = 0.04). Despite these relationships, multiple regression analyses within each taxon showed that biotic Hg concentrations were generally better predicted by δ N and/or δ C. The results indicate that δ S values are predictive of Hg concentrations in these food webs, although the mechanisms underlying these relationships warrant further study. Environ Toxicol Chem 2017;36:661-670. © 2016 SETAC.
[Mh] Termos MeSH primário: Organismos Aquáticos/metabolismo
Monitoramento Ambiental/métodos
Lagos/química
Mercúrio/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos/efeitos dos fármacos
Peixes/metabolismo
Cadeia Alimentar
Invertebrados/efeitos dos fármacos
Invertebrados/metabolismo
Mercúrio/análise
Nova Escócia
Isótopos de Enxofre
Poluentes Químicos da Água/análise
Zooplâncton/efeitos dos fármacos
Zooplâncton/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfur Isotopes); 0 (Water Pollutants, Chemical); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3615


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[PMID]:27459328
[Au] Autor:Nakabayashi R; Saito K
[Ad] Endereço:RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: ryo.nakabayashi@riken.jp.
[Ti] Título:Ultrahigh resolution metabolomics for S-containing metabolites.
[So] Source:Curr Opin Biotechnol;43:8-16, 2017 Feb.
[Is] ISSN:1879-0429
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The advent of the genome-editing era greatly increases the opportunities for synthetic biology research that aims to enhance production of potentially useful bioactive metabolites in heterologous hosts. A wide variety of sulfur (S)-containing metabolites (S-metabolites) are known to possess bioactivities and health-promoting properties, but finding them and their chemical assignment using mass spectrometry-based metabolomics has been difficult. In this review, we highlight recent advances on the targeted metabolomic analysis of S-metabolites (S-omics) in plants using ultrahigh resolution mass spectrometry. The use of exact mass and signal intensity differences between S-containing monoisotopic ions and counterpart S isotopic ions exploits an entirely new method to characterize S-metabolites. Finally, we discuss the availability of S-omics for synthetic biology.
[Mh] Termos MeSH primário: Espectrometria de Massas/métodos
Metaboloma
Metabolômica/métodos
Plantas/metabolismo
Isótopos de Enxofre/análise
Enxofre/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Sulfur Isotopes); 70FD1KFU70 (Sulfur)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE



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