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  1 / 22155 MEDLINE  
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[PMID]:28970007
[Au] Autor:Preissler J; Wahlefeld S; Lorent C; Teutloff C; Horch M; Lauterbach L; Cramer SP; Zebger I; Lenz O
[Ad] Endereço:Technische Universität Berlin, Institut für Chemie, Sekr. PC14, Straße des 17. Juni 135, D-10623 Berlin, Germany.
[Ti] Título:Enzymatic and spectroscopic properties of a thermostable [NiFe]­hydrogenase performing H -driven NAD -reduction in the presence of O .
[So] Source:Biochim Biophys Acta;1859(1):8-18, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Biocatalysts that mediate the H -dependent reduction of NAD to NADH are attractive from both a fundamental and applied perspective. Here we present the first biochemical and spectroscopic characterization of an NAD -reducing [NiFe]­hydrogenase that sustains catalytic activity at high temperatures and in the presence of O , which usually acts as an inhibitor. We isolated and sequenced the four structural genes, hoxFUYH, encoding the soluble NAD -reducing [NiFe]­hydrogenase (SH) from the thermophilic betaproteobacterium, Hydrogenophilus thermoluteolus TH-1 (Ht). The HtSH was recombinantly overproduced in a hydrogenase-free mutant of the well-studied, H -oxidizing betaproteobacterium Ralstonia eutropha H16 (Re). The enzyme was purified and characterized with various biochemical and spectroscopic techniques. Highest H -mediated NAD reduction activity was observed at 80°C and pH6.5, and catalytic activity was found to be sustained at low O concentrations. Infrared spectroscopic analyses revealed a spectral pattern for as-isolated HtSH that is remarkably different from those of the closely related ReSH and other [NiFe]­hydrogenases. This indicates an unusual configuration of the oxidized catalytic center in HtSH. Complementary electron paramagnetic resonance spectroscopic analyses revealed spectral signatures similar to related NAD -reducing [NiFe]­hydrogenases. This study lays the groundwork for structural and functional analyses of the HtSH as well as application of this enzyme for H -driven cofactor recycling under oxic conditions at elevated temperatures.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Cupriavidus necator/enzimologia
Temperatura Alta
Hidrogênio/química
Hidrogenase/química
Hydrogenophilaceae/enzimologia
NAD/química
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Cupriavidus necator/genética
Estabilidade Enzimática
Hidrogênio/metabolismo
Hidrogenase/genética
Hidrogenase/metabolismo
Hydrogenophilaceae/genética
NAD/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0U46U6E8UK (NAD); 7YNJ3PO35Z (Hydrogen); EC 1.12.- (nickel-iron hydrogenase); EC 1.12.7.2 (Hydrogenase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


  2 / 22155 MEDLINE  
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[PMID]:28919500
[Au] Autor:Mebs S; Kositzki R; Duan J; Kertess L; Senger M; Wittkamp F; Apfel UP; Happe T; Stripp ST; Winkler M; Haumann M
[Ad] Endereço:Department of Physics, Biophysics of Metalloenzymes, Freie Universität Berlin, 14195 Berlin, Germany.
[Ti] Título:Hydrogen and oxygen trapping at the H-cluster of [FeFe]-hydrogenase revealed by site-selective spectroscopy and QM/MM calculations.
[So] Source:Biochim Biophys Acta;1859(1):28-41, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:[FeFe]-hydrogenases are superior hydrogen conversion catalysts. They bind a cofactor (H-cluster) comprising a four-iron and a diiron unit with three carbon monoxide (CO) and two cyanide (CN ) ligands. Hydrogen (H ) and oxygen (O ) binding at the H-cluster was studied in the C169A variant of [FeFe]-hydrogenase HYDA1, in comparison to the active oxidized (Hox) and CO-inhibited (Hox-CO) species in wildtype enzyme. Fe labeling of the diiron site was achieved by in vitro maturation with a synthetic cofactor analogue. Site-selective X-ray absorption, emission, and nuclear inelastic/forward scattering methods and infrared spectroscopy were combined with quantum chemical calculations to determine the molecular and electronic structure and vibrational dynamics of detected cofactor species. Hox reveals an apical vacancy at Fe in a [4Fe4S-2Fe] complex with the net spin on Fe whereas Hox-CO shows an apical CN at Fe in a [4Fe4S-2Fe(CO)] complex with net spin sharing among Fe and Fe (proximal or distal iron ions in [2Fe]). At ambient O pressure, a novel H-cluster species (Hox-O ) accumulated in C169A, assigned to a [4Fe4S-2Fe(O )] complex with an apical superoxide (O ) carrying the net spin bound at Fe . H exposure populated the two-electron reduced Hhyd species in C169A, assigned as a [(H)4Fe4S-2Fe(H)] complex with the net spin on the reduced cubane, an apical hydride at Fe , and a proton at a cysteine ligand. Hox-O and Hhyd are stabilized by impaired O protonation or proton release after H cleavage due to interruption of the proton path towards and out of the active site.
[Mh] Termos MeSH primário: Chlamydomonas reinhardtii/enzimologia
Hidrogênio/química
Hidrogenase/química
Proteínas com Ferro-Enxofre/química
Oxigênio/química
Proteínas de Plantas/química
[Mh] Termos MeSH secundário: Domínio Catalítico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iron-Sulfur Proteins); 0 (Plant Proteins); 7YNJ3PO35Z (Hydrogen); EC 1.12.7.2 (Hydrogenase); S88TT14065 (Oxygen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


  3 / 22155 MEDLINE  
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[PMID]:29215959
[Au] Autor:Garcia-Peña EI; Niño-Navarro C; Chairez I; Torres-Bustillos L; Ramírez-Muñoz J; Salgado-Manjarrez E
[Ad] Endereço:a Department of Bioprocesses , Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional , Mexico City , Mexico.
[Ti] Título:Performance intensification of a stirred bioreactor for fermentative biohydrogen production.
[So] Source:Prep Biochem Biotechnol;48(1):64-74, 2018 Jan 02.
[Is] ISSN:1532-2297
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the biohydrogen (bioH ) production of a microbial consortium was optimized by adjusting the type and configuration of two impellers, the mixing regimen and the mass transfer process (K a coefficients). A continuous stirred-tank reactor (CSTR) system, with a nonstandard geometry, was characterized. Two different mixing configurations with either predominant axial (PB4 impeller) or radial pumping (Rushton impeller) were assessed and four different impeller configurations to produce bioH . The best configuration for an adequate mixing time was determined by an ANOVA analysis. A response surface methodology was also used to fully elucidate the optimal configuration. When the PB4 impellers were placed in best configuration, c/Dt = 0.5, s/Di = 1, the maximum bioH productivity obtained was 440 mL L hr , with a bioH molar yield of 1.8. The second best configuration obtained with the PB4 impellers presented a bioH productivity of 407.94 mL L hr . The configurations based on Rushton impellers showed a lower bioH productivity and bioH molar yield of 177.065 mL L hr and 0.71, respectively. The experiments with axial impellers (PB4) showed the lowest K a coefficient and the highest bioH production, suggesting that mixing is more important than K a for the enhanced production of bioH
[Mh] Termos MeSH primário: Reatores Biológicos
Hidrogênio/metabolismo
Microbiologia Industrial/instrumentação
[Mh] Termos MeSH secundário: Análise de Variância
Reatores Biológicos/microbiologia
Desenho de Equipamento
Fermentação
Hidrodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1080/10826068.2017.1405269


  4 / 22155 MEDLINE  
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[PMID]:29288664
[Au] Autor:Wu J; Wang R; Yang D; Tang W; Chen Z; Sun Q; Liu L; Zang R
[Ad] Endereço:Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
[Ti] Título:Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway.
[So] Source:Biochem Biophys Res Commun;495(4):2462-2468, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H ) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the right eyes of rats and was followed by inhalation of 67% H mixed with 33% oxygen immediately after ischemia for 1 h daily for one week. RGC density was counted using haematoxylin and eosin (HE) staining, retrograde labelling with cholera toxin beta (CTB) and TUNEL staining, respectively. Visual function was assessed using flash visual evoked potentials (FVEP) and pupillary light reflex (PLR). The phosphorylated Akt was analysed by RT-PCR and western blot. The results showed that administration of HPC significantly inhibited the apoptosis of RGCs and protected the visual function. Simultaneously, HPC treatment markedly increased the phosphorylations of Akt. Blockade of PI3K activity by inhibitors (LY294002) dramatically abolished its anti-apoptotic effect and lowered both visual function and Akt phosphorylation levels. Taken together, our results demonstrate that HPC appears to confer neuroprotection against retinal IRI via the PI3K/Akt pathway.
[Mh] Termos MeSH primário: Hidrogênio/administração & dosagem
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Traumatismo por Reperfusão/tratamento farmacológico
Traumatismo por Reperfusão/metabolismo
Células Ganglionares da Retina/metabolismo
Vasos Retinianos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração por Inalação
Animais
Sobrevivência Celular
Masculino
Ratos Sprague-Dawley
Traumatismo por Reperfusão/patologia
Células Ganglionares da Retina/efeitos dos fármacos
Células Ganglionares da Retina/patologia
Vasos Retinianos/patologia
Transdução de Sinais/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
7YNJ3PO35Z (Hydrogen); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  5 / 22155 MEDLINE  
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[PMID]:29251900
[Au] Autor:Liu W; Yuan L; Wei B
[Ti] Título:Study on improvement of continuous hydrogen production by photosynthetic biofilm in interior illuminant reactor.
[So] Source:J Environ Biol;37(5):999-1006, 2016 09.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:In the present study, a new type of interior optical fiber illuminating reactor was developed for H2 production to solve the problem of luminous intensity attenuation at the center portion of a reactor, and an immobilization technique was used to enhance the stability of a continuous hydrogen production process with attached photosynthetic bacteria, using glucose as a sole carbon substrate for the indigenous photosynthetic bacteria (PSB) Rhodopseudomonas palustris SP-6. Results of the experiments showed that the interior optical fiber illuminating reactor produces H2 more efficiently and productively than the exterior light source reactor, with the cumulative H2 production, the maximum H2 production rate and H2 yield increased by 813ml, 11.3ml l-1 h-1 and 22.3%, respectively. The stability of the product of continuous hydrogen was realized by immobilizing PSB on the surface of powder active carbon(PAC). After adding the dosage of 2.0g l-1 PAC, the continuous steady operation of H2 production gave a high H2 yield of 1.398 mol H2 mol-1 glucose and an average H2 production rate of 35.1ml l-1 h-1 illuminating with a single interior optical fiber light source. Meanwhile, a higher H2 yield of 1.495 mol H2 mol-1 glucose and an average H2 production rate of 38.7ml l-1 h-1 were attained illuminating with a compound lamp in the continuous H2 production for 20 days.
[Mh] Termos MeSH primário: Biofilmes
Hidrogênio/metabolismo
Fotossíntese
Rodopseudomonas/metabolismo
[Mh] Termos MeSH secundário: Reatores Biológicos
Luz
Fatores de Tempo
[Pt] Tipo de publicação:RESEARCH SUPPORT, NON-U.S. GOV'T; JOURNAL ARTICLE
[Nm] Nome de substância:
7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  6 / 22155 MEDLINE  
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[PMID]:29221868
[Au] Autor:Zhu G; Gao X; Wang X; Wang J; Fan J
[Ad] Endereço:School of Environment, Henan Key Laboratory for Environmental Pollution Control, Key Laboratory for Yellow River and Huai River Water Environmental Pollution Control, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, PR China.
[Ti] Título:Influence of hydrogen bond accepting ability of anions on the adsorption performance of ionic liquid surface molecularly imprinted polymers.
[So] Source:J Chromatogr A;1532:40-49, 2018 Jan 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To illuminate the influence mechanism of anionic structure of ionic liquids (ILs) on the adsorption performance of surface molecularly imprinted polymers (MIPs), in this work, six newly designed MIPs were prepared on the surface of amino-poly(styrene-divinylbenzene) particles by using imidazolium ILs with the same cation [C mim] but different anions (Cl, CH SO , PF , BF , C F O , C F SO ) as template molecules, methacrylic acid as functional monomer, and ethylene dimethacrylate as cross-linker. The resulting MIP materials were characterized by IR and SEM, and the influence of hydrogen bond accepting ability of anions on the adsorption performance of the MIPs for the ILs was investigated in acetonitrile. It was found that adsorption capacity of the MIPs towards the ILs decreased in the order MIP > MIP ≥ MIP and MIP > MIP > MIP , which is in good agreement with the ability of anions of the ILs to form hydrogen bonds. Ultraviolet, H-NMR and Cl-NMR spectroscopy was then used to study the interactions of anions of the ILs with the functional monomer. It was found that the hydrogen bond interaction between anions of the ILs and acidic proton of the functional monomer was the main driving force for the high adsorption selectivity of the imprinted polymers, and the stronger hydrogen bond interaction indicates higher binding capacity and higher selectivity of the polymers towards the ILs. It was also verified that the ILs with stronger hydrogen bond accepting ability of anions could be selectively extracted by the corresponding IL-MIPs. These results may provide new insight into the recognition mechanism of MIPs for ILs, and are also useful for the rational design of this new class of imprinting materials.
[Mh] Termos MeSH primário: Ânions/química
Líquidos Iônicos/química
Impressão Molecular
Polímeros/química
[Mh] Termos MeSH secundário: Adsorção
Hidrogênio
Ligações de Hidrogênio
Metacrilatos/química
Espectroscopia de Prótons por Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Ionic Liquids); 0 (Methacrylates); 0 (Polymers); 1CS02G8656 (methacrylic acid); 7BK5G69305 (ethylene dimethacrylate); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


  7 / 22155 MEDLINE  
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[PMID]:29264600
[Au] Autor:Breglia R; Greco C; Fantucci P; De Gioia L; Bruschi M
[Ad] Endereço:Department of Earth and Environmental Science, University of Milano Bicocca, Piazza della Scienza 1, 20126 Milan, Italy. maurizio.bruschi@unimib.it.
[Ti] Título:Theoretical investigation of aerobic and anaerobic oxidative inactivation of the [NiFe]-hydrogenase active site.
[So] Source:Phys Chem Chem Phys;20(3):1693-1706, 2018 Jan 17.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The extraordinary capability of [NiFe]-hydrogenases to catalyse the reversible interconversion of protons and electrons into dihydrogen (H ) has stimulated numerous experimental and theoretical studies addressing the direct utilization of these enzymes in H production processes. Unfortunately, the introduction of these natural H -catalysts in biotechnological applications is limited by their inhibition under oxidising (aerobic and anaerobic) conditions. With the aim of contributing to overcome this limitation, we studied the oxidative inactivation mechanism of [NiFe]-hydrogenases by performing Density Functional Theory (DFT) calculations on a very large model of their active site in which all the amino acids forming the first and second coordination spheres of the NiFe cluster have been explicitly included. We identified an O molecule and two H O molecules as sources of the two oxygen atoms that are inserted at the active site of the inactive forms of the enzyme (Ni-A and Ni-B) under aerobic and anaerobic conditions, respectively. Furthermore, our results support the experimental evidence that the Ni-A-to-Ni-B ratio strongly depends on the number of reducing equivalents available for the process and on the oxidizing conditions under which the reaction takes place.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Hidrogenase/química
Modelos Moleculares
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
Biocatálise
Domínio Catalítico
Chromatiaceae/enzimologia
Hidrogênio/química
Hidrogenase/metabolismo
Oxirredução
Oxigênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 7YNJ3PO35Z (Hydrogen); EC 1.12.- (nickel-iron hydrogenase); EC 1.12.7.2 (Hydrogenase); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp06228a


  8 / 22155 MEDLINE  
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[PMID]:29198702
[Au] Autor:Wu D; Liang M; Dang H; Fang F; Xu F; Liu C
[Ad] Endereço:Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongq
[Ti] Título:Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway.
[So] Source:Biochem Biophys Res Commun;495(2):1620-1627, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxidative stress is regarded as a key regulator in the pathogenesis of prolonged hyperoxia-induced lung injury, which causes injury to alveolar epithelial cells and eventually leads to development of bronchopulmonary dysplasia (BPD). Many studies have shown that hydrogen has a protective effect in a variety of cells. However, the mechanisms by which hydrogen rescues cells from damage due to oxidative stress in BPD remains to be fully elucidated. This study sought to evaluate the effects of hydrogen on hyperoxia-induced lung injury and to investigate the underlying mechanism. Primary type II alveolar epithelial cells (AECIIs) were divided into four groups: control (21% oxygen), hyperoxia (95% oxygen), hyperoxia + hydrogen, and hyperoxia + hydrogen + LY294002 (a PI3K/Akt inhibitor). Proliferation and apoptosis of AECIIs were assessed using MTS assay and flow cytometry (FCM), respectively. Gene and protein expression were detected by quantitative polymerase chain reaction (q-PCR) and western blot analysis. Stimulation with hyperoxia decreased the expression of P-Akt, P- FoxO3a, cyclinD1 and Bcl-2. Hyperoxic conditions increased levels of Bim, Bax, and Foxo3a, which induced proliferation restriction and apoptosis of AECIIs. These effects of hyperoxia were reversed with hydrogen pretreatment. Furthermore, the protective effects of hydrogen were abrogated by PI3K/Akt inhibitor LY294002. The results indicate that hydrogen protects AECIIs from hyperoxia-induced apoptosis by inhibiting apoptosis factors and promoting the expression of anti-apoptosis factors. These effects were associated with activation of the PI3K/Akt/FoxO3a pathway.
[Mh] Termos MeSH primário: Células Epiteliais Alveolares/efeitos dos fármacos
Células Epiteliais Alveolares/metabolismo
Hidrogênio/farmacologia
Hiperóxia/tratamento farmacológico
Hiperóxia/metabolismo
[Mh] Termos MeSH secundário: Lesão Pulmonar Aguda/tratamento farmacológico
Lesão Pulmonar Aguda/metabolismo
Lesão Pulmonar Aguda/patologia
Células Epiteliais Alveolares/patologia
Animais
Apoptose/efeitos dos fármacos
Proteína 11 Semelhante a Bcl-2/genética
Células Cultivadas
Ciclina D1/genética
Feminino
Proteína Forkhead Box O3/genética
Proteína Forkhead Box O3/metabolismo
Expressão Gênica/efeitos dos fármacos
Genes bcl-2/efeitos dos fármacos
Hidrogênio/metabolismo
Hiperóxia/patologia
Estresse Oxidativo/efeitos dos fármacos
Fosfatidilinositol 3-Quinases/metabolismo
Gravidez
Proteínas Proto-Oncogênicas c-akt/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Sprague-Dawley
Transdução de Sinais/efeitos dos fármacos
Proteína X Associada a bcl-2/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bax protein, rat); 0 (Bcl-2-Like Protein 11); 0 (Bcl2l11 protein, rat); 0 (Ccnd1 protein, rat); 0 (Forkhead Box Protein O3); 0 (Foxo3a protein, rat); 0 (RNA, Messenger); 0 (bcl-2-Associated X Protein); 136601-57-5 (Cyclin D1); 7YNJ3PO35Z (Hydrogen); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  9 / 22155 MEDLINE  
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[PMID]:29406116
[Au] Autor:Nguyen TN; Chen PC; Huang C
[Ad] Endereço:Institute of Environmental Engineering, National Chiao Tung University, Hsinchu 300, Chinese Taipei.
[Ti] Título:Nitrate removal and extracellular polymeric substances of autohydrogenotrophic bacteria under various pH and hydrogen flow rates.
[So] Source:J Environ Sci (China);63:50-57, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In recent years there has been an increasing interest in the use of autohydrogenotrophic bacteria to treat nitrate from wastewater. However, our knowledge about the characteristics of extracellular polymeric substances (EPS) releasing by these activities is not yet very advanced. This study aimed to investigate the change in EPS compositions under various pH values and hydrogen flow rates, taking into consideration nitrogen removal. Results showed that pH7.5 and a hydrogen flow rate of 90mL/min were the optimal operating conditions, resulting in 100% nitrogen removal after 6hr of operation. Soluble and bound polysaccharides decreased, while bound proteins increased with increasing pH. Polysaccharides increased with increasing hydrogen flow rate. No significant change of bound proteins was observed at various hydrogen flow rates.
[Mh] Termos MeSH primário: Polissacarídeos Bacterianos/química
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
[Mh] Termos MeSH secundário: Bactérias
Hidrogênio/química
Concentração de Íons de Hidrogênio
Nitratos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Polysaccharides, Bacterial); 0 (Waste Water); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  10 / 22155 MEDLINE  
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[PMID]:29311508
[Au] Autor:Sawama Y; Park K; Yamada T; Sajiki H
[Ad] Endereço:Laboratory of Organic Chemistry, Gifu Pharmaceutical University.
[Ti] Título:New Gateways to the Platinum Group Metal-Catalyzed Direct Deuterium-Labeling Method Utilizing Hydrogen as a Catalyst Activator.
[So] Source:Chem Pharm Bull (Tokyo);66(1):21-28, 2018.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Deuterium-labeled compounds are widely utilized in various scientific fields. We summarize the recent advances in the direct deuteration of sugar, saturated fatty acid, and arene derivatives using heterogeneous platinum group metal on carbon catalysts by our research group. Hydrogen gas is a key catalyst-activator to facilitate the present H-D exchange reactions. In this review, the direct activation method of catalysts using in situ-generated hydrogen based on the dehydrogenation of alcohols is introduced. The obtained multiple deuterium-labeled products, including bioactive compounds, are expected to contribute to the development of many scientific investigations.
[Mh] Termos MeSH primário: Deutério/química
Hidrogênio/química
Metais Pesados/química
Compostos Organometálicos/química
[Mh] Termos MeSH secundário: Álcoois/química
Catálise
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alcohols); 0 (Metals, Heavy); 0 (Organometallic Compounds); 7YNJ3PO35Z (Hydrogen); AR09D82C7G (Deuterium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00222



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