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[PMID]:29236925
[Au] Autor:Magalhães LS; Bomfim LG; Mota SG; Cruz GS; Corrêa CB; Tanajura DM; Lipscomb MW; Borges VM; Jesus AR; Almeida RP; Moura TR
[Ad] Endereço:Laboratório de Biologia Molecular, Hospital Universitário, Universidade Federal de Sergipe, Aracaju, SE, Brasil.
[Ti] Título:Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil.
[So] Source:Mem Inst Oswaldo Cruz;113(2):119-125, 2018 Feb.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Treatment-refractory visceral leishmaniasis (VL) has become an important problem in many countries. OBJECTIVES We evaluated the antimony-resistance mechanisms of Leishmania infantum isolated from VL patients refractory or responsive to treatment with pentavalent antimony. METHODS Strains isolated from antimony-refractory patients (in vitro antimony-resistant isolates) and antimony-responsive patients (in vitro antimony-sensitive isolates) were examined. Morphological changes were evaluated by transmission electron microscopy after trivalent antimony exposure. P-glycoprotein (P-gp) efflux pump activity was evaluated using the pump-specific inhibitor verapamil hydrochloride, and the role of thiol in trivalent antimony resistance was investigated using the enzymatic inhibitor L-buthionine sulfoximine. FINDINGS Antimony treatment induced fewer alterations in the cellular structure of L. infantum resistant isolates than in that of sensitive isolates. P-gp efflux activity was not involved in antimony resistance in these isolates. Importantly, the resistant isolates contained higher levels of thiol compared to the sensitive isolates, and inhibition of thiol synthesis in the resistant isolates recovered their sensitivity to trivalent antimony treatment, and enhanced the production of reactive oxygen species in promastigotes exposed to the drug. MAIN CONCLUSIONS Our results demonstrate that isolates from patients with antimony-refractory VL exhibited higher thiol levels than antimony-sensitive isolates. This indicates that redox metabolism plays an important role in the antimony-resistance of New World VL isolates.
[Mh] Termos MeSH primário: Antimônio/farmacologia
Leishmania infantum/efeitos dos fármacos
Leishmania infantum/ultraestrutura
Leishmaniose Visceral/parasitologia
Compostos de Sulfidrila/metabolismo
[Mh] Termos MeSH secundário: Butionina Sulfoximina/farmacologia
Resistência a Medicamentos
Inibidores Enzimáticos/farmacologia
Seres Humanos
Microscopia Eletrônica de Transmissão
Testes de Sensibilidade Parasitária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Sulfhydryl Compounds); 5072-26-4 (Buthionine Sulfoximine); 9IT35J3UV3 (Antimony)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29206878
[Au] Autor:Fløtre CH; Varsi K; Helm T; Bolann B; Bjørke-Monsen AL
[Ad] Endereço:Faculty of Medicine, University of Bergen, Bergen, Norway.
[Ti] Título:Predictors of mercury, lead, cadmium and antimony status in Norwegian never-pregnant women of fertile age.
[So] Source:PLoS One;12(12):e0189169, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of toxic trace elements in never-pregnant women of fertile age is of concern. METHODS: Healthy, never-pregnant women aged 18 to 40 years (n = 158) were recruited between June 2012 and March 2015 in Bergen, Norway. Clinical data were collected and non-fasting venous blood samples were analyzed for whole blood Hg, Pb and Cd and serum Sb by ICP-MS and related to diet and life style factors. RESULTS: In a multiple linear regression model, increasing age was associated with higher levels of Hg and Sb, but diet and life style factors were more important predictors. Median whole blood Hg was increased by a factor of 70 in women who had fish for dinner ≥1/week, compared to women who rarely or never ate fish (p<0.001). Alcohol intake was the strongest predictor for whole blood Pb, while use of tobacco was the strongest predictor for whole blood Cd. Being a vegetarian was associated with lower levels of both Hg and Sb. CONCLUSIONS: As toxic trace elements tend to bioaccumulate in the body, increasing maternal age at delivery may represent a threat to the next generation. In a group of healthy Norwegian never-pregnant women, age contributed to Hg and Sb levels, but diet and life style factors were stronger determinants of whole blood Hg, Pb, Cd and serum Sb levels. Continuous public actions are needed to reduce modifiable and preventable sources of potentially deleterious toxins to minimize the exposure in children and fertile women.
[Mh] Termos MeSH primário: Antimônio/sangue
Cádmio/sangue
Chumbo/sangue
Mercúrio/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Estilo de Vida
Noruega
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
00BH33GNGH (Cadmium); 2P299V784P (Lead); 9IT35J3UV3 (Antimony); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189169


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[PMID]:28926630
[Au] Autor:Brito NC; Rabello A; Cota GF
[Ad] Endereço:Pesquisas Clínicas e Políticas Públicas em Doenças Infecto-Parasitárias-Centro de Pesquisas René Rachou-Fundação Oswaldo Cruz, Fiocruz, Belo Horizonte, Minas Gerais, Brazil.
[Ti] Título:Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: A systematic review.
[So] Source:PLoS One;12(9):e0184777, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The mainstays of cutaneous leishmaniasis (CL) treatment, in several world regions, are pentavalent antimony (Sbv) compounds administered parenterally, despite their recognized toxicity, which requires frequent laboratory monitoring and complicates their use in areas with scarce infrastructure. As result of these drawbacks, the WHO Expert Committee on leishmaniasis has expanded the recommendations for the use of local therapies, including Sbv intralesional infiltration (IL-Sbv), as CL therapy alternatives even in the New World. However, the efficacy of these approaches has never been compiled. The aim of this study was to critically and systematically assess the efficacy of IL-Sbv for CL treatment. METHODOLOGY: The PRISMA guidelines for systematic reviews and the Cochrane manual were followed. The sources used were the MEDLINE and LILACS databases and the International Clinical Trials Registry Platform of the World Health Organization. The outcome of interest was a clinical cure, defined as complete re-epithelialization of all lesions. The IL-Sbv pooled cure rate was estimated for several subgroups and direct comparisons were performed when possible. RESULTS: Thirty nine articles (40 studies) involving 5679 patients treated with IL-Sbv infiltration were included. In direct comparison, only three studies involving 229 patients compared IL-Sbv infiltration versus placebo and no difference was observed (OR: 1,9; 95%IC 0,93 to 3,82) based on cure rate 69.6% (95%CI 17.6-96.1%) and 83,2% (95%CI 66-92.7%) for placebo and IL-Sbv, respectively. In an alternative and non-comparative analysis, gathering all study arms using the intervention, the pooled IL-Sbv efficacy rate was 75% (95%CI 68-81%). In the Old World, the observed overall IL-Sbv efficacy rate was 75% (95%CI 66-82%), and the cure rates were significantly higher with sodium stibogluconate (SSG) than with meglumine antimoniate (MA): 83% (95%CI 75-90%) versus 68% (95%CI 54-79%), p = 0.03. Studies directly comparing IL-Sbv with topical 15% paromomycin ointment, IL hypertonic saline, radiofrequency-induced heat therapy, topical trichloroacetic acid and cryotherapy showed no significant difference in efficacy between the interventions. The analyses suggested a higher efficacy of IL-Sbv combined with cryotherapy (81.8%, 95%IC 62.4-92.4%) when compared with IL-Sbv alone (53.3%, 95%IC 46.1-66%), OR: 3.14 (95%CI 1.1-8.9), p = 0.03. In the New World, the global IL-Sbv efficacy was 77%(95%CI 66-85%). In contrast with the Old World, a significant difference favoring MA in relation to SSG was observed: 61% (95%CI 49-73%) versus 82% (95%CI 70-89%).By comparing IL infiltration schedules, it was determined that patients submitted to IL-Sbv treatments longer than 14 days had higher cure rates. CONCLUSIONS: Despite the high heterogeneity and low methodological quality of studies, an indirect comparison shows that the antimony infiltration efficacy rate is similar to that reported for antimony systemic use. The evidence gathered thus far is insufficient to identify the ideal IL therapeutic regime or estimate the rates of adverse events and mucosal late complications.
[Mh] Termos MeSH primário: Antimônio/uso terapêutico
Antiprotozoários/uso terapêutico
Leishmaniose Cutânea/tratamento farmacológico
[Mh] Termos MeSH secundário: Antimônio/química
Gluconato de Antimônio e Sódio/uso terapêutico
Antiprotozoários/química
Crioterapia
Bases de Dados Factuais
Seres Humanos
Injeções Intralesionais
Leishmaniose Cutânea/patologia
Meglumina/uso terapêutico
Compostos Organometálicos/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Organometallic Compounds); 6HG8UB2MUY (Meglumine); 75G4TW236W (meglumine antimoniate); 9IT35J3UV3 (Antimony); V083S0159D (Antimony Sodium Gluconate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184777


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[PMID]:28873463
[Au] Autor:Ortega A; Garrido I; Casimiro I; Espinosa F
[Ad] Endereço:FBCMP Research Group, University of Extremadura, Campus Avenida Elvas, Badajoz, Spain.
[Ti] Título:Effects of antimony on redox activities and antioxidant defence systems in sunflower (Helianthus annuus L.) plants.
[So] Source:PLoS One;12(9):e0183991, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The alterations induced by the toxicity of antimony (Sb) in the roots and leaves of sunflower plants were determined. The plants were grown hydroponically with different concentrations of Sb, a heavy metal which reduces biomass production and growth. There was preferential accumulation of Sb in the tissues of the roots, with the concentrations in the leaves being much lower. The accumulation of other mineral elements was also altered, especially that of Fe and Zn. Chlorophyll content declined, as also did the photosynthetic efficiency, but the carotenoid content remained unaltered. The total content of phenolics, flavonoids, and phenylpropanoid glycosides rose, evidence of their participation in the defence response. Increases were observed in the amount of superoxide anion in both roots and leaves, and in lipid peroxidation levels, especially with the highest Sb concentration of 1.0 mM. The induced oxidative stress leads to a strong increase in the SOD, POX and APX antioxidant activities, while the GR activity was only increased in the leaves and at the 1.0 mM Sb concentration. In contrast, the DHAR activity increased considerably in both organs. The GSNOR activity increased only in roots, and the total RSNOs increased. The total amount of AsA + DHA increased in roots and remained unaltered in leaves, whereas that of GSH + GSSG decreased considerably in all cases. As a whole, these results are evidence for the development of a strong oxidative stress induced by Sb, with there being a clear imbalance in the content of the compounds that constitute the AsA/GSH cycle. 0.5 mM Sb enhances GST expression, especially in leaves. This, together with the increase that was observed in the amount of GSH, may play an important part in detoxification. This oxidative stress affects both the phenolic and the ROS/RNS metabolic processes, which seems to implicate their involvement in the plant's defence and response to the stress.
[Mh] Termos MeSH primário: Antimônio/química
Antioxidantes/química
Helianthus/enzimologia
Oxirredução
[Mh] Termos MeSH secundário: Ácido Ascórbico/química
Biomassa
Carotenoides/química
Clorofila/química
Glutationa/metabolismo
Helianthus/efeitos dos fármacos
Peróxido de Hidrogênio/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Oxidantes/química
Estresse Oxidativo/efeitos dos fármacos
Oxigênio/química
Fenol/química
Fotossíntese
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
RNA Mensageiro/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Plântulas/metabolismo
Sementes/metabolismo
Superóxido Dismutase/metabolismo
Superóxidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oxidants); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 11062-77-4 (Superoxides); 1406-65-1 (Chlorophyll); 339NCG44TV (Phenol); 36-88-4 (Carotenoids); 4Y8F71G49Q (Malondialdehyde); 9IT35J3UV3 (Antimony); BBX060AN9V (Hydrogen Peroxide); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); PQ6CK8PD0R (Ascorbic Acid); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183991


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[PMID]:28838766
[Au] Autor:Tonelli M; Wiebe N; Bello A; Field CJ; Gill JS; Hemmelgarn BR; Holmes DT; Jindal K; Klarenbach SW; Manns BJ; Thadhani R; Kinniburgh D; Alberta Kidney Disease Network
[Ad] Endereço:Department of Medicine, University of Calgary, Calgary, Canada. Electronic address: tonelli.admin@ucalgary.ca.
[Ti] Título:Concentrations of Trace Elements in Hemodialysis Patients: A Prospective Cohort Study.
[So] Source:Am J Kidney Dis;70(5):696-704, 2017 Nov.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Low concentrations and excessive concentrations of trace elements have been commonly reported in hemodialysis patients, but available studies have several important limitations. STUDY DESIGN: Random sample of patients drawn from a prospective cohort. SETTING & PARTICIPANTS: 198 incident hemodialysis patients treated in 3 Canadian centers. MEASUREMENTS: We used mass spectrometry to measure plasma concentrations of the 25 elements at baseline, 6 months, 1 year, and 2 years following enrollment in the cohort. We focused on low concentrations of zinc, selenium, and manganese and excessive concentrations of lead, arsenic, and mercury; low and excessive concentrations of the other 19 trace elements were treated as exploratory analyses. Low and excessive concentrations were based on the 5th and 95th percentile plasma concentrations from healthy reference populations. RESULTS: At all 4 occasions, low zinc, selenium, and manganese concentrations were uncommon in study participants (≤5.1%, ≤1.8%, and ≤0.9% for zinc, selenium, and manganese, respectively) and a substantial proportion of participants had concentrations that exceeded the 95th percentile (≥65.2%, ≥74.2%, and ≥19.7%, respectively). Almost all participants had plasma lead concentrations above the 95th percentile at all time points. The proportion of participants with plasma arsenic concentrations exceeding the 95th percentile was relatively constant over time (9.1%-9.8%); the proportion with plasma mercury concentrations that exceeded the 95th percentile varied between 15.2% and 29.3%. Low arsenic, platinum, tungsten, and beryllium concentrations were common (>50%), as were excessive cobalt, manganese, zinc, vanadium, cadmium, selenium, barium, antimony, nickel, molybdenum, lead, and chromium concentrations. CONCLUSIONS: There was no evidence that low zinc, selenium, or manganese concentrations exist in most contemporary Canadian hemodialysis patients. Some patients have excessive plasma arsenic and mercury concentrations, and excessive lead concentrations were common. These findings require further investigation.
[Mh] Termos MeSH primário: Falência Renal Crônica/sangue
Oligoelementos/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antimônio/sangue
Arsênico/sangue
Bário/sangue
Berílio/sangue
Cádmio/sangue
Cromo/sangue
Cobalto/sangue
Estudos de Coortes
Feminino
Seres Humanos
Falência Renal Crônica/terapia
Chumbo/sangue
Masculino
Manganês/sangue
Espectrometria de Massas
Mercúrio/sangue
Meia-Idade
Molibdênio/sangue
Níquel/sangue
Platina/sangue
Estudos Prospectivos
Diálise Renal
Selênio/sangue
Tungstênio/sangue
Vanádio/sangue
Adulto Jovem
Zinco/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trace Elements); 00BH33GNGH (Cadmium); 00J9J9XKDE (Vanadium); 0R0008Q3JB (Chromium); 24GP945V5T (Barium); 2P299V784P (Lead); 3G0H8C9362 (Cobalt); 42Z2K6ZL8P (Manganese); 49DFR088MY (Platinum); 7OV03QG267 (Nickel); 81AH48963U (Molybdenum); 9IT35J3UV3 (Antimony); FXS1BY2PGL (Mercury); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc); N712M78A8G (Arsenic); OW5102UV6N (Beryllium); V9306CXO6G (Tungsten)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


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[PMID]:28764084
[Au] Autor:Biata NR; Nyaba L; Ramontja J; Mketo N; Nomngongo PN
[Ad] Endereço:Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Johannesburg 2028, South Africa.
[Ti] Título:Determination of antimony and tin in beverages using inductively coupled plasma-optical emission spectrometry after ultrasound-assisted ionic liquid dispersive liquid-liquid phase microextraction.
[So] Source:Food Chem;237:904-911, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to develop a simple and fast ultrasound-assisted ionic liquid dispersive liquid-liquid phase microextraction (UA-IL-DLLME) method for preconcetration of trace antimony and tin in beverage samples. The novelty of this study was based on the application of ligandless UA-IL-DLLME using low-density ionic liquid and organic solvents for preconcentration of Sb and Sn. The concentration of Sb and Sn were quantified using ICP-OES. Under the optimum conditions, the calibration graph was found to be LOQ-250µgL (r =0.9987) for Sb and LOQ-350µgL for Sn. The LOD and LOQ of Sb and Sn ranged from 1.2to 2.5ngL and 4.0 to 8.3ngL , respectively, with high preconcentration factors. The precisions (%RSD) of the proposed method ranged from 2.1% to 2.5% and 3.9% to 4.7% for Sb and Sn, respectively. The proposed method was successfully applied for determination of Sb and Sn in beverages.
[Mh] Termos MeSH primário: Bebidas/análise
[Mh] Termos MeSH secundário: Antimônio
Líquidos Iônicos
Microextração em Fase Líquida
Análise Espectral
Estanho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ionic Liquids); 7440-31-5 (Tin); 9IT35J3UV3 (Antimony)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28700218
[Au] Autor:Sun W; Xiao E; Xiao T; Krumins V; Wang Q; Häggblom M; Dong Y; Tang S; Hu M; Li B; Xia B; Liu W
[Ad] Endereço:Guangdong Key Laboratory of Agricultural Environment Pollution Integrated Control, Guangdong Institute of Eco-Environmental Science & Technology , Guangzhou 510650, China.
[Ti] Título:Response of Soil Microbial Communities to Elevated Antimony and Arsenic Contamination Indicates the Relationship between the Innate Microbiota and Contaminant Fractions.
[So] Source:Environ Sci Technol;51(16):9165-9175, 2017 Aug 15.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mining of sulfide ore deposits containing metalloids, such as antimony and arsenic, has introduced serious soil contamination around the world, posing severe threats to food safety and human health. Hence, it is important to understand the behavior and composition of the microbial communities that control the mobilization or sequestration of these metal(loid)s. Here, we selected two sites in Southwest China with different levels of Sb and As contamination to study interactions among various Sb and As fractions and the soil microbiota, with a focus on the microbial response to metalloid contamination. Comprehensive geochemical analyses and 16S rRNA gene amplicon sequencing demonstrated distinct soil taxonomic inventories depending on Sb and As contamination levels. Stochastic gradient boosting indicated that citric acid extractable Sb(V) and As(V) contributed 5% and 15%, respectively, to influencing the community diversity. Random forest predicted that low concentrations of Sb(V) and As(V) could enhance the community diversity but generally, the Sb and As contamination impairs microbial diversity. Co-occurrence network analysis indicated a strong correlation between the indigenous microbial communities and various Sb and As fractions. A number of taxa were identified as core genera due to their elevated abundances and positive correlation with contaminant fractions (total Sb and As concentrations, bioavailable Sb and As extractable fractions, and Sb and As redox species). Shotgun metagenomics indicated that Sb and As biogeochemical redox reactions may exist in contaminated soils. All these observations suggest the potential for bioremediation of Sb- and As-contaminated soils.
[Mh] Termos MeSH primário: Antimônio
Arsênico
Microbiologia do Solo
Poluentes do Solo
[Mh] Termos MeSH secundário: China
Monitoramento Ambiental
Seres Humanos
Microbiota
RNA Ribossômico 16S
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S); 0 (Soil); 0 (Soil Pollutants); 9IT35J3UV3 (Antimony); N712M78A8G (Arsenic)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b00294


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[PMID]:28690308
[Au] Autor:Shiozawa Y; Haneishi N; Suzuki K; Ogimoto M; Takanashi M; Tomioka N; Uematsu Y; Monma K
[Ad] Endereço:Tokyo Metropolitan Institute of Public Health.
[Ti] Título:Survey on Metals Contained in Stainless Steel Kitchenware and Tableware.
[So] Source:Shokuhin Eiseigaku Zasshi;58(3):166-171, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Stainless steel kitchenware and tableware on sale in Japan were investigated. Surface elemental composition ratios of 172 samples were analyzed by the fluorescence X-ray method. High levels of manganese (9.59-20.03%)were detected in 17 samples. This finding was confirmed by ICP analysis. Next, we conducted migration tests. Samples conformed to the Italian Specific Migration Limits. Moreover, lead and antimony were not detected in these samples, in accordance with the Japanese Food Sanitation Law.
[Mh] Termos MeSH primário: Utensílios de Alimentação e Culinária
Legislação sobre Alimentos/normas
Manganês/análise
Aço Inoxidável/química
[Mh] Termos MeSH secundário: Antimônio/análise
Cádmio/análise
Cromo/análise
Ferro/análise
Japão
Chumbo/análise
Níquel/análise
Espectrometria por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
00BH33GNGH (Cadmium); 0R0008Q3JB (Chromium); 12597-68-1 (Stainless Steel); 2P299V784P (Lead); 42Z2K6ZL8P (Manganese); 7OV03QG267 (Nickel); 9IT35J3UV3 (Antimony); E1UOL152H7 (Iron)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.166


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[PMID]:28662149
[Au] Autor:Nunes DCO; Bispo-da-Silva LB; Napolitano DR; Costa MS; Figueira MMNR; Rodrigues RS; Rodrigues VM; Yoneyama KAG
[Ad] Endereço:Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
[Ti] Título:In vitro additive interaction between ketoconazole and antimony against intramacrophage Leishmania (Leishmania) amazonensis amastigotes.
[So] Source:PLoS One;12(6):e0180530, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmaniasis is a group of diseases caused by protozoa of Leishmania genus. The currently available treatments for this disease are expensive, present high toxicity and are associated to difficulties of healing and parasite resistance. Therefore, the development of strategies for leishmaniasis treatment is indispensable and includes reposition of existing drugs, as well as drug combination therapy. The aim of this study was to assess the nature of ketoconazole and antimony association on the cytotoxic effect against Leishmania (Leishmania) amazonensis amastigotes. The calculated mean sum of fractional 50% inhibitory concentration ([Formula: see text]ΣFIC50) was 2.54 and 1.43 for free and intracellular amastigotes, respectively, values that suggest an additive interaction between ketoconazole and antimony concerning to Leishmania toxicity only in the intramacrophage parasite form. Despite the clinical efficacy of ketoconazole-antimony combination has been shown in the literature, our study is the first to describe the nature of ketoconazole-antimony interaction against L. (L.) amazonensis amastigotes. Moreover, our results point out the need for future in vivo studies to confirm the nature of ketoconazole-antimony interaction and also to determine possible effective dosage regimens related to ketoconazole administration in association with the optimal lower dose of antimony.
[Mh] Termos MeSH primário: Antimônio/farmacologia
Cetoconazol/farmacologia
Leishmania/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimônio/administração & dosagem
Sinergismo Farmacológico
Feminino
Técnicas In Vitro
Cetoconazol/administração & dosagem
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9IT35J3UV3 (Antimony); R9400W927I (Ketoconazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180530


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[PMID]:28659356
[Au] Autor:Chakraborty A; Kurati SP; Mahata SK; Sundar S; Roy S; Sen M
[Ad] Endereço:Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India.
[Ti] Título:Wnt5a Signaling Promotes Host Defense against Infection.
[So] Source:J Immunol;199(3):992-1002, 2017 Aug 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:infects macrophages, disrupting immune homeostasis. The underlying mechanism that sustains infection remains unresolved. In view of the potential of Wnt5a signaling to support immune homeostasis, we evaluated the interrelationship of Wnt5a signaling and infection. Upon infecting macrophages separately with antimony drug-sensitive and -resistant , we noted disruption in the steady-state level of Wnt5a. Moreover, inhibition of Wnt5a signaling by small interfering RNA transfection in vitro or by use of inhibitor of Wnt production in vivo led to an increase in cellular parasite load. In contrast, treatment of macrophages with recombinant Wnt5a caused a decrease in the load of antimony-sensitive and -resistant parasites, thus confirming that Wnt5a signaling antagonizes infection. Using inhibitors of the Wnt5a signaling intermediates Rac1 and Rho kinase, we demonstrated that Wnt5a-mediated inhibition of parasite infection in macrophages is Rac1/Rho dependent. Furthermore, phalloidin staining and reactive oxygen species estimation of Wnt5a-treated macrophages suggested that a Wnt5a-Rac/Rho-mediated decrease in parasite load is associated with an increase in F- actin assembly and NADPH oxidase activity. Moreover, live microscopy of -infected macrophages treated with Wnt5a demonstrated increased endosomal/lysosomal fusions with parasite-containing vacuoles (parasitophorous vacuoles [PV]). An increase in PV-endosomal/lysosomal fusion accompanied by augmented PV degradation in Wnt5a-treated macrophages was also apparent from transmission electron microscopy of infected cells. Our results suggest that, although evades host immune response, at least in part through inhibition of Wnt5a signaling, revamping Wnt5a signaling can inhibit infection, irrespective of drug sensitivity or resistance.
[Mh] Termos MeSH primário: Leishmania donovani/imunologia
Macrófagos/imunologia
Macrófagos/parasitologia
Proteína Wnt-5a/metabolismo
[Mh] Termos MeSH secundário: Actinas/metabolismo
Animais
Antimônio/farmacologia
Antiprotozoários/farmacologia
Leishmania donovani/efeitos dos fármacos
Leishmania donovani/fisiologia
Leishmaniose Visceral/imunologia
Macrófagos/ultraestrutura
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica de Transmissão
NADPH Oxidases/metabolismo
Neuropeptídeos/metabolismo
Carga Parasitária
Faloidina/química
RNA Interferente Pequeno/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais
Transfecção
Vacúolos/imunologia
Vacúolos/parasitologia
Proteína Wnt-5a/genética
Proteína Wnt-5a/farmacologia
Proteínas rac1 de Ligação ao GTP/metabolismo
Quinases Associadas a rho/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Antiprotozoal Agents); 0 (Neuropeptides); 0 (RNA, Small Interfering); 0 (Rac1 protein, mouse); 0 (Reactive Oxygen Species); 0 (Wnt-5a Protein); 0 (Wnt5a protein, mouse); 17466-45-4 (Phalloidine); 9IT35J3UV3 (Antimony); EC 1.6.3.- (NADPH Oxidases); EC 2.7.11.1 (rho-Associated Kinases); EC 3.6.5.2 (rac1 GTP-Binding Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601927



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