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[PMID]:28841529
[Au] Autor:Ghelichpour M; Taheri Mirghaed A; Mirzargar SS; Joshaghani H; Ebrahimzadeh Mousavi H
[Ad] Endereço:Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
[Ti] Título:Modification of saltwater stress response in Cyprinus carpio (Linnaeus, 1758) pre-exposed to pesticide indoxacarb.
[So] Source:Ecotoxicol Environ Saf;147:139-143, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To evaluate the effects of indoxacarb on saltwater stress response in Cyprinus carpio, the fish were pre-exposed to indoxacarb (0, 0.75, 1.5 and 3mg/L denoted as CP, 0.75IT, 1.5IT and 3IT, respectively) for 21 days and then released to saltwater. A negative control (CN) group was included (the fish were held in indoxacarb-free water for the entire experiment). The fish were sampled immediately (0h) and 24, 48 and 72h after the salinity exposure for the analysis of plasma cortisol, glucose and sodium, chloride, potassium and calcium levels. All fish pre-exposed to 3mg/L indoxacarb, died after the first day of salinity challenge. CP showed typical cortisol response after the salinity challenge, but, cortisol response of the fish pre-exposed to indoxacarb (0.75IT and 1.5IT) was blocked. Plasma glucose increased significantly in all groups compared to the CN; however, this elevation had no consistent trend in 0.75IT and 1.5IT which indicated interference in glucose response due to indoxacarb exposure. Plasma sodium increased (compared to CN) in all groups after the salinity challenge. However, elevation in plasma chloride and potassium was significantly different among the groups and the indoxacarb-treated fish showed slightly sooner ionic disturbance. The results clearly indicate that indoxacarb impairs stress response of C. carpio and the fish may not be able to respond normally to additional stressors, which threatens their survival.
[Mh] Termos MeSH primário: Carpas/metabolismo
Hidrocortisona/sangue
Osmorregulação/efeitos dos fármacos
Oxazinas/toxicidade
Praguicidas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Carpas/sangue
Cloretos/sangue
Relação Dose-Resposta a Droga
Potássio/sangue
Salinidade
Sódio/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Oxazines); 0 (Pesticides); 0 (Water Pollutants, Chemical); 52H0D26MWR (indoxacarb); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


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[PMID]:29427588
[Au] Autor:Nishimura-Danjobara Y; Oyama K; Yokoigawa K; Oyama Y
[Ad] Endereço:Department of Food Science, Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima 770-8513, Japan.
[Ti] Título:Hyperpolarization by N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, in rat thymic lymphocytes.
[So] Source:Chem Biol Interact;283:91-96, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:To study the adverse effects of N-(3-oxododecanoyl)-l-homoserine-lactone (ODHL), a quorum sensing molecule, on mammalian host cells, its effect on membrane potential was examined in rat thymic lymphocytes using flow cytometric techniques with a voltage-sensitive fluorescent probe. As 3-300 µM ODHL elicited hyperpolarization, it is likely that it increases membrane K permeability because hyperpolarization is directly linked to changing K gradient across membranes, but not Na and Cl gradients. ODHL did not increase intracellular Ca concentration. ODHL also produced a response in the presence of an intracellular Zn chelator. Thus, it is unlikely that intracellular Ca and Zn are attributed to the response. Quinine, a non-specific K channel blocker, greatly reduced hyperpolarization. However, because charybdotoxin, tetraethylammonium chloride, 4-aminopyridine, and glibenclamide did not affect it, it is pharmacologically hypothesized that Ca -activated K channels, voltage-gated K channels, and ATP-sensitive K channels are not involved in ODHL-induced hyperpolarization. Although the K channels responsible for ODHL-induced hyperpolarization have not been identified, it is suggested that ODHL can elicit hyperpolarization in mammalian host cells, disturbing cellular functions.
[Mh] Termos MeSH primário: 4-Butirolactona/análogos & derivados
Polaridade Celular/efeitos dos fármacos
Homosserina/análogos & derivados
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: 4-Butirolactona/farmacologia
Animais
Cálcio/metabolismo
Charibdotoxina/farmacologia
Citometria de Fluxo
Glibureto/farmacologia
Homosserina/farmacologia
Canais KATP/metabolismo
Linfócitos/citologia
Linfócitos/efeitos dos fármacos
Linfócitos/metabolismo
Permeabilidade/efeitos dos fármacos
Potássio/metabolismo
Canais de Potássio de Abertura Dependente da Tensão da Membrana/metabolismo
Quinina/farmacologia
Ratos
Ratos Wistar
Timócitos/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KATP Channels); 0 (N-(3-oxododecanoyl)homoserine lactone); 0 (Potassium Channels, Voltage-Gated); 115422-61-2 (Charybdotoxin); 6KA95X0IVO (Homoserine); A7V27PHC7A (Quinine); OL659KIY4X (4-Butyrolactone); RWP5GA015D (Potassium); SX6K58TVWC (Glyburide); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180211
[St] Status:MEDLINE


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[PMID]:29360848
[Au] Autor:Liu Z; Zhu J; Yang X; Wu H; Wei Q; Wei H; Zhang H
[Ad] Endereço:Research Center of Saline and Alkali Land of State Forestry Administration, Chinese Academy of Forestry, Beijing, P. R. China.
[Ti] Título:Growth performance, organ-level ionic relations and organic osmoregulation of Elaeagnus angustifolia in response to salt stress.
[So] Source:PLoS One;13(1):e0191552, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Elaeagnus angustifolia is one of the most extensively afforested tree species in environment-harsh regions of northern China. Despite its exceptional tolerance to saline soil, the intrinsic adaptive physiology has not been revealed. In this study, we investigated the growth, organ-level ionic relations and organic osmoregulation of the seedlings hydroponically treated with 0, 100 and 200 mM NaCl for 30 days. We found that the growth characteristics and the whole-plant dry weight were not obviously stunted, but instead, were even slightly stimulated by the treatment of 100 mM NaCl. In contrast, these traits were significantly inhibited by 200 mM NaCl treatment. Interestingly, as compared with the control (0 mM NaCl), both 100 and 200 mM NaCl treatments had a promotional effect on root growth as evidenced by 26.3% and 2.4% increases in root dry weight, respectively. Roots had the highest Na+ and Cl- concentrations and obviously served as the sink for the net increased Na+ and Cl-, while, stems might maintain the capacity of effective Na+ constraint, resulting in reduced Na+ transport to the leaves. K+, Ca2+ and Mg2+ concentrations in three plant organs of NaCl-treated seedlings presented a substantial decline, eventually leading to an enormously drop of K+/Na+ ratio. As the salt concentration increased, proline and soluble protein contents continuously exhibited a prominent and a relatively tardy accumulation, respectively, whereas soluble sugar firstly fell to a significant level and then regained to a level that is close to that of the control. Taken together, our results provided quantitative measures that revealed some robust adaptive physiological mechanisms underpinning E. angustifolia's moderately high salt tolerance, and those mechanisms comprise scalable capacity for root Na+ and Cl- storage, effectively constrained transportation of Na+ from stems to leaves, root compensatory growth, as well as an immediate and prominent leaf proline accumulation.
[Mh] Termos MeSH primário: Elaeagnaceae/efeitos dos fármacos
Osmorregulação
Cloreto de Sódio/farmacologia
Estresse Fisiológico
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Cloretos/metabolismo
Elaeagnaceae/crescimento & desenvolvimento
Elaeagnaceae/fisiologia
Transporte de Íons
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Potássio/metabolismo
Plântulas/metabolismo
Sódio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 451W47IQ8X (Sodium Chloride); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191552


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[PMID]:29173354
[Au] Autor:Feldman M; Dickson B
[Ad] Endereço:Department of Internal Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas. Electronic address: MarkFeldman@TexasHealth.org.
[Ti] Título:Plasma Electrolyte Distributions in Humans-Normal or Skewed?
[So] Source:Am J Med Sci;354(5):453-457, 2017 11.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is widely believed that plasma electrolyte levels are normally distributed. Statistical tests and calculations using plasma electrolyte data are often reported based on this assumption of normality. Examples include t tests, analysis of variance, correlations and confidence intervals. The purpose of our study was to determine whether plasma sodium (Na ), potassium (K ), chloride (Cl ) and bicarbonate [Formula: see text] distributions are indeed normally distributed. METHODS: We analyzed plasma electrolyte data from 237 consecutive adults (137 women and 100 men) who had normal results on a standard basic metabolic panel which included plasma electrolyte measurements. The skewness of each distribution (as a measure of its asymmetry) was compared to the zero skewness of a normal (Gaussian) distribution. RESULTS: The plasma Na distribution was skewed slightly to the right, but the skew was not significantly different from zero skew. The plasma Cl distribution was skewed slightly to the left, but again the skew was not significantly different from zero skew. On the contrary, both the plasma K and [Formula: see text] distributions were significantly skewed to the right (P < 0.01 zero skew). There was also a suggestion from examining frequency distribution curves that K and [Formula: see text] distributions were bimodal. CONCLUSIONS: In adults with a normal basic metabolic panel, plasma potassium and bicarbonate levels are not normally distributed and may be bimodal. Thus, statistical methods to evaluate these 2 plasma electrolytes should be nonparametric tests and not parametric ones that require a normal distribution.
[Mh] Termos MeSH primário: Eletrólitos/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Bicarbonatos/sangue
Cloretos/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Potássio/sangue
Sódio/sangue
Distribuições Estatísticas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Chlorides); 0 (Electrolytes); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28456777
[Au] Autor:Deska P; Nowicki M
[Ad] Endereço:Department of Internal Medicine District Hospital, Klobuck, Poland.
[Ti] Título:Short-term changes of serum potassium concentration induced by physical exercise in patient with arterial hypertension treated with angiotensin-converting enzyme inhibitor alone or in combination with statin.
[So] Source:J Physiol Pharmacol;68(1):133-138, 2017 Feb.
[Is] ISSN:1899-1505
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Intensive physical exercise may facilitate potassium release from skeletal muscles that may result in hyperkalemia. Commonly used drugs including angiotensin converting enzyme inhibitors (ACEI) and statins increase a risk of hyperkalemia. It is not known whether the effect of these drugs on serum potassium during physical exercise is additive. The study compared the effect of physical exercise on the changes of serum potassium in hypertensive patients receiving ACEI alone or in combination with statin. Eighteen patients with arterial hypertension with normal renal function were included in a prospective placebo-controlled cross-over study. The patients underwent 3 exercise tests on a bicycle ergometer with 55 - 60% of maximum oxygen consumption each lasting 30 minutes, i.e. after being treated with ACEI alone for six months, and then in a random order after the administration of ACEI with statin or ACEI with placebo each time for eight weeks separated by 2-week wash-out. Serum potassium was measured with atomic emission flame spectrometry before and after 15 and 30 minutes exercise and after 30-minute recovery. During the exercise serum potassium concentration increased moderately but significantly during all exercise tests. Mean serum potassium during exercise remained within the normal range. There were no differences in the exercise-induced changes of serum potassium during the exercise tests performed after ACEI combined with statin or with placebo. Addition of statin to ACEI does not increase the risk of hyperkalemia in hypertensive patients with preserved renal function during physical exercise with intensity typical for routine daily activities.
[Mh] Termos MeSH primário: Inibidores da Enzima Conversora de Angiotensina/farmacologia
Exercício/fisiologia
Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia
Hipertensão/sangue
Potássio/sangue
Ramipril/farmacologia
Sinvastatina/farmacologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Estudos Cross-Over
Quimioterapia Combinada
Teste de Esforço
Feminino
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
Hipertensão/tratamento farmacológico
Hipertensão/urina
Masculino
Meia-Idade
Potássio/urina
Ramipril/uso terapêutico
Sinvastatina/uso terapêutico
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); AGG2FN16EV (Simvastatin); L35JN3I7SJ (Ramipril); RWP5GA015D (Potassium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:27777016
[Au] Autor:Zhang Y; Loughery JR; Martyniuk CJ; Kieffer JD
[Ad] Endereço:Department of Biological Sciences, University of New Brunswick, Saint John, New Brunswick, Canada; Department of Biological Science, University of Alberta, Edmonton, AB, Canada.
[Ti] Título:Physiological and molecular responses of juvenile shortnose sturgeon (Acipenser brevirostrum) to thermal stress.
[So] Source:Comp Biochem Physiol A Mol Integr Physiol;203:314-321, 2017 01.
[Is] ISSN:1531-4332
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The shortnose sturgeon (Acipenser brevirostrum LeSueur, 1818) is a vulnerable species that is found along the eastern coast of North America. Little is known about temperature tolerance in this species and with a rapidly changing global climate, it becomes increasingly important to define the thermal tolerance of this species to better predict population distribution. Using a modified critical thermal maximum test (CTMax), the objectives of this study were to determine the impact of heating rate (0.1, 0.2 and 0.25°Cmin ) on the thermal tolerance, associated hematological responses, and oxygen consumption in juvenile sturgeon. In addition, transcripts associated with physiological stress and heat shock (i.e., heat shock proteins) were also measured. Heating rate did not alter the CTMax values of shortnose sturgeon. Neither heating rate nor thermal stress affected plasma sodium and chloride levels, nor the expression of transcripts that included catalase, glucocorticoid receptor, heat shock protein70 (hsp70), heat shock protein 90α (hsp90α) and cytochrome P450 1a (cyp1a). However, regardless of heating rate, thermal stress increased both plasma potassium and lactate concentrations. Glucose levels were increased at heating rates of 0.2 and 0.25°Cmin , but not at 0.1°Cmin . Overall, oxygen consumption rates increased with thermal stress, but the response patterns were not affected by heating rate. These data support the hypothesis that shortnose sturgeon can tolerate acute heat stress, as many physiological and molecular parameters measured here were non-responsive to the thermal stress.
[Mh] Termos MeSH primário: Glicemia/análise
Peixes/fisiologia
Ácido Láctico/sangue
Potássio/sangue
Estresse Fisiológico
Termotolerância
Regulação para Cima
[Mh] Termos MeSH secundário: Algoritmos
Animais
Aquicultura
Proteínas de Peixes/genética
Proteínas de Peixes/metabolismo
Peixes/sangue
Peixes/crescimento & desenvolvimento
Regulação da Expressão Gênica no Desenvolvimento
Aquecimento Global
Cinética
Novo Brunswick
Consumo de Oxigênio
Distribuição Aleatória
Rios
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Fish Proteins); 33X04XA5AT (Lactic Acid); RWP5GA015D (Potassium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:28451667
[Au] Autor:Chen Q; Svenum IH; Qi Y; Gavrilovic L; Chen; Holmen A; Blekkan EA
[Ad] Endereço:Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway. edd.a.blekkan@ntnu.no.
[Ti] Título:Potassium adsorption behavior on hcp cobalt as model systems for the Fischer-Tropsch synthesis: a density functional theory study.
[So] Source:Phys Chem Chem Phys;19(19):12246-12254, 2017 May 17.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Potassium (K), an important impurity in syngas from biomass, can have a large influence on the activity and selectivity of cobalt-based Fischer-Tropsch synthesis (FTS) catalysts in Biomass to Liquids (BTL) processes. In this work, the potassium adsorption behavior on hcp cobalt was systematically studied using density functional theory. The surface energy calculations and Wulff construction of the equilibrium shape of hcp cobalt showed it is dominated by 10 facets. The interaction of K with these facets has been investigated. The results showed that the stepped facet (10-12) has the highest K adsorption energy of -2.40 eV. The facets (0001), (10-10), (10-11), (10-15), and (21-30) also showed relatively high K adsorption energies in the range of -2.28 to -2.34 eV. The corrugated facets exhibited comparatively lower K adsorption energies (-2.04 to -2.18 eV), and would be less favorable for K adsorption. It was also found that the adsorption properties depend on coverage, where the K adsorption energy decreased with increasing coverage. Diffusion energy barrier calculations indicated that K was mobile on typical facets (0001) and (10-11) with very low diffusion barriers (<0.15 eV). On stepped facets, although K could move freely along the same step (diffusion barrier <0.01 eV), diffusion from one step to another had a significantly higher barrier of 0.56 eV. This suggested that K atoms would be mobile to some extent during FTS reaction conditions, and tend to occupy the most favorable sites independent of their initial position. The results obtained in this work provide valuable information on the interaction of K with cobalt surfaces, relevant for practical cobalt catalysts and their application in BTL processes.
[Mh] Termos MeSH primário: Cobalto/química
Modelos Químicos
Potássio/química
[Mh] Termos MeSH secundário: Adsorção
Biomassa
Catálise
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3G0H8C9362 (Cobalt); RWP5GA015D (Potassium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp00620a


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[PMID]:29324750
[Au] Autor:Tian X; Li C; Zhang M; Wan Y; Xie Z; Chen B; Li W
[Ad] Endereço:National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, National Engineering Technology Research Center for Slow and Controlled Release Fertilizers, College of Resources and Environment, Shandong Agricultural University, Tai'an, Shandong, China.
[Ti] Título:Biochar derived from corn straw affected availability and distribution of soil nutrients and cotton yield.
[So] Source:PLoS One;13(1):e0189924, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biochar application as a soil amendment has been proposed as a strategy to improve soil fertility and increase crop yields. However, the effects of successive biochar applications on cotton yields and nutrient distribution in soil are not well documented. A three-year field study was conducted to investigate the effects of successive biochar applications at different rates on cotton yield and on the soil nutrient distribution in the 0-100 cm soil profile. Biochar was applied at 0, 5, 10, and 20 t ha-1 (expressed as Control, BC5, BC10, and BC20, respectively) for each cotton season, with identical doses of chemical fertilizers. Biochar enhanced the cotton lint yield by 8.0-15.8%, 9.3-13.9%, and 9.2-21.9% in 2013, 2014, and 2015, respectively, and high levels of biochar application achieved high cotton yields each year. Leaching of soil nitrate was reduced, while the pH values, soil organic carbon, total nitrogen (N), and available K content of the 0-20 cm soil layer were increased in 2014 and 2015. However, the changes in the soil available P content were less substantial. This study suggests that successive biochar amendments have the potential to enhance cotton productivity and soil fertility while reducing nitrate leaching.
[Mh] Termos MeSH primário: Carvão Vegetal
Gossypium
Solo/química
Zea mays/química
[Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio
Nitrogênio/análise
Fósforo/análise
Potássio/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Soil); 0 (biochar); 16291-96-6 (Charcoal); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen); RWP5GA015D (Potassium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189924


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[PMID]:29227079
[Au] Autor:Kоbyli nska LI; Havrylyuk DY; Mitina NE; Zaichenko AS; Lesyk RB; Zіme nkovsky BS; Stoika RS
[Ti] Título:Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier
[So] Source:Ukr Biochem J;88(1):51-60, 2016 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare the effect of new synthetic 4-thiazolidinone derivatives (potential anticancer compounds denoted as 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyethylene glycol-containing nanoscale polymeric carrier on the biochemical indicators of nephrotoxicity in blood serum of rats. The concentration of total protein, urea, creatinine, glucose, ions of sodium, potassium, calcium, iron and chloride was measured. It was found that after injection of the investigated compounds, the concentration of sodium cations and chloride anions in blood serum was increased compared with control (untreated animals). Doxorubicin's injection was accompanied by a decrease in the concentration of iron cations. The concentration of total protein, urea and creatinine decreased under the influence of the studied compounds. Complexation of these аntineoplastic substances with a synthetic polymeric nanocarrier lowered the concentration of the investigated metabolites substantially compared to the effect of these compounds in free form. The normalization of concentration of total protein, urea and creatinine in blood serum of rats treated with complexes of the studied compounds with the polymeric carrier comparing with increased concentration of these indicators at the introduction of such compounds in free form was found.
[Mh] Termos MeSH primário: Antineoplásicos/toxicidade
Rim/efeitos dos fármacos
Nanoestruturas/administração & dosagem
Polietilenoglicóis/química
Tiazolidinas/toxicidade
[Mh] Termos MeSH secundário: Animais
Animais não Endogâmicos
Antineoplásicos/síntese química
Glicemia/metabolismo
Proteínas Sanguíneas/metabolismo
Cálcio/sangue
Cloretos/sangue
Creatinina/sangue
Doxorrubicina/toxicidade
Portadores de Fármacos/administração & dosagem
Compostos de Epóxi/química
Ferro/sangue
Rim/metabolismo
Masculino
Metacrilatos/química
Nanoestruturas/química
Poliacetilenos/química
Potássio/sangue
Ratos
Sódio/sangue
Tiazolidinas/síntese química
Testes de Toxicidade Aguda
Ureia/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Blood Glucose); 0 (Blood Proteins); 0 (Chlorides); 0 (Drug Carriers); 0 (Epoxy Compounds); 0 (Methacrylates); 0 (Thiazolidines); 25067-58-7 (Polyacetylenes); 30IQX730WE (Polyethylene Glycols); 80168379AG (Doxorubicin); 8W8T17847W (Urea); 9NEZ333N27 (Sodium); AYI8EX34EU (Creatinine); E1UOL152H7 (Iron); R8WN29J8VF (glycidyl methacrylate); RWP5GA015D (Potassium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.01.051


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[PMID]:29172497
[Au] Autor:An D; Yang L; Liu B; Wang TJ; Kan C
[Ad] Endereço:Department of Chemical Engineering, Tsinghua University , Beijing 100084, China.
[Ti] Título:Diffusion Performance of Fertilizer Nutrient through Polymer Latex Film.
[So] Source:J Agric Food Chem;65(50):10868-10874, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Matching the nutrient release rate of coated fertilizer with the nutrient uptake rate of the crop is the best way to increase the utilization efficiency of nutrients and reduce environmental pollution from the fertilizer. The diffusion property and mechanism of nutrients through the film are the theoretical basis for the product pattern design of coated fertilizers. For the coated fertilizer with a single-component nutrient, an extended solution-diffusion model was used to describe the difference of nutrient release rate, and the release rate is proportional to the permeation coefficient and the solubility of the nutrient. For the double- and triple-component fertilizer of N-K, N-P, and N-P-K, because of the interaction among nutrient molecules and ions, the release rates of different nutrients were significantly affected by the components in the composite fertilizer. Coating the single-component fertilizer (i.e., nitrogen fertilizer, phosphate fertilizer, and potash fertilizer) first and subsequently bulk blending is expected to be a promising way to adjust flexibly the nutrient release rate to meet the nutrient uptake rate of the crop.
[Mh] Termos MeSH primário: Produtos Agrícolas/metabolismo
Fertilizantes/análise
Látex/química
Nitrogênio/química
Fosfatos/química
Potássio/química
[Mh] Termos MeSH secundário: Difusão
Cinética
Nitrogênio/metabolismo
Fosfatos/metabolismo
Polímeros/química
Potássio/metabolismo
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Latex); 0 (Phosphates); 0 (Polymers); N762921K75 (Nitrogen); RWP5GA015D (Potassium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04225



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