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  1 / 2051 MEDLINE  
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[PMID]:29291276
[Au] Autor:Shields BE; Moye MS; Bayon R; Sperry SM; Wanat KA
[Ad] Endereço:1 Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
[Ti] Título:A Hairy Situation: Laser Hair Removal after Oral Reconstruction.
[So] Source:Ann Otol Rhinol Laryngol;127(3):205-208, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To present a case series of 4 patients who underwent postoperative hair removal using the long-pulsed Alexandrite or Nd:YAG laser following intraoral cutaneous flap reconstruction. METHODS: Patients underwent epilation in dermatology clinic with long-pulsed Alexandrite or Nd:YAG lasers, spaced 8 weeks apart, until hair removal was achieved. RESULTS: All patients achieved improvement in hair removal regardless of initial flap donor site with significant improvement in quality of life and minimal side effects. CONCLUSIONS: The long-pulsed Alexandrite and Nd:YAG represent safe and effective treatment options to improve patient quality of life following intraoral flap repair following excision of malignancy.
[Mh] Termos MeSH primário: Remoção de Cabelo/métodos
Terapia a Laser
Complicações Pós-Operatórias
Qualidade de Vida
Transplante de Pele/efeitos adversos
Retalhos Cirúrgicos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Berílio/uso terapêutico
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/cirurgia
Feminino
Seres Humanos
Terapia a Laser/instrumentação
Terapia a Laser/métodos
Lasers
Masculino
Meia-Idade
Neoplasias Bucais/patologia
Neoplasias Bucais/cirurgia
Procedimentos Cirúrgicos Bucais/efeitos adversos
Procedimentos Cirúrgicos Bucais/métodos
Complicações Pós-Operatórias/psicologia
Complicações Pós-Operatórias/terapia
Transplante de Pele/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (alexandrite); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417750930


  2 / 2051 MEDLINE  
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[PMID]:29222990
[Au] Autor:Ryken N; Al-Barri B; Blake W; Taylor A; Tack FMG; Van Ranst E; Bodé S; Boeckx P; Verdoodt A
[Ad] Endereço:Department of Soil Management, Ghent University, Ghent, Belgium. Electronic address: nick.ryken@ugent.be.
[Ti] Título:Rapid and irreversible sorption behavior of Be assessed to evaluate its use as a catchment sediment tracer.
[So] Source:J Environ Radioact;182:108-116, 2018 Feb.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Beryllium-7 ( Be) has been used as a sediment tracer to evaluate soil redistribution rates at hillslopes and as a tool to estimate sediment residence time in river systems. A key assumption for the use of Be as a sediment tracer is the rapid and irreversible sorption of Be upon contact with the soil particles. However, recent studies have raised questions about the validity of these assumptions. Seven soil types were selected to assess the adsorption rate of Be on the soil particles, subsequently an extraction experiment was performed to assess the rate of desorption. Next, different treatments were applied to assess the impact of soil pH, fertilizer, humic acid and organic matter on the adsorption of Be. Finally, the influence of regularly occurring cations present on the soil complex on the adsorption of Be on pure clay minerals was evaluated. The adsorption rate experiment showed a rapid and nearly complete sorption of Be for Luvisols and Cambisols under agriculture. For a temperate climate Stagnosol under forest and two highly weathered tropical Ferralsols sorption of Be was less rapid and less complete. This may result in an incomplete adsorption of Be on these three soils when runoff initiates, which could lead to an overestimation of erosion rates and sediment residence time. Additional observations were made during the extraction experiment, showing a significant loss of Be from the forest Stagnosol and a stable binding of Be to the arable soils. Of the different treatments applied, only pH showed to be of influence. Finally, Ca and NH on the soil complex had only a limited effect on the adsorption of Be, while Al in combination with a low pH inhibits the adsorption of Be on the exchange complex of the pure clay minerals. All these findings more rigorously support the use of Be as a soil redistribution tracer in arable soils in a temperate climate at a hillslope scale. The use of Be in highly weathered Ferralsols or forest rich environments should be limited to avoid overestimations of erosion rates. The spatially extended use of Be to evaluate residence times of sediments should be avoided in catchments with rapid changing environmental parameters as they might influence the sorption behavior of Be.
[Mh] Termos MeSH primário: Berílio/análise
Monitoramento de Radiação/métodos
Radioisótopos/análise
Poluentes Radioativos do Solo/análise
[Mh] Termos MeSH secundário: Adsorção
Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Beryllium-7); 0 (Radioisotopes); 0 (Soil Pollutants, Radioactive); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


  3 / 2051 MEDLINE  
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[PMID]:28965023
[Au] Autor:Dueñas C; Gordo E; Liger E; Cabello M; Cañete S; Pérez M; Torre-Luque P
[Ad] Endereço:Department of Applied Physics I, Faculty of Sciences, University of Málaga, Málaga, Spain. Electronic address: mcduenas@uma.es.
[Ti] Título:Be, Pb and K depositions over 11 years in Málaga.
[So] Source:J Environ Radioact;178-179:325-334, 2017 Nov.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The monthly bulk depositional fluxes of three natural radionuclides ( Be, Pb and K) were measured at a Mediterranean coastal station (Málaga) over an 11-year period from 2005 to 2015. The mean annual depositional fluxes of Be, Pb and K were 1215, 144 and 67 Bq m year respectively, showing a clear seasonal trend with minimum values recorded during summer and maximum values in winter. The rainfall regime with dry summers allows estimating the dry deposition. Assuming constant dry deposition through each year, Be, Pb and K would account for 12.5, 26.5 and 33% of the bulk fallout respectively which indicates that deposition for Pb and K are significantly higher than Be. The precipitation-normalized enrichment factor alpha used to explain seasonal variations in the depositional fluxes of radionuclides with respect the rainfall, indicates higher depositional fluxes during spring and summer than expected from the amount of rainfall. Despite their different origin, Pb and Be monthly depositional fluxes have strong correlation. The atmospheric deposition fluxes of Be, Pb and K were controlled mainly by the amount of rainfall (r = 0.89, 0.91 and 0.66 respectively). Moreover, principal component analysis was applied to the datasets and deposition of radionuclides and rainfall in the same component highlighting the importance of the washout mechanism. The mean depositional velocity of aerosols evaluated using Be and Pb are similar and are compared to other published values.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Berílio/análise
Radioisótopos de Chumbo/análise
Radioisótopos de Potássio/análise
Monitoramento de Radiação
[Mh] Termos MeSH secundário: Aerossóis
Estações do Ano
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Air Pollutants, Radioactive); 0 (Lead Radioisotopes); 0 (Potassium Radioisotopes); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


  4 / 2051 MEDLINE  
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[PMID]:28872302
[Au] Autor:Ermakov YA; Kamaraju K; Dunina-Barkovskaya A; Vishnyakova KS; Yegorov YE; Anishkin A; Sukharev S
[Ad] Endereço:Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences , Leninsky Prospect 31, Moscow 117071, Russia.
[Ti] Título:High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid.
[So] Source:Biochemistry;56(40):5457-5470, 2017 Oct 10.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Beryllium has multiple industrial applications, but its manufacture is associated with a serious occupational risk of developing chronic inflammation in the lungs known as berylliosis, or chronic beryllium disease. Although the Be -induced abnormal immune responses have recently been linked to a specific MHC-II allele, the nature of long-lasting granulomas is not fully understood. Here we show that Be binds with a micromolar affinity to phosphatidylserine (PS), the major surface marker of apoptotic cells. Isothermal titration calorimetry indicates that, like that of Ca , binding of Be to PS liposomes is largely entropically driven, likely by massive desolvation. Be exerts a compacting effect on PS monolayers, suggesting cross-linking through coordination by both phosphates and carboxyls in multiple configurations, which were visualized in molecular dynamics simulations. Electrostatic modification of PS membranes by Be includes complete neutralization of surface charges at ∼30 µM, accompanied by an increase in the boundary dipole potential. The data suggest that Be can displace Ca from the surface of PS, and being coordinated in a tight shell of four oxygens, it can mask headgroups from Ca -mediated recognition by PS receptors. Indeed, 48 µM Be added to IC-21 cultured macrophages specifically suppresses binding and engulfment of PS-coated silica beads or aged erythrocytes. We propose that Be adsorption at the surface of apoptotic cells may potentially prevent normal phagocytosis, thus causing accumulation of secondary necrotic foci and the resulting chronic inflammation.
[Mh] Termos MeSH primário: Berílio/metabolismo
Fosfatidilserinas/metabolismo
[Mh] Termos MeSH secundário: Macrófagos/metabolismo
Conformação Molecular
Simulação de Dinâmica Molecular
Fosfatidilserinas/química
Eletricidade Estática
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphatidylserines); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00644


  5 / 2051 MEDLINE  
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[PMID]:28838766
[Au] Autor:Tonelli M; Wiebe N; Bello A; Field CJ; Gill JS; Hemmelgarn BR; Holmes DT; Jindal K; Klarenbach SW; Manns BJ; Thadhani R; Kinniburgh D; Alberta Kidney Disease Network
[Ad] Endereço:Department of Medicine, University of Calgary, Calgary, Canada. Electronic address: tonelli.admin@ucalgary.ca.
[Ti] Título:Concentrations of Trace Elements in Hemodialysis Patients: A Prospective Cohort Study.
[So] Source:Am J Kidney Dis;70(5):696-704, 2017 Nov.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Low concentrations and excessive concentrations of trace elements have been commonly reported in hemodialysis patients, but available studies have several important limitations. STUDY DESIGN: Random sample of patients drawn from a prospective cohort. SETTING & PARTICIPANTS: 198 incident hemodialysis patients treated in 3 Canadian centers. MEASUREMENTS: We used mass spectrometry to measure plasma concentrations of the 25 elements at baseline, 6 months, 1 year, and 2 years following enrollment in the cohort. We focused on low concentrations of zinc, selenium, and manganese and excessive concentrations of lead, arsenic, and mercury; low and excessive concentrations of the other 19 trace elements were treated as exploratory analyses. Low and excessive concentrations were based on the 5th and 95th percentile plasma concentrations from healthy reference populations. RESULTS: At all 4 occasions, low zinc, selenium, and manganese concentrations were uncommon in study participants (≤5.1%, ≤1.8%, and ≤0.9% for zinc, selenium, and manganese, respectively) and a substantial proportion of participants had concentrations that exceeded the 95th percentile (≥65.2%, ≥74.2%, and ≥19.7%, respectively). Almost all participants had plasma lead concentrations above the 95th percentile at all time points. The proportion of participants with plasma arsenic concentrations exceeding the 95th percentile was relatively constant over time (9.1%-9.8%); the proportion with plasma mercury concentrations that exceeded the 95th percentile varied between 15.2% and 29.3%. Low arsenic, platinum, tungsten, and beryllium concentrations were common (>50%), as were excessive cobalt, manganese, zinc, vanadium, cadmium, selenium, barium, antimony, nickel, molybdenum, lead, and chromium concentrations. CONCLUSIONS: There was no evidence that low zinc, selenium, or manganese concentrations exist in most contemporary Canadian hemodialysis patients. Some patients have excessive plasma arsenic and mercury concentrations, and excessive lead concentrations were common. These findings require further investigation.
[Mh] Termos MeSH primário: Falência Renal Crônica/sangue
Oligoelementos/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antimônio/sangue
Arsênico/sangue
Bário/sangue
Berílio/sangue
Cádmio/sangue
Cromo/sangue
Cobalto/sangue
Estudos de Coortes
Feminino
Seres Humanos
Falência Renal Crônica/terapia
Chumbo/sangue
Masculino
Manganês/sangue
Espectrometria de Massas
Mercúrio/sangue
Meia-Idade
Molibdênio/sangue
Níquel/sangue
Platina/sangue
Estudos Prospectivos
Diálise Renal
Selênio/sangue
Tungstênio/sangue
Vanádio/sangue
Adulto Jovem
Zinco/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trace Elements); 00BH33GNGH (Cadmium); 00J9J9XKDE (Vanadium); 0R0008Q3JB (Chromium); 24GP945V5T (Barium); 2P299V784P (Lead); 3G0H8C9362 (Cobalt); 42Z2K6ZL8P (Manganese); 49DFR088MY (Platinum); 7OV03QG267 (Nickel); 81AH48963U (Molybdenum); 9IT35J3UV3 (Antimony); FXS1BY2PGL (Mercury); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc); N712M78A8G (Arsenic); OW5102UV6N (Beryllium); V9306CXO6G (Tungsten)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  6 / 2051 MEDLINE  
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[PMID]:28711160
[Au] Autor:Courtier J; Sdraulig S; Hirth G
[Ad] Endereço:Australian Radiation Protection and Nuclear Safety Agency (ARPANSA), 619 Lower Plenty Road, Yallambie, Victoria 3085, Australia. Electronic address: Jane.Courtier@arpansa.gov.au.
[Ti] Título:Be and Pb wet/dry deposition in Melbourne, Australia and the development of deployable units for radiological emergency monitoring.
[So] Source:J Environ Radioact;178-179:419-425, 2017 Nov.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A large stainless-steel collection tray (with a surface area of one square metre) was purpose built and mounted on the roof of the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) building at Yallambie, Victoria, Australia. Using this system two years' worth of wet/dry deposition samples have been collected and analysed. Smaller portable units were also developed for deployment in an emergency and/or for environmental monitoring. The cosmogenic radionuclide Be and the naturally occurring terrestrial radionuclide Pb have been used to validate the systems. The data from the smaller units was successfully compared to the larger permanent collection unit for validation, thus finding the portable units fit for purpose. Monitoring of wet and dry fallout deposition is an important response to radiological emergencies. It can provide useful information in verifying predictive models of radionuclide atmospheric transport and dispersion, in addition to providing local deposition data.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Berílio/análise
Radioisótopos de Chumbo/análise
Monitoramento de Radiação/instrumentação
[Mh] Termos MeSH secundário: Austrália
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Radioactive); 0 (Lead Radioisotopes); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


  7 / 2051 MEDLINE  
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[PMID]:28651065
[Au] Autor:Montenero MP; Dilbone EK; Waples JT
[Ad] Endereço:School of Freshwater Sciences, University of Wisconsin-Milwaukee, 600 East Greenfield Avenue, Milwaukee, WI 53204, United States.
[Ti] Título:The removal of particle-reactive radionuclides in shallow water: Bottom scavenging versus particle settling of iodine-131 and beryllium-7.
[So] Source:J Environ Radioact;177:128-134, 2017 Oct.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In pelagic waters, the removal of particle-reactive radionuclides is controlled by nuclide sorption to particles and subsequent settling by gravity. However, in shallow nearshore waters, the dominant mechanism of nuclide scavenging is not so clear. Understanding how particle-reactive radionuclides are scavenged from the water column is critical if these tracers are to be used as proxies of particle flux in shallow aquatic systems. In this study, we present evidence that the removal of particle-reactive radionuclides in nearshore and turbulent waters is primarily controlled by bottom scavenging. Specifically, we measured both water column and bottom sediment activities of sewage-sourced iodine-131 ( I, t ½ = 8.02 days) and atmospherically-sourced beryllium-7 ( Be, t ½ = 53.3 days) in a semi-enclosed harbor. We show that the water column Be/ I flux ratio that is required to sustain observed harbor bottom inventories of both nuclides is incongruent with Be/ I activity ratios on water column particles, and (2) I and Be derived mass fluxes of particulate matter to the harbor bottom are in concordance with each other and independently made estimates of river sediment loading to the harbor only when bottom scavenging of both particle-bound and dissolved (<0.7 µm) nuclide fractions are considered.
[Mh] Termos MeSH primário: Berílio/análise
Recuperação e Remediação Ambiental/métodos
Radioisótopos do Iodo/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Monitoramento de Radiação
Poluentes Radioativos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Water Pollutants, Radioactive); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  8 / 2051 MEDLINE  
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[PMID]:28471788
[Au] Autor:Friedmann DP; Buckley S; Mishra V
[Ad] Endereço:Westlake Dermatology Clinical Research Center, Westlake Dermatology & Cosmetic Surgery, Austin, Texas Division of Dermatology and Cutaneous Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
[Ti] Título:Localized Cutaneous Argyria From a Nasal Piercing Successfully Treated With a Picosecond 755-nm Q-Switched Alexandrite Laser.
[So] Source:Dermatol Surg;43(8):1094-1095, 2017 08.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Argiria/etiologia
Argiria/radioterapia
Piercing Corporal
Terapia a Laser/métodos
Lasers de Estado Sólido/uso terapêutico
Nariz/cirurgia
[Mh] Termos MeSH secundário: Adulto
Berílio
Feminino
Seres Humanos
Prata/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (alexandrite); 3M4G523W1G (Silver); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001162


  9 / 2051 MEDLINE  
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[PMID]:28314187
[Au] Autor:Saleh IH; Abdel-Halim AA
[Ad] Endereço:Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, P.O. Box 832, EL-Shatby, Alexandria, Egypt. Electronic address: ibshsh@yahoo.com.
[Ti] Título:Be in soil, deposited dust and atmospheric air and its using to infer soil erosion along Alexandria region, Egypt.
[So] Source:J Environ Radioact;172:24-29, 2017 Jun.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the radioactivity behavior of Be in surface soil, airborne and deposited dust along Alexandria region in Egypt. The results obtained were used to predict scavenging processes of Be from surface soil to infer soil erosion and land vulnerable to accelerated sea-level rise. The areal activity concentrations of Be in surface soil were investigated in 30 undisturbed sites and Be inventories were determined via deposited dust in 10 locations. Results of the former were found to be ranged from 78 Bq/m to 104 Bq/m . High levels were observed in western sites associated with high dust deposition rate. On the other hand, low levels were found in the eastern sites, those may be attributed to scavenging processes such as land erosion toward the direction to the sea. The effective removal rates of Be were calculated using the box-model, showing a broad special trend of inventories generally decreasing eastwards. The scavenging rates were ranged between 3.13 yr in western sites to 5.34 yr in eastern ones which denote that the east of the city suffers from rapid soil erosion. The airborne Be was monthly monitored along the period from October 2014 to September 2015 through one site located at the mid of the city. The results revealed lower values in winter and autumn than in summer and spring ranged between 6.2 mBq/m and 10.5 mBq/m . These levels are comparable with that in other world regions and the seasonal variations are associated with the prevailing climatic conditions in Alexandria region.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Atmosfera/química
Berílio/análise
Monitoramento de Radiação
Radioisótopos/análise
[Mh] Termos MeSH secundário: Poeira/análise
Egito
Fenômenos Geológicos
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Radioactive); 0 (Dust); 0 (Radioisotopes); 0 (Soil); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


  10 / 2051 MEDLINE  
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[PMID]:28259842
[Au] Autor:Schubauer-Berigan MK; Couch JR; Deddens JA
[Ad] Endereço:Division of Surveillance, Hazard Evaluations and Field Studies, U.S. National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
[Ti] Título:Is beryllium-induced lung cancer caused only by soluble forms and high exposure levels?
[So] Source:Occup Environ Med;74(8):601-603, 2017 Aug.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The US Occupational Safety and Health Administration (OSHA) recently proposed a permissible exposure limit of 0.2 µg/m for beryllium, based partly on extrapolated estimates of lung cancer risk from a pooled occupational cohort. The purpose of the present analysis was to evaluate whether cohort members exposed at lower levels to mainly insoluble forms of beryllium exhibit increased risk of lung cancer. METHODS: We conducted Cox proportional hazards regression analyses among 75 lung cancer cases in age-based risk sets within two lower exposure plants in the pooled cohort followed from 1940 to 2005. We used categorical and power models to evaluate exposure-response patterns for mean and cumulative beryllium exposures in the two-plant cohort, comparing findings with the full pooled cohort. We also evaluated the distribution of exposure-years in each cohort by solubility class (soluble, insoluble and mixed). RESULTS: 98% of workers in the two-plant cohort were hired between 1955 and 1969. The mean beryllium exposure averaged 1.3 µg/m and the predominant form was insoluble. Adjusting for confounders, we observed a monotonic increase in lung cancer mortality across exposure categories in the two-plant cohort. The exposure-response coefficients (per unit ln exposure) were 0.270 (p=0.061) for mean exposure and 0.170 (p=0.033) for cumulative exposure, compared with 0.155 and 0.094 (respectively) in the full cohort. CONCLUSION: The low-exposure levels at these two plants and the predominance of insoluble beryllium suggest that the overall pooled cohort findings on which OSHA's lung cancer risk assessment is based are relevant for current workers exposed to any form of beryllium.
[Mh] Termos MeSH primário: Berílio/efeitos adversos
Neoplasias Pulmonares/induzido quimicamente
Neoplasias Pulmonares/epidemiologia
Doenças Profissionais/induzido quimicamente
Doenças Profissionais/epidemiologia
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Estudos de Coortes
Seres Humanos
Indústrias
Exposição Ocupacional/análise
Modelos de Riscos Proporcionais
Fatores de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
OW5102UV6N (Beryllium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-104064



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