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[PMID]:29395083
[Au] Autor:Yamagishi Y; Oya K; Matsuura A; Abe H
[Ad] Endereço:Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Chiba 263-8522, Japan. Electronic address: afha3649@chiba-u.jp.
[Ti] Título:Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
[So] Source:Biochem Biophys Res Commun;496(3):834-839, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two types of Arp2/3 complex inhibitors, CK-666/636 and CK-548/869, are commonly used to study Arp2/3 complex-dependent actin assembly both in vitro and in vivo. However, we found that CK-548 and CK-869 directly suppress microtubule (MT) assembly independent of the actin cytoskeleton. Treatment of cultured mammalian cells with 50 µM CK-869 dramatically decreased MT networks and, instead, accumulated tubulin at the cell periphery, as did nocodazole that inhibits MT assembly. An in vitro MT-sedimentation assay revealed that CK-548 and CK-869 significantly suppressed MT polymerization. In budding yeast, although CK-548 and CK-869 are reported to lack binding abilities in the yeast Arp3, CK-548 treatment decreased cytoplasmic MT at several tens of micromolar concentrations. In addition, we found that the effects of CK-548 and CK-869 on MT assembly varied according to species. We propose that CK-548 and CK-869 are not suitable for studying the cytoskeleton in living cells.
[Mh] Termos MeSH primário: Complexo 2-3 de Proteínas Relacionadas à Actina/antagonistas & inibidores
Complexo 2-3 de Proteínas Relacionadas à Actina/metabolismo
Microtúbulos/fisiologia
Compostos Organosselênicos/administração & dosagem
Compostos de Organossilício/administração & dosagem
Tiazóis/administração & dosagem
Tubulina (Proteína)/metabolismo
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Drosophila melanogaster/metabolismo
Fibroblastos/efeitos dos fármacos
Fibroblastos/fisiologia
Gálio
Índio
Camundongos
Microtúbulos/efeitos dos fármacos
Células NIH 3T3
Ratos
Saccharomyces cerevisiae/metabolismo
Especificidade da Espécie
Moduladores de Tubulina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Actin-Related Protein 2-3 Complex); 0 (CK-0993548); 0 (CK-869); 0 (In(0.3)Ga(0.7)N); 0 (Organoselenium Compounds); 0 (Organosilicon Compounds); 0 (Thiazoles); 0 (Tubulin); 0 (Tubulin Modulators); 045A6V3VFX (Indium); CH46OC8YV4 (Gallium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE


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[PMID]:28548372
[Au] Autor:Siriwardana A; Thompson J; van Leeuwen PJ; Doig S; Kalsbeek A; Emmett L; Delprado W; Wong D; Samaratunga H; Haynes AM; Coughlin G; Stricker P
[Ad] Endereço:St Vincent's Prostate Cancer Centre, St Vincent's Clinic, Sydney, NSW, Australia.
[Ti] Título:Initial multicentre experience of gallium-PSMA PET/CT guided robot-assisted salvage lymphadenectomy: acceptable safety profile but oncological benefit appears limited.
[So] Source:BJU Int;120(5):673-681, 2017 Nov.
[Is] ISSN:1464-410X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the safety and short-term oncological outcomes of gallium-labelled prostate-specific membrane antigen ( Ga-PSMA) positron-emission tomography (PET)/computed tomography (CT)-directed robot-assisted salvage node dissection (RASND) for prostate cancer oligometastatic nodal recurrence. MATERIALS AND METHODS: Between February 2014 and April 2016, 35 patients across two centres underwent RASND for Ga-PSMA PET/CT-detected oligometastatic nodal recurrence. RASND was performed using targeted pelvic dissection, unilateral extended pelvic template or bilateral extended pelvic template dissection, depending on previous pelvic treatment and extent/location of nodal disease. Complications were reported using the Clavien-Dindo classification system. Definitions of prostate-specific antigen (PSA) treatment response to RASND were defined as 6-week PSA <0.2 ng/mL (broad definition) or PSA <0.05 ng/mL (strict definition) in those who had undergone primary prostatectomy, and 6-week PSA level < post-radiotherapy nadir in those who had undergone primary radiotherapy. Biochemical recurrence (BCR) after RASND was defined as a PSA >0.2 ng/mL or PSA > nadir, for those who had undergone primary prostatectomy and primary radiotherapy, respectively. Predictors of treatment response were analysed using univariate binary logistic regression. RESULTS: A total of 58 lesions suspicious for lymph node metastases (LNM) in 35 patients were detected on Ga-PSMA imaging. A total of 32 patients (91%) had histopathologically proven LNM at RASND, with a total of 87 LNM and a median (interquartile range) of 2 (1-3) LNM per patient. In all, eight patients (23%) experienced complications, all Clavien-Dindo grade ≤2. Treatment response was seen in 15 (43%) and 11 patients (31%), using the broad and strict definitions, respectively. BCR-free survival and clinical recurrence-free survival at a median follow-up of 12 months were 23% and 66%, respectively, for the entire cohort. Bilateral template dissection was the only significant univariate predictor of treatment response in our cohort. CONCLUSIONS: Although RASND appears safe and feasible, less than half of our cohort had a treatment response, and less than a quarter experienced BCR-free survival at 12-month median follow-up. Ga-PSMA imaging underestimates micro-metastatic disease, therefore RASND will rarely be curative. Strict patient selection and restricting RASND to clinical trials is recommended. Long-term follow-up from such trials is required to further assess potential quality of life and mortality benefits.
[Mh] Termos MeSH primário: Gálio/uso terapêutico
Excisão de Linfonodo
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Neoplasias da Próstata
Procedimentos Cirúrgicos Robóticos
Terapia de Salvação
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Excisão de Linfonodo/efeitos adversos
Excisão de Linfonodo/estatística & dados numéricos
Masculino
Meia-Idade
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/efeitos adversos
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/estatística & dados numéricos
Antígeno Prostático Específico/sangue
Neoplasias da Próstata/epidemiologia
Neoplasias da Próstata/patologia
Neoplasias da Próstata/cirurgia
Estudos Retrospectivos
Procedimentos Cirúrgicos Robóticos/efeitos adversos
Procedimentos Cirúrgicos Robóticos/estatística & dados numéricos
Terapia de Salvação/efeitos adversos
Terapia de Salvação/estatística & dados numéricos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
CH46OC8YV4 (Gallium); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.1111/bju.13919


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[PMID]:28542623
[Au] Autor:Choi SR; Britigan BE; Moran DM; Narayanasamy P
[Ad] Endereço:Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
[Ti] Título:Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages.
[So] Source:PLoS One;12(5):e0177987, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:New treatments and novel drugs are required to counter the growing problem of drug-resistant strains of Mycobacterium tuberculosis (M.tb). Our approach against drug resistant M.tb, as well as other intracellular pathogens, is by targeted drug delivery using nanoformulations of drugs already in use, as well as drugs in development. Among the latter are gallium (III) (Ga)-based compounds. In the current work, six different types of Ga and rifampin nanoparticles were prepared in such a way as to enhance targeting of M.tb infected-macrophages. They were then tested for their ability to inhibit growth of a fully pathogenic strain (H37Rv) or a non-pathogenic strain (H37Ra) of M.tb. Encapsulating Ga in folate- or mannose-conjugated block copolymers provided sustained Ga release for 15 days and significantly inhibited M.tb growth in human monocyte-derived macrophages. Nanoformulations with dendrimers encapsulating Ga or rifampin also showed promising anti-tuberculous activity. The nanoparticles co-localized with M.tb containing phagosomes, as measured by detection of mature cathepsin D (34 kDa, lysosomal hydrogenase). They also promoted maturation of the phagosome, which would be expected to increase macrophage-mediated killing of the organism. Delivery of Ga or rifampin in the form of nanoparticles to macrophages offers a promising approach for the development of new therapeutic anti-tuberculous drugs.
[Mh] Termos MeSH primário: Gálio/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/microbiologia
Nanopartículas Metálicas/química
Mycobacterium tuberculosis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antituberculosos/química
Antituberculosos/farmacologia
Catepsina D/genética
Catepsina D/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Dendrímeros/química
Ácido Fólico/química
Galectina 3/genética
Galectina 3/metabolismo
Gálio/análise
Gálio/metabolismo
Seres Humanos
Macrófagos/citologia
Macrófagos/metabolismo
Manose/química
Mycobacterium tuberculosis/fisiologia
Tamanho da Partícula
Fagossomos/metabolismo
Fagossomos/microbiologia
Polímeros/química
Rifampina/química
Rifampina/farmacologia
Virulência/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents); 0 (Dendrimers); 0 (Galectin 3); 0 (Polymers); 935E97BOY8 (Folic Acid); CH46OC8YV4 (Gallium); EC 3.4.23.5 (Cathepsin D); PHA4727WTP (Mannose); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177987


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[PMID]:28525874
[Au] Autor:Filella M; Rodríguez-Murillo JC
[Ad] Endereço:Institute F.-A. Forel, University of Geneva, Boulevard Carl-Vogt 66, CH-1205 Geneva, Switzerland. Electronic address: montserrat.filella@unige.ch.
[Ti] Título:Less-studied TCE: are their environmental concentrations increasing due to their use in new technologies?
[So] Source:Chemosphere;182:605-616, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The possible environmental impact of the recent increase in use of a group of technology-critical elements (Nb, Ta, Ga, In, Ge and Te) is analysed by reviewing published concentration profiles in environmental archives (ice cores, ombrotrophic peat bogs, freshwater sediments and moss surveys) and evaluating temporal trends in surface waters. No increase has so far been recorded. The low potential direct emissions of these elements, resulting from their absolute low production levels, make it unlikely that the increasing use of these elements in modern technology has any noticeable effect on their environmental concentrations on a global scale. This holds particularly true for those of these elements that are probably emitted in relatively high amounts from other human activities (i.e., coal combustion and non-ferrous smelting), such as In, the most studied element of the group.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Poluentes Ambientais/análise
Desenvolvimento Industrial/tendências
Metais Pesados/análise
[Mh] Termos MeSH secundário: Gálio
Germânio
Seres Humanos
Índio
Nióbio
Tantálio
Tecnécio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Metals, Heavy); 00072J7XWS (Germanium); 045A6V3VFX (Indium); 05175J654G (Niobium); 6424HBN274 (Tantalum); 7440-26-8 (Technetium); CH46OC8YV4 (Gallium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


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[PMID]:28395152
[Au] Autor:Qi J; Deng J; Qian K; Tian L; Li J; He K; Huang X; Cheng Z; Zheng Y; Wang Y
[Ad] Endereço:School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China; Qinzhou University, 12 Binhai Avenue, Qinzhou, Guangxi, China.
[Ti] Título:Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle.
[So] Source:Eur J Med Chem;134:34-42, 2017 Jul 07.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Two types of 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes, which are 2:1 and 1:1 ligand/Ga(III) complexes, were synthesized and determined by X-ray single crystal diffraction. The antiproliferative activity of these Ga(III) complexes have been examined to illuminate the structure-activity relationships essential to form Ga(III) complexes with remarkable anticancer activity. In addition, Ga(III) complexes where the metal/ligand ratio was 1:1 (C4) had observably higher antiproliferative activity than 1:2 (C3). Ga(III) complexes caused a marked increase of caspase-3 and 9 activity in NCI-H460 cells compared to the metal free ligand. Caspase activation was somewhat mediated by the release of Cyt C from mitochondria after incubation with selected agents. Both types of Ga(III) complexes showed more effective in inhibition of the G1/S transition than the ligand alone.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Complexos de Coordenação/farmacologia
Gálio/farmacologia
Piridinas/farmacologia
Tiossemicarbazonas/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/química
Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Caspase 9/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Complexos de Coordenação/química
Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais
Gálio/química
Seres Humanos
Modelos Moleculares
Neoplasias/tratamento farmacológico
Neoplasias/metabolismo
Neoplasias/patologia
Piridinas/química
Relação Estrutura-Atividade
Tiossemicarbazonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Pyridines); 0 (Thiosemicarbazones); 26445-06-7 (pyridinecarboxaldehyde); CH46OC8YV4 (Gallium); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:28377468
[Au] Autor:Juneau D; Golfam M; Hazra S; Zuckier LS; Garas S; Redpath C; Bernick J; Leung E; Chih S; Wells G; Beanlands RS; Chow BJ
[Ad] Endereço:From the Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ontario, Canada (D.J., S.H., C.R., J.B., S.C., G.W., R.S.B.B., B.J.W.C.); Division of Nuclear Medicine, Department of Medicine, University of Ottawa, Ontario, Canada (M.G., L.S.Z., S.G., E.L.); and Divisio
[Ti] Título:Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging in the Diagnosis of Cardiac Implantable Electronic Device Infection: A Systematic Review and Meta-Analysis.
[So] Source:Circ Cardiovasc Imaging;10(4), 2017 Apr.
[Is] ISSN:1942-0080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The use of cardiac implantable electronic devices (CIED) is increasing, and their associated infections result in significant morbidity and mortality. The introduction of better cardiac imaging techniques could be useful for diagnosing this condition and guiding therapy. Our objective was to systematically assess the diagnostic accuracy of Fluor-18-fluorodeoxyglucose positron emission tomography and computed tomography, labeled leukocyte scintigraphy (LS), and Gallium-67 citrate scintigraphy for the diagnosis of CIED infection. METHODS AND RESULTS: A systematic review of the literature and meta-analysis on the use of all 3 modalities in CIED infection were conducted. Pooled sensitivity, specificity, and summary receiver operating characteristic curves of each imaging modalities were determined. The literature search identified 2493 articles. A total of 13 articles (11 studies for F-FDG PET-CT and 2 for LS), met the inclusion criteria. No studies for Ga citrate scintigraphy met the inclusion criteria. The pooled sensitivity of F-FDG PET-CT for the diagnosis of CIED infection was 87% (95% CI, 82%-91%) and pooled specificity was 94% (95% CI, 88%-98%). The summary receiver operating characteristic curve analysis demonstrated good overall accuracy, with an area under the curve of 0.935. There were insufficient data to do a meta-analysis for LS, but both studies reported sensitivity above 90% and specificity of 100%. CONCLUSIONS: Both F-FDG PET-CT and LS yield high sensitivity, specificity, and accuracy, and thus seem to be useful for the diagnosis of CIED infection, based on robust data for F-FDG PET-CT but limited data for LS. When available, F-FDG PET-CT may be preferred.
[Mh] Termos MeSH primário: Desfibriladores Implantáveis/efeitos adversos
Coração Auxiliar/efeitos adversos
Técnicas de Diagnóstico Molecular
Marca-Passo Artificial/efeitos adversos
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Infecções Relacionadas à Prótese/diagnóstico por imagem
Tomografia Computadorizada de Emissão de Fóton Único
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Área Sob a Curva
Distribuição de Qui-Quadrado
Citratos/administração & dosagem
Feminino
Fluordesoxiglucose F18/administração & dosagem
Gálio/administração & dosagem
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Infecções Relacionadas à Prótese/microbiologia
Curva ROC
Compostos Radiofarmacêuticos/administração & dosagem
Reprodutibilidade dos Testes
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Citrates); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); CH46OC8YV4 (Gallium); HT6C49L0ZP (gallium citrate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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[PMID]:28347458
[Au] Autor:Huayhuaz JA; Vitorino HA; Campos OS; Serrano SH; Kaneko TM; Espósito BP
[Ad] Endereço:Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo,Av. Prof. Lineu Prestes, 748, 05508-000, São Paulo, SP, Brazil.
[Ti] Título:Desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the Trojan Horse Effect.
[So] Source:J Trace Elem Med Biol;41:16-22, 2017 May.
[Is] ISSN:1878-3252
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. Thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (Trojan Horse Effect). Desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. The complexes Me(dfo) and Me(dfcaf) (Me=Al and Ga ) were synthesized and characterized by mass spectroscopy and cyclic voltammetry. Their relative stabilities were studied through competitive equilibria with fluorescent probes calcein, fluorescein-desferrioxamine and 8-hydroxyquinoline. Me(dfo) and Me(dfcaf) were consistently more toxic than free Me against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, demonstrating the Trojan Horse Effect. Wide spectrum antimicrobial action can be obtained by loading non-essential or toxic metal ions to microbes via a convenient siderophore carrier.
[Mh] Termos MeSH primário: Alumínio/farmacologia
Antibacterianos/farmacologia
Antioxidantes/farmacologia
Cafeína/farmacologia
Desferroxamina/farmacologia
Gálio/farmacologia
[Mh] Termos MeSH secundário: Alumínio/química
Antibacterianos/química
Antioxidantes/química
Cafeína/química
Candida albicans/efeitos dos fármacos
Desferroxamina/química
Relação Dose-Resposta a Droga
Portadores de Fármacos/química
Portadores de Fármacos/farmacologia
Escherichia coli/efeitos dos fármacos
Gálio/química
Testes de Sensibilidade Microbiana
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Drug Carriers); 3G6A5W338E (Caffeine); CH46OC8YV4 (Gallium); CPD4NFA903 (Aluminum); J06Y7MXW4D (Deferoxamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE


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[PMID]:28258230
[Au] Autor:Richter K; Van den Driessche F; Coenye T
[Ad] Endereço:Department of Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, University of Adelaide, 37a Woodville Road, Woodville South, SA 5011, Australia.
[Ti] Título:Innovative approaches to treat biofilm-related infections.
[So] Source:Essays Biochem;61(1):61-70, 2017 Feb 28.
[Is] ISSN:1744-1358
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required. In this review, we present three such strategies to combat biofilm-related infections with the important human pathogen : (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics and (iii) the use of 'non-antibiotics' with antibiofilm activity identified through screening of repurposing libraries.
[Mh] Termos MeSH primário: Biofilmes
Invenções
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/fisiologia
[Mh] Termos MeSH secundário: Animais
Reposicionamento de Medicamentos
Gálio/farmacologia
Gálio/uso terapêutico
Seres Humanos
Percepção de Quorum/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
CH46OC8YV4 (Gallium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1042/EBC20160056


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[PMID]:28231503
[Au] Autor:Zeng C; Gonzalez-Alvarez A; Orenstein E; Field JA; Shadman F; Sierra-Alvarez R
[Ad] Endereço:Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ 85704, USA. Electronic address: chaozeng@email.arizona.edu.
[Ti] Título:Ecotoxicity assessment of ionic As(III), As(V), In(III) and Ga(III) species potentially released from novel III-V semiconductor materials.
[So] Source:Ecotoxicol Environ Saf;140:30-36, 2017 Jun.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:III-V materials such as indium arsenide (InAs) and gallium arsenide (GaAs) are increasingly used in electronic and photovoltaic devices. The extensive application of these materials may lead to release of III-V ionic species during semiconductor manufacturing or disposal of decommissioned devices into the environment. Although arsenic is recognized as an important contaminant due to its high toxicity, there is a lack of information about the toxic effects of indium and gallium ions. In this study, acute toxicity of As(III), As(V), In(III) and Ga(III) species was evaluated using two microbial assays testing for methanogenic activity and O uptake, as well as two bioassays targeting aquatic organisms, including the marine bacterium Aliivibrio fischeri (bioluminescence inhibition) and the crustacean Daphnia magna (mortality). The most noteworthy finding was that the toxicity is mostly impacted by the element tested. Secondarily, the toxicity of these species also depended on the bioassay target. In(III) and Ga(III) were not or only mildly toxic in the experiments. D. magna was the most sensitive organism for In(III) and Ga(III) with 50% lethal concentrations of 0.5 and 3.4mM, respectively. On the other hand, As(III) and As(V) caused clear inhibitory effects, particularly in the methanogenic toxicity bioassay. The 50% inhibitory concentrations of both arsenic species towards methanogens were about 0.02mM, which is lower than the regulated maximum allowable daily effluent discharge concentration (2.09mg/L or 0.03mM) for facilities manufacturing electronic components in the US. Overall, the results indicate that the ecotoxicity of In(III) and Ga(III) is much lower than that of the As species tested. This finding is important in filling the knowledge gap regarding the ecotoxicology of In and Ga.
[Mh] Termos MeSH primário: Arseniatos/toxicidade
Arsenitos/toxicidade
Gálio/toxicidade
Índio/toxicidade
Semicondutores
[Mh] Termos MeSH secundário: Aliivibrio fischeri/efeitos dos fármacos
Animais
Arseniatos/análise
Arsenicais/análise
Arsenitos/análise
Bioensaio/métodos
Daphnia/efeitos dos fármacos
Ecotoxicologia
Gálio/análise
Índio/análise
Íons
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Ions); 045A6V3VFX (Indium); 27FC46GA44 (gallium arsenide); CH46OC8YV4 (Gallium); J1A23S0911 (indium arsenide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:28198608
[Au] Autor:Howard DP; Marchand P; McCafferty L; Carmalt CJ; Parkin IP; Darr JA
[Ad] Endereço:Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom.
[Ti] Título:High-Throughput Continuous Hydrothermal Synthesis of Transparent Conducting Aluminum and Gallium Co-doped Zinc Oxides.
[So] Source:ACS Comb Sci;19(4):239-245, 2017 Apr 10.
[Is] ISSN:2156-8944
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High-throughput continuous hydrothermal flow synthesis was used to generate a library of aluminum and gallium-codoped zinc oxide nanoparticles of specific atomic ratios. Resistivities of the materials were determined by Hall Effect measurements on heat-treated pressed discs and the results collated into a conductivity-composition map. Optimal resistivities of ∼9 × 10 Ω cm were reproducibly achieved for several samples, for example, codoped ZnO with 2 at% Ga and 1 at% Al. The optimum sample on balance of performance and cost was deemed to be ZnO codoped with 3 at% Al and 1 at% Ga.
[Mh] Termos MeSH primário: Alumínio/química
Gálio/química
Nanopartículas/química
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Condutividade Elétrica
Luz
Tamanho da Partícula
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
CH46OC8YV4 (Gallium); CPD4NFA903 (Aluminum); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1021/acscombsci.6b00118



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