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[PMID]: 29395083 [Au] Autor: Yamagishi Y; Oya K; Matsuura A; Abe H [Ad] Endereço: Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Chiba 263-8522, Japan. Electronic address: afha3649@chiba-u.jp. [Ti] Título: Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. [So] Source: Biochem Biophys Res Commun;496(3):834-839, 2018 02 12. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Two types of Arp2/3 complex inhibitors, CK-666/636 and CK-548/869, are commonly used to study Arp2/3 complex-dependent actin assembly both in vitro and in vivo. However, we found that CK-548 and CK-869 directly suppress microtubule (MT) assembly independent of the actin cytoskeleton. Treatment of cultured mammalian cells with 50 µM CK-869 dramatically decreased MT networks and, instead, accumulated tubulin at the cell periphery, as did nocodazole that inhibits MT assembly. An in vitro MT-sedimentation assay revealed that CK-548 and CK-869 significantly suppressed MT polymerization. In budding yeast, although CK-548 and CK-869 are reported to lack binding abilities in the yeast Arp3, CK-548 treatment decreased cytoplasmic MT at several tens of micromolar concentrations. In addition, we found that the effects of CK-548 and CK-869 on MT assembly varied according to species. We propose that CK-548 and CK-869 are not suitable for studying the cytoskeleton in living cells. [Mh] Termos MeSH primário: Complexo 2-3 de Proteínas Relacionadas à Actina/antagonistas & inibidores Complexo 2-3 de Proteínas Relacionadas à Actina/metabolismo Microtúbulos/fisiologia Compostos Organosselênicos/administração & dosagem Compostos de Organossilício/administração & dosagem Tiazóis/administração & dosagem Tubulina (Proteína)/metabolismo [Mh] Termos MeSH secundário: Animais Relação Dose-Resposta a Droga Drosophila melanogaster/metabolismo Fibroblastos/efeitos dos fármacos Fibroblastos/fisiologia Gálio Índio Camundongos Microtúbulos/efeitos dos fármacos Células NIH 3T3 Ratos Saccharomyces cerevisiae/metabolismo Especificidade da Espécie Moduladores de Tubulina [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Actin-Related Protein 2-3 Complex); 0 (CK-0993548); 0 (CK-869); 0 (In(0.3)Ga(0.7)N); 0 (Organoselenium Compounds); 0 (Organosilicon Compounds); 0 (Thiazoles); 0 (Tubulin); 0 (Tubulin Modulators); 045A6V3VFX (Indium); CH46OC8YV4 (Gallium) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180204 [St] Status: MEDLINE

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[PMID]: 28548372 [Au] Autor: Siriwardana A; Thompson J; van Leeuwen PJ; Doig S; Kalsbeek A; Emmett L; Delprado W; Wong D; Samaratunga H; Haynes AM; Coughlin G; Stricker P [Ad] Endereço: St Vincent's Prostate Cancer Centre, St Vincent's Clinic, Sydney, NSW, Australia. [Ti] Título: Initial multicentre experience of gallium-PSMA PET/CT guided robot-assisted salvage lymphadenectomy: acceptable safety profile but oncological benefit appears limited. [So] Source: BJU Int;120(5):673-681, 2017 Nov. [Is] ISSN: 1464-410X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To evaluate the safety and short-term oncological outcomes of gallium-labelled prostate-specific membrane antigen ( Ga-PSMA) positron-emission tomography (PET)/computed tomography (CT)-directed robot-assisted salvage node dissection (RASND) for prostate cancer oligometastatic nodal recurrence. MATERIALS AND METHODS: Between February 2014 and April 2016, 35 patients across two centres underwent RASND for Ga-PSMA PET/CT-detected oligometastatic nodal recurrence. RASND was performed using targeted pelvic dissection, unilateral extended pelvic template or bilateral extended pelvic template dissection, depending on previous pelvic treatment and extent/location of nodal disease. Complications were reported using the Clavien-Dindo classification system. Definitions of prostate-specific antigen (PSA) treatment response to RASND were defined as 6-week PSA <0.2 ng/mL (broad definition) or PSA <0.05 ng/mL (strict definition) in those who had undergone primary prostatectomy, and 6-week PSA level < post-radiotherapy nadir in those who had undergone primary radiotherapy. Biochemical recurrence (BCR) after RASND was defined as a PSA >0.2 ng/mL or PSA > nadir, for those who had undergone primary prostatectomy and primary radiotherapy, respectively. Predictors of treatment response were analysed using univariate binary logistic regression. RESULTS: A total of 58 lesions suspicious for lymph node metastases (LNM) in 35 patients were detected on Ga-PSMA imaging. A total of 32 patients (91%) had histopathologically proven LNM at RASND, with a total of 87 LNM and a median (interquartile range) of 2 (1-3) LNM per patient. In all, eight patients (23%) experienced complications, all Clavien-Dindo grade ≤2. Treatment response was seen in 15 (43%) and 11 patients (31%), using the broad and strict definitions, respectively. BCR-free survival and clinical recurrence-free survival at a median follow-up of 12 months were 23% and 66%, respectively, for the entire cohort. Bilateral template dissection was the only significant univariate predictor of treatment response in our cohort. CONCLUSIONS: Although RASND appears safe and feasible, less than half of our cohort had a treatment response, and less than a quarter experienced BCR-free survival at 12-month median follow-up. Ga-PSMA imaging underestimates micro-metastatic disease, therefore RASND will rarely be curative. Strict patient selection and restricting RASND to clinical trials is recommended. Long-term follow-up from such trials is required to further assess potential quality of life and mortality benefits. [Mh] Termos MeSH primário: Gálio/uso terapêutico Excisão de Linfonodo Tomografia Computadorizada com Tomografia por Emissão de Pósitrons Neoplasias da Próstata Procedimentos Cirúrgicos Robóticos Terapia de Salvação [Mh] Termos MeSH secundário: Idoso Seres Humanos Excisão de Linfonodo/efeitos adversos Excisão de Linfonodo/estatística & dados numéricos Masculino Meia-Idade Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/efeitos adversos Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/estatística & dados numéricos Antígeno Prostático Específico/sangue Neoplasias da Próstata/epidemiologia Neoplasias da Próstata/patologia Neoplasias da Próstata/cirurgia Estudos Retrospectivos Procedimentos Cirúrgicos Robóticos/efeitos adversos Procedimentos Cirúrgicos Robóticos/estatística & dados numéricos Terapia de Salvação/efeitos adversos Terapia de Salvação/estatística & dados numéricos Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY [Nm] Nome de substância: CH46OC8YV4 (Gallium); EC 3.4.21.77 (Prostate-Specific Antigen) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171024 [Lr] Data última revisão: 171024 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170527 [St] Status: MEDLINE [do] DOI: 10.1111/bju.13919

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[PMID]: 28542623 [Au] Autor: Choi SR; Britigan BE; Moran DM; Narayanasamy P [Ad] Endereço: Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America. [Ti] Título: Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages. [So] Source: PLoS One;12(5):e0177987, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: New treatments and novel drugs are required to counter the growing problem of drug-resistant strains of Mycobacterium tuberculosis (M.tb). Our approach against drug resistant M.tb, as well as other intracellular pathogens, is by targeted drug delivery using nanoformulations of drugs already in use, as well as drugs in development. Among the latter are gallium (III) (Ga)-based compounds. In the current work, six different types of Ga and rifampin nanoparticles were prepared in such a way as to enhance targeting of M.tb infected-macrophages. They were then tested for their ability to inhibit growth of a fully pathogenic strain (H37Rv) or a non-pathogenic strain (H37Ra) of M.tb. Encapsulating Ga in folate- or mannose-conjugated block copolymers provided sustained Ga release for 15 days and significantly inhibited M.tb growth in human monocyte-derived macrophages. Nanoformulations with dendrimers encapsulating Ga or rifampin also showed promising anti-tuberculous activity. The nanoparticles co-localized with M.tb containing phagosomes, as measured by detection of mature cathepsin D (34 kDa, lysosomal hydrogenase). They also promoted maturation of the phagosome, which would be expected to increase macrophage-mediated killing of the organism. Delivery of Ga or rifampin in the form of nanoparticles to macrophages offers a promising approach for the development of new therapeutic anti-tuberculous drugs. [Mh] Termos MeSH primário: Gálio/farmacologia Macrófagos/efeitos dos fármacos Macrófagos/microbiologia Nanopartículas Metálicas/química Mycobacterium tuberculosis/efeitos dos fármacos [Mh] Termos MeSH secundário: Antituberculosos/química Antituberculosos/farmacologia Catepsina D/genética Catepsina D/metabolismo Sobrevivência Celular/efeitos dos fármacos Células Cultivadas Dendrímeros/química Ácido Fólico/química Galectina 3/genética Galectina 3/metabolismo Gálio/análise Gálio/metabolismo Seres Humanos Macrófagos/citologia Macrófagos/metabolismo Manose/química Mycobacterium tuberculosis/fisiologia Tamanho da Partícula Fagossomos/metabolismo Fagossomos/microbiologia Polímeros/química Rifampina/química Rifampina/farmacologia Virulência/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antitubercular Agents); 0 (Dendrimers); 0 (Galectin 3); 0 (Polymers); 935E97BOY8 (Folic Acid); CH46OC8YV4 (Gallium); EC 3.4.23.5 (Cathepsin D); PHA4727WTP (Mannose); VJT6J7R4TR (Rifampin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170915 [Lr] Data última revisão: 170915 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170526 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0177987

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[PMID]: 28525874 [Au] Autor: Filella M; Rodríguez-Murillo JC [Ad] Endereço: Institute F.-A. Forel, University of Geneva, Boulevard Carl-Vogt 66, CH-1205 Geneva, Switzerland. Electronic address: montserrat.filella@unige.ch. [Ti] Título: Less-studied TCE: are their environmental concentrations increasing due to their use in new technologies? [So] Source: Chemosphere;182:605-616, 2017 Sep. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The possible environmental impact of the recent increase in use of a group of technology-critical elements (Nb, Ta, Ga, In, Ge and Te) is analysed by reviewing published concentration profiles in environmental archives (ice cores, ombrotrophic peat bogs, freshwater sediments and moss surveys) and evaluating temporal trends in surface waters. No increase has so far been recorded. The low potential direct emissions of these elements, resulting from their absolute low production levels, make it unlikely that the increasing use of these elements in modern technology has any noticeable effect on their environmental concentrations on a global scale. This holds particularly true for those of these elements that are probably emitted in relatively high amounts from other human activities (i.e., coal combustion and non-ferrous smelting), such as In, the most studied element of the group. [Mh] Termos MeSH primário: Monitoramento Ambiental Poluentes Ambientais/análise Desenvolvimento Industrial/tendências Metais Pesados/análise [Mh] Termos MeSH secundário: Gálio Germânio Seres Humanos Índio Nióbio Tantálio Tecnécio [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Environmental Pollutants); 0 (Metals, Heavy); 00072J7XWS (Germanium); 045A6V3VFX (Indium); 05175J654G (Niobium); 6424HBN274 (Tantalum); 7440-26-8 (Technetium); CH46OC8YV4 (Gallium) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170922 [Lr] Data última revisão: 170922 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170520 [St] Status: MEDLINE

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[PMID]: 28395152 [Au] Autor: Qi J; Deng J; Qian K; Tian L; Li J; He K; Huang X; Cheng Z; Zheng Y; Wang Y [Ad] Endereço: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China; Qinzhou University, 12 Binhai Avenue, Qinzhou, Guangxi, China. [Ti] Título: Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle. [So] Source: Eur J Med Chem;134:34-42, 2017 Jul 07. [Is] ISSN: 1768-3254 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Two types of 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes, which are 2:1 and 1:1 ligand/Ga(III) complexes, were synthesized and determined by X-ray single crystal diffraction. The antiproliferative activity of these Ga(III) complexes have been examined to illuminate the structure-activity relationships essential to form Ga(III) complexes with remarkable anticancer activity. In addition, Ga(III) complexes where the metal/ligand ratio was 1:1 (C4) had observably higher antiproliferative activity than 1:2 (C3). Ga(III) complexes caused a marked increase of caspase-3 and 9 activity in NCI-H460 cells compared to the metal free ligand. Caspase activation was somewhat mediated by the release of Cyt C from mitochondria after incubation with selected agents. Both types of Ga(III) complexes showed more effective in inhibition of the G1/S transition than the ligand alone. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Complexos de Coordenação/farmacologia Gálio/farmacologia Piridinas/farmacologia Tiossemicarbazonas/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/química Apoptose/efeitos dos fármacos Caspase 3/metabolismo Caspase 9/metabolismo Pontos de Checagem do Ciclo Celular/efeitos dos fármacos Linhagem Celular Tumoral Proliferação Celular/efeitos dos fármacos Complexos de Coordenação/química Cristalografia por Raios X Ensaios de Seleção de Medicamentos Antitumorais Gálio/química Seres Humanos Modelos Moleculares Neoplasias/tratamento farmacológico Neoplasias/metabolismo Neoplasias/patologia Piridinas/química Relação Estrutura-Atividade Tiossemicarbazonas/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Pyridines); 0 (Thiosemicarbazones); 26445-06-7 (pyridinecarboxaldehyde); CH46OC8YV4 (Gallium); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170908 [Lr] Data última revisão: 170908 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170411 [St] Status: MEDLINE

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[PMID]: 28377468 [Au] Autor: Juneau D; Golfam M; Hazra S; Zuckier LS; Garas S; Redpath C; Bernick J; Leung E; Chih S; Wells G; Beanlands RS; Chow BJ [Ad] Endereço: From the Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ontario, Canada (D.J., S.H., C.R., J.B., S.C., G.W., R.S.B.B., B.J.W.C.); Division of Nuclear Medicine, Department of Medicine, University of Ottawa, Ontario, Canada (M.G., L.S.Z., S.G., E.L.); and Divisio [Ti] Título: Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging in the Diagnosis of Cardiac Implantable Electronic Device Infection: A Systematic Review and Meta-Analysis. [So] Source: Circ Cardiovasc Imaging;10(4), 2017 Apr. [Is] ISSN: 1942-0080 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: The use of cardiac implantable electronic devices (CIED) is increasing, and their associated infections result in significant morbidity and mortality. The introduction of better cardiac imaging techniques could be useful for diagnosing this condition and guiding therapy. Our objective was to systematically assess the diagnostic accuracy of Fluor-18-fluorodeoxyglucose positron emission tomography and computed tomography, labeled leukocyte scintigraphy (LS), and Gallium-67 citrate scintigraphy for the diagnosis of CIED infection. METHODS AND RESULTS: A systematic review of the literature and meta-analysis on the use of all 3 modalities in CIED infection were conducted. Pooled sensitivity, specificity, and summary receiver operating characteristic curves of each imaging modalities were determined. The literature search identified 2493 articles. A total of 13 articles (11 studies for F-FDG PET-CT and 2 for LS), met the inclusion criteria. No studies for Ga citrate scintigraphy met the inclusion criteria. The pooled sensitivity of F-FDG PET-CT for the diagnosis of CIED infection was 87% (95% CI, 82%-91%) and pooled specificity was 94% (95% CI, 88%-98%). The summary receiver operating characteristic curve analysis demonstrated good overall accuracy, with an area under the curve of 0.935. There were insufficient data to do a meta-analysis for LS, but both studies reported sensitivity above 90% and specificity of 100%. CONCLUSIONS: Both F-FDG PET-CT and LS yield high sensitivity, specificity, and accuracy, and thus seem to be useful for the diagnosis of CIED infection, based on robust data for F-FDG PET-CT but limited data for LS. When available, F-FDG PET-CT may be preferred. [Mh] Termos MeSH primário: Desfibriladores Implantáveis/efeitos adversos Coração Auxiliar/efeitos adversos Técnicas de Diagnóstico Molecular Marca-Passo Artificial/efeitos adversos Tomografia Computadorizada com Tomografia por Emissão de Pósitrons Infecções Relacionadas à Prótese/diagnóstico por imagem Tomografia Computadorizada de Emissão de Fóton Único [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Área Sob a Curva Distribuição de Qui-Quadrado Citratos/administração & dosagem Feminino Fluordesoxiglucose F18/administração & dosagem Gálio/administração & dosagem Seres Humanos Masculino Meia-Idade Valor Preditivo dos Testes Infecções Relacionadas à Prótese/microbiologia Curva ROC Compostos Radiofarmacêuticos/administração & dosagem Reprodutibilidade dos Testes Fatores de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Nm] Nome de substância: 0 (Citrates); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); CH46OC8YV4 (Gallium); HT6C49L0ZP (gallium citrate) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170509 [Lr] Data última revisão: 170509 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170406 [St] Status: MEDLINE

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[PMID]: 28347458 [Au] Autor: Huayhuaz JA; Vitorino HA; Campos OS; Serrano SH; Kaneko TM; Espósito BP [Ad] Endereço: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo,Av. Prof. Lineu Prestes, 748, 05508-000, São Paulo, SP, Brazil. [Ti] Título: Desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the Trojan Horse Effect. [So] Source: J Trace Elem Med Biol;41:16-22, 2017 May. [Is] ISSN: 1878-3252 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. Thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (Trojan Horse Effect). Desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. The complexes Me(dfo) and Me(dfcaf) (Me=Al and Ga ) were synthesized and characterized by mass spectroscopy and cyclic voltammetry. Their relative stabilities were studied through competitive equilibria with fluorescent probes calcein, fluorescein-desferrioxamine and 8-hydroxyquinoline. Me(dfo) and Me(dfcaf) were consistently more toxic than free Me against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, demonstrating the Trojan Horse Effect. Wide spectrum antimicrobial action can be obtained by loading non-essential or toxic metal ions to microbes via a convenient siderophore carrier. [Mh] Termos MeSH primário: Alumínio/farmacologia Antibacterianos/farmacologia Antioxidantes/farmacologia Cafeína/farmacologia Desferroxamina/farmacologia Gálio/farmacologia [Mh] Termos MeSH secundário: Alumínio/química Antibacterianos/química Antioxidantes/química Cafeína/química Candida albicans/efeitos dos fármacos Desferroxamina/química Relação Dose-Resposta a Droga Portadores de Fármacos/química Portadores de Fármacos/farmacologia Escherichia coli/efeitos dos fármacos Gálio/química Testes de Sensibilidade Microbiana Pseudomonas aeruginosa/efeitos dos fármacos Staphylococcus aureus/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Drug Carriers); 3G6A5W338E (Caffeine); CH46OC8YV4 (Gallium); CPD4NFA903 (Aluminum); J06Y7MXW4D (Deferoxamine) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170623 [Lr] Data última revisão: 170623 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170329 [St] Status: MEDLINE

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[PMID]: 28258230 [Au] Autor: Richter K; Van den Driessche F; Coenye T [Ad] Endereço: Department of Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, University of Adelaide, 37a Woodville Road, Woodville South, SA 5011, Australia. [Ti] Título: Innovative approaches to treat biofilm-related infections. [So] Source: Essays Biochem;61(1):61-70, 2017 Feb 28. [Is] ISSN: 1744-1358 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required. In this review, we present three such strategies to combat biofilm-related infections with the important human pathogen : (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics and (iii) the use of 'non-antibiotics' with antibiofilm activity identified through screening of repurposing libraries. [Mh] Termos MeSH primário: Biofilmes Invenções Infecções Estafilocócicas/tratamento farmacológico Infecções Estafilocócicas/microbiologia Staphylococcus aureus/fisiologia [Mh] Termos MeSH secundário: Animais Reposicionamento de Medicamentos Gálio/farmacologia Gálio/uso terapêutico Seres Humanos Percepção de Quorum/efeitos dos fármacos Staphylococcus aureus/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: CH46OC8YV4 (Gallium) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170619 [Lr] Data última revisão: 170619 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170305 [St] Status: MEDLINE [do] DOI: 10.1042/EBC20160056

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[PMID]: 28231503 [Au] Autor: Zeng C; Gonzalez-Alvarez A; Orenstein E; Field JA; Shadman F; Sierra-Alvarez R [Ad] Endereço: Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ 85704, USA. Electronic address: chaozeng@email.arizona.edu. [Ti] Título: Ecotoxicity assessment of ionic As(III), As(V), In(III) and Ga(III) species potentially released from novel III-V semiconductor materials. [So] Source: Ecotoxicol Environ Saf;140:30-36, 2017 Jun. [Is] ISSN: 1090-2414 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: III-V materials such as indium arsenide (InAs) and gallium arsenide (GaAs) are increasingly used in electronic and photovoltaic devices. The extensive application of these materials may lead to release of III-V ionic species during semiconductor manufacturing or disposal of decommissioned devices into the environment. Although arsenic is recognized as an important contaminant due to its high toxicity, there is a lack of information about the toxic effects of indium and gallium ions. In this study, acute toxicity of As(III), As(V), In(III) and Ga(III) species was evaluated using two microbial assays testing for methanogenic activity and O uptake, as well as two bioassays targeting aquatic organisms, including the marine bacterium Aliivibrio fischeri (bioluminescence inhibition) and the crustacean Daphnia magna (mortality). The most noteworthy finding was that the toxicity is mostly impacted by the element tested. Secondarily, the toxicity of these species also depended on the bioassay target. In(III) and Ga(III) were not or only mildly toxic in the experiments. D. magna was the most sensitive organism for In(III) and Ga(III) with 50% lethal concentrations of 0.5 and 3.4mM, respectively. On the other hand, As(III) and As(V) caused clear inhibitory effects, particularly in the methanogenic toxicity bioassay. The 50% inhibitory concentrations of both arsenic species towards methanogens were about 0.02mM, which is lower than the regulated maximum allowable daily effluent discharge concentration (2.09mg/L or 0.03mM) for facilities manufacturing electronic components in the US. Overall, the results indicate that the ecotoxicity of In(III) and Ga(III) is much lower than that of the As species tested. This finding is important in filling the knowledge gap regarding the ecotoxicology of In and Ga. [Mh] Termos MeSH primário: Arseniatos/toxicidade Arsenitos/toxicidade Gálio/toxicidade Índio/toxicidade Semicondutores [Mh] Termos MeSH secundário: Aliivibrio fischeri/efeitos dos fármacos Animais Arseniatos/análise Arsenicais/análise Arsenitos/análise Bioensaio/métodos Daphnia/efeitos dos fármacos Ecotoxicologia Gálio/análise Índio/análise Íons Testes de Toxicidade Aguda [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Ions); 045A6V3VFX (Indium); 27FC46GA44 (gallium arsenide); CH46OC8YV4 (Gallium); J1A23S0911 (indium arsenide) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170519 [Lr] Data última revisão: 170519 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170224 [St] Status: MEDLINE

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[PMID]: 28198608 [Au] Autor: Howard DP; Marchand P; McCafferty L; Carmalt CJ; Parkin IP; Darr JA [Ad] Endereço: Department of Chemistry, University College London , 20 Gordon Street, London WC1H 0AJ, United Kingdom. [Ti] Título: High-Throughput Continuous Hydrothermal Synthesis of Transparent Conducting Aluminum and Gallium Co-doped Zinc Oxides. [So] Source: ACS Comb Sci;19(4):239-245, 2017 Apr 10. [Is] ISSN: 2156-8944 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: High-throughput continuous hydrothermal flow synthesis was used to generate a library of aluminum and gallium-codoped zinc oxide nanoparticles of specific atomic ratios. Resistivities of the materials were determined by Hall Effect measurements on heat-treated pressed discs and the results collated into a conductivity-composition map. Optimal resistivities of ∼9 × 10 Ω cm were reproducibly achieved for several samples, for example, codoped ZnO with 2 at% Ga and 1 at% Al. The optimum sample on balance of performance and cost was deemed to be ZnO codoped with 3 at% Al and 1 at% Ga. [Mh] Termos MeSH primário: Alumínio/química Gálio/química Nanopartículas/química Óxido de Zinco/química [Mh] Termos MeSH secundário: Condutividade Elétrica Luz Tamanho da Partícula Propriedades de Superfície [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: CH46OC8YV4 (Gallium); CPD4NFA903 (Aluminum); SOI2LOH54Z (Zinc Oxide) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171107 [Lr] Data última revisão: 171107 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170216 [St] Status: MEDLINE [do] DOI: 10.1021/acscombsci.6b00118

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