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Pesquisa : D01.268.556.381 [Categoria DeCS]
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[PMID]:29395083
[Au] Autor:Yamagishi Y; Oya K; Matsuura A; Abe H
[Ad] Endereço:Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Chiba 263-8522, Japan. Electronic address: afha3649@chiba-u.jp.
[Ti] Título:Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
[So] Source:Biochem Biophys Res Commun;496(3):834-839, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two types of Arp2/3 complex inhibitors, CK-666/636 and CK-548/869, are commonly used to study Arp2/3 complex-dependent actin assembly both in vitro and in vivo. However, we found that CK-548 and CK-869 directly suppress microtubule (MT) assembly independent of the actin cytoskeleton. Treatment of cultured mammalian cells with 50 µM CK-869 dramatically decreased MT networks and, instead, accumulated tubulin at the cell periphery, as did nocodazole that inhibits MT assembly. An in vitro MT-sedimentation assay revealed that CK-548 and CK-869 significantly suppressed MT polymerization. In budding yeast, although CK-548 and CK-869 are reported to lack binding abilities in the yeast Arp3, CK-548 treatment decreased cytoplasmic MT at several tens of micromolar concentrations. In addition, we found that the effects of CK-548 and CK-869 on MT assembly varied according to species. We propose that CK-548 and CK-869 are not suitable for studying the cytoskeleton in living cells.
[Mh] Termos MeSH primário: Complexo 2-3 de Proteínas Relacionadas à Actina/antagonistas & inibidores
Complexo 2-3 de Proteínas Relacionadas à Actina/metabolismo
Microtúbulos/fisiologia
Compostos Organosselênicos/administração & dosagem
Compostos de Organossilício/administração & dosagem
Tiazóis/administração & dosagem
Tubulina (Proteína)/metabolismo
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Drosophila melanogaster/metabolismo
Fibroblastos/efeitos dos fármacos
Fibroblastos/fisiologia
Gálio
Índio
Camundongos
Microtúbulos/efeitos dos fármacos
Células NIH 3T3
Ratos
Saccharomyces cerevisiae/metabolismo
Especificidade da Espécie
Moduladores de Tubulina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Actin-Related Protein 2-3 Complex); 0 (CK-0993548); 0 (CK-869); 0 (In(0.3)Ga(0.7)N); 0 (Organoselenium Compounds); 0 (Organosilicon Compounds); 0 (Thiazoles); 0 (Tubulin); 0 (Tubulin Modulators); 045A6V3VFX (Indium); CH46OC8YV4 (Gallium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE


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[PMID]:29239435
[Au] Autor:Li Y; Tang A; Liu Z; Peng L; Yuan Y; Shi X; Yang C; Teng F
[Ad] Endereço:Department of Chemistry, School of Science, Beijing JiaoTong University, Beijing 100044, P. R. China. awtang@bjtu.edu.cn chy@bjtu.edu.cn.
[Ti] Título:Formation of uniform carrot-like Cu S -CuInS heteronanostructures assisted by citric acid at the oil/aqueous interface.
[So] Source:Dalton Trans;47(1):67-73, 2018 Jan 07.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple two-phase strategy was developed to prepare Cu S -CuInS heterostructures (HNS) at the oil/aqueous interface, in which the In(OH) phase was often obtained in the products due to the reaction between indium ions and hydroxyl ions in the aqueous phase. To prevent the formation of the In(OH) phase, citric acid was incorporated into the aqueous phase to assist in the synthesis of uniform carrot-like Cu S -CuInS semiconductor HNS at the oil/aqueous interface for the first time. By manipulating the dosage of citric acid and Cu/In precursor ratios, the morphology of the Cu S -CuInS HNS could be tailored from mushroom to carrot-like, and the presence of citric acid played a critical role in the synthesis of high-quality Cu S -CuInS HNS, which inhibited the formation of the In(OH) phase due to the formation of the indium(iii)-citric acid complex. The formation mechanism was studied by monitoring the morphology and phase evolution of the Cu S -CuInS HNS with reaction time, which revealed that the Cu S seeds were first formed and then the cation-exchange reaction directed the subsequent anisotropic growth of the Cu S -CuInS HNS.
[Mh] Termos MeSH primário: Ácido Cítrico/química
Cobre/química
Índio/química
Óleos/química
Sulfetos/química
Água/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils); 0 (Sulfides); 045A6V3VFX (Indium); 059QF0KO0R (Water); 2968PHW8QP (Citric Acid); 789U1901C5 (Copper)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1039/c7dt04274d


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[PMID]:28554024
[Au] Autor:Folens K; Du Laing G
[Ad] Endereço:Laboratory of Analytical Chemistry and Applied Ecochemistry, Department of Applied Analytical and Physical Chemistry, Ghent University, Coupure Links 653, 9000 Gent, Belgium. Electronic address: Karel.Folens@UGent.be.
[Ti] Título:Dispersion and solubility of In, Tl, Ta and Nb in the aquatic environment and intertidal sediments of the Scheldt estuary (Flanders, Belgium).
[So] Source:Chemosphere;183:401-409, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Certain specialty elements are indispensable in modern technologies for their particular properties. Yet, potential risks associated to the release of these elements at any stage, remains unknown. Therefore, the dispersion of indium (In), thallium (Tl), tantalum (Ta) and niobium (Nb) in the aquatic environment of the Scheldt estuary (Flanders, Belgium) was studied. Maximum concentrations in intertidal sediments of 101 ± 15 µg kg for In, 481 ± 37 µg kg for Tl, 88 ± 19 µg kg for Ta and 1162 ± 4 µg kg for Nb appeared on the sampling location closest to the river mouth, i.e. 57.5 km upstream. Their distribution in the intertidal sediments depends on the physicochemical sediment characteristics along the flow of the river Scheldt. The same was the case for most other metals and aluminum as their occurrence also correlated (p < 0.05) with the occurrence of In, Tl and Nb. While in general, studied elements correlate to the OM content and sulfur and phosphorus herein included, a relative enrichment of In, Tl and Nb was seen at Rupelmonde (92.0 km from the river mouth). Mainly the intertidal sediment silt fraction is capable of retaining the elements by exchanging with other ions in the mineral interlayer. Increasing salinity towards the river mouth can furthermore induce the formation of insoluble chloride species. Overall, the solubility of In, Tl, Ta and Nb appeared extremely low upon extraction of pore water from intertidal sediments saturated to 100% field capacity.
[Mh] Termos MeSH primário: Estuários
Sedimentos Geológicos/análise
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Bélgica
Monitoramento Ambiental
Sedimentos Geológicos/química
Índio/análise
Nióbio/análise
Rios/química
Solubilidade
Tantálio/análise
Tálio/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 045A6V3VFX (Indium); 05175J654G (Niobium); 6424HBN274 (Tantalum); AD84R52XLF (Thallium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28525874
[Au] Autor:Filella M; Rodríguez-Murillo JC
[Ad] Endereço:Institute F.-A. Forel, University of Geneva, Boulevard Carl-Vogt 66, CH-1205 Geneva, Switzerland. Electronic address: montserrat.filella@unige.ch.
[Ti] Título:Less-studied TCE: are their environmental concentrations increasing due to their use in new technologies?
[So] Source:Chemosphere;182:605-616, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The possible environmental impact of the recent increase in use of a group of technology-critical elements (Nb, Ta, Ga, In, Ge and Te) is analysed by reviewing published concentration profiles in environmental archives (ice cores, ombrotrophic peat bogs, freshwater sediments and moss surveys) and evaluating temporal trends in surface waters. No increase has so far been recorded. The low potential direct emissions of these elements, resulting from their absolute low production levels, make it unlikely that the increasing use of these elements in modern technology has any noticeable effect on their environmental concentrations on a global scale. This holds particularly true for those of these elements that are probably emitted in relatively high amounts from other human activities (i.e., coal combustion and non-ferrous smelting), such as In, the most studied element of the group.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Poluentes Ambientais/análise
Desenvolvimento Industrial/tendências
Metais Pesados/análise
[Mh] Termos MeSH secundário: Gálio
Germânio
Seres Humanos
Índio
Nióbio
Tantálio
Tecnécio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Metals, Heavy); 00072J7XWS (Germanium); 045A6V3VFX (Indium); 05175J654G (Niobium); 6424HBN274 (Tantalum); 7440-26-8 (Technetium); CH46OC8YV4 (Gallium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


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[PMID]:28476649
[Au] Autor:Liu L; Xiao YY; Ji YH; Liu MZ; Chen Y; Zeng YL; Zhang YG; Jin L
[Ad] Endereço:Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Southwest University School of Life Sciences, Chongqing 400715, China. Electronic address: liuli9901@126.com.
[Ti] Título:CuInS /ZnS QD exposure induces developmental toxicity, oxidative stress and DNA damage in rare minnow (Gobiocypris rarus) embryos and larvae.
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;198:19-27, 2017 Aug.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chinese rare minnow (Gobiocypris rarus) embryos were used as an experimental model to investigate the effects of CuInS /ZnS quantum dots (QDs) on the early life stages of G. rarus. Normal developmental parameters (survival rate, body length and average heart rate), biomarker genes [stress response (Hsp70), detoxification (Cyp1a), organizer function and axis formation (Wnt8α), and muscle (Mstn)], enzymatic activity and DNA damage were recorded as endpoints in the developing embryos/larvae after exposure until 96h post-fertilization (hpf). Reduced survival rate, decreased heart rate, altered body length, increased malformation rate, decreased hatching rate, advanced hatching time in response to low concentrations (50 and 100nmol/L) and delayed hatching time in response to high concentrations were observed after exposure, as were many other toxic effects, including pericardial edema and bent tails. The 72 hpf LC (median lethal concentration) was determined to be 624.364nmol/L. Treatment with certain concentrations of CuInS /ZnS QDs significantly increased the superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels and significantly induced DNA damage. After treatment with CuInS /ZnS QDs, the embryos showed highly up-regulated expression of Hsp70, Cyp1a and Wnt8a and significantly up-regulated expression of Mstn at 12 hpf. Overall, this study indicates that CuInS /ZnS QDs are potentially toxic to G. rarus embryos. The information presented in this study will be helpful for fully understanding the toxicity induced by CuInS /ZnS QDs in fish embryos.
[Mh] Termos MeSH primário: Cyprinidae/embriologia
Dano ao DNA/efeitos dos fármacos
Ecotoxicologia/métodos
Estresse Oxidativo/efeitos dos fármacos
Sulfetos/toxicidade
Compostos de Zinco/toxicidade
[Mh] Termos MeSH secundário: Animais
Cobre/toxicidade
Embrião não Mamífero/efeitos dos fármacos
Feminino
Proteínas de Peixes/genética
Regulação da Expressão Gênica/efeitos dos fármacos
Proteínas de Choque Térmico HSP70/genética
Frequência Cardíaca/efeitos dos fármacos
Índio/toxicidade
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Masculino
Nanopartículas/química
Nanopartículas/toxicidade
Pontos Quânticos/toxicidade
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); 0 (HSP70 Heat-Shock Proteins); 0 (Sulfides); 0 (Water Pollutants, Chemical); 0 (Zinc Compounds); 045A6V3VFX (Indium); 789U1901C5 (Copper); KPS085631O (zinc sulfide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


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[PMID]:28368691
[Au] Autor:Gondal MA; Dastageer MA; Oloore LE; Baig U; Rashid SG
[Ad] Endereço:a Laser Research Group, Department of Physics, Center of Excellence in Nanotechnology , King Fahd University of Petroleum and Minerals , Dhahran , Saudi Arabia.
[Ti] Título:Enhanced photo-catalytic activity of ordered mesoporous indium oxide nanocrystals in the conversion of CO into methanol.
[So] Source:J Environ Sci Health A Tox Hazard Subst Environ Eng;52(8):785-793, 2017 Jul 03.
[Is] ISSN:1532-4117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ordered mesoporous indium oxide nanocrystal (m-In O ) was synthesized by nanocasting technique, in which highly ordered mesoporous silca (SBA-15) was used as structural matrix. X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM) Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halanda (BJH) studies were carried out on m-In O and the results revealed that this material has a highly ordered mesoporous surface with reduced grain size, increased surface area and surface volume compared to the non porous indium oxide. The diffuse reluctance spectrum exhibited substantially improved light absorption efficiency in m-In O compared to normal indium oxide, however, no considerable change in the band gap energies of these materials was observed. When m-In O was used as a photo-catalyst in the photo-catalytic process of converting carbon dioxide (CO ) into methanol under the pulsed laser radiation of 266-nm wavelengths, an enhanced photo-catalytic activity with the quantum efficiency of 4.5% and conversion efficiency of 46.3% were observed. It was found that the methanol production yield in this chemical process is as high as 485 µlg h after 150 min of irradiation, which is substantially higher than the yields reported in the literature. It is quite clear from the results that the introduction of mesoporosity in indium oxide, and the consequent enhancement of positive attributes required for a photo-catalyst, transformed photo-catalytically weak indium oxide into an effective photo-catalyst for the conversion of CO into methanol.
[Mh] Termos MeSH primário: Dióxido de Carbono/análise
Índio/química
Metanol/análise
Nanopartículas/química
Dióxido de Silício/química
Raios Ultravioleta
[Mh] Termos MeSH secundário: Dióxido de Carbono/química
Dióxido de Carbono/efeitos da radiação
Catálise
Metanol/química
Metanol/efeitos da radiação
Microscopia Eletrônica de Varredura
Oxirredução
Tamanho da Partícula
Processos Fotoquímicos
Porosidade
Propriedades de Superfície
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (SBA-15); 045A6V3VFX (Indium); 142M471B3J (Carbon Dioxide); 4OO9KME22D (indium oxide); 7631-86-9 (Silicon Dioxide); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1080/10934529.2017.1305173


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[PMID]:28231503
[Au] Autor:Zeng C; Gonzalez-Alvarez A; Orenstein E; Field JA; Shadman F; Sierra-Alvarez R
[Ad] Endereço:Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ 85704, USA. Electronic address: chaozeng@email.arizona.edu.
[Ti] Título:Ecotoxicity assessment of ionic As(III), As(V), In(III) and Ga(III) species potentially released from novel III-V semiconductor materials.
[So] Source:Ecotoxicol Environ Saf;140:30-36, 2017 Jun.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:III-V materials such as indium arsenide (InAs) and gallium arsenide (GaAs) are increasingly used in electronic and photovoltaic devices. The extensive application of these materials may lead to release of III-V ionic species during semiconductor manufacturing or disposal of decommissioned devices into the environment. Although arsenic is recognized as an important contaminant due to its high toxicity, there is a lack of information about the toxic effects of indium and gallium ions. In this study, acute toxicity of As(III), As(V), In(III) and Ga(III) species was evaluated using two microbial assays testing for methanogenic activity and O uptake, as well as two bioassays targeting aquatic organisms, including the marine bacterium Aliivibrio fischeri (bioluminescence inhibition) and the crustacean Daphnia magna (mortality). The most noteworthy finding was that the toxicity is mostly impacted by the element tested. Secondarily, the toxicity of these species also depended on the bioassay target. In(III) and Ga(III) were not or only mildly toxic in the experiments. D. magna was the most sensitive organism for In(III) and Ga(III) with 50% lethal concentrations of 0.5 and 3.4mM, respectively. On the other hand, As(III) and As(V) caused clear inhibitory effects, particularly in the methanogenic toxicity bioassay. The 50% inhibitory concentrations of both arsenic species towards methanogens were about 0.02mM, which is lower than the regulated maximum allowable daily effluent discharge concentration (2.09mg/L or 0.03mM) for facilities manufacturing electronic components in the US. Overall, the results indicate that the ecotoxicity of In(III) and Ga(III) is much lower than that of the As species tested. This finding is important in filling the knowledge gap regarding the ecotoxicology of In and Ga.
[Mh] Termos MeSH primário: Arseniatos/toxicidade
Arsenitos/toxicidade
Gálio/toxicidade
Índio/toxicidade
Semicondutores
[Mh] Termos MeSH secundário: Aliivibrio fischeri/efeitos dos fármacos
Animais
Arseniatos/análise
Arsenicais/análise
Arsenitos/análise
Bioensaio/métodos
Daphnia/efeitos dos fármacos
Ecotoxicologia
Gálio/análise
Índio/análise
Íons
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Ions); 045A6V3VFX (Indium); 27FC46GA44 (gallium arsenide); CH46OC8YV4 (Gallium); J1A23S0911 (indium arsenide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:28222025
[Au] Autor:Farrugia FA; Martikos G; Surgeon C; Tzanetis P; Misiakos E; Zavras N; Charalampopoulos A
[Ti] Título:Radiology of the adrenal incidentalomas. Review of the literature.
[So] Source:Endocr Regul;51(1):35-51, 2017 Jan 01.
[Is] ISSN:1210-0668
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The term "adrenal incidentaloma" is a radiological term. Adrenal incidentalomas are adrenal tumors discovered in an imaging study that has been obtained for indications exclusive to adrenal conditions (Udelsman 2001; Linos 2003; Bulow et al. 2006; Anagnostis et al. 2009). This definition excludes patients undergoing imaging testing as part of staging and work-up for cancer (Grumbach et al. 2003; Anagnostis et al. 2009). Papierska et al. (2013) have added the prerequisite that the size of a tumor must be "greater than 1cm in diameter", in order to be called incidentaloma. Although in the most cases these masses are non-hypersecreting and benign, they still represent an important clinical concern because of the risk of malignancy or hormone hyperfunction (Barzon et al. 2003). Th e adrenal tumors belong to the commonest incidental findings having been discovered (Kanagarajah et al. 2012).
[Mh] Termos MeSH primário: Neoplasias do Córtex Suprarrenal/diagnóstico por imagem
Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem
Adenoma Adrenocortical/diagnóstico por imagem
Carcinoma Adrenocortical/diagnóstico por imagem
Feocromocitoma/diagnóstico por imagem
[Mh] Termos MeSH secundário: 3-Iodobenzilguanidina
Doença de Addison/diagnóstico por imagem
Doenças das Glândulas Suprarrenais/diagnóstico por imagem
Síndrome de Cushing/diagnóstico por imagem
Imagem de Difusão por Ressonância Magnética
Fluordesoxiglucose F18
Hemorragia/diagnóstico por imagem
Seres Humanos
Hiperaldosteronismo/diagnóstico por imagem
Índio
Radioisótopos de Índio
Linfoma/diagnóstico por imagem
Imagem por Ressonância Magnética
Mielolipoma/diagnóstico por imagem
Octreotida
Tomografia por Emissão de Pósitrons
Cintilografia
Compostos Radiofarmacêuticos
Tomografia Computadorizada por Raios X
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Indium Radioisotopes); 0 (Radiopharmaceuticals); 045A6V3VFX (Indium); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 35MRW7B4AD (3-Iodobenzylguanidine); RWM8CCW8GP (Octreotide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


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[PMID]:28114997
[Au] Autor:Zeng X; Yuan Y; Wang T; Wang H; Hu X; Fu Z; Zhang G; Liu B; Lu G
[Ad] Endereço:Department of Medical Imaging, Jingling Hospital, School of Medicine, Nanjing Universtiy, Nanjing, 210002, China.
[Ti] Título:Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds.
[So] Source:J Nanobiotechnology;15(1):9, 2017 Jan 23.
[Is] ISSN:1477-3155
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Currently, graphene oxide has attracted growing attention as a drug delivery system due to its unique characteristics. Furthermore, utilization of microRNAs as biomarkers and therapeutic strategies would be particularly attractive because of their biological mechanisms and relatively low toxicity. Therefore, we have developed functionalized nanocompounds consisted of graphene oxide, quantum dots and microRNA, which induced cancer cells apoptosis along with targeted imaging. RESULTS: In the present study, we synthesized a kind of graphene-P-gp loaded with miR-122-InP@ZnS quantum dots nanocomposites (GPMQNs) that, in the presence of glutathione, provides controlled release of miR-122. The miR-122 actively targeted liver tumor cells and induced their apoptosis, including drug-resistant liver tumor cells. We also explored the near-infrared fluorescence and potential utility for targeting imaging of InP@ZnS quantum dots. To further understand the molecular mechanism of GPMQNs-induced apoptosis of drug-resistant HepG2/ADM hepatoma cells, the relevant apoptosis proteins and signal pathways were explored in vitro and in vivo. Furthermore, near-infrared GPMQNs, which exhibited reduced photon scattering and auto-fluorescence, were applied for tumor imaging in vivo to allow for deep tissue penetration and three-dimensional imaging. CONCLUSION: In conclusion, techniques using GPMQNs could provide a novel targeted treatment for liver cancer, which possessed properties of targeted imaging, low toxicity, and controlled release.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/tratamento farmacológico
Sistemas de Liberação de Medicamentos
Grafite/química
Índio/química
Neoplasias Hepáticas/tratamento farmacológico
MicroRNAs/uso terapêutico
Nanocompostos/química
Fosfinas/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/uso terapêutico
Apoptose
Carcinoma Hepatocelular/diagnóstico por imagem
Liberação Controlada de Fármacos
Corantes Fluorescentes/química
Células Hep G2
Seres Humanos
Imagem Tridimensional
Neoplasias Hepáticas/diagnóstico por imagem
Camundongos
Camundongos Nus
Fototerapia
Pontos Quânticos/química
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Fluorescent Dyes); 0 (MIRN122 microRNA, human); 0 (MicroRNAs); 0 (Phosphines); 045A6V3VFX (Indium); 7782-42-5 (Graphite); SD36LG60G1 (indium phosphide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1186/s12951-016-0237-2


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[PMID]:28049906
[Au] Autor:Ono M; Oda S; Yasuda S; Mineno T; Okawa M; Kinjo J; Miyashita H; Yoshimitsu H; Nohara T; Miyahara K
[Ad] Endereço:School of Agriculture, Tokai University.
[Ti] Título:Acylated Glycosidic Acid Methyl Esters Generated from the Convolvulin Fraction of Rhizoma Jalapae Braziliensis by Treatment with Indium(III) Chloride in Methanol.
[So] Source:Chem Pharm Bull (Tokyo);65(1):107-111, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Four hexaglycosides of methyl 3S,12S-dihydroxyhexadecanoate (1-4) were provided after treatment of the crude convolvulin fraction from Rhizoma Jalapae Braziliensis (the root of Ipomoea operculata (GOMES) MART., Convolvulaceae) with indium(III) chloride in methanol. The structures of 1-4 were elucidated on the basis of spectroscopic and chemical methods. Their sugar moieties were partially acylated with organic acids including (3S,9R)-3,6:6,9-diepoxydecanoic (exogonic) acid, (E)-2-methylbut-2-enoic (tiglic) acid, and isovaleric acid.
[Mh] Termos MeSH primário: Ácidos/síntese química
Glicosídeos/síntese química
Índio/química
Metanol/química
Éteres Metílicos/síntese química
Resinas Vegetais/química
[Mh] Termos MeSH secundário: Ácidos/química
Acilação
Convolvulaceae/química
Glicosídeos/química
Éteres Metílicos/química
Estrutura Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids); 0 (Glycosides); 0 (Methyl Ethers); 0 (Resins, Plant); 0 (convolvulin); 045A6V3VFX (Indium); 31JB8MKF8Z (indium trichloride); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c16-00673



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