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  1 / 2399 MEDLINE  
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[PMID]:29331753
[Au] Autor:Tang B; Wan D; Wang YJ; Yi QY; Guo BH; Liu YJ
[Ad] Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China.
[Ti] Título:An iridium (III) complex as potent anticancer agent induces apoptosis and autophagy in B16 cells through inhibition of the AKT/mTOR pathway.
[So] Source:Eur J Med Chem;145:302-314, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A new ligand THPDP (THPDP = 11-(6,7,8,9-tetrahydrophenazin-2-yl)dipyrido[3,2-a:2',3'-c]phenazine) and its iridium(III) complex [Ir(ppy) (THPDP)]PF (Ir-1) was synthesized and characterized by elemental analysis, IR, ESI-MS, H NMR and C NMR. The cytotoxicity in vitro of the complex against cancer cells B16, A549, Eca-109, SGC-7901, BEL-7402 and normal NIH 3T3 cell lines was evaluated using MTT method. The IC values of the complex toward B16, A549 and Eca-109 cells are 1.0 ±â€¯0.02, 1.4 ±â€¯0.03 and 1.6 ±â€¯0.06 µM, respectively. The apoptosis was investigated with AO/EB and DAPI staining methods. The complex shows strong ability to inhibit the cell growth in B16, A549 and Eca-109 cells. Ir-1 can induce apoptosis, increase the intracellular ROS level, and cause a decrease in the mitochondrial membrane potential. The intracellular Ca level and the release of cytochrome c were studied under a fluorescent microscope. The cell invasion and autophagy were also performed, and the cell cycle arrest was assayed by flow cytometry. The expression of Bcl-2 family proteins, PI3K, AKT, mTOR, P-mTOR was investigated by western blot. The results show that the complex induces apoptosis through ROS-mediated mitochondria dysfunction and inhibition of AKT/mTOR pathways. These findings are helpful for design and synthesis of iridium(III) complexes as potent anticancer drugs.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Complexos de Coordenação/farmacologia
Irídio/farmacologia
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Serina-Treonina Quinases TOR/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/síntese química
Antineoplásicos/química
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Complexos de Coordenação/síntese química
Complexos de Coordenação/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Irídio/química
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Estrutura Molecular
Células NIH 3T3
Proteínas Proto-Oncogênicas c-akt/metabolismo
Relação Estrutura-Atividade
Serina-Treonina Quinases TOR/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 44448S9773 (Iridium); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  2 / 2399 MEDLINE  
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[PMID]:29331805
[Au] Autor:Yi QY; Wan D; Tang B; Wang YJ; Zhang WY; Du F; He M; Liu YJ
[Ad] Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China.
[Ti] Título:Synthesis, characterization and anticancer activity in vitro and in vivo evaluation of an iridium (III) polypyridyl complex.
[So] Source:Eur J Med Chem;145:338-349, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:An iridium (III) complex [Ir(ppy) (BDPIP)]PF (Ir-1) was reported to show high anticancer activity and may be used as a potent anticancer drug. In the current study, we designed and synthesized a novel iridium (III) complex and evaluated its potential inhibitory effect on the cancer cell growth in vitro and in vivo. This complex was found to display high cytotoxic activity in vitro and in vivo against A549 cell with a low IC value of 3.6 ± 0.3 µM and inhibiting percentage of tumor growth is 63.84% compared with the control. The complex also exhibited potencies superior to that of cisplatin toward A549 cell in vitro and in vivo. Further studies revealed that the complex can induce apoptosis and autophagy, enhance the ROS level, cause a decrease in the mitochondrial membrane potential and inhibit the cell invasion. Our findings indicated that the complex induced apoptosis in A549 through mitochondria dysfunction and PI3K/AKT/mTOR signaling pathways.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Complexos de Coordenação/farmacologia
Irídio/farmacologia
Piridinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Complexos de Coordenação/síntese química
Complexos de Coordenação/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Irídio/química
Camundongos
Camundongos Endogâmicos
Estrutura Molecular
Neoplasias Experimentais/tratamento farmacológico
Neoplasias Experimentais/patologia
Piridinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Pyridines); 44448S9773 (Iridium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  3 / 2399 MEDLINE  
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[PMID]:29199820
[Au] Autor:Shewring JR; Cankut AJ; McKenzie LK; Crowston BJ; Botchway SW; Weinstein JA; Edwards E; Ward MD
[Ad] Endereço:Department of Chemistry, University of Sheffield , Sheffield S3 7HF, U.K.
[Ti] Título:Multimodal Probes: Superresolution and Transmission Electron Microscopy Imaging of Mitochondria, and Oxygen Mapping of Cells, Using Small-Molecule Ir(III) Luminescent Complexes.
[So] Source:Inorg Chem;56(24):15259-15270, 2017 Dec 18.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We describe an Ir(III)-based small-molecule, multimodal probe for use in both light and electron microscopy. The direct correlation of data between light- and electron-microscopy-based imaging to investigate cellular processes at the ultrastructure level is a current challenge, requiring both dyes that must be brightly emissive for luminescence imaging and scatter electrons to give contrast for electron microscopy, at a single working concentration suitable for both methods. Here we describe the use of Ir(III) complexes as probes that provide excellent image contrast and quality for both luminescence and electron microscopy imaging, at the same working concentration. Significant contrast enhancement of cellular mitochondria was observed in transmission electron microscopy imaging, with and without the use of typical contrast agents. The specificity for cellular mitochondria was also confirmed with MitoTracker using confocal and 3D-structured illumination microscopy. These phosphorescent dyes are part of a very exclusive group of transition-metal complexes that enable imaging beyond the diffraction limit. Triplet excited-state phosphorescence was also utilized to probe the O concentration at the mitochondria in vitro, using lifetime mapping techniques.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Irídio/química
Substâncias Luminescentes/química
Mitocôndrias/ultraestrutura
Oxigênio/análise
[Mh] Termos MeSH secundário: Células HeLa
Seres Humanos
Microscopia Confocal/métodos
Microscopia Eletrônica de Transmissão/métodos
Mitocôndrias/química
Imagem Óptica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Luminescent Agents); 44448S9773 (Iridium); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b02633


  4 / 2399 MEDLINE  
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[PMID]:29231930
[Au] Autor:Jing Y; Cao Q; Hao L; Yang GG; Hu WL; Ji LN; Mao ZW
[Ad] Endereço:MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn caoqian3@mail.sysu.edu.cn.
[Ti] Título:A self-assessed photosensitizer: inducing and dual-modal phosphorescence imaging of mitochondria oxidative stress.
[So] Source:Chem Commun (Camb);54(3):271-274, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two novel Ir(iii)-nitroxide conjugates have been synthesized as mitochondria-targeted multi-functional theranostic photosensitizers, capable of simultaneously inducing and dual-modal phosphorescence imaging of mitochondrial oxidative stress under two-photon excitation, thus realizing the photodynamic therapy of cancer and self-assessment of their PDT efficacies.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Complexos de Coordenação/farmacologia
Óxidos N-Cíclicos/farmacologia
Irídio/química
Substâncias Luminescentes/farmacologia
Mitocôndrias/metabolismo
Estresse Oxidativo
Fármacos Fotossensibilizantes/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Complexos de Coordenação/química
Óxidos N-Cíclicos/química
Seres Humanos
Peróxido de Hidrogênio/farmacologia
Luz
Substâncias Luminescentes/química
Mitocôndrias/ultraestrutura
Fármacos Fotossensibilizantes/química
Acetato de Tetradecanoilforbol/farmacologia
Nanomedicina Teranóstica
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Cyclic N-Oxides); 0 (Luminescent Agents); 0 (Photosensitizing Agents); 44448S9773 (Iridium); BBX060AN9V (Hydrogen Peroxide); NI40JAQ945 (Tetradecanoylphorbol Acetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc07797a


  5 / 2399 MEDLINE  
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[PMID]:28467681
[Au] Autor:Ma DL; Dong ZZ; Vellaisamy K; Cheung KM; Yang G; Leung CH
[Ad] Endereço:Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
[Ti] Título:Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing.
[So] Source:Chem Rec;17(11):1135-1145, 2017 11.
[Is] ISSN:1528-0691
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:By catalyzing highly specific and tightly controlled chemical reactions, enzymes are essential to maintaining normal cellular physiology. However, aberrant enzymatic activity can be linked to the pathogenesis of various diseases. Therefore, the unusual activity of particular enzymes can represent testable biomarkers for the diagnosis or screening of certain diseases. In recent years, G-quadruplex-based platforms have attracted wide attention for the monitoring of enzymatic activities. In this Personal Account, we discuss our group's works on the development of G-quadruplex-based sensing system for enzyme activities by using mainly iridium(III) complexes as luminescent label-free probes. These studies showcase the versatility of the G-quadruplex for developing assays for a variety of different enzymes.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Ensaios Enzimáticos/métodos
Quadruplex G
Irídio/química
Substâncias Luminescentes/química
Medições Luminescentes/métodos
[Mh] Termos MeSH secundário: Animais
Técnicas Biossensoriais/métodos
Enzimas Reparadoras do DNA/análise
Enzimas Reparadoras do DNA/metabolismo
DNA Polimerase Dirigida por DNA/análise
DNA Polimerase Dirigida por DNA/metabolismo
Endonucleases/análise
Endonucleases/metabolismo
Exonucleases/análise
Exonucleases/metabolismo
Seres Humanos
Peptídeo Hidrolases/análise
Peptídeo Hidrolases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Luminescent Agents); 44448S9773 (Iridium); EC 2.7.7.7 (DNA-Directed DNA Polymerase); EC 3.1.- (Endonucleases); EC 3.1.- (Exonucleases); EC 3.4.- (Peptide Hydrolases); EC 6.5.1.- (DNA Repair Enzymes)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1002/tcr.201700014


  6 / 2399 MEDLINE  
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[PMID]:28759448
[Au] Autor:Gao J; Yan J; Liu Y; Zhang J; Guo Z
[Ad] Endereço:Research Center of Shanxi Province for High Gravity Chemical Engineering and Technology, North University of China, Taiyuan 030051, Shanxi Province, China E-mail: zbgaojing@163.com.
[Ti] Título:A novel electro-catalytic degradation method of phenol wastewater with Ti/IrO -Ta O anodes in high-gravity fields.
[So] Source:Water Sci Technol;76(3-4):662-670, 2017 Jul.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the electro-catalytic degradation process of phenol wastewater, bubbles and mass transfer limitation will result in the decrease in wastewater degradation efficiency, a long electrolysis time and a high energy consumption. Self-made Ti/IrO -Ta O anodes and a high-gravity electro-catalytic reactor were used to improve them. The Ti/IrO -Ta O anode was prepared with a thermal decomposition method and characterized by scanning electron microscopy (SEM). Under optimum conditions, the removal efficiencies of phenol, total organic carbon (TOC) and chemical oxygen demand (COD) respectively reached 94.77%, 50.96% and 41.2% after 2 h electrolysis in the high-gravity field, which were respectively 10.93%, 16.72% and 24.84% higher than those in the normal gravity field. For about the same removal efficiencies, the electrolysis time and energy consumed in the high-gravity field were 33.3% and 15.4% lower than those consumed in the normal gravity field, respectively. The degradation pathway of phenol detected by high performance liquid chromatography (HPLC) was unchanged in the high-gravity field, but the degradation rate of phenol increased. The Ti/IrO -Ta O anode provided good stability because the removal efficiencies of phenol and TOC decreased slightly and the surface morphology of the coating was almost unchanged when it had been used in electrolysis for 11 months, about 1,200 h, in the high-gravity field. Results indicated that the phenol wastewater degradation efficiency was improved, the time was shortened, and the energy consumption was reduced in the high-gravity field.
[Mh] Termos MeSH primário: Eletroquímica/métodos
Óxidos/química
Fenol/química
Tantálio/química
Titânio/química
Águas Residuais
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Catálise
Eletroquímica/instrumentação
Eletrodos
Eletrólise
Irídio/química
Fenóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxides); 0 (Phenols); 0 (Waste Water); 0 (Water Pollutants, Chemical); 12030-49-8 (iridium oxide); 339NCG44TV (Phenol); 44448S9773 (Iridium); 6424HBN274 (Tantalum); D1JT611TNE (Titanium); OEZ64Z53M4 (tantalum oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2017.262


  7 / 2399 MEDLINE  
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[PMID]:28686334
[Au] Autor:Liu S; Dutta S; Zheng W; Gould NS; Cheng Z; Xu B; Saha B; Vlachos DG
[Ad] Endereço:Catalysis Center for Energy Innovation, Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, 19716, USA.
[Ti] Título:Catalytic Hydrodeoxygenation of High Carbon Furylmethanes to Renewable Jet-fuel Ranged Alkanes over a Rhenium-Modified Iridium Catalyst.
[So] Source:ChemSusChem;10(16):3225-3234, 2017 Aug 24.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Renewable jet-fuel-range alkanes are synthesized by hydrodeoxygenation of lignocellulose-derived high-carbon furylmethanes over ReO -modified Ir/SiO catalysts under mild reaction conditions. Ir-ReO /SiO with a Re/Ir molar ratio of 2:1 exhibits the best performance, achieving a combined alkanes yield of 82-99 % from C -C furylmethanes. The catalyst can be regenerated in three consecutive cycles with only about 12 % loss in the combined alkanes yield. Mechanistically, the furan moieties of furylmethanes undergo simultaneous ring saturation and ring opening to form a mixture of complex oxygenates consisting of saturated furan rings, mono-keto groups, and mono-hydroxy groups. Then, these oxygenates undergo a cascade of hydrogenolysis reactions to alkanes. The high activity of Ir-ReO /SiO arises from a synergy between Ir and ReO , whereby the acidic sites of partially reduced ReO activate the C-O bonds of the saturated furans and alcoholic groups while the Ir sites are responsible for hydrogenation with H .
[Mh] Termos MeSH primário: Irídio/química
Metano/química
Oxigênio/química
Rênio/química
[Mh] Termos MeSH secundário: Catálise
Furanos/química
Hidrogênio/química
Hidrogenação
Pressão
Dióxido de Silício/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furans); 44448S9773 (Iridium); 7440-15-5 (Rhenium); 7631-86-9 (Silicon Dioxide); 7YNJ3PO35Z (Hydrogen); OP0UW79H66 (Methane); S88TT14065 (Oxygen); UC0XV6A8N9 (furan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700863


  8 / 2399 MEDLINE  
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[PMID]:28668477
[Au] Autor:Song XD; Kong X; He SF; Chen JX; Sun J; Chen BB; Zhao JW; Mao ZW
[Ad] Endereço:School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
[Ti] Título:Cyclometalated iridium(III)-guanidinium complexes as mitochondria-targeted anticancer agents.
[So] Source:Eur J Med Chem;138:246-254, 2017 Sep 29.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Guanidinium-functionalized molecules are commonly studied for their use as pharmaceutically active compounds and drugs carriers. Herein, four cyclometalated iridium(III) complexes containing guanidinium ligands have been synthesized and characterized as potential anticancer agents. These complexes exhibit moderate antitumor activity in HeLa, MCF-7, HepG2, CNE-2, and A549 human tumor cells. Interestingly, all complexes showed higher cytotoxicity than cisplatin against a cisplatin-resistant cell line A549R, and less cytotoxicity on the nontumorigenic LO2 cells. Intracellular distribution studies suggest that these complexes are selectively localized in the mitochondria. Mechanism studies indicate that these complexes arrested the cell cycle in the G0/G1 phase and can influence mitochondrial integrity, inducing cancer cell death through reactive oxygen species (ROS)-dependent pathways.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Guanidina/farmacologia
Irídio/farmacologia
Mitocôndrias/efeitos dos fármacos
Compostos Organometálicos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Guanidina/química
Seres Humanos
Irídio/química
Mitocôndrias/metabolismo
Estrutura Molecular
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Espécies Reativas de Oxigênio/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (Reactive Oxygen Species); 44448S9773 (Iridium); JU58VJ6Y3B (Guanidine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  9 / 2399 MEDLINE  
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[PMID]:28646657
[Au] Autor:Mou ZD; Deng N; Zhang F; Zhang J; Cen J; Zhang X
[Ad] Endereço:State Key Laboratory of Biotherapy and Department of Ophthalmology, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
[Ti] Título:"Half-sandwich" Schiff-base Ir(III) complexes as anticancer agents.
[So] Source:Eur J Med Chem;138:72-82, 2017 Sep 29.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of "half-sandwich" Schiff-base Ir(III) complexes were synthesized and investigated for their in vitro activities against the leukemia K562 cell line. These compounds demonstrated antiproliferative activities against K562 cells with IC values of 0.26-4.77 µM. In particular, compound 10c showed cytotoxicity against five cancer cell lines/sublines and stronger activities than cisplatin in K562, K562/A02, MCF-7, MCF-7/ADM, and A549 cells. Mechanism studies illustrated that compound 10c increased the level of reactive oxygen species and induced apoptosis of K562 cells. This compound effectively decreased the mitochondrial membrane potential and the protein level of Bcl-2. It also increased the protein levels of Bax, caspase-3, and caspase-9, and led to release of cytochrome c in K562 cells, indicating that the apoptosis induced by compound 10c was mediated by the intrinsic mitochondria apoptosis pathway.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Irídio/farmacologia
Compostos Organometálicos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Irídio/química
Estrutura Molecular
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Bases de Schiff/química
Bases de Schiff/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (Schiff Bases); 44448S9773 (Iridium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE


  10 / 2399 MEDLINE  
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[PMID]:28612494
[Au] Autor:Tong H; Jiang Y; Zhang Q; Li J; Jiang W; Zhang D; Li N; Xia L
[Ad] Endereço:College of Chemistry, Liaoning University, Shenyang, 110036, P.R. China.
[Ti] Título:Enhanced Interfacial Charge Transfer on a Tungsten Trioxide Photoanode with Immobilized Molecular Iridium Catalyst.
[So] Source:ChemSusChem;10(16):3268-3275, 2017 Aug 24.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The rational design of active photoanodes for photoelectrochemical (PEC) water splitting is crucial for future applications in sustainable energy conversion. A combination of catalysts with photoelectrodes is generally required to improve surface kinetics and suppress surface recombination. In this study, we present WO photoanode modified with the iridium complex [(H dphbpy)Ir (Cp*)Cl]Cl (Ir-PO H ; H dphbpy=2,2'-bipyridine-4,4'-bisphosphonic acid, Cp*=pentamethylcyclopentadiene (WO +Ir-PO H )- for PEC water oxidation. When Ir-PO H is anchored to a WO electrode, the photoanode shows a significant improvement in both photocurrent and faradaic efficiency compared to the bare WO photoanode. Under simulated sunlight illumination (AM 1.5G, 100 mW cm ) with an applied bias of 1.23 V (vs. reversible hydrogen electrode), the photoanode exhibits a photocurrent of 1.16 mA cm in acidic conditions, which is double that of the bare WO photoanode. The faradaic efficiency is promoted from 56 % to 95 %. Kinetic studies reveal that Ir-PO H exhibits a different interfacial charge-transfer mechanism on the WO photoanode for PEC water oxidation compared to iridium oxide. Ir-PO H , as a water-oxidation catalyst, can accelerate the surface charge transfer through rapid surface kinetics.
[Mh] Termos MeSH primário: Irídio/química
Óxidos/química
Processos Fotoquímicos
Tungstênio/química
[Mh] Termos MeSH secundário: Catálise
Eletrodos
Transporte de Elétrons
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxides); 44448S9773 (Iridium); 940E10M08M (tungsten oxide); V9306CXO6G (Tungsten)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700721



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