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Pesquisa : D01.268.556.412.500.498 [Categoria DeCS]
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[PMID]:28683078
[Au] Autor:Turker MS; Grygoryev D; Lasarev M; Ohlrich A; Rwatambuga FA; Johnson S; Dan C; Eckelmann B; Hryciw G; Mao JH; Snijders AM; Gauny S; Kronenberg A
[Ad] Endereço:Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, United States of America.
[Ti] Título:Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change.
[So] Source:PLoS One;12(7):e0180412, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to a small number of high-energy heavy charged particles (HZE ions), as found in the deep space environment, could significantly affect astronaut health following prolonged periods of space travel if these ions induce mutations and related cancers. In this study, we used an in vivo mutagenesis assay to define the mutagenic effects of accelerated 56Fe ions (1 GeV/amu, 151 keV/µm) in the mouse kidney epithelium exposed to doses ranging from 0.25 to 2.0 Gy. These doses represent fluences ranging from 1 to 8 particle traversals per cell nucleus. The Aprt locus, located on chromosome 8, was used to select induced and spontaneous mutants. To fully define the mutagenic effects, we used multiple endpoints including mutant frequencies, mutation spectrum for chromosome 8, translocations involving chromosome 8, and mutations affecting non-selected chromosomes. The results demonstrate mutagenic effects that often affect multiple chromosomes for all Fe ion doses tested. For comparison with the most abundant sparsely ionizing particle found in space, we also examined the mutagenic effects of high-energy protons (1 GeV, 0.24 keV/µm) at 0.5 and 1.0 Gy. Similar doses of protons were not as mutagenic as Fe ions for many assays, though genomic effects were detected in Aprt mutants at these doses. Considered as a whole, the data demonstrate that Fe ions are highly mutagenic at the low doses and fluences of relevance to human spaceflight, and that cells with considerable genomic mutations are readily induced by these exposures and persist in the kidney epithelium. The level of genomic change produced by low fluence exposure to heavy ions is reminiscent of the extensive rearrangements seen in tumor genomes suggesting a potential initiation step in radiation carcinogenesis.
[Mh] Termos MeSH primário: Cromossomos/efeitos da radiação
Epitélio/efeitos da radiação
Radioisótopos de Ferro/efeitos adversos
Rim/efeitos da radiação
Fótons/efeitos adversos
Translocação Genética/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Carcinogênese/efeitos da radiação
Cromossomos/química
Radiação Cósmica/efeitos adversos
Feminino
Loci Gênicos/efeitos da radiação
Íons Pesados
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
Simulação de Ambiente Espacial
Técnicas de Cultura de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iron Radioisotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180412


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[PMID]:28615450
[Au] Autor:Upadhyay AS; Stehling O; Panayiotou C; Rösser R; Lill R; Överby AK
[Ad] Endereço:From the Department of Clinical Microbiology, Virology, Umeå University, 90185 Umeå, Sweden.
[Ti] Título:Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.
[So] Source:J Biol Chem;292(33):13879-13889, 2017 Aug 18.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Viperin (RSAD2) is an interferon-stimulated antiviral protein that belongs to the radical -adenosylmethionine (SAM) enzyme family. Viperin's iron-sulfur (Fe/S) cluster is critical for its antiviral activity against many different viruses. CIA1 (CIAO1), an essential component of the cytosolic iron-sulfur protein assembly (CIA) machinery, is crucial for Fe/S cluster insertion into viperin and hence for viperin's antiviral activity. In the CIA pathway, CIA1 cooperates with CIA2A, CIA2B, and MMS19 targeting factors to form various complexes that mediate the dedicated maturation of specific Fe/S recipient proteins. To date, however, the mechanisms of how viperin acquires its radical SAM Fe/S cluster to gain antiviral activity are poorly understood. Using co-immunoprecipitation and Fe-radiolabeling experiments, we therefore studied the roles of CIA2A, CIA2B, and MMS19 for Fe/S cluster insertion. CIA2B and MMS19 physically interacted with the C terminus of viperin and used CIA1 as the primary viperin-interacting protein. In contrast, CIA2A bound to viperin's N terminus in a CIA1-, CIA2B-, and MMS19-independent fashion. Of note, the observed interaction of both CIA2 isoforms with a single Fe/S target protein is unprecedented in the CIA pathway. Fe-radiolabeling experiments with human cells depleted of CIA1, CIA2A, CIA2B, or MMS19 revealed that CIA1, but none of the other CIA factors, is predominantly required for Fe/S cluster incorporation into viperin. Collectively, viperin maturation represents a novel CIA pathway with a minimal requirement of the CIA-targeting factors and represents a new paradigm for the insertion of the Fe/S cofactor into a radical SAM protein.
[Mh] Termos MeSH primário: Proteínas de Transporte/metabolismo
Proteínas com Ferro-Enxofre/metabolismo
Metalochaperonas/metabolismo
Modelos Biológicos
Proteínas Nucleares/metabolismo
Proteínas/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Apoproteínas/química
Apoproteínas/genética
Apoproteínas/metabolismo
Proteínas de Transporte/antagonistas & inibidores
Proteínas de Transporte/química
Proteínas de Transporte/genética
Células HEK293
Seres Humanos
Imunoprecipitação
Ferro/química
Ferro/metabolismo
Radioisótopos de Ferro
Proteínas com Ferro-Enxofre/química
Proteínas com Ferro-Enxofre/genética
Metalochaperonas/antagonistas & inibidores
Metalochaperonas/química
Metalochaperonas/genética
Mutação
Proteínas Nucleares/antagonistas & inibidores
Proteínas Nucleares/química
Proteínas Nucleares/genética
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/genética
Fragmentos de Peptídeos/metabolismo
Domínios e Motivos de Interação entre Proteínas
Proteínas/química
Proteínas/genética
Interferência de RNA
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Fatores de Transcrição/antagonistas & inibidores
Fatores de Transcrição/química
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apoproteins); 0 (CIAO1 protein, human); 0 (Carrier Proteins); 0 (FAM96B protein, human); 0 (Fam96a protein, human); 0 (Iron Radioisotopes); 0 (Iron-Sulfur Proteins); 0 (MMS19 protein, human); 0 (Metallochaperones); 0 (Nuclear Proteins); 0 (Peptide Fragments); 0 (Proteins); 0 (RSAD2 protein, human); 0 (Recombinant Fusion Proteins); 0 (Recombinant Proteins); 0 (Transcription Factors); E1UOL152H7 (Iron)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.780122


  3 / 1699 MEDLINE  
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[PMID]:28031282
[Au] Autor:Balhesteros H; Shipelskiy Y; Long NJ; Majumdar A; Katz BB; Santos NM; Leaden L; Newton SM; Marques MV; Klebba PE
[Ad] Endereço:Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil.
[Ti] Título:TonB-Dependent Heme/Hemoglobin Utilization by Caulobacter crescentus HutA.
[So] Source:J Bacteriol;199(6), 2017 Mar 15.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Siderophore nutrition tests with strain NA1000 revealed that it utilized a variety of ferric hydroxamate siderophores, including asperchromes, ferrichromes, ferrichrome A, malonichrome, and ferric aerobactin, as well as hemin and hemoglobin. did not transport ferrioxamine B or ferric catecholates. Because it did not use ferric enterobactin, the catecholate aposiderophore was an effective agent for iron deprivation. We determined the kinetics and thermodynamics of [ Fe]apoferrichrome and Fe-citrate binding and transport by NA1000. Its affinity and uptake rate for ferrichrome (equilibrium dissociation constant [ ], 1 nM; Michaelis-Menten constant [ ], 0.1 nM; , 19 pMol/10 cells/min) were similar to those of FhuA. Transport properties for Fe-citrate were similar to those of FecA ( , 5.3 nM; , 29 pMol/10 cells/min). Bioinformatic analyses implicated Fur-regulated loci , , , and as TonB-dependent transporters (TBDT) that participate in iron acquisition. We resolved TBDT with elevated expression under high- or low-iron conditions by SDS-PAGE of sodium sarcosinate cell envelope extracts, excised bands of interest, and analyzed them by mass spectrometry. These data identified five TBDT: three were overexpressed during iron deficiency (00028, 02277, and 03023), and 2 were overexpressed during iron repletion (00210 and 01196). CLUSTALW analyses revealed homology of putative TBDT 02277 to FepA and BtuB. A Δ mutant did not transport hemin or hemoglobin in nutrition tests, leading us to designate the structural gene as (for eme/hemoglobin tilization). The physiological roles of the 62 putative TBDT of are mostly unknown, as are their evolutionary relationships to TBDT of other bacteria. We biochemically studied the iron uptake systems of , identified potential iron transporters, and clarified the phylogenetic relationships among its numerous TBDT. Our findings identified the first outer membrane protein involved in iron acquisition by , its heme/hemoglobin transporter (HutA).
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Caulobacter crescentus/metabolismo
Heme/metabolismo
Hemoglobinas/metabolismo
Proteínas de Membrana/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Transporte Biológico/fisiologia
Proteínas de Transporte/genética
Proteínas de Transporte/metabolismo
Caulobacter crescentus/genética
Regulação Bacteriana da Expressão Gênica/fisiologia
Ferro/metabolismo
Radioisótopos de Ferro
Proteínas de Membrana/genética
Sideróforos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Carrier Proteins); 0 (Hemoglobins); 0 (Iron Radioisotopes); 0 (Membrane Proteins); 0 (Siderophores); 0 (tonB protein, Bacteria); 42VZT0U6YR (Heme); E1UOL152H7 (Iron)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE


  4 / 1699 MEDLINE  
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[PMID]:27357483
[Au] Autor:Chekli L; Brunetti G; Marzouk ER; Maoz-Shen A; Smith E; Naidu R; Shon HK; Lombi E; Donner E
[Ad] Endereço:School of Civil and Environmental Engineering, University of Technology, Sydney, Post Box 129, Broadway, NSW 2007, Australia; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, ATC Building, University of Newcastle, Callaghan, NSW 2308, Australia.
[Ti] Título:Evaluating the mobility of polymer-stabilised zero-valent iron nanoparticles and their potential to co-transport contaminants in intact soil cores.
[So] Source:Environ Pollut;216:636-45, 2016 Sep.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of zero-valent iron nanoparticles (nZVI) has been advocated for the remediation of both soils and groundwater. A key parameter affecting nZVI remediation efficacy is the mobility of the particles as this influences the reaction zone where remediation can occur. However, by engineering nZVI particles with increased stability and mobility we may also inadvertently facilitate nZVI-mediated contaminant transport away from the zone of treatment. Previous nZVI mobility studies have often been limited to model systems as the presence of background Fe makes detection and tracking of nZVI in real systems difficult. We overcame this problem by synthesising Fe-59 radiolabelled nZVI. This enabled us to detect and quantify the leaching of nZVI-derived Fe-59 in intact soil cores, including a soil contaminated by Chromated-Copper-Arsenate. Mobility of a commercially available nZVI was also tested. The results showed limited mobility of both nanomaterials; <1% of the injected mass was eluted from the columns and most of the radiolabelled nZVI remained in the surface soil layers (the primary treatment zone in this contaminated soil). Nevertheless, the observed breakthrough of contaminants and nZVI occurred simultaneously, indicating that although the quantity transported was low in this case, nZVI does have the potential to co-transport contaminants. These results show that direct injection of nZVI into the surface layers of contaminated soils may be a viable remediation option for soils such as this one, in which the mobility of nZVI below the injection/remediation zone was very limited. This Fe-59 experimental approach can be further extended to test nZVI transport in a wider range of contaminated soil types and textures and using different application methods and rates. The resulting database could then be used to develop and validate modelling of nZVI-facilitated contaminant transport on an individual soil basis suitable for site specific risk assessment prior to nZVI remediation.
[Mh] Termos MeSH primário: Arseniatos/química
Ferro/química
Nanopartículas Metálicas/química
Poluentes do Solo/química
[Mh] Termos MeSH secundário: Recuperação e Remediação Ambiental
Radioisótopos de Ferro/análise
Polímeros
Solo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Iron Radioisotopes); 0 (Polymers); 0 (Soil); 0 (Soil Pollutants); 37337-13-6 (chromated copper arsenate); E1UOL152H7 (Iron)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE


  5 / 1699 MEDLINE  
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[PMID]:27259810
[Au] Autor:Zhao Q; Mao A; Yan J; Si J; Zhou R; Gan L; Liu Y; Zhang H
[Ad] Endereço:Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China; Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, PR China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, PR China; University of Chine
[Ti] Título:(56)Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis.
[So] Source:Life Sci;157:32-7, 2016 Jul 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews during and after missions. Since the testis is a radiosensitive organ, which may be susceptible to space radiation-induced changes. In this study, we investigated the effect and potential mechanisms of (56)Fe irradiation on mouse testis. Pathological characteristics were measured following whole-body irradiation with 0.5 and 1Gy (56)Fe irradiation. Flow cytometry and terminal dUTP nick end-labeling (TUNEL) were performed to detect apoptotic cells. Western blot was applied to identify potential biomarkers. Immunofluorescence was used to investigate protein localization. We found that pathologic changes and apoptosis cells were significantly higher in 1Gy group than those in 0Gy groups. In addition, protein expression and localization studies confirmed Nrf2 was involved in this acute injury. Nrf2 and its target genes HO-1 and NQO1 were up-regulated in the irradiated testis in a dose-dependent manner. Nrf2 may be useful molecular markers in radiation-induced cellular responses and is important for detecting abnormal spermatogenesis following exposure to space radiation.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Radioisótopos de Ferro/farmacologia
Fator 2 Relacionado a NF-E2/metabolismo
Testículo/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Caspases/metabolismo
Radiação Cósmica
Ativação Enzimática
Marcação In Situ das Extremidades Cortadas
Masculino
Camundongos
Testículo/metabolismo
Testículo/patologia
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iron Radioisotopes); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (bcl-2-Associated X Protein); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  6 / 1699 MEDLINE  
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[PMID]:27237589
[Au] Autor:Wyrobek AJ; Britten RA
[Ad] Endereço:Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California.
[Ti] Título:Individual variations in dose response for spatial memory learning among outbred wistar rats exposed from 5 to 20 cGy of (56) Fe particles.
[So] Source:Environ Mol Mutagen;57(5):331-40, 2016 Jun.
[Is] ISSN:1098-2280
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposures of brain tissue to ionizing radiation can lead to persistent deficits in cognitive functions and behaviors. However, little is known about the quantitative relationships between exposure dose and neurological risks, especially for lower doses and among genetically diverse individuals. We investigated the dose relationship for spatial memory learning among genetically outbred male Wistar rats exposed to graded doses of (56) Fe particles (sham, 5, 10, 15, and 20 cGy; 1 GeV/n). Spatial memory learning was assessed on a Barnes maze using REL3 ratios measured at three months after exposure. Irradiated animals showed dose-dependent declines in spatial memory learning that were fit by a linear regression (P for slope <0.0002). The irradiated animals showed significantly impaired learning at 10 cGy exposures, no detectable learning between 10 and 15 cGy, and worsened performances between 15 and 20 cGy. The proportions of poor learners and the magnitude of their impairment were fit by linear regressions with doubling doses of ∼10 cGy. In contrast, there were no detectable deficits in learning among the good learners in this dose range. Our findings suggest that genetically diverse individuals can vary substantially in their spatial memory learning, and that exposures at low doses appear to preferentially impact poor learners. This hypothesis invites future investigations of the genetic and physiological mechanisms of inter-individual variations in brain function related to spatial memory learning after low-dose HZE radiation exposures and to determine whether it also applies to physical trauma to brain tissue and exposures to chemical neurotoxicants. Environ. Mol. Mutagen. 57:331-340, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos da radiação
Radiação Cósmica
Aprendizagem em Labirinto/efeitos da radiação
Memória Espacial/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Encéfalo/fisiopatologia
Encéfalo/efeitos da radiação
Relação Dose-Resposta à Radiação
Radioisótopos de Ferro
Modelos Lineares
Masculino
Dose de Radiação
Ratos Wistar
Irradiação Corporal Total
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iron Radioisotopes)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160531
[St] Status:MEDLINE
[do] DOI:10.1002/em.22018


  7 / 1699 MEDLINE  
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[PMID]:27078562
[Au] Autor:Melott AL
[Ad] Endereço:Department of Physics and Astronomy, University of Kansas, Lawrence, Kansas 66045, USA.
[Ti] Título:Stellar astrophysics: Supernovae in the neighbourhood.
[So] Source:Nature;532(7597):40-1, 2016 Apr 07.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Evolução Biológica
Terra (Planeta)
Radioisótopos de Ferro/análise
Astros Celestes/química
[Mh] Termos MeSH secundário: Animais
Mudança Climática/história
Extinção Biológica
Sedimentos Geológicos/química
História Antiga
Seres Humanos
Radioisótopos de Ferro/química
Fatores de Tempo
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iron Radioisotopes)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1038/532040a


  8 / 1699 MEDLINE  
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[PMID]:27038212
[Au] Autor:Huang B; Xiao L; Yang LY; Ji R; Miao AJ
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu Province, 210023, China.
[Ti] Título:Facile synthesis of (55)Fe-labeled well-dispersible hematite nanoparticles for bioaccumulation studies in nanotoxicology.
[So] Source:Environ Pollut;213:801-808, 2016 Jun.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although water-dispersible engineered nanoparticles (ENPs) have a wide range of applications, the ENPs used in many nanotoxicological studies tend to form micron-sized aggregates in the exposure media and thus cannot reflect the toxicity of real nanoparticles. Here we described the synthesis of bare hematite nanoparticles (HNPs-0) and two poly(acrylic acid) (PAA)-coated forms (HNPs-1 and HNPs-2). All three HNPs were well dispersed in deionized water, but HNPs-0 quickly aggregated in the three culture media tested. By contrast, the suspensions of HNPs-1 and HNPs-2 remained stable, with negligible amounts of PAA and Fe(3+) liberated from either one under the investigated conditions. To better quantify the accumulation of the coated HNPs, a relatively innocuous (55)Fe-labeled form of HNPs-2 was synthesized as an example and its accumulation in three phytoplankton species was tested. Consistent with the uptake kinetics model for conventional pollutants, the cellular accumulation of HNPs-2 increased linearly with exposure time for two of the three phytoplankton species. These results demonstrate the utility of (55)Fe-labeled well-dispersible HNPs as a model material for nanoparticle bioaccumulation studies in nanotoxicology.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Compostos Férricos/toxicidade
Nanopartículas/toxicidade
Nanotecnologia/métodos
Fitoplâncton/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Fenômenos Químicos
Compostos Férricos/química
Compostos Férricos/metabolismo
Radioisótopos de Ferro
Cinética
Modelos Teóricos
Nanopartículas/química
Nanopartículas/metabolismo
Tamanho da Partícula
Fitoplâncton/metabolismo
Testes de Toxicidade
Poluentes Químicos da Água/química
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Ferric Compounds); 0 (Iron Radioisotopes); 0 (Water Pollutants, Chemical); 1K09F3G675 (ferric oxide); 4Q93RCW27E (carbopol 940)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160403
[St] Status:MEDLINE


  9 / 1699 MEDLINE  
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[PMID]:26688358
[Au] Autor:Luca A
[Ad] Endereço:Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, IFIN-HH Bucharest, 30 Reactorului Street, PO Box MG-6, Magurele, Ilfov County, RO-077125, Romania. Electronic address: aluca@nipne.ro.
[Ti] Título:Decay Data Evaluation Project: Evaluation of (52)Fe nuclear decay data.
[So] Source:Appl Radiat Isot;109:169-171, 2016 Mar.
[Is] ISSN:1872-9800
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Within the Decay Data Evaluation Project (DDEP) and the IAEA Coordinated Research Project no. F41029, the evaluation of the nuclear decay data of (52)Fe, a radionuclide of interest in nuclear medicine, was performed. The main nuclear decay data evaluated are: the half-life, decay energy, energies and probabilities of the electron capture and ß(+) transitions, internal conversion coefficients and gamma-ray energies and emission intensities. This new evaluation, made using the DDEP methodology and tools, was included in the DDEP database NUCLEIDE.
[Mh] Termos MeSH primário: Radioisótopos de Ferro/análise
Radioisótopos de Ferro/química
Radiometria/métodos
Radiometria/normas
[Mh] Termos MeSH secundário: Meia-Vida
Radioisótopos de Ferro/normas
Valores de Referência
Reprodutibilidade dos Testes
Romênia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iron Radioisotopes)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


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[PMID]:26408534
[Au] Autor:Coleman MA; Sasi SP; Onufrak J; Natarajan M; Manickam K; Schwab J; Muralidharan S; Peterson LE; Alekseyev YO; Yan X; Goukassian DA
[Ad] Endereço:University of California, Davis School of Medicine, Radiation Oncology, Sacramento, California; Lawrence Livermore National Laboratory, Livermore, California;
[Ti] Título:Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes.
[So] Source:Am J Physiol Heart Circ Physiol;309(11):H1947-63, 2015 Dec 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There are 160,000 cancer patients worldwide treated with particle radiotherapy (RT). With the advent of proton, and high (H) charge (Z) and energy (E) HZE ionizing particle RT, the cardiovascular diseases risk estimates are uncertain. In addition, future deep space exploratory-type missions will expose humans to unknown but low doses of particle irradiation (IR). We examined molecular responses using transcriptome profiling in left ventricular murine cardiomyocytes isolated from mice that were exposed to 90 cGy, 1 GeV proton ((1)H) and 15 cGy, 1 GeV/nucleon iron ((56)Fe) over 28 days after exposure. Unsupervised clustering analysis of gene expression segregated samples according to the IR response and time after exposure, with (56)Fe-IR showing the greatest level of gene modulation. (1)H-IR showed little differential transcript modulation. Network analysis categorized the major differentially expressed genes into cell cycle, oxidative responses, and transcriptional regulation functional groups. Transcriptional networks identified key nodes regulating expression. Validation of the signal transduction network by protein analysis and gel shift assay showed that particle IR clearly regulates a long-lived signaling mechanism for ERK1/2, p38 MAPK signaling and identified NFATc4, GATA4, STAT3, and NF-κB as regulators of the response at specific time points. These data suggest that the molecular responses and gene expression to (56)Fe-IR in cardiomyocytes are unique and long-lasting. Our study may have significant implications for the efforts of National Aeronautics and Space Administration to develop heart disease risk estimates for astronauts and for patients receiving conventional and particle RT via identification of specific HZE-IR molecular markers.
[Mh] Termos MeSH primário: Redes Reguladoras de Genes/efeitos da radiação
Radioisótopos de Ferro/toxicidade
Miócitos Cardíacos/efeitos da radiação
Radioterapia de Alta Energia/efeitos adversos
Transdução de Sinais/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Análise por Conglomerados
Ativação Enzimática
Fibrose
Fator de Transcrição GATA4/genética
Fator de Transcrição GATA4/metabolismo
Perfilação da Expressão Gênica/métodos
Regulação da Expressão Gênica/efeitos da radiação
Masculino
Camundongos Endogâmicos C57BL
Proteínas Quinases Ativadas por Mitógeno/genética
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/patologia
Análise de Sequência com Séries de Oligonucleotídeos
Reação em Cadeia da Polimerase em Tempo Real
Medição de Risco
Fator de Transcrição STAT3/genética
Fator de Transcrição STAT3/metabolismo
Fatores de Tempo
Transcrição Genética/efeitos da radiação
Transcriptoma/efeitos da radiação
Irradiação Corporal Total
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (GATA4 Transcription Factor); 0 (Gata4 protein, mouse); 0 (Iron Radioisotopes); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, mouse); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150927
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00050.2015



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