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  1 / 8253 MEDLINE  
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[PMID]:29231017
[Au] Autor:Wang YL; Sheng X; Li M; Chen YL; Lin Y; Chen LQ
[Ad] Endereço:Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot 010030, China.
[Ti] Título:[Forensic Application of HuaxiaTM Platinum Kit].
[So] Source:Fa Yi Xue Za Zhi;33(2):129-135, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To investigate the genetic polymorphism of 23 autosomal STR loci of Huaxia™ Platinum kit in Chinese Han population, and to evaluate the forensic efficiency of Huaxia™ Platinum kit. METHODS: A total of 500 unrelated healthy individuals from Han population were genotyped with Huaxia™ Platinum kit. The frequency distribution and the parameter of population genetics of STR loci were analysed statistically. Huaxia™ Platinum kit was compared with other 7 commercial STR kits commonly seen at home and abroad in the number of STR loci, interior label, fluorescent mark, total number of alleles in Ladder and system effectiveness. RESULTS: All the 23 autosomal STR loci were consistent with Hardy-Weinberg equilibrium ( >0.05). The discrimination power was 0.791 5-0.986 2. The polymorphism information content (PIC) was 0.559 0-0.914 0. The combined discrimination power (CDP) was 1-4.1×10⁻²8, while combined probability of paternity exclusion in trio (CPET) and in duo (CPED) were 1-4.1×10⁻¹° and 1-8.4×10⁻7, respectively. Compared with other 7 kits, Huaxia™ Platinum kit contained the most number of alleles within the Ladder. CONCLUSIONS: All the 23 autosomal STR loci of Huaxia™ Platinum kit with highly polymorphic in Han population can be used for paternity testing and individual identification. Compared with other 7 kits, it appears that Huaxia™ Platinum kit can provide more genetic information.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Genética Forense/métodos
Genética Populacional
Paternidade
Platina
Polimorfismo Genético
[Mh] Termos MeSH secundário: Alelos
Grupo com Ancestrais do Continente Asiático/etnologia
China
Frequência do Gene
Genótipo
Seres Humanos
Repetições de Microssatélites
Probabilidade
Kit de Reagentes para Diagnóstico
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reagent Kits, Diagnostic); 49DFR088MY (Platinum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.005


  2 / 8253 MEDLINE  
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[PMID]:29247929
[Au] Autor:Lee SL; Ho LN; Ong SA; Wong YS; Voon CH; Khalik WF; Yusoff NA; Nordin N
[Ad] Endereço:School of Materials Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia.
[Ti] Título:Role of dissolved oxygen on the degradation mechanism of Reactive Green 19 and electricity generation in photocatalytic fuel cell.
[So] Source:Chemosphere;194:675-681, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, a membraneless photocatalytic fuel cell with zinc oxide loaded carbon photoanode and platinum loaded carbon cathode was constructed to investigate the impact of dissolved oxygen on the mechanism of dye degradation and electricity generation of photocatalytic fuel cell. The photocatalytic fuel cell with high and low aeration rate, no aeration and nitrogen purged were investigated, respectively. The degradation rate of diazo dye Reactive Green 19 and the electricity generation was enhanced in photocatalytic fuel cell with higher dissolved oxygen concentration. However, the photocatalytic fuel cell was still able to perform 37% of decolorization in a slow rate (k = 0.033 h ) under extremely low dissolved oxygen concentration (approximately 0.2 mg L ) when nitrogen gas was introduced into the fuel cell throughout the 8 h. However, the change of the UV-Vis spectrum indicates that the intermediates of the dye could not be mineralized under insufficient dissolved oxygen level. In the aspect of electricity generation, the maximum short circuit current (0.0041 mA cm ) and power density (0.00028 mW cm ) of the air purged photocatalytic fuel cell was obviously higher than that with nitrogen purging (0.0015 mA cm and 0.00008 mW cm ).
[Mh] Termos MeSH primário: Compostos Azo/química
Eletricidade
Eletrólise/métodos
Oxigênio/química
[Mh] Termos MeSH secundário: Carbono
Catálise
Eletrodos
Processos Fotoquímicos
Platina
Óxido de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (reactive green 19); 49DFR088MY (Platinum); 7440-44-0 (Carbon); S88TT14065 (Oxygen); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  3 / 8253 MEDLINE  
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[PMID]:28448876
[Au] Autor:Sebesta F; Burda JV
[Ad] Endereço:Department of Chemical Physics and Optics, Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 121 16 Prague 2, Czech Republic.
[Ti] Título:Study on electronic properties, thermodynamic and kinetic parameters of the selected platinum(II) derivatives interacting with guanine.
[So] Source:J Inorg Biochem;172:100-109, 2017 Jul.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interaction of hydrated forms of several potential anticancer agents (PtCl (diaminocyclohexane), trans-[PtCl (NH )(thiazole)], cis-[PtCl (NH )(piperidine)], and cis-PtCl (NH )(cyclohexylamine) complexes) with guanine are explored and compared with an analogous interaction of cisplatin. Basic electronic properties, binding and stabilization energies are determined and energy profiles for the aquation reaction are estimated at the B3LYP/6-311++G(2df,2pd) level of theory. It is found that the substitution reaction is an exothermic and exergonic process with ΔG slightly less negative than -20kcal/mol. The largest energy release occurs for PtCl(H O)(diaminocyclohexane) complex. The rate constants for the Pt(II) complexes in the chloro- and hydroxo-form are compared and an impact of the ligand in the trans position to water is discussed.
[Mh] Termos MeSH primário: Fenômenos Eletromagnéticos
Guanina/química
Platina/química
Termodinâmica
[Mh] Termos MeSH secundário: Antineoplásicos/química
Cinética
Compostos Organoplatínicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organoplatinum Compounds); 49DFR088MY (Platinum); 5Z93L87A1R (Guanine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  4 / 8253 MEDLINE  
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[PMID]:29216566
[Au] Autor:Sahin Ö; Özdemir ÜÖ; Seferoglu N; Genc ZK; Kaya K; Aydiner B; Tekin S; Seferoglu Z
[Ad] Endereço:Department of Chemistry, Faculty of Science, Gazi University, Teknikokullar, Ankara 06500, Turkey.
[Ti] Título:New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies.
[So] Source:J Photochem Photobiol B;178:428-439, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L) ] and [Pt(L) ]), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules. The photophysical properties changes were observed after deprotonation of L with CN via intermolecular charge transfer (ICT). Additionally, as the sensor is a colorimetric and fluorimetric cyanide probe containing active sites such as coumarin-thiazole and imine (CH=N), it showed fast color change from yellow to deep red in the visible region, and yellow fluorescence after CN addition to the imine bond, in DMSO. The reaction mechanisms of L with CN , F and AcO ions were evaluated using H NMR shifts. The results showed that, the reaction of L with CN ion was due to the deprotonation and addition mechanisms at the same time. The anti-cancer activity of L and its Pd(II) and Pt(II) complexes were evaluated in vitro using MTT assay on the human cancer lines MCF-7 (human breast adenocarcinoma), LS174T (human colon carcinoma), and LNCAP (human prostate adenocarcinoma). The anti-cancer effects of L and its complexes, on human cells, were determined by comparing the half maximal inhibitory concentration (IC ) values. The activity results showed that, the Pd(II) complex of L has higher anti-tumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines.
[Mh] Termos MeSH primário: Complexos de Coordenação/síntese química
Paládio/química
Platina/química
Bases de Schiff/química
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Antineoplásicos/toxicidade
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Complexos de Coordenação/química
Complexos de Coordenação/toxicidade
Cumarínicos/química
Cristalografia por Raios X
Seres Humanos
Ligações de Hidrogênio
Células MCF-7
Espectroscopia de Ressonância Magnética
Magnetismo
Conformação Molecular
Teoria Quântica
Espectrofotometria Ultravioleta
Eletricidade Estática
Tiazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Coumarins); 0 (Schiff Bases); 0 (Thiazoles); 49DFR088MY (Platinum); 5TWQ1V240M (Palladium); A4VZ22K1WT (coumarin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  5 / 8253 MEDLINE  
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[PMID]:29369176
[Au] Autor:Wang Y; Ma X; Wei Y; Ma D; Gong P
[Ad] Endereço:Center of Cancer, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei.
[Ti] Título:Effect of platinum-based chemotherapy on EGFR gene mutation status in lung adenocarcinoma.
[So] Source:Medicine (Baltimore);97(4):e9602, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to detect the epidermal growth factor receptor (EGFR) gene type at pre- and postchemotherapy to evaluate the impact of platinum-based chemotherapy on EGFR gene mutations and provide a theoretical foundation for clinical treatment.Around 40 serum DNA samples were collected from advanced nonsmall cell lung cancer patients who received platinum-based chemotherapy as first-line treatment in our hospital from August 1, 2014 to June 1, 2015. The EGFR gene exons 19 and 21 were amplified by polymerase chain reaction (PCR) and detected by direct sequencing. The outcomes were analyzed with SPSS 17.0.Of 40 patients, 38 were included in the analysis. An EGFR gene mutation was detected in 17 cases (44.7%) at prechemotherapy compared with 19 cases (50.0%) at postchemotherapy. The EGFR gene mutation differences were not statistically significantly (P = .165) during pre- and postchemotherapy. The EGFR gene type was consistent in 26 cases (68.4%). Among the 12 discordant cases, 5 cases changed from mutant type to wild type, while 7 cases changed from wild type to mutant type. EGFR mutation positive patients had a disease control rate (DCR) of 88.2% (15/17), whereas it was only 57.1% in EGFR mutation negative patients, which was statistically significant (P = 0.01) indicating a better curative effect in EGFR mutation positive patients.Platinum-based chemotherapy may change the serum EGFR gene type in advanced lung adenocarcinoma.
[Mh] Termos MeSH primário: Adenocarcinoma/genética
Antineoplásicos/farmacologia
Neoplasias Pulmonares/genética
Mutação/efeitos dos fármacos
Platina/farmacologia
Receptor do Fator de Crescimento Epidérmico/efeitos dos fármacos
Receptor do Fator de Crescimento Epidérmico/genética
[Mh] Termos MeSH secundário: Adenocarcinoma/tratamento farmacológico
Idoso
Feminino
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Masculino
Meia-Idade
Receptor do Fator de Crescimento Epidérmico/sangue
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 49DFR088MY (Platinum); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009602


  6 / 8253 MEDLINE  
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[PMID]:29173770
[Au] Autor:Shen J; Ye Y; Chang DW; Huang M; Heymach JV; Roth JA; Wu X; Zhao H
[Ad] Endereço:Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
[Ti] Título:Circulating metabolite profiles to predict overall survival in advanced non-small cell lung cancer patients receiving first-line chemotherapy.
[So] Source:Lung Cancer;114:70-78, 2017 Dec.
[Is] ISSN:1872-8332
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The prognosis for advanced-stage non-small cell lung cancer (NSCLC) is usually poor. However, survival may be variable and difficult to predict. In the current study, we aimed to identify circulating metabolites as potential predictive biomarkers for overall survival of advanced-stage (III/IV) NSCLC patients treated with first-line platinum-based chemotherapy. MATERIALS AND METHODS: Using two-stage study design, we performed global metabolomic profiling in blood of 220 advanced-stage NSCLC patients, including 110 with poor survival and 110 with good survival. Metabolomic profiling was conducted using Metabolon platform. The association of each metabolite with survival was assessed by Cox proportional hazard regression model with adjustment for covariates. RESULTS AND CONCLUSION: We found levels of 4 metabolites, caffeine, paraxanthine, stachydrine, and methyl glucopyranoside (alpha+beta), differed significantly between NSCLC patients with poor and good survival in both discovery and validation phases (P<0.05). Interestingly, majority of the identified metabolites are involved in caffeine metabolism, and 2 metabolites are related to coffee intake. In fact, caffeine metabolism pathway was the only significant pathway identified which significantly differed between NSCLC patients with poor and good survival (P=1.48E-07) in the pathway analysis. We also found 4 metabolites whose levels were significantly associated with good survival in both discovery and validation phases. Strong cumulative effects on overall survival were observed for these 4 metabolites. In conclusion, we identified a panel of metabolites including metabolites in caffeine metabolism pathway that may predict survival outcome in advanced-stage NSCLC patients. The identified small metabolites may be useful biomarker candidates to help identify patients who may benefit from platinum-based chemotherapy.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/sangue
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Neoplasias Pulmonares/sangue
Neoplasias Pulmonares/tratamento farmacológico
Metabolômica/métodos
[Mh] Termos MeSH secundário: Idoso
Antineoplásicos/uso terapêutico
Biomarcadores Tumorais
Carcinoma Pulmonar de Células não Pequenas/patologia
Intervalo Livre de Doença
Feminino
Seres Humanos
Neoplasias Pulmonares/patologia
Masculino
Meia-Idade
Estadiamento de Neoplasias
Platina/administração & dosagem
Platina/uso terapêutico
Valor Preditivo dos Testes
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers, Tumor); 49DFR088MY (Platinum)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  7 / 8253 MEDLINE  
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[PMID]:28745634
[Au] Autor:Ma Z; Wu Z; Miller JT
[Ad] Endereço:Davidson School of Chemical Engineering, Purdue University.
[Ti] Título:Synthesis and Testing of Supported Pt-Cu Solid Solution Nanoparticle Catalysts for Propane Dehydrogenation.
[So] Source:J Vis Exp;(125), 2017 Jul 18.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A convenient method for the synthesis of bimetallic Pt-Cu catalysts and performance tests for propane dehydrogenation and characterization are demonstrated here. The catalyst forms a substitutional solid solution structure, with a small and uniform particle size around 2 nm. This is realized by careful control over the impregnation, calcination, and reduction steps during catalyst preparation and is identified by advanced in situ synchrotron techniques. The catalyst propane dehydrogenation performance continuously improves with increasing Cu:Pt atomic ratio.
[Mh] Termos MeSH primário: Cobre/química
Nanopartículas Metálicas/química
Platina/química
Propano/química
[Mh] Termos MeSH secundário: Catálise
Hidrogênio/química
Tamanho da Partícula
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
49DFR088MY (Platinum); 789U1901C5 (Copper); 7YNJ3PO35Z (Hydrogen); T75W9911L6 (Propane)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.3791/56040


  8 / 8253 MEDLINE  
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[PMID]:29235755
[Au] Autor:Shamelashvili KL; Shtemenko NI; Leus LV; Babiy SO; Shtemenko OV
[Ti] Título:Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system.
[So] Source:Ukr Biochem J;88(4):29-39, 2016 Jul-Aug.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Effects of the different modes of administration of dichlorotetra-µ-isobutyratodirhenium(ІІІ) ­ І ­ (in water solution, liposomes, nanoliposomes and together with cisplatin ­ in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocyte antioxidant enzymes were investigated on the model of tumor growth. A decrease in the concentration of TBA-active substances caused by dirhenium compounds was shown to be independent of the administration mode and the extent of the tumor growth inhibition. I was four-times more effective in inhibition of the LP burst than any known antioxidant. I induced the increasing activity of erythrocyte superoxide dismutase and decreasing activity of catalase. In vitro experiments with native superoxide dismutase, the interaction of І with following activation of the active center of the enzyme was confirmed and the superoxide dismutase activity of І was shown, that may contribute to the enhancement of the enzyme activity in vivo. The cluster rhenium compounds may be promising nontoxic potent antioxidants capable of deactivating superoxide radicals.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Antioxidantes/farmacologia
Carcinoma/tratamento farmacológico
Complexos de Coordenação/farmacologia
Platina/química
Rênio/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/síntese química
Antioxidantes/síntese química
Carcinoma/sangue
Carcinoma/metabolismo
Carcinoma/patologia
Catalase/sangue
Complexos de Coordenação/síntese química
Ativação Enzimática/efeitos dos fármacos
Eritrócitos/efeitos dos fármacos
Eritrócitos/enzimologia
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Lipossomos/administração & dosagem
Nanopartículas/administração & dosagem
Transplante de Neoplasias
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Wistar
Superóxido Dismutase/sangue
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Coordination Complexes); 0 (Liposomes); 0 (Thiobarbituric Acid Reactive Substances); 49DFR088MY (Platinum); 7440-15-5 (Rhenium); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.04.029


  9 / 8253 MEDLINE  
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[PMID]:29232581
[Au] Autor:Rahman FU; Bhatti MZ; Ali A; Duong HQ; Zhang Y; Yang B; Koppireddi S; Lin Y; Wang H; Li ZT; Zhang DW
[Ad] Endereço:Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China; Department of Materials Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
[Ti] Título:Homo- and heteroleptic Pt(II) complexes of ONN donor hydrazone and 4-picoline: A synthetic, structural and detailed mechanistic anticancer investigation.
[So] Source:Eur J Med Chem;143:1039-1052, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Two series of homoleptic Pt(II)(hydrazone)Cl (C1a-C5a) and heteroleptic Pt(II)(hydrazone)(4-picoline). BF (C1b-C5b) complexes were prepared and characterized by H, C, F NMR and HR ESI-MS. Structure of C2b was confirmed by single crystal X-ray analysis. These complexes were studied for their in vitro anticancer activities in human multiple cancer cells including breast (MCF-7), liver (HepG2), lung (H460), colon (HCT116) and cervical (Hela) cancers. C1a-C5a and C1b-C5b showed considerable anticancer effect. The overall anticancer effect of all these complexes was higher in liver (HepG2) and lung (H460) cancer cell lines and the effect of C2b and C3b was observed to be the highest among these 10 complexes. Therefore, we selected C2b and C3b to study their in vitro anticancer mechanism in HepG2 and H460 cancer cells. C2b and C3b changed cancer cell morphology and inhibited cell migration. The anticancer mechanistic studies demonstrated that C2b and C3b induced cell apoptosis, as evidenced by DAPI and AO/EB staining and flow cytometry analyses. Moreover, qRT-PCR and western blotting analysis showed that H460 and HepG2 cells treated with C2b and C3b significantly increased the expression of p53, p63, p21, p15, Bax and decreased Bcl-2 and c-Myc levels. The DNA binding property of these complexes was investigated by gel electrophoresis using pBR322 plasmid DNA. Taken together, the results obtained from the present study demonstrated the potentials of this new class of Pt(II) complexes in reduction of cell viability, suppression of cell migration and acceleration of apoptosis in different cancer cells.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Hidrazonas/farmacologia
Compostos Organoplatínicos/farmacologia
Picolinas/farmacologia
Platina/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Hidrazonas/química
Estrutura Molecular
Compostos Organoplatínicos/síntese química
Compostos Organoplatínicos/química
Picolinas/química
Platina/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Hydrazones); 0 (Organoplatinum Compounds); 0 (Picolines); 49DFR088MY (Platinum)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:28460361
[Au] Autor:Zivkovic MD; Rajkovic S; Glisic BD; Draskovic NS; Djuran MI
[Ad] Endereço:University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovica 12, 34000 Kragujevac, Serbia. Electronic address: mzivkovic@kg.ac.rs.
[Ti] Título:Hydrolysis of the amide bond in histidine- and methionine-containing dipeptides promoted by pyrazine and pyridazine palladium(II)-aqua dimers: Comparative study with platinum(II) analogues.
[So] Source:Bioorg Chem;72:190-198, 2017 06.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two dinuclear palladium(II) complexes, [{Pd(en)Cl} (µ-pz)](NO ) and [{Pd(en)Cl} (µ-pydz)](NO ) , have been synthesized and characterized by elemental microanalysis and spectroscopic ( H and C NMR, IR and UV-vis) techniques (en is ethylenediamine; pz is pyrazine and pydz is pyridazine). The square planar geometry of palladium(II) metal centers in these complexes has been predicted by DFT calculations. The chlorido complexes were converted into the corresponding aqua complexes, [{Pd(en)(H O)} (µ-pz)] and [{Pd(en)(H O)} (µ-pydz)] , and their reactions with N-acetylated l-histidylglycine (Ac-l-His-Gly) and l-methionylglycine (Ac-l-Met-Gly) were studied by H NMR spectroscopy. The palladium(II)-aqua complexes and dipeptides were reacted in 1:1 M ratio, and all reactions performed in the pH range 2.0
[Mh] Termos MeSH primário: Amidas/química
Dipeptídeos/química
Histidina/química
Metionina/química
Compostos Organometálicos/química
[Mh] Termos MeSH secundário: Dimerização
Relação Dose-Resposta a Droga
Hidrólise
Estrutura Molecular
Paládio/química
Platina/química
Pirazinas/química
Piridazinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Dipeptides); 0 (Organometallic Compounds); 0 (Pyrazines); 0 (Pyridazines); 49DFR088MY (Platinum); 4QD397987E (Histidine); 5TWQ1V240M (Palladium); AE28F7PNPL (Methionine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE



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