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  1 / 1850 MEDLINE  
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[PMID]:29172469
[Au] Autor:Luengo A; Fernández-Moreira V; Marzo I; Gimeno MC
[Ad] Endereço:Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea, CSIC-Universidad de Zaragoza , Pedro Cerbuna 12, 50009 Zaragoza, Spain.
[Ti] Título:Trackable Metallodrugs Combining Luminescent Re(I) and Bioactive Au(I) Fragments.
[So] Source:Inorg Chem;56(24):15159-15170, 2017 Dec 18.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hetero-bimetallic and -trimetallic complexes were synthesized by the combination of different metallic fragments, a luminescent Re(I) species, and a bioactive Au(I) derivative. A ditopic P,N-donor ligand (L) was used as linker between both metals, affording six new bipyridine (bipy) Re(I)/Au(I) hetero-metallic complexes of the type fac-[Re(bipy)(CO) (LAuCl)] (4-6) and [(fac-[Re(bipy)(CO) (L)]) Au] (7-9) after a thorough synthetic procedure. Their emission is associated with a triplet metal-to-ligand charge transfer (Re(dπ) → bipy(π*)) transition and red-shifted in polar solvents with lifetimes in the range of nanoseconds and quantum yield values up to 12.5%. Cytotoxicity values in A549 cells of hetero-trimetallic species are almost twice that for the hetero-bimetallic (ca. 37 vs 69 µM, respectively), being the L-Au fragment the source of the antiproliferative activity. Species 7 and 8 showed similar behavior by fluorescence microscopy, with a nonuniform cytoplasmatic distribution, a clear accumulation in single spots at the edge of the inner cell membrane as well as in areas within the nucleus. Preliminary studies suggest the DNA as one of the targets and passive diffusion as the entrance pathway.
[Mh] Termos MeSH primário: 2,2´-Dipiridil/química
Antineoplásicos/química
Complexos de Coordenação/química
Ouro/química
Substâncias Luminescentes/química
Rênio/química
[Mh] Termos MeSH secundário: 2,2'-Dipiridil/farmacocinética
2,2'-Dipiridil/farmacologia
Células A549
Antineoplásicos/farmacocinética
Antineoplásicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Complexos de Coordenação/farmacocinética
Complexos de Coordenação/farmacologia
Ouro/farmacocinética
Ouro/farmacologia
Seres Humanos
Ligantes
Luminescência
Substâncias Luminescentes/farmacocinética
Substâncias Luminescentes/farmacologia
Neoplasias/tratamento farmacológico
Imagem Óptica
Rênio/farmacocinética
Rênio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Ligands); 0 (Luminescent Agents); 551W113ZEP (2,2'-Dipyridyl); 7440-15-5 (Rhenium); 7440-57-5 (Gold)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b02470


  2 / 1850 MEDLINE  
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[PMID]:29272318
[Au] Autor:Mastren T; Radchenko V; Hopkins PD; Engle JW; Weidner JW; Copping R; Brugh M; Nortier FM; Birnbaum ER; John KD; Fassbender ME
[Ad] Endereço:Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
[Ti] Título:Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh.
[So] Source:PLoS One;12(12):e0190308, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ruthenium-103 is the parent isotope of 103mRh (t1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of 103Ru are generated through proton induced fission. The development of a two part chemical separation process to isolate 103Ru in high yield and purity from a proton irradiated thorium matrix on an analytical scale is described herein. The first part employed an anion exchange column to remove cationic actinide/lanthanide impurities along with the majority of the transition metal fission products. Secondly, an extraction chromatographic column utilizing diglycolamide functional groups was used to decontaminate 103Ru from the remaining impurities. This method resulted in a final radiochemical yield of 83 ± 5% of 103Ru with a purity of 99.9%. Additionally, measured nuclear reaction cross sections for the formation of 103Ru and 106Ru via the 232Th(p,f)103,106Ru reactions are reported within.
[Mh] Termos MeSH primário: Rênio/química
Radioisótopos de Rutênio/isolamento & purificação
Tório/isolamento & purificação
[Mh] Termos MeSH secundário: Prótons
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Protons); 0 (Ruthenium Radioisotopes); 0 (Ruthenium-103); 60YU5MIG9W (Thorium); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190308


  3 / 1850 MEDLINE  
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[PMID]:29235755
[Au] Autor:Shamelashvili KL; Shtemenko NI; Leus LV; Babiy SO; Shtemenko OV
[Ti] Título:Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system.
[So] Source:Ukr Biochem J;88(4):29-39, 2016 Jul-Aug.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Effects of the different modes of administration of dichlorotetra-µ-isobutyratodirhenium(ІІІ) ­ І ­ (in water solution, liposomes, nanoliposomes and together with cisplatin ­ in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocyte antioxidant enzymes were investigated on the model of tumor growth. A decrease in the concentration of TBA-active substances caused by dirhenium compounds was shown to be independent of the administration mode and the extent of the tumor growth inhibition. I was four-times more effective in inhibition of the LP burst than any known antioxidant. I induced the increasing activity of erythrocyte superoxide dismutase and decreasing activity of catalase. In vitro experiments with native superoxide dismutase, the interaction of І with following activation of the active center of the enzyme was confirmed and the superoxide dismutase activity of І was shown, that may contribute to the enhancement of the enzyme activity in vivo. The cluster rhenium compounds may be promising nontoxic potent antioxidants capable of deactivating superoxide radicals.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Antioxidantes/farmacologia
Carcinoma/tratamento farmacológico
Complexos de Coordenação/farmacologia
Platina/química
Rênio/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/síntese química
Antioxidantes/síntese química
Carcinoma/sangue
Carcinoma/metabolismo
Carcinoma/patologia
Catalase/sangue
Complexos de Coordenação/síntese química
Ativação Enzimática/efeitos dos fármacos
Eritrócitos/efeitos dos fármacos
Eritrócitos/enzimologia
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Lipossomos/administração & dosagem
Nanopartículas/administração & dosagem
Transplante de Neoplasias
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Wistar
Superóxido Dismutase/sangue
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Coordination Complexes); 0 (Liposomes); 0 (Thiobarbituric Acid Reactive Substances); 49DFR088MY (Platinum); 7440-15-5 (Rhenium); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.04.029


  4 / 1850 MEDLINE  
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[PMID]:28686334
[Au] Autor:Liu S; Dutta S; Zheng W; Gould NS; Cheng Z; Xu B; Saha B; Vlachos DG
[Ad] Endereço:Catalysis Center for Energy Innovation, Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, 19716, USA.
[Ti] Título:Catalytic Hydrodeoxygenation of High Carbon Furylmethanes to Renewable Jet-fuel Ranged Alkanes over a Rhenium-Modified Iridium Catalyst.
[So] Source:ChemSusChem;10(16):3225-3234, 2017 Aug 24.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Renewable jet-fuel-range alkanes are synthesized by hydrodeoxygenation of lignocellulose-derived high-carbon furylmethanes over ReO -modified Ir/SiO catalysts under mild reaction conditions. Ir-ReO /SiO with a Re/Ir molar ratio of 2:1 exhibits the best performance, achieving a combined alkanes yield of 82-99 % from C -C furylmethanes. The catalyst can be regenerated in three consecutive cycles with only about 12 % loss in the combined alkanes yield. Mechanistically, the furan moieties of furylmethanes undergo simultaneous ring saturation and ring opening to form a mixture of complex oxygenates consisting of saturated furan rings, mono-keto groups, and mono-hydroxy groups. Then, these oxygenates undergo a cascade of hydrogenolysis reactions to alkanes. The high activity of Ir-ReO /SiO arises from a synergy between Ir and ReO , whereby the acidic sites of partially reduced ReO activate the C-O bonds of the saturated furans and alcoholic groups while the Ir sites are responsible for hydrogenation with H .
[Mh] Termos MeSH primário: Irídio/química
Metano/química
Oxigênio/química
Rênio/química
[Mh] Termos MeSH secundário: Catálise
Furanos/química
Hidrogênio/química
Hidrogenação
Pressão
Dióxido de Silício/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furans); 44448S9773 (Iridium); 7440-15-5 (Rhenium); 7631-86-9 (Silicon Dioxide); 7YNJ3PO35Z (Hydrogen); OP0UW79H66 (Methane); S88TT14065 (Oxygen); UC0XV6A8N9 (furan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700863


  5 / 1850 MEDLINE  
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[PMID]:28566644
[Au] Autor:Mukai C
[Ad] Endereço:Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University.
[Ti] Título:Creation of Novel Cyclization Methods Using sp-Hybridized Carbon Units and Syntheses of Bioactive Compounds.
[So] Source:Chem Pharm Bull (Tokyo);65(6):511-523, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Some recent results on the development of new and reliable procedures for the construction of diverse ring systems based on the chemistry of sp-hybridized species, especially allene functionality, are described. This review includes: (i) synthesis of the multi-cyclic skeletons by combination of the π-component of allene with suitable other π-components such as alkyne, alkene, or additional allene under Rh-catalyzed conditions; (ii) synthesis of heterocycles as well as carbocycles by reaction of the sp-hybridized center of allene with some nucleophiles in an endo-mode manner; and (iii) total syntheses of natural products and related compounds from the sp-hybridized starting materials.
[Mh] Termos MeSH primário: Hidrocarbonetos/química
[Mh] Termos MeSH secundário: Produtos Biológicos/síntese química
Ciclização
Rênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Hydrocarbons); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00088


  6 / 1850 MEDLINE  
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[PMID]:28237731
[Au] Autor:Rodríguez Arce E; Machado I; Rodríguez B; Lapier M; Zúñiga MC; Maya JD; Olea Azar C; Otero L; Gambino D
[Ad] Endereço:Química Inorgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, 11800 Montevideo, Uruguay.
[Ti] Título:Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity against Trypanosoma cruzi.
[So] Source:J Inorg Biochem;170:125-133, 2017 May.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects about 10million people in Latin America, the current chemotherapy is still inadequate. The discovery of new drugs is urgently needed. Our group is focused on the development of prospective metal-based drugs mainly based on bioactive ligands and pharmacologically interesting metal ions. In this work three new rhenium(I) tricarbonyl compounds fac-[Re (CO) Br(HL)] where HL=5-nitrofuryl containing thiosemicarbazones were synthesized and fully characterized in solution and in the solid state. The in vitro evaluation of the compounds on T. cruzi trypomastigotes (Dm28c strain) showed that the Re(I) compounds are 8 to 15 times more active than the reference drug Nifurtimox and show a 4 to 17 fold increase in activity in respect to the free (HL) ligands. Obtained compounds also show good selectivity indexes (IC /IC ). H NMR and MS studies, performed with time, showed that the fac-[Re(CO) Br(HL)] species convert into the dimers [Re (CO) (L) ] in solution. Crystal structure of [Re (CO) (L2) ], the product of complexes' dimerization, was solved. Related to the mechanism of action, the studied compounds do not generate radical oxygen species in the parasite (as 5-nitrofuryl derived thiosemicarbazones do) probably due to the unfavorable nitro reduction potential of the generated dimeric species. On the contrary, the compounds produce a decrease of the oxygen consumption rate of the parasites, maybe inhibiting their mitochondrial respiration.
[Mh] Termos MeSH primário: Complexos de Coordenação
Rênio
Tiossemicarbazonas
Tripanossomicidas
Trypanosoma cruzi/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Complexos de Coordenação/síntese química
Complexos de Coordenação/química
Complexos de Coordenação/farmacologia
Rênio/química
Rênio/farmacologia
Tiossemicarbazonas/síntese química
Tiossemicarbazonas/química
Tiossemicarbazonas/farmacologia
Tripanossomicidas/síntese química
Tripanossomicidas/química
Tripanossomicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Thiosemicarbazones); 0 (Trypanocidal Agents); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


  7 / 1850 MEDLINE  
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[PMID]:28045339
[Au] Autor:Chen LC; Chang YJ; Chen SJ; Lee WC; Chang CH; Lee TW; Shien JH
[Ad] Endereço:a Department of Veterinary Medicine , National Chung Hsing University , Taichung , Taiwan.
[Ti] Título:Imaging, biodistribution and efficacy evaluation of Re-human serum albumin microspheres via intraarterial route in an orthotopic hepatoma model.
[So] Source:Int J Radiat Biol;93(5):477-486, 2017 May.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Liver cancer is the second most common cause of death worldwide. This study was to investigate the SPECT/CT, ultrasound, biodistribution and therapeutic evaluation of Re-human serum albumin microspheres ( Re-HSAM) in the GP7TB orthotopic hepatoma rat model. MATERIALS AND METHODS: HSAM was labeled with Re by using a home-made kit and microwave system. The Re-HSAM was administered via intraarterial route. The in vivo distribution of Re-HSAM was determined by biodistribution analysis and nanoSPECT/CT system. In efficacy, tumor volumes were tracked longitudinally by three-dimensional ultrasound. RESULTS: The biodistribution and nanoSPECT/CT imaging showed that Re-HSAM could accumulate in liver and tumor. The correlation coefficient of tumor volumes done by three-dimensional ultrasound and at autopsy was 0.997. In efficacy, tumor volume in the normal saline-treated group was 1803.2 mm at 54 days after tumor inoculation. Tumor volumes in the 103.6 MBq and 240.5 MBq of Re-HSAM treated groups were 381 and 267.4 mm (p = 0.001 and 0.004), respectively. CONCLUSIONS: These results show that three-dimensional ultrasound with a high spatial resolution and contrast in soft tissue can become imaging modality in assessing tumor burden and tumor progression in an orthotopic rat model. The longitudinally therapeutic evaluation of Re-HSAM demonstrated dose-dependent tumor growth inhibition with increased dose in the GP7TB orthotopic hepatoma rat model.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/metabolismo
Carcinoma Hepatocelular/radioterapia
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/radioterapia
Radioisótopos/administração & dosagem
Rênio/administração & dosagem
Rênio/farmacocinética
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos da radiação
Cápsulas/síntese química
Cápsulas/farmacocinética
Carcinoma Hepatocelular/diagnóstico por imagem
Linhagem Celular Tumoral
Injeções Intra-Arteriais
Neoplasias Hepáticas/diagnóstico por imagem
Masculino
Especificidade de Órgãos
Radioisótopos/farmacocinética
Compostos Radiofarmacêuticos/administração & dosagem
Compostos Radiofarmacêuticos/farmacocinética
Ratos Endogâmicos F344
Albumina Sérica/química
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
Nanomedicina Teranóstica
Distribuição Tecidual
Resultado do Tratamento
Carga Tumoral/efeitos da radiação
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsules); 0 (Radioisotopes); 0 (Radiopharmaceuticals); 0 (Serum Albumin); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1080/09553002.2017.1276308


  8 / 1850 MEDLINE  
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[PMID]:28007432
[Au] Autor:Esquinas PL; Rodríguez-Rodríguez C; Carlos De La Vega J; Bokharaei M; Saatchi K; Shirmohammad M; Häfeli UO; Sossi V; Celler A
[Ad] Endereço:Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. Electronic address: esquinas@phas.ubc.ca.
[Ti] Título:Re image performance assessment using small animal multi-pinhole SPECT/PET/CT system.
[So] Source:Phys Med;33:26-37, 2017 Jan.
[Is] ISSN:1724-191X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The goal of this study was to investigate the performance of a pre-clinical SPECT/PET/CT system for Re imaging. METHODS: Phantom experiments were performed aiming to assess the characteristics of two multi-pinhole collimators: ultra-high resolution collimator (UHRC) and high-energy ultra high resolution collimator (HE-URHC) for imaging Re. The spatial resolution, image contrast and contrast-to-noise ratio (CNR) were investigated using micro-Jaszczak phantoms. Additionally, the quantification accuracy of Re images was evaluated using two custom-designed phantoms. The Re images were compared to those obtained with Tc (gold standard); the acquired energy spectra were analyzed and Monte-Carlo simulations of the UHRC were performed. To verify our findings, a C57BL/6-mouse was injected with Re-microspheres and scanned with both collimators. RESULTS: The spatial resolution achieved in Re images was comparable to that of Tc. Acquisitions using HE-UHRC yielded Re images with higher contrast and CNR than UHRC. Studies of quantitative accuracy of Re images resulted in <10% errors for both collimators when the activity was calculated within a small VOI around the object of interest. Similar quantification accuracy was achieved for Tc. However, Re images showed much higher levels of noise in the background. Monte-Carlo simulations showed that Re imaging with UHRC is severely affected by down-scattered photons from high-energy emissions. The mouse images showed similar biodistribution of Re-microspheres for both collimators. CONCLUSIONS: VECTor/CT provided Re images quantitatively accurate and with quality comparable to Tc. However, due to large penetration of UHRC by high-energy photons, the use of the HE-UHRC for imaging Re in VECTor/CT is recommended.
[Mh] Termos MeSH primário: Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Rênio
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Animais
Processamento de Imagem Assistida por Computador
Camundongos
Método de Monte Carlo
Imagens de Fantasmas
Radioisótopos
Razão Sinal-Ruído
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radioisotopes); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE


  9 / 1850 MEDLINE  
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[PMID]:27909710
[Au] Autor:Wedding JL; Harris HH; Bader CA; Plush SE; Mak R; Massi M; Brooks DA; Lai B; Vogt S; Werrett MV; Simpson PV; Skelton BW; Stagni S
[Ad] Endereço:Department of Chemistry, The University of Adelaide, SA 5005, Australia. hugh.harris@adelaide.edu.au.
[Ti] Título:Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging.
[So] Source:Metallomics;9(4):382-390, 2017 Apr 19.
[Is] ISSN:1756-591X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO) (phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc.
[Mh] Termos MeSH primário: Complexos de Coordenação/análise
Substâncias Luminescentes/análise
Microscopia de Fluorescência/métodos
Imagem Óptica/métodos
Rênio/análise
Tetrazóis/análise
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Fenantrolinas/análise
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Luminescent Agents); 0 (Phenanthrolines); 0 (Tetrazoles); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1039/c6mt00243a


  10 / 1850 MEDLINE  
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[PMID]:27816527
[Au] Autor:Krasilnikova AA; Solovieva AO; Ivanov AA; Trifonova KE; Pozmogova TN; Tsygankova AR; Smolentsev AI; Kretov EI; Sergeevichev DS; Shestopalov MA; Mironov YV; Shestopalov AM; Poveshchenko AF; Shestopalova LV
[Ad] Endereço:Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russian Federation; Scientific Institute of Clinical and Experimental LymÑ€hology, Novosibirsk, Russian Federation; Novosibirsk State University, Novosibirsk, Russian Federation.
[Ti] Título:Comprehensive study of hexarhenium cluster complex Na [{Re Te }(CN) ] - In terms of a new promising luminescent and X-ray contrast agent.
[So] Source:Nanomedicine;13(2):755-763, 2017 Feb.
[Is] ISSN:1549-9642
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Octahedral rhenium cluster complexes may have considerable potential as therapeutic and diagnostic drugs due to their luminescent and X-ray contrast properties, as well as their ability to generate singlet oxygen upon photoirradiation. However, their potential biological effects and toxicity in vitro and in vivo are rather far from being understood. Thus, the aim of our research was to study cytotoxicity, intracellular localization and cellular uptake/elimination kinetics in vitro, biodistribution and acute intravenous toxicity in vivo of a complex Na [{Re Te }(CN) ] as the promising compound for biomedical application. The results have demonstrated that the complex penetrates through cell membranes with the maximum accumulation in cells in 24h of incubation and have low toxic effects in vitro and in vivo. The median lethal dose (LD ) of intravenously administrated Na [{Re Te }(CN) ] is equal to 1082±83mg/kg. These findings will be useful for future development of cluster-based agents for different biomedical applications.
[Mh] Termos MeSH primário: Meios de Contraste
Rênio
[Mh] Termos MeSH secundário: Seres Humanos
Luminescência
Distribuição Tecidual
Células Tumorais Cultivadas
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 7440-15-5 (Rhenium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE



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