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[PMID]: 29381740 [Au] Autor: Khokhar JS; Sareen S; Tyagi BS; Singh G; Wilson L; King IP; Young SD; Broadley MR [Ad] Endereço: School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom. [Ti] Título: Variation in grain Zn concentration, and the grain ionome, in field-grown Indian wheat. [So] Source: PLoS One;13(1):e0192026, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Wheat is an important dietary source of zinc (Zn) and other mineral elements in many countries. Dietary Zn deficiency is widespread, especially in developing countries, and breeding (genetic biofortification) through the HarvestPlus programme has recently started to deliver new wheat varieties to help alleviate this problem in South Asia. To better understand the potential of wheat to alleviate dietary Zn deficiency, this study aimed to characterise the baseline effects of genotype (G), site (E), and genotype by site interactions (GxE) on grain Zn concentration under a wide range of soil conditions in India. Field experiments were conducted on a diverse panel of 36 Indian-adapted wheat genotypes, grown on a range of soil types (pH range 4.5-9.5), in 2013-14 (five sites) and 2014-15 (six sites). Grain samples were analysed using inductively coupled plasma-mass spectrometry (ICP-MS). The mean grain Zn concentration of the genotypes ranged from 24.9-34.8 mg kg-1, averaged across site and year. Genotype and site effects were associated with 10% and 6% of the overall variation in grain Zn concentration, respectively. Whilst G x E interaction effects were evident across the panel, some genotypes had consistent rankings between sites and years. Grain Zn concentration correlated positively with grain concentrations of iron (Fe), sulphur (S), and eight other elements, but did not correlate negatively with grain yield, i.e. no yield dilution was observed. Despite a relatively small contribution of genotype to the overall variation in grain Zn concentration, due to experiments being conducted across many contrasting sites and two years, our data are consistent with reports that biofortifying wheat through breeding is likely to be effective at scale given that some genotypes performed consistently across diverse soil types. Notably, all soils in this study were probably Zn deficient and interactions between wheat genotypes and soil Zn availability/management (e.g. the use of Zn-containing fertilisers) need to be better-understood to improve Zn supply in food systems. [Mh] Termos MeSH primário: Triticum/metabolismo Zinco/metabolismo [Mh] Termos MeSH secundário: Índia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180131 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0192026

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[PMID]: 29373588 [Au] Autor: Muszynski S; Tomaszewska E; Kwiecien M; Dobrowolski P; Tomczyk-Warunek A [Ad] Endereço: Department of Physics, Faculty of Production Engineering, University of Life Sciences in Lublin, Lublin, Poland. [Ti] Título: Subsequent somatic axis and bone tissue metabolism responses to a low-zinc diet with or without phytase inclusion in broiler chickens. [So] Source: PLoS One;13(1):e0191964, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Zinc is required for normal bone development and cartilage formation. The purpose of this study was to assess the effect of with adding organic Zn (alone or phytase inclusion) at the reduced dose to growing male Ross 308 chickens on somatic axis and bone tissue metabolism. 200 one-day old broilers were divided into the negative control group fed diet without Zn or phytase inclusion, positive control group receiving Zn in the 100% of daily recommended dose from ZnO, and two experimental groups fed diet introduced Zn in 25% of daily recommendation as a glycine chelate (Zn-Gly) with or without phytase inclusion (500 FTU·kg-1). Supplemental organic Zn increased bone Zn and Mg content, serum IGF-1, growth hormone and leptin concentration. Additional phytase inclusion increased body weight gain, blood plasma Ca, Fe, Zn and osteocalcin concentration and tibia ash percentage when compared to the Zn-deprived control. Bone geometry, yield and ultimate strengths were enhanced in both organic Zn supplemented groups, and the overall mechanical strength parameters of bone were better in these groups than in the positive control group supplemented with standard dose of inorganic Zn. Also marked improvements in the thickness of articular and the growth plate cartilages as well as real bone volume and thickness of metaphyseal trabeculae were achieved in all broilers fed Zn-supplemented diet irrespective of phytase inclusion, however, the highest cancellous bone mass and the best trabecular structure were noted after ZnO supplementation. In concludion, although dietary organic Zn given to growing broilers in 25% of daily recommended dose improved general bone properties and mechanical strength, the obtained results do not allow to unambiguously state that organic Zn supplementation at this level, even after phytase inclusion, is sufficient for proper bone development. [Mh] Termos MeSH primário: 6-Fitase/metabolismo Osso e Ossos/metabolismo Zinco/administração & dosagem [Mh] Termos MeSH secundário: Animais Galinhas Hormônio do Crescimento/metabolismo Fator de Crescimento Insulin-Like I/metabolismo Leptina/metabolismo Magnésio/metabolismo Masculino Zinco/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Leptin); 67763-96-6 (Insulin-Like Growth Factor I); 9002-72-6 (Growth Hormone); EC 3.1.3.26 (6-Phytase); I38ZP9992A (Magnesium); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180127 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191964

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[PMID]: 29342185 [Au] Autor: Deshpande P; Dapkekar A; Oak M; Paknikar K; Rajwade J [Ad] Endereço: Nanobioscience group, Agharkar Research Institute, Pune, India. [Ti] Título: Nanocarrier-mediated foliar zinc fertilization influences expression of metal homeostasis related genes in flag leaves and enhances gluten content in durum wheat. [So] Source: PLoS One;13(1):e0191035, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Wheat is the staple food for most of the world's population; however, it is a poor source of zinc. Foliar fertilization of zinc via zinc loaded chitosan nanocarriers (Zn-CNP) post-anthesis has proved to be a promising approach for grain zinc enhancement in durum wheat as evidenced in our earlier study. However, the molecular mechanism of uptake of zinc via Zn-CNP remains unclear. METHODS/PRINCIPLE FINDINGS: Foliar application of Zn-CNP was performed at post anthesis stages in two durum wheat cultivars (MACS 3125 and UC1114, containing the Gpc-B1 gene), and expression levels of several metal-related genes were analyzed during early senescence. Zn-CNP application indeed caused changes in gene expression as revealed by qPCR data on representative genes involved in metal homeostasis, phloem transporters, and leaf senescence. Furthermore, zinc-regulated transporters and iron (Fe)-regulated transporter-like protein (ZIP) family [ZIP1, ZIP7, ZIP15], CA (carbonic anhydrase), and DMAS (2'-deoxymugineic acid synthase) in flag leaves exhibited significant correlation with zinc content in the seeds. The analysis of grain endosperm proteins showed enhancement of gamma gliadins while other gluten subunits decreased. Gene expression within ZIP family members varied with the type of cultivar mostly attributed to the Gpc-B1, concentration of external zinc ions as well as the type of tissue analyzed. Correlation analysis revealed the involvement of the selected genes in zinc enhancement. CONCLUSION: At the molecular level, uptake of zinc via Zn-CNP nanocarrier was comparable to the uptake of zinc via common zinc fertilizers i.e. ZnSO4. [Mh] Termos MeSH primário: Genes de Plantas Homeostase Metais/metabolismo Nanopartículas Triticum/genética Zinco/administração & dosagem [Mh] Termos MeSH secundário: Glutens/metabolismo Folhas de Planta/genética Folhas de Planta/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Metals); 8002-80-0 (Glutens); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180118 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191035

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[PMID]: 28865349 [Au] Autor: Li X; Zhang D; Sheng F; Qing H [Ad] Endereço: Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Conservancy, Chengdu 610041, China. [Ti] Título: Adsorption characteristics of Copper (â…¡), Zinc (â…¡) and Mercury (â…¡) by four kinds of immobilized fungi residues. [So] Source: Ecotoxicol Environ Saf;147:357-366, 2018 Jan. [Is] ISSN: 1090-2414 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: This study investigated the adsorption characteristics of Copper (â…¡), Zinc (â…¡) and Mercury (â…¡) by immobilized Flammulina velutipes, Auricularia polytricha, Pleurotus eryngii and Pleurotus ostreatus residues. Lagergren model, elovich and intraparticle diffusion model were used to present the adsorption kinetics, and it was proved that Langmuir isotherm model and pseudo-second order kinetics are the best suitable model with high correlation coefficient to characterize the adsorption process of Copper (â…¡), Zinc (â…¡) and Mercury (â…¡). The results showed that adsorption process finished in 120min at pH 6.0. The adsorption rate of Cu , Zn and Hg were reached to 53.8-84.1% of total in the initial 60min, and finished in 120min. Ion exchange and complexation of F. velutipes were the main mechanisms for adsorption of metal ions by characterizations of Scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). In addition the functional group of cell walls such as hydroxyl, amide, carbonyl, phosphoric played a critical role in ions adsorption of edible mushroom residues. Cu , Zn and Hg in wastewater could be efficiently removed by F. velutipes residue with removal ratio of 73.11%, 66.67% and 69.35%, respectively. [Mh] Termos MeSH primário: Agaricales/química Cobre/análise Mercúrio/análise Modelos Teóricos Poluentes Químicos da Água/análise Zinco/análise [Mh] Termos MeSH secundário: Adsorção Cobre/química Difusão Concentração de Íons de Hidrogênio Íons Cinética Mercúrio/química Resíduos Sólidos/análise Termodinâmica Águas Residuais/química Poluentes Químicos da Água/química Purificação da Água/métodos Zinco/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ions); 0 (Solid Waste); 0 (Waste Water); 0 (Water Pollutants, Chemical); 789U1901C5 (Copper); FXS1BY2PGL (Mercury); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170903 [St] Status: MEDLINE

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[PMID]: 29267507 [Au] Autor: Liu N; Ding D; Wang L; Zhao H; Zhu L; Geng X [Ad] Endereço: Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. [Ti] Título: Two novel Mg(II)-based and Zn(II)-based complexes: inhibiting growth of human liver cancer cells. [So] Source: Braz J Med Biol Res;51(2):e6929, 2017 Dec 18. [Is] ISSN: 1414-431X [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Two new Mg(II)-based and Zn(II)-based coordination polymers, {[Mg3(BTB)(DMA)4](DMA)2}n (1, H3BTB=1,3,5-benzenetrisbenzoic acid, DMA=N,N-dimethylacetamide) and {(H2NMe2)2[Zn3(BTB)2(OH)(Im)](DMF)9(MeOH)7}n (2, Im=imidazole, DMF=N,N-dimethylformamide), have been successfully synthesized and structurally characterized under solvothermal conditions. 1 contains a linear [Mg3(COO)6] cluster that connected by the fully deprotonated BTB3- ligands to give a kgd-type 2D bilayer structure; 2 represents a microporous 3D pillar-layered system based on the binuclear Zn units and pillared Im ligands, which shows a (3,5)-connected hms topological net. In addition, in vitro anticancer activities of compounds 1 and 2 on 4 human liver cancer cells (HB611, HHCC, BEL-7405 and SMMC-7721) were determined. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Benzimidazóis/farmacologia Neoplasias Hepáticas/tratamento farmacológico Estruturas Metalorgânicas/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/síntese química Benzimidazóis/síntese química Linhagem Celular Tumoral Seres Humanos Ligantes Neoplasias Hepáticas/patologia Magnésio/química Estruturas Metalorgânicas/síntese química Estrutura Molecular Zinco/química [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Benzimidazoles); 0 (Ligands); 0 (Metal-Organic Frameworks); I38ZP9992A (Magnesium); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171222 [St] Status: MEDLINE

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[PMID]: 29194015 [Au] Autor: Tripathi P; A JL; Kapoor M [Ad] Endereço: a Department of Protein Chemistry and Technology , CSIR-Central Food Technological Research Institute , Mysuru , Karnataka , India. [Ti] Título: Phytase from Citrobacter koseri PM-7: Enhanced production using statistical method and application in ameliorating mineral bioaccessibility and protein digestibility of high-phytate food. [So] Source: Prep Biochem Biotechnol;48(1):84-91, 2018 Jan 02. [Is] ISSN: 1532-2297 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The present study was aimed at enhancing phytase (Phy-Ck) production from Citrobacter koseri PM-7 using response surface methodology (RSM) and improving the bioaccessibility of minerals (Fe and Zn) and protein digestibility in high-phytate food using Phy-Ck. A five-variable and three-level central composite design of RSM using wheat bran (6.681%, w/v), inoculum level (2.5%, v/v), and triton X-100 (0.2%, v/v) resulted in up to 5.57-fold (1.047 U/ml) improvement in Phy-Ck yield from C. koseri PM-7 when compared with fermentation media I and II. The model was successfully validated in the design space by taking a random set of variable combinations. Treatment of high-phytate food with partially purified Phy-Ck showed improvement in mineral bioaccessibility maximally for defatted sesame flour (DSF) (Fe 45.5%; Zn 50.7%) followed by wheat flour (WF) (Fe 13.5%; Zn 14.4%), green gram flour (GGF) (Fe 0.7%; Zn 3.8%) and defatted groundnut flour (DGF) (Zn 5.6%). The in vitro protein digestibility (IVPD) of WF increased from 48.83 to 65.04%, GGF from 45.04 to 57.12%, and DSF from 47.34 to 55.7% after Phy-Ck treatment. [Mh] Termos MeSH primário: 6-Fitase/metabolismo Citrobacter koseri/enzimologia [Mh] Termos MeSH secundário: Ração Animal/análise Fibras na Dieta/análise Fermentação Farinha/análise Ferro/metabolismo Ácido Fítico/análise Ácido Fítico/metabolismo Proteólise Triticum/química Zinco/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dietary Fiber); 7IGF0S7R8I (Phytic Acid); E1UOL152H7 (Iron); EC 3.1.3.26 (6-Phytase); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171202 [St] Status: MEDLINE [do] DOI: 10.1080/10826068.2017.1405024

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[PMID]: 29181620 [Au] Autor: Real MIH; Azam HM; Majed N [Ad] Endereço: Department of Civil Engineering, University of Asia Pacific, Dhaka, Bangladesh. [Ti] Título: Consumption of heavy metal contaminated foods and associated risks in Bangladesh. [So] Source: Environ Monit Assess;189(12):651, 2017 Nov 27. [Is] ISSN: 1573-2959 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: This study investigated the magnitude of heavy metal contamination and determined the carcinogenic as well as non-carcinogenic risks associated with selected food consumption in Bangladesh. Commonly consumed varieties of rice, vegetables, and fish samples were analyzed to measure the concentrations of heavy metals such as cadmium, chromium, lead, arsenic, manganese, nickel, and zinc. These staple food items showed the greatest probabilities of heavy metal contamination in different phases of their production and marketing. Wide variations of metal concentrations were observed. Specifically, estimated daily intakes of arsenic and cadmium exceeded allowable daily intakes in all three food items. Toxicity scores of the metals were evaluated, and a comprehensive risk assessment was conducted to quantify the risks associated with the daily food consumption. Except for cadmium and lead in vegetables, all the contaminants present in each food item posed significant levels of carcinogenic risks up to 2.99 × 10 compared to the EPA recommended carcinogenic risk level of 1.0 × 10 . Cadmium and arsenic intake due to rice consumption also posed unsafe levels of non-carcinogenic risks of 4.587 and 6.648, respectively, compared to the EPA recommended non-carcinogenic risk level of 1.0. Finally, a revised set of permissible limits was proposed for the heavy metals detected in the food items. Those permissible limits would ensure the risks associated with food consumption below the allowable carcinogenic and non-carcinogenic risk levels. Thus, this comprehensive approach would provide guidelines to formulate adequate control measures and regulatory limits of toxic metals in foods produced and marketed in Bangladesh. [Mh] Termos MeSH primário: Exposição Dietética/estatística & dados numéricos Poluentes Ambientais/análise Contaminação de Alimentos/análise Metais Pesados/análise [Mh] Termos MeSH secundário: Animais Arsênico/análise Bangladesh Cádmio/análise Cromo Monitoramento Ambiental Peixes Contaminação de Alimentos/estatística & dados numéricos Seres Humanos Níquel Medição de Risco Verduras/química Zinco [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Environmental Pollutants); 0 (Metals, Heavy); 00BH33GNGH (Cadmium); 0R0008Q3JB (Chromium); 7OV03QG267 (Nickel); J41CSQ7QDS (Zinc); N712M78A8G (Arsenic) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171129 [St] Status: MEDLINE [do] DOI: 10.1007/s10661-017-6362-z

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[PMID]: 29374929 [Au] Autor: Wang XX; Zhang MJ; Li XB [Ad] Endereço: The First Central Clinical College, Tianjin Medical University, Tianjin 300070, China. [Ti] Título: [Advances in the research of zinc deficiency and zinc supplementation treatment in patients with severe burns]. [So] Source: Zhonghua Shao Shang Za Zhi;34(1):57-59, 2018 Jan 20. [Is] ISSN: 1009-2587 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: Zinc is one of the essential trace elements in human body, which plays an important role in regulating acute inflammatory response, glucose metabolism, anti-oxidation, immune and gastrointestinal function of patients with severe burns. Patients with severe burns may suffer from zinc deficiency because of insufficient amount of zinc intake from the diet and a large amount of zinc lose through wounds and urine. Zinc deficiency may affect their wound healing process and prognosis. This article reviews the characteristics of zinc metabolism in patients with severe burns through dynamic monitoring the plasma and urinary concentration of zinc. An adequate dosage of zinc supplemented to patients with severe burns by an appropriate method can increase the level of zinc in plasma and skin tissue and improve wound healing, as well as reduce the infection rates and mortality. At the same time, it is important to observe the symptoms and signs of nausea, dizziness, leukopenia and arrhythmia in patients with severe burns after supplementing excessive zinc. [Mh] Termos MeSH primário: Queimaduras/terapia Cicatrização Zinco/deficiência Zinco/uso terapêutico [Mh] Termos MeSH secundário: Queimaduras/complicações Seres Humanos Pele Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180129 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.1009-2587.2018.01.012

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[PMID]: 29478648 [Au] Autor: Tella AC; Owalude SO; Olatunji SJ; Adimula VO; Elaigwu SE; Alimi LO; Ajibade PA; Oluwafemi OS [Ad] Endereço: Department of Chemistry, University of Ilorin, P.M.B.1515 Ilorin, Nigeria. Electronic address: ac_tella@yahoo.co.uk. [Ti] Título: Synthesis of zinc-carboxylate metal-organic frameworks for the removal of emerging drug contaminant (amodiaquine) from aqueous solution. [So] Source: J Environ Sci (China);64:264-275, 2018 Feb. [Is] ISSN: 1001-0742 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: We herein report the removal of amodiaquine, an emerging drug contaminant from aqueous solution using [Zn (fum) (bpy)] and [Zn O(bdc) ] (fum=fumaric acid; bpy=4,4-bipyridine; bdc=benzene-1,4-dicarboxylate) metal-organic frameworks (MOFs) as adsorbents. The adsorbents were characterized by elemental analysis, Fourier transform infrared (FT-IR) spectroscopy, and powder X-ray diffraction (PXRD). Adsorption process for both adsorbents were found to follow the pseudo-first-order kinetics, and the adsorption equilibrium data fitted best into the Freundlich isotherm with the R values of 0.973 and 0.993 obtained for [Zn (fum) (bpy)] and [Zn O(bdc) ] respectively. The maximum adsorption capacities foramodiaquine in this study were found to be 0.478 and 47.62mg/g on the [Zn (fum) (bpy)] and [Zn O(bdc) ] MOFs respectively, and were obtained at pH of 4.3 for both adsorbents. FT-IR spectroscopy analysis of the MOFs after the adsorption process showed the presence of the drug. The results of the study showed that the prepared MOFs could be used for the removal of amodiaquine from wastewater. [Mh] Termos MeSH primário: Amodiaquina/análise Estruturas Metalorgânicas/química Eliminação de Resíduos Líquidos/métodos Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: Adsorção Amodiaquina/química Ácidos Carboxílicos/química Águas Residuais/química Poluentes Químicos da Água/química Difração de Raios X Zinco/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Carboxylic Acids); 0 (Metal-Organic Frameworks); 0 (Waste Water); 0 (Water Pollutants, Chemical); 220236ED28 (Amodiaquine); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180227 [St] Status: MEDLINE

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[PMID]: 29386451 [Au] Autor: Kodama H [Ad] Endereço: Department of Health and Dietetics, Faculty of Health and Medical Sciences, Teikyo Heisei University. [Ti] Título: [Recent Trends of Trace Element Studies in Clinical Medicine in Japan]. [So] Source: Nihon Eiseigaku Zasshi;73(1):75-82, 2018. [Is] ISSN: 1882-6482 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Deficiencies of selenium and iodine are observed in patients who receive special formulas of milk and enteral formula with low selenium and iodine concentrations, respectively. In contrast, neonatal transient hypothyroidism due to excess intake of iodine in pregnant women has also reported in Japan. It is expected that collaborative studies by researchers and clinicians will contribute to clarify the detail mechanism, diagnosis and treatment of these abnormalities. [Mh] Termos MeSH primário: Medicina Clínica/tendências Oligoelementos [Mh] Termos MeSH secundário: Cobre/deficiência Feminino Degeneração Hepatolenticular Seres Humanos Hipotireoidismo Recém-Nascido Japão Masculino Síndrome dos Cabelos Torcidos Gravidez Selênio/deficiência Oligoelementos/deficiência Zinco/deficiência [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Trace Elements); 789U1901C5 (Copper); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180228 [Lr] Data última revisão: 180228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180202 [St] Status: MEDLINE [do] DOI: 10.1265/jjh.73.75

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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde