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[PMID]:27775192
[Au] Autor:Dasari S; Singh S; Sivakumar S; Patra AK
[Ad] Endereço:Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India.
[Ti] Título:Dual-Sensitized Luminescent Europium(ΙΙΙ) and Terbium(ΙΙΙ) Complexes as Bioimaging and Light-Responsive Therapeutic Agents.
[So] Source:Chemistry;22(48):17387-17396, 2016 Nov 21.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dual-photosensitized stable Eu and Tb complexes, namely [Eu(dpq)(tfnb) ] (1) and [Tb(dpq)(tfnb) ] (2), in which dpq=dipyrido[3,2-d:2',3'-f]quinoxaline and Htfnb=4,4,4-trifluoro-1-(2-napthyl)-1,3-butanedione, were designed as bioimaging and light-responsive therapeutic agents. Their X-ray structures, photophysical properties, biological interactions, photoinduced DNA damage, photocytotoxicity, and cellular uptake properties were studied. Discrete mononuclear complexes adopt an eight-coordinated {LnN O } distorted square antiprism geometry with bidentate N,N-donor dpq and O,O-donor tfnb ligands. The designed probes have the advantage of dual-sensitizing antennae (dpq, Htfnb) to modulate their desirable optical properties for cellular imaging and light-responsive intracellular damage. The remarkable photostability, absence of inner-sphere water (q<1), and longer excited-state lifetimes of the complexes make them suitable as cellular-imaging probes. The dpq T state is well located energetically to allow efficient energy transfer (ET) to the emissive D and D states of Eu and Tb . This leads to higher quantum yields (φ=0.15-0.20) in aqueous media and makes these compounds suitable cellular-imaging probes. The complexes display significant binding ability toward DNA and bovine serum albumin (K≈10 m ). They effectively cleave supercoiled DNA to its nicked circular form at λ=365 nm through photoredox pathways. The cellular internalization studies showed cytosolic and nuclear localization. The remarkable photocytotoxicity of these probes offers a strategy towards developing photoresponsive Ln probes as cellular-imaging and phototherapeutic agents.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
DNA/química
Európio/química
Substâncias Luminescentes/química
Compostos Organometálicos/química
Compostos Organometálicos/uso terapêutico
Fármacos Fotossensibilizantes/química
Soroalbumina Bovina/química
Térbio/química
[Mh] Termos MeSH secundário: Ligantes
Luminescência
Quinoxalinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Luminescent Agents); 0 (Organometallic Compounds); 0 (Photosensitizing Agents); 0 (Quinoxalines); 06SSF7P179 (Terbium); 27432CM55Q (Serum Albumin, Bovine); 444W947O8O (Europium); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201603453


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[PMID]:27775336
[Au] Autor:Zercher B; Hopkins TA
[Ad] Endereço:Department of Chemistry, Butler University , 4600 Sunset Avenue, Indianapolis, Indiana 46208, United States.
[Ti] Título:Induction of Circularly Polarized Luminescence from Europium by Amino Acid Based Ionic Liquids.
[So] Source:Inorg Chem;55(21):10899-10906, 2016 Nov 07.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Materials that emit circularly polarized light have application in several important industries. Because they show large optical activity and emit sharp visible light transitions, europium complexes are often exploited in applications that require circularly polarized luminescence (CPL). Chiral and coordinating ionic liquids based on prolinate, valinate, and aspartate anions are used to induce CPL from a simple achiral europium triflate salt. The sign of the induced CPL is dependent on the handedness (l vs d) of the amino acid anion. Comparison of the CPL spectra in ionic liquid with proline and valine vs aspartate shows that the number of carboxylate groups in the amino acid anion influences the europium coordination environment. DFT calculations predict a chiral eight-coordinate Eu(Pro) structure in the prolinate ionic liquid and a chiral seven- or eight-coordinate Eu(Asp) structure in the aspartate ionic liquid.
[Mh] Termos MeSH primário: Aminoácidos/química
Európio/química
Líquidos Iônicos/química
Substâncias Luminescentes/química
Mesilatos/química
[Mh] Termos MeSH secundário: Ácido Aspártico/química
Complexos de Coordenação/química
Luminescência
Medições Luminescentes
Modelos Moleculares
Prolina/química
Valina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Coordination Complexes); 0 (Ionic Liquids); 0 (Luminescent Agents); 0 (Mesylates); 30KYC7MIAI (Aspartic Acid); 444W947O8O (Europium); 9DLQ4CIU6V (Proline); HG18B9YRS7 (Valine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29220150
[Au] Autor:Jia J; Zhang Y; Zheng M; Shan C; Yan H; Wu W; Gao X; Cheng B; Liu W; Tang Y
[Ad] Endereço:State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, and ‡Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, La
[Ti] Título:Functionalized Eu(III)-Based Nanoscale Metal-Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy.
[So] Source:Inorg Chem;57(1):300-310, 2018 Jan 02.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective and safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a ß-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene blue, MB) in the pores and a cyclic peptide targeting motif on the surface of the NMOF, which could achieve highly efficient near-infrared (NIR)-triggered and -targeted photodynamic therapy (PDT). On the basis of the luminescence resonance energy transfer process between the NMOF donor and the photosensitizer MB acceptor, the probe can achieve a high tissue-penetrable TPA-PDT effect. Thus, the NMOFs in this study play the role of not only the nanocontainer for the photosensitizer but also the energy-transfer donor. Studies in vitro show enhanced cellular uptake and satisfactory PDT effectiveness toward cancer cells compared to the free photosensitizer MB. It is highly expected that this study contributes to the development of smart luminescent diagnostic and therapeutic probes.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Európio/farmacologia
Sondas Moleculares/farmacologia
Compostos Organometálicos/farmacologia
Fotoquimioterapia
Fótons
Fármacos Fotossensibilizantes/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Morte Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Európio/química
Seres Humanos
Raios Infravermelhos
Sondas Moleculares/síntese química
Sondas Moleculares/química
Nanopartículas/química
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Tamanho da Partícula
Fármacos Fotossensibilizantes/síntese química
Fármacos Fotossensibilizantes/química
Propriedades de Superfície
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Molecular Probes); 0 (Organometallic Compounds); 0 (Photosensitizing Agents); 444W947O8O (Europium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b02475


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[PMID]:29017510
[Au] Autor:de Schellenberger AA; Hauptmann R; Millward JM; Schellenberger E; Kobayashi Y; Taupitz M; Infante-Duarte C; Schnorr J; Wagner S
[Ad] Endereço:Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. angela.ariza@charite.de.
[Ti] Título:Synthesis of europium-doped VSOP, customized enhancer solution and improved microscopy fluorescence methodology for unambiguous histological detection.
[So] Source:J Nanobiotechnology;15(1):71, 2017 Oct 10.
[Is] ISSN:1477-3155
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intrinsic iron in biological tissues frequently precludes unambiguous the identification of iron oxide nanoparticles when iron-based detection methods are used. Here we report the full methodology for synthesizing very small iron oxide nanoparticles (VSOP) doped with europium (Eu) in their iron oxide core (Eu-VSOP) and their unambiguous qualitative and quantitative detection by fluorescence. METHODS AND RESULTS: The resulting Eu-VSOP contained 0.7 to 2.7% Eu relative to iron, which was sufficient for fluorescent detection while not altering other important particle parameters such as size, surface charge, or relaxivity. A customized enhancer solution with high buffer capacity and nearly neutral pH was developed to provide an antenna system that allowed fluorescent detection of Eu-VSOP in cells and histologic tissue slices as well as in solutions even under acidic conditions as frequently obtained from dissolved organic material. This enhancer solution allowed detection of Eu-VSOP using a standard fluorescence spectrophotometer and a fluorescence microscope equipped with a custom filter set with an excitation wavelength (λ ) of 338 nm and an emission wavelength (λ ) of 616 nm. CONCLUSION: The fluorescent detection of Eu-doped very small iron oxide nanoparticles (Eu-VSOP) provides a straightforward tool to unambiguously characterize VSOP biodistribution and toxicology at tissue, and cellular levels, providing a sensitive analytical tool to detect Eu-doped IONP in dissolved organ tissue and biological fluids with fluorescence instruments.
[Mh] Termos MeSH primário: Európio/análise
Compostos Férricos/análise
Nanopartículas/análise
[Mh] Termos MeSH secundário: Animais
Európio/farmacocinética
Compostos Férricos/síntese química
Compostos Férricos/farmacocinética
Camundongos
Camundongos Endogâmicos C57BL
Microscopia de Fluorescência/métodos
Nanopartículas/ultraestrutura
Nanotecnologia/métodos
Células RAW 264.7
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 1K09F3G675 (ferric oxide); 444W947O8O (Europium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1186/s12951-017-0301-6


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[PMID]:28562031
[Au] Autor:Dantas de Araujo A; Wu C; Wu KC; Reid RC; Durek T; Lim J; Fairlie DP
[Ad] Endereço:Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, ‡Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, and §Centre for Inflammation Disease Research, The University of Queensland , Brisbane, Queensland 40
[Ti] Título:Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor.
[So] Source:Bioconjug Chem;28(6):1669-1676, 2017 Jun 21.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime. Competing instead with a lanthanide-based fluorescent ligand is more attractive due to greater longevity, stability, and safety. Here, we have chemically synthesized the 77 residue human C3a protein and conjugated its N-terminus to europium diethylenetriaminepentaacetate to produce a novel fluorescent protein (Eu-DTPA-hC3a). Time-resolved fluorescence analysis has demonstrated that Eu-DTPA-hC3a binds selectively to its cognate G protein-coupled receptor C3aR with full agonist activity and similar potency and selectivity as native C3a in inducing calcium mobilization and phosphorylation of extracellular signal-regulated kinases in HEK293 cells that stably expressed C3aR. Time-resolved fluorescence analysis for saturation and competitive binding gave a dissociation constant (K ) of 8.7 ± 1.4 nM for Eu-DTPA-hC3a and binding affinities for hC3a (pK of 8.6 ± 0.2 and K of 2.5 nM) and C3aR ligands TR16 (pK of 6.8 ± 0.1 and K of 138 nM), BR103 (pK of 6.7 ± 0.1 and K of 185 nM), BR111 (pK of 6.3 ± 0.2 and K of 544 nM) and SB290157 (pK of 6.3 ± 0.1 and K of 517 nM) via displacement of Eu-DTPA-hC3a from hC3aR. The macromolecular conjugate Eu-DTPA-hC3a is a novel nonradioactive probe suitable for studying ligand-C3aR interactions with potential value in accelerating drug development for human C3aR in physiology and disease.
[Mh] Termos MeSH primário: Complemento C3a/química
Európio/química
Corantes Fluorescentes/química
Receptores de Complemento/análise
[Mh] Termos MeSH secundário: Sinalização do Cálcio
Linhagem Celular
Seres Humanos
Ligantes
Fosforilação
Ligação Proteica
Receptores de Complemento/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); 0 (Ligands); 0 (Receptors, Complement); 0 (complement C3a receptor); 444W947O8O (Europium); 80295-42-7 (Complement C3a)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00132


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[PMID]:28482148
[Au] Autor:Golec P; Zelechowska K; Karczewska-Golec J; Karczewski J; Lesniewski A; Los M; Wegrzyn G; Klonkowski AM
[Ad] Endereço:Laboratory of Molecular Biology (affiliated with the University of Gdansk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences , Pawinskiego 5a, 02-106 Warszawa, Poland.
[Ti] Título:Bacteriophages as Factories for Eu O Nanoparticle Synthesis.
[So] Source:Bioconjug Chem;28(7):1834-1841, 2017 Jul 19.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of phage display to identify peptides with an ability to bind and synthesize Eu O nanoparticles is demonstrated in this report. This is the first report of modified phages specifically binding a lanthanide. The peptides exposed on virions revealed very strong binding to Eu O nanoparticles and the ability to catalyze Eu O nanoparticles' formation from Eu(OH) and Eu(NO ) solutions. The luminescence emission spectrum of Eu ions indicated that these ions existed mostly in sites deviated from the inversion symmetry in crystalline Eu O aggregates and gelatinous Eu(OH) precipitate. The ability of phage-displayed peptides to catalyze formation of Eu O nanoparticles provides a useful tool for a low-cost and effective synthesis of lanthanide nanoparticles, which serve as attractive biomedical sensors or fluorescent labels, among their other applications.
[Mh] Termos MeSH primário: Bacteriófagos/metabolismo
Európio/química
Nanopartículas/química
Biblioteca de Peptídeos
[Mh] Termos MeSH secundário: Catálise
Európio/metabolismo
Hidróxidos
Nanopartículas/metabolismo
Nitratos
Peptídeos
Vírion/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxides); 0 (Nitrates); 0 (Peptide Library); 0 (Peptides); 444W947O8O (Europium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00119


  7 / 2349 MEDLINE  
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[PMID]:28415555
[Au] Autor:Thao CTB; Huy BT; Sharipov M; Kim JI; Dao VD; Moon JY; Lee YI
[Ad] Endereço:Department of Chemistry, Changwon National University, Changwon 641-773, Republic of Korea.
[Ti] Título:Yb ,Er ,Eu -codoped YVO material for bioimaging with dual mode excitation.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:990-997, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We propose an efficient bioimaging strategy using Yb ,Er ,Eu -triplet doped YVO nanoparticles which were synthesized with polymer as a template. The obtained particles possess nanoscale, uniform, and flexible excitation. The effect of Eu ions on the luminescence properties of YVO :Yb ,Er ,Eu was investigated. The upconversion mechanism of the prepared material was also discussed. The structure and optical properties of the prepared material were characterized by using X-ray diffraction (XRD), Fourier-transform IR spectroscopy (FTIR), scanning electron microscopy (SEM), Transmission electron microscopy (TEM) upconversion and photoluminescence spectra. The Commission International de I'Eclairage (CIE) chromaticity coordinates was investigated to confirm the performance of color luminescent emission. The prepared YVO :Yb ,Er ,Eu nanoparticles could be easily dispersed in water by surface modification with cysteine (Cys) and glutathione (GSH). The aqueous dispersion of the modified YVO :Yb ,Er ,Eu exhibits bright upconversion and downconversion luminescence and has been applied for bioimaging of HeLa cells. Our developed material with dual excitation offers a promising advance in bioimaging.
[Mh] Termos MeSH primário: Diagnóstico por Imagem/métodos
Érbio/química
Európio/química
Itérbio/química
Ítrio/química
[Mh] Termos MeSH secundário: Células HeLa
Seres Humanos
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
444W947O8O (Europium); 58784XQC3Y (Yttrium); 77B218D3YE (Erbium); MNQ4O4WSI1 (Ytterbium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28415493
[Au] Autor:Li X; Yi Z; Xue Z; Zeng S; Liu H
[Ad] Endereço:College of Physics and Information Science, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Hunan Normal University, Changsha 410081, Hunan, China.
[Ti] Título:Multifunctional BaYbF : Gd/Er upconversion nanoparticles for in vivo tri-modal upconversion optical, X-ray computed tomography and magnetic resonance imaging.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:510-516, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Development of high-quality upconversion nanoparticles (UCNPs) with combination of the merits of multiple molecular imaging techniques, such as, upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and magnetic resonance (MR) imaging, could significantly improve the accuracy of biological diagnosis. In this work, multifunctional BaYbF : Gd/Er (50:2mol%) UCNPs were synthesized via a solvothermal method using oleic acid (OA) as surface ligands (denoted as OA-UCNPs). The OA-UCNPs were further treated by diluted HCl to form ligand-free UCNPs (LF-UCNPs) for later bioimaging applications. The cytotoxicity assay in HeLa cells shows low cell toxicity of these LF-UCNPs. Owing to the efficient UCL of BaYbF : Gd/Er, the LF-UCNPs were successfully used as luminescent bioprobe in UCL bioimaging. And, X-ray CT imaging reveals that BaYbF : Gd/Er UCNPs can act as potential contrast agents for detection of the liver and spleen in the live mice owing to the high-Z elements (e.g., Ba, Yb, and Gd) in host matrix. Moreover, with the addition of Gd, the as-designed UCNPs exhibit additional positive contrast enhancement in T -weighted MR imaging. These findings demonstrate that BaYbF : Gd/Er UCNPs are potential candidates for tri-modal imaging.
[Mh] Termos MeSH primário: Compostos de Bário
Meios de Contraste
Európio
Fluoretos
Gadolínio
Imagem por Ressonância Magnética/métodos
Nanopartículas/química
Tomografia Computadorizada por Raios X/métodos
Itérbio
[Mh] Termos MeSH secundário: Animais
Compostos de Bário/química
Compostos de Bário/farmacologia
Meios de Contraste/química
Meios de Contraste/farmacologia
Európio/química
Európio/farmacologia
Fluoretos/química
Fluoretos/farmacologia
Gadolínio/química
Gadolínio/farmacologia
Células HeLa
Seres Humanos
Teste de Materiais
Camundongos
Itérbio/química
Itérbio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Barium Compounds); 0 (Contrast Media); 444W947O8O (Europium); AU0V1LM3JT (Gadolinium); MNQ4O4WSI1 (Ytterbium); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28415449
[Au] Autor:Antic B; Boskovic M; Nikodinovic-Runic J; Ming Y; Zhang H; Bozin ES; Jankovic D; Spasojevic V; Vranjes-Djuric S
[Ad] Endereço:Vinca Institute of Nuclear Sciences, University of Belgrade, P. O. Box 522, 11001 Belgrade, Serbia. Electronic address: bantic@vinca.rs.
[Ti] Título:Complementary approaches for the evaluation of biocompatibility of Y-labeled superparamagnetic citric acid (Fe,Er) O coated nanoparticles.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:157-164, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Magnetic nanoparticles (MNPs) are of immense interest for diagnostic and therapeutic applications in medicine. Design and development of new iron oxide-based MNPs for such applications is of rather limited breadth without reliable and sensitive methods to determine their levels in body tissues. Commonly used methods, such as ICP, are quite problematic, due to the inability to decipher the origin of the detected iron, i.e. whether it originates from the MNPs or endogenous from tissues and bodily fluids. One of the approaches to overcome this problem and to increase reliability of tracing MNPs is to partially substitute iron ions in the MNPs with Er. Here, we report on the development of citric acid coated (Fe,Er) O nanoparticles and characterization of their physico-chemical and biological properties by utilization of various complementary approaches. The synthesized MNPs had a narrow (6-7nm) size distribution, as consistently seen in atomic pair distribution function, transmission electron microscopy, and DC magnetization measurements. The particles were found to be superparamagnetic, with a pronounced maximum in measured zero-field cooled magnetization at around 90K. Reduction in saturation magnetization due to incorporation of 1.7% Er into the Fe O matrix was clearly observed. From the biological standpoint, citric acid coated (Fe,Er) O NPs were found to induce low toxicity both in human cell fibroblasts and in zebrafish (Danio rerio) embryos. Biodistribution pattern of the MNPs after intravenous administration in healthy Wistar rats was followed by the radiotracer method, revealing that Y-labeled MNPs were predominantly found in liver (75.33% ID), followed by lungs (16.70% ID) and spleen (2.83% ID). Quantitative agreement with these observations was obtained by ICP-MS elemental analysis using Er as the detected tracer. Based on the favorable physical, chemical and biological characteristics, citric acid coated (Fe,Er) O MNPs could be further considered for the potential application as a diagnostic and/or therapeutic agent. This work also demonstrates that combined application of these techniques is a promising tool for studies of pharmacokinetics of the new MNPs in complex biological systems.
[Mh] Termos MeSH primário: Ácido Cítrico
Materiais Revestidos Biocompatíveis
Európio
Compostos Férricos
Fibroblastos/metabolismo
Teste de Materiais
Nanopartículas/química
Radioisótopos de Ítrio
Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Ácido Cítrico/química
Ácido Cítrico/farmacologia
Materiais Revestidos Biocompatíveis/química
Materiais Revestidos Biocompatíveis/farmacocinética
Európio/química
Európio/farmacologia
Compostos Férricos/química
Compostos Férricos/farmacologia
Fibroblastos/citologia
Seres Humanos
Campos Magnéticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 0 (Ferric Compounds); 0 (Yttrium Radioisotopes); 1K09F3G675 (ferric oxide); 2968PHW8QP (Citric Acid); 444W947O8O (Europium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28361281
[Au] Autor:Zhu W; Liang S; Wang J; Yang Z; Zhang L; Yuan T; Xu Z; Xu H; Li P
[Ad] Endereço:Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei, 430062, China.
[Ti] Título:Europium-phenolic network coated BaGdF nanocomposites for tri-modal computed tomography/magnetic resonance/luminescence imaging.
[So] Source:J Mater Sci Mater Med;28(5):74, 2017 May.
[Is] ISSN:1573-4838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multifunctional nanocomposites based on BaGdF nanoparticles (NPs) and metal phenolic network (MPN) have been engineered as novel contrast agents for potential applications in X-ray computed tomography, magnetic resonance and luminescence imaging. The BaGdF @MPN nanocomposites were synthesized at room temperature by coating BaGdF NPs with europium-phenolic network, which was obtained by the coordination of europium (III) with tannic acid (TA). The in vitro cytotoxicity assays against HepG2 cells revealed that the BaGdF @MPN nanocomposites presented better cytocompatibility and lower cytotoxity than pure BaGdF NPs. In addition, vivid red and green luminescence can be observed by confocal laser scanning microscope (CLSM) from the BaGdF @MPN nanocomposites laden HepG2 cells under the excitation of UV (390 nm) and visible light (440 nm), respectively. The longitudinal relaxivity value (r ) of the nanocomposites was 2.457 mM s . Moreover, the nanocomoposites exhibited X-ray computed tomography (CT) and T -weighted magnetic resonance (MR) imaging capacities, and the intensities of the enhanced signals of in vitro CT and MR images were proportional to the concentrations of the nanocomposites. These results indicated that the as-prepared BaGdF @MPN nanocomposites are promising contrast agents for CT/MR/luminescence imaging.
[Mh] Termos MeSH primário: Meios de Contraste
Imagem Multimodal/métodos
Nanocompostos
[Mh] Termos MeSH secundário: Meios de Contraste/química
Európio/química
Gadolínio/química
Células Hep G2
Seres Humanos
Medições Luminescentes/métodos
Imagem por Ressonância Magnética/métodos
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Nanocompostos/química
Nanocompostos/ultraestrutura
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 444W947O8O (Europium); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171021
[Lr] Data última revisão:
171021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1007/s10856-017-5888-5



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