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[PMID]: 28745365 [Au] Autor: Li Q; Wang Z; Chen Y; Zhang G [Ad] Endereço: Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, P. R. China. wangzheng@mail.sic.ac.cn. [Ti] Título: Elemental bio-imaging of PEGylated NaYF :Yb/Tm/Gd upconversion nanoparticles in mice by laser ablation inductively coupled plasma mass spectrometry to study toxic side effects on the spleen, liver and kidneys. [So] Source: Metallomics;9(8):1150-1156, 2017 Aug 16. [Is] ISSN: 1756-591X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Rare-earth upconversion nanoparticles (UCNPs) are considered stable nanoprobes with low toxicity and deep tissue penetration. However, the increasing use of UCNPs has raised concerns about their potential toxicity in living organisms. Very few studies have reported the toxicity of UCNPs; hence, it is not possible to conclude yet that UCNPs are safe. In this study, the distribution of PEGylated NaYF :Yb/Tm/Gd nanoparticles (PEG-UCNPs) in female Balb/c mice following intravenous administration, and imaging in the spleen, liver and kidney was examined by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). PEG-UCNPs distributed primarily to the liver and spleen, with significant but lower levels being noted in the kidneys, heart, and lungs. At the sub-organ level, PEG-UCNPs mainly accumulated within the red pulp of the spleen instead of the white pulp, which indicated that PEG-UCNPs are poorly immunogenic, or not immunogenic at all. The imaging of Cu in the liver and spleen showed that the primary clearance organ for PEG-UCNPs is the liver, although they are accumulated in the spleen rather than the liver. This can be explained by the fact that excess superoxide anions produced by phagocytosis of the PEG-UCNPs need Cu-Zn-superoxide dismutase to be converted to hydrogen peroxide. From the Fe, Cu, and Zn imaging of the kidney, it was concluded that PEG-UCNPs do not exhibit nephrotoxicity. [Mh] Termos MeSH primário: Rim/efeitos dos fármacos Fígado/efeitos dos fármacos Imagem Molecular/métodos Nanopartículas/toxicidade Polietilenoglicóis/química Baço/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Feminino Fluoretos/química Fluoretos/farmacocinética Gadolínio/química Gadolínio/farmacocinética Rim/metabolismo Terapia a Laser Fígado/metabolismo Espectrometria de Massas Camundongos Camundongos Endogâmicos BALB C Nanopartículas/química Baço/metabolismo Túlio/química Túlio/farmacocinética Distribuição Tecidual Itérbio/química Itérbio/farmacocinética Ítrio/química Ítrio/farmacocinética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 30IQX730WE (Polyethylene Glycols); 58784XQC3Y (Yttrium); 8RKC5ATI4P (Thulium); AU0V1LM3JT (Gadolinium); MNQ4O4WSI1 (Ytterbium); Q80VPU408O (Fluorides) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171229 [Lr] Data última revisão: 171229 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170727 [St] Status: MEDLINE [do] DOI: 10.1039/c7mt00132k

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[PMID]: 28421294 [Au] Autor: Sun F; Zhao R; Zhu Y; Cui D; Wang X; Han B; Liang S; Liu H; Sun X; Zhao F; Xu D; Xia S [Ad] Endereço: Shanghai General Hospital, Shanghai, China. [Ti] Título: A prospective comparison of intra-arterial chemotherapy combined with intravesical chemotherapy and intravesical chemotherapy alone after transurethral resection with a thulium laser in high-risk non-muscle invasive bladder cancer. [So] Source: Cancer Chemother Pharmacol;79(6):1099-1107, 2017 Jun. [Is] ISSN: 1432-0843 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Objective To compare intra-arterial chemotherapy combined with intravesical chemotherapy with intravesical chemotherapy alone in the treatment of high-risk non-muscle invasive bladder cancer (HRBC) after thulium laser resection of a bladder tumor (TmLRBT). MATERIALS AND METHODS: From January 2009 to December 2013, 283 patients with HRBC were randomly assigned to the combined group (group A, n = 141) or intravesical chemotherapy-alone group (group B, n = 142) after TmLRBT. Intra-arterial chemotherapy was administered after initial TmLRBT, with 3 courses at 4-week intervals. Each course consisted of cisplatin (50 mg/m ) and epirubicin (30 mg/m ). Intravesical chemotherapy was administered in both groups, including an immediate 50 mg of epirubicin instillation after TmLRBT and weekly maintenance for 8 weeks, followed by monthly maintenance for 1 year. RESULTS: The recurrence rate was 29.1% (41/141) in group A and 42.9% (61/142) in group B, with a significant difference (p = 0.01). The progression rate was 15.6% (22/141) in group A and 25.3% (36/142) in group B, with a significant difference (p = 0.039). Patients with concomitant carcinoma in situ (CIS) also had a lower recurrence rate and progression rate in group A compared to those in group B (p = 0.006 and p = 0.03, respectively). On univariate and multivariate logistic regression analyses, patients with low-grade histology had a higher reccurrence-free rate. Multivariate COX analysis of tumor-related factors suggested that concomitant CIS was the only significant prognostic factor associated with poorer recurrence-free survival and progression-free survival. CONCLUSIONS: Intra-arterial chemotherapy combined with intravesical chemotherapy could reduce the risk of recurrence and progression compared to intravesical chemotherapy alone in HRBC. [Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Terapia a Laser/métodos Neoplasias da Bexiga Urinária/terapia [Mh] Termos MeSH secundário: Administração Intravesical Idoso Idoso de 80 Anos ou mais Antibióticos Antineoplásicos/administração & dosagem Antineoplásicos/administração & dosagem Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos Cisplatino/administração & dosagem Terapia Combinada Cistectomia Intervalo Livre de Doença Epirubicina/administração & dosagem Feminino Seres Humanos Injeções Intra-Arteriais Masculino Meia-Idade Recidiva Local de Neoplasia/epidemiologia Prognóstico Estudos Prospectivos Túlio Neoplasias da Bexiga Urinária/diagnóstico por imagem Neoplasias da Bexiga Urinária/cirurgia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Antibiotics, Antineoplastic); 0 (Antineoplastic Agents); 3Z8479ZZ5X (Epirubicin); 8RKC5ATI4P (Thulium); Q20Q21Q62J (Cisplatin) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170613 [Lr] Data última revisão: 170613 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170420 [St] Status: MEDLINE [do] DOI: 10.1007/s00280-017-3305-x

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[PMID]: 28168722 [Au] Autor: Wang XJ; Zhuo J; Luo GH; Zhu YP; Yu DJ; Zhao RZ; Jiang CY; Shi YF; Li H; Chen L; Hao KY; Han X; Zhao S; Bei XY; Jing YF; Xia SJ [Ad] Endereço: Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [Ti] Título: Androgen Deprivation Accelerates the Prostatic Urethra Wound Healing After Thulium Laser Resection of the Prostate by Promoting Re-Epithelialization and Regulating the Macrophage Polarization. [So] Source: Prostate;77(7):708-717, 2017 May. [Is] ISSN: 1097-0045 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Complications after a thulium laser resection of the prostate (TmLRP) are related to re-epithelialization of the prostatic urethra. Since prostate growth and development are induced by androgen, the aim of this study was to determine the role and explore the mechanism of androgen in wound healing of the prostatic urethra. METHODS: Beagles that received TmLRPs were randomly distributed into a castration group, a testosterone undecanoate (TU) group, and a control group. The prostate wound was assessed once a week using a cystoscope. Histological analysis was then carried out to study the re-epithelialization of the prostatic urethra in each group. The inflammatory response in the wound tissue and urine was also investigated. RESULTS: The healing of the prostatic urethra after a TmLRP was more rapid in the castration group and slower in the TU group than that in the control group. Castration accelerated re-epithelialization by promoting basal cell proliferation in the wound surface and beneath the wound and by accelerating the differentiation of basal cells into urothelial cells. Castration reduced the duration of the inflammatory phase and induced the conversion of M1 macrophages to M2 macrophages, thus accelerating the maturation of the wound. By contrast, androgen supplementation enhanced the inflammatory response and prolonged the inflammatory phase. Moreover, the anti-inflammatory phase was delayed and weakened. CONCLUSION: Androgen deprivation promotes re-epithelialization of the wound, regulates the inflammatory response, and accelerates wound healing of the prostatic urethra after a TmLRP. Prostate 77:708-717, 2017. © 2017 Wiley Periodicals, Inc. [Mh] Termos MeSH primário: Androgênios Complicações Intraoperatórias Próstata Testosterona/análogos & derivados Ressecção Transuretral da Próstata/efeitos adversos Uretra [Mh] Termos MeSH secundário: Androgênios/administração & dosagem Androgênios/efeitos adversos Androgênios/metabolismo Animais Modelos Animais de Doenças Cães Complicações Intraoperatórias/metabolismo Complicações Intraoperatórias/fisiopatologia Complicações Intraoperatórias/terapia Macrófagos/patologia Macrófagos/fisiologia Masculino Próstata/patologia Próstata/cirurgia Reepitelização/efeitos dos fármacos Reepitelização/fisiologia Estatística como Assunto Testosterona/administração & dosagem Testosterona/efeitos adversos Testosterona/metabolismo Túlio/farmacologia Ressecção Transuretral da Próstata/métodos Uretra/lesões Uretra/patologia Cicatrização/efeitos dos fármacos Cicatrização/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Androgens); 3XMK78S47O (Testosterone); 8RKC5ATI4P (Thulium); H16A5VCT9C (testosterone undecanoate) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170720 [Lr] Data última revisão: 170720 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170208 [St] Status: MEDLINE [do] DOI: 10.1002/pros.23301

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[PMID]: 28156134 [Au] Autor: Müllhaupt G; Abt D; Mordasini L; Köhle O; Engeler DS; Lüthi A; Sauter R; Schmid HP; Schwab C [Ad] Endereço: 1 Department of Urology, Cantonal Hospital St. Gallen , St. Gallen, Switzerland . [Ti] Título: Absorption of Irrigation Fluid During Thulium Laser Vaporization of the Prostate. [So] Source: J Endourol;31(4):380-383, 2017 Apr. [Is] ISSN: 1557-900X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To assess the prevalence and extent of irrigation fluid absorption during thulium laser vaporization of the prostate. MATERIAL AND METHODS: Fifty-four patients undergoing thulium laser vaporization of the prostate were prospectively included into the trial at a tertiary referral center. Isotonic saline containing 1% ethanol was used for intraoperative irrigation. Absorption of irrigation fluid was measured periodically during the operation using the expired breath ethanol technique. Among others, intra- and postoperative changes in biochemical and hematological laboratory findings were assessed. RESULTS: Absorption of irrigation fluid was detected in 7 out of 54 (13%) patients with a median absorption volume of 265 mL (227-615). No significant differences of intra- and postoperative blood parameters were observed between absorbers and nonabsorbers. No risk factor (i.e., age, prostate size, surgery duration, applied energy, and amount of irrigation fluid) for the occurrence of fluid absorption could be identified. CONCLUSION: Absorption of irrigation fluid also occurs during thulium laser vaporization of the prostate and should be kept in mind, especially in patients at a high cardiovascular risk. However, compared with previously assessed resection and vaporization techniques, thulium vaporization might have a favorable safety profile regarding fluid absorption. [Mh] Termos MeSH primário: Etanol/metabolismo Terapia a Laser/métodos Próstata/cirurgia Cloreto de Sódio/metabolismo Irrigação Terapêutica/métodos [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Testes Respiratórios Doenças Cardiovasculares Etanol/análise Seres Humanos Masculino Meia-Idade Complicações Pós-Operatórias/epidemiologia Estudos Prospectivos Fatores de Risco Túlio Volatilização [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 3K9958V90M (Ethanol); 451W47IQ8X (Sodium Chloride); 8RKC5ATI4P (Thulium) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170602 [Lr] Data última revisão: 170602 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170204 [St] Status: MEDLINE [do] DOI: 10.1089/end.2016.0888

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[PMID]: 28107762 [Au] Autor: Tontini GE; Neumann H; Pastorelli L; Spina L; Cavallaro F; Soriani P; Rimondi A; Bruni B; Clemente C; Fagnani F; Lagoussis P; Carmignani L; Vecchi M [Ad] Endereço: Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. [Ti] Título: Thulium laser in interventional endoscopy: animal and human studies. [So] Source: Endoscopy;49(4):365-370, 2017 Apr. [Is] ISSN: 1438-8812 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The thulium laser system (TLS) is an emerging surgical tool. The 2-µm wavelength provides a confined coagulation depth (0.2 - 0.4 mm) to reduce the potential for inadvertent injuries. For the first time ever, we assessed TLS feasibility for endoscopic hemostasis ex vivo in pigs. In addition, we performed the first in vivo hemostatic treatments in humans. Tissue damage induced by TLS using different settings and optical fibers was compared to that from argon plasma coagulation (APC) in established ex vivo animal models. Three consecutive patients with complex nonvariceal upper gastrointestinal bleedings were treated and followed up. No deep submucosal injury was observed in animal models. The TLS showed a progressive penetration depth with increased power outputs and tissue exposures but very limited vertical tissue injury (0.1 - 2.0 mm) and lateral spreading damage (0.1 - 0.3 mm and 0.2 - 0.7 mm using the 365-µm and 550-µm fibers, respectively). In vivo, endoscopic hemostasis with TLS was always successful without complications. The TLS has proven to be very precise and easy to use. This novel technique appears to be a promising tool for advanced interventional endoscopy. [Mh] Termos MeSH primário: Hemorragia Gastrointestinal/terapia Hemostase Endoscópica/métodos Lasers de Estado Sólido/uso terapêutico Neoplasias Peritoneais/complicações Túlio [Mh] Termos MeSH secundário: Idoso Animais Coagulação com Plasma de Argônio Úlcera Duodenal/complicações Endoscopia do Sistema Digestório Estudos de Viabilidade Ectasia Vascular Gástrica Antral/complicações Ectasia Vascular Gástrica Antral/terapia Mucosa Gástrica Hemorragia Gastrointestinal/etiologia Hemostase Endoscópica/efeitos adversos Hemostase Endoscópica/instrumentação Seres Humanos Terapia a Laser/instrumentação Lasers de Estado Sólido/efeitos adversos Masculino Meia-Idade Úlcera Péptica Hemorrágica/etiologia Úlcera Péptica Hemorrágica/terapia Neoplasias Peritoneais/patologia Suínos [Pt] Tipo de publicação: CASE REPORTS; COMPARATIVE STUDY; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA [Nm] Nome de substância: 8RKC5ATI4P (Thulium) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170121 [St] Status: MEDLINE [do] DOI: 10.1055/s-0042-122014

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[PMID]: 28072622 [Au] Autor: Das T; Shinto A; Kamaleshwaran KK; Banerjee S [Ad] Endereço: From the *Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, India; †Homi Bhabha National Institute, Anushaktinagar, Mumbai; ‡Department of Nuclear Medicine and PET, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu; and §Radiation Medicine Centre, Bhabha Atomic Research Centre, Trombay, Mumbai, India. [Ti] Título: 170Tm-EDTMP: A Prospective Alternative of 89SrCl2 for Theranostic Treatment of Metastatic Bone Pain. [So] Source: Clin Nucl Med;42(3):235-236, 2017 Mar. [Is] ISSN: 1536-0229 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We have earlier reported the potential of Tm-EDTMP as an alternative cost-effective radiopharmaceutical of SrCl2 for bone pain palliation application. Encouraging results obtained in the radiochemical studies and biological evaluations in animal model have prompted us to initiate the clinical study to evaluate the potential of Tm-EDTMP in human cancer patients. The serial scintigraphic images represent the whole-body scans of a patient (68 years old woman) with skeletal metastases of carcinoma of the breast origin recorded after administering 370 MBq (10 mCi) of Tm-EDTMP at different post-administration time points along with the pre-therapy images recorded with Tc-MDP in the same patient. [Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico por imagem Neoplasias da Mama/diagnóstico por imagem Dor do Câncer/diagnóstico por imagem Carcinoma/diagnóstico por imagem Compostos Organometálicos Organofosfonatos Compostos Radiofarmacêuticos [Mh] Termos MeSH secundário: Idoso Neoplasias Ósseas/secundário Neoplasias da Mama/patologia Carcinoma/patologia Feminino Seres Humanos Túlio [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (170Tm-ethylenediamine-tetramethylenephosphonic acid); 0 (Organometallic Compounds); 0 (Organophosphonates); 0 (Radiopharmaceuticals); 8RKC5ATI4P (Thulium) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170111 [St] Status: MEDLINE [do] DOI: 10.1097/RLU.0000000000001530

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[PMID]: 27987738 [Au] Autor: Yan H; Chen X; Shi J; Shi Z; Sun W; Lin Q; Wang X; Dai Z [Ad] Endereço: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China. [Ti] Título: Fabrication and evaluation of chitosan/NaYF :Yb /Tm upconversion nanoparticles composite beads based on the gelling of Pickering emulsion droplets. [So] Source: Mater Sci Eng C Mater Biol Appl;71:51-59, 2017 Feb 01. [Is] ISSN: 1873-0191 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The rare earth ion doped upconversion nanoparticles (UCNPs) synthesized by hydrophobic organic ligands possess poor solubility and low fluorescence quantum yield in aqueous media. To conquer this issue, NaYF :Yb /Tm UCNPs, synthesized by a hydrothermal method, were coated with F127 and then assembled with chitosan to fabricate the chitosan/NaYF :Yb /Tm composite beads (CS/NaYF :Yb /Tm CBs) by Pickering emulsion system. The characterization results revealed that the as-synthesized NaYF :Yb /Tm UCNPs with an average size of 20nm exhibited spherical morphology, high crystallinity and characteristic emission upconversion fluorescence with an overall blue color output. The NaYF :Yb /Tm UCNPs were successfully conjugated on the surface of chitosan beads by the gelling of emulsion droplets. The resultant CS/NaYF :Yb /Tm CBs showed good upconversion luminescent property, drug-loading capacity, release performance and excellent biocompatibility, exhibiting great potentials in targeted drug delivery and tissue engineering with potential tracking capability and lasting release performance. [Mh] Termos MeSH primário: Quitosana/química Fluoretos/química Nanopartículas/química Túlio/química Itérbio/química Ítrio/química [Mh] Termos MeSH secundário: Avaliação Pré-Clínica de Medicamentos Emulsões Nanopartículas/ultraestrutura [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Emulsions); 0 (sodium yttriumtetrafluoride); 58784XQC3Y (Yttrium); 8RKC5ATI4P (Thulium); 9012-76-4 (Chitosan); MNQ4O4WSI1 (Ytterbium); Q80VPU408O (Fluorides) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161219 [St] Status: MEDLINE

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[PMID]: 27323703 [Au] Autor: R Kadukar M; Dhoble SJ; Sahu AK; Nayar V; Sailaja S; Reddy BS [Ad] Endereço: Department of Physics, R.T.M.Nagpur University, Nagpur, 440033, Maharashtra, India. [Ti] Título: Luminescence analysis of SrGa Si O : RE (RE = Dy, Tm) phosphors. [So] Source: Luminescence;32(2):159-170, 2017 Mar. [Is] ISSN: 1522-7243 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: This article reports on the luminescence properties of rare earth (Dy and Tm )ions doped SrGa Si O phosphor were studied. SrGa Si O phosphors weresynthesizedby employing solid state reaction method.From the measured X-ray diffraction (XRD) pattern of the samplemonoclinic phase structure has been observed. Thermoluminescenceand Mechanoluminescence properties of the γ-ray irradiated samples have been studied. Photoluminescence spectra of Dy activated SrGa Si O phosphor has been measured with an excitation wavelength at 348 nm,and it shows two emission bands at 483 and 574 nm due to F  â†’  H and F  â†’  H transitions respectively. Whereas the photoluminescence spectra of Tm activated SrGa Si O phosphor has been measured with an excitation wavelength at 359 nm and it exhibits two emission bands at 454 and 472 nm due to D  â†’  F and G  â†’  H transitions respectively. In thermoluminescence study, γ-irradiatedthermoluminescence glow curve of SrGa Si O :Dy phosphor shows two well defined peaks at 293 °C (peak1)and 170 °C (peak2) whereas thermoluminescence glow curve of SrGa Si O :Tm phosphor shows peaks at 292 °C (peak1) and 184 °C (peak2) indicating that two sets of traps are being activated within the particular temperature range and the trapping parameters associated with the prominent glow peaks of SrGa Si O :Dy and SrGa Si O :Tm are calculated using Chen's peak shape and initial rise method.From the Mechanoluminescence study, only one glow peak has been observed. Copyright © 2016 John Wiley & Sons, Ltd. [Mh] Termos MeSH primário: Disprósio/análise Gálio/análise Luminescência Oxigênio/análise Estrôncio/análise Túlio/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 1D4N45714Q (Dysprosium); 8RKC5ATI4P (Thulium); CH46OC8YV4 (Gallium); S88TT14065 (Oxygen); YZS2RPE8LE (Strontium) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170421 [Lr] Data última revisão: 170421 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160622 [St] Status: MEDLINE [do] DOI: 10.1002/bio.3161

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[PMID]: 26732107 [Au] Autor: Zhuo J; Wei HB; Zhang F; Liu HT; Zhao FJ; Han BM; Sun XW; Xia SJ; Jun-Lu [Ad] Endereço: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China. [Ti] Título: Two-micrometer thulium laser resection of the prostate-tangerine technique in benign prostatic hyperplasia patients with previously negative transrectal prostate biopsy. [So] Source: Asian J Androl;19(2):244-247, 2017 Mar-Apr. [Is] ISSN: 1745-7262 [Cp] País de publicação: China [La] Idioma: eng [Ab] Resumo: The 2-µm thulium laser resection of the prostate-tangerine technique (TmLRP-TT) has been introduced as a minimally invasive treatment for benign prostatic hyperplasia (BPH). This study was undertaken to assess the clinical efficacy and safety of TmLRP-TT for the treatment of BPH patients with previously negative transrectal prostate biopsy. A prospective analysis of 51 patients with previously negative transrectal prostate biopsy who underwent surgical treatment using TmLRP-TT was performed from December 2011 to December 2013. Preoperative status, surgical details, and perioperative complications were recorded. The follow-up outcome was evaluated with subjective and objective tests at 1 and 6 months. TmLRP-TT was successfully completed in all patients. Mean prostate volume, operative duration, and catheterization time were 93.3 ± 37.9 ml, 69.5 ± 39.5 min, and 6.5 ± 1.3 days, respectively. The mean International Prostate Symptom Score, quality of life score, maximum urinary flow rate, and post-void residual urine volume changed notably at 6-month follow-up (22.5 ± 6.9 vs 6.1 ± 3.2, 4.8 ± 1.3 vs 1.1 ± 0.9, 7.3 ± 4.5 vs 18.9 ± 7.1 ml s-1 , and 148.7 ± 168.7 vs 28.4 ± 17.9 ml). Two (3.9%) patients required blood transfusion perioperatively, while 3 (5.9%) patients experienced transient hematuria postoperatively, and 2 (3.9%) patients received 3 days recatheterization due to clot retention. TmLRP-TT is a safe and effective minimally invasive technique for patients with previously negative transrectal prostate biopsy during the 6-month follow-up. This promising technology may be a feasible surgical method for previously negative transrectal prostate biopsy in the future. [Mh] Termos MeSH primário: Terapia a Laser/métodos Lasers de Estado Sólido/uso terapêutico Hiperplasia Prostática/cirurgia Túlio Ressecção Transuretral da Próstata/métodos [Mh] Termos MeSH secundário: Idoso Biópsia com Agulha de Grande Calibre Seres Humanos Masculino Meia-Idade Duração da Cirurgia Tamanho do Órgão Estudos Prospectivos Próstata/patologia Próstata/cirurgia Hiperplasia Prostática/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 8RKC5ATI4P (Thulium) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160107 [St] Status: MEDLINE [do] DOI: 10.4103/1008-682X.168790

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[PMID]: 27928808 [Au] Autor: Xie T; Lai P; Luo M; Xu Y [Ad] Endereço: Department of Urology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, People's Republic of China. [Ti] Título: The Effectiveness and Safety of Transurethral (Bipolar) Plasmakinetic Resection of Prostate Combined with Thulium Laser for Large Benign Prostatic Hyperplasia (>80ml). [So] Source: Urol J;13(6):2889-2892, 2016 12 08. [Is] ISSN: 1735-546X [Cp] País de publicação: Iran [La] Idioma: eng [Ab] Resumo: PURPOSE: To evaluate the clinical curative effect and safety of transurethral (bipolar) plasmakinetic resection of theprostate (PKRP) combined with thulium laser in the treatment of large prostates (> 80mL). MATERIALS AND METHODS: From January 2014 to December 2015, 61 patients with benign prostate hyperplasia(BPH) were treated with PKRP combined with thulium laser (n = 25) or PKRP only (n = 36). We retrospectivelyanalyzed the perioperative status of patients status during 3-month follow-up. RESULTS: There was no significant difference between the two groups before treatment (P > .05). PKRP combinedwith thulium laser was significantly superior to PKRP in terms of surgical duration, intraoperative blood loss,postoperative bladder washing time, postoperative complications and time of hospital stay (P < .05). There were nosignificant improvements at international prostatic symptom score (IPSS), quality of life (QOL), maximum flowrate (Qmax), and post-void residual (PVR) urine between two groups after 3 months (P > .05). CONCLUSION: PKRP combined with thulium laser is superior than PKRP only for better surgical duration, lessbleeding, higher efficiency and much quicker recovery. It may be a better choice for the treatment of BPH withlarge prostate (> 80mL). [Mh] Termos MeSH primário: Eletrocirurgia Terapia a Laser Hiperplasia Prostática/patologia Hiperplasia Prostática/cirurgia Ressecção Transuretral da Próstata/métodos [Mh] Termos MeSH secundário: Idoso Terapia Combinada Eletrocirurgia/efeitos adversos Seguimentos Seres Humanos Terapia a Laser/efeitos adversos Masculino Estudos Retrospectivos Túlio Ressecção Transuretral da Próstata/efeitos adversos Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 8RKC5ATI4P (Thulium) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170412 [Lr] Data última revisão: 170412 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161209 [St] Status: MEDLINE

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