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[PMID]:29465580
[Au] Autor:Höhne S; Hesse V
[Ti] Título:Standard values for gas-perfusion manometry of the esophagus.
[So] Source:Medicine (Baltimore);97(8):e9910, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The manometry with water-perfused or solid-state catheters is the predominant diagnostic procedure to detect motility disorders of the esophagus. Another method is the manometry using gas-perfused catheters. Although the high-resolution manometry is the method of first choice, the conventional manometry with helium has some advantages: the simple and hygienically unproblematic use and the absence of any artefacts by the perfusion medium compared with water-perfusion, and the considerably lower costs compared with the solid-state catheters. Every method has own normal values because of the specific pressure transmission and the design of the catheter probes. To our knowledge, normal values for gas-perfusion manometry of the esophagus have not yet been published.The esophageal manometry with helium-perfused catheters was performed in 30 healthy volunteers. The main parameters of the esophageal motility and the lower esophageal sphincter were analyzed by liquid and bolus-like swallows and compared with the previous published values in other manometric procedures.The values of the motility in the distal esophagus are consistent; the pressure of the lower esophageal sphincter is generally lower than with other methods. The distal wave amplitude and the propagation velocity are significant higher in the distal esophagus than in the middle. The perfusion medium is well tolerated by the investigated volunteers.
[Mh] Termos MeSH primário: Esôfago/fisiologia
Manometria/métodos
[Mh] Termos MeSH secundário: Adulto
Cateterismo/métodos
Esfíncter Esofágico Inferior/fisiologia
Feminino
Hélio
Seres Humanos
Masculino
Satisfação do Paciente
Perfusão
Pressão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
206GF3GB41 (Helium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009910


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[PMID]:28977037
[Au] Autor:Bjørkum AA; Oveland E; Stuhr L; Havnes MB; Berven F; Grønning M; Hope A
[Ad] Endereço:Department of Biomedical Laboratory Sciences and Chemical Engineering, Western Norway University of Applied Sciences, Bergen, Norway.
[Ti] Título:Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats.
[So] Source:PLoS One;12(10):e0185765, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Better understanding of the physiological mechanisms and neurological symptoms involved in the development of decompression sickness could contribute to improvements of diving procedures. The main objective of the present study was to determine effects on the brain proteome of fast decompression (1 bar/20 s) compared to controls (1 bar/10 min) after heliox saturation diving, using rats in a model system. The protein S100B, considered a biomarker for brain injury, was not significantly different in serum samples from one week before, immediately after, and one week after the dive. Alterations in the rat brain proteome due to fast decompression were investigated using both iontrap and orbitrap LC-MS, and 967 and 1062 proteins were quantified, respectively. Based on the significantly regulated proteins in the iontrap (56) and orbitrap (128) datasets, the networks "synaptic vesicle fusion and recycling in nerve terminals" and "translation initiation" were significantly enriched in a system biological database analysis (Metacore). Ribosomal proteins (RLA2, RS10) and the proteins hippocalcin-like protein 4 and proteasome subunit beta type-7 were significantly upregulated in both datasets. The heat shock protein 105 kDa, Rho-associated protein kinase 2 and Dynamin-1 were significantly downregulated in both datasets. Another main effect of hyperbaric fast decompression in our experiment is inhibition of endocytosis and stimulation of exocytosis of vesicles in the presynaptic nerve terminal. In addition, fast decompression affected several proteins taking parts in these two main mechanisms of synaptic strength, especially alteration in CDK5/calcineurin are associated with a broad range of neurological disorders. In summary, fast decompression after heliox saturation affected the brain proteome in a rat model for diving, potentially disturbing protein homeostasis, e.g. in synaptic vesicles, and destabilizing cytoskeletal components. Data are available via ProteomeXchange with identifier PXD006349.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Hélio
Oxigenação Hiperbárica
Proteínas do Tecido Nervoso/metabolismo
Oxigênio
Proteoma
[Mh] Termos MeSH secundário: Animais
Feminino
Espectrometria de Massas
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nerve Tissue Proteins); 0 (Proteome); 206GF3GB41 (Helium); 58933-55-4 (heliox); S88TT14065 (Oxygen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185765


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[PMID]:28768783
[Au] Autor:Refaie R; Rushton P; McGovern P; Thompson D; Serrano-Pedraza I; Rankin KS; Reed M
[Ad] Endereço:Northumbria Healthcare NHS Foundation Trust, Woodhorn Ln, Ashington, Northumberland NE63 9JJ, UK.
[Ti] Título:The effect of operating lights on laminar flow: an experimental study using neutrally buoyant helium bubbles.
[So] Source:Bone Joint J;99-B(8):1061-1066, 2017 Aug.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The interaction between surgical lighting and laminar airflow is poorly understood. We undertook an experiment to identify any effect contemporary surgical lights have on laminar flow and recommend practical strategies to limit any negative effects. MATERIALS AND METHODS: Neutrally buoyant bubbles were introduced into the surgical field of a simulated setup for a routine total knee arthroplasty in a laminar flow theatre. Patterns of airflow were observed and the number of bubbles remaining above the surgical field over time identified. Five different lighting configurations were assessed. Data were analysed using simple linear regression after logarithmic transformation. RESULTS: In the absence of surgical lights, laminar airflow was observed, bubbles were cleared rapidly and did not accumulate. If lights were placed above the surgical field laminar airflow was abolished and bubbles rose from the surgical field to the lights then circulated back to the surgical field. The value of the decay parameter (slope) of the two setups differed significantly; no light (b = -1.589) one light (b = -0.1273, p < 0.001). Two lights touching (b = -0.1191) above the surgical field had a similar effect to that of a single light (p = 0. 2719). Two lights positioned by arms outstretched had a similar effect (b = -0.1204) to two lights touching (p = 0.998) and one light (p = 0.444). When lights were separated widely (160 cm), laminar airflow was observed but the rate of clearance of the bubbles remained slower (b = -1.1165) than with no lights present (p = 0.004). CONCLUSION: Surgical lights have a significantly negative effect on laminar airflow. Lights should be positioned as far away as practicable from the surgical field to limit this effect. Cite this article: 2017;99-B:1061-6.
[Mh] Termos MeSH primário: Artroplastia do Joelho/métodos
Desinfecção/métodos
Hélio/farmacologia
Iluminação/métodos
Salas Cirúrgicas
Infecção da Ferida Cirúrgica/prevenção & controle
[Mh] Termos MeSH secundário: Ambiente Controlado
Seres Humanos
Ventilação/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
206GF3GB41 (Helium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B8.BJJ-2016-0581.R2


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[PMID]:28682350
[Au] Autor:Butler D
[Ti] Título:Qatar blockade hits helium supply.
[So] Source:Nature;547(7661):16, 2017 07 04.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Hélio/provisão & distribuição
[Mh] Termos MeSH secundário: Hélio/economia
Internacionalidade
Espectroscopia de Ressonância Magnética
Catar
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
206GF3GB41 (Helium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1038/547016a


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[PMID]:28682349
[Ti] Título:Helium should be recycled.
[So] Source:Nature;547(7661):6, 2017 07 04.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Hélio/provisão & distribuição
Espectroscopia de Ressonância Magnética/instrumentação
Reciclagem
Pesquisa
[Mh] Termos MeSH secundário: Análise Custo-Benefício
Hélio/química
Hélio/economia
Catar
Reciclagem/economia
Reciclagem/tendências
Pesquisa/economia
Volatilização
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
206GF3GB41 (Helium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1038/547006a


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[PMID]:28635028
[Au] Autor:Yu T; Cheng Y; Wang X; Tu B; Cheng N; Gong J; Bai L
[Ad] Endereço:Department of Hepatobiliary Surgery, Yongchuan Hospital, Chongqing Medical University, No. 439, Quxuanhua Road, Chongqing, China, 402160.
[Ti] Título:Gases for establishing pneumoperitoneum during laparoscopic abdominal surgery.
[So] Source:Cochrane Database Syst Rev;6:CD009569, 2017 06 21.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This is an update of the review published in 2013.Laparoscopic surgery is now widely performed to treat various abdominal diseases. Currently, carbon dioxide is the most frequently used gas for insufflation of the abdominal cavity (pneumoperitoneum). Although carbon dioxide meets most of the requirements for pneumoperitoneum, the absorption of carbon dioxide may be associated with adverse events. People with high anaesthetic risk are more likely to experience cardiopulmonary complications and adverse events, for example hypercapnia and acidosis, which has to be avoided by hyperventilation. Therefore, other gases have been introduced as alternatives to carbon dioxide for establishing pneumoperitoneum. OBJECTIVES: To assess the safety, benefits, and harms of different gases (i.e. carbon dioxide, helium, argon, nitrogen, nitrous oxide, and room air) used for establishing pneumoperitoneum in participants undergoing laparoscopic general abdominal or gynaecological pelvic surgery. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2016, Issue 9), Ovid MEDLINE (1950 to September 2016), Ovid Embase (1974 to September 2016), Science Citation Index Expanded (1970 to September 2016), Chinese Biomedical Literature Database (CBM) (1978 to September 2016), ClinicalTrials.gov (September 2016), and World Health Organization International Clinical Trials Registry Platform (September 2016). SELECTION CRITERIA: We included randomised controlled trials (RCTs) comparing different gases for establishing pneumoperitoneum in participants (irrespective of age, sex, or race) undergoing laparoscopic abdominal or gynaecological pelvic surgery under general anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors identified the trials for inclusion, collected the data, and assessed the risk of bias independently. We performed the meta-analyses using Review Manager 5. We calculated risk ratio (RR) for dichotomous outcomes (or Peto odds ratio for very rare outcomes), and mean difference (MD) or standardised mean difference (SMD) for continuous outcomes with 95% confidence intervals (CI). We used GRADE to rate the quality of evidence, MAIN RESULTS: We included nine RCTs, randomising 519 participants, comparing different gases for establishing pneumoperitoneum: nitrous oxide (three trials), helium (five trials), or room air (one trial) was compared to carbon dioxide. Three trials randomised participants to nitrous oxide pneumoperitoneum (100 participants) or carbon dioxide pneumoperitoneum (96 participants). None of the trials was at low risk of bias. There was insufficient evidence to determine the effects of nitrous oxide and carbon dioxide on cardiopulmonary complications (RR 2.00, 95% CI 0.38 to 10.43; two studies; 140 participants; very low quality of evidence), or surgical morbidity (RR 1.01, 95% CI 0.18 to 5.71; two studies; 143 participants; very low quality of evidence). There were no serious adverse events related to either nitrous oxide or carbon dioxide pneumoperitoneum (three studies; 196 participants; very low quality of evidence). We could not combine data from two trials (140 participants) which individually showed lower pain scores (a difference of about one visual analogue score on a scale of 1 to 10 with lower numbers indicating less pain) with nitrous oxide pneumoperitoneum at various time points on the first postoperative day, and this was rated asvery low quality .Four trials randomised participants to helium pneumoperitoneum (69 participants) or carbon dioxide pneumoperitoneum (75 participants) and one trial involving 33 participants did not state the number of participants in each group. None of the trials was at low risk of bias. There was insufficient evidence to determine the effects of helium or carbon dioxide on cardiopulmonary complications (RR 1.46, 95% CI 0.35 to 6.12; three studies; 128 participants; very low quality of evidence) or pain scores (visual analogue score on a scale of 1 to 10 with lower numbers indicating less pain; MD 0.49 cm, 95% CI -0.28 to 1.26; two studies; 108 participants; very low quality of evidence). There were three serious adverse events (subcutaneous emphysema) related to helium pneumoperitoneum (three studies; 128 participants; very low quality of evidence).One trial randomised participants to room air pneumoperitoneum (70 participants) or carbon dioxide pneumoperitoneum (76 participants). The trial was at unclear risk of bias. There were no cardiopulmonary complications or serious adverse events observed related to either room air or carbon dioxide pneumoperitoneum (both outcomes very low quality of evidence). The evidence of lower hospital costs and reduced pain during the first postoperative day with room air pneumoperitoneum compared with carbon dioxide pneumoperitoneum (a difference of about one visual analogue score on a scale of 1 to 10 with lower numbers indicating less pain, was rated as very low quality of evidence. AUTHORS' CONCLUSIONS: The quality of the current evidence is very low. The effects of nitrous oxide and helium pneumoperitoneum compared with carbon dioxide pneumoperitoneum are uncertain. Evidence from one trial of small sample size suggests that room air pneumoperitoneum may decrease hospital costs in people undergoing laparoscopic abdominal surgery. The safety of nitrous oxide, helium, and room air pneumoperitoneum has yet to be established.Further trials on this topic are needed, and should compare various gases (i.e. nitrous oxide, helium, argon, nitrogen, and room air) with carbon dioxide under standard pressure pneumoperitoneum with cold gas insufflation for people with high anaesthetic risk. Future trials should include outcomes such as complications, serious adverse events, quality of life, and pain.
[Mh] Termos MeSH primário: Abdome/cirurgia
Ar
Dióxido de Carbono
Hélio
Laparoscopia/métodos
Óxido Nitroso
Pneumoperitônio Artificial/métodos
[Mh] Termos MeSH secundário: Analgesia/estatística & dados numéricos
Dióxido de Carbono/efeitos adversos
Hélio/efeitos adversos
Seres Humanos
Óxido Nitroso/efeitos adversos
Pneumoperitônio Artificial/efeitos adversos
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); 206GF3GB41 (Helium); K50XQU1029 (Nitrous Oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD009569.pub3


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[PMID]:28535660
[Au] Autor:Wang M; Pan YW; Zhou ZG; Cui Y; Du KP; Li S
[Ad] Endereço:Department of Radiology, the First Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, China.
[Ti] Título:[Clinical Investigation on CT guided cryoablation for treating invasive chest wall or pleural tumors].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(5):395-399, 2017 May 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the feasibility and short-term effect of CT guided cryoablation for malignant chest wall or pleural involvement. To follow up 22 patients with chest wall or pleural involvement of various malignancies who underwent cryoablation from January 2012 to January 2015 by conducting postoperative 1-, 3- and 6-month enhanced CT, MRI or PET-CT examinations, respectively, evaluate local curative effect, and observe their progression-free survival (PFS), postoperative pain remission and complications after the cryoablation. A total of 22 patients with 27 lesions received 26 times of argon-helium cryoablation. According to the coverage situation of immediate postoperative ice balls on the lesions, they were divided into a complete coverage group (Group A with 18 patients) and a partial coverage group (Group B with 4 patients). 1 month later, 15 patients' tumors were completely ablated, and 3 had residue and thus received the second cryoablation in Group A, while all patients' tumors had residue in Group B. 3 months later, 17 patients' tumors were completely ablated, and 1 had residue and thus received another cryoablation in Group A, while all patients' residual tumors enlarged in different extent in group B. 6 months later, all lesions were ablated in group A while all patients' residual tumors enlarged in group B. For the 22 patients, their preoperative, and postoperative 1-week, 1-month, 3-month, and 6-month VAS scores were 4.95±0.57, 1.45±0.35, 1.45±0.35, 1.64±1.71, and 2.00±2.35, respectively. The differences in the preoperative, postoperative 1-week, and postoperative 1-month scores are significant statistically ( <0.05), and the difference in the postoperative 1-month and 6-month scores is also with statistical significance ( =0.03). For all patients, their post-operative 1-week, 1-month, 3-monte and 6-month pain remission rates are 90.9%(20/22), 90.9%(20/22), 86.4% (19/22)and 81.8%(18/22), respectively. With a median follow-up of 13.5 months, the median PFS is 7 months. The adverse effect after argon-helium cryoablation involved transitory worsened pain (16 cases), pleural effusion (5 cases, including 3 underwent closed drainage), fever (5 cases), and hemoptysis (3 cases). CT guided argon-helium cryoablation is a safe and effective method to treat malignant chest wall or pleural involvement.
[Mh] Termos MeSH primário: Criocirurgia/métodos
Neoplasias Pleurais/cirurgia
Cirurgia Assistida por Computador/métodos
Neoplasias Torácicas/cirurgia
Parede Torácica/cirurgia
[Mh] Termos MeSH secundário: Argônio/uso terapêutico
Intervalo Livre de Doença
Estudos de Viabilidade
Feminino
Hélio/uso terapêutico
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Neoplasia Residual
Neoplasias Pleurais/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Neoplasias Torácicas/patologia
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
206GF3GB41 (Helium); 67XQY1V3KH (Argon)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.05.015


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[PMID]:28473321
[Au] Autor:Xin Y; Cereda M; Kadlecek S; Emami K; Hamedani H; Duncan I; Rajaei J; Hughes L; Meeder N; Naji J; Profka H; Bolognese BJ; Foley JP; Podolin PL; Rizi RR
[Ad] Endereço:Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
[Ti] Título:Hyperpolarized gas diffusion MRI of biphasic lung inflation in short- and long-term emphysema models.
[So] Source:Am J Physiol Lung Cell Mol Physiol;313(2):L305-L312, 2017 Aug 01.
[Is] ISSN:1522-1504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During lung inflation, airspace dimensions are affected nonlinearly by both alveolar expansion and recruitment, potentially confounding the identification of emphysematous lung by hyperpolarized helium-3 diffusion magnetic resonance imaging (HP MRI). This study aimed to characterize lung inflation over a broad range of inflation volume and pressure values in two different models of emphysema, as well as in normal lungs. Elastase-treated rats ( = 7) and healthy controls ( = 7) were imaged with HP MRI. Gradual inflation was achieved by incremental changes to both inflation volume and airway pressure. The apparent diffusion coefficient (ADC) was measured at each level of inflation and fitted to the corresponding airway pressures as the second-order response equation, with minimizing residue (χ < 0.001). A biphasic ADC response was detected, with an initial ADC increase followed by a decrease at airway pressures >18 cmH O. Discrimination between treated and control rats was optimal when airway pressure was intermediate (between 10 and 11 cmH O). Similar findings were confirmed in mice following long-term exposure to cigarette smoke, where optimal discrimination between treated and healthy mice occurred at a similar airway pressure as in the rats. We subsequently explored the evolution of ADC measured at the intermediate inflation level in mice after prolonged smoke exposure and found a significant increase ( < 0.01) in ADC over time. Our results demonstrate that measuring ADC at intermediate inflation enhances the distinction between healthy and diseased lungs, thereby establishing a model that may improve the diagnostic accuracy of future HP gas diffusion studies.
[Mh] Termos MeSH primário: Pulmão/patologia
Enfisema Pulmonar/patologia
[Mh] Termos MeSH secundário: Animais
Imagem de Difusão por Ressonância Magnética/métodos
Modelos Animais de Doenças
Hélio/química
Camundongos
Camundongos Endogâmicos C57BL
Elastase Pancreática/administração & dosagem
Pressão
Ratos
Ratos Sprague-Dawley
Fumaça/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke); 206GF3GB41 (Helium); EC 3.4.21.36 (Pancreatic Elastase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1152/ajplung.00048.2017


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[PMID]:28471738
[Au] Autor:Horn FC; Marshall H; Collier GJ; Kay R; Siddiqui S; Brightling CE; Parra-Robles J; Wild JM
[Ad] Endereço:From the Unit of Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, C Floor, Royal Hallamshire Hospital, University of Sheffield, Glossop Rd, Sheffield S10 2JF, England (F.C.H., H.M., G.J.C., J.P., J.M.W.); Novartis, Basel, Switzerland (R.K.); Department of Respiratory
[Ti] Título:Regional Ventilation Changes in the Lung: Treatment Response Mapping by Using Hyperpolarized Gas MR Imaging as a Quantitative Biomarker.
[So] Source:Radiology;284(3):854-861, 2017 Sep.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To assess the magnitude of regional response to respiratory therapeutic agents in the lungs by using treatment response mapping (TRM) with hyperpolarized gas magnetic resonance (MR) imaging. TRM was used to quantify regional physiologic response in adults with asthma who underwent a bronchodilator challenge. Materials and Methods This study was approved by the national research ethics committee and was performed with informed consent. Imaging was performed in 20 adult patients with asthma by using hyperpolarized helium 3 ( He) ventilation MR imaging. Two sets of baseline images were acquired before inhalation of a bronchodilating agent (salbutamol 400 µg), and one set was acquired after. All images were registered for voxelwise comparison. Regional treatment response, ΔR(r), was calculated as the difference in regional gas distribution (R[r] = ratio of inhaled gas to total volume of a voxel when normalized for lung inflation volume) before and after intervention. A voxelwise activation threshold from the variability of the baseline images was applied to ΔR(r) maps. The summed global treatment response map (ΔR ) was then used as a global lung index for comparison with metrics of bronchodilator response measured by using spirometry and the global imaging metric percentage ventilated volume (%VV). Results ΔR showed significant correlation (P < .01) with changes in forced expiratory volume in 1 second (r = 0.70), forced vital capacity (r = 0.84), and %VV (r = 0.56). A significant (P < .01) positive treatment effect was detected with all metrics; however, ΔR showed a lower intersubject coefficient of variation (64%) than all of the other tests (coefficient of variation, ≥99%). Conclusion TRM provides regional quantitative information on changes in inhaled gas ventilation in response to therapy. This method could be used as a sensitive regional outcome metric for novel respiratory interventions. RSNA, 2017 Online supplemental material is available for this article.
[Mh] Termos MeSH primário: Hélio/uso terapêutico
Medidas de Volume Pulmonar/métodos
Pulmão/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Albuterol/uso terapêutico
Algoritmos
Asma/diagnóstico por imagem
Asma/tratamento farmacológico
Biomarcadores
Broncodilatadores/uso terapêutico
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Bronchodilator Agents); 206GF3GB41 (Helium); QF8SVZ843E (Albuterol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017160532


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[PMID]:28379998
[Au] Autor:Kos S; Blagus T; Cemazar M; Filipic G; Sersa G; Cvelbar U
[Ad] Endereço:Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
[Ti] Título:Safety aspects of atmospheric pressure helium plasma jet operation on skin: In vivo study on mouse skin.
[So] Source:PLoS One;12(4):e0174966, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biomedical applications of plasma require its efficacy for specific purposes and equally importantly its safety. Herein the safety aspects of cold plasma created with simple atmospheric pressure plasma jet produced with helium gas and electrode discharge are evaluated in skin damage on mouse, at different duration of exposure and gas flow rates. The extent of skin damage and treatments are systematically evaluated using stereomicroscope, labelling with fluorescent dyes, histology, infrared imaging and optical emission spectroscopy. The analyses reveal early and late skin damages as a consequence of plasma treatment, and are attributed to direct and indirect effects of plasma. The results indicate that direct skin damage progresses with longer treatment time and increasing gas flow rates which reflect changes in plasma properties. With increasing flow rates, the temperature on treated skin grows and the RONS formation rises. The direct effects were plasma treatment dependent, whereas the disclosed late-secondary effects were more independent on discharge parameters and related to diffusion of RONS species. Thermal effects and skin heating are related to plasma-coupling properties and are separated from the effects of other RONS. It is demonstrated that cumulative topical treatment with helium plasma jet could lead to skin damage. How these damages can be mitigated is discussed in order to provide guidance, when using atmospheric pressure plasma jets for skin treatments.
[Mh] Termos MeSH primário: Queimaduras Químicas/etiologia
Hélio/efeitos adversos
Gases em Plasma/efeitos adversos
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Pressão Atmosférica
Queimaduras Químicas/patologia
Feminino
Temperatura Alta/efeitos adversos
Camundongos
Camundongos Endogâmicos BALB C
Microscopia de Fluorescência
Pele/lesões
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasma Gases); 206GF3GB41 (Helium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174966



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