Base de dados : MEDLINE
Pesquisa : D01.268.956 [Categoria DeCS]
Referências encontradas : 1459 [refinar]
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[PMID]:29232589
[Au] Autor:Jezowska-Bojczuk M; Stokowa-Soltys K
[Ad] Endereço:Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland. Electronic address: malgorzata.jezowska-bojczuk@chem.uni.wroc.pl.
[Ti] Título:Peptides having antimicrobial activity and their complexes with transition metal ions.
[So] Source:Eur J Med Chem;143:997-1009, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Peptide antibiotics are produced by bacterial, mammalian, insect or plant organisms in defense against invasive microbial pathogens. Therefore, they are gaining importance as anti-infective agents. There are a number of antibiotics that require metal ions to function properly. Metal ions play a key role in their action and are involved in specific interactions with proteins, nucleic acids and other biomolecules. On the other hand, it is well known that some antimicrobial agents possess functional groups that enable them interacting with metal ions present in physiological fluids. Some findings support a hypothesis that they may alter the serum metal ions concentration in humans. Complexes usually have a higher positive charge than uncomplexed compounds. This means that they might interact more tightly with polyanionic DNA and RNA molecules. It has been shown that several metal ion complexes with antibiotics promote degradation of DNA. Some of them, such as bleomycin, form stable complexes with redox metal ions and split the nucleic acids chain via the free radicals mechanism. However, this is not a rule. For example blasticidin does not cause DNA damage. This indicates that some peptide antibiotics can be considered as ligands that effectively lower the oxidative activity of transition metal ions.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Compostos Organometálicos/farmacologia
Peptídeos/farmacologia
Elementos de Transição/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/síntese química
Antibacterianos/química
Seres Humanos
Íons/química
Íons/farmacologia
Testes de Sensibilidade Microbiana
Estrutura Molecular
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Peptídeos/síntese química
Peptídeos/química
Elementos de Transição/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Ions); 0 (Organometallic Compounds); 0 (Peptides); 0 (Transition Elements)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:28722818
[Au] Autor:Luo J; Larrosa I
[Ad] Endereço:School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, P.R. China.
[Ti] Título:C-H Carboxylation of Aromatic Compounds through CO Fixation.
[So] Source:ChemSusChem;10(17):3317-3332, 2017 Sep 11.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Carbon dioxide (CO ) represents the most abundant and accessible carbon source on Earth. Thus the ability to transform CO into valuable commodity chemicals through the construction of C-C bonds is an invaluable strategy. Carboxylic acids and derivatives, the main products obtained by carboxylation of carbon nucleophiles by reaction of CO , have wide application in pharmaceuticals and advanced materials. Among the variety of carboxylation methods currently available, the direct carboxylation of C-H bonds with CO has attracted much attention owing to advantages from a step- and atom-economical point of view. In particular, the prevalence of (hetero)aromatic carboxylic acids and derivatives among biologically active compounds has led to significant interest in the development of methods for their direct carboxylation from CO . Herein, the latest achievements in the area of direct C-H carboxylation of (hetero)aromatic compounds with CO will be discussed.
[Mh] Termos MeSH primário: Dióxido de Carbono/química
Carbono/química
Ácidos Carboxílicos/química
Hidrogênio/química
[Mh] Termos MeSH secundário: Catálise
Elementos de Transição/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Transition Elements); 142M471B3J (Carbon Dioxide); 7440-44-0 (Carbon); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701058


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[PMID]:28498333
[Au] Autor:Sousa E Silva FC; Tierno AF; Wengryniuk SE
[Ad] Endereço:Department of Chemistry, Temple University, 1901 N. 13th St., Philadelphia, PA 19122, USA. tug08706@temple.edu.
[Ti] Título:Hypervalent Iodine Reagents in High Valent Transition Metal Chemistry.
[So] Source:Molecules;22(5), 2017 May 12.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Over the last 20 years, high valent metal complexes have evolved from mere curiosities to being at the forefront of modern catalytic method development. This approach has enabled transformations complimentary to those possible via traditional manifolds, most prominently carbon-heteroatom bond formation. Key to the advancement of this chemistry has been the identification of oxidants that are capable of accessing these high oxidation state complexes. The oxidant has to be both powerful enough to achieve the desired oxidation as well as provide heteroatom ligands for transfer to the metal center; these heteroatoms are often subsequently transferred to the substrate via reductive elimination. Herein we will review the central role that hypervalent iodine reagents have played in this aspect, providing an ideal balance of versatile reactivity, heteroatom ligands, and mild reaction conditions. Furthermore, these reagents are environmentally benign, non-toxic, and relatively inexpensive compared to other inorganic oxidants. We will cover advancements in both catalysis and high valent complex isolation with a key focus on the subtle effects that oxidant choice can have on reaction outcome, as well as limitations of current reagents.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Complexos de Coordenação/síntese química
Iodo/química
Elementos de Transição/química
[Mh] Termos MeSH secundário: Catálise
Fenômenos Químicos
Indicadores e Reagentes/química
Ligantes
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Indicators and Reagents); 0 (Ligands); 0 (Transition Elements); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


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[PMID]:28478233
[Au] Autor:Singh DK; Gupta T
[Ad] Endereço:Chubu Institute for Advanced Studies, Chubu University, Kasugai-shi, Aichi, 487-8501, Japan. Electronic address: dharmendraks841@gmail.com.
[Ti] Título:Role of ammonium ion and transition metals in the formation of secondary organic aerosol and metallo-organic complex within fog processed ambient deliquescent submicron particles collected in central part of Indo-Gangetic Plain.
[So] Source:Chemosphere;181:725-737, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study we observed the role of ammonium ion (NH ) and transition metals (Fe, Mn, Cr, and Cu) present in ambient submicron particles in stabilizing and enhancing the yield of water soluble organic carbon (WSOC). A good correlation of WSOC with transition metals and NH was found (R = 0.87 and 0.71), respectively within foggy episode collected ambient PM (particles having aerodynamic diameter ≤1.0 µm) suggesting plausibleness of alternate oxidation (primarily various carbonyls into their respective organic acids, esters and other derivatives.) and aging mechanisms. Molar concentration of ammonium ion was observed to be exceeded over and above to require in neutralizing the sulphate and nitrate which further hints its role in the neutralization, stabilization and enhancement of subset of WSOC such as water soluble organic acids. Transition metals were further apportioned using enrichment factor analysis. The source of Fe, Mn, and Cr was found to be crustal and Cu was tagged to anthropogenic origin. This study also described the plausible role of significant predictors (Fe and Cu) in the secondary organic aerosol (SOA) formation through effect of Fenton chemistry. Mass-to-charge ratio of identified oxalic acid from our published recent field study (carried out from same sampling location) was used for understanding the possible metallo-organic complex with Fe supports the substantial role of Fe in SOA formation in the deliquescent submicron particles facilitated by aqueous-phase chemistry.
[Mh] Termos MeSH primário: Aerossóis/análise
Poluentes Atmosféricos/análise
Compostos de Amônio/química
Compostos Orgânicos/química
Material Particulado/análise
Elementos de Transição/química
[Mh] Termos MeSH secundário: Compostos de Amônio/análise
Índia
Nitratos/química
Compostos Orgânicos/análise
Sulfatos/química
Elementos de Transição/análise
Água/análise
Água/química
Tempo (Meteorologia)
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Air Pollutants); 0 (Ammonium Compounds); 0 (Nitrates); 0 (Organic Chemicals); 0 (Particulate Matter); 0 (Sulfates); 0 (Transition Elements); 059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


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[PMID]:28106739
[Au] Autor:Ferreira M; Bricout H; Tilloy S; Monflier E
[Ad] Endereço:University of Artois, CNRS, Centrale Lille, ENSCL, University of Lille, UMR 8181, Unité de Catalyse et de Chimie du Solide (UCCS), F-62300 Lens, France. michel.ferreira@univ-artois.fr.
[Ti] Título:Transition Metal Complexes Coordinated by Water Soluble Phosphane Ligands: How Cyclodextrins Can Alter the Coordination Sphere?
[So] Source:Molecules;22(1), 2017 Jan 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The behaviour of platinum(II) and palladium(0) complexes coordinated by various hydrosoluble monodentate phosphane ligands has been investigated by P{¹H} NMR spectroscopy in the presence of randomly methylated ß-cyclodextrin (RAME-ß-CD). This molecular receptor can have no impact on the organometallic complexes, induce the formation of phosphane low-coordinated complexes or form coordination second sphere species. These three behaviours are under thermodynamic control and are governed not only by the affinity of RAME-ß-CD for the phosphane but also by the phosphane stereoelectronic properties. When observed, the low-coordinated complexes may be formed either via a preliminary decoordination of the phosphane followed by a complexation of the free ligand by the CD or via the generation of organometallic species complexed by CD which then lead to expulsion of ligands to decrease their internal steric hindrance.
[Mh] Termos MeSH primário: Complexos de Coordenação/química
Compostos Organofosforados/química
Fosfinas/química
Ácidos Sulfônicos/química
beta-Ciclodextrinas/química
[Mh] Termos MeSH secundário: Ligantes
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Paládio/química
Platina/química
Elementos de Transição/química
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Ligands); 0 (Organophosphorus Compounds); 0 (Phosphines); 0 (Sulfonic Acids); 0 (Transition Elements); 0 (beta-Cyclodextrins); 0 (triphenylphosphine-3,3',3''-trisulfonic acid); 059QF0KO0R (Water); 49DFR088MY (Platinum); 5TWQ1V240M (Palladium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:28101682
[Au] Autor:Kumar D; Sharma N; Nair M
[Ad] Endereço:Department of Chemistry, Banasthali University, Banasthali, 304022, India. dsbchoudhary2002@gmail.com.
[Ti] Título:Synthesis, spectral and extended spectrum beta-lactamase studies of transition metal tetraaza macrocyclic complexes.
[So] Source:J Biol Inorg Chem;22(4):535-543, 2017 Jun.
[Is] ISSN:1432-1327
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Urinary tract infections commonly occur in humans due to microbial pathogens invading the urinary tract, which can bring about a range of clinical symptoms and potentially fatal sequelae. The present study is aimed at addressing the development of a new antimicrobial agent against extended spectrum beta lactamase (ESBL) producing E. coli bacteria. We have synthesised some biologically potent (NNNN) donor macrocycles (L  = dibenzo[f,n]dipyrido[3,4-b:4',3'-j][1,4,9,12]tetraazacyclohexadecine-6,11,18,23(5H,12H, 7H, 24H)-tetraone, and L  = 6,12,19,25-tetraoxo-4,6,11,12,16,18,23,24-octahydrotetrabenzo [b,g,k,p][1,5,10,14]tetra azacyclooctadecine-2,13-dicarboxylic acid) and their Ti and Zr metal complexes in alcoholic media using microwave protocol. Macrocyclic ligands were synthesised by incorporating of 3,5-diaminobenzoic acid, phthalic acid and 3,4-diaminopyridine in 1:1:1 molar ratio. The macrocyclic ligands and their metal complexes have been characterised by elemental analysis, conductance measurement, magnetic measurement and their structure configurations have been determined by various spectroscopic (FTIR, H/ C NMR, UV-Vis, LC-MS mass, XRD and TGA) techniques. [ZrL Cl ]Cl metal complex shows excellent antibacterial activity against ESBLs. A zone of inhibition and minimum inhibitory concentration was determined by McFarland and the dilution method, respectively. The spectral studies confirm the binding sites of the nitrogen atom of the macrocycles. An octahedral geometry has been assigned to the metal complexes based on the findings.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Complexos de Coordenação/farmacologia
Inibidores Enzimáticos/farmacologia
Escherichia coli/efeitos dos fármacos
beta-Lactamases/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Complexos de Coordenação/síntese química
Complexos de Coordenação/química
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Escherichia coli/metabolismo
Compostos Macrocíclicos/química
Compostos Macrocíclicos/farmacologia
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Testes de Sensibilidade Microbiana
Estrutura Molecular
Espectrofotometria Infravermelho
Espectrofotometria Ultravioleta
Relação Estrutura-Atividade
Elementos de Transição/química
Elementos de Transição/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coordination Complexes); 0 (Enzyme Inhibitors); 0 (Macrocyclic Compounds); 0 (Transition Elements); EC 3.5.2.6 (beta-Lactamases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s00775-017-1440-9


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[PMID]:28096460
[Au] Autor:Li Y; Mayer FP; Hasenhuetl PS; Burtscher V; Schicker K; Sitte HH; Freissmuth M; Sandtner W
[Ad] Endereço:From the Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University Vienna, Waehringerstrasse 13a, 1090 Vienna, Austria.
[Ti] Título:Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.
[So] Source:J Biol Chem;292(10):4235-4243, 2017 Mar 10.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human dopamine transporter (DAT) has a tetrahedral Zn -binding site. Zn -binding sites are also recognized by other first-row transition metals. Excessive accumulation of manganese or of copper can lead to parkinsonism because of dopamine deficiency. Accordingly, we examined the effect of Mn , Co , Ni , and Cu on transport-associated currents through DAT and DAT-H193K, a mutant with a disrupted Zn -binding site. All transition metals except Mn modulated the transport cycle of wild-type DAT with affinities in the low micromolar range. In this concentration range, they were devoid of any action on DAT-H193K. The active transition metals reduced the affinity of DAT for dopamine. The affinity shift was most pronounced for Cu , followed by Ni and Zn (= Co ). The extent of the affinity shift and the reciprocal effect of substrate on metal affinity accounted for the different modes of action: Ni and Cu uniformly stimulated and inhibited, respectively, the substrate-induced steady-state currents through DAT. In contrast, Zn elicited biphasic effects on transport, stimulation at 1 µm and inhibition at 10 µm A kinetic model that posited preferential binding of transition metal ions to the outward-facing apo state of DAT and a reciprocal interaction of dopamine and transition metals recapitulated all experimental findings. Allosteric activation of DAT via the Zn -binding site may be of interest to restore transport in loss-of-function mutants.
[Mh] Termos MeSH primário: Proteínas da Membrana Plasmática de Transporte de Dopamina/metabolismo
Metais/metabolismo
Elementos de Transição/metabolismo
Zinco/metabolismo
[Mh] Termos MeSH secundário: Regulação Alostérica
Sítios de Ligação
Proteínas da Membrana Plasmática de Transporte de Dopamina/química
Seres Humanos
Ligação Proteica
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dopamine Plasma Membrane Transport Proteins); 0 (Metals); 0 (Transition Elements); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.760140


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[PMID]:28040658
[Au] Autor:Weekley CM; He C
[Ad] Endereço:Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, 929 E. 57th Street, Chicago, IL 60637, USA.
[Ti] Título:Developing drugs targeting transition metal homeostasis.
[So] Source:Curr Opin Chem Biol;37:26-32, 2017 Apr.
[Is] ISSN:1879-0402
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Metal dyshomeostasis is involved in the pathogenesis and progression of diseases including cancer and neurodegenerative diseases. Metal chelators and ionophores are well known modulators of transition metal homeostasis, and a number of these molecules are in clinical trials. Metal-binding compounds are not the only drugs capable of targeting transition metal homeostasis. This review presents recent highlights in the development of chelators and ionophores for the treatment of cancer and neurodegenerative disease. Moreover, we discuss the development of small molecules that alter copper and iron homeostasis by inhibiting metal transport proteins. Finally, we consider the emergence of metal regulatory factor 1 as a drug target in diseases where it mediates zinc-induced signalling cascades leading to pathogenesis.
[Mh] Termos MeSH primário: Descoberta de Drogas/métodos
Homeostase/efeitos dos fármacos
Elementos de Transição/metabolismo
[Mh] Termos MeSH secundário: Animais
Quelantes/farmacologia
Seres Humanos
Ionóforos/farmacologia
Proteínas de Membrana Transportadoras/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Ionophores); 0 (Membrane Transport Proteins); 0 (Transition Elements)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


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[PMID]:28029780
[Au] Autor:Srivastava SS; Jamkhindikar AA; Raman R; Jobby MK; Chadalawada S; Sankaranarayanan R; Sharma Y
[Ad] Endereço:CSIR-Centre for Cellular and Molecular Biology (CCMB) , Uppal Road, Hyderabad 500 007, India.
[Ti] Título:A Transition Metal-Binding, Trimeric ßγ-Crystallin from Methane-Producing Thermophilic Archaea, Methanosaeta thermophila.
[So] Source:Biochemistry;56(9):1299-1310, 2017 Mar 07.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:ßγ-Crystallins are important constituents of the vertebrate eye lens, whereas in microbes, they are prevalent as Ca -binding proteins. In archaea, ßγ-crystallins are conspicuously confined to two methanogens, viz., Methanosaeta and Methanosarcina. One of these, i.e., M-crystallin from Methanosarcina acetivorans, has been shown to be a typical Ca -binding ßγ-crystallin. Here, with the aid of a high-resolution crystal structure and isothermal titration calorimetry, we report that "Methallin", a ßγ-crystallin from Methanosaeta thermophila, is a trimeric, transition metal-binding protein. It binds Fe, Ni, Co, or Zn ion with nanomolar affinity, which is consistent even at 55 °C, the optimal temperature for the methanogen's growth. At the center of the protein trimer, the metal ion is coordinated by six histidines, two from each protomer, leading to an octahedral geometry. Small-angle X-ray scattering analysis confirms that the trimer seen in the crystal lattice is a biological assembly; this assembly dissociates to monomers upon removal of the metal ion. The introduction of two histidines (S17H/S19H) into a homologous ßγ-crystallin, Clostrillin, allows it to bind nickel at the introduced site, though with micromolar affinity. However, because of the lack of a compatible interface, nickel binding could not induce trimerization, affirming that Methallin is a naturally occurring trimer for high-affinity transition metal binding. While ßγ-crystallins are known to bind Ca and form homodimers and oligomers, the transition metal-binding, trimeric Methallin is a new paradigm for ßγ-crystallins. The distinct features of Methallin, such as nickel or iron binding, are also possible imprints of biogeochemical changes during the period of its origin.
[Mh] Termos MeSH primário: Archaea/metabolismo
Multimerização Proteica
Elementos de Transição/metabolismo
beta-Cristalinas/química
beta-Cristalinas/metabolismo
gama-Cristalinas/química
gama-Cristalinas/metabolismo
[Mh] Termos MeSH secundário: Metano/biossíntese
Modelos Moleculares
Estrutura Quaternária de Proteína
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transition Elements); 0 (beta-Crystallins); 0 (gamma-Crystallins); OP0UW79H66 (Methane)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.6b00985


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[PMID]:27976855
[Au] Autor:Ackerman CM; Lee S; Chang CJ
[Ad] Endereço:Department of Chemistry, University of California , Berkeley, California 94720, United States.
[Ti] Título:Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling.
[So] Source:Anal Chem;89(1):22-41, 2017 01 03.
[Is] ISSN:1520-6882
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Imagem Molecular/métodos
Transdução de Sinais
Elementos de Transição/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Transition Elements)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1021/acs.analchem.6b04631



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde