Base de dados : MEDLINE
Pesquisa : D01.303 [Categoria DeCS]
Referências encontradas : 451 [refinar]
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[PMID]:29446579
[Au] Autor:Savchenkov MF; Efimova NV; Manueva RS; Nikolaeva LA; Shin NS
[Ti] Título:[Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment].
[So] Source:Gig Sanit;95(12):1201-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article presents results of study of the impact of iodine deficiency and technogenic fluoride on the state of the thyroid gland in children. On the example of two districts of the city of Bratsk there were executed dynamic investigations (2002 and 2012), including the estimation of the pollution of ambient air and soil by fluorine compounds, levels of iodine intake by the body, the clinical examination of children aged from 5 to 7 years d and interviewing of their parents. In the course of the medical examination there were executed: physical examination by the pediatrician, endocrinologist, ultrasound examination of the thyroid gland, the determination both of serum hormone content by radioimmunoassay and urinary excretion offluorine and iodine. Concentrations of hydrogen fluoride and a solidfluorides in ambient air led to the accumulation offluoride ion in the soil. The iodine entering with drinking water and food, was established to provide only 37.5-50% of the daily requirement of iodine. Increased fluoride ion content in urine and milk teeth in children is associated with the concentrations of the fluorine-containing pollutants in the ambient air and soil. The fluoride pollution against the background of the natural iodine deficiency was established to increase the frequency of functional and morphological disorders of the thyroid gland in children.
[Mh] Termos MeSH primário: Poluição Ambiental
Iodo
Doenças da Glândula Tireoide
[Mh] Termos MeSH secundário: Criança
Monitoramento Ambiental/métodos
Poluição Ambiental/efeitos adversos
Poluição Ambiental/análise
Poluição Ambiental/prevenção & controle
Poluição Ambiental/estatística & dados numéricos
Feminino
Compostos de Flúor/efeitos adversos
Compostos de Flúor/análise
Disparidades nos Níveis de Saúde
Seres Humanos
Iodo/análise
Iodo/deficiência
Masculino
Saúde Pública/métodos
Saúde Pública/estatística & dados numéricos
Sibéria/epidemiologia
Doenças da Glândula Tireoide/diagnóstico
Doenças da Glândula Tireoide/epidemiologia
Doenças da Glândula Tireoide/etiologia
Doenças da Glândula Tireoide/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorine Compounds); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  2 / 451 MEDLINE  
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[PMID]:29446281
[Au] Autor:Shalina TI; Nikolaeva LA; Savchenkov MF; Bykov YN; Manueva RS
[Ti] Título:[Environmental pollution with fluoride compounds and their influence on children health].
[So] Source:Gig Sanit;95(12):1133-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Data of hygienic studies of air and soil during last 20 years have confirmed their correlating relationship with the general morbidity and a group of musculoskeletal diseases in children living in cities with the technogenic pollution of the environment. Their bones were established to grow unevenly and disproportionally, in 76% of children there have been violations in the development and growth of bones. The results of X-ray examination of hand bones in children and adolescents in the Irkutsk and Shelekhov cities are presented. Significant differences in morbidity patterns among children and adolescents including an increased incidence of musculoskeletal diseases by 5.6 in children and by 12 in adolescents have been revealed.
[Mh] Termos MeSH primário: Doença Ambiental
Compostos de Flúor
Doenças Musculoesqueléticas
[Mh] Termos MeSH secundário: Adolescente
Poluentes Atmosféricos/efeitos adversos
Poluentes Atmosféricos/análise
Desenvolvimento Ósseo/efeitos dos fármacos
Osso e Ossos/diagnóstico por imagem
Criança
Saúde da Criança/normas
Saúde da Criança/estatística & dados numéricos
Pré-Escolar
Exposição Ambiental/efeitos adversos
Exposição Ambiental/análise
Exposição Ambiental/prevenção & controle
Doença Ambiental/diagnóstico
Doença Ambiental/epidemiologia
Doença Ambiental/etiologia
Doença Ambiental/prevenção & controle
Feminino
Compostos de Flúor/efeitos adversos
Compostos de Flúor/análise
Seguimentos
Seres Humanos
Masculino
Doenças Musculoesqueléticas/diagnóstico
Doenças Musculoesqueléticas/epidemiologia
Doenças Musculoesqueléticas/etiologia
Doenças Musculoesqueléticas/prevenção & controle
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Fluorine Compounds)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:28698138
[Au] Autor:Zhao Y; Guo C; Wang L; Wang S; Li X; Jiang B; Wu N; Guo S; Zhang R; Liu K; Shi D
[Ad] Endereço:Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, Qingdao 266021, China; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory
[Ti] Título:A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway.
[So] Source:Biochem Biophys Res Commun;491(1):65-71, 2017 Sep 09.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thiosemicarbazone, a class of compounds with excellent biological activity, especially antitumor activity, have attracted wide attention. In this study, a novel fluorinated thiosemicarbazone derivative, 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide (compound 1) was synthesized and its antitumor activities were further investigated on a non-small cell lung cancer cell line (A549) along with its underlying mechanisms. Compound 1 showed significant anti-proliferative activity on A549 cells, which was further proved by colony formation experiment. Compound 1 also inhibits the invasion of A549 cells in a trans-well culture system. Moreover, compound 1 markedly induced apoptosis on A549 cells, and the ratio of Bcl-2/Bax was decreased while the amount of p53, Cleaved-Caspase 3 and Cleaved-PARP expression were increased significantly. Compound 1 decreased the mitochondrial membrane potential, while the content of reactive oxygen was increased obviously. It is revealed that compound 1 mediated cell cycle arrest in G0/G1 phase by reducing G1 phase dependent proteins, CDK4 and Cyclin D1. As a result, it is indicated that compound 1 induced apoptosis on A549 cells was realized by regulating ROS-mediated mitochondria-dependent signaling pathway.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Mitocôndrias/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Tiossemicarbazonas/síntese química
[Mh] Termos MeSH secundário: Células A549
Antineoplásicos/química
Relação Dose-Resposta a Droga
Compostos de Flúor/síntese química
Compostos de Flúor/farmacologia
Seres Humanos
Mitocôndrias/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
Tiossemicarbazonas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Fluorine Compounds); 0 (Reactive Oxygen Species); 0 (Thiosemicarbazones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28330646
[Au] Autor:Lewis CJ; Al-Mousawi A; Jha A; Allison KP
[Ad] Endereço:Department of Plastic Surgery, James Cook University Hospital, Middlesbrough, UK. Electronic address: christopher.lewis@nuth.nhs.uk.
[Ti] Título:Is it time for a change in the approach to chemical burns? The role of Diphoterine in the management of cutaneous and ocular chemical injuries.
[So] Source:J Plast Reconstr Aesthet Surg;70(5):563-567, 2017 May.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A multitude of household and occupational compounds have the potential to induce chemical burns to the eye and skin. Without prompt intervention, irreversible visual loss and disfigurement may prevail. Diphoterine and Hexafluorine are amphoteric and hypertonic chelating solutions used in the management of general chemical and hydrofluoric acid burns, respectively. They rapidly neutralise both acid and alkali agents without heat release and limit diffusion, making them superior to water irrigation alone. However, although Diphoterine and Hexafluorine uptake is slowly increasing in industrial workplaces, there is a paucity of education and use in both emergency departments and plastic surgery units worldwide. Herein, we present a case report of combined ocular and cutaneous acid burn treated with Diphoterine , together with a review of the current supporting literature.
[Mh] Termos MeSH primário: Queimaduras Químicas/tratamento farmacológico
Fármacos Dermatológicos/uso terapêutico
Queimaduras Oculares/tratamento farmacológico
Soluções Oftálmicas/uso terapêutico
Pele/lesões
[Mh] Termos MeSH secundário: Adulto
Queimaduras Químicas/etiologia
Queimaduras Oculares/induzido quimicamente
Compostos de Flúor/uso terapêutico
Seres Humanos
Masculino
Exposição Ocupacional/efeitos adversos
Compostos Orgânicos/uso terapêutico
Ácidos Sulfúricos/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dermatologic Agents); 0 (Fluorine Compounds); 0 (Ophthalmic Solutions); 0 (Organic Chemicals); 0 (Sulfuric Acids); 0 (diphoterine); 0 (hexafluorine); O40UQP6WCF (sulfuric acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


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[PMID]:27929465
[Au] Autor:Felton J; Cheng K; Said A; Shang AC; Xu S; Vivian D; Metry M; Polli JE; Raufman JP
[Ad] Endereço:Department of Surgery, University of Maryland School of Medicine.
[Ti] Título:Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport.
[So] Source:J Vis Exp;(117), 2016 Nov 27.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Along with their traditional role as detergents that facilitate fat absorption, emerging literature indicates that bile acids are potent signaling molecules that affect multiple organs; they modulate gut motility and hormone production, and alter vascular tone, glucose metabolism, lipid metabolism, and energy utilization. Changes in fecal bile acids may alter the gut microbiome and promote colon pathology including cholerrheic diarrhea and colon cancer. Key regulators of fecal bile acid composition are the small intestinal Apical Sodium-dependent Bile Acid Transporter (ASBT) and fibroblast growth factor-19 (FGF19). Reduced expression and function of ASBT decreases intestinal bile acid up-take. Moreover, in vitro data suggest that some FDA-approved drugs inhibit ASBT function. Deficient FGF19 release increases hepatic bile acid synthesis and release into the intestines to levels that overwhelm ASBT. Either ASBT dysfunction or FGF19 deficiency increases fecal bile acids and may cause chronic diarrhea and promote colon neoplasia. Regrettably, tools to measure bile acid malabsorption and the actions of drugs on bile acid transport in vivo are limited. To understand the complex actions of bile acids, techniques are required that permit simultaneous monitoring of bile acids in the gut and metabolic tissues. This led us to conceive an innovative method to measure bile acid transport in live animals using a combination of proton ( H) and fluorine ( F) magnetic resonance imaging (MRI). Novel tracers for fluorine ( F)-based live animal MRI were created and tested, both in vitro and in vivo. Strengths of this approach include the lack of exposure to ionizing radiation and translational potential for clinical research and practice.
[Mh] Termos MeSH primário: Ácidos e Sais Biliares
Transporte Biológico
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Animais
Bile
Compostos de Flúor
Seres Humanos
Intestinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Fluorine Compounds)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE
[do] DOI:10.3791/54597


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[PMID]:27054738
[Au] Autor:Fath A; Sacher F; McCaskie JE
[Ad] Endereço:University of Applied Sciences Furtwangen D-78054 Villingen-Schwenningen Germany and Hansgrohe SE 77761 Schiltach Germany.
[Ti] Título:Electrochemical decomposition of fluorinated wetting agents in plating industry waste water.
[So] Source:Water Sci Technol;73(7):1659-66, 2016.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrochemical decomposition of fluorinated surfactants (PFAS, perfluorinated alkyl substances) used in the plating industry was analyzed and the decomposition process parameters optimized at the laboratory scale and production scale of a 500-liter reactor using lead electrodes. The method and system was successfully demonstrated under production conditions to treat PFAS) with up to 99% efficiency in the concentration range of 1,000-20,000 µg/l (1 ppm-20 ppm). The treatment also reduced hexavalent chromium (Cr(6+)) ions to trivalent chromium (Cr(3+)) ions in the wastewater. If the PFAS-containing wastewater is mixed with other wastewater streams, specifically from nickel plating drag out solution or when pH values >5, the treatment process is ineffective. For the short chain PFAS, (perfluorobutylsulfonate) the process was less efficient than C6-C8 PFAS. The process is automated and has safety procedures and controls to prevent hazards. The PFAS were decomposed to hydrogen fluoride (HF) under the strong acid electrochemical operating conditions. Analytical tests showed no evidence of organic waste products remaining from the process. Conventional alternative PFAS removal systems were tested on the waste streams and compared with each other and with the-E-destruct (electrochemical oxidation) process. For example, ion exchange resin (IX resin) treatment of wastewater to complex and remove PFAS was found to be seven times more efficient when compared to the conventional activated carbon absorption (C-treat) process. However, the E-destruct process is higher in capacity, exhibits longer service life and lower operating costs than either IX or C-treat methods for elimination of PFAS from these electroplating waste streams.
[Mh] Termos MeSH primário: Técnicas Eletroquímicas
Compostos de Flúor/química
Resíduos Industriais/análise
Águas Residuais/química
Poluentes Químicos da Água/química
Agentes Molhantes/química
[Mh] Termos MeSH secundário: Cromo
Galvanoplastia
Resinas de Troca Iônica/química
Níquel
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fluorine Compounds); 0 (Industrial Waste); 0 (Ion Exchange Resins); 0 (Waste Water); 0 (Water Pollutants, Chemical); 0 (Wetting Agents); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160408
[Lr] Data última revisão:
160408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2015.650


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[PMID]:26809479
[Au] Autor:Bossi R; Vorkamp K; Skov H
[Ad] Endereço:Department of Environmental Science, Arctic Research Center, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark. Electronic address: rbo@envs.au.dk.
[Ti] Título:Concentrations of organochlorine pesticides, polybrominated diphenyl ethers and perfluorinated compounds in the atmosphere of North Greenland.
[So] Source:Environ Pollut;217:4-10, 2016 Oct.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Atmospheric concentrations of organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs) and neutral per- and polyfluoroalkyl substances (PFAS) have been measured at Villum Research Station, Station Nord (North Greenland) in the period 2008-2013. Atmospheric concentrations of OCPs at the same site have been previously reported for the years 2008-2010. The detection frequency and the average concentrations of OCPs have not significantly changed since the previous study. PBDE congeners (∑13PBDEs) were measured for the first time in North Greenland at concentrations similar to those observed for other remote sites, confirming that these compounds are ubiquitous in the Northern Hemisphere. The ∑13PBDEs concentration ranged from not detected (n.d.) to 6.26 pg m(-3). The BDE congeners found in more than 30% of the samples were BDE-17, BDE-28, BDE-47, BDE-71, BDE-99 and BDE-100. Also for neutral PFAS we present for the first time a multiyear series of measurements for North Greenland. The average sum of the seven measured neutral PFAS (∑7PFAS) ranged from 1.82 to 32.1 pg m(-3). The most abundant compound was 8:2 FTOH (44% of ∑7PFAS), followed by 6:2 FTOH and 10:2 FTOH. Perfluoroalkyl sulfonamides (FOSA) and perfluoroalkyl sulfonamidoethanols (FOSE) were also detected but at much lower concentrations than FTOHs. Temporal trends were investigated for all measured compounds but no significant trend in concentration was observed. Monthly average concentrations for the six years were calculated for each compound and the seasonal variation was investigated. Some OCPs and FTOHs showed seasonal variations, and in most cases a maximum was found during summer.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/análise
Atmosfera/química
Compostos de Flúor/análise
Éteres Difenil Halogenados/análise
Hidrocarbonetos Clorados/análise
Hidrocarbonetos Fluorados/análise
Praguicidas/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Groenlândia
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Fluorine Compounds); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Chlorinated); 0 (Hydrocarbons, Fluorinated); 0 (Pesticides)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE


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[PMID]:26821469
[Au] Autor:Kawakami T; Isama K; Ikarashi Y
[Ti] Título:Particle size distribution of aerosols sprayed from household hand-pump sprays containing fluorine-based and silicone-based compounds.
[So] Source:Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku;(133):37-41, 2015.
[Is] ISSN:1343-4292
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Japan has published safety guideline on waterproof aerosol sprays. Furthermore, the Aerosol Industry Association of Japan has adopted voluntary regulations on waterproof aerosol sprays. Aerosol particles of diameter less than 10 µm are considered as "fine particles". In order to avoid acute lung injury, this size fraction should account for less than 0.6% of the sprayed aerosol particles. In contrast, the particle size distribution of aerosols released by hand-pump sprays containing fluorine-based or silicone-based compounds have not been investigated in Japan. Thus, the present study investigated the aerosol particle size distribution of 16 household hand-pump sprays. In 4 samples, the ratio of fine particles in aerosols exceeded 0.6%. This study confirmed that several hand-pump sprays available in the Japanese market can spray fine particles. Since the hand-pump sprays use water as a solvent and their ingredients may be more hydrophilic than those of aerosol sprays, the concepts related to the safety of aerosol-sprays do not apply to the hand pump sprays. Therefore, it may be required for the hand-pump spray to develop a suitable method for evaluating the toxicity and to establish the safety guideline.
[Mh] Termos MeSH primário: Compostos de Flúor/química
Produtos Domésticos
Tamanho da Partícula
Compostos de Silício/química
[Mh] Termos MeSH secundário: Lesão Pulmonar Aguda/induzido quimicamente
Aerossóis
Compostos de Flúor/toxicidade
Produtos Domésticos/toxicidade
Japão
Compostos de Silício/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Fluorine Compounds); 0 (Silicon Compounds)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:160129
[Lr] Data última revisão:
160129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE


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[PMID]:26546265
[Au] Autor:Srivastava AK; Misra N
[Ad] Endereço:Department of Physics, University of Lucknow, Lucknow, 226007, Uttar Pradesh, India.
[Ti] Título:Nonlinear optical behavior of Li n F (n = 2-5) superalkali clusters.
[So] Source:J Mol Model;21(12):305, 2015 Dec.
[Is] ISSN:0948-5023
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hyperlithiated clusters are known for their unusual bonding characteristics and lower ionization potentials. This study reports nonlinear optical (NLO) properties of a series of hyperlithiated clusters, Li n F (n = 2-5) for the first time. The structures of small Li n F (n = 2-5) clusters, obtained using second order Møller-Plesset perturbative method, are found to be stable against eliminations of F, F‾, and LiF. These Li n F species are stabilized by both ionic as well as covalent interactions. Our study shows that Li n F species can be thought of as superalkali-halogen (Li n - F) clusters but belong to the class of superalkalies themselves. These clusters may also possess alkalide and/or electride characteristics due to excess electrons. The dipole moment, mean polarizability, and hyperpolarizability suggest their significant NLO responses which are explained using the highest occupied molecular orbital surfaces and TD-DFT analysis. The exceptionally large hyperpolarizability of Li2F (~10(5) a.u.) and its electride characteristics are particularly highlighted. This study may guide the researchers in the design of novel materials with significant NLO responses useful for electro-optical applications. Graphical Abstract Li2F superalkali resemble an electride in which the excess electron is pushed out by Li2 (+) moiety, leading to its high hyperpolarizability of order of 10(5) a.u.
[Mh] Termos MeSH primário: Álcalis/química
Compostos de Flúor/química
Compostos de Lítio/química
Fenômenos Ópticos
[Mh] Termos MeSH secundário: Elétrons
Íons
Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkalies); 0 (Fluorine Compounds); 0 (Ions); 0 (Lithium Compounds)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151108
[St] Status:MEDLINE
[do] DOI:10.1007/s00894-015-2849-0


  10 / 451 MEDLINE  
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[PMID]:26523333
[Au] Autor:Huchet QA; Kuhn B; Wagner B; Kratochwil NA; Fischer H; Kansy M; Zimmerli D; Carreira EM; Müller K
[Ad] Endereço:Laboratorium für Organische Chemie, ETH Zürich , Vladimir Prelog Weg 3 HCI H335, CH-8093 Zürich, Switzerland.
[Ti] Título:Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.
[So] Source:J Med Chem;58(22):9041-60, 2015 Nov 25.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The synthesis of a collection of 3-substituted indole derivatives incorporating partially fluorinated n-propyl and n-butyl groups is described along with an in-depth study of the effects of various fluorination patterns on their properties, such as lipophilicity, aqueous solubility, and metabolic stability. The experimental observations confirm predictions of a marked lipophilicity decrease imparted by a vic-difluoro unit when compared to the gem-difluoro counterparts. The data involving the comparison of the two substitution patterns is expected to benefit molecular design in medicinal chemistry and, more broadly, in life as well as materials sciences.
[Mh] Termos MeSH primário: Descoberta de Drogas/métodos
Compostos de Flúor/síntese química
Compostos de Flúor/farmacologia
[Mh] Termos MeSH secundário: Animais
Biotransformação
Química Física
Desenho de Drogas
Compostos de Flúor/farmacocinética
Halogenação
Seres Humanos
Técnicas In Vitro
Lipídeos/química
Microssomos Hepáticos/metabolismo
Estrutura Terciária de Proteína
Ratos
Solubilidade
Relação Estrutura-Atividade
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fluorine Compounds); 0 (Lipids)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151125
[Lr] Data última revisão:
151125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151103
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.5b01455



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