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[PMID]:29251484
[Au] Autor:Sahin R; Tapadia K; Sharma A
[Ti] Título:Kinetic and isotherm studies on adsorption of fluoride by limonite with batch technique.
[So] Source:J Environ Biol;37(5):919-26, 2016 09.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Fluoride in drinking water has an intense effect on bones and teeth. The concentration of fluoride >1.5 mg l-1 in drinking water is harmful for human health. In the present study the naturally occurring geomaterial limonite (Iron Ore) has been used as the adsorbent for the investigation of defluoridation capacity by Batch adsorption technique in aqueous condition. Various parameters such as contact time, adsorbent dose, adsorbate concentration, adsorbent particle size and agitation speed at room temperature (298K) and pH (7?0.3), has been optimization for the adsorption of F- onto limonite. The initial rate of the adsorption was very fast and after 120 minutes it attained equilibrium. Three known Isotherm Models (Langmuir, Freundlich and Temkin) used to study the mechanism and nature of adsorption onto the surface of limonite. The experimental results are best fitted into the Langmuir and Temkin isotherm models (R2> 0.99). The average monolayer adsorption capacity (Qm) obtained for limonite is 0.269 mg g-1. The experimental data highlights that surface sites of adsorbent (limonite) are heterogeneous in nature and fits into a heterogeneous site binding model. The kinetic study revealed that the adsorption process followed Pseudo 2nd order model. The removal efficiency of limonite for the naturally high F- water sample (4.12 mg l-1) under optimized condition obtained 66.9%. The maximum adsorption capacity Qe (F- adsorbed) at equilibrium is calculated 2.208 mg g-1. The isotherm and kinetic studies reveal that limonite can be used as an adsorbent for fluoride removal. The OH-group of limonite acts as ion exchange with F- ion confirm by Fourier Transmission-IR spectroscopy analysis (FT-IR). XRD (X-ray Refraction Dispersive) peaks also give good evidence of surface adsorption onto limonite and surface morphology by Scanning electron microscopy (SEM) image. In the future we can use this technology for fluoride removal in large scale by using limonite which is cost-effective, eco-friendly, minimal processing and easily available in the study area.
[Mh] Termos MeSH primário: Compostos Férricos/química
Fluoreto de Sódio/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Adsorção
Cinética
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Water Pollutants, Chemical); 2UA751211N (ferric hydroxide); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  2 / 6057 MEDLINE  
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[PMID]:29236285
[Au] Autor:Akimov OY; Kostenko VO
[Ti] Título:Functioning of nitric oxide cycle in gastric mucosa of rats under excessive combined intake of sodium nitrate and fluoride.
[So] Source:Ukr Biochem J;88(6):70-5, 2016 Nov-Dec.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:In the article the function of nitric oxide (·NO) cycle in rat's gastric mucosa was assessed under excessive combined chronic fluoride and nitrate intake during 30 days. It was estimated that general nitric oxide synthase activity (NOS) was increased during excessive sodium fluoride intake meanwhile influence on gene­ral nitrate reduction was not statistically significant, but general nitrite reduction was increased. General arginase activity decreased. Excessive sodium nitrate intake decreased NOS activity, but increased nitrate, nitrite reduction and general arginase activity. Combined sodium nitrate and fluoride intake increased NOS by 18.9%, nitrate reduction by 71.7%, nitrite by 161.5%, arginase activity increase by 61.4%. The highest amounts of peroxynitrite were obtained from excessive sodium fluoride intake group, excessive sodium nitrate intake showed the lowest levels and combined excessive sodium nitrate and fluoride intake levels had intermediate results. Summarizing the data obtained, the authors have made a conclusion that combined excessive sodium nitrate and fluoride intake creates optimal conditions for functioning of nitrate-nitrite reductases.
[Mh] Termos MeSH primário: Mucosa Gástrica/efeitos dos fármacos
Nitratos/administração & dosagem
Óxido Nítrico Sintase/genética
Óxido Nítrico/biossíntese
Fluoreto de Sódio/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Arginase/genética
Arginase/metabolismo
Feminino
Mucosa Gástrica/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Intubação Gastrointestinal
Masculino
Nitrato Redutase/genética
Nitrato Redutase/metabolismo
Nitratos/metabolismo
Óxido Nítrico Sintase/metabolismo
Nitritos/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrites); 31C4KY9ESH (Nitric Oxide); 8M4L3H2ZVZ (sodium nitrate); 8ZYQ1474W7 (Sodium Fluoride); EC 1.14.13.39 (Nitric Oxide Synthase); EC 1.7.99.4 (Nitrate Reductase); EC 3.5.3.1 (Arginase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.06.070


  3 / 6057 MEDLINE  
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[PMID]:29245332
[Au] Autor:Xia Y; Qi C; Zhang S; Huang Z; Chen Y
[Ad] Endereço:Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, PR China.
[Ti] Título:Elevated 18F-NaF uptake in cricoid cartilage in a patient with laryngeal carcinoma: A case report and literature review.
[So] Source:Medicine (Baltimore);96(49):e9090, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Laryngeal cancer is aggressive tumor that arises from the tissues of the larynx. Although any bone can be affected, involvement of cricoid cartilage was reported very rarely, and there has been no report of 18F-sodium fluoride positron emission tomography-computed tomography (F-NaF PET-CT) and 3D PET-CT for the evaluation of cricoid cartilage invasion. PATIENT CONCERNS: A 54-year-old male discovered a protruding mass in the right anterior neck, which had rapidly increased in size over a period of 2 months. Subsequently, hoarseness, dysphagia, and dyspnea were gradually developed. DIAGNOSES: F-FDG PET-CT demonstrated that the abnormal activity was located in a soft tissue mass, which was about 4.2 cm × 3.8 cm × 3.6 cm in largest dimension in the laryngeal cavity of supraglottic portion (SUVmax: 23.6). A swollen lymph node was revealed in the right submandibular region, which had intense FDG activity with a SUVmax of 18.4. However, there is a high uptake of F-FDG in the region near the bone, which is uncertain whether there is any skeletal invasion. NaF PET-CT and 3D PET-CT demonstrated increased uptake in the right side of cricoid cartilage (SUVmax: 13.2). The histopathologic examination confirmed squamous cell carcinoma of larynx. INTERVENTIONS: The patient underwent tracheotomy and received anti-infective treatment to relieve symptoms of dyspnea and prevent asphyxia. OUTCOMES: Clinical follow up of the patient revealed that dyspnea was significantly relieved. LESSONS: The case report shows the imaging features of cricoid cartilage invasion, including F-FDG PET/CT, 18F-sodium fluoride positron emission tomography-computed tomography (F-NaF PET-CT), and 3D PET-CT. Precise understanding of the invasion scope, accurately staging of laryngeal carcinoma, and choosing of the most suitable surgical scheme are the factors that lead to the optimal treatment of laryngeal neoplasms.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Cartilagem Cricoide/patologia
Neoplasias Laríngeas/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/diagnóstico por imagem
Carcinoma de Células Escamosas/cirurgia
Cartilagem Cricoide/diagnóstico por imagem
Fluordesoxiglucose F18
Seres Humanos
Neoplasias Laríngeas/diagnóstico por imagem
Neoplasias Laríngeas/cirurgia
Masculino
Meia-Idade
Compostos Radiofarmacêuticos
Fluoreto de Sódio
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009090


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[PMID]:28864413
[Au] Autor:Sun Z; Xue X; Zhang Y; Niu R; Wang J
[Ad] Endereço:College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China; Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China. Electronic address: sunzilong20
[Ti] Título:Effect of sodium fluoride on the sperm mitochondrial DNA in mice.
[So] Source:Biochem Biophys Res Commun;492(3):295-299, 2017 Oct 21.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies demonstrated that fluoride, as a widespread environmental pollutant, induced the reproductive toxicity at high dose. Besides the decrease of sperm characteristics like concentration, survival, and sperm motility, it was found that high fluoride induced the destructive mitochondrial ultrastructure and decreased ATP production from mitochondrial respiration. However, whether fluoride exposure can damage the mitochondrial DNA (mtDNA) of sperm is still unknown. In this study, 100 male mice were randomly divided into four groups 25 each, which were administrated with the distilled water containing 0, 25, 50 and 100 mg L NaF, respectively for 60 days. After exposure, sperm mtDNA copy number was measured by real-time PCR, mtDNA integrity by acridine orange (AO) staining, and nuclear DNA (nDNA) integrity through long PCR amplification, as well as MTCYB and MTATP6 mutations by PCR and direct sequencing. The results showed that 100 mg L NaF significantly increased sperm mtDNA copy number, and reduced nDNA integrity. There were no changes observed in mtDNA integrity, and mutations of MTCYB and MTATP6 between fluoride groups and the control group. These results indicated that along with low sperm quality, sperm mtDNA copy number is also a sensitive biomarker to reflect the sperm toxicity of fluoride.
[Mh] Termos MeSH primário: DNA Mitocondrial/efeitos dos fármacos
Fluoreto de Sódio/farmacologia
Espermatozoides/citologia
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
DNA Mitocondrial/genética
Relação Dose-Resposta a Droga
Masculino
Camundongos
Camundongos Endogâmicos ICR
Fluoreto de Sódio/administração & dosagem
Contagem de Espermatozoides
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


  5 / 6057 MEDLINE  
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[PMID]:28719878
[Au] Autor:Chen L; Ning H; Yin Z; Song X; Feng Y; Qin H; Li Y; Wang J; Ge Y; Wang W
[Ad] Endereço:Shanxi Agriculture University, Taigu, 030801, China.
[Ti] Título:The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission.
[So] Source:Chemosphere;185:589-594, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It has been reported that fluoride exposure may cause serious public health problems, particularly neurotoxicity. However, the underlying mechanisms remain unclear. This study used Neuro-2A cells to investigate the effects of fluoride on the cytoskeleton. The Neuro-2A cells were exposed to 0, 1, 2, 4 and 6 mM sodium fluoride (NaF) for 24 h. Cell viability and lactate dehydrogenase (LDH) release were examined. It was observed that exposure to NaF reduced cell viability, disrupted cellular membrane integrity, and high levels of LDH were released. The observed changes occurred in a dose response manner. Morphologic observations showed that cell became rounded and were loosely adherent following exposure to NaF. Axon spines and normal features disappeared with high dose NaF treatment. The expression of MAP2 and synaptophysin decreased, particularly at 4 mM and 6 mM (P < 0.05) for MAP2. These results corroborate the morphologic observations. The content of glutamate and NMDAR (glutamate receptor) protein were assessed to help understand the relationship between synapses and neurotransmitter release using ELISA and Western-blot. Compared with the control, glutamate and NMDAR expression declined significantly at 4 mM and 6 mM (P < 0.05) group. Finally, the ultrastructural changes observed with increasing doses of NaF were: disappearance of synapses, mitochondrial agglutination, vacuole formation, and cellular edema. Taken together, NaF exposure disrupted cellular integrity and suppressed the release of neurotransmitters, thus effecting neuronal function. These findings provide deeper insights into roles of NaF in neuron damage, which could contribute to a better understanding of fluoride-induced neurotoxicity.
[Mh] Termos MeSH primário: Citoesqueleto/efeitos dos fármacos
Fluoretos/toxicidade
Substâncias Perigosas/toxicidade
[Mh] Termos MeSH secundário: Linhagem Celular
Membrana Celular
Sobrevivência Celular/efeitos dos fármacos
Fluoretos/metabolismo
Microtúbulos
Neurônios/efeitos dos fármacos
Fosfatos
Fluoreto de Sódio/farmacologia
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances); 0 (Phosphates); 15181-43-8 (fluorophosphate); 8ZYQ1474W7 (Sodium Fluoride); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


  6 / 6057 MEDLINE  
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[PMID]:28678966
[Au] Autor:Rösing CK; Cavagni J; Gaio EJ; Muniz FWMG; Ranzan N; Oballe HJR; Friedrich SA; Severo RM; Stewart B; Zhang YP
[Ad] Endereço:Universidade Federal do Rio Grande do Sul - UFRS, Faculty of Dentistry, Department of Periodontology, Porto Alegre, RS, Brazil.
[Ti] Título:Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled randomized clinical trial.
[So] Source:Braz Oral Res;31:e47, 2017 Jul 03.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the anti-plaque and anti-gingivitis effects of two mouthwashes containing cetylpyridinium chloride (CPC), in comparison to negative control mouthwash. One hundred and twenty subjects were randomly assigned to study groups: test (0.075% CPC and 0.28% zinc lactate), positive control (0.07% CPC) and negative control mouthwash without CPC. All volunteers were examined by a calibrated examiner for the Quigley-Hein Plaque Index (Turesky modification) and Löe-Silness Gingival Index (GI). Gingival severity was also measured by the percentage of sites with positive gingival bleeding. During six weeks, oral hygiene consisted of brushing twice daily with a toothbrush and toothpaste and rising with their assigned mouthwash. Plaque and gingival parameters were assessed at baseline, after four and six weeks of product use. Statistical analyses were performed separately for plaque and gingival indices, by ANOVA, paired t-test and ANCOVA (α < 0.05). After 4 and 6 weeks, all mouthwashes groups presented statistically significant reductions in plaque and gingival parameters as compared to baseline. In comparison to the positive control, the test group presented additional reductions in dental plaque of 19.8% and 16.8%, after 4 and 6 weeks, respectively. For GI, the additional reductions in the test group were 9.7% and 14.3%, at 4 and 6 weeks, respectively. The test group showed additional reduction of 35.3% and 54.5% in the gingival severity, at week 4 and 6, respectively. It is concluded that the mouthwash containing CPC and zinc lactate presents significant anti-plaque and anti-gingivitis effects as compared to positive and negative control mouthwashes.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Cetilpiridínio/uso terapêutico
Placa Dentária/prevenção & controle
Gengivite/prevenção & controle
Antissépticos Bucais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Análise de Variância
Índice de Placa Dentária
Feminino
Gengivite/patologia
Seres Humanos
Masculino
Meia-Idade
Higiene Bucal
Índice Periodontal
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Fluoreto de Sódio/uso terapêutico
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Mouthwashes); 8ZYQ1474W7 (Sodium Fluoride); CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


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[PMID]:28672688
[Au] Autor:Zhao Y; Zhao J; Wang J; Wang J
[Ad] Endereço:Shanxi Key Laboratory of Environmental Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
[Ti] Título:Fluoride exposure changed the structure and the expressions of HSP related genes in testes of pubertal rats.
[So] Source:Chemosphere;184:1080-1088, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies have indicated that fluoride exposure damaged the male reproductive function; however, the cellular mechanism of fluoride-induced testicular toxicity is still unclear. In this study, twenty-two female pregnant Wistar rats were allotted randomly to two groups: control (deionized water) and sodium fluoride (NaF, contain F : 67.86 mg/L) groups. After delivery, the dosage was continued for 15 weeks for puppies. Twelve rats in each group were tested at 6 and 9 (pubertal); 12 and 15 (mature) weeks of age. Our results suggested that organ coefficient of epididymis was significantly decreased in the mature (12 and 15 week-old) rats. Epididymal sperm abnormality and femur fluoride concentration were increased with the concomitant decrease in sperm motility and concentration in these experimental periods. Compared to the control, in the NaF group, the seminiferous tubules of each age were reduced in terms of diameter and thickness. The sperm cells were lost and shedding and finally disappeared after 9 weeks. mRNA and protein levels of HSP27 and 90 were decreased with a concomitant increase in HSP70 and HSF mRNA and protein levels in NaF exposed rats. The mRNA and protein levels of HSP27 and HSF (only mRNA) were significantly increased in NaF treated rats at 9 and 15 weeks of age, respectively. In summary, these results emphasize that NaF induces testicular and sperm abnormalities through the involvement of HSPs especially during the pubertal period.
[Mh] Termos MeSH primário: Fluoretos/toxicidade
Proteínas de Choque Térmico/genética
Espermatozoides/efeitos dos fármacos
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Fluoretos/metabolismo
Masculino
Fosfatos
Ratos
Ratos Wistar
Túbulos Seminíferos
Fluoreto de Sódio
Espermatozoides/metabolismo
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heat-Shock Proteins); 0 (Phosphates); 15181-43-8 (fluorophosphate); 8ZYQ1474W7 (Sodium Fluoride); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


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[PMID]:28654366
[Au] Autor:Harmon SA; Perk T; Lin C; Eickhoff J; Choyke PL; Dahut WL; Apolo AB; Humm JL; Larson SM; Morris MJ; Liu G; Jeraj R
[Ad] Endereço:Stephanie A. Harmon, Timothy Perk, Christie Lin, Jens Eickhoff, Glenn Liu, and Robert Jeraj, University of Wisconsin-Madison; Glenn Liu and Robert Jeraj, Prostate Cancer Clinical Trials Consortium, Madison, WI; Peter L. Choyke, William L. Dahut, and Andrea B. Apolo, National Cancer Institute, Bethes
[Ti] Título:Quantitative Assessment of Early [ F]Sodium Fluoride Positron Emission Tomography/Computed Tomography Response to Treatment in Men With Metastatic Prostate Cancer to Bone.
[So] Source:J Clin Oncol;35(24):2829-2837, 2017 Aug 20.
[Is] ISSN:1527-7755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose [ F]Sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) is a promising radiotracer for quantitative assessment of bone metastases. This study assesses changes in early NaF PET/CT response measures in metastatic prostate cancer for correlation to clinical outcomes. Patients and Methods Fifty-six patients with metastatic castration-resistant prostate cancer (mCRPC) with osseous metastases had NaF PET/CT scans performed at baseline and after three cycles of chemotherapy (n = 16) or androgen receptor pathway inhibitors (n = 40). A novel technology, Quantitative Total Bone Imaging, was used for analysis. Global imaging metrics, including maximum standardized uptake value (SUV ) and total functional burden (SUV ), were extracted from composite lesion-level statistics for each patient and tracked throughout treatment. Progression-free survival (PFS) was calculated as a composite end point of progressive events using conventional imaging and/or physician discretion of clinical benefit; NaF imaging was not used for clinical evaluation. Cox proportional hazards regression analyses were conducted between imaging metrics and PFS. Results Functional burden (SUV ) assessed midtreatment was the strongest univariable PFS predictor (hazard ratio, 1.97; 95% CI, 1.44 to 2.71; P < .001). Classification of patients based on changes in functional burden showed stronger correlation to PFS than did the change in number of lesions. Various global imaging metrics outperformed baseline clinical markers in predicting outcome, including SUV and SUV . No differences in imaging response or PFS correlates were found for different treatment cohorts. Conclusion Quantitative total bone imaging enables comprehensive disease quantification on NaF PET/CT imaging, showing strong correlation to clinical outcomes. Total functional burden assessed after three cycles of hormonal therapy or chemotherapy was predictive of PFS for men with mCRPC. This supports ongoing development of NaF PET/CT-based imaging biomarkers in mCRPC to bone.
[Mh] Termos MeSH primário: Neoplasias Ósseas/tratamento farmacológico
Neoplasias Ósseas/secreção
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Neoplasias de Próstata Resistentes à Castração/diagnóstico por imagem
Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Antagonistas de Receptores de Andrógenos/uso terapêutico
Neoplasias Ósseas/diagnóstico por imagem
Intervalo Livre de Doença
Radioisótopos de Flúor
Seres Humanos
Masculino
Estudos Prospectivos
Neoplasias de Próstata Resistentes à Castração/patologia
Fluoreto de Sódio
Taxoides/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Androgen Receptor Antagonists); 0 (Fluorine Radioisotopes); 0 (Taxoids); 15H5577CQD (docetaxel); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1200/JCO.2017.72.2348


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[PMID]:28642564
[Au] Autor:Gugnani N; Gugnani S
[Ad] Endereço:Department of Pedodontics and Preventive Dentistry.
[Ti] Título:Remineralisation and arresting caries in children with topical fluorides.
[So] Source:Evid Based Dent;18(2):41-42, 2017 06 23.
[Is] ISSN:1476-5446
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Data sourcesThe Cochrane Library, PubMed, Embase and the ISI Web of Science.Study selectionEnglish language clinical trials in children with outcome measures including the remineralisation or arresting effect of caries by professional fluoride treatment were considered.Data extraction and synthesisTwo reviewers screened the studies and assessed risk of bias. Random effects meta-analysis was conducted.ResultsSeventeen studies were included, ten focused on remineralisation, seven on arresting carious lesions. Meta-analysis of four studies using 5% fluoride varnish found a 63.6% (95% CI; 36.0% - 91.2%) remineralisation of early enamel caries. For five studies using 38% silver diamine fluoride solution meta-analysis found 65.9% (95% CI; 41.2% - 90.7%) of caries arrested.ConclusionsProfessionally applied 5% sodium fluoride varnish shows the capability to remineralise early enamel caries in children. Silver diamine fluoride solution at 38% is effective in arresting active dentine caries. Because the number of clinical trials that studied the arresting effect of dental caries is limited, more clinical trials should be performed.
[Mh] Termos MeSH primário: Cárie Dentária
Fluoretos Tópicos
[Mh] Termos MeSH secundário: Criança
Assistência Odontológica
Fluoretos
Seres Humanos
Projetos de Pesquisa
Fluoreto de Sódio
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Fluorides, Topical); 8ZYQ1474W7 (Sodium Fluoride); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1038/sj.ebd.6401234


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Buzalaf, Marilia Afonso Rabelo
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[PMID]:28614381
[Au] Autor:Salomão PMA; Oliveira FA; Rodrigues PD; Al-Ahj LP; Gasque KCDS; Jeggle P; Buzalaf MAR; Oliveira RC; Edwardson JM; Magalhães AC
[Ad] Endereço:Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
[Ti] Título:The cytotoxic effect of TiF4 and NaF on fibroblasts is influenced by the experimental model, fluoride concentration and exposure time.
[So] Source:PLoS One;12(6):e0179471, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Titanium tetrafluoride (TiF4) has shown promising effect in preventing tooth lesions. Therefore, we compared the cytotoxicity of TiF4 with sodium fluoride (NaF) (already applied in Dentistry) considering different fluoride concentrations, pH values and experimental models. MATERIALS AND METHODS: Step 1) NIH/3T3 fibroblasts were exposed to mediums containing NaF or TiF4 (from 0.15 to 2.45% F), both at native and adjusted pH, for 6 h. Step 2) NIH/3T3 were exposed to NaF or TiF4 varnishes with 0.95, 1.95 or 2.45% F (native pH), for 6, 12 or 24 h. We applied MTT (1st and 2nd steps) and Hoescht/PI stain (2nd step) assays. Step 3) NIH/3T3 were exposed to NaF or TiF4 varnish (2.45% F), at native pH, for 6 or 12 h. The cell stiffness was measured by atomic force microscopy (AFM). RESULTS: Step 1) All cells exposed to NaF or TiF4 mediums died, regardless of the F concentration and pH. Step 2) Both varnishes, at 1.90 and 2.45% F, reduced cell viability by similar extents (33-86% at 6 h, 35-93% at 12 h, and 87-98% at 24 h) compared with control, regardless of the type of fluoride. Varnishes with 0.95% F did not differ from control. Step 3) TiF4 and NaF reduced cell stiffness to a similar extent, but only TiF4 differed from control at 6 h. CONCLUSIONS: Based on the results of the 3 experimental steps, we conclude that TiF4 and NaF have similar cytotoxicity. The cytotoxicity was dependent on F concentration and exposure time. This result gives support for testing the effect of TiF4 varnish in vivo.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Celulares/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
Fluoretos/farmacologia
Fluoreto de Sódio/farmacologia
Titânio/farmacologia
[Mh] Termos MeSH secundário: Animais
Cariostáticos/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Fibroblastos/citologia
Concentração de Íons de Hidrogênio
Camundongos
Microscopia de Força Atômica
Modelos Teóricos
Células NIH 3T3
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cariostatic Agents); 8ZYQ1474W7 (Sodium Fluoride); D1JT611TNE (Titanium); Q80VPU408O (Fluorides); T08RW8YRG1 (titanium tetrafluoride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179471



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