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Turssi, Cecília Pedroso
Texto completo SciELO Brasil
[PMID]:28273206
[Au] Autor:Ramos-Oliveira TM; Silva CV; Nunes PM; Turssi CP; Rechmann P; Freitas PM
[Ad] Endereço:Universidade de São Paulo - USP, School of Dentistry, Department of Restorative Dentistry, São Paulo, SP, Brazil.
[Ti] Título:AmF/NaF/SnCl2 solution reduces in situ enamel erosion - profilometry and cross-sectional nanoindentation analysis.
[So] Source:Braz Oral Res;31:e20, 2017 03 06.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This in situ study aimed to investigate the effect of a tin-containing fluoride solution in preventing enamel erosion. Also, its effects on the partly demineralized zone were assessed for the first time. Thirteen volunteers participated in this 2-phase study, wearing removable intra-oral appliances containing four sterilized bovine enamel slabs, for 8 days, where 2 treatment protocols were tested using samples in replicas (n = 13): CO - no treatment (negative control) and FL - AmF/NaF/SnCl2 solution (500 ppm F-, 800 ppm Sn2+, pH = 4.5). Samples were daily exposed to an erosive challenge (0.65% citric acid, pH 3.6, 4 min, 2x/day). In the 2nd phase, volunteers switched to the other treatment protocol. Samples were evaluated for surface loss using a profilometer (n = 13) and a cross-sectional nanohardness (CSNH) test (n = 13) was carried out in order to determine how deep the partly demineralized zone reaches below the erosive lesion. The data were statistically analyzed by two-way ANOVA. Erosive challenges lead to smaller enamel surface loss (p < 0.001) in the FL group when compared to group CO. Data from CSNH showed that there was no significant difference in demineralized enamel zone underneath erosion lesions between the groups. An amorphous layer could be observed on the surface of enamel treated with tin-containing solution alone. Under the experimental conditions of this in situ study, it can be concluded that AmF/NaF/SnCl2 solution prevents enamel surface loss but does not change the hardness of the partly demineralized zone near-surface enamel.
[Mh] Termos MeSH primário: Cariostáticos/uso terapêutico
Esmalte Dentário/efeitos dos fármacos
Fluoretos Tópicos/uso terapêutico
Fluoreto de Sódio/uso terapêutico
Fluoretos de Estanho/uso terapêutico
Erosão Dentária/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Anatomia Transversal
Animais
Bovinos
Feminino
Testes de Dureza
Seres Humanos
Estatísticas não Paramétricas
Propriedades de Superfície/efeitos dos fármacos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cariostatic Agents); 0 (Fluorides, Topical); 0 (Tin Fluorides); 0 (amine fluoride solution); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:27359362
[Au] Autor:Lippert F
[Ad] Endereço:Department of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, Ind., USA.
[Ti] Título:Mechanistic Observations on the Role of the Stannous Ion in Caries Lesion De- and Remineralization.
[So] Source:Caries Res;50(4):378-82, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two mechanistic, laboratory, factorial design studies were conducted to investigate the effect of the stannous ion (Sn2+) in the absence or presence of fluoride on caries lesion de- and remineralization. Study I was concerned with determining changes in mineral distribution of subsurface lesions, whereas study II investigated changes in surface hardness of surface-softened lesions as a function of pH. Study I showed that Sn2+ modulates the effects of fluoride by preventing lamination. Study II revealed that the effect of Sn2+ on rehardening is pH dependent. Neither study demonstrated synergy between Sn2+ and fluoride, yet interactions were observed. Sn2+ does interfere with remineralization to some extent although it provided acid resistance. The role of Sn2+ in the caries process is complex.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Cariostáticos/farmacologia
Fluoretos de Estanho/farmacologia
Desmineralização do Dente/microbiologia
Remineralização Dentária
[Mh] Termos MeSH secundário: Animais
Cátions Bivalentes/farmacologia
Bovinos
Cárie Dentária/microbiologia
Esmalte Dentário/efeitos dos fármacos
Esmalte Dentário/microbiologia
Fluoretos Tópicos/farmacologia
Seres Humanos
Concentração de Íons de Hidrogênio/efeitos dos fármacos
Microrradiografia
Estanho/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cariostatic Agents); 0 (Cations, Divalent); 0 (Fluorides, Topical); 0 (Tin Fluorides); 7440-31-5 (Tin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1159/000446849


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[PMID]:27337923
[Au] Autor:Yang S; Ying K; Wang F; Chen K; Zhou L; Yang Q
[Ti] Título:[Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;34(2):150-5, 2016 Apr.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: This study aims to assess the effects of desensitizing toothpaste containing stannous fluoride on dentine hypersensitivity by performing Meta-analysis of randomized controlled trials (RCT) involving the treatment of dentine hypersensitivity with stannous fluoride-containing toothpaste. METHODS: The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as CNKI, CBM, PubMed, Embase, and Cochrane Library up to January 2015. RCT of treating dentine hypersensitivity with stannous fluoride-containing toothpaste were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers. Meta-analysis was performed with RevMan 5.3 software. RESULTS: Six RCT with 494 patients (247 in the experimental group and 247 in the control group) were included. The results of Meta-analysis showed that the desensitizing effect of stannous fluoride-containing toothpaste was significantly better than that of control in tactile sensitivity test (SMD=1.41, 95% confidence interval 0.74-2.09, P<0.00001) and air blast test (SMD = -1.16, 95% confidence interval -1.84--0.48, P<0.000 01). CONCLUSION: Current evidence shows that stannous fluoride-containing toothpaste is effective in treating dentine hypersensitivity in clinic. However, due to limited sample size and lower quality of the included studies, more high quality and large-sample RCT are needed to further verify the evidence.
[Mh] Termos MeSH primário: Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/tratamento farmacológico
Fluoretos de Estanho/uso terapêutico
Cremes Dentais/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Fluoreto de Sódio
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Dentin Desensitizing Agents); 0 (Tin Fluorides); 0 (Toothpastes); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE


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[PMID]:27246229
[Au] Autor:Pini NI; Lima DA; Lovadino JR; Ganss C; Schlueter N
[Ad] Endereço:Department of Conservative and Preventive Dentistry, Dental Clinic, Justus Liebig University, Giessen, Germany.
[Ti] Título:In vitro Efficacy of Experimental Chitosan-Containing Solutions as Anti-Erosive Agents in Enamel.
[So] Source:Caries Res;50(3):337-45, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study evaluated the effect of chitosans with different viscosities, dissolved in an AmF/SnCl2 solution, against erosion or erosion/abrasion. A total of 192 specimens were assigned to 2 × 6 groups (n = 16 specimens each): negative control, 4 chitosan solutions (groups Ch50, Ch500, Ch1000, and Ch2000, with viscosity of 50, 500, 1,000, or 2,000 mPas, respectively, 0.5% chitosan, 500 ppm F-, 800 ppm Sn2+, pH 4.4), and positive control (500 ppm F-, 800 ppm Sn2+, pH 4.3). One half of the groups was demineralized (experiment 1, E1; 10 days, 6 × 2 min/day, 0.5% citric acid, pH 2.8) and exposed to solutions (2 × 2 min/day); the other half was additionally brushed (15 s, 200 g) with non-fluoridated toothpaste before solution immersion (experiment 2, E2). Treatment effects were investigated by profilometry, energy-dispersive X-ray spectroscopy and scanning electron microscopy (SEM). In E1, all the chitosan-containing solutions reduced enamel loss by 77-80%, to the same extent as the positive control, except for Ch2000 (p ≤ 0.05), which completely inhibited tissue loss by the formation of precipitates. In E2, Ch50 and Ch500 showed best performance, with approximately 60% reduction of tissue loss compared to the negative control group (p ≤ 0.05 compared to other groups). SEM analysis showed differences between negative control and the other groups but only minor differences amongst the groups treated with active agents. In both E1 and E2, treatment with active agents resulted in surface enrichment of carbon and tin compared to negative control (p ≤ 0.001); brushing removed parts of carbon and tin (p ≤ 0.001). Chitosan shows different properties under erosive and erosive/abrasive conditions. Under erosive conditions high viscosity might be helpful, whereas lower viscosity seems to be more effective in cases of chemo-mechanical challenges.
[Mh] Termos MeSH primário: Quitosana/farmacologia
Esmalte Dentário/efeitos dos fármacos
Abrasão Dentária/prevenção & controle
Desmineralização do Dente/prevenção & controle
Erosão Dentária/prevenção & controle
[Mh] Termos MeSH secundário: Ácido Cítrico/efeitos adversos
Seres Humanos
Técnicas In Vitro
Microscopia Eletrônica de Varredura
Fluoreto de Sódio/farmacologia
Espectrometria por Raios X
Fluoretos de Estanho/farmacologia
Abrasão Dentária/diagnóstico por imagem
Desmineralização do Dente/diagnóstico por imagem
Erosão Dentária/diagnóstico por imagem
Escovação Dentária/efeitos adversos
Cremes Dentais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Tin Fluorides); 0 (Toothpastes); 2968PHW8QP (Citric Acid); 8ZYQ1474W7 (Sodium Fluoride); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1159/000445758


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[PMID]:27115419
[Au] Autor:Schlueter N; Lussi A; Tolle A; Ganss C
[Ad] Endereço:Division for Cariology, Department of Operative Dentistry and Periodontology, Center for Dental Medicine, University Medical Center, Albert Ludwig University, Freiburg, Germany.
[Ti] Título:Effects of Erosion Protocol Design on Erosion/Abrasion Study Outcome and on Active Agent (NaF and SnF2) Efficacy.
[So] Source:Caries Res;50(2):170-9, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:There is no standard for testing anti-erosive/anti-abrasive agents, making the assessment and comparison of study results difficult. Factors which are varied in study designs are amongst others the erosive medium regarding concentration and pH or movement type of acid. The present study therefore investigated the impact of these factors on dimension of tissue loss and on efficacy of active agents used as anti-erosive/anti-abrasive therapeutics. In 8 experiments, consisting of 8 groups each (n = 20 each), resulting in a total of 64 groups, enamel specimens were demineralised (10 days, 6 × 2 min/day) using different acids (1, 0.5 and 0.3% citric acid at native pH 2.3, 2.5 and 2.8, respectively, and 0.3% citric acid adjusted to pH 3.6) with two different movement types (jerky or smooth). Specimens were immersed (2 × 2 min/day) in slurries of 1,450 ppm F- toothpaste (NaF), 1,450 ppm F- and 3,436 ppm Sn2+ toothpaste (NaF/SnF2), 970 ppm F- and 3,000 ppm Sn2+ gel (SnF2) or placebo, or were additionally brushed during immersion (15 s, 200 g). All groups were in between stored in a mineral salt solution. Tissue loss was determined profilometrically. Movement type, pH and concentration of acid had a substantial impact on study outcome. The combination of jerky movement and concentrated acid masked, to some extent, differences between erosive and erosive-abrasive tissue loss. The acid at low concentration (0.3%), independent of pH, was too mild to produce any tissue loss. The model with the best ability to demonstrate effects of abrasive impacts and active agents used the 1% acid concentration combined with smooth acid movements.
[Mh] Termos MeSH primário: Fluoreto de Sódio/uso terapêutico
Fluoretos de Estanho/uso terapêutico
Abrasão Dentária/prevenção & controle
Erosão Dentária/prevenção & controle
[Mh] Termos MeSH secundário: Ácido Cítrico/farmacologia
Esmalte Dentário/patologia
Seres Humanos
Concentração de Íons de Hidrogênio
Imagem Óptica
Projetos de Pesquisa
Fluoreto de Sódio/farmacologia
Estatísticas não Paramétricas
Fluoretos de Estanho/farmacologia
Abrasão Dentária/induzido quimicamente
Abrasão Dentária/terapia
Desmineralização do Dente/prevenção & controle
Erosão Dentária/induzido quimicamente
Erosão Dentária/terapia
Escovação Dentária
Cremes Dentais/farmacologia
Cremes Dentais/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tin Fluorides); 0 (Toothpastes); 2968PHW8QP (Citric Acid); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160427
[St] Status:MEDLINE
[do] DOI:10.1159/000445169


  6 / 766 MEDLINE  
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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
[PMID]:27093773
[Au] Autor:Parkinson CR; Hughes N; Hall C; Whelton H; Gallob J; Mason S
[Ti] Título:Three randomized clinical trials to assess the short-term efficacy of anhydrous 0.454% w/w stannous fluoride dentifrices for the relief of dentin hypersensitivity.
[So] Source:Am J Dent;29(1):25-32, 2016 Feb.
[Is] ISSN:0894-8275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the short-term efficacy of dentifrices containing 0.454% weight/weight (w/w) stannous fluoride applied using a focused brushing methodology for the relief of dentin hypersensitivity (DH). METHODS: Three randomized, examiner blind, controlled, two treatment arm, parallel group studies were conducted utilizing a novel application method in which, prior to brushing the whole mouth, the stannous fluoride dentifrice was applied to two sensitive teeth by focused brushing. DH was assessed with an evaporative (air) stimulus (with the Schiff Sensitivity Scale and a Visual Analogue Scale [VAS, Studies 1 and 3 only]) and a tactile stimulus (using a Yeaple Probe). Clinical assessments were made at baseline, immediately after first use of study dentifrice and after 3 and 14 days of twice daily brushing. Study 1 compared a marketed 0.454% w/w stannous fluoride dentifrice indicated for short-term DH relief to a marketed standard fluoride dentifrice (negative control). Studies 2 and 3 compared a novel anhydrous 0.454% w/w stannous fluoride dentifrice to the same negative control. RESULTS: For Studies 1, 2 and 3, 118, 113 and 120 subjects respectively were randomized to treatment and included in the intent-to-treat populations. Study 1 showed significant DH improvements in all measures for the test dentifrice compared to the negative control at Day 14. Study 2 showed significant differences in favor of the test dentifrice for all measures at all time points (Immediate, Days 3 and 14). In Study 3, treatment with both test and control dentifrices resulted in significant improvements over baseline, but there were no significant between-treatment differences. While these studies provide evidence for relief of DH with 0.454% w/w stannous fluoride dentifrices after short-term use (14 days) using a novel focused brushing methodology, the evidence, especially at the earliest time points, is inconclusive and further testing is needed. Study dentifrices were well tolerated. ClinicalTrials.gov trial registration numbers: Study 1 NCT01494649; Study 2: NCT01592851; Study 3: NCT01724008; funded by GSK Consumer Healthcare.
[Mh] Termos MeSH primário: Dentifrícios/uso terapêutico
Dessensibilizantes Dentinários/uso terapêutico
Sensibilidade da Dentina/tratamento farmacológico
Fluoretos de Estanho/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ar
Sensibilidade da Dentina/diagnóstico
Feminino
Seguimentos
Seres Humanos
Análise de Intenção de Tratamento
Masculino
Meia-Idade
Medição da Dor/métodos
Estimulação Física
Método Simples-Cego
Escovação Dentária/métodos
Tato
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dentifrices); 0 (Dentin Desensitizing Agents); 0 (Tin Fluorides)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160420
[Lr] Data última revisão:
160420
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160421
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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Cury, Jaime A
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[PMID]:27073873
[Au] Autor:Fernández CE; Fontana M; Samarian D; Cury JA; Rickard AH; González-Cabezas C
[Ad] Endereço:Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Mich., USA.
[Ti] Título:Effect of Fluoride-Containing Toothpastes on Enamel Demineralization and Streptococcus mutans Biofilm Architecture.
[So] Source:Caries Res;50(2):151-8, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study aimed to explore the effect of fluoridated toothpastes on biofilm architecture and enamel demineralization in an in vitro biofilm model. Streptococcus mutans was grown on enamel and treated with slurries of commercial toothpastes, containing SnF2 or NaF. Water and chlorhexidine were used as negative and positive controls, respectively. The developed biofilms were imaged and enamel demineralization was measured. SnF2 and NaF toothpaste treatments significantly reduced enamel demineralization, but SnF2 toothpaste was more effective. Only SnF2 toothpaste and chlorhexidine treatments caused reductions on biofilm mass and thickness. In conclusion, this biofilm model was able to differentiate the effects of the SnF2 and NaF toothpastes on biofilm architecture and enamel demineralization.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Esmalte Dentário/efeitos dos fármacos
Fluoreto de Sódio/farmacologia
Streptococcus mutans/efeitos dos fármacos
Fluoretos de Estanho/farmacologia
Desmineralização do Dente/tratamento farmacológico
Cremes Dentais/farmacologia
[Mh] Termos MeSH secundário: Animais
Biofilmes/crescimento & desenvolvimento
Bovinos
Clorexidina/farmacologia
Esmalte Dentário/microbiologia
Esmalte Dentário/patologia
Relação Dose-Resposta a Droga
Concentração de Íons de Hidrogênio
Imagem Tridimensional
Técnicas In Vitro
Microscopia Confocal
Saliva/metabolismo
Fluoreto de Sódio/administração & dosagem
Streptococcus mutans/crescimento & desenvolvimento
Fluoretos de Estanho/administração & dosagem
Desmineralização do Dente/microbiologia
Desmineralização do Dente/prevenção & controle
Cremes Dentais/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tin Fluorides); 0 (Toothpastes); 8ZYQ1474W7 (Sodium Fluoride); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE
[do] DOI:10.1159/000444888


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[PMID]:27043915
[Au] Autor:Wierichs RJ; Lausch J; Meyer-Lueckel H; Esteves-Oliveira M
[Ad] Endereço:Department of Operative Dentistry, Periodontology and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.
[Ti] Título:Re- and Demineralization Characteristics of Enamel Depending on Baseline Mineral Loss and Lesion Depth in situ.
[So] Source:Caries Res;50(2):141-50, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this double-blinded, randomized, cross-over in situ study was to evaluate the re- and demineralization characteristics of sound enamel as well as lowly and highly demineralized caries-like enamel lesions after the application of different fluoride compounds. METHODS: In each of three experimental legs of 4 weeks, 21 participants wore intraoral mandibular appliances containing 4 bovine enamel specimens (2 lowly and 2 highly demineralized). Each specimen included one sound enamel and either one lowly demineralized (7 days, pH 4.95) or one highly demineralized (21 days, pH 4.95) lesion, and was positioned 1 mm below the acrylic under a plastic mesh. The three randomly allocated treatments (application only) included the following dentifrices: (1) 1,100 ppm F as NaF, (2) 1,100 ppm F as SnF2 and (3) 0 ppm F (fluoride-free) as negative control. Differences in integrated mineral loss (x0394;x0394;Z) and lesion depth (x0394;LD) were calculated between values before and after the in situ period using transversal microradiography. RESULTS: Of the 21 participants, 6 did not complete the study and 2 were excluded due to protocol violation. Irrespectively of the treatment, higher baseline mineral loss and lesion depth led to a less pronounced change in mineral loss and lesion depth. Except for x0394;x0394;Z of the dentifrice with 0 ppm F, sound surfaces showed significantly higher x0394;x0394;Z and x0394;LD values compared with lowly and highly demineralized lesions (p < 0.05, t test). CONCLUSION: Re- and demineralization characteristics of enamel depended directly on baseline mineral loss and lesion depth. Treatment groups should therefore be well balanced with respect to baseline mineral loss and lesion depth.
[Mh] Termos MeSH primário: Densidade Óssea
Cárie Dentária/terapia
Esmalte Dentário/patologia
Desmineralização do Dente/prevenção & controle
Remineralização Dentária
Cremes Dentais/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Animais
Bovinos
Estudos Cross-Over
Cárie Dentária/patologia
Dentina/patologia
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Microrradiografia
Meia-Idade
Fluoreto de Sódio/administração & dosagem
Fluoreto de Sódio/farmacologia
Fatores de Tempo
Fluoretos de Estanho/administração & dosagem
Fluoretos de Estanho/farmacologia
Desmineralização do Dente/patologia
Cremes Dentais/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Tin Fluorides); 0 (Toothpastes); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1159/000444537


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[PMID]:27039991
[Au] Autor:Balloni S; Locci P; Lumare A; Marinucci L
[Ad] Endereço:Department of Experimental Medicine, Section of Bioscience and Medical Embryology, School of Medicine, University of Perugia, Perugia, Italy. Electronic address: stefania.balloni@libero.it.
[Ti] Título:Cytotoxicity of three commercial mouthrinses on extracellular matrix metabolism and human gingival cell behaviour.
[So] Source:Toxicol In Vitro;34:88-96, 2016 Aug.
[Is] ISSN:1879-3177
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study evaluated the effects of commercially available antiseptic mouthrinses on human gingival fibroblast and keratinocyte behaviour and metabolism. Three mouthrinses containing essential oil (EO), chlorhexidine (CHX) and amine fluoride/stannous fluoride (AFSF), were tested in an in vitro study. Human gingival fibroblasts and keratinocytes were washed with 10% or 30% concentration of the commercial mouthrinses and their effects on cell adhesion and proliferation were investigated as well as the specific gene expression of markers involved in oral mucosa metabolism. As markers of cell metabolism, type I and IV collagens, laminin, fibronectin, fibromodulin and integrins were studied with real-time PCR. Moreover, interleukin-1 secretion, one of the major pro-inflammatory cytokines, was evaluated. The results showed that CHX significantly reduced fibroblast and keratinocyte substrate adhesion capacities and CHX and EO inhibited cell proliferation better than AFSF rinse. The gene expression of several matrix components and cell adhesion receptors was downregulated in cells washed with CHX and EO compared with those washed with AFSF rinse. In conclusion, the AFSF mouthrinse does not induce or induces to a lesser extent the onset of irritation and/or cytotoxicity than CHX or EO. These findings and those of future studies will enable us to gain further insight into the clinical significance and effects of commercial mouthrinses. Pending further investigations, clinicians should be aware of the potentially adverse effects of mouthrinses and warn their patients against making improper use of these products.
[Mh] Termos MeSH primário: Fibroblastos/efeitos dos fármacos
Gengiva/citologia
Queratinócitos/efeitos dos fármacos
Antissépticos Bucais/toxicidade
[Mh] Termos MeSH secundário: Anti-Infecciosos Locais/toxicidade
Contagem de Células
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Clorexidina/toxicidade
Colágeno Tipo I/genética
Colágeno Tipo IV/genética
Matriz Extracelular/efeitos dos fármacos
Matriz Extracelular/metabolismo
Fibroblastos/metabolismo
Fibromodulina/genética
Fibronectinas/genética
Fluoretos Tópicos/toxicidade
Expressão Gênica/efeitos dos fármacos
Seres Humanos
Integrinas/genética
Interleucina-1
Queratinócitos/metabolismo
Laminina/genética
Óleos Voláteis/toxicidade
RNA Mensageiro/metabolismo
Fluoretos de Estanho/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Collagen Type I); 0 (Collagen Type IV); 0 (FMOD protein, human); 0 (Fibronectins); 0 (Fluorides, Topical); 0 (Integrins); 0 (Interleukin-1); 0 (Laminin); 0 (Mouthwashes); 0 (Oils, Volatile); 0 (RNA, Messenger); 0 (Tin Fluorides); 0 (amine fluoride solution); 126468-95-9 (Fibromodulin); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


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[PMID]:26991437
[Au] Autor:Tsopelas C
[Ad] Endereço:RAH Radiopharmacy, Royal Adelaide Hospital, Nuclear Medicine Department, Adelaide, Australia.
[Ti] Título:A study of radiogallium aqueous chemistry: in vitro and in vivo characterisation of (67) Ga-hydrolysed-stannous fluoride particles.
[So] Source:J Labelled Comp Radiopharm;59(5):197-204, 2016 May 15.
[Is] ISSN:1099-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to explore the aqueous chemistry of gallium using (67) Ga-chloride starting material, by radiolabelling hydrolysed(h)-stannous fluoride particles and then characterising the optimal formulation for radiochemical purity (RCP) and radioactive particle size distribution in vitro. The pilot reactions determined stannous fluoride was added to (67) Ga-acetate under nitrogen and then heated at 100 °C for 20 min to achieve ≥95% RCP and (67) Ga-particles were >3 µm in diameter. A high radioactive concentration of (67) Ga-h-SnF2 particles could be prepared similarly in ≥97% RCP with 74% as 3-5 µm and 26% >5 µm in diameter. The latter formulation had larger particles than (99m) Tc-h-SnF2 colloid (96% of 1-3 µm), and it resulted in a rat biodistribution of 41% in the lungs, 41% in the liver plus spleen and 18% in the carcass at 20 min after injection. The carcass activity was attributed to bone marrow and some (67) Ga-transferrin formed in blood. Isolated mixed human leucocytes were radiolabelled with (67) Ga-h-SnF2 particles in 100% efficiency, and the (67) Ga-cells did not release soluble (67) Ga(3+) at room temperature over 3 h. The (67) Ga-h-SnF2 particle formulation could find a use in labelling leucocyte cells for in vivo homing studies when delayed animal imaging is required.
[Mh] Termos MeSH primário: Radioisótopos de Gálio/química
Fluoretos de Estanho/química
Água/química
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Hidrólise
Marcação por Isótopo
Leucócitos/metabolismo
Radioquímica
Ratos
Ratos Sprague-Dawley
Tecnécio/química
Fluoretos de Estanho/metabolismo
Fluoretos de Estanho/farmacocinética
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gallium Radioisotopes); 0 (Tin Fluorides); 059QF0KO0R (Water); 7440-26-8 (Technetium)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE
[do] DOI:10.1002/jlcr.3388



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