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  1 / 5672 MEDLINE  
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[PMID]:29379007
[Au] Autor:Ye CX; Melcamu YY; Li HH; Cheng JT; Zhang TT; Ruan YP; Zheng X; Lu X; Huang PQ
[Ad] Endereço:Department of Chemistry and Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China.
[Ti] Título:Dual catalysis for enantioselective convergent synthesis of enantiopure vicinal amino alcohols.
[So] Source:Nat Commun;9(1):410, 2018 01 29.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Enantiopure vicinal amino alcohols and derivatives are essential structural motifs in natural products and pharmaceutically active molecules, and serve as main chiral sources in asymmetric synthesis. Currently known asymmetric catalytic protocols for this class of compounds are still rare and often suffer from limited scope of substrates, relatively low regio- or stereoselectivities, thus prompting the development of more effective methodologies. Herein we report a dual catalytic strategy for the convergent enantioselective synthesis of vicinal amino alcohols. The method features a radical-type Zimmerman-Traxler transition state formed from a rare earth metal with a nitrone and an aromatic ketyl radical in the presence of chiral N,N'-dioxide ligands. In addition to high level of enantio- and diastereoselectivities, our synthetic protocol affords advantages of simple operation, mild conditions, high-yielding, and a broad scope of substrates. Furthermore, this protocol has been successfully applied to the concise synthesis of pharmaceutically valuable compounds (e.g., ephedrine and selegiline).
[Mh] Termos MeSH primário: Aldeídos/química
Amino Álcoois/síntese química
Técnicas de Química Sintética
Ácidos de Lewis/química
Óxidos de Nitrogênio/química
[Mh] Termos MeSH secundário: Catálise
Luz
Oxirredução
Processos Fotoquímicos
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aldehydes); 0 (Amino Alcohols); 0 (Lewis Acids); 0 (Nitrogen Oxides); 0 (nitrones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02698-4


  2 / 5672 MEDLINE  
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[PMID]:29361219
[Au] Autor:Agostini A; Palm DM; Paulsen H; Carbonera D
[Ad] Endereço:Department of Chemical Sciences, University of Padova , Via Marzolo 1, 35131 Padova, Italy.
[Ti] Título:Accessibility of Protein-Bound Chlorophylls Probed by Dynamic Electron Polarization.
[So] Source:J Phys Chem Lett;9(3):672-676, 2018 Feb 01.
[Is] ISSN:1948-7185
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The possibility to probe the accessibility of sites of proteins represents an important point to explore their interactions with specific substrates in solution. The dynamic electron polarization of nitroxide radicals induced by excited triplet states of organic molecules is a phenomenon that is known to occur in aqueous solutions. The interaction within the radical-triplet pair causes a net emissive dynamic electron polarization of the nitroxide radical, that can be detected by means of time-resolved electron paramagnetic resonance (TR-EPR) spectroscopy. We have exploited this effect to prove the accessibility of chlorophylls bound to a protein, namely, the water-soluble chlorophyll protein WSCP. The results have important implications for topological studies in macromolecules.
[Mh] Termos MeSH primário: Clorofila/química
Óxidos de Nitrogênio/química
Proteínas/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância de Spin Eletrônica
Transporte de Elétrons
Radicais Livres
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radicals); 0 (Nitrogen Oxides); 0 (Proteins); 1406-65-1 (Chlorophyll); GFQ4MMS07W (nitroxyl)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jpclett.7b03428


  3 / 5672 MEDLINE  
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[PMID]:28745873
[Au] Autor:Nauser T; Gebicki JM
[Ad] Endereço:Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology , Zurich CH8093, Switzerland.
[Ti] Título:Physiological Concentrations of Ascorbate Cannot Prevent the Potentially Damaging Reactions of Protein Radicals in Humans.
[So] Source:Chem Res Toxicol;30(9):1702-1710, 2017 09 18.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The principal initial biological targets of free radicals formed under conditions of oxidative stress are the proteins. The most common products of the interaction are carbon-centered alkyl radicals which react rapidly with oxygen to form peroxyl radicals and hydroperoxides. All these species are reactive, capable of propagating the free radical damage to enzymes, nucleic acids, lipids, and endogenous antioxidants, leading finally to the pathologies associated with oxidative stress. The best chance of preventing this chain of damage is in early repair of the protein radicals by antioxidants. Estimate of the effectiveness of the physiologically significant antioxidants requires knowledge of the antioxidant tissue concentrations and rate constants of their reaction with protein radicals. Previous studies by pulse radiolysis have shown that only ascorbate can repair the Trp and Tyr protein radicals before they form peroxyl radicals under physiological concentrations of oxygen. We have now extended this work to other protein C-centered radicals generated by hydroxyl radicals because these and many other free radicals formed under oxidative stress can produce secondary radicals on virtually any amino acid residue. Pulse radiolysis identified two classes of rate constants for reactions of protein radicals with ascorbate, a faster one in the range (9-60) × 10 M s and a slow one with a range of (0.5-2) × 10 M s . These results show that ascorbate can prevent further reactions of protein radicals only in the few human tissues where its concentration exceeds about 2.5 mM.
[Mh] Termos MeSH primário: Ácido Ascórbico/química
Radicais Livres/química
Proteínas/química
[Mh] Termos MeSH secundário: Raios gama
Seres Humanos
Insulina/química
Muramidase/química
Óxidos de Nitrogênio/química
Radiólise de Impulso
Albumina Sérica/química
Espectrofotometria Ultravioleta
Triptofano/química
Tirosina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Free Radicals); 0 (Insulin); 0 (Nitrogen Oxides); 0 (Proteins); 0 (Serum Albumin); 42HK56048U (Tyrosine); 8DUH1N11BX (Tryptophan); EC 3.2.1.17 (Muramidase); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180127
[Lr] Data última revisão:
180127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.7b00160


  4 / 5672 MEDLINE  
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[PMID]:29244457
[Au] Autor:Urakova MA; Bryndina IG
[Ti] Título:Water balance of lung and nitrogen oxide in blood at experimental autoimmune encephalomyelitis after capsaicin blockade of vagus nerve.
[So] Source:Patol Fiziol Eksp Ter;60(3):18-22, 2016 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose of the research: To study the water balance of lung and NO level in blood in experimental autoimmune encephalomyelitis combined with capsaicin blockade of vagus nerve. Methods: Experiments were conducted on 47 adult (16-week-old) male rats weighing 220-280 g. To simulate the experimental autoimmune encephalomyelitis (EAE) rats were subcutaneously injected with encephalitogenic mixture in complete Freund's adjuvant (0.2 ml; the content of inactivated Mycobacterium tuberculosis was 5 mg/ml) at the rate of 100 mg of homologous spinal cord homogenate per animal. Сapsaicin blockade was performed by bilateral application of 50 uM capsaicin («Sigma¼) on the neck portions of vagus nerves. The animals were divided into 4 groups: intact rats - control group1; rats with EAE; rats with capsaicin application on vagus nerve + EAE; sham operated rats subjected to vagus nerves allocation without the subsequent capsaicin application + EAE - control group 2. The next parameters were detected: the content of nitric oxide in blood plasma; protein content in broncho-alveolar lavage fluid; lung water balance indices including the amount of total, extra- and intravascular fluid and blood supply of lungs, which were calculated based on wet and dry lung mass and the hemoglobin content in blood and lung tissue determined by hemiglobincyanide method. Results: It was found that EAE is accompanied by an increase of total fluid, extravascular fluid (EVF) and blood supply of lungs on the background of increasing content of nitric oxide in arterial (art) and venous (ven) blood. In EAE and its combination with bilateral capsaicin blockade of vagus nerve a strong negative correlation between the NOart / NOven coefficient and EVF amount was found out. The blockade of capsaicin-sensitive vagal afferents normalized lung water balance impaired in EAE and restored the levels of nitric oxide in blood plasma. Conclusion: The obtained results suggest that capsaicin-sensitive vagal afferents with NO-ergic mechanisms involvment take part in the development of pulmonary hyperhydration during experimental autoimmune encephalomyelitis.
[Mh] Termos MeSH primário: Capsaicina/efeitos adversos
Encefalomielite Autoimune Experimental
Pulmão
Óxidos de Nitrogênio
Nervo Vago
Equilíbrio Hidroeletrolítico
[Mh] Termos MeSH secundário: Animais
Capsaicina/farmacologia
Encefalomielite Autoimune Experimental/sangue
Encefalomielite Autoimune Experimental/imunologia
Pulmão/imunologia
Pulmão/metabolismo
Masculino
Óxidos de Nitrogênio/sangue
Óxidos de Nitrogênio/imunologia
Ratos
Equilíbrio Hidroeletrolítico/efeitos dos fármacos
Equilíbrio Hidroeletrolítico/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Oxides); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  5 / 5672 MEDLINE  
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[PMID]:29096811
[Au] Autor:Divakaran S; Loscalzo J
[Ad] Endereço:Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
[Ti] Título:The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics.
[So] Source:J Am Coll Cardiol;70(19):2393-2410, 2017 Nov 07.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of nitroglycerin in the treatment of angina pectoris began not long after its original synthesis in 1847. Since then, the discovery of nitric oxide as a biological effector and better understanding of its roles in vasodilation, cell permeability, platelet function, inflammation, and other vascular processes have advanced our knowledge of the hemodynamic (mostly mediated through vasodilation of capacitance and conductance arteries) and nonhemodynamic effects of organic nitrate therapy, via both nitric oxide-dependent and -independent mechanisms. Nitrates are rapidly absorbed from mucous membranes, the gastrointestinal tract, and the skin; thus, nitroglycerin is available in a number of preparations for delivery via several routes: oral tablets, sublingual tablets, buccal tablets, sublingual spray, transdermal ointment, and transdermal patch, as well as intravenous formulations. Organic nitrates are commonly used in the treatment of cardiovascular disease, but clinical data limit their use mostly to the treatment of angina. They are also used in the treatment of subsets of patients with heart failure and pulmonary hypertension. One major limitation of the use of nitrates is the development of tolerance. Although several agents have been studied for use in the prevention of nitrate tolerance, none are currently recommended owing to a paucity of supportive clinical data. Only 1 method of preventing nitrate tolerance remains widely accepted: the use of a dosing strategy that provides an interval of no or low nitrate exposure during each 24-h period. Nitric oxide's important role in several cardiovascular disease mechanisms continues to drive research toward finding novel ways to affect both endogenous and exogenous sources of this key molecular mediator.
[Mh] Termos MeSH primário: Fármacos Cardiovasculares/administração & dosagem
Doenças Cardiovasculares/tratamento farmacológico
Óxidos de Nitrogênio/administração & dosagem
Nitroglicerina/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Fármacos Cardiovasculares/metabolismo
Doenças Cardiovasculares/metabolismo
Doenças Cardiovasculares/patologia
Vias de Administração de Medicamentos
Seres Humanos
Óxidos de Nitrogênio/metabolismo
Nitroglicerina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cardiovascular Agents); 0 (Nitrogen Oxides); G59M7S0WS3 (Nitroglycerin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


  6 / 5672 MEDLINE  
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[PMID]:28991422
[Au] Autor:Ngo NS
[Ti] Título:Emission Standards, Public Transit, and Infant Health.
[So] Source:J Policy Anal Manage;36(4):773-89, 2017.
[Is] ISSN:0276-8739
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transit buses are an integral part of urban life. They reduce externalities generated from private vehicles and increase geographic mobility. However, unlike most private vehicles in the United States, they use diesel fuel and emit higher amounts of toxic pollutants. The U.S. Environmental Protection Agency set emission standards for transit buses starting in 1988 that have been continually updated, but their public health and economic impacts are unclear due to scarce emissions data. I construct a novel panel dataset for the New York City (NYC) Transit bus fleet between 1990 and 2009 and examine the impact of bus pollution on infant health by using bus vintage as a proxy for emissions. I exploit the variation in vintage as older buses are retired and replaced with newer, lower-emitting buses forced to adhere to stricter emission standards. I then assign maternal exposure to bus vintage at the census block level. Findings suggest that maternal exposure to the oldest, unregulated buses is associated with modest reductions in birth weight and gestational age relative to newer buses that abide by emissions policies. I then conduct a back-of-the-envelope cost-benefit calculation and find net economic benefits of $53.3 million resulting from improved emission standards for the 2009 birth cohort in NYC. Since the treatment in this study clearly maps to federal emissions policies, these results are the first to provide credible evidence that transit bus emission standards had a positive effect on infant health.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/efeitos adversos
Poluentes Atmosféricos/normas
Poluição do Ar/efeitos adversos
Saúde do Lactente/estatística & dados numéricos
Veículos Automotores/normas
Óxidos de Nitrogênio/efeitos adversos
Emissões de Veículos
[Mh] Termos MeSH secundário: Índice de Apgar
Peso ao Nascer
Idade Gestacional
Seres Humanos
Lactente
Saúde do Lactente/tendências
Cidade de Nova Iorque
Transportes/normas
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Nitrogen Oxides); 0 (Vehicle Emissions)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE


  7 / 5672 MEDLINE  
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[PMID]:28766121
[Au] Autor:Arenas Amado A; Schilling KE; Jones CS; Thomas N; Weber LJ
[Ad] Endereço:IIHR-Hydroscience & Engineering, The University of Iowa, 300 South Riverside Dr, Iowa City, IA, 52242-1585, USA. antonio-arenasamado@uiowa.edu.
[Ti] Título:Estimation of tile drainage contribution to streamflow and nutrient loads at the watershed scale based on continuously monitored data.
[So] Source:Environ Monit Assess;189(9):426, 2017 Sep.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nitrogen losses from artificially drained watersheds degrade water quality at local and regional scales. In this study, we used an end-member mixing analysis (EMMA) together with high temporal resolution water quality and streamflow data collected in the 122 km Otter Creek watershed located in northeast Iowa. We estimated the contribution of three end-members (groundwater, tile drainage, and quick flow) to streamflow and nitrogen loads and tested several combinations of possible nitrate concentrations for the end-members. Results indicated that subsurface tile drainage is responsible for at least 50% of the watershed nitrogen load between April 15 and November 1, 2015. Tiles delivered up to 80% of the stream N load while providing only 15-43% of the streamflow, whereas quick flows only marginally contributed to N loading. Data collected offer guidance about areas of the watershed that should be targeted for nitrogen export mitigation strategies.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Fósforo/análise
Rios/química
Movimentos da Água
Poluentes da Água/análise
[Mh] Termos MeSH secundário: Iowa
Nitratos/análise
Nitrogênio/análise
Óxidos de Nitrogênio/análise
Qualidade da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrogen Oxides); 0 (Water Pollutants); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6139-4


  8 / 5672 MEDLINE  
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[PMID]:28709125
[Au] Autor:Verderosa AD; de la Fuente-Núñez C; Mansour SC; Cao J; Lu TK; Hancock REW; Fairfull-Smith KE
[Ad] Endereço:ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Faculty of Science and Engineering, Queensland University of Technology, Queensland 4001, Australia.
[Ti] Título:Ciprofloxacin-nitroxide hybrids with potential for biofilm control.
[So] Source:Eur J Med Chem;138:590-601, 2017 Sep 29.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:As bacterial biofilms display extreme tolerance to conventional antibiotic treatments, it has become imperative to develop new antibacterial strategies with alternative mechanisms of action. Herein, we report the synthesis of a series of ciprofloxacin-nitroxide conjugates and their corresponding methoxyamine derivatives in high yield. This was achieved by linking various nitroxides or methoxyamines to the secondary amine of the piperazine ring of ciprofloxacin using amide bond coupling. Biological evaluation of the prepared compounds on preformed P. aeruginosa biofilms in flow cells revealed substantial dispersal with ciprofloxacin-nitroxide hybrid 25, and virtually complete killing and removal (94%) of established biofilms in the presence of ciprofloxacin-nitroxide hybrid 27. Compounds 25-28 were shown to be non-toxic in both human embryonic kidney 293 (HEK 293) cells and human muscle rhabdomyosarcoma (RD) cells at concentrations up to 40 µM. Significantly, these hybrids demonstrate the potential of antimicrobial-nitroxide agents to overcome the resistance of biofilms to antimicrobials via stimulation of biofilm dispersal or through direct cell killing.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Biofilmes/efeitos dos fármacos
Ciprofloxacino/farmacologia
Óxidos de Nitrogênio/farmacologia
Pseudomonas aeruginosa/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Linhagem Celular Tumoral
Ciprofloxacino/química
Relação Dose-Resposta a Droga
Células HEK293
Seres Humanos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Óxidos de Nitrogênio/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Nitrogen Oxides); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


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[PMID]:28707660
[Au] Autor:Abramova TO; Ryazanova MA; Antonov EV; Redina OE; Markel AL
[Ad] Endereço:Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
[Ti] Título:[Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension].
[So] Source:Mol Biol (Mosk);51(3):442-446, 2017 May-Jun.
[Is] ISSN:0026-8984
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.
[Mh] Termos MeSH primário: Epóxido Hidrolases/biossíntese
Estresse Oxidativo/genética
Estresse Fisiológico/genética
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea
Modelos Animais de Doenças
Epóxido Hidrolases/isolamento & purificação
Seres Humanos
Hipertensão/enzimologia
Hipertensão/patologia
Medula Renal/enzimologia
Medula Renal/patologia
Masculino
Óxido Nítrico Sintase/genética
Óxidos de Nitrogênio/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Oxides); EC 1.14.13.39 (Nitric Oxide Synthase); EC 3.3.2.- (Epoxide Hydrolases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.7868/S0026898417020021


  10 / 5672 MEDLINE  
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[PMID]:28677264
[Au] Autor:Wu QJ; Wang YQ; Qi YX
[Ad] Endereço:College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
[Ti] Título:Influence of procyanidin supplementation on the immune responses of broilers challenged with lipopolysaccharide.
[So] Source:Anim Sci J;88(7):983-990, 2017 Jul.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:In the present study, the effect of dietary procyanidin (PCA, from pine needles) supplementation on the innate immunity of broilers were investigated. The experiment was designed as a 2 × 4 factorial arrangement (eight cages / treatment; six birds (one-day-old) / cage) with dietary PCA concentrations (0, 0.05, 0.075 and 0.1%) and two immune treatments (injection of lipopolysaccharide (LPS) (0.5 mg/kg body weight) or saline). LPS was dissolved in sterile 9 g/L (w/v) NaCl solution at 16, 18, 20 days of age to mimic immune stress. The remaining birds were injected with saline as a placebo. The results indicated that, prior to LPS challenge, the PCA diet had no significant effect on bird growth performance. The injection of LPS was also not associated with any significant changes in poultry performance. LPS injection increased the activity of nitrogen oxides (NOx) and the concentrations of inflammatory cytokines (interferon-γ (IFN-γ), interleukin-1ß (IL-1ß), IL-2, IL-4, IL-6 and IL-10) in serum; dietary PCA decreased these concentrations (P < 0.05) in the PCA 0.1% group, further illustrating the immune effect of PCA. In conclusion, PCA supplementation has a beneficial effect on LPS challenge, which may be associated with the inhibition of the secretion of cytokines and decrease in the proinflammatory marker NOx.
[Mh] Termos MeSH primário: Ração Animal
Biflavonoides/farmacologia
Catequina/farmacologia
Galinhas/imunologia
Dieta/veterinária
Suplementos Nutricionais
Imunidade Inata/efeitos dos fármacos
Lipopolissacarídeos/imunologia
Proantocianidinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Biflavonoides/administração & dosagem
Catequina/administração & dosagem
Citocinas/sangue
Mediadores da Inflamação/sangue
Mediadores da Inflamação/metabolismo
Óxidos de Nitrogênio/metabolismo
Pinus/química
Proantocianidinas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Nitrogen Oxides); 0 (Proanthocyanidins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12729



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