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[PMID]: 28538156 [Au] Autor: Ma H; Xu J; Jin J; Huang Y; Liu Y [Ad] Endereço: Biomedical and Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania. [Ti] Título: A Simple Marker-Assisted 3D Nanometer Drift Correction Method for Superresolution Microscopy. [So] Source: Biophys J;112(10):2196-2208, 2017 May 23. [Is] ISSN: 1542-0086 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: High-precision fluorescence microscopy such as superresolution imaging or single-particle tracking often requires an online drift correction method to maintain the stability of the three-dimensional (3D) position of the sample at a nanometer precision throughout the entire data acquisition process. Current online drift correction methods require modification of the existing two-dimensional (2D) fluorescence microscope with additional optics and detectors, which can be cumbersome and limit its use in many biological laboratories. Here we report a simple marker-assisted online drift correction method in which all 3D positions can be derived from fiducial markers on the coverslip of the sample on a standard 2D fluorescence microscope without additional optical components. We validate this method by tracking the long-term 3D stability of single-molecule localization microscopy at a precision of <2 and 5 nm in the lateral and axial dimension, respectively. We then provide three examples to evaluate the performance of the marker-assisted drift correction method. Finally, we give an example of a biological application of superresolution imaging of spatiotemporal alteration for a DNA replication structure with both low-abundance newly synthesized DNAs at the early onset of DNA synthesis and gradually condensed DNA structures during DNA replication. Using an isogenic breast cancer progression cell line model that recapitulates normal-like, precancerous, and tumorigenic stages, we characterize a distinction in the DNA replication process in normal, precancerous, and tumorigenic cells. [Mh] Termos MeSH primário: Imagem Tridimensional/métodos Microscopia de Fluorescência/métodos [Mh] Termos MeSH secundário: Linhagem Celular Tumoral Análise por Conglomerados Replicação do DNA Marcadores Fiduciais Compostos de Ouro Seres Humanos Imagem Tridimensional/instrumentação Nanopartículas Metálicas Microscopia de Fluorescência/instrumentação Microtúbulos/metabolismo Imagem Molecular/instrumentação Imagem Molecular/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES [Nm] Nome de substância: 0 (Gold Compounds) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170809 [Lr] Data última revisão: 170809 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170525 [St] Status: MEDLINE

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[PMID]: 28377235 [Au] Autor: Rajkumari J; Busi S; Vasu AC; Reddy P [Ad] Endereço: Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry 605014, India. [Ti] Título: Facile green synthesis of baicalein fabricated gold nanoparticles and their antibiofilm activity against Pseudomonas aeruginosa PAO1. [So] Source: Microb Pathog;107:261-269, 2017 Jun. [Is] ISSN: 1096-1208 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Biofilm formation is one of the major problems associated with chronic diseases and also attributes for the antibiotic resistance in bacteria. In recent times nanoparticles have been utilized to improve the efficacy of the existing antimicrobial and anti-biofilm agents. The ease in functionalization of gold nanoparticles (AuNPs) makes them a potential carrier for antimicrobial agents. However, the use of physical or chemical methods of the production of nanoparticles is expensive, labour intensive and hazardous to ecosystem. On the other hand, the use of plant based compounds serve as an eco-friendly way for the synthesis of nanoparticles with improved biocompatibility and therapeutic applicability. In the present study, phytocompound, baicalein was used as a reducing and capping agent for the synthesis of spherical shape AuNPs. The baicalein decorated gold nanoparticles (BCL-AuNPs) were characterized and evaluated for their anti-biofilm efficacy against Pseudomonas aeruginosa PAO1. The biosynthesized BCL-AuNPs was characterized using UV-Visible spectra, Dynamic Light Scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Diffraction (EDAX), and High Resolution Transmission Electron Microscopy (HR-TEM). The biosynthesized BCL-AuNPs were determined to be spherical in shape with an average size of 26.5 nm. The sub-MIC concentration of BCL-AuNPs exhibited significant anti-biofilm activity against P. aeruginosa PAO1. On treatment with BCL-AuNPs (100 g mL ), a reduction in biofilm formation by 58.74 ± 5.8% and 76.51 ± 4.27% was observed in microtiter plate assay and tube method, respectively. A significant reduction in exopolysaccharide (EPS) production by 81.29± 2.96% was observed. The swimming and swarming motility were also effectively arrested in presence of BCL-AuNPs. Further, Light microscope and CLSM studies were carried out to examine the effect of BCL-AuNPs on the surface topography and architecture of P. aeruginosa biofilm. Thus, the present study suggests the potential use of BCL-AuNPs in the development of novel therapeutics for the prevention and treatment of biofilm associated chronic infections. [Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos Flavanonas/química Flavanonas/farmacologia Compostos de Ouro/química Nanopartículas Metálicas/química Pseudomonas aeruginosa/efeitos dos fármacos [Mh] Termos MeSH secundário: Antibacterianos/química Antibacterianos/farmacologia Materiais Biocompatíveis Biofilmes/crescimento & desenvolvimento Cloretos Portadores de Fármacos/química Química Verde Nanopartículas Metálicas/ultraestrutura Testes de Sensibilidade Microbiana Microscopia Eletrônica de Varredura Microscopia Eletrônica de Transmissão Extratos Vegetais/química Polissacarídeos Bacterianos/análise Pseudomonas aeruginosa/crescimento & desenvolvimento Pseudomonas aeruginosa/patogenicidade Espectrofotometria Ultravioleta Espectroscopia de Infravermelho com Transformada de Fourier Difração de Raios X [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Biocompatible Materials); 0 (Chlorides); 0 (Drug Carriers); 0 (Flavanones); 0 (Gold Compounds); 0 (Plant Extracts); 0 (Polysaccharides, Bacterial); 128531-82-8 (exopolysaccharide, Pseudomonas); 49QAH60606 (baicalein); 8H372EGX3V (gold tetrachloride, acid) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171027 [Lr] Data última revisão: 171027 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170406 [St] Status: MEDLINE

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[PMID]: 27912141 [Au] Autor: Palanivel A; Chennaiah A; Dubbu S; Mallick A; Vankar YD [Ad] Endereço: Department of Chemistry, Indian Institute of Technology Kanpur 208 016, India. [Ti] Título: AuCl -AgOTf promoted O-glycosylation using anomeric sulfoxides as glycosyl donors at room temperature. [So] Source: Carbohydr Res;437:43-49, 2017 Jan 02. [Is] ISSN: 1873-426X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Activation of sulfoxide as glycosyl donors using AuCl /AgOTf reagent system has been described. Under optimal reaction conditions, both armed and disarmed glycosyl sulfoxide donors were found to react with a range of primary, secondary, and tertiary alcohol acceptors, and sugar derived glycosyl acceptors to afford the corresponding glycosides in moderate to good yields with predictable selectivity. The reactions are quick (20-60 min), facile at room temperature and the reactions conditions tolerate acid sensitive groups. [Mh] Termos MeSH primário: Bioquímica de Carboidratos/métodos Glicosídeos/síntese química Compostos de Ouro/química Mesilatos/química Sulfóxidos/química [Mh] Termos MeSH secundário: Catálise Glicosídeos/química Glicosilação Temperatura Ambiente [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Glycosides); 0 (Gold Compounds); 0 (Mesylates); 0 (Sulfoxides); 11118-27-7 (gold chloride); JE2SY203E8 (trifluoromethanesulfonic acid) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170130 [Lr] Data última revisão: 170130 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161203 [St] Status: MEDLINE

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[PMID]: 27896311 [Au] Autor: Nakano T; Mackay SM; Wui Tan E; Dani KM; Wickens J [Ad] Endereço: Neurobiology Research Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son 904-0412, Okinawa, Japan; Department of Neurobiology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan. [Ti] Título: Interfacing with Neural Activity via Femtosecond Laser Stimulation of Drug-Encapsulating Liposomal Nanostructures. [So] Source: eNeuro;3(6), 2016 Nov-Dec. [Is] ISSN: 2373-2822 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: External control over rapid and precise release of chemicals in the brain potentially provides a powerful interface with neural activity. Optical manipulation techniques, such as optogenetics and caged compounds, enable remote control of neural activity and behavior with fine spatiotemporal resolution. However, these methods are limited to chemicals that are naturally present in the brain or chemically suitable for caging. Here, we demonstrate the ability to interface with neural functioning via a wide range of neurochemicals released by stimulating loaded liposomal nanostructures with femtosecond lasers. Using a commercial two-photon microscope, we released inhibitory or excitatory neurochemicals to evoke subthreshold and suprathreshold changes in membrane potential in a live mouse brain slice. The responses were repeatable and could be controlled by adjusting laser stimulation characteristics. We also demonstrate the release of a wider range of chemicals-which previously were impossible to release by optogenetics or uncaging-including synthetic analogs of naturally occurring neurochemicals. In particular, we demonstrate the release of a synthetic receptor-specific agonist that exerts physiological effects on long-term synaptic plasticity. Further, we show that the loaded liposomal nanostructures remain functional for weeks in a live mouse. In conclusion, we demonstrate new techniques capable of interfacing with live neurons, and extendable to applications. [Mh] Termos MeSH primário: Lasers Lipossomos Nanoestruturas Neurônios/efeitos dos fármacos Neurotransmissores/administração & dosagem [Mh] Termos MeSH secundário: 2,3,4,5-Tetra-Hidro-7,8-Di-Hidroxi-1-Fenil-1H-3-Benzazepina/administração & dosagem Animais Corpo Estriado/efeitos dos fármacos Corpo Estriado/fisiologia Sistemas de Liberação de Medicamentos Compostos de Ouro Proteínas de Fluorescência Verde/genética Proteínas de Fluorescência Verde/metabolismo Hipocampo/efeitos dos fármacos Hipocampo/fisiologia Masculino Potenciais da Membrana/efeitos dos fármacos Camundongos Endogâmicos C57BL Camundongos Transgênicos Microscopia Muscimol/administração & dosagem Plasticidade Neuronal/efeitos dos fármacos Plasticidade Neuronal/fisiologia Neurônios/fisiologia Técnicas de Patch-Clamp Receptores de Dopamina D1/agonistas Receptores de Dopamina D1/genética Receptores de Dopamina D1/metabolismo Técnicas de Cultura de Tecidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drd1a protein, mouse); 0 (Gold Compounds); 0 (Liposomes); 0 (Neurotransmitter Agents); 0 (Receptors, Dopamine D1); 0 (enhanced green fluorescent protein); 147336-22-9 (Green Fluorescent Proteins); 2763-96-4 (Muscimol); 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171025 [Lr] Data última revisão: 171025 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161130 [St] Status: MEDLINE

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[PMID]: 27427704 [Au] Autor: Yoo J; Park SJ; Lee SW [Ti] Título: Facile Synthesis of Silica-Encapsulated Gold Nanoflowers as Surface-Enhanced Raman Scattering Probes Using Silane-Mediated Sol-Gel Reaction. [So] Source: J Nanosci Nanotechnol;16(6):6289-93, 2016 Jun. [Is] ISSN: 1533-4880 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Flower-like gold nanoparticles, so called gold nanoflowers (AuNFs), were synthesized through the reduction of HAuC4 with ascorbic acid in the presence of chitosan polymers. Chitosan-mediated AuNFs exhibited the distinct SERS signals of 2-chlorothiophenol (CTP) due to the presence of many interstitial gaps (so called hot spots) on the surface. For the facile silica coating, the AuNFs were conjugated with terminal carboxylate groups of (3-glycidyloxypropyl)trimethoxysilane (GPTMS), consequently forming alkoxy-terminated AuNFs which could facilely participate in the sol-gel reaction for silica coating. The resulting core-shell particles, i.e., CTP-adsorbed AuNFs with silica coating, exhibited the distinct SERS signals of CTP embedded within silica layer, warranting the effectiveness of this chemical strategy for spectroscopic labeling of Raman probes. [Mh] Termos MeSH primário: Ouro/química Nanopartículas Metálicas/química Nanotecnologia Silanos/química Dióxido de Silício/química Análise Espectral Raman/métodos [Mh] Termos MeSH secundário: Cápsulas Cloretos/química Géis Compostos de Ouro/química Modelos Moleculares Conformação Molecular Oxirredução [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Capsules); 0 (Chlorides); 0 (Gels); 0 (Gold Compounds); 0 (Silanes); 7440-57-5 (Gold); 7631-86-9 (Silicon Dioxide); 8H372EGX3V (gold tetrachloride, acid) [Em] Mês de entrada: 1609 [Cu] Atualização por classe: 160718 [Lr] Data última revisão: 160718 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160719 [St] Status: MEDLINE

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[PMID]: 27417730 [Au] Autor: Sokolov OI; Selivanov NY; Bogatyrev VA; Selivanova OG; Velikorodnaya YI; Pocheptsov AY; Filatov BN; Shchyogolev SY; Dykman LA [Ad] Endereço: Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, pr. Entuziastov 13, Saratov, 410015, Russia. sokolov@ibppm.sgu.ru. [Ti] Título: Synthesis and study on activity in vitro of the high purity human butyrylcholinesterase conjugated with gold nanoparticles. [So] Source: Dokl Biochem Biophys;468(1):232-4, 2016 May. [Is] ISSN: 1608-3091 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: The aim of this research was to design a method of immobilization of high-purity human butyrylcholinesterase on the surface of gold nanoparticles preserving the activity of the enzyme. In order to achieve this aim, the method of fractionation and purification of human butyrylcholinesterase from plasma was modified. The synthesis of 15-nm gold nanoparticles was carried out by citrated method. A method of conjugation of the high-purity butyrylcholinesterase with gold nanoparticles was developed. It was found that the Immobilization of butyrylcholinesterase on the surface of gold nanoparticles resulted in a significant (to 23%) increase in the specific activity of the enzyme. [Mh] Termos MeSH primário: Butirilcolinesterase Compostos de Ouro/síntese química Nanopartículas Metálicas [Mh] Termos MeSH secundário: Butirilcolinesterase/química Butirilcolinesterase/isolamento & purificação Estabilidade Enzimática Compostos de Ouro/química Seres Humanos Concentração de Íons de Hidrogênio Nanopartículas Metálicas/química Tamanho da Partícula [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Gold Compounds); EC 3.1.1.8 (Butyrylcholinesterase) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160716 [St] Status: MEDLINE [do] DOI: 10.1134/S1607672916030212

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[PMID]: 27283636 [Au] Autor: Qin J; Xie L; Ying Y [Ad] Endereço: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, PR China. [Ti] Título: A high-sensitivity terahertz spectroscopy technology for tetracycline hydrochloride detection using metamaterials. [So] Source: Food Chem;211:300-5, 2016 Nov 15. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Antibiotic residues in animal-derived food due to their overuse in veterinary medicine will have potential adverse effects on human health. The rapid and accurate detection of these drugs is essential for ensuring human food safety. In particular, the current detection methods are usually limited by the low sensitivity or the tedious pre-treatment. Here we demonstrate that metamaterials operating at terahertz frequencies, acting as highly sensitive sensors, show promising potential for the detection of tetracycline hydrochloride (TCH). We were able to detect a trace amount of TCH, as small as 0.1mg/L, which was about 10(5) times enhancement compared to the measurement of TCH on a silicon substance. Our study is likely to constitute an important step toward the detection of antibiotic residues in a food matrix. [Mh] Termos MeSH primário: Antibacterianos/análise Inocuidade dos Alimentos/métodos Compostos de Ouro/química Espectroscopia Terahertz/métodos Tetraciclina/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Gold Compounds); F8VB5M810T (Tetracycline) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170119 [Lr] Data última revisão: 170119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160611 [St] Status: MEDLINE

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[PMID]: 27276256 [Au] Autor: Roh SH; Kasembeli MM; Galaz-Montoya JG; Chiu W; Tweardy DJ [Ad] Endereço: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas. [Ti] Título: Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. [So] Source: Biophys J;110(11):2377-2385, 2016 Jun 07. [Is] ISSN: 1542-0086 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: AML1-ETO is the translational product of a chimeric gene created by the stable chromosome translocation t (8;21)(q22;q22). It causes acute myeloid leukemia (AML) by dysregulating the expression of genes critical for myeloid cell development and differentiation and recently has been reported to bind multiple subunits of the mammalian cytosolic chaperonin TRiC (or CCT), primarily through its DNA binding domain (AML1-175). Through these interactions, TRiC plays an important role in the synthesis, folding, and activity of AML1-ETO. Using single-particle cryo-electron microscopy, we demonstrate here that a folding intermediate of AML1-ETO's DNA-binding domain (AML1-175) forms a stable complex with apo-TRiC. Our structure reveals that AML1-175 associates directly with a specific subset of TRiC subunits in the open conformation. [Mh] Termos MeSH primário: Chaperonina com TCP-1/metabolismo Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo Proteínas de Fusão Oncogênicas/metabolismo [Mh] Termos MeSH secundário: Western Blotting Cromatografia em Gel Microscopia Crioeletrônica DNA/metabolismo Compostos de Ouro Proteínas de Choque Térmico HSP70/metabolismo Células HeLa Seres Humanos Imagem Tridimensional Espectrometria de Massas Nanopartículas Metálicas Domínios Proteicos Dobramento de Proteína Multimerização Proteica Estabilidade Proteica Proteína 1 Parceira de Translocação de RUNX1 [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (AML1-ETO fusion protein, human); 0 (Core Binding Factor Alpha 2 Subunit); 0 (Gold Compounds); 0 (HSP70 Heat-Shock Proteins); 0 (Oncogene Proteins, Fusion); 0 (RUNX1 Translocation Partner 1 Protein); 9007-49-2 (DNA); EC 3.6.1.- (Chaperonin Containing TCP-1) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160609 [St] Status: MEDLINE

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[PMID]: 27166528 [Au] Autor: Selim ME; Hendi AA; Alfallaj E [Ad] Endereço: Zoology Department, Faculty of Science, King Saud University, Ain Shams University, Cairo, Egypt. [Ti] Título: The possible counteractive effect of gold nanoparticles against streptozotocin-induced type 1 diabetes in young male albino rats. [So] Source: Pak J Pharm Sci;29(3):823-36, 2016 May. [Is] ISSN: 1011-601X [Cp] País de publicação: Pakistan [La] Idioma: eng [Ab] Resumo: The current study was performed to study the effect of biologically synthesised gold nanoparticles (AuNPs) to control hyperglycaemic conditions in streptozotocin (STZ)-induced diabetic mice. In this study, the rats were divided into four groups: Group I normal control rats (non-diabetic, untreated); Group II diabetes-induced rats used as diabetic controls DC (diabetic, untreated). Group III diabetes-induced rats treated with AuNPs DT; Group IV normal rats treated with AuNPs NT. Diabetes was induced by administering an intraperitoneal injection of a freshly prepared solution of STZ (50mg/kg body weight (bw)). The glucose level was significantly increased in the diabetic control rats compared with the controls (P<0.001). Decreased liver function and kidney function were detected in the diabetic treated rats and normal treated rats after AuNP administration compared with the controls. The present study is the first to demonstrate that AuNPs significantly enhance antioxidant production in STZ-induced diabetic rats, a recognised model of type 1 diabetes mellitus (T1DM). [Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos Diabetes Mellitus Experimental/tratamento farmacológico Diabetes Mellitus Tipo 1/tratamento farmacológico Compostos de Ouro/farmacologia Hipoglicemiantes/farmacologia Nanopartículas Metálicas Estreptozocina [Mh] Termos MeSH secundário: Fatores Etários Animais Antioxidantes/metabolismo Biomarcadores/sangue Glicemia/metabolismo Nitrogênio da Ureia Sanguínea Creatinina/sangue Diabetes Mellitus Experimental/sangue Diabetes Mellitus Experimental/induzido quimicamente Diabetes Mellitus Tipo 1/sangue Diabetes Mellitus Tipo 1/induzido quimicamente Enzimas/sangue Teste de Tolerância a Glucose Masculino Ratos Fatores de Tempo Ácido Úrico/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antioxidants); 0 (Biomarkers); 0 (Blood Glucose); 0 (Enzymes); 0 (Gold Compounds); 0 (Hypoglycemic Agents); 268B43MJ25 (Uric Acid); 5W494URQ81 (Streptozocin); AYI8EX34EU (Creatinine) [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 160512 [Lr] Data última revisão: 160512 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160512 [St] Status: MEDLINE

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[PMID]: 27108675 [Au] Autor: Kim J; Kim DH; Lee SJ; Rheem Y; Myung NV; Hur HG [Ad] Endereço: a Division of System and Material Industry , Korea Evaluation Institute of Industrial Technology , Daegu , Republic of Korea. [Ti] Título: Synthesis of gold structures by gold-binding peptide governed by concentration of gold ion and peptide. [So] Source: Biosci Biotechnol Biochem;80(8):1478-83, 2016 Aug. [Is] ISSN: 1347-6947 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Although biological synthesis methods for the production of gold structures by microorganisms, plant extracts, proteins, and peptide have recently been introduced, there have been few reports pertaining to controlling their size and morphology. The gold ion and peptide concentrations affected on the size and uniformity of gold plates by a gold-binding peptide Midas-11. The higher concentration of gold ions produced a larger size of gold structures reached 125.5 µm, but an increased amount of Midas-11 produced a smaller size of gold platelets and increased the yield percentage of polygonal gold particles rather than platelets. The mechanisms governing factors controlling the production of gold structures were primarily related to nucleation and growth. These results indicate that the synthesis of gold architectures can be controlled by newly isolated and substituted peptides under different reaction conditions. [Mh] Termos MeSH primário: Materiais Biomiméticos/química Cloretos/química Compostos de Ouro/química Ouro/química Peptídeos/química [Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio Íons Microscopia Eletrônica de Varredura Tamanho da Partícula Ligação Proteica [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chlorides); 0 (Gold Compounds); 0 (Ions); 0 (Peptides); 7440-57-5 (Gold); 8H372EGX3V (gold tetrachloride, acid) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170118 [Lr] Data última revisão: 170118 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160426 [St] Status: MEDLINE [do] DOI: 10.1080/09168451.2016.1176516

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