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  1 / 2596 MEDLINE  
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[PMID]:28453699
[Au] Autor:Zhang L; Ye Y; Tu H; Hildebrandt MA; Zhao L; Heymach JV; Roth JA; Wu X
[Ad] Endereço:Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, USA.
[Ti] Título:MicroRNA-related genetic variants in iron regulatory genes, dietary iron intake, microRNAs and lung cancer risk.
[So] Source:Ann Oncol;28(5):1124-1129, 2017 05 01.
[Is] ISSN:1569-8041
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: Genetic variations in MicroRNA (miRNA) binding sites may alter structural accessibility of miRNA binding sites to modulate risk of cancer. This large-scale integrative multistage study was aimed to evaluate the interplay of genetic variations in miRNA binding sites of iron regulatory pathway, dietary iron intake and lung cancer (LC) risk. Patients and methods: The interplay of genetic variant, dietary iron intake and LC risk was assessed in large-scale case-control study. Functional characterization of the validated SNP and analysis of target miRNAs were performed. Results: We found that the miRNA binding site SNP rs1062980 in 3' UTR of Iron-Responsive Element Binding protein 2 gene (IREB2) was associated with a 14% reduced LC risk (P value = 4.9×10 - 9). Comparing to AA genotype, GG genotype was associated with a 27% reduced LC risk. This association was evident in males and ever-smokers but not in females and never-smokers. Higher level of dietary iron intake was significantly associated with 39% reduced LC risk (P value = 2.0×10 - 8). This association was only present in individuals with AG + AA genotypes with a 46% reduced risk (P value = 1.0×10 - 10), but not in GG genotype. The eQTL-analysis showed that rs1062980 significantly alters IREB2 expression level. Rs1062980 is predicted to alter a miR-29 binding site on IREB2 and indeed the expression of miR-29 is inversely correlated with IREB2 expression. Further, we found that higher circulating miR-29a level was significantly associated with 78% increased LC risk. Conclusion: The miRNA binding site SNP rs1062980 in iron regulatory pathway, which may alter the expression of IREB2 potentially through modulating the binding of miR-29a, together with dietary iron intake may modify risk of LC both individually and jointly. These discoveries reveal novel pathway for understanding lung cancer tumorigenesis and risk stratification.
[Mh] Termos MeSH primário: Ferro na Dieta/metabolismo
Neoplasias Pulmonares/genética
MicroRNAs/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Estudos de Associação Genética
Loci Gênicos
Predisposição Genética para Doença
Seres Humanos
Neoplasias Pulmonares/metabolismo
Redes e Vias Metabólicas/genética
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iron, Dietary); 0 (MicroRNAs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/annonc/mdx046


  2 / 2596 MEDLINE  
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[PMID]:28468891
[Au] Autor:Monnard A; Moretti D; Zeder C; Steingötter A; Zimmermann MB
[Ad] Endereço:Department of Health Sciences and Technology, Laboratory of Human Nutrition, ETH Zürich, Zurich, Switzerland; and.
[Ti] Título:The effect of lipids, a lipid-rich ready-to-use therapeutic food, or a phytase on iron absorption from maize-based meals fortified with micronutrient powders.
[So] Source:Am J Clin Nutr;105(6):1521-1527, 2017 Jun.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ready-to-use-therapeutic foods (RUTFs) high in lipid, protein, and iron are used to treat malnutrition. Lipids increase gastric residence time, which could increase iron absorption, particularly from poorly soluble iron compounds and in combination with phytase. The objectives were to ) assess the effect on iron absorption of a lipid emulsion given 20 min before or together with an iron-fortified maize meal and ) assess iron absorption from a micronutrient powder (MNP) given with a nutrient-dense RUTF and/or a microbial phytase. A total of 41 women participated in 3 studies. They consumed a maize meal fortified with isotopically labeled ferrous sulfate (FeSO ; study 1) or ferric pyrophosphate (FePP; study 2). In studies 1 and 2, a lipid emulsion was given with or 20 min before the meal. In study 3, with the use of a 2 × 2 factorial design, subjects consumed a maize meal fortified with an MNP containing labeled FeSO (MNP) given with an RUTF (MNP+RUTF), with a phytase (MNP+phytase), or both (MNP+RUTF+phytase). Iron absorption was assessed by isotope incorporation in erythrocytes 14 d after the test meals. The lipid emulsion given either before or with the meal significantly increased iron absorption from FePP by 2.55-fold (95% CI: 1.48-, 4.37-fold; = 0.001) but not from FeSO There was a trend to increase iron absorption with the MNP+RUTF meal, which did not reach significance (1.21-fold; 95% CI: 0.92-, 1.61-fold; = 0.060). The addition of phytase to MNP and MNP+RUTF significantly increased iron absorption by 1.85-fold (95% CI: 1.49-, 2.29-fold; < 0.001), with no interaction between phytase and RUTF. In iron-fortified maize-based meals, the addition of lipids more than doubles iron absorption from FePP. Our results suggest the possibility of an enhancing effect on iron absorption of lipid-rich RUTFs, but more research is needed to determine this. This trial was registered at clinicaltrials.gov as NCT01991626.
[Mh] Termos MeSH primário: 6-Fitase/farmacologia
Alimentos Fortificados
Absorção Intestinal/efeitos dos fármacos
Ferro na Dieta/sangue
Ferro/sangue
Lipídeos/farmacologia
Micronutrientes/sangue
[Mh] Termos MeSH secundário: Adulto
Suplementos Nutricionais
Difosfatos/sangue
Eritrócitos/metabolismo
Feminino
Ferritinas/sangue
Seres Humanos
Refeições
Pós
Adulto Jovem
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diphosphates); 0 (Iron, Dietary); 0 (Lipids); 0 (Micronutrients); 0 (Powders); 9007-73-2 (Ferritins); E1UOL152H7 (Iron); EC 3.1.3.26 (6-Phytase); QK8899250F (ferric pyrophosphate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142976


  3 / 2596 MEDLINE  
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[PMID]:29185934
[Au] Autor:Mohammed SH; Esmaillzadeh A
[Ad] Endereço:1Department of Community Nutrition,School of Nutritional Sciences and Dietetics,Tehran University of Medical Sciences-International Campus (TUMS-IC),PO Box 14155-6117, Tehran,Iran.
[Ti] Título:The relationships among iron supplement use, Hb concentration and linear growth in young children: Ethiopian Demographic and Health Survey.
[So] Source:Br J Nutr;118(9):730-736, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Growth faltering and anaemia remain unacceptably high among infants and young children in Ethiopia. In this study, we investigated the relationships among Fe supplement use (ISU), Hb concentration and linear growth, hypothesising positive relationships between ISU and Hb, ISU and linear growth and Hb and linear growth. We used a nationally representative data of 2400 children aged 6-24 months from the Ethiopian Demographic and Health Survey (EDHS) 2011, conducted following a stratified, two-stage cluster sampling. We examined the links by Pearson's correlation, bivariate and multivariate linear regression analyses and reported adjusted estimates. We found that ISU was not significantly associated with either Hb (ß=1·09; 95 % CI -2·73, 5·01, P=0·567) or linear growth (ß=0·07; 95 % CI -0·06, 0·21, P=0·217). We found a positive, however, weak, correlation between Hb and linear growth (r 0·09; 95 % CI 0·06, 0·11, P<0·001). Hb predicted linear growth independent of a variety dietary and non-dietary factors (ß=0·08; 95 % CI 0·04, 0·11, P<0·001). Although not the primary focus of the study, our analysis showed that age and breast-feeding duration were independently associated with Hb; age, birth type, size at birth, sex, breast-feeding duration, dietary diversity and deworming were independently associated with linear growth, indicating that Hb and linear growth are multifactorial with both nutritional and non-nutritional factors implicated. Further studies, with better design and exposure assessment, are warranted on the relation of ISU with Hb or linear growth.
[Mh] Termos MeSH primário: Anemia Ferropriva/epidemiologia
Desenvolvimento Infantil
Suplementos Nutricionais
Hemoglobinas/metabolismo
Fenômenos Fisiológicos da Nutrição do Lactente
Ferro na Dieta/administração & dosagem
[Mh] Termos MeSH secundário: Anemia Ferropriva/tratamento farmacológico
Aleitamento Materno
Pré-Escolar
Análise por Conglomerados
Estudos Transversais
Dieta
Etiópia/epidemiologia
Inquéritos Epidemiológicos
Seres Humanos
Lactente
Estado Nutricional
Prevalência
Tamanho da Amostra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Iron, Dietary)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002677


  4 / 2596 MEDLINE  
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[PMID]:28946930
[Au] Autor:Liao X; Ma C; Lu L; Zhang L; Luo X
[Ad] Endereço:State Key Laboratory of Animal Nutrition,Mineral Nutrition Research Division,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,People's Republic of China.
[Ti] Título:Determination of dietary iron requirements by full expression of iron-containing cytochrome c oxidase in the heart of broilers from 22 to 42 d of age.
[So] Source:Br J Nutr;118(7):493-499, 2017 Oct.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study was carried out to determine dietary Fe requirements for the full expression of Fe-containing enzyme in broilers chicks from 22 to 42 d of age. At 22 d of age, 288 Arbor Acres male chicks were randomly assigned to one of six treatments with six replicates and fed a basal maize-soyabean-meal diet (control, containing 47·0 mg Fe/kg) or the basal diet supplemented with 20, 40, 60, 80 or 100 mg Fe/kg from FeSO4.7H2O for 21 d. Regression analysis was performed to estimate the optimal dietary Fe level using quadratic models. Liver cytochrome c oxidase (Cox), heart Cox and kidney succinate dehydrogenase mRNA levels as well as heart COX activity were affected (P<0·08) by dietary Fe level, and COX mRNA level and activity in heart of broilers increased quadratically (P<0·03) as dietary Fe level increased. The estimates of dietary Fe requirements were 110 and 104 mg/kg for the full expression of Cox mRNA and for its activity in the heart of broilers, respectively. The results from this study indicate that COX mRNA level and activity in the heart are new and sensitive criteria to evaluate the dietary Fe requirements of broilers, and the dietary Fe requirements would be 104-110 mg/kg to support the full expression of COX in the heart of broiler chicks from 22 to 42 d of age, which are higher than the current National Research Council Fe requirement (80 mg/kg) of broiler chicks from 1 to 21 d or 22 to 42 d of age.
[Mh] Termos MeSH primário: Galinhas/fisiologia
Complexo IV da Cadeia de Transporte de Elétrons/metabolismo
Ferro na Dieta/administração & dosagem
Necessidades Nutricionais
[Mh] Termos MeSH secundário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Animais
Dieta/veterinária
Suplementos Nutricionais
Complexo IV da Cadeia de Transporte de Elétrons/genética
Coração/efeitos dos fármacos
Rim/efeitos dos fármacos
Rim/enzimologia
Fígado/efeitos dos fármacos
Fígado/enzimologia
Masculino
Miocárdio/enzimologia
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Feijão de Soja/química
Succinato Desidrogenase/genética
Succinato Desidrogenase/metabolismo
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Iron, Dietary); 0 (RNA, Messenger); EC 1.3.99.1 (Succinate Dehydrogenase); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002458


  5 / 2596 MEDLINE  
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[PMID]:28814396
[Au] Autor:Paganini D; Uyoga MA; Cercamondi CI; Moretti D; Mwasi E; Schwab C; Bechtler S; Mutuku FM; Galetti V; Lacroix C; Karanja S; Zimmermann MB
[Ad] Endereço:Laboratories of Human Nutrition and.
[Ti] Título:Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infants.
[So] Source:Am J Clin Nutr;106(4):1020-1031, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Whether consumption of prebiotics increases iron absorption in infants is unclear. We set out to determine whether prebiotic consumption affects iron absorption from a micronutrient powder (MNP) containing a mixture of ferrous fumarate and sodium iron EDTA (FeFum+NaFeEDTA) in Kenyan infants. Infants ( = 50; aged 6-14 mo) consumed maize porridge that was fortified with an MNP containing FeFum+NaFeEDTA and 7.5 g galacto-oligosaccharides (GOSs) (Fe+GOS group, = 22) or the same MNP without GOSs (Fe group, = 28) each day for 3 wk. Then, on 2 consecutive days, we fed all infants isotopically labeled maize porridge and MNP test meals containing 5 mg Fe as FeFum+Na FeEDTA or ferrous sulfate ( FeSO ). Iron absorption was measured as the erythrocyte incorporation of stable isotopes. Iron markers, fecal pH, and bacterial groups were assessed at baseline and 3 wk. Comparisons within and between groups were done with the use of mixed-effects models. There was a significant group-by-compound interaction on iron absorption ( = 0.011). The median percentages of fractional iron absorption from FeFum+NaFeEDTA and from FeSO in the Fe group were 11.6% (IQR: 6.9-19.9%) and 20.3% (IQR: 14.2-25.7%), respectively, ( < 0.001) and, in the Fe+GOS group, were 18.8% (IQR: 8.3-37.5%) and 25.5% (IQR: 15.1-37.8%), respectively ( = 0.124). Between groups, iron absorption was greater from the FeFum+NaFeEDTA ( = 0.047) in the Fe+GOS group but not from the FeSO ( = 0.653). The relative iron bioavailability from FeFum+NaFeEDTA compared with FeSO was higher in the Fe+GOS group than in the Fe group (88% compared with 63%; = 0.006). There was a significant time-by-group interaction on spp. ( = 0.008) and / / spp. ( = 0.018); / / spp. decreased in the Fe group ( = 0.013), and there was a nonsignificant trend toward higher spp. in the Fe+GOS group ( = 0.099). At 3 wk, iron absorption was negatively correlated with fecal pH ( < 0.001) and positively correlated with / / spp. ( = 0.001). GOS consumption by infants increased iron absorption by 62% from an MNP containing FeFum+NaFeEDTA, thereby possibly reflecting greater colonic iron absorption. This trial was registered at clinicaltrials.gov as NCT02666417.
[Mh] Termos MeSH primário: Compostos Férricos/sangue
Compostos Ferrosos/sangue
Alimentos Fortificados
Absorção Intestinal/efeitos dos fármacos
Ferro/sangue
Oligossacarídeos/farmacologia
Prebióticos
[Mh] Termos MeSH secundário: Anemia Ferropriva/sangue
Anemia Ferropriva/prevenção & controle
Bactérias/crescimento & desenvolvimento
Disponibilidade Biológica
Dieta
Ácido Edético/sangue
Eritrócitos/metabolismo
Feminino
Galactose/farmacologia
Seres Humanos
Lactente
Ferro/farmacocinética
Ferro na Dieta/metabolismo
Ferro na Dieta/farmacocinética
Isótopos
Quênia
Masculino
Micronutrientes
Oligoelementos/sangue
Oligoelementos/farmacocinética
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Ferrous Compounds); 0 (Iron, Dietary); 0 (Isotopes); 0 (Micronutrients); 0 (Oligosaccharides); 0 (Prebiotics); 0 (Trace Elements); 39R4TAN1VT (ferrous sulfate); 9G34HU7RV0 (Edetic Acid); E1UOL152H7 (Iron); KJ3C78Y22Z (Fe(III)-EDTA); R5L488RY0Q (ferrous fumarate); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.145060


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[PMID]:28659293
[Au] Autor:Lindberg J; Norman M; Westrup B; Domellöf M; Berglund SK
[Ad] Endereço:Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden; and.
[Ti] Título:Lower systolic blood pressure at age 7 y in low-birth-weight children who received iron supplements in infancy: results from a randomized controlled trial.
[So] Source:Am J Clin Nutr;106(2):475-480, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Low birth weight (LBW) (≤2500 g) is associated with iron deficiency in infancy and high blood pressure (BP) later in life. We investigated the effect of iron supplementation that was given to LBW infants on midchildhood BP. The study was a randomized, double-blind, controlled trial that included 285 marginally LBW (2000-2500-g) infants at 2 Swedish centers between May 2004 and November 2007. The infants were randomly assigned to receive a placebo or 1 or 2 mg Fe · kg · d from 6 wk to 6 mo of age. In secondary analyses at the age of 7 y, systolic blood pressure (SBP), diastolic blood pressure (DBP), and the prevalence of children with BP within the hypertensive range (>90th percentile) were compared between the groups. BP was analyzed via intention to treat in 189 children (66%). The mean ± SD SBP was 103 ± 8.1, 101 ± 7.5, and 101 ± 7.8 mm Hg in children who had received the placebo ( = 70), 1 mg Fe · kg · d ( = 54), or 2 mg Fe · kg · d ( = 65), respectively. When the iron-supplemented groups were combined in covariate-adjusted analyses, the mean SBP in LBW children who had received iron supplementation in infancy was 2.2 mm Hg (95% CI: 0.3, 4.2 mm Hg) lower than in those who were unsupplemented ( = 0.026). Multivariate logistic regression showed that iron supplementation in infancy reduced the odds of having an SBP within the hypertensive range at 7 y of age (OR: 0.32; 95% CI: 0.11, 0.96). For DBP, there were no significant differences between the intervention groups. LBW children who receive iron supplementation (1 or 2 mg Fe · kg · d ) in infancy have lower SBP at 7 y. This (to our knowledge) novel observation suggests that the increased risk of hypertension that is observed in children and adults who are born small might be reduced with early micronutrient interventions. This trial was registered at clinicaltrials.gov as NCT00558454.
[Mh] Termos MeSH primário: Pressão Sanguínea/efeitos dos fármacos
Suplementos Nutricionais
Hipertensão/prevenção & controle
Recém-Nascido de Baixo Peso
Ferro na Dieta/uso terapêutico
Ferro/uso terapêutico
Cuidado Pós-Natal
[Mh] Termos MeSH secundário: Anemia Ferropriva/tratamento farmacológico
Anemia Ferropriva/etiologia
Criança
Método Duplo-Cego
Feminino
Seres Humanos
Hipertensão/epidemiologia
Lactente
Ferro/farmacologia
Ferro na Dieta/farmacologia
Modelos Logísticos
Masculino
Análise Multivariada
Razão de Chances
Oligoelementos/farmacologia
Oligoelementos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Iron, Dietary); 0 (Trace Elements); E1UOL152H7 (Iron)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.150482


  7 / 2596 MEDLINE  
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[PMID]:28615456
[Au] Autor:Coffey R; Ganz T
[Ad] Endereço:From the Departments of Medicine and Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1690.
[Ti] Título:Iron homeostasis: An anthropocentric perspective.
[So] Source:J Biol Chem;292(31):12727-12734, 2017 Aug 04.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels. Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin. Hepcidin is feedback-regulated by iron status and strongly modulated by inflammation and erythropoietic demand. This review highlights recent advances that have changed our understanding of iron metabolism and its regulation.
[Mh] Termos MeSH primário: Homeostase
Ferro/fisiologia
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte de Cátions/fisiologia
Eritropoese
Hepcidinas/fisiologia
Seres Humanos
Imunidade Inata
Absorção Intestinal
Ferro/sangue
Ferro na Dieta/efeitos adversos
Ferro na Dieta/metabolismo
Fígado/fisiologia
Macrófagos/imunologia
Macrófagos/fisiologia
Estado Nutricional
Comunicação Parácrina
Receptores da Transferrina/agonistas
Receptores da Transferrina/fisiologia
Transdução de Sinais
Transferrina/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cation Transport Proteins); 0 (HAMP protein, human); 0 (Hepcidins); 0 (Iron, Dietary); 0 (Receptors, Transferrin); 0 (Transferrin); 0 (metal transporting protein 1); E1UOL152H7 (Iron)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.R117.781823


  8 / 2596 MEDLINE  
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[PMID]:28615441
[Au] Autor:Knutson MD
[Ad] Endereço:From the Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611-03170 mknutson@ufl.edu.
[Ti] Título:Iron transport proteins: Gateways of cellular and systemic iron homeostasis.
[So] Source:J Biol Chem;292(31):12735-12743, 2017 Aug 04.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellular iron homeostasis is maintained by iron and heme transport proteins that work in concert with ferrireductases, ferroxidases, and chaperones to direct the movement of iron into, within, and out of cells. Systemic iron homeostasis is regulated by the liver-derived peptide hormone, hepcidin. The interface between cellular and systemic iron homeostasis is readily observed in the highly dynamic iron handling of four main cell types: duodenal enterocytes, erythrocyte precursors, macrophages, and hepatocytes. This review provides an overview of how these cell types handle iron, highlighting how iron and heme transporters mediate the exchange and distribution of body iron in health and disease.
[Mh] Termos MeSH primário: Homeostase
Ferro/fisiologia
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Duodeno/citologia
Duodeno/fisiologia
Enterócitos/fisiologia
Células Precursoras Eritroides/citologia
Células Precursoras Eritroides/fisiologia
Eritropoese
Heme/efeitos adversos
Heme/metabolismo
Hepatócitos/fisiologia
Hepcidinas/fisiologia
Seres Humanos
Absorção Intestinal
Mucosa Intestinal/citologia
Mucosa Intestinal/fisiologia
Ferro/sangue
Ferro na Dieta/efeitos adversos
Ferro na Dieta/metabolismo
Macrófagos/imunologia
Macrófagos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HAMP protein, human); 0 (Hepcidins); 0 (Iron, Dietary); 42VZT0U6YR (Heme); E1UOL152H7 (Iron)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.R117.786632


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[PMID]:28615372
[Au] Autor:Nguyen PH; Gonzalez-Casanova I; Young MF; Truong TV; Hoang H; Nguyen H; Nguyen S; DiGirolamo AM; Martorell R; Ramakrishnan U
[Ad] Endereço:International Food Policy Research Institute, Washington, DC; p.h.nguyen@cgiar.org.
[Ti] Título:Preconception Micronutrient Supplementation with Iron and Folic Acid Compared with Folic Acid Alone Affects Linear Growth and Fine Motor Development at 2 Years of Age: A Randomized Controlled Trial in Vietnam.
[So] Source:J Nutr;147(8):1593-1601, 2017 Aug.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maternal health and nutrition play a crucial role in early child growth and development. However, little is known about the benefits of preconception micronutrient interventions beyond the role of folic acid (FA) and neural tube defects. We evaluated the impact of weekly preconception multiple micronutrient (MM) or iron and folic acid (IFA) supplementation on child growth and development through the age of 2 y compared with FA alone. We followed 1599 offspring born to women who participated in a randomized controlled trial of preconception supplementation in Vietnam. Women received weekly supplements that contained either 2800 µg FA, 60 mg Fe and 2800 µg FA, or 15 MMs including IFA, from baseline until conception followed by daily prenatal IFA supplements until delivery. Child anthropometry was measured at birth and at 3, 6, 12, 18, and 24 mo. Child development was measured with the use of the Bayley Scales for Infant Development III at 24 mo. The groups were similar for baseline maternal and offspring birth characteristics. At 24 mo of age, the offspring in the IFA group had significantly higher length-for-age scores (LAZs) (0.14; 95% CI: 0.03, 0.26), reduced risk of being stunted (0.87; 95% CI: 0.76, 0.99), and smaller yearly decline in LAZs (0.10; 95% CI: 0.04, 0.15) than the offspring in the FA group. Similar trends were found for the offspring in the MM group compared with the FA group for LAZs (0.10; 95% CI: -0.02, 0.22) and the risk of being stunted (0.88; 95% CI: 0.77, 1.01). Offspring in the IFA group had improved motor development ( = 0.03), especially fine motor development (0.41; 95% CI: 0.05, 0.77), at the age of 24 mo, but there were no differences for measures of cognition or language. Preconception supplementation with IFA improved linear growth and fine motor development at 2 y of age compared with FA. Future studies should examine whether these effects persist and improve child health and schooling. The trial was registered at clinicaltrials.gov as NCT01665378.
[Mh] Termos MeSH primário: Estatura
Desenvolvimento Infantil
Suplementos Nutricionais
Ácido Fólico/uso terapêutico
Ferro/uso terapêutico
Destreza Motora
Cuidado Pré-Concepcional
[Mh] Termos MeSH secundário: Pré-Escolar
Transtornos do Crescimento/prevenção & controle
Seres Humanos
Lactente
Ferro na Dieta/uso terapêutico
Masculino
Micronutrientes/uso terapêutico
Estado Nutricional
Vietnã
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Iron, Dietary); 0 (Micronutrients); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.250597


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[PMID]:28490515
[Au] Autor:Karakochuk CD; Barker MK; Whitfield KC; Barr SI; Vercauteren SM; Devlin AM; Hutcheon JA; Houghton LA; Prak S; Hou K; Chai TL; Stormer A; Ly S; Devenish R; Oberkanins C; Pühringer H; Harding KB; De-Regil LM; Kraemer K; Green TJ
[Ad] Endereço:Food, Nutrition, and Health and Departments of.
[Ti] Título:The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: a 2 x 2 factorial, double-blind, randomized controlled supplementation trial.
[So] Source:Am J Clin Nutr;106(1):233-244, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite a high prevalence of anemia among nonpregnant Cambodian women, current reports suggest that iron deficiency (ID) prevalence is low. If true, iron supplementation will not be an effective anemia reduction strategy. We measured the effect of daily oral iron with or without multiple micronutrients (MMNs) on hemoglobin concentration in nonpregnant Cambodian women screened as anemic. In this 2 × 2 factorial, double-blind, randomized trial, nonpregnant women (aged 18-45 y) with hemoglobin concentrations ≤117 g/L (capillary blood) were recruited from 26 villages in Kampong Chhnang province and randomly assigned to receive 12 wk of iron (60 mg; Fe group), MMNs (14 other micronutrients; MMN group), iron plus MMNs (Fe+MMN group), or placebo capsules. A 2 × 2 factorial intention-to-treat analysis with the use of a generalized mixed-effects model was used to assess the effects of iron and MMNs and the interaction between these factors. In July 2015, 809 women were recruited and 760 (94%) completed the trial. Baseline anemia prevalence was 58% (venous blood). Mean (95% CI) hemoglobin concentrations at 12 wk in the Fe, MMN, Fe+MMN, and placebo groups were 121 (120, 121), 116 (116, 117), 123 (122, 123), and 116 (116, 117) g/L, with no iron × MMN interaction ( = 0.66). Mean (95% CI) increases in hemoglobin were 5.6 g/L (3.8, 7.4 g/L) ( < 0.001) among women who received iron ( = 407) and 1.2 g/L (-0.6, 3.0 g/L) ( = 0.18) among women who received MMNs ( = 407). The predicted proportions (95% CIs) of women with a hemoglobin response (≥10 g/L at 12 wk) were 19% (14%, 24%), 9% (5%, 12%), 30% (24%, 35%), and 5% (2%, 9%) in the Fe, MMN, Fe+MMN, and placebo groups, respectively. Daily iron supplementation for 12 wk increased hemoglobin in nonpregnant Cambodian women; however, MMNs did not confer additional significant benefit. Overall, ∼24% of women who received iron responded after 12 wk; even fewer would be likely to respond in the wider population. This trial was registered at clinicaltrials.gov as NCT02481375.
[Mh] Termos MeSH primário: Anemia/tratamento farmacológico
Suplementos Nutricionais
Hemoglobinas/metabolismo
Ferro na Dieta/uso terapêutico
Ferro/uso terapêutico
Micronutrientes/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Anemia/epidemiologia
Anemia Ferropriva/tratamento farmacológico
Camboja/epidemiologia
Método Duplo-Cego
Feminino
Seres Humanos
Ferro/farmacologia
Ferro na Dieta/farmacologia
Micronutrientes/farmacologia
Meia-Idade
Reprodução
Complexo Vitamínico B/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Iron, Dietary); 0 (Micronutrients); 12001-76-2 (Vitamin B Complex); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.140996



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