Base de dados : MEDLINE
Pesquisa : D01.496.749 [Categoria DeCS]
Referências encontradas : 27028 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2703 ir para página                         

  1 / 27028 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29400037
[Au] Autor:Estêvão R; Duarte H; Lopes F; Fernandes J; Monteiro E
[Ti] Título:Peptide receptor radionuclide therapy in head and neck paragangliomas ­ Report of 14 cases.
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(4):155-8, 2015.
[Is] ISSN:0035-1334
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Background: Peptide receptor radionuclide therapy (PRRT) is a very promising treatment option in neuroendocrine tumours, with good results, but there are only few reports regar­ding its use in paragangliomas. Methods: The authors conduc­ted a retrospective study during the period of May 2011 to February 2014 in an Oncological Centre. Ten patients with jugular-tympanic paragangliomas and four with carotid body paragangliomas were treated with three cycles of Lutetium labelled peptide (177 Lu-DOTATATE). Treatment response was assessed with a PET-CT with 68 Ga-DOTANOC and clinical crite­ria. Results: Ten of the fourteen patients showed a decrea­se in the tumor standard uptake value (SUV) after treat­ment. 90% of patients with Jugulotympanic paraganglio­mas had symptomatic improvement or stabilization. Patients with carotid body paragangliomas and patients with a low uptake of 68 Ga-DOTANOC had a worse response to the treatment. The tumor SUV value was a predictor of treatment response [R= 0,64; F= 8,212; p= 0,014]. Conclusion: Peptide receptor radio­nuclide therapy can be a therapeutic option in selected cases of head and neck paragangliomas.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/radioterapia
Lutécio/uso terapêutico
Paraganglioma/radioterapia
Radioisótopos/uso terapêutico
Compostos Radiofarmacêuticos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Masculino
Meia-Idade
Paraganglioma/diagnóstico por imagem
Paraganglioma/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lutetium-177); 0 (Radioisotopes); 0 (Radiopharmaceuticals); 5H0DOZ21UJ (Lutetium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


  2 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29241166
[Au] Autor:De Luca R; Costa RP; Tripoli V; Murabito A; Cicero G
[Ad] Endereço:Department of Surgical, Oncological, and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy.
[Ti] Título:The Clinical Efficacy of Radium-223 for Bone Metastasis in Patients with Castration-Resistant Prostate Cancer: An Italian Clinical Experience.
[So] Source:Oncology;94(3):161-166, 2018.
[Is] ISSN:1423-0232
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Prostate cancer frequently causes bone metastases and skeletal events that impair quality of life (QoL) and survival. The alpha emitter radium-223 is a new drug that improves treatment in men with castration-resistant prostate cancer (CRPC) and bone metastases. Our aim was to evaluate the effectiveness of radium-223. SUBJECTS AND METHODS: In this retrospective study we enrolled 48 subjects. Pain reduction, alkaline phosphatase (ALP), time to first symptomatic skeletal event, and QoL were the variables we evaluated. RESULTS: Radium-223 was well tolerated, with a manageable toxicity profile and a modest objective response rate. A considerable difference in serum ALP levels before and after treatment was observed, with a significant correlation between pain relief and QoL, which showed a value of R2 to 0.44 with a slope of 1.50 (p = 0.0021). CONCLUSIONS: Radium-223 showed a clinical benefit, with a reduction in pain symptoms in 58% of patients. Radium-223 was shown to be an effective and well-tolerated therapeutic option in patients with metastatic CRPC progressing after docetaxel plus prednisone treatment.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Neoplasias Ósseas/tratamento farmacológico
Neoplasias Ósseas/secundário
Neoplasias de Próstata Resistentes à Castração/patologia
Radioisótopos/uso terapêutico
Rádio (Elemento)/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Seres Humanos
Itália
Masculino
Meia-Idade
Prednisona/uso terapêutico
Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico
Qualidade de Vida
Estudos Retrospectivos
Taxoides/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Radioisotopes); 0 (Radium-223); 0 (Taxoids); 15H5577CQD (docetaxel); VB0R961HZT (Prednisone); W90AYD6R3Q (Radium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1159/000485102


  3 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28749808
[Au] Autor:Ohba T; Hasegawa A; Kohayagawa Y; Kondo H; Suzuki G
[Ad] Endereço:*Department of Radiation Health Management, Fukushima Medical University, Fukushima, Japan; †ISGlobal (Institut de Salut Global de Barcelona), Barcelona, Spain; ‡Department of Radiation Disaster Mediceine, Fukushima Medical University, Fukushima, Japan; §National Hospital Organization Disaster Medical Center, Tokyo, Japan; **International University of Health and Welfare Clinic, Tochigi, Japan.
[Ti] Título:Body Surface Contamination Levels of Residents under Different Evacuation Scenarios after the Fukushima Daiichi Nuclear Power Plant Accident.
[So] Source:Health Phys;113(3):175-182, 2017 09.
[Is] ISSN:1538-5159
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Body surface contamination levels should be correlated with inhaled actual thyroid doses during evacuation following the Fukushima Daiichi nuclear power plant (FDNPP) accident. Evacuees and residents were screened for body surface contamination using a Geiger-Mueller survey meter. The authors obtained 7,539 individual screening data sheets as well as gamma-spectrometry data from measurements made on clothing of two subjects by using a germanium spectrometer. Body surface contamination levels were analyzed in four residential groups during two different periods: 12-14 and 15-17 March 2011. Contamination levels during 12-14 March in the Tomioka/Okuma/Futaba/Naraha group were very low, indicating that residents evacuated before the radioactive plume reached their towns on 12 March. In contrast, levels in the Namie and Minamisoma groups were higher than those in the other groups in both periods, indicating that these residents were exposed to plumes twice on 12 and 15-16 March. The plume on 12 March was enriched with short-lived radionuclides: averaged proportions of radioactivity (relative to I) from Te, I, and Cs measured in clothing from two subjects were 2.3, 1.1, and 0.1, respectively, after correction for physical decay by 12:00 on 12 March. These proportions are similar to those (relative to I) from Te and Cs in dust sampled by a high-volume air sampler in the zone 20 km from the FDNPP on 12 March: 1.9 and 0.1, respectively. These data indicate that the relative contribution to inhaled thyroid dose of short-lived radionuclides in radioactive plumes released on 12 March could be as much as 37.5% in 1-y-old children.
[Mh] Termos MeSH primário: Acidente Nuclear de Fukushima
Habitação
Centrais Nucleares
Monitoramento de Radiação/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Meia-Vida
Seres Humanos
Lactente
Recém-Nascido
Japão
Masculino
Meia-Idade
Radioisótopos/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Radioisotopes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1097/HP.0000000000000690


  4 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29222990
[Au] Autor:Ryken N; Al-Barri B; Blake W; Taylor A; Tack FMG; Van Ranst E; Bodé S; Boeckx P; Verdoodt A
[Ad] Endereço:Department of Soil Management, Ghent University, Ghent, Belgium. Electronic address: nick.ryken@ugent.be.
[Ti] Título:Rapid and irreversible sorption behavior of Be assessed to evaluate its use as a catchment sediment tracer.
[So] Source:J Environ Radioact;182:108-116, 2018 Feb.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Beryllium-7 ( Be) has been used as a sediment tracer to evaluate soil redistribution rates at hillslopes and as a tool to estimate sediment residence time in river systems. A key assumption for the use of Be as a sediment tracer is the rapid and irreversible sorption of Be upon contact with the soil particles. However, recent studies have raised questions about the validity of these assumptions. Seven soil types were selected to assess the adsorption rate of Be on the soil particles, subsequently an extraction experiment was performed to assess the rate of desorption. Next, different treatments were applied to assess the impact of soil pH, fertilizer, humic acid and organic matter on the adsorption of Be. Finally, the influence of regularly occurring cations present on the soil complex on the adsorption of Be on pure clay minerals was evaluated. The adsorption rate experiment showed a rapid and nearly complete sorption of Be for Luvisols and Cambisols under agriculture. For a temperate climate Stagnosol under forest and two highly weathered tropical Ferralsols sorption of Be was less rapid and less complete. This may result in an incomplete adsorption of Be on these three soils when runoff initiates, which could lead to an overestimation of erosion rates and sediment residence time. Additional observations were made during the extraction experiment, showing a significant loss of Be from the forest Stagnosol and a stable binding of Be to the arable soils. Of the different treatments applied, only pH showed to be of influence. Finally, Ca and NH on the soil complex had only a limited effect on the adsorption of Be, while Al in combination with a low pH inhibits the adsorption of Be on the exchange complex of the pure clay minerals. All these findings more rigorously support the use of Be as a soil redistribution tracer in arable soils in a temperate climate at a hillslope scale. The use of Be in highly weathered Ferralsols or forest rich environments should be limited to avoid overestimations of erosion rates. The spatially extended use of Be to evaluate residence times of sediments should be avoided in catchments with rapid changing environmental parameters as they might influence the sorption behavior of Be.
[Mh] Termos MeSH primário: Berílio/análise
Monitoramento de Radiação/métodos
Radioisótopos/análise
Poluentes Radioativos do Solo/análise
[Mh] Termos MeSH secundário: Adsorção
Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Beryllium-7); 0 (Radioisotopes); 0 (Soil Pollutants, Radioactive); OW5102UV6N (Beryllium)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


  5 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29175006
[Au] Autor:Viner BJ; Jannik T; Hepworth A; Adetona O; Naeher L; Eddy T; Doman E; Blake J
[Ad] Endereço:Savannah River National Laboratory, USA. Electronic address: brian.viner@srnl.doe.gov.
[Ti] Título:Predicted cumulative dose to firefighters and the offsite public from natural and anthropogenic radionuclides in smoke from wildland fires at the Savannah River Site, South Carolina USA.
[So] Source:J Environ Radioact;182:1-11, 2018 Feb.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The contaminated ground surface at Savannah River Site (SRS) is a result of the decades of work that has been performed maintaining the country's nuclear stockpile and performing research and development on nuclear materials. The volatilization of radionuclides during wildfire results in airborne particles that are dispersed within the smoke plume and may result in doses to downwind firefighters and the public. To better understand the risk that these smoke plumes present, we have characterized four regions at SRS in terms of their fuel characteristics and radiological contamination on the ground. Combined with general meteorological conditions describing typical and extreme burn conditions, we have simulated potential fires in these regions and predicted the potential radiological dose that could be received by firefighting personnel and the public surrounding the SRS. In all cases, the predicted cumulative dose was a small percent of the US Department of Energy regulatory limit (0.25 mSv). These predictions were conservative and assumed that firefighters would be exposed for the duration of their shift and the public would be exposed for the entire day over the duration of the burn. Realistically, firefighters routinely rotate off the firefront during their shift and the public would likely remain indoors much of the day. However, we show that even under worst-case conditions the regulatory limits are not exceeded. We can infer that the risks associated with wildfires would not be expected to cause cumulative doses above the level of concern to either responding personnel or the offsite public.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Poluentes Radioativos do Ar/análise
Contaminação Radioativa do Ar/estatística & dados numéricos
Exposição Ocupacional/estatística & dados numéricos
Incêndios Florestais/estatística & dados numéricos
[Mh] Termos MeSH secundário: Bombeiros
Radioisótopos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Air Pollutants, Radioactive); 0 (Radioisotopes)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  6 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29025554
[Au] Autor:Aquaro GD; Perfetti M; Camastra G; Monti L; Dellegrottaglie S; Moro C; Pepe A; Todiere G; Lanzillo C; Scatteia A; Di Roma M; Pontone G; Perazzolo Marra M; Barison A; Di Bella G; Cardiac Magnetic Resonance Working Group of the Italian Society of Cardiology
[Ad] Endereço:Gabriele Monasterio Foundation, Tuscan Region, Pisa, Italy. Electronic address: aquaro@ftgm.it.
[Ti] Título:Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis With Preserved Systolic Function: ITAMY Study.
[So] Source:J Am Coll Cardiol;70(16):1977-1987, 2017 Oct 17.
[Is] ISSN:1558-3597
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prognostic role of cardiac magnetic resonance (CMR) and late gadolinium enhancement (LGE) has not been clarified in acute myocarditis (AM) with preserved left ventricular (LV) ejection fraction (EF). OBJECTIVES: This study sought to evaluate the role of CMR and LGE in the prognosis of AM with preserved LVEF. METHODS: This study analyzed data from ITAMY (ITalian multicenter study on Acute MYocarditis) and evaluated CMR results from 386 patients (299 male; mean age 35 ± 15 years) with AM and preserved LVEF. Clinical follow-up was performed for a median of 1,572 days. A clinical combined endpoint of cardiac death, appropriate implantable cardioverter-defibrillator firing, resuscitated cardiac arrest, and hospitalization for heart failure was used. RESULTS: Among the 374 patients with suitable images, LGE involved the subepicardial layer inferior and lateral wall in 154 patients (41%; IL group), the midwall layer of the anteroseptal wall in 135 patients (36%; AS [anteroseptal] group), and other segments in 59 patients (16%; other-LGE group), and it was absent in 26 patients (no-LGE group). The AS group had a greater extent of LGE and a higher LV end-diastolic volume index than other groups, but levels of inflammatory markers were lower than in the other groups. Kaplan-Meier curve analysis indicated that the AS group had a worse prognosis than the other groups (p < 0.0001). Finally, in multivariable analysis, AS LGE was the best independent CMR predictor of the combined endpoint (odds ratio: 2.73; 95% confidence interval: 1.2 to 5.9; p = 0.01). CONCLUSIONS: In patients with AM and preserved LVEF, LGE in the midwall layer of the AS myocardial segment is associated with a worse prognosis than other patterns of presentation.
[Mh] Termos MeSH primário: Gadolínio
Imagem Cinética por Ressonância Magnética/métodos
Miocardite/diagnóstico por imagem
Miocardite/epidemiologia
Radioisótopos
Função Ventricular Esquerda/fisiologia
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Angiografia Coronária/métodos
Feminino
Seguimentos
Seres Humanos
Itália/epidemiologia
Masculino
Meia-Idade
Miocardite/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Radioisotopes); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  7 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28910626
[Au] Autor:Vaasma T; Kaasik M; Loosaar J; Kiisk M; Tkaczyk AH
[Ad] Endereço:Institute of Physics, University of Tartu, W. Ostwaldi 1, 50411 Tartu, Estonia. Electronic address: taavi.vaasma@ut.ee.
[Ti] Título:Long-term modelling of fly ash and radionuclide emissions as well as deposition fluxes due to the operation of large oil shale-fired power plants.
[So] Source:J Environ Radioact;178-179:232-244, 2017 Nov.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two of the world's largest oil shale-fired power plants (PPs) in Estonia have been operational over 40 years, emitting various pollutants, such as fly ash, SO , NO , heavy metals, volatile organic compounds as well as radionuclides to the environment. The emissions from these PPs have varied significantly during this period, with the maximum during the 1970s and 1980s. The oil shale burned in the PPs contains naturally occurring radionuclides from the U and Th decay series as well as K. These radionuclides become enriched in fly ash fractions (up to 10 times), especially in the fine fly ash escaping the purification system. Using a validated Gaussian-plume model, atmospheric dispersion modelling was carried out to determine the quantity and a real magnitude of fly ash and radionuclide deposition fluxes during different decades. The maximum deposition fluxes of volatile radionuclides ( Pb and Po) were around 70 mBq m d nearby the PPs during 1970s and 1980s. Due to the reduction of burned oil shale and significant renovations done on the PPs, the deposition fluxes were reduced to 10 mBq m d in the 2000s and down to 1.5 mBq m d in 2015. The maximum deposition occurs within couple of kilometers of the PPs, but the impacted area extends to over 50 km from the sources. For many radionuclides, including Po, the PPs have been larger contributors of radionuclides to the environment via atmospheric pathway than natural sources. This is the first time that the emissions and deposition fluxes of radionuclides from the PPs have been quantified, providing the information about their radionuclide deposition load on the surrounding environment during various time periods.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Cinza de Carvão/análise
Modelos Químicos
Monitoramento de Radiação
Radioisótopos/análise
[Mh] Termos MeSH secundário: Estônia
Centrais Elétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Radioactive); 0 (Coal Ash); 0 (Radioisotopes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE


  8 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28898054
[Au] Autor:Müller C; Farkas R; Borgna F; Schmid RM; Benesová M; Schibli R
[Ad] Endereço:Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut , 5232 Villigen-PSI, Switzerland.
[Ti] Título:Synthesis, Radiolabeling, and Characterization of Plasma Protein-Binding Ligands: Potential Tools for Modulation of the Pharmacokinetic Properties of (Radio)Pharmaceuticals.
[So] Source:Bioconjug Chem;28(9):2372-2383, 2017 Sep 20.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The development of (radio)pharmaceuticals with favorable pharmacokinetic profiles is crucial for allowing the optimization of the imaging or therapeutic potential and the minimization of undesired side effects. The aim of this study was, therefore, to evaluate and compare three different plasma protein binders (PPB-01, PPB-02, and PPB-03) that are potentially useful in combination with (radio)pharmaceuticals to enhance their half-life in the blood. The entities were functionalized with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator via a l-lysine and ß-alanine linker moiety using solid-phase peptide chemistry and labeled with Lu (T = 6.65 days), a clinically established radiometal. The binding capacities of these radioligands and Lu-DOTA were evaluated using human plasma and solutions of human serum albumin (HSA), human α -acid glycoprotein (α -AGP), and human transthyretin (hTTR) by applying an ultrafiltration assay. Lu-DOTA-PPB-01 and Lu-DOTA-PPB-02 bound to a high and moderate extent to human plasma proteins (>90% and ∼70%, respectively), whereas the binding to hTTR was considered negligible (<10%). Lu-DOTA-PPB-03 showed almost complete binding to human plasma proteins (>90%) with a high fraction bound to hTTR (∼50%). Plasma protein binding of the Lu-DOTA complex, which was used as a control, was not observed (<1%). Lu-DOTA-PPB-01 and Lu-DOTA-PPB-02 were both displaced (>80%) from HSA by ibuprofen, specific for Sudlow's binding site II and coherent with the aromatic structures, and >80% by their respective binding entities. Lu-DOTA-PPB-03 was displaced from hTTR by the site-marker l-thyroxine (>60%) and by its binding entity PPB-03* (>80%). All three radioligands were investigated with regard to the in vivo blood clearance in normal mice. Lu-DOTA-PPB-01 showed the slowest blood clearance (T : >15 h) followed by Lu-DOTA-PPB-03 (T : ∼2.33 h) and Lu-DOTA-PPB-02 (T : ∼1.14 h), which was excreted relatively fast. Our results confirmed the high affinity of the 4-(4-iodophenyl)-butyric acid entity (PPB-01) to plasma proteins, while replacement of the halogen by an ethynyl entity (PPB-02) reduced the plasma protein binding significantly. An attractive approach is the application of the transthyretin binder (PPB-03), which shows high affinity to hTTR. Future studies in our laboratory will be focused on the application of these binding entities in combination with clinically relevant targeting agents for diagnostic and therapeutic purposes in nuclear medicine.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/metabolismo
Lutécio/metabolismo
Compostos Radiofarmacêuticos/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Ligantes
Lutécio/química
Lutécio/farmacocinética
Camundongos Endogâmicos BALB C
Pré-Albumina/metabolismo
Ligação Proteica
Radioisótopos/química
Radioisótopos/metabolismo
Radioisótopos/farmacocinética
Compostos Radiofarmacêuticos/química
Compostos Radiofarmacêuticos/farmacocinética
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único/métodos
Tiroxina/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Ligands); 0 (Prealbumin); 0 (Radioisotopes); 0 (Radiopharmaceuticals); 5H0DOZ21UJ (Lutetium); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00378


  9 / 27028 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28864619
[Au] Autor:Müller C; van der Meulen NP; Benesová M; Schibli R
[Ad] Endereço:Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut, Villigen-PSA, Switzerland.
[Ti] Título:Therapeutic Radiometals Beyond Lu and Y: Production and Application of Promising α-Particle, ß -Particle, and Auger Electron Emitters.
[So] Source:J Nucl Med;58(Suppl 2):91S-96S, 2017 Sep.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years, new α-particle-, ß -particle-, and Auger electron-emitting radiometals-such as Cu, Sc, Ho, Tb, Tb, Pb/ Bi, Ac, and Bi-have been produced and evaluated (pre)clinically for therapeutic purposes. In this short review article, the most important routes of production of these radiometals are critically discussed, as are examples of their application in preclinical and clinical studies.
[Mh] Termos MeSH primário: Partículas alfa/uso terapêutico
Partículas beta/uso terapêutico
Elétrons
Metais/química
Radioquímica/métodos
Radioisótopos/química
Radioisótopos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Metals); 0 (Radioisotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.186825


  10 / 27028 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28864612
[Au] Autor:Levine R; Krenning EP
[Ad] Endereço:Corporate Communications, Advanced Accelerator Applications, S.A., New York, New York; and rachel.levine@adacap.com.
[Ti] Título:Clinical History of the Theranostic Radionuclide Approach to Neuroendocrine Tumors and Other Types of Cancer: Historical Review Based on an Interview of Eric P. Krenning by Rachel Levine.
[So] Source:J Nucl Med;58(Suppl 2):3S-9S, 2017 Sep.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In nuclear medicine, the term describes the combination of therapy and diagnostic imaging. In practice, this concept dates back more than 50 years; however, among the most successful examples of theranostics are peptide receptor scintigraphy and peptide receptor radionuclide therapy of neuroendocrine tumors. The development of these modalities through the radiolabeling of somatostatin analogs with various radionuclides has led to a revolution in patient management and established a foundation for expansion of the theranostic principle into other oncology indications. This article provides a review of the evolution and development of the theranostic radionuclide approach to the management of neuroendocrine tumors, as described by the inventor of this technique, Eric P. Krenning, in an interview with Rachel Levine.
[Mh] Termos MeSH primário: Diagnóstico
Tumores Neuroendócrinos/diagnóstico
Tumores Neuroendócrinos/radioterapia
Radioisótopos/uso terapêutico
Radioterapia/história
[Mh] Termos MeSH secundário: História do Século XX
História do Século XXI
Seres Humanos
Entrevistas como Assunto
Marcação por Isótopo
Receptores de Peptídeos/metabolismo
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radioisotopes); 0 (Receptors, Peptide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.186502



página 1 de 2703 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde