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Pesquisa : D01.496.749.731 [Categoria DeCS]
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[PMID]:28456080
[Au] Autor:Tang C; Nie D; Tang G; Gao S; Liu S; Wen F; Tang X
[Ad] Endereço:Guangdong Engineering Research Center for Medical Radiopharmaceuticals Translational Application PET-CT Center and Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; Department of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-Se
[Ti] Título:Radiosynthesis and biological evaluation of N-(2-[ F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine as a PET tracer for oncologic imaging.
[So] Source:Nucl Med Biol;50:39-46, 2017 Jul.
[Is] ISSN:1872-9614
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Several C and F labeled 3,4-dihydroxy-l-phenylalanine (l-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, F-labeled N-substituted l-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new F-labeled l-DOPA analogue, N-(2-[ F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine ([ F]FPDOPA) for tumor PET imaging are performed. METHODS: The synthesis of [ F]FPDOPA was via a two-step reaction sequence from 4-nitrophenyl-2-[ F]fluoropropionate ([ F]NFP). The biodistribution of [ F]FPDOPA was determined in normal Kunming mice. In vitro competitive inhibition and protein incorporation experiments were performed with SPC-A-1 lung adenocarcinoma cell lines. PET/CT studies of [ F]FPDOPA were conducted in C6 rat glioma and SPC-A-1 human lung adenocarcinoma and H460 human large cell lung cancer-bearing nude mice. RESULTS: [ F]FPDOPA was prepared with a decay-corrected radiochemical yield of 28±5% and a specific activity of 50±15GBq/µmol (n=10) within 125min. In vitro cell experiments showed that [ F]FPDOPA uptake in SPC-A-1 cells was primarily transported through Na -independent system L, with Na -dependent system B and system ASC partly involved in it. Biodistribution data in mice showed that renal-bladder route was the main excretory system of [ F]FPDOPA. PET imaging demonstrated intense accumulation of [ F]FPDOPA in several tumor xenografts, with (8.50±0.40)%ID/g in C6 glioma, (6.30±0.12)%ID/g in SPC-A-1 lung adenocarcinoma, and (6.50±0.10)%ID/g in H460 large cell lung cancer, respectively. CONCLUSION: A novel N-substituted F-labeled L-DOPA analogue [ F]FPDOPA is synthesized and evaluated in vitro and in vivo. The results support that [ F]FPDOPA seems to be a potential PET tracer for tumor imaging, especially be a better potential PET tracer than [ F]fluoro-2-deoxy-d-glucose ([ F]FDG) for brain tumor imaging.
[Mh] Termos MeSH primário: Neoplasias/diagnóstico por imagem
Fenilalanina/análogos & derivados
Fenilalanina/síntese química
Fenilalanina/farmacocinética
Tomografia por Emissão de Pósitrons
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Técnicas de Química Sintética
Estabilidade de Medicamentos
Seres Humanos
Camundongos
Neoplasias/metabolismo
Fenilalanina/química
Traçadores Radioativos
Radioquímica
Ratos
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radioactive Tracers); 47E5O17Y3R (Phenylalanine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28888821
[Au] Autor:Kumata K; Yui J; Zhang Y; Kurihara Y; Ogawa M; Mori W; Fujinaga M; Zhang MR
[Ad] Endereço:Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
[Ti] Título:[ C]BCTC: Radiosynthesis and in vivo binding to transient receptor potential vanilloid subfamily member 1 (TRPV1) receptor in the mouse trigeminal nerve.
[So] Source:Bioorg Med Chem Lett;27(19):4521-4524, 2017 10 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to synthesize a new positron emission tomography radiotracer, N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-[ C]carboxamide ([ C]BCTC, [ C]1), and assess its in vivo binding to the transient receptor potential vanilloid subfamily member 1 (TRPV1) receptor in mice. [ C]BCTC was synthesized by reacting the hydrochloride of 4-tertiarybutylaniline (2·HCl) with [ C]phosgene ([ C]COCl ) to give isocyanate [ C]4, followed by reaction with 4-(3-chloropyridin-2-yl)tetrahydropyrazine (3). [ C]BCTC was obtained at a 16-20% radiochemical yield, based on the cyclotron-produced [ C]CO (decay-corrected to the end of bombardment), with >98% radiochemical purity and 65-110GBq/µmol specific activity at the end of synthesis. An ex vivo biodistribution study in mice confirmed the specific binding of [ C]BCTC to TRPV1 in the trigeminal nerve, which is a tissue with high TRPV1 expression.
[Mh] Termos MeSH primário: Pirazinas/farmacocinética
Piridinas/farmacocinética
Canais de Cátion TRPV/química
Nervo Trigêmeo/química
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação/efeitos dos fármacos
Isótopos de Carbono
Relação Dose-Resposta a Droga
Camundongos
Camundongos Endogâmicos
Estrutura Molecular
Tomografia por Emissão de Pósitrons
Pirazinas/síntese química
Pirazinas/química
Piridinas/síntese química
Piridinas/química
Traçadores Radioativos
Relação Estrutura-Atividade
Canais de Cátion TRPV/biossíntese
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide); 0 (Pyrazines); 0 (Pyridines); 0 (Radioactive Tracers); 0 (TRPV Cation Channels); 0 (TRPV1 receptor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


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[PMID]:28864607
[Au] Autor:Kopka K; Benesová M; Barinka C; Haberkorn U; Babich J
[Ad] Endereço:Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, Heidelberg, Germany k.kopka@dkfz.de.
[Ti] Título:Glu-Ureido-Based Inhibitors of Prostate-Specific Membrane Antigen: Lessons Learned During the Development of a Novel Class of Low-Molecular-Weight Theranostic Radiotracers.
[So] Source:J Nucl Med;58(Suppl 2):17S-26S, 2017 Sep.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years, several radioligands targeting prostate-specific membrane antigen (PSMA) have been clinically introduced as a new class of theranostic radiopharmaceuticals for the treatment of prostate cancer (PC). In the second decade of the 21 century, a new era in nuclear medicine was initiated by the clinical introduction of small-molecule PSMA inhibitor radioligands, 40 y after the clinical introduction of F-FDG. Because of the high incidence and mortality of PC, the new PSMA radioligands have already had a remarkable impact on the clinical management of PC. For the continuing clinical development and long-term success of theranostic agents, designing modern prospective clinical trials in theranostic nuclear medicine is essential. First-in-human studies with PSMA radioligands derived from small-molecule PSMA inhibitors showed highly sensitive imaging of PSMA-positive PC by means of PET and SPECT as well as a dramatic response of metastatic castration-resistant PC after PSMA radioligand therapy. This tremendous success logically led to the initiation of prospective clinical trials with several PSMA radioligands. Meanwhile, MIP-1404, PSMA-11, 2-(3-{1-carboxy-5-[(6-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (DCFPyL), PSMA-617, PSMA-1007, and others have entered or will enter prospective clinical trials soon in several countries. The significance becomes apparent by, for example, the considerable increase in the number of publications about PSMA-targeted PET imaging from 2013 to 2016 (e.g., a search of the Web of Science for "PSMA" AND "PET" found only 19 publications in 2013 but 218 in 2016). Closer examination of the initial success of PC treatment with PSMA inhibitor radiotracers leads to several questions from the basic research perspective as well as from the perspective of clinical demands: What lessons have been learned regarding the design of PSMA radioligands that have already been developed? Has an acceptable compromise between optimal PSMA radioligand design and a broad range of clinical demands been reached? Can the lessons learned from multiple successes within the PSMA experience be transferred to further theranostic approaches?
[Mh] Termos MeSH primário: Diagnóstico
Descoberta de Drogas/métodos
Glutamato Carboxipeptidase II/antagonistas & inibidores
Ureia/química
Ureia/farmacologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Superfície
Seres Humanos
Peso Molecular
Traçadores Radioativos
Ureia/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antigens, Surface); 0 (Radioactive Tracers); 8W8T17847W (Urea); EC 3.4.17.21 (Glutamate Carboxypeptidase II); EC 3.4.17.21 (glutamate carboxypeptidase II, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.186775


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[PMID]:28490473
[Au] Autor:Gowrishankar G; Hardy J; Wardak M; Namavari M; Reeves RE; Neofytou E; Srinivasan A; Wu JC; Contag CH; Gambhir SS
[Ad] Endereço:Department of Radiology, Stanford University School of Medicine, Stanford, California.
[Ti] Título:Specific Imaging of Bacterial Infection Using 6″- F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria.
[So] Source:J Nucl Med;58(10):1679-1684, 2017 Oct.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:6″- F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like F-FDG has been used to image and localize most cancers. However, unlike F-FDG, 6″- F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. 6″- F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. 6″- F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″- F-fluoromaltotriose was also able to detect in a clinically relevant mouse model of wound infection. The utility of 6″- F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. 6″- F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.
[Mh] Termos MeSH primário: Infecções Bacterianas/diagnóstico por imagem
Infecções Bacterianas/metabolismo
Proteínas de Membrana Transportadoras/metabolismo
Polissacarídeos/metabolismo
Tomografia por Emissão de Pósitrons/métodos
Trissacarídeos
[Mh] Termos MeSH secundário: Animais
Transporte Biológico
Camundongos
Camundongos Nus
Traçadores Radioativos
Infecção dos Ferimentos/diagnóstico por imagem
Infecção dos Ferimentos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (6''-fluoromaltotriose); 0 (Membrane Transport Proteins); 0 (Polysaccharides); 0 (Radioactive Tracers); 0 (Trisaccharides); 639K0T34IK (maltotriose); 7CVR7L4A2D (maltodextrin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.117.191452


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[PMID]:28486208
[Au] Autor:Ahamed M; Attili B; van Veghel D; Ooms M; Berben P; Celen S; Koole M; Declercq L; Savinainen JR; Laitinen JT; Verbruggen A; Bormans G
[Ad] Endereço:Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg O&N2, Herestraat 49 Box 821, BE-3000 Leuven, Belgium.
[Ti] Título:Synthesis and preclinical evaluation of [ C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL).
[So] Source:Eur J Med Chem;136:104-113, 2017 Aug 18.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:MAGL is a potential therapeutic target for oncological and psychiatric diseases. Our objective was to develop a PET tracer for in vivo quantification of MAGL. We report [ C]MA-PB-1 as an irreversible MAGL inhibitor PET tracer. The in vitro inhibitory activity, ex vivo distribution, brain kinetics and specificity of [ C]MA-PB-1 binding were studied. Ex vivo biodistribution and microPET showed good brain uptake which could be blocked by pretreatment with both MA-PB-1 and a structurally non-related MAGL inhibitor MJN110. These initial results suggest that [ C]MA-PB-1 is a suitable tracer for in vivo imaging of MAGL.
[Mh] Termos MeSH primário: Compostos de Benzil/farmacologia
Encéfalo/enzimologia
Inibidores Enzimáticos/farmacologia
Monoacilglicerol Lipases/antagonistas & inibidores
Piperazinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Compostos de Benzil/síntese química
Compostos de Benzil/química
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Feminino
Macaca mulatta
Camundongos
Estrutura Molecular
Monoacilglicerol Lipases/metabolismo
Piperazinas/síntese química
Piperazinas/química
Tomografia por Emissão de Pósitrons
Traçadores Radioativos
Ratos
Ratos Wistar
Relação Estrutura-Atividade
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (((11)C)MA-PB-1); 0 (Benzyl Compounds); 0 (Enzyme Inhibitors); 0 (Piperazines); 0 (Radioactive Tracers); EC 3.1.1.23 (Monoacylglycerol Lipases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE


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[PMID]:28476531
[Au] Autor:Godin S; Bouzas-Ramos D; Fontagné-Dicharry S; Bouyssière B; Bueno M
[Ad] Endereço:CNRS/Univ. Pau & Pays de l'Adour, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux, LCABIE, UMR 5254, 64053 Pau, France. Electronic address: simon.godin@univ-pau.fr.
[Ti] Título:Deproteinization assessment using isotopically enriched compounds to trace the coprecipitation of low-molecular-weight selenium species with proteins.
[So] Source:Anal Biochem;530:9-16, 2017 Aug 01.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies have shown that information related to the presence of low-molecular-weight metabolites is frequently lost after deproteinization of complex matrices, such as blood and plasma, during sample preparation. Therefore, the effect of several deproteinization reagents on low-molecular-weight selenium species has been compared by species-specific isotope labeling. Two isotopically enriched selenium tracers were used to mimic models of small inorganic anionic ( Se-selenite) and organic zwitterionic ( Se-selenomethionine) species. The results presented here show that the use of a methanol-acetonitrile-acetone (1:1:1 v/v/v) mixture provided approximately two times less tracer loss from plasma samples in comparison with the classic procedure using acetonitrile, which may not be optimal as it leads to important losses of low-molecular-weight selenium species. In addition, the possible interactions between selenium tracers and proteins were investigated, revealing that both coprecipitation phenomena and association with proteins were potentially responsible for selenite tracer losses during protein precipitation in blood samples. However, coprecipitation phenomena were found to be fully responsible for losses of both tracers observed in plasma samples and of the selenomethionine tracer in blood samples. This successfully applied strategy is anticipated to be useful for more extensive future studies in selenometabolomics.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/análise
Plasma/química
Traçadores Radioativos
Radioisótopos de Selênio/análise
Selênio/análise
Selenometionina/análise
[Mh] Termos MeSH secundário: Proteínas Sanguíneas/isolamento & purificação
Espectrometria de Massas
Peso Molecular
Selênio/química
Selênio/isolamento & purificação
Radioisótopos de Selênio/química
Radioisótopos de Selênio/isolamento & purificação
Selenometionina/química
Selenometionina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Radioactive Tracers); 0 (Selenium Radioisotopes); 964MRK2PEL (Selenomethionine); H6241UJ22B (Selenium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


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[PMID]:28360209
[Au] Autor:Toczek J; Ye Y; Gona K; Kim HY; Han J; Razavian M; Golestani R; Zhang J; Wu TL; Jung JJ; Sadeghi MM
[Ad] Endereço:Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut.
[Ti] Título:Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.
[So] Source:J Nucl Med;58(8):1318-1323, 2017 Aug.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Matrix metalloproteinases (MMPs) play a key role in abdominal aortic aneurysm (AAA) development. Accordingly, MMP-targeted imaging provides important information regarding vessel wall biology in the course of aneurysm development. Given the small size of the vessel wall and its proximity with blood, molecular imaging of aneurysm optimally requires highly sensitive tracers with rapid blood clearance. To this end, we developed a novel hydrosoluble zwitterionic MMP inhibitor, RYM, on the basis of which a pan-MMP tracer, RYM1, was designed. Here, we describe the development and preclinical evaluation of RYM1 in comparison with RP805, a commonly used pan-MMP tracer in murine models of aneurysm. The macrocyclic hydroxamate-based pan-MMP inhibitor coupled with 6-hydrazinonicotinamide, RYM1, was synthesized and labeled with Tc. Radiochemical stability of Tc-RYM1 was evaluated by radio-high-performance liquid chromatography analysis. Tracer blood kinetics and biodistribution were compared with Tc-RP805 in C57BL/6J mice ( = 10). Tc-RYM1 binding to aneurysm and specificity were evaluated by quantitative autoradiography in apolipoprotein E-deficient (apoE ) mice with CaCl -induced carotid aneurysm ( = 11). Angiotensin II-infused apoE ( = 16) mice were used for small-animal SPECT/CT imaging. Aortic tissue MMP activity and macrophage marker CD68 expression were assessed by zymography and reverse-transcription polymerase chain reaction. RYM1 showed nanomolar range inhibition constants for several MMPs. Tc-RYM1 was radiochemically stable in mouse blood for 5 h and demonstrated rapid renal clearance and lower blood levels in vivo compared with Tc-RP805. Tc-RYM1 binding to aneurysm and its specificity were shown by autoradiography in carotid aneurysm. Angiotensin II infusion in apoE mice for 4 wk resulted in AAA formation in 36% (4/11) of surviving animals. In vivo Tc-RYM1 small-animal SPECT/CT images showed higher uptake of the tracer in AAA than nondilated aortae. Finally, aortic uptake of Tc-RYM1 in vivo correlated with aortic MMP activity and CD68 expression. The newly developed pan-MMP inhibitor-based tracer Tc-RYM1 displays favorable pharmacokinetics for early vascular imaging and enables specific detection of inflammation and MMP activity in aneurysm.
[Mh] Termos MeSH primário: Aneurisma/diagnóstico por imagem
Aneurisma/metabolismo
Ácidos Hidroxâmicos/metabolismo
Compostos Macrocíclicos/metabolismo
Inibidores de Metaloproteinases de Matriz/metabolismo
Metaloproteinases da Matriz/metabolismo
Imagem Molecular/métodos
Niacina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Artérias Carótidas/diagnóstico por imagem
Desenho de Drogas
Estabilidade de Medicamentos
Regulação Enzimológica da Expressão Gênica
Ácidos Hidroxâmicos/química
Ácidos Hidroxâmicos/farmacocinética
Compostos Macrocíclicos/química
Compostos Macrocíclicos/farmacocinética
Inibidores de Metaloproteinases de Matriz/química
Inibidores de Metaloproteinases de Matriz/farmacocinética
Camundongos
Niacina/química
Niacina/metabolismo
Niacina/farmacocinética
Traçadores Radioativos
Radioquímica
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxamic Acids); 0 (Macrocyclic Compounds); 0 (Matrix Metalloproteinase Inhibitors); 0 (Radioactive Tracers); 2679MF687A (Niacin); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.188656


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[PMID]:28360205
[Au] Autor:Seith F; Schmidt H; Kunz J; Küstner T; Gatidis S; Nikolaou K; la Fougère C; Schwenzer N
[Ad] Endereço:Diagnostic and Interventional Radiology, Department of Radiology, Eberhard Karls University, Tuebingen, Germany.
[Ti] Título:Simulation of Tracer Dose Reduction in F-FDG PET/MRI: Effects on Oncologic Reading, Image Quality, and Artifacts.
[So] Source:J Nucl Med;58(10):1699-1705, 2017 Oct.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of our study was to evaluate the effect of stepwise-reduced doses on objective and subjective image parameters and on oncologic readings in whole-body F-FDG PET/MRI. We retrospectively simulated the stepwise reduction of F-FDG doses of 19 patients (mean age ± SD, 50.9 ± 11.7 y; mean body mass index ± SD, 22.8 ± 3.2 kg/m ) who received a whole-body PET/MRI examination from 3 to 0.5 MBq/kg of body weight (kgBW) in intervals of 0.25. Objective imaging parameters were assessed by measuring the SUV and coefficient of variation in different regions (aorta, liver, spleen, kidney, small bowel, lumbar vertebra, psoas muscle, urinary bladder) as well as the noise-equivalent counting rates in each bed position. Subjective image quality was evaluated with a masked reading of each simulated PET compared with the dose of 2 MBq/kgBW. Oncologic reading was performed first according to PERCIST in each dose and second by defining malignant lesions in doses of 2 MBq/kgBW and the maximum dose image (gold standard). The diagnostic confidence of each lesion was measured using a Likert scale. With decreasing doses, regions in the mid abdomen showed a stronger decrease of SUV and noise-equivalent counting rates than regions in the upper abdomen (SUV , -45% and -15% on average in the small bowel and the liver, respectively). The coefficient of variation showed a nonlinear increase, pronounced below 1.5 MBq/kgBW. Subjective image quality was stable over a range between 1.25 and 2.75 MBq/kgBW compared with 2 MBq/kgBW. However, large photopenic areas in the mid abdomen were observed in 2 patients. In the PERCIST reading, target lesions were above the liver threshold with a stable SUV in all cases down to 2 MBq/kgBW. Eighty-six of 90 lesions were identified correctly with a dose of 2 MBq/kgBW; Likert scores did not differ significantly. A reduction of doses in F-FDG PET/MRI might be possible down to 2 MBq/kgBW in oncologic whole-body examinations. The image quality in the mid abdomen seems to be more affected by lower doses than in the upper abdomen, and in single cases large photopenic areas can occur. Therefore, we do not recommend reducing doses below 3 MBq/kgBW in adults at this time.
[Mh] Termos MeSH primário: Artefatos
Fluordesoxiglucose F18
Imagem por Ressonância Magnética/métodos
Imagem Multimodal/métodos
Neoplasias/diagnóstico por imagem
Tomografia por Emissão de Pósitrons/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Dose de Radiação
Traçadores Radioativos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radioactive Tracers); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.184440


  9 / 1593 MEDLINE  
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[PMID]:28358340
[Au] Autor:Mou T; Zhang X
[Ad] Endereço:Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. mtt207@163.com.
[Ti] Título:Research Progress on F-Labeled Agents for Imaging of Myocardial Perfusion with Positron Emission Tomography.
[So] Source:Molecules;22(4), 2017 Mar 30.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Coronary artery disease (CAD) is the leading cause of death in the world. Myocardial perfusion imaging (MPI) plays a significant role in non-invasive diagnosis and prognosis of CAD. However, neither single-photon emission computed tomography nor positron emission tomography clinical MPI agents can absolutely satisfy the demands of clinical practice. In the past decades, tremendous developments happened in the field of F-labeled MPI tracers. This review summarizes the current state of F-labeled MPI tracers, basic research data of those tracers, and the future direction of MPI tracer research.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/diagnóstico por imagem
Radioisótopos de Flúor/metabolismo
Imagem de Perfusão do Miocárdio/métodos
Tomografia por Emissão de Pósitrons/métodos
Compostos Radiofarmacêuticos/metabolismo
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Doença da Artéria Coronariana/metabolismo
Seres Humanos
Traçadores Radioativos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Fluorine Radioisotopes); 0 (Radioactive Tracers); 0 (Radiopharmaceuticals)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:28342743
[Au] Autor:Zajac M; Dolowy K
[Ad] Endereço:Department of Biophysics, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
[Ti] Título:Measurement of ion fluxes across epithelia.
[So] Source:Prog Biophys Mol Biol;127:1-11, 2017 Aug.
[Is] ISSN:1873-1732
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Epithelial tissues line all wet surfaces of vertebrate bodies. Their major function is directional transport of ions and water. Cells forming an epithelial layer are bound together by a tight junction that forms a barrier to ion flux. Ions and water are transported via specialized molecules. The presence of a defect in a single ion channel molecule leads to cystic fibrosis - the most common, fatal, human genetic disease. The paper describes ion transport data obtained by means of different experimental techniques. Special attention is given to radiochemical tracers, transepithelial resistance determination, open circuit potential and short circuit current measurements, the nasal potential difference in healthy and cystic fibrosis patients, the use of ion selective electrodes, and electrochemical mapping of the cell membrane surface. The effect of different activators and blockers of ion transport molecules on measured parameters are also discussed.
[Mh] Termos MeSH primário: Epitélio/metabolismo
[Mh] Termos MeSH secundário: Animais
Transporte Biológico
Fibrose Cística/metabolismo
Fibrose Cística/patologia
Seres Humanos
Íons/metabolismo
Microscopia Eletroquímica de Varredura
Traçadores Radioativos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ions); 0 (Radioactive Tracers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE



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