Base de dados : MEDLINE
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[PMID]:28452419
[Au] Autor:Joshi S; Rajasekaran K; Williamson J; Kapur J
[Ad] Endereço:Department of Neurology, University of Virginia, Charlottesville, Virginia, U.S.A.
[Ti] Título:Neurosteroid-sensitive δ-GABA receptors: A role in epileptogenesis?
[So] Source:Epilepsia;58(3):494-504, 2017 03.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We determined the role of the neurosteroid-sensitive δ subunit-containing γ-aminobutyric acid A receptors (δ-GABARs) in epileptogenesis. METHODS: Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video-electroencephalography (EEG) monitoring. Finasteride was administered to inhibit neurosteroid synthesis. The total and surface protein expression of hippocampal δ, α4, and γ2 GABAR subunits was studied using biotinylation assays and Western blotting. Neurosteroid potentiation of the tonic currents of dentate granule cells (DGCs) was measured by whole-cell patch-clamp technique. Finally, the effects of inhibiting N-methyl-d-aspartate receptors (NMDARs) during SE on the long-term plasticity of δ-GABARs, neurosteroid-induced modulation of tonic current, and epileptogenesis were studied. RESULTS: The inhibition of neurosteroid synthesis 4 days after SE triggered acute seizures and accelerated the onset of chronic recurrent spontaneous seizures (epilepsy). The down-regulation of neurosteroid-sensitive δ-GABARs occurred prior to the onset of epilepsy, whereas an increased expression of the γ2-GABAR subunits occurred after seizure onset. MK801 blockade of NMDARs during SE preserved the expression of neurosteroid-sensitive δ-GABARs. NMDAR blockade during SE also prevented the onset of spontaneous seizures. SIGNIFICANCE: Changes in neurosteroid-sensitive δ-GABAR expression correlated temporally with epileptogenesis. These findings raise the possibility that δ-GABAR plasticity may play a role in epileptogenesis.
[Mh] Termos MeSH primário: Epilepsia do Lobo Temporal/fisiopatologia
Neurotransmissores/fisiologia
Receptores de GABA-A/fisiologia
Estado Epiléptico/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Giro Denteado/fisiopatologia
Modelos Animais de Doenças
Maleato de Dizocilpina/farmacologia
Regulação para Baixo/efeitos dos fármacos
Regulação para Baixo/fisiologia
Eletroencefalografia/efeitos dos fármacos
Feminino
Finasterida/farmacologia
Hipocampo/fisiopatologia
Compostos de Lítio
Masculino
Plasticidade Neuronal/efeitos dos fármacos
Plasticidade Neuronal/fisiologia
Neurônios/efeitos dos fármacos
Neurônios/fisiologia
Neurotransmissores/antagonistas & inibidores
Técnicas de Patch-Clamp
Pilocarpina
Ratos
Ratos Sprague-Dawley
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lithium Compounds); 0 (Neurotransmitter Agents); 0 (Receptors, GABA-A); 0 (Receptors, N-Methyl-D-Aspartate); 01MI4Q9DI3 (Pilocarpine); 57GNO57U7G (Finasteride); 6LR8C1B66Q (Dizocilpine Maleate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13660


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[PMID]:27770296
[Au] Autor:Girardi P; Brugnoli R; Manfredi G; Sani G
[Ad] Endereço:Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy. paolo.girardi@uniroma1.it.
[Ti] Título:Lithium in Bipolar Disorder: Optimizing Therapy Using Prolonged-Release Formulations.
[So] Source:Drugs R D;16(4):293-302, 2016 Dec.
[Is] ISSN:1179-6901
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Lithium has been a gold standard in the treatment of bipolar disorder (BD) for several decades. Despite a general reduction in the use of lithium over the past several years, it is effective in the management of both manic and depressive episodes in BD and continues to be recommended as a first-line mood stabilizer. This review provides an overview of the pharmacology of lithium and highlights its clinical profile in the management of BD, focusing on the potential advantages of prolonged-release (PR) versus immediate-release (IR) formulations of lithium. A literature search using PubMed was performed to identify articles describing IR and PR lithium in BD using specific search terms like 'lithium', 'prolonged-release', 'sustained-release', 'extended-release', 'bipolar disorder', 'adherence' and 'compliance'. Relevant pharmacodynamic and pharmacokinetic data were also included. Several clinical trials suggested that lithium is effective in the treatment of acute mania and prophylaxis of BD and reduces the risk of suicide in patients with BD; it may also be used in combination with other drugs in the treatment of bipolar depression. Treatment with lithium must be monitored to avoid lithium-associated toxicity. The prolonged PR formulation of lithium has several advantages including consistent serum lithium concentrations, fewer adverse events and improved adherence to therapy. Although direct comparative studies between PR and IR formulations of lithium are primarily limited to pharmacokinetic studies, PR formulation of lithium provides potential advantages over IR formulation and can be effectively used in the management of BD with lesser adverse events.
[Mh] Termos MeSH primário: Antimaníacos/uso terapêutico
Transtorno Bipolar/tratamento farmacológico
Composição de Medicamentos
Compostos de Lítio/uso terapêutico
[Mh] Termos MeSH secundário: Antimaníacos/administração & dosagem
Preparações de Ação Retardada
Seres Humanos
Compostos de Lítio/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Delayed-Action Preparations); 0 (Lithium Compounds)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29232311
[Au] Autor:Mooney JJ; Brady RO
[Ad] Endereço:From the Department of Psychiatry, Beth Israel Deaconess Medical Center; and Harvard Medical School, Boston, MA.
[Ti] Título:Lithium + Colchicine: A Potential Strategy to Reduce Pro-inflammatory Effects of Lithium Treatment.
[So] Source:J Clin Psychopharmacol;38(1):80-85, 2018 Feb.
[Is] ISSN:1533-712X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Rosenblat and McIntyre (Acta Psychiatr Scand. 2015;132: 180-191) propose that immune disorders are important mediators between bipolar disorders and medical comorbidities. Rosenblat et al (Bipolar Disord. 2016;18:89-101) present a meta-analysis showing that adjunctive anti-inflammatory agents could evoke moderate antidepressant responses in bipolar disorders. We propose using the anti-inflammatory drug colchicine to improve the long-term safety and efficacy of lithium treatment for bipolar disorders. METHODS: This report is based on searches of the PubMed and Web of Science databases. RESULTS: Bipolar disorders are associated with significant medical comorbidities such as hypertension, overweight/obesity, diabetes mellitus, metabolic syndrome, and arteriosclerosis, accompanied by enhanced release of pro-inflammatory markers during changes in mood state. During lithium therapy, granulocyte-colony stimulating factor, CD34+ hematopoietic stem/progenitor cells, and neutrophil elastase enter the circulation with activated neutrophils to promote the extravascular migration of activated neutrophils and enhance tissue inflammation. Concurrent treatment with lithium and low-dose colchicine could facilitate the responsiveness of bipolar patients to lithium by reducing leukocyte tissue emigration, the release of neutrophil elastase, and the release of leukocyte pro-inflammatory cytokines such as IL-1ß that are regulated by the NLRP3 inflammasome assembly complex. CONCLUSIONS: Concurrent therapy with lithium and low-dose colchicine could reduce complications involving leukocyte-mediated inflammatory states in bipolar patients and promote patient acceptance and responsiveness to lithium therapy.
[Mh] Termos MeSH primário: Colchicina/administração & dosagem
Inflamação/prevenção & controle
Compostos de Lítio/efeitos adversos
[Mh] Termos MeSH secundário: Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/farmacologia
Transtorno Bipolar/complicações
Transtorno Bipolar/tratamento farmacológico
Colchicina/farmacologia
Citocinas
Relação Dose-Resposta a Droga
Seres Humanos
Inflamação/induzido quimicamente
Compostos de Lítio/administração & dosagem
Aceitação pelo Paciente de Cuidados de Saúde
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Lithium Compounds); SML2Y3J35T (Colchicine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1097/JCP.0000000000000830


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[PMID]:29228982
[Au] Autor:Rask O; Suneson K; Holmström E; Bäckström B; Johansson BA
[Ad] Endereço:Department of Clinical Sciences, Division of Pediatrics, Lund University, Lund, Sweden. olof.rask@med.lu.se.
[Ti] Título:Electroconvulsive therapy for manic state with mixed and psychotic features in a teenager with bipolar disorder and comorbid episodic obsessive-compulsive disorder: a case report.
[So] Source:J Med Case Rep;11(1):345, 2017 Dec 12.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Comorbidity of bipolar disorder and obsessive-compulsive disorder is common in adolescence. Obsessive-compulsive disorder symptoms may be episodic and secondary to alterations in mood, and display specific features. Management of pediatric bipolar disorder-obsessive-compulsive disorder is challenging, as pharmacotherapy of obsessive-compulsive disorder may induce or exacerbate manic episodes and there is limited evidence of treatment efficacy. Electroconvulsive therapy is sparsely used in children and adolescents, but is documented to be a safe and efficacious intervention in adults with bipolar disorder. In view of the severity of symptoms in juvenile mania, studies on treatment strategies are warranted. We report a case of an adolescent with bipolar disorder-obsessive-compulsive disorder who was successfully treated with electroconvulsive therapy during an episode of severe mania. CASE PRESENTATION: A 16-year-old girl of Middle East origin first presented to us with depressed mood, irritability, and increased obsessive-compulsive disorder symptoms, which were initially interpreted in the context of acute stress secondary to migration. She had been diagnosed with bipolar disorder and obsessive-compulsive disorder in her previous home country, but had difficulties in accounting for earlier psychiatric history. During hospitalization her mood switched to a manic state with mixed and psychotic features, at times showing aggression toward others. Interruption in her lithium treatment for a short period and possibly the introduction of an atypical antipsychotic could in part have been triggering factors. After 8 weeks of in-patient care and psychotropic drug trials, electroconvulsive therapy was initiated and administered every second or third day for 4 weeks, with marked positive response. No apparent side effects were reported. CONCLUSIONS: This case demonstrates the need for a detailed medical history, taking special note of periodicity and character of obsessive-compulsive disorder symptoms, in adolescents with mood disorders. When treating culturally diverse patients, extra consideration should be taken. Special concerns in the pharmacological treatment to avoid the patient's condition from worsening must be addressed, including giving priority to mood stabilization before obsessive-compulsive disorder symptoms. There are potential benefits in considering electroconvulsive therapy in young patients with severe mania where first-line treatment options have failed.
[Mh] Termos MeSH primário: Transtorno Bipolar/terapia
Eletroconvulsoterapia/métodos
Transtorno Obsessivo-Compulsivo/terapia
Refugiados
[Mh] Termos MeSH secundário: Adolescente
Antimaníacos/uso terapêutico
Antipsicóticos/uso terapêutico
Transtorno Bipolar/epidemiologia
Transtorno Bipolar/psicologia
Comorbidade
Feminino
Haloperidol/uso terapêutico
Seres Humanos
Compostos de Lítio/uso terapêutico
Oriente Médio/etnologia
Transtorno Obsessivo-Compulsivo/epidemiologia
Transtorno Obsessivo-Compulsivo/psicologia
Suécia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Antipsychotic Agents); 0 (Lithium Compounds); J6292F8L3D (Haloperidol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1508-8


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[PMID]:28458438
[Au] Autor:Maddala RNM; Ashwal AJ; Rao MS; Padmakumar R
[Ad] Endereço:Department of Medicine, Manipal University, Manipal, Udupi, Karnataka, India.
[Ti] Título:Chronic lithium intoxication: Varying electrocardiogram manifestations.
[So] Source:Indian J Pharmacol;49(1):127-129, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Lithium is a commonly used drug in psychiatric practice. It is used in the treatment of depression and bipolar disorder. It has a narrow therapeutic index with documented adverse effects even near therapeutic levels. It has myriad of manifestations at toxic levels. The cardiovascular effects range from relatively benign ST-T wave changes to fatal arrhythmias. We describe a case of lithium toxicity which presented as a junctional rhythm and later showed a variety of manifestations such as complete heart block, atrial fibrillation, sinus bradycardia, and finally reverted to sinus rhythm at par with serum lithium levels.
[Mh] Termos MeSH primário: Antimaníacos/efeitos adversos
Arritmias Cardíacas/induzido quimicamente
Compostos de Lítio/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Antimaníacos/administração & dosagem
Antimaníacos/sangue
Arritmias Cardíacas/fisiopatologia
Fibrilação Atrial/induzido quimicamente
Transtorno Bipolar/tratamento farmacológico
Bradicardia/induzido quimicamente
Eletrocardiografia
Feminino
Bloqueio Cardíaco/induzido quimicamente
Seres Humanos
Compostos de Lítio/administração & dosagem
Compostos de Lítio/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Lithium Compounds)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/ijp.IJP_204_16


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[PMID]:28965429
[Au] Autor:Richardson T; Macaluso M
[Ad] Endereço:a Department of Psychiatry and Behavioral Sciences , Kansas University School of Medicine-Wichita , Wichita , KS , USA.
[Ti] Título:Clinically relevant treatment considerations regarding lithium use in bipolar disorder.
[So] Source:Expert Opin Drug Metab Toxicol;13(11):1105-1113, 2017 Nov.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The goal of this paper is to provide a practical, clinically oriented review of lithium, a salt widely used to treat mania since the 1870s and formally approved as a mood stabilizer in 1970. Although lithium is still considered a first-line treatment for bipolar mania in most practice guidelines, its use may be overshadowed by newer psychotropic medications. Areas covered: This paper addresses the historical use of lithium, modern indications for its use, guidelines for prescribing and monitoring continued lithium use, drug-drug interactions, and pharmacodynamics/pharmacokinetic properties. The paper also reviews the unique properties of lithium and their potential clinical importance. Expert opinion: While the use of lithium does involve some unique risks to the patient, it may also has some unique advantages in certain patient populations. Two major findings that make lithium unique are its potential neuroprotective benefits and decreased risk of suicide in patients with mood disorders.
[Mh] Termos MeSH primário: Antimaníacos/uso terapêutico
Transtorno Bipolar/tratamento farmacológico
Compostos de Lítio/uso terapêutico
[Mh] Termos MeSH secundário: Antimaníacos/administração & dosagem
Antimaníacos/efeitos adversos
Transtorno Bipolar/fisiopatologia
Interações Medicamentosas
Monitoramento de Medicamentos/métodos
Seres Humanos
Compostos de Lítio/administração & dosagem
Compostos de Lítio/efeitos adversos
Guias de Prática Clínica como Assunto
Suicídio/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Lithium Compounds)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2017.1386653


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[PMID]:28817727
[Au] Autor:Steinbach G; Hockenbery DM; Huls G; Furlong T; Myerson D; Loeb KR; Fann JR; Castilla-Llorente C; McDonald GB; Martin PJ
[Ad] Endereço:Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
[Ti] Título:Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease.
[So] Source:PLoS One;12(8):e0183284, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Severe intestinal graft-vs-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT) causes mucosal ulceration and induces innate and adaptive immune responses that amplify and perpetuate GVHD and the associated barrier dysfunction. Pharmacological agents to target mucosal barrier dysfunction in GVHD are needed. We hypothesized that induction of Wnt signaling by lithium, an inhibitor of glycogen synthase kinase (GSK3), would potentiate intestinal crypt proliferation and mucosal repair and that inhibition of GSK3 in inflammatory cells would attenuate the deregulated inflammatory response to mucosal injury. We conducted an observational pilot study to provide data for the potential design of a randomized study of lithium. Twenty patients with steroid refractory intestinal GVHD meeting enrollment criteria were given oral lithium carbonate. GVHD was otherwise treated per current practice, including 2 mg/kg per day of prednisone equivalent. Seventeen patients had extensive mucosal denudation (extreme endoscopic grade 3) in the duodenum or colon. We observed that 8 of 12 patients (67%) had a complete remission (CR) of GVHD and survived more than 1 year (median 5 years) when lithium administration was started promptly within 3 days of endoscopic diagnosis of denuded mucosa. When lithium was started promptly and less than 7 days from salvage therapy for refractory GVHD, 8 of 10 patients (80%) had a CR and survived more than 1 year. In perspective, a review of 1447 consecutive adult HCT patients in the preceding 6 years at our cancer center showed 0% one-year survival in 27 patients with stage 3-4 intestinal GVHD and grade 3 endoscopic appearance in the duodenum or colon. Toxicities included fatigue, somnolence, confusion or blunted affect in 50% of the patients. The favorable outcomes in patients who received prompt lithium therapy appear to support the future conduct of a randomized study of lithium for management of severe GVHD with extensive mucosal injury. TRIAL REGISTRATION: ClinicalTrials.gov NCT00408681.
[Mh] Termos MeSH primário: Doença Enxerto-Hospedeiro/fisiopatologia
Mucosa Intestinal/efeitos dos fármacos
Compostos de Lítio/farmacologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Mucosa Intestinal/fisiopatologia
Compostos de Lítio/efeitos adversos
Masculino
Meia-Idade
Projetos Piloto
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Lithium Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183284


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[PMID]:28595491
[Au] Autor:Song J; Sjölander A; Joas E; Bergen SE; Runeson B; Larsson H; Landén M; Lichtenstein P
[Ad] Endereço:From the Department of Medical Epidemiology and Biostatistics and the Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm; the Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; the Stanley
[Ti] Título:Suicidal Behavior During Lithium and Valproate Treatment: A Within-Individual 8-Year Prospective Study of 50,000 Patients With Bipolar Disorder.
[So] Source:Am J Psychiatry;174(8):795-802, 2017 Aug 01.
[Is] ISSN:1535-7228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Conclusions regarding lithium's antisuicidal effect for bipolar disorder have been limited due to nonrepresentative subjects and potential confounding factors, including varying severity of illness. Findings regarding the effect of valproate, the most common alternative to lithium, are inconsistent for suicidal behavior. This study investigated the associations of these two drugs with the risk of suicide-related events, and possible differences between drugs, by using within-individual designs in a register-based longitudinal cohort. METHOD: Through linkage of multiple Swedish national registers, 51,535 individuals with bipolar disorder were followed from 2005 to 2013 for treatment with lithium and valproate. Stratified Cox regression was used to estimate the hazard ratios of suicide-related events during treated periods compared with untreated periods. For significant associations between medication and suicide-related events, the population attributable fraction was estimated to assess the public health impact for patients with bipolar disorder. RESULTS: During follow-up, 10,648 suicide-related events occurred. The incidence rate was significantly decreased by 14% during lithium treatment (hazard ratio 0.86, 95% confidence interval [CI] 0.78-0.95) but not during valproate treatment (hazard ratio 1.02, 95% CI 0.89-1.15). The difference in hazard ratios of suicide-related events between lithium and valproate was statistically significant. Estimates of the population attributable fraction suggested that 12% (95% CI 4%-20%) of suicide-related events could have been avoided if patients had taken lithium during the entire follow-up. CONCLUSIONS: The results suggest that lithium should be considered for patients with bipolar disorder with suspected suicidal intentions, although risk for suicide is only one of the considerations when providing clinical care.
[Mh] Termos MeSH primário: Antimaníacos/uso terapêutico
Transtorno Bipolar/tratamento farmacológico
Transtorno Bipolar/psicologia
Compostos de Lítio/uso terapêutico
Tentativa de Suicídio/prevenção & controle
Suicídio/prevenção & controle
Sulfatos/uso terapêutico
Ácido Valproico/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antimaníacos/efeitos adversos
Feminino
Seres Humanos
Armazenamento e Recuperação da Informação/estatística & dados numéricos
Compostos de Lítio/efeitos adversos
Estudos Longitudinais
Masculino
Meia-Idade
Modelos de Riscos Proporcionais
Sistema de Registros/estatística & dados numéricos
Risco
Suicídio/psicologia
Suicídio/estatística & dados numéricos
Tentativa de Suicídio/psicologia
Tentativa de Suicídio/estatística & dados numéricos
Sulfatos/efeitos adversos
Suécia
Ácido Valproico/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (Lithium Compounds); 0 (Sulfates); 614OI1Z5WI (Valproic Acid); 919XA137JK (lithium sulfate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1176/appi.ajp.2017.16050542


  9 / 2581 MEDLINE  
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[PMID]:28591541
[Au] Autor:Patorno E; Huybrechts KF; Bateman BT; Cohen JM; Desai RJ; Mogun H; Cohen LS; Hernandez-Diaz S
[Ad] Endereço:From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine (E.P., K.F.H., B.T.B., R.J.D., H.M.), and the Department of Anesthesiology, Perioperative and Pain Medicine (B.T.B.), Brigham and Women's Hospital and Harvard Medical School, the Department of Epidemiology, Harva
[Ti] Título:Lithium Use in Pregnancy and the Risk of Cardiac Malformations.
[So] Source:N Engl J Med;376(23):2245-2254, 2017 06 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There has been concern that exposure to lithium early in pregnancy may be associated with a marked increase in the risk of Ebstein's anomaly (a right ventricular outflow tract obstruction defect) in infants and overall congenital cardiac defects, but data are conflicting and limited. METHODS: We conducted a cohort study involving 1,325,563 pregnancies in women who were enrolled in Medicaid and who delivered a live-born infant between 2000 and 2010. We examined the risk of cardiac malformations among infants exposed to lithium during the first trimester as compared with unexposed infants and, in secondary analyses, with infants exposed to another commonly used mood stabilizer, lamotrigine. Risk ratios and 95% confidence intervals were estimated with control for psychiatric and medical conditions, medications, and other potential confounders. RESULTS: Cardiac malformations were present in 16 of the 663 infants exposed to lithium (2.41%), 15,251 of the 1,322,955 nonexposed infants (1.15%), and 27 of the 1945 infants exposed to lamotrigine (1.39%). The adjusted risk ratio for cardiac malformations among infants exposed to lithium as compared with unexposed infants was 1.65 (95% confidence interval [CI], 1.02 to 2.68). The risk ratio was 1.11 (95% CI, 0.46 to 2.64) for a daily dose of 600 mg or less, 1.60 (95% CI, 0.67 to 3.80) for 601 to 900 mg, and 3.22 (95% CI, 1.47 to 7.02) for more than 900 mg. The prevalence of right ventricular outflow tract obstruction defects was 0.60% among lithium-exposed infants versus 0.18% among unexposed infants (adjusted risk ratio, 2.66; 95% CI, 1.00 to 7.06). Results were similar when lamotrigine-exposed infants were used as the reference group. CONCLUSIONS: Maternal use of lithium during the first trimester was associated with an increased risk of cardiac malformations, including Ebstein's anomaly; the magnitude of this effect was smaller than had been previously postulated. (Funded by the National Institute of Mental Health.).
[Mh] Termos MeSH primário: Antidepressivos/efeitos adversos
Transtorno Bipolar/tratamento farmacológico
Cardiopatias Congênitas/induzido quimicamente
Compostos de Lítio/efeitos adversos
Complicações na Gravidez/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Anticonvulsivantes/efeitos adversos
Anticonvulsivantes/uso terapêutico
Antidepressivos/uso terapêutico
Antimaníacos/efeitos adversos
Antimaníacos/uso terapêutico
Estudos de Coortes
Feminino
Cardiopatias Congênitas/epidemiologia
Seres Humanos
Lactente
Recém-Nascido
Compostos de Lítio/uso terapêutico
Gravidez
Primeiro Trimestre da Gravidez
Prevalência
Triazinas/efeitos adversos
Triazinas/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Antidepressive Agents); 0 (Antimanic Agents); 0 (Lithium Compounds); 0 (Triazines); U3H27498KS (lamotrigine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1612222


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Fotocópia
[PMID]:28574390
[Au] Autor:Vadachkoria D; Vadachkoria O
[Ad] Endereço:UniDent - Dental Clinic, Training and Research center, Tbilisi, Georgia; Dr. Thomas Lehmann's Dental Clinic, Neumunster, Germany.
[Ti] Título:CLINICAL PROTOCOLS: PREPARATION, IMPRESSION AND BONDING OF ALL-CERAMIC GLASS-BASED DISILICATE LITHIUM CROWNS: REVIEW AND CASE REPORT.
[So] Source:Georgian Med News;(265):94-98, 2017 Apr.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:Using contemporary materials and techniques, nowadays we can offer the patients much needed restorations while achieving the desired aesthetics. The maxillary incisors are supremely important in the appearance of a smile. By establishing proper size, contours, vitality, translucency and relationship with the surrounding teeth and soft tissue, we can help create the smile of their dream. In modern dentistry, there are two major recent developments - the dentine bonding and stronger all-ceramic crown systems. Use of glass-based disilicate lithium ceramic crowns in combination with resin cements provides more desirable aesthetic solution than traditional porcelain-fused-to-metal (PFM) crowns. However, use of these materials is extremely technique sensitive. They require additional marginal precision of tooth preparation and bonding with resin cement. Consequently, protocols of tooth preparation and bonding are essential for long-term success. The presented article describes the preparation, impression and bonding guidelines aided by case presentation. According to the discussed protocols, dentists who take advantage of benefits of these contemporary materials and technologies will achieve more durable and reliable bonding with improved aesthetics.
[Mh] Termos MeSH primário: Coroas
Porcelana Dentária
Compostos de Lítio
Silicatos
[Mh] Termos MeSH secundário: Adulto
Protocolos Clínicos
Colagem Dentária
Técnica de Moldagem Odontológica
Restauração Dentária Permanente
Feminino
Seres Humanos
Preparo Prostodôntico do Dente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lithium Compounds); 0 (Silicates); 12001-21-7 (Dental Porcelain)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE



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