Base de dados : MEDLINE
Pesquisa : D01.524.490 [Categoria DeCS]
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[PMID]:29338217
[Au] Autor:Naseeruddin R; Sumathi V; Prasad TNVKV; Sudhakar P; Chandrika V; Ravindra Reddy B
[Ad] Endereço:Department of Agronomy, Sri Venkateswara Agricultural College, ‡Nanotechnology Lab, Institute of Frontier Technology, Regional Agricultural Research Station (RARS), §Crop Physiology, Sri Venkateswara Agricultural College, and ∥Department of Statistics and Mathematics, Sri Venkateswara Agricultural
[Ti] Título:Unprecedented Synergistic Effects of Nanoscale Nutrients on Growth, Productivity of Sweet Sorghum [Sorghum bicolor (L.) Moench], and Nutrient Biofortification.
[So] Source:J Agric Food Chem;66(5):1075-1084, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Evidence-based synergistic effects of nanoscale materials (size of <100 nm in at least one dimension) were scantly documented in agriculture at field scale. Herein, we report for the first time on effects of nanoscale zinc oxide (n-ZnO), calcium oxide (n-CaO), and magnesium oxide (n-MgO) on growth and productivity of sweet sorghum [Sorghum bicolor (L.) Moench]. A modified sol-gel method was used to prepare nanoscale materials under study. Characterization was performed using transmission and scanning electron microscopies, X-ray diffraction, and dynamic light scattering. Average sizes (25, 53.7, and 53.5 nm) and ζ potentials (-10.9, -28.2, and -16.2 mV) of n-ZnO, n-CaO, and n-MgO were measured, respectively. The significant grain yield (17.8 and 14.2%), cane yield (7.2 and 8.0%), juice yield (10 and 12%), and higher sucrose yield (21.8 and 20.9%) were recorded with the application of nanoscale materials in the years 2014 and 2015, respectively. Nutrient uptake was significant with foliar application of nanoscale nutrients.
[Mh] Termos MeSH primário: Biofortificação/métodos
Compostos de Cálcio/administração & dosagem
Óxido de Magnésio/administração & dosagem
Nanopartículas/administração & dosagem
Óxidos/administração & dosagem
Sorghum/crescimento & desenvolvimento
Óxido de Zinco/administração & dosagem
[Mh] Termos MeSH secundário: Agricultura/métodos
Compostos de Cálcio/metabolismo
Sinergismo Farmacológico
Óxido de Magnésio/metabolismo
Microscopia Eletrônica de Varredura
Óxidos/metabolismo
Tamanho da Partícula
Sorghum/efeitos dos fármacos
Óxido de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Oxides); 3A3U0GI71G (Magnesium Oxide); C7X2M0VVNH (lime); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04467


  2 / 1378 MEDLINE  
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[PMID]:28458356
[Au] Autor:Hayashi H; Suzuki A; Ohata K; Ishihara M; Kubota Y; Kobayashi R; Shibata Y; Nakamura H; Nakamura N; Kitagawa J; Tsurumi H; Shimizu M; Itoh Y
[Ad] Endereço:Department of Pharmacy, Gifu University Hospital.
[Ti] Título:Control of Constipation in Patients Receiving CHOP or CHOP-Like Chemotherapy Regimens for Non-Hodgkin's Lymphoma.
[So] Source:Biol Pharm Bull;40(5):698-702, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Management of constipation in patients receiving cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) or CHOP-like chemotherapy regimens is important for prevention of paralytic ileus. We reported earlier that the laxative action of magnesium oxide is reversed by the concomitant use of antacids in cancer patients receiving opioid analgesics. Here, we assessed the prevalence of prophylactic laxative medication for the control of constipation in patients receiving CHOP or CHOP-like regimens for non-Hodgkin's lymphoma. Data obtained from 211 eligible patients were retrospectively analyzed. Almost all patients (99%) received anti-ulcer agents such as proton pump inhibitors and H receptor antagonists for the prophylaxis of gastric disorders associated with prednisolone. Prophylactic laxatives were prescribed in 86 patients (40.8%), in which magnesium oxide was used most predominantly (88.4%). However, magnesium oxide at doses of ≦2000 mg/d was not effective for prevention of constipation, although the compound totally inhibited the incidence of constipation at doses higher than 2000 mg/d. Therefore, it is important to avoid negative drug interaction between magnesium oxide and antacids in patients receiving CHOP chemotherapy.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Constipação Intestinal/induzido quimicamente
Constipação Intestinal/prevenção & controle
Laxantes/uso terapêutico
Linfoma não Hodgkin/complicações
Linfoma não Hodgkin/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Antiácidos/uso terapêutico
Constipação Intestinal/epidemiologia
Ciclofosfamida/efeitos adversos
Doxorrubicina/efeitos adversos
Feminino
Seres Humanos
Incidência
Óxido de Magnésio/uso terapêutico
Masculino
Meia-Idade
Prednisona/efeitos adversos
Estudos Retrospectivos
Vincristina/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antacids); 0 (Laxatives); 3A3U0GI71G (Magnesium Oxide); 5J49Q6B70F (Vincristine); 80168379AG (Doxorubicin); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-01001


  3 / 1378 MEDLINE  
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[PMID]:28464615
[Au] Autor:Nygren H; Bigdeli N; Ilver L; Malmberg P
[Ad] Endereço:Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, POB 440, 40530 Gothenburg, Sweden.
[Ti] Título:Mg-corrosion, hydroxyapatite, and bone healing.
[So] Source:Biointerphases;12(2):02C407, 2017 05 02.
[Is] ISSN:1559-4106
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The different capacities of magnesium in the metallic form (Mg-metal) and magnesium oxide (MgO) to stimulate bone healing are possible clues in the search for products that may promote bone healing. Since both Mg-metal and MgO can be assumed to release comparable amounts of Mg ions during their reactions in the tissue where they have been implanted, it is of some importance to follow this process and analyze the resulting mineral formation in the tissue at the implantation site. Implants of MgO were inserted into rat tibia, and the bone healing was compared with sham-operated controls. Samples were taken after 1 week of healing and analyzed by histology, environmental scanning electron microscopy equipped with an energy dispersive x-ray spectroscopy analyzer, and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Callus bone was seen in sham-operated controls after 1 week of healing. Implantation of MgO impaired the callus bone formation by replacing bone with apparently mineralized areas, lacking osteocytes and were denoted, amorphous bodies. Elemental analysis showed increased levels of Ca (7.1%), P (3.7%), and Mg (0.2%) in the bone marrow of MgO-treated animals versus sham-operated controls Ca (2.4%), P (2.3%), and Mg (0.1%). The Ca content of the cortical bone was also significantly increased (Ca, 29% increase) in MgO-treated animals compared to sham-operated controls. The Ca content of the cortical bone of sham-operated animals was also significantly (p < 0.05) higher than the corresponding value of untreated animals, which means that the surgical trauma induces an altered composition of the bone mineral. The Ca/P ratio was 1.26-1.68, which is compatible with that of mineralized bone with different contents of organic materials. Analysis of bone sections using ToF-SIMS showed the presence of hydroxyapatite (HA) and MgCO in the bone marrow and in cortical bone. Analysis using x-ray photoelectron spectroscopy of Mg, MgO, and MgCO after incubation with cell culture medium (DMEM), in vitro, showed binding of CaPO at the Mg and MgO samples. The Ca/P ratio was 0.8, indicating a higher P content than that expected for HA. Exposure of human embryonic stem cells to Mg species preincubated in DMEM resulted in HA production by the cells. Thus, two sources of CaPO in the bone marrow of MgO-treated bone were defined, catalytic formation on Mg-species and synthesis from activated stem-cells. The presented data suggest that bone healing near Mg implants is congruent with the fracture healing of bone, boosted by high HA levels in the bone marrow. In this context, the different capacities of Mg-metal and MgO to catalyse the formation of HA can be important clues to their different bone promoting effects.
[Mh] Termos MeSH primário: Calo Ósseo/metabolismo
Osso Cortical/lesões
Osso Cortical/metabolismo
Durapatita/farmacologia
Consolidação da Fratura/efeitos dos fármacos
Óxido de Magnésio/farmacologia
[Mh] Termos MeSH secundário: Animais
Calo Ósseo/patologia
Linhagem Celular
Corrosão
Osso Cortical/patologia
Células-Tronco Embrionárias Humanas
Seres Humanos
Magnésio/farmacologia
Masculino
Teste de Materiais
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3A3U0GI71G (Magnesium Oxide); 91D9GV0Z28 (Durapatite); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1116/1.4982601


  4 / 1378 MEDLINE  
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[PMID]:28690302
[Au] Autor:Tahara S; Yamamoto S; Yamajima Y; Miyakawa H; Uematsu Y; Monma K
[Ad] Endereço:Tokyo Metropolitan Institute of Public Health.
[Ti] Título:A Rapid Dialysis Method for Analysis of Artificial Sweeteners in Foods (2nd Report).
[So] Source:Shokuhin Eiseigaku Zasshi;58(3):124-131, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Following the previous report, a rapid dialysis method was developed for the extraction and purification of four artificial sweeteners, namely, sodium saccharide (Sa), acesulfame potassium (AK), aspartame (APM), and dulcin (Du), which are present in various foods. The method was evaluated by the addition of 0.02 g/kg of these sweeteners to a cookie sample, in the same manner as in the previous report. Revisions from the previous method were: reduction of the total dialysis volume from 200 to 100 mL, change of tube length from 55 to 50 cm, change of dialysate from 0.01 mol/L hydrochloric aqueous solution containing 10% sodium chloride to 30% methanol solution, and change of dialysis conditions from ambient temperature with occasional shaking to 50℃ with shaking at 160 rpm. As a result of these revisions, the recovery reached 99.3-103.8% with one hour dialysis. The obtained recovery yields were comparable to the recovery yields in the previous method with four hour dialysis.
[Mh] Termos MeSH primário: Aspartame/análise
Aspartame/isolamento & purificação
Diálise/métodos
Análise de Alimentos/métodos
Compostos de Fenilureia/análise
Compostos de Fenilureia/isolamento & purificação
Sacarina/análise
Sacarina/isolamento & purificação
Edulcorantes/análise
Edulcorantes/isolamento & purificação
Tiazinas/análise
Tiazinas/isolamento & purificação
[Mh] Termos MeSH secundário: Carbonato de Cálcio
Cromatografia Líquida de Alta Pressão
Citratos
Soluções para Diálise
Combinação de Medicamentos
Temperatura Alta
Ácido Clorídrico
Óxido de Magnésio
Metanol
Cloreto de Sódio
Fatores de Tempo
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Dialysis Solutions); 0 (Drug Combinations); 0 (Phenylurea Compounds); 0 (Suby's G solution); 0 (Sweetening Agents); 0 (Thiazines); 059QF0KO0R (Water); 3A3U0GI71G (Magnesium Oxide); 451W47IQ8X (Sodium Chloride); 8U78KF577Z (dulcin); FST467XS7D (Saccharin); H0G9379FGK (Calcium Carbonate); MA3UYZ6K1H (acetosulfame); QTT17582CB (Hydrochloric Acid); Y4S76JWI15 (Methanol); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.124


  5 / 1378 MEDLINE  
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[PMID]:28682544
[Au] Autor:Guoxin H; Ying Y; Yuemei J; Wenjing X
[Ad] Endereço:Fuzhou Medical College, Nanchang University, Fuzhou 344000, China.
[Ti] Título:[Study on friction and wear properties of dental zirconia ceramics processed by microwave and conventional sintering methods].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;35(2):150-154, 2017 Apr 01.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: This study evaluated the wear of an antagonist and friction and wear properties of dental zirconia ceramic that was subjected to microwave and conventional sintering methods. METHODS: Ten specimens were fabricated from Lava brand zirconia and randomly assigned to microwave and conventional sintering groups. A profile tester for surface roughness was used to measure roughness of the specimens. Wear test was performed, and steatite ceramic was used as antagonist. Friction coefficient curves were recorded, and wear volume were calculated. Finally, optical microscope was used to observe the surface morphology of zirconia and steatite ceramics. Field emission scanning electron microscopy was used to observe the microstructure of zirconia. RESULTS: Wear volumes of microwave and conventionally sintered zirconia were (6.940±1.382)×10⁻², (7.952±1.815) ×10⁻² mm³, respectively. Moreover, wear volumes of antagonist after sintering by the considered methods were (14.189±4.745)×10⁻², (15.813±3.481)×10⁻² mm³, correspondingly. Statistically significant difference was not observed in the wear resistance of zirconia and wear volume of steatite ceramic upon exposure to two kinds of sintering methods. Optical microscopy showed that ploughed surfaces were apparent in zirconia. The wear surface of steatite ceramic against had craze, accompanied by plough. Scanning electron microscopy showed that zirconia was sintered compactly when subjected to both conventional sintering and microwave methods, whereas grains of zirconia sintered by microwave alone were smaller and more uniform. CONCLUSIONS: Two kinds of sintering methods are successfully used to produce dental zirconia ceramics with similar friction and wear properties.
.
[Mh] Termos MeSH primário: Porcelana Dentária
Fricção
Zircônio
[Mh] Termos MeSH secundário: Cerâmica
Seres Humanos
Óxido de Magnésio
Teste de Materiais
Microscopia Eletrônica de Varredura
Micro-Ondas
Dióxido de Silício
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12001-21-7 (Dental Porcelain); 3A3U0GI71G (Magnesium Oxide); 63210-56-0 (steatite); 7631-86-9 (Silicon Dioxide); C6V6S92N3C (Zirconium); S38N85C5G0 (zirconium oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.7518/hxkq.2017.02.008


  6 / 1378 MEDLINE  
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[PMID]:28647264
[Au] Autor:Elvira GB; Francisco GC; Víctor SM; Alberto MR
[Ad] Endereço:National Institute of Nuclear Research, Department of Chemistry, A.P. 18-1027, Col. Escandón, Miguel Hidalgo Delegation, Zip Code 1180 México D.F., México; Autonomous University of México State, Faculty of Chemistry, Colón avenue, intersection with ride Tollocan s/n Toluca, México, México. Electroni
[Ti] Título:MgO-based adsorbents for CO adsorption: Influence of structural and textural properties on the CO adsorption performance.
[So] Source:J Environ Sci (China);57:418-428, 2017 Jul.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A series of MgO-based adsorbents were prepared through solution-combustion synthesis and ball-milling process. The prepared MgO-based powders were characterized using X-ray diffraction, scanning electron microscopy, N physisorption measurements, and employed as potential adsorbents for CO adsorption. The influence of structural and textural properties of these adsorbents over the CO adsorption behaviour was also investigated. The results showed that MgO-based products prepared by solution-combustion and ball-milling processes, were highly porous, fluffy, nanocrystalline structures in nature, which are unique physico-chemical properties that significantly contribute to enhance their CO adsorption. It was found that the MgO synthesized by solution combustion process, using a molar ratio of urea to magnesium nitrate (2:1), and treated by ball-milling during 2.5hr (MgO-BM2.5h), exhibited the maximum CO adsorption capacity of 1.611mmol/g at 25°C and 1atm, mainly via chemisorption. The CO adsorption behaviour on the MgO-based adsorbents was correlated to their improved specific surface area, total pore volume, pore size distribution and crystallinity. The reusability of synthesized MgO-BM2.5h was confirmed by five consecutive CO adsorption-desorption times, without any significant loss of performance, that supports the potential of MgO-based adsorbent. The results confirmed that the special features of MgO prepared by solution-combustion and treated by ball-milling during 2.5hr are favorable to be used as effective MgO-based adsorbent in post-combustion CO capture technologies.
[Mh] Termos MeSH primário: Dióxido de Carbono/química
Óxido de Magnésio/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Microscopia Eletrônica de Varredura
Porosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); 3A3U0GI71G (Magnesium Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


  7 / 1378 MEDLINE  
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[PMID]:28641222
[Au] Autor:Tang H; Duan Y; Zhu C; Cai T; Li C; Cai L
[Ad] Endereço:Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, Jiangsu 210096, China.
[Ti] Título:Theoretical evaluation on selective adsorption characteristics of alkali metal-based sorbents for gaseous oxidized mercury.
[So] Source:Chemosphere;184:711-719, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alkali metal-based sorbents are potential for oxidized mercury (Hg ) selective adsorption but show hardly effect to elemental mercury (Hg ) in flue gas. Density functional theory (DFT) was employed to investigate the Hg and HgCl adsorption mechanism over alkali metal-based sorbents, including calcium oxide (CaO), magnesium oxide (MgO), potassium chloride (KCl) and sodium chloride (NaCl). Hg was found to weakly interact with CaO (001), MgO (001), KCl (001) and NaCl (001) surfaces while HgCl was effectively adsorbed on top-O and top-Cl sites. Charge transfer and bond population were calculated to discuss the covalency and ionicity of HgCl bonding with the adsorption sites. The partial density of states (PDOS) analysis manifests that HgCl strongly interacts with surface sites through the orbital hybridizations between Hg and top O or Cl. Frontier molecular orbital (FMO) energy and Mulliken electronegativity are introduced as the quantitative criteria to evaluate the reactivity of mercury species and alkali metal-based sorbents. HgCl is identified as a Lewis acid and more reactive than Hg . The Lewis basicity of the four alkali metal-based sorbents is predicted as the increasing order: NaCl < MgO < KCl < CaO, in consistence with the trend of HgCl adsorption energies.
[Mh] Termos MeSH primário: Mercúrio/química
Metais Alcalinos/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Compostos de Cálcio
Gases
Óxido de Magnésio
Cloreto de Mercúrio
Compostos de Mercúrio
Óxidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Gases); 0 (Mercury Compounds); 0 (Metals, Alkali); 0 (Oxides); 3A3U0GI71G (Magnesium Oxide); 53GH7MZT1R (Mercuric Chloride); C7X2M0VVNH (lime); FXS1BY2PGL (Mercury); IY191986AO (mercuric oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE


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[PMID]:28488531
[Au] Autor:Steurer J
[Ad] Endereço:1 Horten-Zentrum für praxisorientierte Forschung und Wissenstransfer, Universitätsspital Zürich.
[Ti] Título:Magnesium bei nächtlichen Wadenkrämpfen sehr wahrscheinlich unwirksam..
[So] Source:Praxis (Bern 1994);106(10):547-548, 2017.
[Is] ISSN:1661-8157
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Óxido de Magnésio/uso terapêutico
Transtornos da Transição Sono-Vigília/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Qualidade de Vida/psicologia
Transtornos da Transição Sono-Vigília/etiologia
Transtornos da Transição Sono-Vigília/psicologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3A3U0GI71G (Magnesium Oxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1024/1661-8157/a002670


  9 / 1378 MEDLINE  
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[PMID]:28417897
[Au] Autor:Moradian ST; Ghiasi MS; Mohamadpour A; Siavash Y
[Ad] Endereço:Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
[Ti] Título:Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial.
[So] Source:Magnes Res;30(1):28-34, 2017 Feb 01.
[Is] ISSN:1952-4021
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gastrointestinal complications are common after coronary artery bypass graft surgery. These complications are ranged from nausea and vomiting to mesenteric ischemia and liver failure. It seems that nausea, vomiting, and constipation are related to magnesium deficiency. This study was designed to examine the effect of oral magnesium supplementation on the incidence of gastrointestinal complications in patients undergoing cardiac surgery. In a single blinded randomized clinical trial, 102 patients who were undergoing coronary artery bypass graft surgery were randomly allocated into two groups, 52 patients in the intervention and 50 patients in control group. Patients in the experimental group received 800 milligram magnesium oxide (2 tablets each of them containing 240 mg elemental magnesium) daily from the admission to discharge from hospital. The incidence of post-operative nausea and vomiting, constipation, and atrial fibrillation was compared between the groups. Our results showed that postoperative hypomagnesemia is present in 41.20 and 70.80 percent of the patients in the intervention and control group patients, respectively. The overall incidence of constipation was 62%. Patients who received magnesium supplementation experienced less atrial fibrillation, nausea, vomiting, and constipation. Our data showed that oral magnesium supplementation could reduce the postoperative complications. Despite the better status in the intervention group, the hypomagnesemia was present in many of intervention group patients. It seems that supplementation with higher doses is needed.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos
Constipação Intestinal/tratamento farmacológico
Óxido de Magnésio/uso terapêutico
Complicações Pós-Operatórias/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Oral
Constipação Intestinal/epidemiologia
Suplementos Nutricionais
Feminino
Seres Humanos
Incidência
Magnésio/sangue
Óxido de Magnésio/administração & dosagem
Óxido de Magnésio/farmacocinética
Masculino
Meia-Idade
Complicações Pós-Operatórias/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3A3U0GI71G (Magnesium Oxide); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1684/mrh.2017.0420


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[PMID]:28342789
[Au] Autor:Van Nguyen H; Baek N; Lee BJ
[Ad] Endereço:College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
[Ti] Título:Enhanced gastric stability of esomeprazole by molecular interaction and modulation of microenvironmental pH with alkalizers in solid dispersion.
[So] Source:Int J Pharm;523(1):189-202, 2017 May 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Due to the instability of esomeprazole magnesium dihydrate (EPM), a proton pump inhibitor, in gastric fluid, enteric-coated dosage form is commonly used for therapeutic application. In this study, we prepared new gastric fluid resistant solid dispersions (SDs) containing alkalizers. Then, new mechanistic evidence regarding the effects of pharmaceutical alkalizers on the aqueous stability of EPM in simulated gastric fluid was investigated. The alkalizer-loaded SD were prepared by dissolving or dispersing EPM, hydroxypropyl methylcellulose (HPMC) 6 cps, and an alkalizer, in ethanol 50% (v/v) followed by spray drying. Nine different alkalizers were assessed for in vitro stability in two media, simulated gastric fluid (pH 1.2 buffer) and simulated intestinal fluid (pH 6.8 buffer). The microenvironmental pH (pH ) was measured to evaluate the effect of the alkalizer on the pH of SDs. Drug crystallinity and morphology of the SDs were also examined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The interactions among EPM, the polymer, and the alkalizer were elucidated by Fourier transform infrared (FTIR) spectroscopy. The in vivo absorption studies of the optimized alkalizer-containing SD and the enteric-coated reference tablet Nexium were then conducted in beagle dogs. Among alkalizers, MgO loaded in SDs proved to be the best alkalizer to stabilize EPM in simulated gastric fluid. pH values of the alkalizer-containing SDs were significantly higher than that of the SD without alkalizer. The pH values decreased in the following order: MgO, Na CO , Ca(OH) , and no alkalizer. DSC and PXRD data exhibited a change in the drug crystallinity of the SDs from crystalline to amorphous form. SEM data showed a relatively spherical shape of the MgO-loaded SD compared to the less-defined shape of pure drug. FTIR indicated a strong molecular interaction among EPM, alkalizer and polymer; in particular, MgO showed the strongest interaction with EPM. It was evident that alkalizer interacts with benzimidazole ring and/or sulfonyl group of EPM for enhancing EPM stability in gastric fluid. Regarding the in vivo absorption studies in beagle dogs, the optimized SD (C16) was bioequivalent to the reference Nexium and had a considerable greater absorption at the early stages. The current alkalizer-containing SD could provide a promising approach for aqueous stabilization of acid-labile drugs without using enteric coating method.
[Mh] Termos MeSH primário: Esomeprazol/química
Inibidores da Bomba de Prótons/química
[Mh] Termos MeSH secundário: Animais
Hidróxido de Cálcio/química
Varredura Diferencial de Calorimetria
Carbonatos/química
Química Farmacêutica
Cães
Estabilidade de Medicamentos
Esomeprazol/administração & dosagem
Esomeprazol/farmacocinética
Suco Gástrico/química
Concentração de Íons de Hidrogênio
Absorção Intestinal
Óxido de Magnésio/química
Microscopia Eletrônica de Varredura
Difração de Pó
Inibidores da Bomba de Prótons/administração & dosagem
Inibidores da Bomba de Prótons/farmacocinética
Espectroscopia de Infravermelho com Transformada de Fourier
Estômago/metabolismo
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbonates); 0 (Proton Pump Inhibitors); 3A3U0GI71G (Magnesium Oxide); 45P3261C7T (sodium carbonate); N3PA6559FT (Esomeprazole); PF5DZW74VN (Calcium Hydroxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE



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