Base de dados : MEDLINE
Pesquisa : D01.524.500 [Categoria DeCS]
Referências encontradas : 393 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 40 ir para página                         

  1 / 393 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28553104
[Au] Autor:Wu Z; Li Q; Pan Y; Yao Y; Tang S; Su J; Shin JW; Wei J; Zhao J
[Ad] Endereço:Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology.
[Ti] Título:Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate.
[So] Source:Int J Nanomedicine;12:3637-3651, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting-particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu composite (MPC) scaffold. In addition, the NMPC scaffold showed improved apatite mineralization ability, indicating better bioactivity, as the NMPC containing nanoporosity could induce more apatite and homogeneous apatite layer on the surfaces than MPC scaffold. The attachment and proliferation of MC3T3-E1 cells on NMPC scaffold increased significantly compared with MPC scaffold, and the alkaline phosphatase (ALP) activity of the cells on NMPC scaffold was expressed at considerably higher levels compared with MPC scaffold. Moreover, NMPC scaffold with nanoporosity not only had large drug loading (vancomycin) but also exhibited drug sustained release. The results suggested that the incorporation of NMS into PBSu could produce bioactive composite scaffold with nanoporosity, which could enhance water absorption, degradability, apatite mineralization and drug sustained release and promote cell responses.
[Mh] Termos MeSH primário: Butileno Glicóis/química
Silicatos de Magnésio/química
Nanoestruturas/química
Osteoblastos/fisiologia
Polímeros/química
Tecidos Suporte
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Apatitas/química
Materiais Biocompatíveis/química
Linhagem Celular
Proliferação Celular
Liberação Controlada de Fármacos
Camundongos
Nanoporos
Osteoblastos/citologia
Vancomicina/farmacocinética
Água/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apatites); 0 (Biocompatible Materials); 0 (Butylene Glycols); 0 (Magnesium Silicates); 0 (Polymers); 0 (bionole); 059QF0KO0R (Water); 6Q205EH1VU (Vancomycin); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S132778


  2 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28415507
[Au] Autor:Gu Z; Wang S; Weng W; Chen X; Cao L; Wei J; Shin JW; Su J
[Ad] Endereço:Department of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; The Department of Orthopaedics, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'An Branch), 200040, China.
[Ti] Título:Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:620-628, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, composite cements containing mesoporous magnesium silicate (m-MS) and calcium sulfate (CS) were fabricated. The results revealed that the setting time of the m-MS/CS composite cements (m-MSC) slightly prolonged with the increase of m-MS content while the compressive strength suffered a little loss. The doping of m-MS improved the water absorption, drug release (vancomycin) and degradability of the m-MSC in Tris-HCl solution (pH=7.4). In addition, addition of m-MS facilitated the apatite-mineralization of m-MSC in simulated body fluid (SBF), indicating good bioactivity. For cell cultural experiments, the results revealed that the m-MSC promoted the cells adhesion and proliferation, and improved the alkaline phosphatase (ALP) activity of MC3T3-E1 cells, revealing good cytocompatibility. It could be suggested that the m-MSC might be promising cements biomaterials for bone tissue regeneration.
[Mh] Termos MeSH primário: Apatitas
Cimentos para Ossos
Sulfato de Cálcio
Silicatos de Magnésio
Teste de Materiais
Água/química
[Mh] Termos MeSH secundário: Animais
Apatitas/química
Apatitas/farmacocinética
Apatitas/farmacologia
Cimentos para Ossos/química
Cimentos para Ossos/farmacocinética
Cimentos para Ossos/farmacologia
Regeneração Óssea/efeitos dos fármacos
Sulfato de Cálcio/química
Sulfato de Cálcio/farmacocinética
Sulfato de Cálcio/farmacologia
Linhagem Celular
Preparações de Ação Retardada/química
Preparações de Ação Retardada/farmacocinética
Preparações de Ação Retardada/farmacologia
Silicatos de Magnésio/química
Silicatos de Magnésio/farmacocinética
Silicatos de Magnésio/farmacologia
Camundongos
Porosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apatites); 0 (Bone Cements); 0 (Delayed-Action Preparations); 0 (Magnesium Silicates); 059QF0KO0R (Water); 1343-88-0 (Florisil); WAT0DDB505 (Calcium Sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  3 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28380218
[Au] Autor:Acharya M; Mishra S; Sahoo RN; Mallick S
[Ti] Título:Infrared Spectroscopy for Analysis of Co-processed Ibuprofen and Magnesium Trisilicate at Milling and Freeze Drying.
[So] Source:Acta Chim Slov;64(1):45-54, 2017 Mac.
[Is] ISSN:1318-0207
[Cp] País de publicação:Slovenia
[La] Idioma:eng
[Ab] Resumo:Assessment of interactions of ibuprofen and magnesium trisilicate after co-processing has been carried out by infrared spectroscopy. Dry-state ball-milling and, aqueous state kneading and freeze-drying were performed. FTIR spectroscopy of co-processed materials described acid-base reaction between the carboxylic acid containing ibuprofen to a significant extent. Increased absorbance of carboxylate peak accompanied by a consistently reduced absorbance of the carbonyl acid peak was evident. Absorbance of carboxylate peak was more in freeze-dried sample compared to milled product. Intermolecular hydrogen bonding between ibuprofen and magnesium trisilicate in the co-processed material has been suggested. Inhibition of crystal morphology has been noticed in the photomicrographs of both the products. DSC report has shown absence or significantly decreased melting endotherm representing almost complete amorphization of ibuprofen. Release of drug increased greatly after co-processing in comparison to crystalline ibuprofen. Freeze-dried samples have improved drug release more significantly compared to ball-milled samples.
[Mh] Termos MeSH primário: Química Farmacêutica
Liofilização
Ibuprofeno/análise
Silicatos de Magnésio/análise
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Técnicas In Vitro
Microscopia Eletrônica de Varredura
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Magnesium Silicates); C2E1CI501T (magnesium trisilicate); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


  4 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28319859
[Au] Autor:Li J; Xu Y
[Ad] Endereço:Taiyuan Institute of Technology, Taiyuan 030008, China. Electronic address: jianrui-419@163.com.
[Ti] Título:Use of clay to remediate cadmium contaminated soil under different water management regimes.
[So] Source:Ecotoxicol Environ Saf;141:107-112, 2017 Jul.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We examined in situ remediation of sepiolite on cadmium-polluted soils with diverse water regimes, and several variables including brown rice Cd, exchangeable Cd, pH, and available Fe/P. pH, available Fe/P in soils increased gradually during continuous flooding, which contributed to Cd absorption on colloids. In control group (untreated soils), compared to conventional irrigation, brown rice Cd in continuous flooding reduced by 37.9%, and that in wetting irrigation increased by 31.0% (p<0.05). In contrast to corresponding controls, brown rice Cd in sepiolite treated soils reduced by 44.4%, 34.5% and 36.8% under continuous flooding, conventional irrigation and wetting irrigation (p<0.05), and exchangeable Cd in amended soils reduced by 27.5-49.0%, 14.3-40.5%, and 24.9-32.8% under three water management regimes (p<0.05). Compared to corresponding controls, decreasing amplitudes of exchangeable Cd and brown rice Cd in sepiolite treated soils were higher in continuous flooding than in conventional irrigation and wetting irrigation. Continuous flooding management promoted soil Cd immobilization by sepiolite.
[Mh] Termos MeSH primário: Silicatos de Alumínio/química
Cádmio/análise
Silicatos de Magnésio/química
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Irrigação Agrícola
Recuperação e Remediação Ambiental
Inundações
Oryza/química
Oryza/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Magnesium Silicates); 0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 1302-87-0 (clay); C2E1CI501T (magnesium trisilicate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


  5 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28277176
[Au] Autor:Chiesa LM; Labella GF; Panseri S; Britti D; Galbiati F; Villa R; Arioli F
[Ad] Endereço:a Department of Health, Animal Science and Food Safety , University of Milan , Milan , Italy.
[Ti] Título:Accelerated solvent extraction by using an 'in-line' clean-up approach for multiresidue analysis of pesticides in organic honey.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;34(5):809-818, 2017 May.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The worldwide loss of honeybee colonies may be due to their exposure to several contaminants (i.e., pesticides); such contamination may also have impacts on consumers' health. Therefore, it is essential to develop quick and new methods to detect several pesticide residues in honey samples. In this study, the effectiveness of accelerated solvent extraction (ASE) was compared with QuEChERS methods for the analysis of 53 pesticides in organic honey by gas chromatography-triple quadrupole mass spectrometry. Two simple and rapid ASE methods with 'in-line' clean-up were optimised and then compared with QuEChERS. Hexane-ethyl acetate (Hex:EtAc) and Florisil were chosen as extraction solvent and retainer for the first ASE method respectively; acetonitrile and a primary-secondary amine phase (ACN-PSA) were selected for the second ASE method. The methods were validated according to the European Union SANTE/11945/2015 guidelines. The validation parameters showed that QuEChERS and ASE with PSA as retainer had better repeatability than ASE with Hex:EtAc and Florisil. In particular, QuEChERS and ASE (ACN-PSA) showed good recovery, according to the SANTE criteria, for the majority of investigated pesticides. Conversely, when ASE with Hex:EtAc and Florisil was used as the retainer, several compounds showed recoveries lower than the acceptable value of 70%. The ASE in-line method was finally applied to evaluate pesticide concentration in organic honey samples.
[Mh] Termos MeSH primário: Acetatos/química
Contaminação de Alimentos/análise
Hexanos/química
Mel/análise
Silicatos de Magnésio/química
Praguicidas/análise
Solventes/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Hexanes); 0 (Magnesium Silicates); 0 (Pesticides); 0 (Solvents); 1343-88-0 (Florisil); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2017.1292558


  6 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28272032
[Au] Autor:Cheng Z; Yang R; Wang Y
[Ad] Endereço:State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, No. 381, Wushan Road, Tianhe District, Guangzhou, CN 510641, China E-mail: 954867716@qq.com; State Key Laboratory of Pulp and Paper Engineering, Plant Micro/nano Fiber Research Center, School of Light Industry and Engineering, South China University of Technology, No. 381, Wushan Road, Tianhe District, Guangzhou, CN 510641, China.
[Ti] Título:Mn/sepiolite as the heterogeneous ozonation catalysts applied to the advanced treatment of regenerated-papermaking wastewater.
[So] Source:Water Sci Technol;75(5-6):1025-1033, 2017 03.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herein a Mn-deposited sepiolite catalyst was obtained through a facile co-precipitation method, and then used as the heterogeneous ozonation catalysts applied to the tertiary treatment of regenerated-papermaking wastewater. During the process, the as-prepared catalyst was endowed with higher Brunauer-Emmett-Teller specific surface area of 412.3 m /g compared to 124.6 m /g of the natural sepiolite. Hence, in the adsorption of methylene blue, the as-prepared catalyst was observed with a very high removal rate of 96.2% although a little lower than the modified sepiolite of 97.5% in 100 min. And for practical application, the catalyst was used for treating the effluent from regenerated-papermaking industry, via a heterogeneous catalytic ozonation process. Consequently, the highest color removal rate of 99.5%, and the highest chemical oxygen demand (COD) removal efficiency of 73.4% were achieved in 20 and 30 min, respectively. As a result, the treated wastewater was more biodegradable and less toxic; the biochemical oxygen demand (BOD )/COD value could reach 0.41. Moreover, the catalyst showed superior stability at successive ozonation runs. The main possible reaction pathway is also presented. The results indicate that catalytic ozonation was proved to be effective when Mn/sepiolite was used as catalysts applied to the advanced treatment of regenerated-papermaking wastewater.
[Mh] Termos MeSH primário: Silicatos de Magnésio/química
Ozônio/química
Papel
Reciclagem
Águas Residuais
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Análise da Demanda Biológica de Oxigênio
Catálise
Cor
Compostos Orgânicos/isolamento & purificação
Poluentes Químicos da Água/isolamento & purificação
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Magnesium Silicates); 0 (Organic Chemicals); 0 (Waste Water); 0 (Water Pollutants, Chemical); 66H7ZZK23N (Ozone); C2E1CI501T (magnesium trisilicate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2016.583


  7 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28260883
[Au] Autor:Cao L; Weng W; Chen X; Zhang J; Zhou Q; Cui J; Zhao Y; Shin JW; Su J
[Ad] Endereço:Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
[Ti] Título:Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate.
[So] Source:Int J Nanomedicine;12:1341-1352, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects.
[Mh] Termos MeSH primário: Cimentos para Ossos/farmacologia
Osso e Ossos/efeitos dos fármacos
Sulfato de Cálcio/química
Lítio/química
Silicatos de Magnésio/química
Neovascularização Fisiológica/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/efeitos dos fármacos
Feminino
Fêmur/efeitos dos fármacos
Fêmur/metabolismo
Técnicas Imunoenzimáticas
Coelhos
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Cements); 0 (Magnesium Silicates); 0 (Vascular Endothelial Growth Factor A); 9FN79X2M3F (Lithium); WAT0DDB505 (Calcium Sulfate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S124965


  8 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28185866
[Au] Autor:Ren J; Lee H; Yoo SM; Yu MS; Park H; Na D
[Ad] Endereço:School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
[Ti] Título:Combined chemical and physical transformation method with RbCl and sepiolite for the transformation of various bacterial species.
[So] Source:J Microbiol Methods;135:48-51, 2017 Apr.
[Is] ISSN:1872-8359
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:DNA transformation that delivers plasmid DNAs into bacterial cells is fundamental in genetic manipulation to engineer and study bacteria. Developed transformation methods to date are optimized to specific bacterial species for high efficiency. Thus, there is always a demand for simple and species-independent transformation methods. We herein describe the development of a chemico-physical transformation method that combines a rubidium chloride (RbCl)-based chemical method and sepiolite-based physical method, and report its use for the simple and efficient delivery of DNA into various bacterial species. Using this method, the best transformation efficiency for Escherichia coli DH5α was 4.3×10 CFU/µg of pUC19 plasmid, which is higher than or comparable to the reported transformation efficiencies to date. This method also allowed the introduction of plasmid DNAs into Bacillus subtilis (5.7×10 CFU/µg of pSEVA3b67Rb), Bacillus megaterium (2.5×10 CFU/µg of pSPAsp-hp), Lactococcus lactis subsp. lactis (1.0×10 CFU/µg of pTRKH3-ermGFP), and Lactococcus lactis subsp. cremoris (2.2×10 CFU/µg of pMSP3535VA). Remarkably, even when the conventional chemical and physical methods failed to generate transformed cells in Bacillus sp. and Enterococcus faecalis, E. malodoratus and E. mundtii, our combined method showed a significant transformation efficiency (2.4×10 , 4.5×10 , 2×10 , and 0.5×10 CFU/µg of plasmid DNA). Based on our results, we anticipate that our simple and efficient transformation method should prove usefulness for introducing DNA into various bacterial species without complicated optimization of parameters affecting DNA entry into the cell.
[Mh] Termos MeSH primário: Bactérias/genética
Cloretos/farmacologia
DNA Bacteriano/genética
Técnicas de Transferência de Genes
Silicatos de Magnésio/farmacologia
Rubídio/farmacologia
Transformação Bacteriana/efeitos dos fármacos
[Mh] Termos MeSH secundário: Bacillus/genética
Bacillus megaterium/genética
Bacillus subtilis/genética
Enterococcus faecalis/genética
Escherichia coli/genética
Lactococcus lactis
Plasmídeos/genética
Transformação Bacteriana/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (DNA, Bacterial); 0 (Magnesium Silicates); C2E1CI501T (magnesium trisilicate); MLT4718TJW (Rubidium); N3SHC5273S (rubidium chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


  9 / 393 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28017870
[Au] Autor:Fiocco L; Li S; Stevens MM; Bernardo E; Jones JR
[Ad] Endereço:Dipartimento di Ingegneria Industriale, University of Padova, Via Marzolo, 9, 35131 Padova, Italy.
[Ti] Título:Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics.
[So] Source:Acta Biomater;50:56-67, 2017 Mar 01.
[Is] ISSN:1878-7568
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Magnesium is a trace element in the human body, known to have important effects on cell differentiation and the mineralisation of calcified tissues. This study aimed to synthesise highly porous Ca-Mg silicate foamed scaffolds from preceramic polymers, with analysis of their biological response. Akermanite (Ak) and wollastonite-diopside (WD) ceramic foams were obtained from the pyrolysis of a liquid silicone mixed with reactive fillers. The porous structure was obtained by controlled water release from selected fillers (magnesium hydroxide and borax) at 350°C. The homogeneous distribution of open pores, with interconnects of modal diameters of 160-180µm was obtained and maintained after firing at 1100°C. Foams, with porosity exceeding 80%, exhibited compressive strength values of 1-2MPa. In vitro studies were conducted by immersion in SBF for 21days, showing suitable dissolution rates, pH and ionic concentrations. Cytotoxicity analysis performed in accordance with ISO10993-5 and ISO10993-12 standards confirmed excellent biocompatibility of both Ak and WD foams. In addition, MC3T3-E1 cells cultured on the Mg-containing scaffolds demonstrated enhanced osteogenic differentiation and the expression of osteogenic markers including Collagen Type I, Osteopontin and Osteocalcin, in comparison to Mg-free counterparts. The results suggest that the addition of magnesium can further enhance the bioactivity and the potential for bone regeneration applications of Ca-silicate materials. STATEMENTS OF SIGNIFICANCE: Here, we show that the incorporation of Mg in Ca-silicates plays a significant role in the enhancement of the osteogenic differentiation and matrix formation of MC3T3-E1 cells, cultured on polymer-derived highly porous scaffolds. Reduced degradation rates and improved mechanical properties are also observed, compared to Mg-free counterparts, suggesting the great potential of Ca-Mg silicates as bone tissue engineering materials. Excellent biocompatibility of the new materials, in accordance to the ISO10993-5 and ISO10993-12 standard guidelines, confirms the preceramic polymer route as an efficient synthesis methodology for bone scaffolds. The use of hydrated fillers as porogens is an additional novelty feature presented in the manuscript.
[Mh] Termos MeSH primário: Compostos de Cálcio
Cerâmica
Silicatos de Magnésio
Teste de Materiais
Silicatos
[Mh] Termos MeSH secundário: Animais
Antígenos de Diferenciação/biossíntese
Compostos de Cálcio/química
Compostos de Cálcio/farmacologia
Diferenciação Celular/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cerâmica/síntese química
Cerâmica/química
Cerâmica/farmacologia
Força Compressiva
Silicatos de Magnésio/química
Silicatos de Magnésio/farmacologia
Camundongos
Porosidade
Silicatos/química
Silicatos/farmacologia
Ácido Silícico/química
Ácido Silícico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Differentiation); 0 (Calcium Compounds); 0 (Magnesium Silicates); 0 (Silicates); 1343-88-0 (Florisil); 1343-98-2 (Silicic Acid); 14483-19-3 (diopside); 85422-94-2 (Glass ceramics); S4255P4G5M (calcium silicate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


  10 / 393 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27766485
[Au] Autor:Carvajal P; Dinamarca MA; Baeza P; Camú E; Ojeda J
[Ad] Endereço:Laboratorio de Biotecnología Microbiana, Escuela de Nutrición, Facultad de Farmacia, Universidad de Valparaíso, Casilla 5001, Valparaíso, Chile.
[Ti] Título:Removal of sulfur-containing organic molecules adsorbed on inorganic supports by Rhodococcus Rhodochrous spp.
[So] Source:Biotechnol Lett;39(2):241-245, 2017 Feb.
[Is] ISSN:1573-6776
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To remove dibenzothiophene (DBT) and 4,6-dimethyl-dibenzothiophene (4,6-DMDBT) adsorbed on alumina, silica and sepiolite through biodesulfurization (BDS) using Rhodococcus Rhodochrous spp., that selectively reduce sulfur molecules without generating of gaseous pollutants. RESULTS: The adsorption of DBT and 4,6-DMDBT was affected by the properties of the supports, including particle size and the presence of surface acidic groups. The highest adsorption of both sulfur-containing organic molecules used particle sizes of 0.43-0.063 mm. The highest percentage removal was with sepiolite (80 % for DBT and 56 % for 4,6-DMDBT) and silica (71 % for DBT and 37 % for 4,6-DMDBT). This is attributed to the close interaction between these supports and the bacteria. CONCLUSIONS: Biodesulfurization is effective for removing the sulfur-containing organic molecules adsorbed on inorganic materials and avoids the generation of gaseous pollutants.
[Mh] Termos MeSH primário: Rhodococcus/metabolismo
Enxofre/metabolismo
[Mh] Termos MeSH secundário: Adsorção
Óxido de Alumínio/química
Biodegradação Ambiental
Silicatos de Magnésio/química
Dióxido de Silício/química
Enxofre/química
Tiofenos/química
Tiofenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4,6-dimethyldibenzothiophene); 0 (Magnesium Silicates); 0 (Thiophenes); 70FD1KFU70 (Sulfur); 7631-86-9 (Silicon Dioxide); C2E1CI501T (magnesium trisilicate); LMI26O6933 (Aluminum Oxide); Z3D4AJ1R48 (dibenzothiophene)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE
[do] DOI:10.1007/s10529-016-2240-y



página 1 de 40 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde