Base de dados : MEDLINE
Pesquisa : D01.530 [Categoria DeCS]
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  1 / 3018 MEDLINE  
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[PMID]:29175397
[Au] Autor:Dong G; Huang L; Wu X; Wang C; Liu Y; Liu G; Wang L; Liu X; Xia H
[Ad] Endereço:Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, China. Electronic address: 963722867@qq.com.
[Ti] Título:Effect and mechanism analysis of MnO on permeable reactive barrier (PRB) system for the removal of tetracycline.
[So] Source:Chemosphere;193:702-710, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Effect of manganese dioxide (MnO ) on tetracycline (TC) removal/degradation in zero-valent iron (ZVI) based permeable reactive barrier (PRB) system was investigated. To analyze the role of MnO , three different PRB columns packed with ZVI, ZVI and a layer of MnO , and MnO were set up to investigate the removal effect and reaction mechanism of ZVI coupling with MnO on TC removal, respectively. The results show that the removal efficiencies of three PRB columns are 65%, 85%, and 50%, respectively. MnO could accelerate the transformation of Fe into Fe and combine with Fe to degrade TC in different reaction sites in the ZVI-MnO PRB system. Hydroxyl radicals (·OH) were produced in this process, which contributed to about 58.3% for the TC degradation. The UV-Vis spectrum demonstrated that A ring of TC was the main reaction site for interaction with Fe and the BCD rings were crucial for interactions with MnO . On the basis of intermediates identified by LC-ESI-MS, the ring structure of TC was opened, and low-molecular-weight compounds were produced in ZVI-MnO PRB system.
[Mh] Termos MeSH primário: Ferro/química
Compostos de Manganês/farmacologia
Óxidos/farmacologia
Tetraciclina/isolamento & purificação
[Mh] Termos MeSH secundário: Sítios de Ligação
Cromatografia Líquida
Estrutura Molecular
Espectrometria de Massas em Tandem
Tetraciclina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); E1UOL152H7 (Iron); F8VB5M810T (Tetracycline); TF219GU161 (manganese dioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  2 / 3018 MEDLINE  
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[PMID]:27777173
[Au] Autor:Poole DS; Doorenweerd N; Plomp JJ; Mahfouz A; Reinders MJT; van der Weerd L
[Ad] Endereço:Department of Radiology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: D.Poole@lumc.nl.
[Ti] Título:Continuous infusion of manganese improves contrast and reduces side effects in manganese-enhanced magnetic resonance imaging studies.
[So] Source:Neuroimage;147:1-9, 2017 Feb 15.
[Is] ISSN:1095-9572
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability to administer systemically high doses of manganese as contrast agent while circumventing its toxicity is of particular interest for exploratory MRI studies of the brain. Administering low doses either repeatedly or continuously over time has been shown to enable the acquisition of satisfactory MRI images of the mouse brain without apparent side effects. Here we have systematically compared the obtained MRI contrast and recorded potential systemic side effects such as stress response and muscle strength impairment in relation to the achieved contrast. We show in mice that administering MnCl via osmotic infusion pumps allows for a side-effect free delivery of a high cumulative dose of manganese chloride (480mg/kg bodyweight in 8 days). High contrast in MRI was achieved while we did not observe the weight loss or distress seen in other studies where mice received manganese via fractionated intraperitoneal injections of lower doses of manganese. As the normal daily conduct of the mice was not affected, this new manganese delivery method might be of particular use to study brain activity over several days. This may facilitate the phenotyping of new transgenic mouse models, the study of chronic disease models and the monitoring of changes in brain activity in long-term behavioral studies.
[Mh] Termos MeSH primário: Cloretos/administração & dosagem
Cloretos/farmacologia
Meios de Contraste/administração & dosagem
Meios de Contraste/farmacologia
Imagem por Ressonância Magnética/métodos
Compostos de Manganês/administração & dosagem
Compostos de Manganês/farmacologia
[Mh] Termos MeSH secundário: Animais
Cloretos/efeitos adversos
Meios de Contraste/efeitos adversos
Corticosterona/sangue
Aumento da Imagem
Bombas de Infusão
Infusões Intravenosas
Injeções Intraperitoneais
Masculino
Compostos de Manganês/efeitos adversos
Camundongos
Camundongos Endogâmicos C57BL
Força Muscular/efeitos dos fármacos
Estresse Psicológico/induzido quimicamente
Estresse Psicológico/psicologia
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Contrast Media); 0 (Manganese Compounds); QQE170PANO (manganese chloride); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  3 / 3018 MEDLINE  
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[PMID]:28460583
[Au] Autor:Nielsen BS; Larsen EH; Ladefoged O; Lam HR
[Ad] Endereço:1 Environment and Toxicology, DHI, Hørsholm, Denmark.
[Ti] Título:Subchronic, Low-Level Intraperitoneal Injections of Manganese (IV) Oxide and Manganese (II) Chloride Affect Rat Brain Neurochemistry.
[So] Source:Int J Toxicol;36(3):239-251, 2017 May/Jun.
[Is] ISSN:1092-874X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0.9% NaCl (control), 1.22 mg Mn (as MnO )/kg bodyweight (bw)/day, or 2.5 mg Mn (as MnCl )/kg bw/day for 7 d/wk for 8 or 12 weeks. This dosing regimen adds relevant new knowledge about Mn neurotoxicity as a consequence of low-dose subchronic Mn dosing. Manganese concentrations increased in the striatum, the rest of the brain, and in plasma, and regional brain neurotransmitter concentrations, including noradrenaline, dopamine (DA), 5-hydroxytrytamine, glutamate, taurine, and γ-amino butyric acid, and the activity of acetylcholinesterase changed. Importantly, a target parameter for Parkinson disease and manganism, the striatal DA concentration, was reduced after 12 weeks of dosing with MnCl . Plasma prolactin concentration was not significantly affected due to a potentially reduced dopaminergic inhibition of the prolactin release from the anterior hypophysis. No effects on the striatal α-synuclein and synaptophysin protein levels were detected.
[Mh] Termos MeSH primário: Química Encefálica/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Cloretos/toxicidade
Óxidos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Encéfalo/metabolismo
Cloretos/sangue
Cloretos/farmacocinética
Dopamina/metabolismo
Ácido Glutâmico/metabolismo
Injeções Intraperitoneais
Masculino
Manganês/sangue
Manganês/metabolismo
Compostos de Manganês/sangue
Compostos de Manganês/farmacocinética
Norepinefrina/metabolismo
Óxidos/sangue
Óxidos/farmacocinética
Ratos Sprague-Dawley
Serotonina/metabolismo
Taurina/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Manganese Compounds); 0 (Oxides); 1EQV5MLY3D (Taurine); 333DO1RDJY (Serotonin); 3KX376GY7L (Glutamic Acid); 42Z2K6ZL8P (Manganese); 56-12-2 (gamma-Aminobutyric Acid); 64J2OA7MH3 (manganese oxide); EC 3.1.1.7 (Acetylcholinesterase); QQE170PANO (manganese chloride); VTD58H1Z2X (Dopamine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1177/1091581817704378


  4 / 3018 MEDLINE  
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[PMID]:29478649
[Au] Autor:Xia Y; Xia L; Liu Y; Yang T; Deng J; Dai H
[Ad] Endereço:College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, China; Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, MOE Key Laboratory of Enhanced Heat Transfer and Energy Conservation, and College of Environ
[Ti] Título:Concurrent catalytic removal of typical volatile organic compound mixtures over Au-Pd/α-MnO nanotubes.
[So] Source:J Environ Sci (China);64:276-288, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:α-MnO nanotubes and their supported Au-Pd alloy nanocatalysts were prepared using hydrothermal and polyvinyl alcohol-protected reduction methods, respectively. Their catalytic activity for the oxidation of toluene/m-xylene, acetone/ethyl acetate, acetone/m-xylene and ethyl acetate/m-xylene mixtures was evaluated. It was found that the interaction between Au-Pd alloy nanoparticles and α-MnO nanotubes significantly improved the reactivity of lattice oxygen, and the 0.91wt.% Au Pd/α-MnO nanotube catalyst outperformed the α-MnO nanotube catalyst in the oxidation of toluene, m-xylene, ethyl acetate and acetone. Over the 0.91wt.% Au Pd/α-MnO nanotube catalyst, (i) toluene oxidation was greatly inhibited in the toluene/m-xylene mixture, while m-xylene oxidation was not influenced; (ii) acetone and ethyl acetate oxidation suffered a minor impact in the acetone/ethyl acetate mixture; and (iii) m-xylene oxidation was enhanced whereas the oxidation of the oxygenated VOCs (volatile organic compounds) was suppressed in the acetone/m-xylene or ethyl acetate/m-xylene mixtures. The competitive adsorption of these typical VOCs on the catalyst surface induced an inhibitive effect on their oxidation, and increasing the temperature favored the oxidation of the VOCs. The mixed VOCs could be completely oxidized into CO and H O below 320°C at a space velocity of 40,000mL/(g·hr). The 0.91wt.% Au Pd/α-MnO nanotube catalyst exhibited high catalytic stability as well as good tolerance to water vapor and CO in the oxidation of the VOC mixtures. Thus, the α-MnO nanotube-supported noble metal alloy catalysts hold promise for the efficient elimination of VOC mixtures.
[Mh] Termos MeSH primário: Modelos Químicos
Nanotubos/química
Compostos Orgânicos Voláteis/química
[Mh] Termos MeSH secundário: Catálise
Ouro/química
Compostos de Manganês/química
Óxidos/química
Paládio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); 0 (Volatile Organic Compounds); 5TWQ1V240M (Palladium); 7440-57-5 (Gold); TF219GU161 (manganese dioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


  5 / 3018 MEDLINE  
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[PMID]:28467843
[Au] Autor:Pan H; Jian Y; Chen C; He C; Hao Z; Shen Z; Liu H
[Ad] Endereço:Department of Environmental Science and Engineering, State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University , Xi'an, 710049, P.R. China.
[Ti] Título:Sphere-Shaped Mn O Catalyst with Remarkable Low-Temperature Activity for Methyl-Ethyl-Ketone Combustion.
[So] Source:Environ Sci Technol;51(11):6288-6297, 2017 Jun 06.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mn O , FeMnO , and FeO catalysts synthesized via a solvothermal method were employed for catalytic oxidation of methyl-ethyl-ketone (MEK) at low temperature. Mn O with sphere-like morphology exhibited the highest activity for MEK oxidation, over which MEK was completely oxidized to CO at 200 °C, and this result can be comparable to typical noble metal loaded catalysts. The activation energy of MEK over Mn O (30.8 kJ/mol) was much lower than that of FeMnO (41.5 kJ/mol) and FeO (47.8 kJ/mol). The dominant planes, surface manganese species ratio, surface-absorbed oxygen, and redox capability played important roles in the catalytic activities of catalysts, while no significant correlation was found between specific surface area and MEK removal efficiency. Mn O showed the highest activity, accounting for abundant oxygen vacancies, low content of surface Mn and strong reducibility. The oxidation of MEK to CO via an intermediate of diacetyl is a reaction pathway on Mn O catalyst. Due to high efficiency and low cost, sphere-shaped Mn O is a promising catalyst for VOCs abatement.
[Mh] Termos MeSH primário: Compostos de Manganês
Óxidos
Temperatura Ambiente
[Mh] Termos MeSH secundário: Catálise
Oxirredução
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); 64J2OA7MH3 (manganese oxide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b00136


  6 / 3018 MEDLINE  
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[PMID]:28454008
[Au] Autor:Zhao X; Ma J; von Gunten U
[Ad] Endereço:State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China; Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, CH-8600 Dübendorf, Switzerland.
[Ti] Título:Reactions of hypoiodous acid with model compounds and the formation of iodoform in absence/presence of permanganate.
[So] Source:Water Res;119:126-135, 2017 08 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The kinetics for the reactions of hypoiodous acid (HOI) with various phenols (phenol, 4-nitrophenol, 4-hydroxybenzoic acid), 3-oxopentanedioic acid (3-OPA) and flavone were investigated in the pH range of 6.0-11.0. The apparent second order rate constants for the reactions of HOI with phenolic compounds, 3-OPA, flavone and citric acid at pH 8.0 are 10-10 M s , (4.0 ± 0.3) × 10 M s , (2.5 ± 0.2) × 10 M s and <1 M s , respectively. The effect of buffer type and concentration was investigated with acetate, phosphate and borate. All tested buffers promote the HOI reactions with phenols. The percentage of iodine incorporation for various (hydroxyl)phenolic compounds and two NOM extracts ranges from 5% to 98%, indicating that electrophilic aromatic substitution and/or electron transfer can occur. The extent of these reactions depends on the number and relative position of the hydroxyl moieties on the phenolic compounds. Iodoform formation rates increase with increasing pH and iodoform yields increase from 9% to 67% for pH 6.0-10.0 for the HOI/3-OPA reactions. In the permanganate/HOI/3-OPA and permanganate/iodide/3-OPA system at pH < 8.0, iodoform formation is elevated compared to the HOI/3-OPA system in absence of permanganate. For pH > 8.0, in presence of permanganate, iodoform formation is significantly inhibited and iodate formation enhanced, which is due to a faster permanganate-mediated HOI disproportionation to iodate compared to the iodination process. The production of reactive iodine in real waters containing iodide in contact with permanganate may lead to the formation of iodinated organic compounds.
[Mh] Termos MeSH primário: Compostos de Iodo/química
Compostos de Manganês/química
Óxidos/química
Purificação da Água
[Mh] Termos MeSH secundário: Hidrocarbonetos Iodados
Concentração de Íons de Hidrogênio
Cinética
Oxirredução
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydrocarbons, Iodinated); 0 (Iodine Compounds); 0 (Manganese Compounds); 0 (Oxides); 0 (Water Pollutants, Chemical); 14333-13-2 (permanganic acid); 2PYC923C5W (hypoiodous acid); KXI2J76489 (iodoform)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  7 / 3018 MEDLINE  
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[PMID]:29016622
[Au] Autor:Lamb JJ; Hohmann-Marriott MF
[Ad] Endereço:Department of Biotechnology & PhotoSynLab, NTNU, Trondheim, Norway.
[Ti] Título:Manganese acquisition is facilitated by PilA in the cyanobacterium Synechocystis sp. PCC 6803.
[So] Source:PLoS One;12(10):e0184685, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Manganese is an essential element required by cyanobacteria, as it is an essential part of the oxygen-evolving center of photosystem II. In the presence of atmospheric oxygen, manganese is present as manganese oxides, which have low solubility and consequently provide low bioavailability. It is unknown if cyanobacteria are able to utilize these manganese sources, and what mechanisms may be employed to do so. Recent evidence suggests that type IV pili in non-photosynthetic bacteria facilitate electron donation to extracellular electron acceptors, thereby enabling metal acquisition. Our present study investigates whether PilA1 (major pilin protein of type IV pili) enables the cyanobacterium Synechocystis PCC 6808 to access to Mn from manganese oxides. We present physiological and spectroscopic data, which indicate that the presence of PilA1 enhances the ability of cyanobacteria to grow on manganese oxides. These observations suggest a role of PilA1-containing pili in cyanobacterial manganese acquisition.
[Mh] Termos MeSH primário: Cianobactérias/genética
Proteínas de Fímbrias/genética
Fímbrias Bacterianas/metabolismo
Manganês/metabolismo
[Mh] Termos MeSH secundário: Cianobactérias/crescimento & desenvolvimento
Cianobactérias/metabolismo
Proteínas de Fímbrias/metabolismo
Fímbrias Bacterianas/genética
Compostos de Manganês/metabolismo
Óxidos/metabolismo
Oxigênio/metabolismo
Complexo de Proteína do Fotossistema II/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); 0 (Photosystem II Protein Complex); 147680-16-8 (Fimbriae Proteins); 42Z2K6ZL8P (Manganese); 64J2OA7MH3 (manganese oxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184685


  8 / 3018 MEDLINE  
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[PMID]:28820989
[Au] Autor:Guo X; Wang Y; Wang D
[Ad] Endereço:College of Environmental Science and Engineering, Beijing Key Lab for Source Control Technology of Water Pollution, Beijing Forestry University, Beijing 100083, China.
[Ti] Título:Permanganate/bisulfite (PM/BS) conditioning-horizontal electro-dewatering (HED) of activated sludge: Effect of reactive Mn(III) species.
[So] Source:Water Res;124:584-594, 2017 Nov 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel activated sludge (AS) conditioning method through permanganate/bisulfate (PM/BS) process was proposed. The method involved a new conditioner of reactive Mn(III) intermediate. Moreover, a Mn(III) conditioning-horizontal electro-dewatering (Mn(III) C-HED) process was established to improve AS dewatering performance. Underlying mechanisms were unraveled by investigating changes in physicochemical characteristics, scanning electron microscope (SEM) morphology, and transformation of water and organic matters. The optimum dewatering conditions for Mn(III) C-HED process with the final water content of 86.94% were determined as the combination of KMnO 0.01 mol/L AS and NaHSO 0.05 mol/L AS at 20 V for 120 min. Results showed that Mn(III) C-HED process effectively reduced free water and bound water with the corresponding removal ratios of 51.68% and 87.62% at the anode-side as well as 36.55% and 85.08% at the cathode-side, respectively. During the PM/BS process, the produced Mn(III), Mn , and MnO exerted chemical and physical effects on AS conditioning and dewatering. Mn(III) disintegrated extracellular polymeric substances (EPS) fractions and cells in AS, as well as induced partial bound water release. Additionally, flocculation effect induced by Mn and MnO skeleton building also benefited AS dewatering. AS cells were further disrupted under the effect of a horizontal electric field. Accordingly, EPS within the AS matrix was solubilized, tightly bound (TB)-EPS or loosely bound (LB)-EPS was converted to their corresponding outer EPS fractions, and AS dewaterability improved. Additionally, changes in pH and temperature at HED stage damaged the AS cells and changed the floc properties, thereby leading to easy separation of liquid and AS particles.
[Mh] Termos MeSH primário: Compostos de Manganês
Óxidos
Esgotos
Sulfitos
[Mh] Termos MeSH secundário: Floculação
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); 0 (Sewage); 0 (Sulfites); 059QF0KO0R (Water); 14333-13-2 (permanganic acid); OJ9787WBLU (hydrogen sulfite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


  9 / 3018 MEDLINE  
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[PMID]:28802174
[Au] Autor:Gupta VK; Fakhri A; Agarwal S; Ahmadi E; Nejad PA
[Ad] Endereço:Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa. Electronic address: vinodfcy@gmail.com.
[Ti] Título:Synthesis and characterization of MnO /NiO nanocomposites for photocatalysis of tetracycline antibiotic and modification with guanidine for carriers of Caffeic acid phenethyl ester-an anticancer drug.
[So] Source:J Photochem Photobiol B;174:235-242, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present studies, modified NiO nanoparticles and MnO /NiO nanocomposites with guanidine were synthesized by anchoring method for carriers of anticancer drug "Caffeic acid phenethyl ester". The prepared nanocomposites were characterized by using Scanning Electron Microscopy, Raman and Fourier transform infrared spectroscopy, X-ray diffraction, Vibrating sample magnetometer. The results from XRD indicated that the crystalline size of NiO nanoparticles and MnO /NiO nanocomposites are 12 and 15nm, respectively. Saturation magnetization (Ms) for NiO NPs and MnO /NiO nanocomposites was to be 0.60, and 0.68emu/g indicating that these are superparamagnetic and ferromagnetic properties in nature. The prepared nanocomposites were evaluated as catalyst for degradation of antibiotics in photocatalysis process. Particularly, the MnO /NiO composite demonstrated the higher degradation rate (89.55%) of tetracycline antibiotic under UV light irradiation than the NiO (67.80%). Drug load on and release from nanopowders was investigated by using UV-Vis spectroscopy method. Time of drug loading was 100min and the drug release in 1-10h with 20-80% drug release were found, and then, it's applicable to in-vivo drug delivery. Therefore, the NiO nanoparticles and MnO /NiO nanocomposites are promising for targeted Caffeic acid phenethyl ester anticancer drug delivery applications. The anticancer drug loaded on guanidine-NiO and guanidine-MnO /NiO in high concentration has an antioxidant property.
[Mh] Termos MeSH primário: Ácidos Cafeicos/química
Guanidina/química
Compostos de Manganês/química
Nanocompostos/química
Níquel/química
Óxidos/química
Álcool Feniletílico/análogos & derivados
Fotólise
Tetraciclinas/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antineoplásicos/química
Catálise
Técnicas de Química Sintética
Portadores de Fármacos/síntese química
Portadores de Fármacos/química
Liberação Controlada de Fármacos
Depuradores de Radicais Livres/síntese química
Depuradores de Radicais Livres/química
Nanopartículas/química
Álcool Feniletílico/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Caffeic Acids); 0 (Drug Carriers); 0 (Free Radical Scavengers); 0 (Manganese Compounds); 0 (Oxides); 0 (Tetracyclines); 059QF0KO0R (Water); 64J2OA7MH3 (manganese oxide); 7OV03QG267 (Nickel); C3574QBZ3Y (nickel monoxide); G960R9S5SK (caffeic acid phenethyl ester); JU58VJ6Y3B (Guanidine); ML9LGA7468 (Phenylethyl Alcohol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


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[PMID]:28778520
[Au] Autor:Wang W; Li D; Ding X; Zhao Q; Chen J; Tian K; Qiu Y; Lu L
[Ad] Endereço:Department of Otolaryngology Head & Neck Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
[Ti] Título:N-Acetylcysteine protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels.
[So] Source:Toxicol Lett;279:77-86, 2017 Sep 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including nerves associated with the auditory system. Based on our studies of cochlear organotypic cultures, Mn exposure induces a significant loss of hair cells (HCs), auditory nerve fibers (ANFs) and spiral ganglion neurons (SGNs) in a concentration-dependent manner. Additionally, N-acetylcysteine (NAC), a glutathione (GSH) provider and a direct scavenger of reactive oxygen species (ROS), clearly decreases Mn-induced ROS accumulation, caspase-3 activation and TUNEL staining, which indicate increased cell survival. Based on these results, Mn exposure exerts ototoxic and neurotoxic effects on the auditory system. Furthermore, 20mM NAC may prevent 1mM Mn-induced hair cell loss and axonal degeneration, indicating that NAC could be a promising drug for clinical applications.
[Mh] Termos MeSH primário: Acetilcisteína/farmacologia
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Cloretos/toxicidade
Células Ciliadas Auditivas Internas/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Gânglio Espiral da Cóclea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Caspase 3/metabolismo
Citoproteção
Relação Dose-Resposta a Droga
Células Ciliadas Auditivas Internas/metabolismo
Células Ciliadas Auditivas Internas/patologia
Compostos de Manganês
Técnicas de Cultura de Órgãos
Ratos Sprague-Dawley
Gânglio Espiral da Cóclea/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Chlorides); 0 (Manganese Compounds); 0 (Neuroprotective Agents); 0 (Reactive Oxygen Species); EC 3.4.22.- (Casp3 protein, rat); EC 3.4.22.- (Caspase 3); QQE170PANO (manganese chloride); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE



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