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[PMID]: 28668464 [Au] Autor: Gill R; McCabe MJ; Rosenspire AJ [Ad] Endereço: Department of Immunology, Microbiology and Biochemistry, Wayne State University, Detroit, MI, United States. [Ti] Título: Low level exposure to inorganic mercury interferes with B cell receptor signaling in transitional type 1 B cells. [So] Source: Toxicol Appl Pharmacol;330:22-29, 2017 Sep 01. [Is] ISSN: 1096-0333 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Mercury (Hg) has been implicated as a factor contributing to autoimmune disease in animal models and humans. However the mechanism by which this occurs has remained elusive. Since the discovery of B cells it has been appreciated by immunologists that during the normal course of B cell development, some immature B cells must be generated that produce immunoglobulin reactive to self-antigens (auto-antibodies). However in the course of normal development, the vast majority of immature auto-reactive B cells are prevented from maturing by processes collectively known as tolerance. Autoimmune disease arises when these mechanisms of tolerance are disrupted. In the B cell compartment, it is firmly established that tolerance depends in part upon negative selection of self-reactive immature (transitional type 1) B cells. In these cells negative selection depends upon signals generated by the B Cell Receptor (BCR), in the sense that those T1 B cells who's BCRs most strongly bind to, and so generate the strongest signals to self-antigens are neutralized. In this report we have utilized multicolor phosphoflow cytometry to show that in immature T1 B cells Hg attenuates signal generation by the BCR through mechanisms that may involve Lyn, a key tyrosine kinase in the BCR signal transduction pathway. We suggest that exposure to low, environmentally relevant levels of Hg, disrupts tolerance by interfering with BCR signaling in immature B cells, potentially leading to the appearance of mature auto-reactive B cells which have the ability to contribute to auto-immune disease. [Mh] Termos MeSH primário: Linfócitos B/metabolismo Compostos de Mercúrio/toxicidade Receptores de Antígenos de Linfócitos B/efeitos dos fármacos Receptores de Antígenos de Linfócitos B/metabolismo Transdução de Sinais/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Linfócitos B/efeitos dos fármacos Linhagem Celular Membrana Celular/efeitos dos fármacos Membrana Celular/metabolismo Feminino Imunoglobulinas/metabolismo Imuno-Histoquímica Linfócitos/efeitos dos fármacos Sistema de Sinalização das MAP Quinases/efeitos dos fármacos Camundongos Camundongos Endogâmicos BALB C Baço/citologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Immunoglobulins); 0 (Mercury Compounds); 0 (Receptors, Antigen, B-Cell) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170824 [Lr] Data última revisão: 170824 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170703 [St] Status: MEDLINE

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[PMID]: 28641222 [Au] Autor: Tang H; Duan Y; Zhu C; Cai T; Li C; Cai L [Ad] Endereço: Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education, School of Energy and Environment, Southeast University, Nanjing, Jiangsu 210096, China. [Ti] Título: Theoretical evaluation on selective adsorption characteristics of alkali metal-based sorbents for gaseous oxidized mercury. [So] Source: Chemosphere;184:711-719, 2017 Oct. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Alkali metal-based sorbents are potential for oxidized mercury (Hg ) selective adsorption but show hardly effect to elemental mercury (Hg ) in flue gas. Density functional theory (DFT) was employed to investigate the Hg and HgCl adsorption mechanism over alkali metal-based sorbents, including calcium oxide (CaO), magnesium oxide (MgO), potassium chloride (KCl) and sodium chloride (NaCl). Hg was found to weakly interact with CaO (001), MgO (001), KCl (001) and NaCl (001) surfaces while HgCl was effectively adsorbed on top-O and top-Cl sites. Charge transfer and bond population were calculated to discuss the covalency and ionicity of HgCl bonding with the adsorption sites. The partial density of states (PDOS) analysis manifests that HgCl strongly interacts with surface sites through the orbital hybridizations between Hg and top O or Cl. Frontier molecular orbital (FMO) energy and Mulliken electronegativity are introduced as the quantitative criteria to evaluate the reactivity of mercury species and alkali metal-based sorbents. HgCl is identified as a Lewis acid and more reactive than Hg . The Lewis basicity of the four alkali metal-based sorbents is predicted as the increasing order: NaCl < MgO < KCl < CaO, in consistence with the trend of HgCl adsorption energies. [Mh] Termos MeSH primário: Mercúrio/química Metais Alcalinos/química Modelos Químicos [Mh] Termos MeSH secundário: Adsorção Compostos de Cálcio Gases Óxido de Magnésio Cloreto de Mercúrio Compostos de Mercúrio Óxidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Calcium Compounds); 0 (Gases); 0 (Mercury Compounds); 0 (Metals, Alkali); 0 (Oxides); 3A3U0GI71G (Magnesium Oxide); 53GH7MZT1R (Mercuric Chloride); C7X2M0VVNH (lime); FXS1BY2PGL (Mercury); IY191986AO (mercuric oxide) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170623 [St] Status: MEDLINE

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[PMID]: 28571847 [Au] Autor: Balland-Bolou-Bi C; Turc B; Alphonse V; Bousserrhine N [Ad] Endereço: Université Paris-Est Créteil Val de Marne, Institute of Ecology and Environmental Sciences of Paris (UMR 7618), 61 avenue du Général De Gaulle, 94010 Créteil cedex, France. Electronic address: Clarisse.bolou-bi@u-pec.fr. [Ti] Título: Impact of microbial communities from tropical soils on the mobilization of trace metals during dissolution of cinnabar ore. [So] Source: J Environ Sci (China);56:122-130, 2017 Jun. [Is] ISSN: 1001-0742 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Biodissolution experiments on cinnabar ore (mercury sulphide and other sulphide minerals, such as pyrite) were performed with microorganisms extracted directly from soil. These experiments were carried out in closed systems under aerobic and anaerobic conditions with 2 different soils sampled in French Guyana. The two main objectives of this study were (1) to quantify the ability of microorganisms to mobilize metals (Fe, Al, Hg) during the dissolution of cinnabar ore, and (2) to identify the links between the type and chemical properties of soils, environmental parameters such as season and the strategies developed by indigenous microorganisms extracted from tropical natural soils to mobilize metals. Results indicate that microbial communities extracted directly from various soils are able to (1) survive in the presence of cinnabar ore, as indicated by consumption of carbon sources and, (2) leach Hg from cinnabar in oxic and anoxic dissolution experiments via the acidification of the medium and the production of low molecular mass organic acids (LMMOAs). The dissolution rate of cinnabar in aerobic conditions with microbial communities ranged from 4.8×10 to 2.6×10 µmol/m /day and was independent of the metabolites released by the microorganisms. In addition, these results suggest an indirect action by the microorganisms in the cinnabar dissolution. Additionally, because iron is a key element in the dynamics of Hg, microbes were stimulated by the presence of this metal, and microbes released LMMOAs that leached iron from iron-bearing minerals, such as pyrite and oxy-hydroxide of iron, in the mixed cinnabar ore. [Mh] Termos MeSH primário: Monitoramento Ambiental Compostos de Mercúrio Metais/toxicidade Microbiologia do Solo Poluentes do Solo/toxicidade [Mh] Termos MeSH secundário: Clima Tropical [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Mercury Compounds); 0 (Metals); 0 (Soil Pollutants); ZI0T668SF1 (cinnabar) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170630 [Lr] Data última revisão: 170630 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170603 [St] Status: MEDLINE

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[PMID]: 28536007 [Au] Autor: Zhang BB; Li WK; Hou WY; Luo Y; Shi JZ; Li C; Wei LX; Liu J [Ad] Endereço: Key Lab for Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China. [Ti] Título: Zuotai and HgS differ from HgCl and methyl mercury in Hg accumulation and toxicity in weanling and aged rats. [So] Source: Toxicol Appl Pharmacol;331:76-84, 2017 Sep 15. [Is] ISSN: 1096-0333 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Mercury sulfides are used in Ayurvedic medicines, Tibetan medicines, and Chinese medicines for thousands of years and are still used today. Cinnabar (α-HgS) and metacinnabar (ß-HgS) are different from mercury chloride (HgCl ) and methylmercury (MeHg) in their disposition and toxicity. Whether such scenario applies to weanling and aged animals is not known. To address this question, weanling (21d) and aged (450d) rats were orally given Zuotai (54% ß-HgS, 30mg/kg), HgS (α-HgS, 30mg/kg), HgCl (34.6mg/kg), or MeHg (MeHgCl, 3.2mg/kg) for 7days. Accumulation of Hg in kidney and liver, and the toxicity-sensitive gene expressions were examined. Animal body weight gain was decreased by HgCl and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. HgCl and MeHg produced dramatic tissue Hg accumulation, increased kidney (kim-1 and Ngal) and liver (Ho-1) injury-sensitive gene expressions, but such changes are absent or mild after Zuotai and HgS. Aged rats were more susceptible than weanling rats to Hg toxicity. To examine roles of transporters in Hg accumulation, transporter gene expressions were examined. The expression of renal uptake transporters Oat1, Oct2, and Oatp4c1 and hepatic Oatp2 was decreased, while the expression of renal efflux transporter Mrp2, Mrp4 and Mdr1b was increased following HgCl and MeHg, but unaffected by Zuotai and HgS. Thus, Zuotai and HgS differ from HgCl and MeHg in producing tissue Hg accumulation and toxicity, and aged rats are more susceptible than weanling rats. Transporter expression could be adaptive means to reduce tissue Hg burden. [Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos Medicamentos de Ervas Chinesas/toxicidade Cloreto de Mercúrio/toxicidade Compostos de Mercúrio/toxicidade Compostos de Metilmercúrio/toxicidade [Mh] Termos MeSH secundário: Administração Oral Envelhecimento/metabolismo Animais Animais Recém-Nascidos Medicamentos de Ervas Chinesas/administração & dosagem Medicamentos de Ervas Chinesas/metabolismo Cloreto de Mercúrio/administração & dosagem Cloreto de Mercúrio/metabolismo Mercúrio/administração & dosagem Mercúrio/metabolismo Mercúrio/toxicidade Compostos de Mercúrio/administração & dosagem Compostos de Mercúrio/metabolismo Compostos de Metilmercúrio/administração & dosagem Compostos de Metilmercúrio/metabolismo Ratos Ratos Sprague-Dawley Desmame [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drugs, Chinese Herbal); 0 (Mercury Compounds); 0 (Methylmercury Compounds); 0 (zuotai); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170904 [Lr] Data última revisão: 170904 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170525 [St] Status: MEDLINE

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[PMID]: 28484136 [Au] Autor: Watanabe T; Hayashi T; Matsuda R; Akiyama H; Teshima R [Ad] Endereço: National Institute of Health Sciences. [Ti] Título: Surveillance of Total Mercury and Methylmercury Concentrations in Retail Fish. [So] Source: Shokuhin Eiseigaku Zasshi;58(2):80-85, 2017. [Is] ISSN: 1882-1006 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Most fish samples contain methylmercury, that the concentrations very greatly according to the fish species. To avoid the adverse health effects of methylmercury while retaining the benefits provided by fish consumption, it is important to select suitable fish species and to control the amount of the fish intake. We surveyed the concentrations of total mercury and methylmercury in 210 retail fish samples classified into 19 fish species by using validated analytical methods. The results of this survey were as follows. The total mercury and methylmercury concentrations were higher than 1 mg/kg in some samples of swordfish and bluefin tuna, which are large predatory fish species. In bluefin tuna and yellowtail, total mercury and methylmercury concentrations in farm-raised fish were lower than those in natural fish. There was a positive correlation between total mercury concentration and methylmercury concentration. Our results indicate that a cut-off value of 0.3 mg/kg total mercury in the screening of fish samples would increase the effectiveness of inspection. [Mh] Termos MeSH primário: Produtos Pesqueiros/análise Peixes/metabolismo Análise de Alimentos/métodos Compostos de Mercúrio/análise Compostos de Metilmercúrio/análise [Mh] Termos MeSH secundário: Animais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Mercury Compounds); 0 (Methylmercury Compounds) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170510 [St] Status: MEDLINE [do] DOI: 10.3358/shokueishi.58.80

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[PMID]: 28381770 [Au] Autor: Charanyaa S; Belur PD; Regupathi I [Ad] Endereço: Department of Chemical Engineering, National Institute of Technology Karnataka. [Ti] Título: A New Strategy to Refine Crude Indian Sardine Oil. [So] Source: J Oleo Sci;66(5):425-434, 2017 May 01. [Is] ISSN: 1347-3352 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: Current work aims to develop a refining process for removing phospholipids, free fatty acids (FFA), and metal ions without affecting n-3 polyunsaturated fatty acid (n-3 PUFA) esters present in the crude Indian sardine oil. Sardine oil was subjected to degumming with various acids (orthophosphoric acid, acetic acid, and lactic acid), conventional and membrane assisted deacidification using various solvents (methanol, ethanol, propanol and butanol) and bleaching with bleaching agents (GAC, activated earth and bentonite) and all the process parameters were further optimized. Degumming with 5%(w/w) ortho phosphoric acid, two stage solvent extraction with methanol at 1:1 (w/w) in each stage and bleaching with 3% (w/w) activated charcoal loading, at 80ºC for 10 minutes resulted in the reduction of phospholipid content to 5.66 ppm from 612.66 ppm, FFA to 0.56% from 5.64% with the complete removal of iron and mercury. Under these conditions, the obtained bleached oil showed an enhancement of n-3 PUFA from 16.39 % (11.19 Eicosapentaenoic acid (EPA) + 5.20 Docosahexaenoic acid (DHA)) to 17.91 % (11.81 EPA + 6.1 DHA). Replacing conventional solvent extraction with membrane deacidification using microporous, hydrophobic polytetrafluoroethylene membrane (PTFE), resulted in a lesser solvent residue (0.25% (w/w)) in the deacidified oil. In view of lack of reports on refining of n-3 PUFA rich marine oils without concomitant loss of n-3 PUFA, this report is significant. [Mh] Termos MeSH primário: Ésteres/análise Ácidos Graxos Ômega-3/análise Óleos de Peixe/análise Óleos de Peixe/química [Mh] Termos MeSH secundário: Clareadores Carvão Vegetal Ácidos Graxos não Esterificados/isolamento & purificação Íons Compostos de Ferro/isolamento & purificação Compostos de Mercúrio/isolamento & purificação Fosfolipídeos/isolamento & purificação Ácidos Fosfóricos Politetrafluoretileno Solventes Temperatura Ambiente [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bleaching Agents); 0 (Esters); 0 (Fatty Acids, Nonesterified); 0 (Fatty Acids, Omega-3); 0 (Fish Oils); 0 (Ions); 0 (Iron Compounds); 0 (Mercury Compounds); 0 (Phospholipids); 0 (Phosphoric Acids); 0 (Solvents); 16291-96-6 (Charcoal); 9002-84-0 (Polytetrafluoroethylene); E4GA8884NN (phosphoric acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170407 [St] Status: MEDLINE [do] DOI: 10.5650/jos.ess16164

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[PMID]: 28379072 [Au] Autor: Branco V; Caito S; Farina M; Teixeira da Rocha J; Aschner M; Carvalho C [Ad] Endereço: a Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia , Universidade de Lisboa , Lisboa , Portugal. [Ti] Título: Biomarkers of mercury toxicity: Past, present, and future trends. [So] Source: J Toxicol Environ Health B Crit Rev;20(3):119-154, 2017. [Is] ISSN: 1521-6950 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial compounds (methylmercury through fish, mercury vapor from dental amalgams, and ethylmercury from vaccines), the need for more sensitive and refined tools to assess the effects and/or susceptibility to adverse metal-mediated health risks remains. Traditional biomarkers, such as hair or blood Hg levels, are practical and provide a reliable measure of exposure, but given intra-population variability, it is difficult to establish accurate cause-effect relationships. It is therefore important to identify and validate biomarkers that are predictive of early adverse effects prior to adverse health outcomes becoming irreversible. This review describes the predominant biomarkers used by toxicologists and epidemiologists to evaluate exposure, effect and susceptibility to Hg compounds, weighing on their advantages and disadvantages. Most importantly, and in light of recent findings on the molecular mechanisms underlying Hg-mediated toxicity, potential novel biomarkers that might be predictive of toxic effect are presented, and the applicability of these parameters in risk assessment is examined. [Mh] Termos MeSH primário: Exposição Ambiental/efeitos adversos Poluentes Ambientais/toxicidade Compostos de Mercúrio/toxicidade Mercúrio/toxicidade Compostos de Metilmercúrio/toxicidade [Mh] Termos MeSH secundário: Animais Biomarcadores/análise Seres Humanos Medição de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Biomarkers); 0 (Environmental Pollutants); 0 (Mercury Compounds); 0 (Methylmercury Compounds); FXS1BY2PGL (Mercury) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170616 [Lr] Data última revisão: 170616 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170406 [St] Status: MEDLINE [do] DOI: 10.1080/10937404.2017.1289834

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[PMID]: 28339347 [Au] Autor: Bridges CC; Zalups RK [Ad] Endereço: a Mercer University School of Medicine , Division of Basic Medical Sciences , Macon , Georgia , USA. [Ti] Título: The aging kidney and the nephrotoxic effects of mercury. [So] Source: J Toxicol Environ Health B Crit Rev;20(2):55-80, 2017. [Is] ISSN: 1521-6950 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Owing to advances in modern medicine, life expectancies are lengthening and leading to an increase in the population of older individuals. The aging process leads to significant alterations in many organ systems, with the kidney being particularly susceptible to age-related changes. Within the kidney, aging leads to ultrastructural changes such as glomerular and tubular hypertrophy, glomerulosclerosis, and tubulointerstitial fibrosis, which may compromise renal plasma flow (RPF) and glomerular filtration rate (GFR). These alterations may reduce the functional reserve of the kidneys, making them more susceptible to pathological events when challenged or stressed, such as following exposure to nephrotoxicants. An important and prevalent environmental toxicant that induces nephrotoxic effects is mercury (Hg). Since exposure of normal kidneys to mercuric ions might induce glomerular and tubular injury, aged kidneys, which may not be functioning at full capacity, may be more sensitive to the effects of Hg than normal kidneys. Age-related renal changes and the effects of Hg in the kidney have been characterized separately. However, little is known regarding the influence of nephrotoxicants, such as Hg, on aged kidneys. The purpose of this review was to summarize known findings related to exposure of aged and diseased kidneys to the environmentally relevant nephrotoxicant Hg. [Mh] Termos MeSH primário: Envelhecimento Poluentes Ambientais/toxicidade Rim/efeitos dos fármacos Compostos de Mercúrio/toxicidade Mercúrio/toxicidade Compostos Organomercúricos/toxicidade [Mh] Termos MeSH secundário: Animais Seres Humanos Rim/fisiologia Rim/fisiopatologia Nefropatias/induzido quimicamente Camundongos Ratos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Environmental Pollutants); 0 (Mercury Compounds); 0 (Organomercury Compounds); FXS1BY2PGL (Mercury) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171011 [Lr] Data última revisão: 171011 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170325 [St] Status: MEDLINE [do] DOI: 10.1080/10937404.2016.1243501

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[PMID]: 28319158 [Au] Autor: Gutiérrez-de-Juan V; López de Davalillo S; Fernández-Ramos D; Barbier-Torres L; Zubiete-Franco I; Fernández-Tussy P; Simon J; Lopitz-Otsoa F; de Las Heras J; Iruzubieta P; Arias-Loste MT; Villa E; Crespo J; Andrade R; Lucena MI; Varela-Rey M; Lu SC; Mato JM; Delgado TC; Martínez-Chantar ML [Ad] Endereço: CIC bioGUNE (Center for Cooperative Research in Biosciences), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Bizkaia, Spain. [Ti] Título: A morphological method for ammonia detection in liver. [So] Source: PLoS One;12(3):e0173914, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common event in acute liver injury/failure and chronic liver disease. Even though hepatic ammonia levels are potential predictive factors of patient outcome, easy and inexpensive methods aiming at the detection of liver ammonia accumulation in the clinical setting remain unavailable. Thus, herein we have developed a morphological method, based on the utilization of Nessler´s reagent, to accurately and precisely detect the accumulation of ammonia in biological tissue. We have validated our method against a commercially available kit in mouse tissue samples and, by using this modified method, we have confirmed the hepatic accumulation of ammonia in clinical and animal models of acute and chronic advanced liver injury as well as in the progression of fatty liver disease. Overall, we propose a morphological method for ammonia detection in liver that correlates well with the degree of liver disease severity and therefore can be potentially used to predict patient outcome. [Mh] Termos MeSH primário: Amônia/metabolismo Técnicas Citológicas/métodos Iodetos/metabolismo Fígado/citologia Fígado/metabolismo Compostos de Mercúrio/metabolismo [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Animais Pré-Escolar Seres Humanos Fígado/lesões Fígado/patologia Masculino Camundongos Meia-Idade Hepatopatia Gordurosa não Alcoólica/metabolismo Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Iodides); 0 (Mercury Compounds); 7664-41-7 (Ammonia); 7N83S6IU0F (potassium tetraiodomercurate) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170321 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0173914

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[PMID]: 28273537 [Au] Autor: Baldi F; Gallo M; Daniele S; Battistel D; Faleri C; Kodre A; Arcon I [Ad] Endereço: Dipartimento di Scienze Molecolari e Nanosistemi, University Cà Foscari Venezia, Via Torino 155, 30172, Mestre Venezia, Italy. Electronic address: baldi@unive.it. [Ti] Título: An extracellular polymeric substance quickly chelates mercury(II) with N-heterocyclic groups. [So] Source: Chemosphere;176:296-304, 2017 Jun. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A strain of Klebsiella oxytoca DSM 29614 is grown on sodium citrate in the presence of 50 mg l of Hg as Hg(NO ) . During growth, the strain produces an extracellular polymeric substance (EPS), constituted by a mixture of proteins and a specific exopolysaccharide. The protein components, derived from the outer membrane of cells, are co-extracted with the extracellular exopolysaccharide using ethanol. The extracted EPS contains 7.5% of Hg (total amount). This indicates that EPS is an excellent material for the biosorption of Hg , through chemical complexation with the EPS components. The binding capacity of these species towards Hg is studied by cyclic voltammetry, and Hg L -edge XANES and EXAFS spectroscopy. The results found indicate that Hg is mainly bound to the nitrogen of the imidazole ring or other N-heterocycle compounds. The hydroxyl moities of sugars and/or the carboxyl groups of two glucuronic acids in the polysaccharide can also play an important role in sequestring Hg ions. However, N-heterocyclic groups of proteins bind Hg faster than hydroxyl and carboxyl groups of the polysaccharide. [Mh] Termos MeSH primário: Quelantes/química Compostos Heterocíclicos/química Klebsiella oxytoca/metabolismo Compostos de Mercúrio/análise Nitratos/análise Polissacarídeos Bacterianos/química Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: Proteínas de Bactérias/química Quelantes/metabolismo Klebsiella oxytoca/ultraestrutura Compostos de Mercúrio/metabolismo Modelos Teóricos Nitratos/metabolismo Polissacarídeos Bacterianos/metabolismo Ligação Proteica Poluentes Químicos da Água/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bacterial Proteins); 0 (Chelating Agents); 0 (Heterocyclic Compounds); 0 (Mercury Compounds); 0 (Nitrates); 0 (Polysaccharides, Bacterial); 0 (Water Pollutants, Chemical); 24670-15-3 (mercury nitrate) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170517 [Lr] Data última revisão: 170517 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170309 [St] Status: MEDLINE

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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