[PMID]: | 28536007 |
[Au] Autor: | Zhang BB; Li WK; Hou WY; Luo Y; Shi JZ; Li C; Wei LX; Liu J |
[Ad] Endereço: | Key Lab for Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China. |
[Ti] Título: | Zuotai and HgS differ from HgCl and methyl mercury in Hg accumulation and toxicity in weanling and aged rats. |
[So] Source: | Toxicol Appl Pharmacol;331:76-84, 2017 Sep 15. |
[Is] ISSN: | 1096-0333 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Mercury sulfides are used in Ayurvedic medicines, Tibetan medicines, and Chinese medicines for thousands of years and are still used today. Cinnabar (α-HgS) and metacinnabar (ß-HgS) are different from mercury chloride (HgCl ) and methylmercury (MeHg) in their disposition and toxicity. Whether such scenario applies to weanling and aged animals is not known. To address this question, weanling (21d) and aged (450d) rats were orally given Zuotai (54% ß-HgS, 30mg/kg), HgS (α-HgS, 30mg/kg), HgCl (34.6mg/kg), or MeHg (MeHgCl, 3.2mg/kg) for 7days. Accumulation of Hg in kidney and liver, and the toxicity-sensitive gene expressions were examined. Animal body weight gain was decreased by HgCl and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. HgCl and MeHg produced dramatic tissue Hg accumulation, increased kidney (kim-1 and Ngal) and liver (Ho-1) injury-sensitive gene expressions, but such changes are absent or mild after Zuotai and HgS. Aged rats were more susceptible than weanling rats to Hg toxicity. To examine roles of transporters in Hg accumulation, transporter gene expressions were examined. The expression of renal uptake transporters Oat1, Oct2, and Oatp4c1 and hepatic Oatp2 was decreased, while the expression of renal efflux transporter Mrp2, Mrp4 and Mdr1b was increased following HgCl and MeHg, but unaffected by Zuotai and HgS. Thus, Zuotai and HgS differ from HgCl and MeHg in producing tissue Hg accumulation and toxicity, and aged rats are more susceptible than weanling rats. Transporter expression could be adaptive means to reduce tissue Hg burden. |
[Mh] Termos MeSH primário: |
Envelhecimento/efeitos dos fármacos Medicamentos de Ervas Chinesas/toxicidade Cloreto de Mercúrio/toxicidade Compostos de Mercúrio/toxicidade Compostos de Metilmercúrio/toxicidade
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[Mh] Termos MeSH secundário: |
Administração Oral Envelhecimento/metabolismo Animais Animais Recém-Nascidos Medicamentos de Ervas Chinesas/administração & dosagem Medicamentos de Ervas Chinesas/metabolismo Cloreto de Mercúrio/administração & dosagem Cloreto de Mercúrio/metabolismo Mercúrio/administração & dosagem Mercúrio/metabolismo Mercúrio/toxicidade Compostos de Mercúrio/administração & dosagem Compostos de Mercúrio/metabolismo Compostos de Metilmercúrio/administração & dosagem Compostos de Metilmercúrio/metabolismo Ratos Ratos Sprague-Dawley Desmame
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Drugs, Chinese Herbal); 0 (Mercury Compounds); 0 (Methylmercury Compounds); 0 (zuotai); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury) |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170904 |
[Lr] Data última revisão:
| 170904 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170525 |
[St] Status: | MEDLINE |
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