Base de dados : MEDLINE
Pesquisa : D01.578 [Categoria DeCS]
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  1 / 19192 MEDLINE  
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[PMID]:28985540
[Au] Autor:Wang YS; Dai JG; Wang L; Tsang DCW; Poon CS
[Ad] Endereço:Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
[Ti] Título:Influence of lead on stabilization/solidification by ordinary Portland cement and magnesium phosphate cement.
[So] Source:Chemosphere;190:90-96, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inorganic binder-based stabilization/solidification (S/S) of Pb-contaminated soil is a commonly used remediation approach. This paper investigates the influences of soluble Pb species on the hydration process of two types of inorganic binders: ordinary Portland cement (OPC) and magnesium potassium phosphate cement (MKPC). The environmental leachability, compressive strength, and setting time of the cement products are assessed as the primary performance indicators. The mechanisms of Pb involved in the hydration process are analyzed through X-ray diffraction (XRD), hydration heat evolution, and thermogravimetric analyses. Results show that the presence of Pb imposes adverse impact on the compressive strength (decreased by 30.4%) and the final setting time (prolonged by 334.7%) of OPC, but it exerts much less influence on those of MKPC. The reduced strength and delayed setting are attributed to the retarded hydration reaction rate of OPC during the induction period. These results suggest that the OPC-based S/S of soluble Pb mainly depends on physical encapsulation by calcium-silicate-hydrate (CSH) gels. In contrast, in case of MKPC-based S/S process, chemical stabilization with residual phosphate (pyromorphite and lead phosphate precipitation) and physical fixation of cementitious struvite-K are the major mechanisms. Therefore, MKPC is a more efficient and chemically stable inorganic binder for the Pb S/S process.
[Mh] Termos MeSH primário: Materiais de Construção
Chumbo/química
Compostos de Magnésio/química
Fosfatos/química
Poluentes do Solo/química
[Mh] Termos MeSH secundário: Compostos de Cálcio
Géis/química
Minerais/química
Compostos de Potássio/química
Silicatos
Poluentes Químicos da Água/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Gels); 0 (Magnesium Compounds); 0 (Minerals); 0 (Phosphates); 0 (Potassium Compounds); 0 (Silicates); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 12190-77-1 (pyromorphite); 2P299V784P (Lead); 453COF7817 (magnesium phosphate); 62I1T06190 (lead phosphate); B7862WZ632 (potassium phosphate); S4255P4G5M (calcium silicate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  2 / 19192 MEDLINE  
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[PMID]:28521524
[Au] Autor:Roggatz CC; González-Wangüemert M; Pereira H; Vizetto-Duarte C; Rodrigues MJ; Barreira L; da Silva MM; Varela J; Custódio L
[Ad] Endereço:a Faculty of Sciences and Technology, Center of Marine Sciences (CCMAR) , University of Algarve , Faro , Portugal.
[Ti] Título:A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain).
[So] Source:Nat Prod Res;32(1):116-120, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work reports for the first time the nutritional profile, including proximate chemical composition, amino acids, fatty acids and minerals of Parastichopus regalis from the Mediterranean Sea (SE Spain). The studied species had a high moisture content, moderate protein and low lipid levels. The most abundant amino acids were glutamic acid, arginine and tyrosine. Polyunsaturated fatty acids, especially arachidonic acid, dominated the fatty acid profile. Iron, sodium, calcium and zinc were the most abundant mine rals. In general, P. regalis has a balanced nutritional quality suitable for human consumption.
[Mh] Termos MeSH primário: Aminoácidos/análise
Ácidos Graxos/análise
Minerais/análise
Valor Nutritivo
Pepinos-do-Mar/química
[Mh] Termos MeSH secundário: Animais
Ácidos Graxos Insaturados/análise
Mar Mediterrâneo
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Fatty Acids); 0 (Fatty Acids, Unsaturated); 0 (Minerals)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1331224


  3 / 19192 MEDLINE  
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[PMID]:29268104
[Au] Autor:Geng C; Bergheaud V; Garnier P; Zhu YG; Haudin CS
[Ad] Endereço:UMR ECOSYS, INRA, AgroParisTech, Université Paris-Saclay, 78850, Thiverval-Grignon, France; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, China.
[Ti] Título:Impact of sludge treatments on the extractability and fate of acetyl sulfamethoxazole residues in amended soils.
[So] Source:Chemosphere;194:828-836, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sludge recycled in agriculture may bring antibiotics into cropped soils. The nature, total amount, and availability of the antibiotics in soil partly depend on the sludge treatments. Our paper compares the fate of N-acetyl sulfamethoxazole (AC-SMX) residues between soils incubated with the same sludge but submitted to different processes before being added in soil. The fate of C-AC-SMX residues was studied in mixtures of soil and sludges at different treatment levels: 1) activated and 2) centrifuged sludges, both enriched with C-AC-SMX, and 3) limed and 4) heat-dried sludges obtained by treating the previously contaminated centrifuged sludge. The evolution of the extractability of C residues (CaCl , methanol) and their mineralization were followed during 119 days. More than 80% of the initial C-activity was no longer extractable after 14 days, except in soil with limed sludge. Liming and drying the centrifuged sludge decreased the mineralized C fraction from 5.7-6.4% to 1.2-1.8% and consequently, the corresponding soils contained more C residues after 119 days. Although C residues were more CaCl -extractable in soil with limed sludge, they seemed to be poorly bioavailable for biodegradation. For all solid sludges, the mineralization rate of C-AC-SMX residues was strongly correlated to that of sludge organic carbon, with a coefficient three times lower for the limed and dried sludges than for the centrifuged sludge after 14 days.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Esgotos/química
Poluentes do Solo/química
Solo/química
Sulfametoxazol/química
[Mh] Termos MeSH secundário: Agricultura/métodos
Compostos de Cálcio
Radioisótopos de Carbono
Dessecação
Recuperação e Remediação Ambiental/métodos
Minerais
Óxidos
Esgotos/microbiologia
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Calcium Compounds); 0 (Carbon Radioisotopes); 0 (Minerals); 0 (Oxides); 0 (Sewage); 0 (Soil); 0 (Soil Pollutants); C7X2M0VVNH (lime); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  4 / 19192 MEDLINE  
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[PMID]:29247935
[Au] Autor:Das N; Das A; Sarma KP; Kumar M
[Ad] Endereço:Department of Environmental Science, Tezpur University, Napaam 784028, Assam, India.
[Ti] Título:Provenance, prevalence and health perspective of co-occurrences of arsenic, fluoride and uranium in the aquifers of the Brahmaputra River floodplain.
[So] Source:Chemosphere;194:755-772, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present work focuses on understanding the provenance, prevalence and health perspective of As and F along with possible co-occurrence of uranium (U) in the aquifers of the Brahmaputra floodplains (BFP), India. Groundwater (n = 164) and sediment samples (n = 5) were obtained from the upper, middle and lower BFP. Energy dispersive spectroscopy (EDX) revealed the presence of As, U and Fe in the sediment matrix. Regression analysis showed a weaker relationship between As and F co-occurrence. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) suggested reductive dissolution of Fe (hydr)oxides responsible for As release in the BFP, especially in the upper and lower BFP. Bicarbonate appeared to compete with As oxyanions for adsorption on positively charged surfaces leading to As release. Arsenic desorption in presence of PO , F and HCO at elevated pH appeared greatest in the upper BFP, suggesting the highest potential for co-occurrence. Co-occurrence, were mainly in isolated aquifers of the upper BFP owing to desorption of adsorbed As and F from Fe (hydr)oxides at higher pH. Weathering and dissolution of clay minerals in the upper BFP, and competitive desorption in presence of HCO and PO in the middle and lower BFP, respectively, explain variabilities in F release. Amorphous Fe (hydr)oxides like ferrihydrite act as sinks of U. Concentrations of As and F will likely increase in the future as projected from the saturated levels of goethite and ferrihydrite. Hazard indices (HI) revealed that children (3-8 years) were at greater health risk than adults.
[Mh] Termos MeSH primário: Arsênico/análise
Fluoretos/análise
Água Subterrânea/química
Rios/química
Urânio/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Adsorção
Adulto
Criança
Pré-Escolar
Análise por Conglomerados
Compostos Férricos/análise
Seres Humanos
Índia
Compostos de Ferro/análise
Minerais/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Iron Compounds); 0 (Minerals); 0 (Water Pollutants, Chemical); 1310-14-1 (goethite); 4OC371KSTK (Uranium); 87PZU03K0K (ferric oxyhydroxide); N712M78A8G (Arsenic); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  5 / 19192 MEDLINE  
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[PMID]:29028600
[Au] Autor:H Valido I; Padoan E; Moreno T; Querol X; Font O; Amato F
[Ad] Endereço:Institute of Environmental Assessment and Water Research (IDÆA), Spanish National Research Council (CSIC), Barcelona, Spain. Electronic address: iris.henriquez@uab.cat.
[Ti] Título:Physico-chemical characterization of playground sand dust, inhalable and bioaccessible fractions.
[So] Source:Chemosphere;190:454-462, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dust is a mixture of natural and anthropogenic particles originated from multiple sources, which can represent an hazard for human health. Playgrounds are a site of particularly concern, due to sand dust ingestion by toddlers and inhalation. In this study, 37 sands used in public playgrounds in the city of Barcelona were physico-chemically characterized also in relation to routine maintenance activities such as disinfection and sand renewal. The analyzed sands show a felsic mineralogy dominated by Na-feldspar, quartz, and, to a lesser extent, K-feldspar, with minor amounts of clay minerals, carbonates and hematite. Particle fractions below 10, 2.5 and 1 µm represent, on average, 0.65%, 0.17% and 0.07% of bulk volume, respectively, although, due to the human grinding, these initial fractions increased every year by a 18%, 5% and 2% respectively. Disinfection of sands effectively reduced only the NH concentration, among inorganic species. The average metal content was anthropogenically enriched, with respect to the upper continental crust, only for Sb and As. Both elements show high spatial variation indicating local sources such as road traffic for Sb (contributing mostly to the total concentration), and industry for As (also contributing with highly bioaccessible Sb, Cu and Zn). A clear inverse relationship between total concentrations of some elements and their leachable (Sb) and bioaccessible (Sb and Cr) fractions is observed. The most bioaccessible elements were Ca > Ni > Cu > Sr > Cd > Pb, all above the 25% of the total concentration. Bioaccessibility was higher for the carbonate-bearing particles and for the anthropic emitted metals (>50% of Ba, Cu, K, Pb and Zn).
[Mh] Termos MeSH primário: Cidades
Poeira/análise
Monitoramento Ambiental/métodos
Parques Recreativos
Material Particulado/análise
[Mh] Termos MeSH secundário: Silicatos de Alumínio/análise
Exposição Ambiental/análise
Seres Humanos
Exposição por Inalação/análise
Metais/análise
Minerais/análise
Compostos de Potássio/análise
Dióxido de Silício/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Dust); 0 (Metals); 0 (Minerals); 0 (Particulate Matter); 0 (Potassium Compounds); 12168-80-8 (feldspar); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  6 / 19192 MEDLINE  
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[PMID]:29217505
[Au] Autor:Bould H; Newbegin C; Stewart A; Stein A; Fazel M
[Ad] Endereço:Department of Psychiatry, Warneford Hospital, Oxford, UK helen.bould@psych.ox.ac.uk.
[Ti] Título:Eating disorders in children and young people.
[So] Source:BMJ;359:j5245, 2017 12 07.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtornos da Alimentação e da Ingestão de Alimentos/diagnóstico
Transtornos da Alimentação e da Ingestão de Alimentos/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Comorbidade
Diagnóstico Diferencial
Suplementos Nutricionais
Gerenciamento Clínico
Transtornos da Alimentação e da Ingestão de Alimentos/complicações
Transtornos da Alimentação e da Ingestão de Alimentos/psicologia
Feminino
Seres Humanos
Masculino
Minerais/uso terapêutico
Psicoterapia/métodos
Psicotrópicos/uso terapêutico
Medição de Risco/métodos
Vitaminas/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 0 (Psychotropic Drugs); 0 (Vitamins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5245


  7 / 19192 MEDLINE  
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[PMID]:29381305
[Au] Autor:Beketova NA; Sokolnikov AA; Kodentsova VM; Pereverzeva OG; Vrzhesinskaya OA; Kosheleva OV; Gmoshinskaya MV
[Ti] Título:[The vitamin status of pregnant women in Moscow: effect of multivitamin-mineral supplements].
[So] Source:Vopr Pitan;85(5):77-85, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Examination of the vitamin status of 102 pregnant women (19-41 years old) from Moscow (gestational age 6-38 weeks) in winter and spring 2015 has been conducted. The lack of vitamin B2 (blood serum level of riboflavin <5 ng/ml), D (25(OH)D level <30 ng/ml) and ß-carotene (<20 mg/dL) occurred in 49-66% of pregnant women. The percentage of persons with reduced serum levels of vitamin B6 (<4.8 mg/l), folic acid (<3 mg/l), vitamin A (<30 mg/dL), and E (<0.8 mg/dl) was insignificant and amounted 6-8%. All of the women had an adequate supply with vitamins C (>0.4 mg/dL) and B12 (>150 ng/L). The frequency of the combined deficiency of two vitamins was 29%, of three vitamins - 21%, four - 10%, five - 5%. Only 8% of women were sufficiently supplied with all 8 studied vitamins and ß-carotene. A positive correlation (p<0.001) between the concentration of vitamin E and gestation term occurred. ß-Carotene blood serum level raised with increasing gestation term in women receiving multivitamin-mineral supplements (VMS) and directly correlated (p<0.05) with vitamin E serum level. In 63 women who were not taking VMS, blood serum level of vitamins A, D, C, B2, B6, B12, folic acid and ß-carotene was lower, and the frequency of inadequate supply, on the contrary, was significantly higher, compared to 39 women receiving VMS. Blood serum concentration of vitamins C, A, D, B6 and folic acid in women who were not taking VMS was significantly reduced (p<0.05) with increasing gestation term, whereas in women consuming VMS vitamin blood serum level was maintained at a constant level. The data obtained demonstrate advisability of VMS intake during pregnancy to maintain vitamin status of pregnant women at a satisfactory level and to reduce the risk of birth defects in infants.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Minerais/sangue
Gravidez/sangue
Fenômenos Fisiológicos da Nutrição Pré-Natal/fisiologia
Vitaminas/sangue
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 0 (Vitamins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


  8 / 19192 MEDLINE  
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[PMID]:29378109
[Au] Autor:Kodentsova VM; Pogozheva AV; Gromova OA; Shikh EV
[Ti] Título:[Vitamin-mineral supplements in nutrition of adults].
[So] Source:Vopr Pitan;84(6):141-50, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The diet of population consisting of natural products is quite adequate and even excessive of energy consumption, but is not able to meet fully the need of organism in a number of micronutrients. Due to lack of sun exposure and long presence indoors endogenous synthesis of vitamin D in the skin by ultraviolet radiation does not provide the body's need for this vitamin. Intake of vitaminmineral supplements (VMS) is appropriate because combined deficiency of vitamins and minerals takes place in population. Prophylactic doses (equal to physiological needs) provide a diet completeness and reduce the risk of vitamin deficiency and its consequences. The high incidence of combined deficiency of vitamins among population and the existence of vitamin interactions are the basis for the application of the multivitamins. The simultaneous intake of vitamins is more physiological, their combination is more effective than a separate or isolated destination of each of them. Efficacy of the VMS has been shown in the treatment and prevention of some diseases. The main requirements for the VMS are full list of vitamins and minerals, the lack of which is detected most frequently, in doses covering the needs of organism. For the health of the pregnant woman and her unborn child preference should be given for complexes, containing DHA and/or probiotics along with vitamins. The principles of the selection of the composition and vitamin doses in the VMS for using patients suffering from various pathologies should be based on data on the patient's sufficiency with vitamins, the understanding of the role of vitamin deficiency in the pathogenesis of the disease, as well as on the composition of the diet and its modifications.
[Mh] Termos MeSH primário: Deficiência de Vitaminas/dietoterapia
Suplementos Nutricionais
Ingestão de Alimentos
Minerais/uso terapêutico
Fenômenos Fisiológicos da Nutrição Pré-Natal
Vitaminas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Deficiência de Vitaminas/sangue
Feminino
Seres Humanos
Masculino
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Minerals); 0 (Vitamins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  9 / 19192 MEDLINE  
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[PMID]:29377658
[Au] Autor:Borovik TE; Guseva IM; Semenova NN; Zvonkova NG; Lukoyanova OL; Zakharova IN; Stepanova TN; Surzhik AV; Mozzhukhina LI; Rusova TV
[Ti] Título:Characteristics of the nutrition organization and nutrient consumption in toddlers' living in the Central Federal District, Russian Federation (Moscow, Ivanovo, Yaroslavl).
[So] Source:Vopr Pitan;85(6):86-94, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A multicenter cross-sectional study with the participation of 356 healthy children aged 1 to 3 years from the cities of the Central Federal District: Moscow (n=106), Ivanovo (n=126), Yaroslavl (n=124) has been carried out. Questionnaire method, the method of 24-hour diet recall for 3 days (2 weekdays and 1 weekend) and the method of diary recording of food intake were used. The average daily volumes of food were consistent with the recommended age norms only in 31.2% of the surveyed children; after 1 year of life children actively started to transfer to nutrition from the family table and only 51.7% of children continued to receive individually prepared for baby food. The recommended dietary allowances were inadequate in macro- and micronutrients: 48.6% of all children received excessive amounts of protein and fat, and 74.1% were less in carbohydrates. The consumption of vitamins D and A and minerals (calcium, iron and zinc) did not correspond to existing recommendations in the majority of cases: only 10-30% of the examined children received physiological norms of vitamins from food and 13-34% - some minerals and trace elements. These results indicate that the nutrition of young children living in the Central Federal District is imbalanced on daily caloric, macro- and micronutrient composition, does not fully meet the requirements of the balanced diet and needs serious optimization.
[Mh] Termos MeSH primário: Desenvolvimento Infantil/fisiologia
Fenômenos Fisiológicos da Nutrição Infantil/fisiologia
Ingestão de Alimentos/fisiologia
Ingestão de Energia/fisiologia
Fórmulas Infantis
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Pré-Escolar
Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/análise
Feminino
Seres Humanos
Lactente
Masculino
Minerais/administração & dosagem
Minerais/análise
Moscou
Vitamina A/administração & dosagem
Vitamina A/análise
Vitamina D/administração & dosagem
Vitamina D/análise
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Dietary Proteins); 0 (Minerals); 11103-57-4 (Vitamin A); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  10 / 19192 MEDLINE  
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[PMID]:29376310
[Au] Autor:Tyshko NV; Sadykova EO; Timonin AN; Shestakova SI; Trebukh MD; Pashorina VA
[Ti] Título:Modification of vitamin-mineral diet composition as a model of adaptive potential reducing in laboratory animals.
[So] Source:Vopr Pitan;85(6):64-71, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This publication presents the results of research that was aimed at elaboration of adaptive potential reducing model, intended for toxicological experiments. Two series of research (with a duration of 70 days each) were conducted on Wistar rats. In the 1st series five groups of animals received diets with 100, 75,50,25 and 0% of vitamins B1, B2, B3, B6 and minerals(Fe3+ and Mg2+); in the 2nd series four groups of animals received diets with 21.37, 9.94, 4.62, 2.15% of this vitamins and minerals. In the 1st series of studies the intervals of maximum, medium and minimum content of essential nutrients in the diet was established; in the 2nd series the range of the lowest possible concentrations of these elements that provided the lowest level of adaptive potential and not causing the pathology development was determined. The certain set of hematological, biochemical, immunological and other indicators were investigated, this article analyzes the results of zoometric studies, mortality of animals, as well as the results of antioxidant status (activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and malondialdehyde content in red blood cells) studies. Based on the evaluation of the data which were obtained in the 1st series, it follows that a dose reduction of relevant essential nutrients to 25% didn't significantly affect the values of the studied indicators, and the complete elimination of these substances resulted in massive death of animals. In the 2nd series a significant differences between the groups were observed from the range of increased mortality (groups with 2.15 and 4.62% content of essential nutrients) to the range of deviations from central tendency of some parameters (group with 21.37% content). The data allowed to trace the dependence of these differences on the levels of vitamins and minerals in the diet. The results were used to determine threshold values of vitamins and minerals that provided the necessary reduction of the adaptive potential level in male and female rats. Taking into account the risk of pathology development, three dosages of essential substances have been established - optimal, marginal and submarginal, which provide consistent decline of adaptive potential of laboratory animals: 75, 30 and 19% for males and 75, 28 and 18% for females, respectively. The modification of vitamin and mineral composition of the diet can be used as a model of adaptive potential reduce in toxicological research.
[Mh] Termos MeSH primário: Adaptação Psicológica/efeitos dos fármacos
Minerais/farmacologia
Complexo Vitamínico B/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Feminino
Masculino
Oxirredutases/sangue
Ratos
Ratos Wistar
Toxicologia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Minerals); 12001-76-2 (Vitamin B Complex); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE



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