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[PMID]:29431343
[Au] Autor:Ibraev SA; Pankin YN; Koygeldinova; Otarov EZ; Zharylkasyn Z; Izdenov AK; Alekseev AV; Zhumabekova GS; Tilemisov MK
[Ti] Título:[Longitudinal sstudy of differences between functional state of the body in workers at the chrysotile asbestos plant].
[So] Source:Gig Sanit;95(10):961-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There were performed biochemical and cytological studies of blood in healthy workers of chrysotile asbestos plant in order to determine the functional state of the body, depending on the length of service and working conditions. Mentioned differences between the functional state of the organism were determined in the longitudinal study, under construction on schedule time series with the test group at specified intervals (every year for 7 years surveyed, the same group of healthy workers). The differences between the indices allow one to discriminate different levels of the functional state of the organism for the workers employed at processing complex with experience of 4 and 5 years, and for the employees in the mining and transport workshop with the experience of 5 and 6 years. As a result the work experience of 5 years is considered to be an occupational hazard for workers at processing complex, and 6 years of experience - as an occupational hazard for workers of mining and transport workshop.
[Mh] Termos MeSH primário: Asbestos Serpentinas
Asbestos
Indústrias Extrativas e de Processamento/normas
Exposição Ocupacional
Medição de Risco/métodos
Local de Trabalho
[Mh] Termos MeSH secundário: Adulto
Feminino
Disparidades nos Níveis de Saúde
Seres Humanos
Cazaquistão/epidemiologia
Estudos Longitudinais
Masculino
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Fatores de Risco
Fatores de Tempo
Local de Trabalho/organização & administração
Local de Trabalho/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Serpentine); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29277245
[Au] Autor:Tranchant R; Montagne F; Jaurand MC; Jean D
[Ad] Endereço:Inserm, UMR-1162, génomique fonctionnelle des tumeurs solides, équipe 1 « Génomique des tumeurs hépatiques et mésothéliales ¼, 75010 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Labex Immuno-oncology, 12, rue de l'école de Médecine, 75006 Paris, France; Université Paris Diderot, S
[Ti] Título:[Molecular heterogeneity of malignant pleural mesotheliomas].
[Ti] Título:Hétérogénéité moléculaire des mésothéliomes pleuraux malins..
[So] Source:Bull Cancer;105(1):35-45, 2018 Jan.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Malignant pleural mesothelioma (MPM) is predominantly an occupational cancer, most often linked to asbestos exposure. Malignant pleural mesothelioma prognosis is poor with a short survival median, due to the aggressiveness of tumor cells and the weak efficiency of conventional anti-cancer therapies. Clinical, histological, and molecular data suggest tumor heterogeneity between patients as it was also shown for other cancer types. Consequently, there is an urgent need to develop new therapies that take into account this heterogeneity and the molecular characteristics of malignant pleural mesothelioma, in particular by identifying new anti-cancer drugs targeting the molecular specificities of each malignant pleural mesothelioma. Malignant pleural mesothelioma is characterized by numerous molecular alterations at the chromosomal, genetic and epigenetic levels. Molecular classification based on gene expression profile has firstly defined two tumor groups, C1 and C2, and more recently, four groups. By integrating genetic and transcriptomic analysis, a C2 tumor subgroup of the C2 group has been identified and characterized. In addition to tumor heterogeneity between patients, intra-tumor heterogeneity is supported by several evidences. Most therapeutic strategies that take into account the tumor molecular characteristics have focused on targeted therapies based on mutated genes. A more appropriate strategy would be to consider better-defined tumor groups on the basis of several molecular alterations types as it has been proposed for the C2 subgroup. A robust definition of homogeneous tumor groups sharing common molecular characteristics is necessary for the development of effective precision medicine for malignant pleural mesothelioma.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/genética
Mesotelioma/genética
Neoplasias Pleurais/genética
[Mh] Termos MeSH secundário: Asbestos/toxicidade
Carcinógenos/toxicidade
Aberrações Cromossômicas
Epigênese Genética
Seres Humanos
Neoplasias Pulmonares/classificação
Neoplasias Pulmonares/etiologia
Neoplasias Pulmonares/terapia
Mesotelioma/classificação
Mesotelioma/etiologia
Mesotelioma/terapia
Neoplasias Pleurais/classificação
Neoplasias Pleurais/etiologia
Neoplasias Pleurais/terapia
Prognóstico
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Carcinogens); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:29253374
[Au] Autor:Korda RJ; Clements MS; Armstrong BK; Law HD; Guiver T; Anderson PR; Trevenar SM; Kirk MD
[Ad] Endereço:National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Canberra, ACT, Australia. Electronic address: Rosemary.Korda@anu.edu.au.
[Ti] Título:Risk of cancer associated with residential exposure to asbestos insulation: a whole-population cohort study.
[So] Source:Lancet Public Health;2(11):e522-e528, 2017 Nov.
[Is] ISSN:2468-2667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The health risks associated with living in houses insulated with asbestos are unknown. Loose-fill asbestos was used to insulate some houses in the Australian Capital Territory (ACT). We compared the incidence of mesothelioma and other cancers in residents of the ACT who did and did not live in these houses. METHODS: Our cohort study included all ACT residents identified using Medicare enrolment data. These data were linked to addresses of affected residential properties in the ACT to ascertain exposure. We followed up residents by linking data to the Australian Cancer Database and National Death Index. Outcomes were diagnosis of mesothelioma and selected other cancers. Effects were estimated for males and females separately using standardised incidence ratios (SIRs), adjusting for age and calendar time of diagnosis. FINDINGS: Between Nov 1, 1983, and Dec 31, 2013, 1 035 578 ACT residents were identified from the Medicare database. Of these, 17 248 (2%) had lived in an affected property, including seven (2%) of 285 people diagnosed with mesothelioma. The adjusted incidence of mesothelioma in males who had lived at an affected property was 2·5 times that of unexposed males (SIR 2·54, 95% CI 1·02-5·24). No mesotheliomas were reported among females who had lived at an affected property. Among individuals who had lived at an affected property, there was an elevated incidence of colorectal cancer in women (SIR 1·73, 95% CI 1·29-2·26) and prostate cancer in men (1·29, 1·07-1·54); colorectal cancer was increased, although not significantly, in males (SIR 1·32, 95% CI 0·99-1·72), with no significant increase in the other cancers studied. INTERPRETATION: Residential asbestos insulation is likely to be unsafe. Our findings have important health, social, financial, and legal implications for governments and communities in which asbestos has been used to insulate houses. FUNDING: ACT Government.
[Mh] Termos MeSH primário: Asbestos/toxicidade
Exposição Ambiental/efeitos adversos
Habitação/estatística & dados numéricos
Neoplasias/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Austrália/epidemiologia
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias/epidemiologia
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1332-21-4 (Asbestos)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29182465
[Ti] Título:Author's response to: "Letter to the Editor" regarding content of "Mesothelioma from asbestos exposures: Epidemiologic patterns and impact in the United States" by R. A. Lemen, Journal of Toxicology and Environmental Health, Part B 2016; 19: 250-265.
[So] Source:J Toxicol Environ Health B Crit Rev;20(8):389, 2017.
[Is] ISSN:1521-6950
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Asbestos/análise
Mesotelioma
[Mh] Termos MeSH secundário: Saúde Ambiental
Neoplasias Pulmonares
Neoplasias Pleurais
Estados Unidos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
1332-21-4 (Asbestos)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1080/10937404.2017.1400769


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[PMID]:28740198
[Au] Autor:Granieri A
[Ad] Endereço:Department of Psychology, University of Turin, Via Po 14, 10123, Turin, Italy. antonella.granieri@unito.it.
[Ti] Título:The Drive For Self-Assertion And The Reality Principle In A Patient With Malignant Pleural Mesothelioma: The History of Giulia.
[So] Source:Am J Psychoanal;77(3):285-294, 2017 Sep.
[Is] ISSN:1573-6741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Life in a contaminated environment is often marked by a cumulative psychological trauma that exhibits a variety of social-environmental aspects. This is why I suggested a psychotherapeutic group intervention for the population of Casale Monferrato, a municipality in Northern Italy that is sadly renowned for asbestos-related events and the high mortality rate of its inhabitants. Groupality appears to show the point of contact between psyche and soma, while also promoting the birth of a more realistic approach to the various levels of suffering and their configuration. The multifamily approach seemed to be the most adequate to elaborate the feelings of rage and fear that are concurrent with the aerial contagion. In the "long wave" of group work we have learned to work with participants as well as with empty chairs, the ghosts of the dead: live traces in the mind. Whereas the mind recovers the possibility of entering into a dialogue with the feelings connected to the trauma, without bypassing them towards actions that are apparently more assertive of one's sense of Ego, the will of conciliation can reactivate a thought that is oriented towards the plane of reality.
[Mh] Termos MeSH primário: Asbestos/efeitos adversos
Família/psicologia
Mesotelioma/psicologia
Neoplasias Pleurais/psicologia
Apoio Social
Revelação da Verdade
[Mh] Termos MeSH secundário: Seres Humanos
Itália
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1332-21-4 (Asbestos)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1057/s11231-017-9099-0


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[PMID]:29197906
[Au] Autor:Glass WI; Clayson H
[Ad] Endereço:Centre for Public Health Research, Massey University, Wellington, Principle Advisor-Occupational Medicine, Technical Programmes and Support, WorkSafe, New Zealand Government, Wellington.
[Ti] Título:Asbestos-worker exposure, family disease.
[So] Source:N Z Med J;130(1466):90-91, 2017 Dec 01.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Family members, mostly female, can be at risk of asbestos-related disease as a result of the transfer of asbestos from the workplace to the home on the hair, boots and clothes of the worker. It is argued that in these cases the home should be recognised as an extension of the workplace and that the employer has a duty of care to contain and control the asbestos. Given these circumstances, the family member with the disease should be entitled to cover under the Accidence Compensation Legislation.
[Mh] Termos MeSH primário: Asbestos/toxicidade
Saúde da Família
Exposição por Inalação
Exposição Ocupacional
Indenização aos Trabalhadores
[Mh] Termos MeSH secundário: Saúde da Família/economia
Saúde da Família/legislação & jurisprudência
Seres Humanos
Neoplasias Pulmonares/induzido quimicamente
Neoplasias Pulmonares/economia
Mesotelioma/induzido quimicamente
Mesotelioma/economia
Indenização aos Trabalhadores/economia
Indenização aos Trabalhadores/legislação & jurisprudência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1332-21-4 (Asbestos)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE


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[PMID]:28468931
[Au] Autor:Araki T; Yanagawa M; Sun FJ; Dupuis J; Nishino M; Yamada Y; Washko GR; Christiani DC; Tomiyama N; O'Connor GT; Hunninghake GM; Hatabu H
[Ad] Endereço:Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:Pleural abnormalities in the Framingham Heart Study: prevalence and CT image features.
[So] Source:Occup Environ Med;74(10):756-761, 2017 Oct.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of pleural abnormalities in the general population is an epidemiologically important index of asbestos exposure, which has not been investigated since a radiography-based study in 1980. METHODS: We examined 2633 chest CT scans (mean 59.2 years, 50% female) from the Framingham Heart Study (FHS) for the presence and image characteristics of pleural plaques and diffuse pleural thickening. Demographics and pulmonary function were stratified by the presence of pleural abnormalities in association with interstitial lung abnormalities. RESULTS: Pleural abnormalities were present in 1.5% (95% CI 1.1% to 2.1%). Pleural lesions were most commonly bilateral (90.0%), multiple (77.5%), calcified (97.5%) and commonly involved posterior (lower: 92.5%, middle: 87.5%), anterior (upper: 77.5%, middle: 77.5%) and diaphragmatic areas (72.5%). Participants with pleural abnormalities were significantly older (75.7 years, p <0.0001), male (92.5%, p <0.0001), former or current smokers (80.0%, p <0.001) with higher pack-years (33.3, p <0.0001). No significant reduction was noted in pulmonary function measures (p=0.07-0.94) when adjusted for the associated covariates, likely due to small number of cases with pleural abnormalities. Information about prior history of asbestos exposure and occupation was not available. CONCLUSIONS: Pleural plaques and diffuse pleural thickening are present on CT in 1.5% of the FHS cohort. The current prevalence of the pleural abnormalities is smaller than that reported in the previous population-based study using chest radiography, likely representing lower asbestos exposure in recent decades. The posterior portion of the pleura is most frequently involved but the anterior portion is also commonly involved.
[Mh] Termos MeSH primário: Asbestos/efeitos adversos
Exposição Ambiental/efeitos adversos
Pleura/patologia
Doenças Pleurais/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Pulmão/efeitos dos fármacos
Pulmão/patologia
Masculino
Meia-Idade
Pleura/diagnóstico por imagem
Pleura/efeitos dos fármacos
Doenças Pleurais/diagnóstico por imagem
Doenças Pleurais/epidemiologia
Prevalência
Radiografia Torácica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1332-21-4 (Asbestos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-104178


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[PMID]:28935666
[Au] Autor:Marsh GM; Riordan AS; Keeton KA; Benson SM
[Ad] Endereço:Center for Occupational Biostatistics and Epidemiology and Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
[Ti] Título:Non-occupational exposure to asbestos and risk of pleural mesothelioma: review and meta-analysis.
[So] Source:Occup Environ Med;74(11):838-846, 2017 Nov.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To conduct an updated literature review and meta-analysis of studies of pleural malignant mesothelioma (PMM) risk among persons exposed to asbestos non-occupationally (household and neighbourhood). METHODS: We performed a literature search for articles available in the National Center for Biotechnology Information's PubMed database published between 1967 and 2016. Meta-analyses were conducted to calculate pooled PMM risk estimates, stratifying for household or neighbourhood exposure to asbestos and/or predominant asbestos fibre type (chrysotile, amphibole or mixed). RESULTS: Eighteen studies in 12 countries comprising 665 cases met the meta-analysis inclusion criteria. We identified 13 estimates of PMM risk from neighbourhood exposures, 10 from household and one from mixed exposure, and combined the estimates using random-effects models. The overall meta-relative risk (meta-RR) was 5.9 (95% CI 4.4 to 8.7). The meta-RRs for household and neighbourhood exposures were 5.4 (95% CI 2.6 to 11.2) and 6.9 (95% CI 4.2 to 11.4), respectively. We observed trends in risk in relation to fibre type for both household and neighbourhood studies. For chrysotile, mixed and amphibole fibres, respectively, meta-RRs for neighbourhood studies were 3.8 (95% CI 0.4 to 38.4), 8.4 (95% CI 4.7 to 14.9) and 21.1 (95% CI 5.3 to 84.5) and meta-RRs for household studies were 4.0 (95% CI 0.8 to 18.8), 5.3 (95% CI 1.9 to 15.0) and 21.1 (95% CI 2.8 to 156.0). CONCLUSIONS: PMM risks from non-occupational asbestos exposure are consistent with the fibre-type potency response observed in occupational settings. By relating our findings to knowledge of exposure-response relationships in occupational settings, we can better evaluate PMM risks in communities with ambient asbestos exposures from industrial or other sources.
[Mh] Termos MeSH primário: Asbestos/efeitos adversos
Exposição Ambiental/efeitos adversos
Habitação
Neoplasias Pulmonares/induzido quimicamente
Mesotelioma/induzido quimicamente
Neoplasias Pleurais/induzido quimicamente
Distribuição Espacial da População
[Mh] Termos MeSH secundário: Asbestos Serpentinas/efeitos adversos
Exposição Ambiental/análise
Feminino
Seres Humanos
Masculino
Exposição Ocupacional
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Asbestos, Serpentine); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2017-104383


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[PMID]:28811147
[Au] Autor:Witek J; Kusiorowski R
[Ad] Endereço:Institute of Ceramics and Building Materials, Refractory Materials Division in Gliwice, ul. Toszecka 99, 44-100 Gliwice, Poland.
[Ti] Título:Neutralization of cement-asbestos waste by melting in an arc-resistance furnace.
[So] Source:Waste Manag;69:336-345, 2017 Nov.
[Is] ISSN:1879-2456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The paper presents the results of research on asbestos waste disposal by the melting process. The tests were carried out in a laboratory arc-resistance electric furnace. The obtained results showed that the fibrous structure of asbestos contained in cement-asbestos waste was completely destroyed. This led to the formation of new mineral phases without dangerous properties. The melting test was conducted on raw cement-asbestos samples without any additives and with a content of mineral compounds, the aim of which was to support the melting process. The additives were selected among others on the basis of the computer simulation results carried out using FactSage database computing system. The research results indicate that the melting process of asbestos wastes is a potential and interesting method of neutralizing hazardous asbestos waste, which allows for further treatment and material recycling.
[Mh] Termos MeSH primário: Asbestos/química
Materiais de Construção
Resíduos Industriais/análise
Eliminação de Resíduos/métodos
[Mh] Termos MeSH secundário: Simulação por Computador
Resíduos Perigosos
Reciclagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Waste); 0 (Industrial Waste); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


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[PMID]:28759607
[Au] Autor:Wroble J; Frederick T; Frame A; Vallero D
[Ad] Endereço:Office of Environmental Review and Assessment (OERA), United States Environmental Protection Agency Region 10, Seattle, Washington, United States of America.
[Ti] Título:Comparison of soil sampling and analytical methods for asbestos at the Sumas Mountain Asbestos Site-Working towards a toolbox for better assessment.
[So] Source:PLoS One;12(7):e0180210, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Established soil sampling methods for asbestos are inadequate to support risk assessment and risk-based decision making at Superfund sites due to difficulties in detecting asbestos at low concentrations and difficulty in extrapolating soil concentrations to air concentrations. Environmental Protection Agency (EPA)'s Office of Land and Emergency Management (OLEM) currently recommends the rigorous process of Activity Based Sampling (ABS) to characterize site exposures. The purpose of this study was to compare three soil analytical methods and two soil sampling methods to determine whether one method, or combination of methods, would yield more reliable soil asbestos data than other methods. Samples were collected using both traditional discrete ("grab") samples and incremental sampling methodology (ISM). Analyses were conducted using polarized light microscopy (PLM), transmission electron microscopy (TEM) methods or a combination of these two methods. Data show that the fluidized bed asbestos segregator (FBAS) followed by TEM analysis could detect asbestos at locations that were not detected using other analytical methods; however, this method exhibited high relative standard deviations, indicating the results may be more variable than other soil asbestos methods. The comparison of samples collected using ISM versus discrete techniques for asbestos resulted in no clear conclusions regarding preferred sampling method. However, analytical results for metals clearly showed that measured concentrations in ISM samples were less variable than discrete samples.
[Mh] Termos MeSH primário: Asbestos/análise
Monitoramento Ambiental/métodos
Exposição por Inalação/análise
Exposição Ocupacional/análise
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Microscopia Eletrônica de Transmissão
Medição de Risco
Solo
Estados Unidos
United States Environmental Protection Agency
Washington
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180210



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