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[PMID]:28870655
[Au] Autor:Pfau JC; Buck B; Metcalf RV; Kaupish Z; Stair C; Rodriguez M; Keil DE
[Ad] Endereço:Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: jean.pfau@montana.edu.
[Ti] Título:Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona.
[So] Source:Toxicol Appl Pharmacol;334:24-34, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards. The objective was to compare the health outcomes in mice exposed to either LAA or the fibrous amphiboles collected in Arizona at the Lake Mead National Recreational Area at very low doses to represent environmental exposures. In this study, the fibrous amphibole asbestos sample from Arizona (AzA) is composed of winchite (69%), actinolite (22%), and non-amphibole minerals (9%) and has a mean aspect ratio of 16.7±0.9. Fibrous amphibole asbestos from Libby (LAA) is composed of winchite (70%), richterite (9%), tremolite (5%), and non-amphibole minerals (16%) with a mean aspect ratio of 8.4±0.7. C57BL/6 mice were exposed by oropharyngeal aspiration to fiber suspensions at a very low dose of 3µg/mouse. After seven months, both LAA- and AzA-exposed mice had indices of chronic immune dysfunction related to a T 17 cytokine profile, with B cell activation, autoantibody production and proteinuria, suggesting kidney involvement. In addition, both exposures led to significant lung and pleural fibrosis. These data suggest that there is risk of pulmonary disease and autoimmune outcomes with environmental exposure to amphibole asbestos, and that this is not limited to Libby, Montana.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/toxicidade
Peso Corporal/efeitos dos fármacos
Baço/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração por Inalação
Albuminúria
Animais
Anticorpos Antinucleares
Arizona
Amiantos Anfibólicos/administração & dosagem
Autoanticorpos
Citocinas/genética
Citocinas/metabolismo
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Subpopulações de Linfócitos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Nevada
Tamanho do Órgão
Proteinúria
Baço/citologia
Baço/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Asbestos, Amphibole); 0 (Autoantibodies); 0 (Cytokines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


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[PMID]:28697481
[Au] Autor:Ryan PH; Rice CH; Lockey JE; Black B; Burkle J; Hilbert TJ; Levin L; Brokamp C; McKay R; Wolfe C; LeMasters GK
[Ad] Endereço:Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA. Electronic address: patrick.ryan@cchmc.org.
[Ti] Título:Childhood exposure to Libby amphibole asbestos and respiratory health in young adults.
[So] Source:Environ Res;158:470-479, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Vermiculite ore containing Libby amphibole asbestos (LAA) was mined in Libby, MT, from the 1920s-1990. Recreational and residential areas in Libby were contaminated with LAA. This objective of this study was to characterize childhood exposure to LAA and investigate its association with respiratory health during young adulthood. METHODS: Young adults who resided in Libby prior to age 18 completed a health and activity questionnaire, pulmonary function testing, chest x-ray and HRCT scan. LAA exposure was estimated based on participant report of engaging in activities with potential LAA exposure. Quantitative LAA estimates for activities were derived from sampling data and literature reports. RESULTS: A total of 312 participants (mean age 25.1 years) were enrolled and reported respiratory symptoms in the past 12 months including pleuritic chest pain (23%), regular cough (17%), shortness of breath (18%), and wheezing or whistling in the chest (18%). Cumulative LAA exposure was significantly associated with shortness of breath (aOR = 1.12, 95% CI 1.01-1.25 per doubling of exposure). Engaging in recreational activities near Rainy Creek Road (near the former mine site) and the number of instances heating vermiculite ore to make it expand or pop were also significantly associated with respiratory symptoms. LAA exposure was not associated with pulmonary function or pleural or interstitial changes on either chest x-ray or HRCT. CONCLUSIONS: Pleural or interstitial changes on x-ray or HRCT were not observed among this cohort of young adults. However, childhood exposure to LAA was significantly associated with respiratory symptoms during young adulthood. Pleuritic chest pain, in particular, has been identified as an early symptom associated with LAA exposure and therefore warrants continued follow-up given findings of progressive disease in other LAA exposed populations.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/toxicidade
Exposição Ambiental
Pulmão/fisiopatologia
Doenças Respiratórias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Seres Humanos
Lactente
Pulmão/patologia
Masculino
Mineração
Montana/epidemiologia
Testes de Função Respiratória
Doenças Respiratórias/induzido quimicamente
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Asbestos, Amphibole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE


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[PMID]:28641716
[Au] Autor:Clark KA; Flynn JJ; Karmaus WJJ; Mohr LC
[Ad] Endereço:Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. Electronic address: clarkka2@mailbox.sc.edu.
[Ti] Título:The Effects of Pleural Plaques on Longitudinal Lung Function in Vermiculite Miners of Libby, Montana.
[So] Source:Am J Med Sci;353(6):533-542, 2017 Jun.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor >1cm in diameter. Random intercept and slope linear mixed-effect regression models identified differences in lung function decline between miners with asbestos-associated outcomes and those with normal HRCT. Models were adjusted for follow-up time, body mass index, smoking status, latent exposure period and employment years. Interactions for smoking status with age and smoking status with pleural plaque severity were examined. RESULTS: Miners with PP only did not have an accelerated decline in lung function between 40 and 80 years. Miners with PP and additional HRCT abnormalities displayed significantly accelerated declines in forced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide (P = 0.05 and P < 0.01, respectively). Plaque severity did not affect lung function decline. However, smokers with extensive plaques displayed accelerated loss in diffusing capacity of the lungs for carbon monoxide and forced expiratory volume in 1 second when compared to nonsmoking miners with mild plaque formation. CONCLUSIONS: PP alone did not significantly affect lung function decline in vermiculite miners of Libby, Montana.
[Mh] Termos MeSH primário: Amiantos Anfibólicos
Pulmão/fisiopatologia
Mineradores
Exposição Ocupacional
Doenças Pleurais/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Silicatos de Alumínio
Amiantos Anfibólicos/toxicidade
Seres Humanos
Estudos Longitudinais
Pulmão/efeitos dos fármacos
Masculino
Meia-Idade
Montana
Doenças Pleurais/induzido quimicamente
Testes de Função Respiratória
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Asbestos, Amphibole); 1318-00-9 (vermiculite)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE


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[PMID]:28395242
[Au] Autor:Rapisarda V; Caltabiano R; Musumeci G; Castrogiovanni P; Ferrante M; Ledda C; Lombardo C; Graziano ACE; Cardile V; Loreto C
[Ad] Endereço:Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Italy.
[Ti] Título:Analysis of fibulin-3 after exposure to asbestos-like fibers.
[So] Source:Environ Res;156:381-387, 2017 07.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A significantly increased incidence of malignant mesothelioma in Biancavilla (Sicily, Italy) has been ascribed to exposure to fluoro-edenite, a fibrous amphibole extracted from a local stone quarry. Fibulin-3 is a highly conserved glycoprotein proposed as a biomarker for malignant mesothelioma that belongs to the family of extracellular matrix proteins. Previous studies demonstrated high Fibulin-3 plasma levels in workers with pleural plaques exposed to fluoro-edenite. Therefore, in order to gain insight into the biomolecular mechanisms of fluoro-edenite toxicity, we performed the analysis of Fibulin-3 expression by immunohistochemistry in the lung samples derived from sheep belonging to the area of Biancavilla. Furthermore, an in vitro model of exposed fluoro-edenite fibroblasts was used to perform functional experiments to better understand the modulation of Fibulin-3 expression. The percentage of immunostained area by Fibulin-3 was very much higher in exposed lungs compared with non-exposed ones. The Fibulin-3 protein level was significantly expressed in primary human lung fibroblasts exposed to 50 and 100µg/ml of fluoro-edenite fibers for 72h, compared to the unexposed controls. The results from the present study further demonstrate the implication of Fibulin-3 during fluoro-edenite exposure. This would endorse our previous results regarding the use of Fibulin-3 as a possible screening biomarker for fluoro-edenite exposed individuals, thereby contributing to the monitoring of the population at risk. The present study also suggested that the Fibulin-3 overexpression may reflect a defensive response of the tissues after exogenous stimuli and may be implicated in cancer development, especially in the context of fluoro-edenite contamination. However, further studies are necessary in order to make Fibulin-3 a customized screening tool.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/toxicidade
Biomarcadores/sangue
Proteínas de Ligação ao Cálcio/genética
Fibroblastos/efeitos dos fármacos
Expressão Gênica/efeitos dos fármacos
Pulmão/efeitos dos fármacos
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/toxicidade
Animais
Proteínas de Ligação ao Cálcio/metabolismo
Modelos Animais de Doenças
Feminino
Seres Humanos
Imuno-Histoquímica
Itália
Masculino
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Asbestos, Amphibole); 0 (Biomarkers); 0 (Calcium-Binding Proteins); 0 (fibulin); 0 (fluor-edenite)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:27680005
[Au] Autor:Godoi RHM; Gonçalves SJ; Sayama C; Polezer G; Reis Neto JM; Alföldy B; Van Grieken R; Riedi CA; Yamamoto CI; Godoi AFL; Bencs L
[Ad] Endereço:Department of Environmental Engineering, Federal University of Paraná/UFPR, Curitiba, Paraná, Brazil.
[Ti] Título:Health implications of atmospheric aerosols from asbestos-bearing road pavements traditionally used in Southern Brazil.
[So] Source:Environ Sci Pollut Res Int;23(24):25180-25190, 2016 Dec.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Serpentine and amphibole asbestos occur naturally in certain geologic settings worldwide, most commonly in association with ultramafic rocks, along associated faults. Ultramafic rocks have been used in Piên County, Southern Brazil for decades for the purpose of road paving in rural and urban areas, but without the awareness of their adverse environmental and health impact. The aim of this study was the chemical characterization of aerosols re-suspended in two rural roads of Piên, paved with ultramafic rocks and to estimate the pulmonary deposition of asbestos aerosols. Bulk aerosol samples were analyzed by means of X-ray fluorescence spectrometry and X-ray diffraction analysis, in order to characterize elemental composition and crystallinity. Single-particle compositions of aerosols were analyzed by computer-controlled electron-probe microanalysis, indicating the presence of a few percentages of serpentine and amphibole. Given the chemical composition and size distribution of aerosol particles, the deposition efficiency of chrysotile, a sub-group of serpentine, in two principal segments of the human respiratory system was estimated using a lung deposition model. As an important finding, almost half of the inhaled particles were calculated to be deposited in the respiratory system. Asbestos depositions were significant (∼25 %) in the lower airways, even though the selected breathing conditions (rest situation, nose breathing) implied the lowest rate of respiratory deposition. Considering the fraction of inhalable suspended chrysotile near local roads, and the long-term exposure of humans to these aerosols, chrysotile may represent a hazard, regarding more frequent development of lung cancer in the population of the exposed region.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/análise
Asbestos Serpentinas/análise
[Mh] Termos MeSH secundário: Aerossóis
Amiantos Anfibólicos/farmacocinética
Amiantos Anfibólicos/toxicidade
Asbestos Serpentinas/farmacocinética
Asbestos Serpentinas/toxicidade
Brasil
Seres Humanos
Exposição por Inalação
Neoplasias Pulmonares
Modelos Biológicos
Sistema Respiratório/metabolismo
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Asbestos, Amphibole); 0 (Asbestos, Serpentine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7586-0


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[PMID]:27669761
[Au] Autor:Ledda C; Loreto C; Matera S; Massimino N; Cannizzaro E; Musumeci A; Migliore M; Fenga C; Pomara C; Rapisarda V
[Ad] Endereço:Department of Clinical & Experimental Medicine, Occupational Medicine, University of Catania, Catania, Italy.
[Ti] Título:Early effects of fluoro-edenite: correlation between IL-18 serum levels and pleural and parenchymal abnormalities.
[So] Source:Future Oncol;12(23s):59-62, 2016 Dec.
[Is] ISSN:1744-8301
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fluoro-edenite (FE) is a natural mineral asbestos-like fibrous species first isolated in Biancavilla, Sicily. In order to clarify potential involvement of IL-18 in the pathogenesis of FE-induced chest abnormalities, we analyzed IL-18 serum levels in FE-exposed workers (FEEW) and correlated them with pleural and parenchymal abnormalities. A total of 21 FEEWs, residing in Biancavilla for >30 years, with a working seniority of 17 ± 6.1 years were examined. High-resolution computed tomography scans revealed low grade of fibrosis in 8 (38%) FEEWs, and pleural plaques (PPs) in 13 (62%) FEEWs. The mean IL-18 level was 203.13 ± 90.43 pg/ml. Pearson correlation showed a significant association (p < 0.0001) between IL-18 and PPs and parenchymal abnormality scores. Data suggest a potential role of IL-18 in the pathogenesis of these diseases.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/efeitos adversos
Interleucina-18/sangue
Doenças Pulmonares Intersticiais/sangue
Doenças Pulmonares Intersticiais/etiologia
Exposição Ocupacional/efeitos adversos
Doenças Pleurais/sangue
Doenças Pleurais/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Doenças Pulmonares Intersticiais/diagnóstico
Doenças Pulmonares Intersticiais/epidemiologia
Masculino
Meia-Idade
Doenças Pleurais/diagnóstico
Doenças Pleurais/epidemiologia
Testes de Função Respiratória
Fatores de Risco
Tomografia Computadorizada Espiral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Amphibole); 0 (Interleukin-18); 0 (fluor-edenite)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE


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[PMID]:27624550
[Au] Autor:Ledda C; Loreto C; Bracci M; Mangano D; Migliore M; Ricceri V; Musumeci A; Costa C; Pomara C; Rapisarda V
[Ad] Endereço:Occupational Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
[Ti] Título:High risk of pleural plaques and parenchymal abnormalities in women living in Biancavilla (Italy).
[So] Source:Future Oncol;12(23s):63-65, 2016 Dec.
[Is] ISSN:1744-8301
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fluoro-edenite is a natural mineral species first isolated in Biancavilla, Sicily, used for construction of houses and roads, with health effects allegedly the same as those of asbestos. The aim of the current study was to evaluate the risks of pleural plaques and parenchymal abnormalities in women living in Biancavilla through a retrospective cross-sectional study. The evaluation pointed out a relative risk of pleural plaques of 39.67 (95% CI: 11.33-138.82) and 27.67 (95% CI: 5.43-141.00) for parenchymal abnormalities as well. These findings have prompted urge to extend the screening on the possible abnormalities of the respiratory tract to all Biancavilla's population, particularly in those aged more than 30 years.
[Mh] Termos MeSH primário: Doenças Pulmonares Intersticiais/epidemiologia
Doenças Pulmonares Intersticiais/etiologia
Doenças Pleurais/epidemiologia
Doenças Pleurais/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Amiantos Anfibólicos/efeitos adversos
Estudos Transversais
Feminino
Seres Humanos
Doenças Pulmonares Intersticiais/diagnóstico
Meia-Idade
Exposição Ocupacional/efeitos adversos
Doenças Pleurais/diagnóstico
Vigilância da População
Estudos Retrospectivos
Risco
Sicília/epidemiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Amphibole); 0 (fluor-edenite)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE


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[PMID]:27524060
[Au] Autor:Eilbagi M; Emadi R; Raeissi K; Kharaziha M; Valiani A
[Ad] Endereço:Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
[Ti] Título:Mechanical and cytotoxicity evaluation of nanostructured hydroxyapatite-bredigite scaffolds for bone regeneration.
[So] Source:Mater Sci Eng C Mater Biol Appl;68:603-12, 2016 Nov 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Despite the attractive characteristics of three-dimensional pure hydroxyapatite (HA) scaffolds, due to their weak mechanical properties, researches have focused on the development of composite scaffolds via introducing suitable secondary components. The aim of this study was to develop, for the first time, three-dimensional HA-bredigite (Ca7MgSi4O16) scaffolds containing various amounts of bredigite nanopowder (0, 5, 10 and 15wt.%) using space holder technique. Transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and X-ray diffraction spectroscopy were applied in order to study the morphology, fracture surface and phase compositions of nanopowders and scaffolds. Furthermore, the effects of scaffold composition on the mechanical properties, bioactivity, biodegradability, and cytotoxicity were also evaluated. Results showed that the composite scaffolds with average pore size in the range of 220-310µm, appearance porosity of 63.1-75.9% and appearance density of 1.1±0.04g/cm(3) were successfully developed, depending on bredigite content. Indeed, the micropore size of the scaffolds reduced with increasing bredigite content confirming that the sinterability of the scaffolds was improved. Furthermore, the compression strength and modulus of the scaffolds significantly enhanced via incorporation of bredigite content from 0 to 15wt.%. The composite scaffolds revealed superior bioactivity and biodegradability with increasing bredigite content. Moreover, MTT assay confirmed that HA-15wt.% bredigite scaffold significantly promoted cell proliferation compared to tissue culture plate (control) and HA scaffold. Based on these results, three-dimensional HA-bredigite scaffolds could be promising replacements for HA scaffolds in bone regeneration.
[Mh] Termos MeSH primário: Amiantos Anfibólicos
Regeneração Óssea/efeitos dos fármacos
Substitutos Ósseos
Durapatita
Nanoestruturas/química
Tecidos Suporte/química
[Mh] Termos MeSH secundário: Amiantos Anfibólicos/química
Amiantos Anfibólicos/farmacocinética
Amiantos Anfibólicos/farmacologia
Substitutos Ósseos/química
Substitutos Ósseos/farmacocinética
Substitutos Ósseos/farmacologia
Linhagem Celular Tumoral
Avaliação Pré-Clínica de Medicamentos
Durapatita/química
Durapatita/farmacocinética
Durapatita/farmacologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Amphibole); 0 (Bone Substitutes); 14567-73-8 (tremolite); 91D9GV0Z28 (Durapatite)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE


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[PMID]:27519611
[Au] Autor:Hanson R; Evilia C; Gilmer J; Woods L; Black B; Flores R; Pfau JC
[Ad] Endereço:Department of Biological Sciences, Idaho State University, Pocatello, Idaho.
[Ti] Título:Libby amphibole-induced mesothelial cell autoantibodies bind to surface plasminogen and alter collagen matrix remodeling.
[So] Source:Physiol Rep;4(15), 2016 08.
[Is] ISSN:2051-817X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lamellar pleural thickening (LPT) is a fibrotic disease induced by exposure to Libby amphibole (LA) asbestos that causes widespread scarring around the lung, resulting in deterioration of pulmonary function. Investigating the effects of autoantibodies to mesothelial cells (MCAA) present in the study populations has been a major part of the effort to understand the mechanism of pathogenesis. It has been shown in vitro that human mesothelial cells (Met5a) exposed to MCAA increase collagen deposition into the extracellular matrix (ECM). In this study, we sought to further elucidate how MCAA drive increased collagen deposition by identifying the protein targets bound by MCAA on the cellular surface using biotinylation to label and isolate surface proteins. Isolated surface protein fractions were identified as containing MCAA targets using ELISA The fractions that demonstrated binding by MCAA were then analyzed by tandem mass spectrometry (MS/MS) and MASCOT analysis. The most promising result from the MASCOT analysis, plasminogen (PLG), was tested for MCAA binding using purified human PLG in an ELISA We report that serum containing MCAA bound at an optical density (OD) 3 times greater than that of controls, and LA-exposed subjects had a high frequency of positive tests for anti-PLG autoantibodies. This work implicates the involvement of the plasminogen/plasmin system in the mechanism of excess collagen deposition in Met5a cells exposed to MCAA Elucidating this mechanism could contribute to the understanding of LPT.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/metabolismo
Autoanticorpos/metabolismo
Colágeno/imunologia
Epitélio/imunologia
Plasminogênio/imunologia
[Mh] Termos MeSH secundário: Idoso
Amiantos Anfibólicos/efeitos adversos
Células Cultivadas
Colágeno/metabolismo
Epitélio/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Plasminogênio/metabolismo
Mapas de Interação de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Asbestos, Amphibole); 0 (Autoantibodies); 9001-91-6 (Plasminogen); 9007-34-5 (Collagen)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160814
[St] Status:MEDLINE


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[PMID]:27349291
[Au] Autor:Musumeci G; Loreto C; Giunta S; Rapisarda V; Szychlinska MA; Imbesi R; Castorina A; Annese T; Castorina S; Castrogiovanni P; Ribatti D
[Ad] Endereço:Department of Biomedical Sciences and Biotechnologies, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy.
[Ti] Título:Angiogenesis correlates with macrophage and mast cell infiltration in lung tissue of animals exposed to fluoro-edenite fibers.
[So] Source:Exp Cell Res;346(1):91-8, 2016 Aug 01.
[Is] ISSN:1090-2422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Angiogenesis plays a crucial role in progression of pleural malignant mesothelioma. A significantly increased incidence of pleural mesothelioma has been attributed to exposure to fluoro-edenite, a fibrous amphibole extracted from a local stone quarry. In this study, we have investigated the expression of CD68-positive macrophages, tryptase-positive mast cells and CD31 positive areas, as expression of microvascular density, in lung tissue of sheeps exposed to fluoro-edenite fibers vs controls, by immunohistochemical, morphometric and Western blot analysis. The result have evidenced a significant increase in the expression of CD68-positive macrophages, tryptase-positive mast cells as well as a significant increase in microvascular density evaluated as CD31 positive areas in lung tissue of of sheeps exposed to fluoro-edenite fibers vs controls. These data confirmed the important role played by tumor microenvironment components, including macrophages and mast cells, in favour of angiogenesis in pleural mesothelioma induced by fluoro-edenite exposure.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/toxicidade
Pulmão/patologia
Macrófagos/metabolismo
Mastócitos/metabolismo
Neovascularização Fisiológica
[Mh] Termos MeSH secundário: Animais
Antígenos CD/metabolismo
Western Blotting
Densitometria
Feminino
Imuno-Histoquímica
Pulmão/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Masculino
Mastócitos/efeitos dos fármacos
Mastócitos/enzimologia
Neovascularização Fisiológica/efeitos dos fármacos
Ovinos
Coloração e Rotulagem
Triptases/metabolismo
Tubulina (Proteína)/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Asbestos, Amphibole); 0 (Tubulin); 0 (fluor-edenite); EC 3.4.21.59 (Tryptases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE



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