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[PMID]:29193587
[Au] Autor:Ohara Y; Chew SH; Shibata T; Okazaki Y; Yamashita K; Toyokuni S
[Ad] Endereço:Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan.
[Ti] Título:Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats.
[So] Source:Cancer Sci;109(2):330-339, 2018 Feb.
[Is] ISSN:1349-7006
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. Malignant mesothelioma is difficult to diagnose at an early stage, yet there are no particularly effective treatments available at the advanced stage, thus necessitating efficient strategies to prevent MM in individuals already exposed to asbestos. We previously showed that persistent oxidative damage caused by foreign body reaction and affinity of asbestos both to hemoglobin and histones is one of the major pathogeneses. Accordingly, as an effective strategy to prevent asbestos-induced MM, we undertook the use of an iron chelator, deferasirox, which decreased the epithelial-mesenchymal transition in a crocidolite-induced rat MM model. However, this agent may show adverse effects. Here, we studied the effects of iron removal by phlebotomy as a realistic measure on the same rat model. We injected a total of 5 mg crocidolite i.p. to F1 hybrid rats between the Fischer-344 and Brown-Norway strains at the age of 6 weeks. We repeated weekly or biweekly phlebotomy of 6-8 mL/kg/time from 10 to 60 weeks of age. The animals were observed until 120 weeks. In male rats, phlebotomy significantly decreased the weight and nuclear grade of MM, and modestly reduced the associated ascites and the fraction of more malignant sarcomatoid subtype. Weekly phlebotomy prolonged long-term survival. Our results indicate that appropriate phlebotomy may be a practical preventive measure to attenuate the initiation and promotion capacity of asbestos towards MM by reducing iron in individuals exposed to asbestos.
[Mh] Termos MeSH primário: Asbesto Crocidolita/toxicidade
Neoplasias Pulmonares/induzido quimicamente
Neoplasias Pulmonares/prevenção & controle
Mesotelioma/induzido quimicamente
Mesotelioma/prevenção & controle
Flebotomia/métodos
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Ferro/sangue
Neoplasias Pulmonares/sangue
Neoplasias Pulmonares/patologia
Masculino
Mesotelioma/sangue
Mesotelioma/patologia
Ratos
Análise de Sobrevida
Resultado do Tratamento
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12001-28-4 (Asbestos, Crocidolite); E1UOL152H7 (Iron)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/cas.13460


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[PMID]:27619065
[Au] Autor:Pollastri S; Gualtieri AF; Vigliaturo R; Ignatyev K; Strafella E; Pugnaloni A; Croce A
[Ad] Endereço:Department of Chemical and Geological Sciences, The University of Modena and Reggio Emilia, Via Campi 103, I-41125, Modena, Italy. Electronic address: simone.pollastri@unimore.it.
[Ti] Título:Stability of mineral fibres in contact with human cell cultures. An in situ µXANES, µXRD and XRF iron mapping study.
[So] Source:Chemosphere;164:547-557, 2016 Dec.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Relevant mineral fibres of social and economic importance (chrysotile UICC, crocidolite UICC and a fibrous erionite from Jersey, Nevada, USA) were put in contact with cultured diploid human non-tumorigenic bronchial epithelial (Beas2B) and pleural transformed mesothelial (MeT5A) cells to test their cytotoxicity. Slides of each sample at different contact times up to 96 h were studied in situ using synchrotron XRF, µ-XRD and µ-XAS (I18 beamline, Diamond Light Source, UK) and TEM investigations. XRF maps of samples treated for 96 h evidenced that iron is still present within the chrysotile and crocidolite fibres and retained at the surface of the erionite fibres, indicating its null to minor mobilization in contact with cell media; this picture was confirmed by the results of XANES pre-edge analyses. µ-XRD and TEM data indicate greater morphological and crystallinity modifications occurring in chrysotile, whereas crocidolite and erionite show to be resistant in the biological environment. The contact of chrysotile with the cell cultures seems to lead to earlier amorphization, interpreted as the first dissolution step of these fibres. The formation of such silica-rich fibre skeleton may prompt the production of HO in synergy with surface iron species and could indicate that chrysotile may be much more reactive and cytotoxic in vitro in the (very) short term whereas the activity of crocidolite and erionite would be much more sluggish but persistent in the long term.
[Mh] Termos MeSH primário: Asbesto Crocidolita/química
Asbestos Serpentinas/química
Ferro/análise
Fibras Minerais/análise
Zeolitas/química
[Mh] Termos MeSH secundário: Animais
Asbesto Crocidolita/toxicidade
Asbestos Serpentinas/toxicidade
Brônquios/efeitos dos fármacos
Carcinogênese/induzido quimicamente
Linhagem Celular
Seres Humanos
Ferro/toxicidade
Fibras Minerais/toxicidade
Mucosa Respiratória/efeitos dos fármacos
Zeolitas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Serpentine); 0 (Mineral Fibers); 12001-28-4 (Asbestos, Crocidolite); 12510-42-8 (erionite); 1318-02-1 (Zeolites); E1UOL152H7 (Iron)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


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[PMID]:27542398
[Au] Autor:Franklin P; Alfonso H; Reid A; Olsen N; Shilkin KB; Brims F; de Klerk N; Musk AW
[Ad] Endereço:School of Population Health, University of Western Australia, Nedlands, Western Australia, Australia.
[Ti] Título:Asbestos exposure and histological subtype of malignant mesothelioma.
[So] Source:Occup Environ Med;73(11):749-752, 2016 Nov.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Malignant mesothelioma (MM) has distinct histological subtypes (epithelioid, sarcomatoid and biphasic) with variable behaviour and prognoses. It is well recognised that survival time varies with the histological subtype of MM. It is not known, however, if asbestos exposure characteristics (type of asbestos, degree of exposure) are associated with different histological subtypes. AIM: To determine if the pathological MM subtype is associated with the type of asbestos or the attributes of asbestos exposure. METHODS: Cases of MM for the period 1962 until 2012, their main histological subtype and their most significant source of asbestos exposure were collected from the Western Australian Mesothelioma Registry. Exposure characteristics included, degree of asbestos exposure (including total days exposed, years since first exposure and, for crocidolite only, calculated cumulative exposure), source of exposure (occupational or environmental), form of asbestos handled (raw or processed) and type of asbestos (crocidolite only or mixed fibres). RESULTS: Patients with the biphasic subtype were more likely to have occupational exposure (OR 1.83, 1.12 to 2.85) and exposure to raw fibres (OR 1.58, 1.19 to 2.10). However, differences between subtypes in the proportions with these different exposure characteristics were small and unlikely to be biologically relevant. Other indicators of asbestos exposure were not associated with the histological subtype of mesothelioma. CONCLUSIONS: There was no strong evidence of a consistent role of asbestos exposure indicators in determining the histological subtype of MM.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/induzido quimicamente
Neoplasias Pulmonares/patologia
Mesotelioma/induzido quimicamente
Mesotelioma/patologia
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Asbestos
Asbesto Crocidolita/efeitos adversos
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Mineração
Doenças Profissionais/induzido quimicamente
Doenças Profissionais/patologia
Prognóstico
Sistema de Registros
Inquéritos e Questionários
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12001-28-4 (Asbestos, Crocidolite); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160821
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103721


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[PMID]:27372959
[Au] Autor:Franklin P; Reid A; Olsen N; Peters S; de Klerk N; Brims F; Threlfall T; Murray R; Musk AB
[Ad] Endereço:School of Population Health, The University of Western Australia.
[Ti] Título:Incidence of malignant mesothelioma in Aboriginal people in Western Australia.
[So] Source:Aust N Z J Public Health;40(4):383-7, 2016 Aug.
[Is] ISSN:1753-6405
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To describe the incidence of malignant mesothelioma (MM) in Aboriginal people in Western Australia (WA) and determine the main routes of exposure to asbestos in this population. METHODS: All MM cases in Western Australia, as well as the primary source of asbestos exposure, are recorded in the WA Mesothelioma Register. Aboriginal cases up to the end of 2013 were extracted from the register and compared with non-Aboriginal cases with respect to the primary means/source of exposure. Age-standardised incidence rates for each decade from 1980 were calculated for both Aboriginals and non-Aboriginals. Age-standardised mortality rates were calculated for the period 1994-2008 and compared with international rates. RESULTS: There were 39 cases (77% male) of MM among WA Aboriginal people. Twenty-six (67%) were a direct result of the mining of crocidolite at Wittenoom and the subsequent contamination of the surrounding lands. Of the non-Aboriginal MM cases (n = 2070, 86.3% male), fewer than 25% can be attributed to Wittenoom. Aboriginals had consistently higher 10-year incidence rates than non-Aboriginals and, when compared to world populations, the highest mortality rate internationally. CONCLUSION: When incidence rates in Aboriginal people are compared with non-Aboriginal people, the Wittenoom mining operation has had a disproportionate effect on MM incidence in the local Aboriginal population.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/epidemiologia
Mesotelioma/epidemiologia
Exposição Ocupacional/estatística & dados numéricos
Grupo com Ancestrais Oceânicos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Asbestos
Asbesto Crocidolita
Causalidade
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Mineração/estatística & dados numéricos
Sistema de Registros/estatística & dados numéricos
Austrália Ocidental/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12001-28-4 (Asbestos, Crocidolite); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160704
[St] Status:MEDLINE
[do] DOI:10.1111/1753-6405.12542


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[PMID]:27092743
[Au] Autor:Snyder-Talkington BN; Dong C; Porter DW; Ducatman B; Wolfarth MG; Andrew M; Battelli L; Raese R; Castranova V; Guo NL; Qian Y
[Ad] Endereço:a Pathology and Physiology Research Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA.
[Ti] Título:Multiwalled carbon nanotube-induced pulmonary inflammatory and fibrotic responses and genomic changes following aspiration exposure in mice: A 1-year postexposure study.
[So] Source:J Toxicol Environ Health A;79(8):352-66, 2016.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pulmonary exposure to multiwalled carbon nanotubes (MWCNT) induces an inflammatory and rapid fibrotic response, although the long-term signaling mechanisms are unknown. The aim of this study was to examine the effects of 1, 10, 40, or 80 µg MWCNT administered by pharyngeal aspiration on bronchoalveolar lavage (BAL) fluid for polymorphonuclear cell (PMN) infiltration, lactate dehydrogenase (LDH) activity, and lung histopathology for inflammatory and fibrotic responses in mouse lungs 1 mo, 6 mo, and 1 yr postexposure. Further, a 120-µg crocidolite asbestos group was incorporated as a positive control for comparative purposes. Results showed that MWCNT increased BAL fluid LDH activity and PMN infiltration in a dose-dependent manner at all three postexposure times. Asbestos exposure elevated LDH activity at all 3 postexposure times and PMN infiltration at 1 mo and 6 mo postexposure. Pathological changes in the lung, the presence of MWCNT or asbestos, and fibrosis were noted at 40 and 80 µg MWCNT and in asbestos-exposed mice at 1 yr postexposure. To determine potential signaling pathways involved with MWCNT-associated pathological changes in comparison to asbestos, up- and down-regulated gene expression was determined in lung tissue at 1 yr postexposure. Exposure to MWCNT tended to favor those pathways involved in immune responses, specifically T-cell responses, whereas exposure to asbestos tended to favor pathways involved in oxygen species production, electron transport, and cancer. Data indicate that MWCNT are biopersistent in the lung and induce inflammatory and fibrotic pathological alterations similar to those of crocidolite asbestos, but may reach these endpoints by different mechanisms.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Asbesto Crocidolita/toxicidade
Exposição por Inalação
Pulmão/efeitos dos fármacos
Pulmão/patologia
Nanotubos de Carbono/toxicidade
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/química
Relação Dose-Resposta a Droga
Expressão Gênica/efeitos dos fármacos
Inflamação/induzido quimicamente
Inflamação/imunologia
Inflamação/patologia
L-Lactato Desidrogenase/genética
L-Lactato Desidrogenase/metabolismo
Pulmão/imunologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Infiltração de Neutrófilos/efeitos dos fármacos
Neutrófilos/efeitos dos fármacos
Neutrófilos/metabolismo
Fibrose Pulmonar/induzido quimicamente
Fibrose Pulmonar/imunologia
Fibrose Pulmonar/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Nanotubes, Carbon); 12001-28-4 (Asbestos, Crocidolite); EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2016.1159635


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[PMID]:26839332
[Au] Autor:Frank EA; Carreira VS; Birch ME; Yadav JS
[Ad] Endereço:Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
[Ti] Título:Carbon Nanotube and Asbestos Exposures Induce Overlapping but Distinct Profiles of Lung Pathology in Non-Swiss Albino CF-1 Mice.
[So] Source:Toxicol Pathol;44(2):211-25, 2016 Feb.
[Is] ISSN:1533-1601
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carbon nanotubes (CNTs) are emerging as important occupational and environmental toxicants owing to their increasing prevalence and potential to be inhaled as airborne particles. CNTs are a concern because of their similarities to asbestos, which include fibrous morphology, high aspect ratio, and biopersistence. Limitations in research models have made it difficult to experimentally ascertain the risk of CNT exposures to humans and whether these may lead to lung diseases classically associated with asbestos, such as mesothelioma and fibrosis. In this study, we sought to comprehensively compare profiles of lung pathology in mice following repeated exposures to multiwall CNTs or crocidolite asbestos (CA). We show that both exposures resulted in granulomatous inflammation and increased interstitial collagen; CA exposures caused predominantly bronchoalveolar hyperplasia, whereas CNT exposures caused alveolar hyperplasia of type II pneumocytes (T2Ps). T2Ps isolated from CNT-exposed lungs were found to have upregulated proinflammatory genes, including interleukin 1ß (IL-1ß), in contrast to those from CA exposed. Immunostaining in tissue showed that while both toxicants increased IL-1ß protein expression in lung cells, T2P-specific IL-1ß increases were greater following CNT exposure. These results suggest related but distinct mechanisms of action by CNTs versus asbestos which may lead to different outcomes in the 2 exposure types.
[Mh] Termos MeSH primário: Asbesto Crocidolita/toxicidade
Exposição por Inalação/análise
Pulmão/efeitos dos fármacos
Nanotubos de Carbono/toxicidade
Pneumonia
[Mh] Termos MeSH secundário: Células Epiteliais Alveolares/citologia
Células Epiteliais Alveolares/patologia
Animais
Apoptose
Histocitoquímica
Pulmão/citologia
Pulmão/diagnóstico por imagem
Pulmão/patologia
Masculino
Camundongos
Pneumonia/diagnóstico por imagem
Pneumonia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Nanotubes, Carbon); 12001-28-4 (Asbestos, Crocidolite)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160204
[St] Status:MEDLINE
[do] DOI:10.1177/0192623315620587


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[PMID]:26822244
[Au] Autor:Miscetti G; Bodo P; Lumare A; Abbritti EP; Garofani P; Burani V
[Ad] Endereço:AZIENDA UNITA' SANTARIA REGIONE UMBRIA N.1 Perugia. miscetti@libero.it.
[Ti] Título:[Asbestos exposure assessment in the first case of intrasplenic mesothelioma].
[Ti] Título:Accertamento dell'esposizione ad amianto nel primo caso di mesothelioma splenico..
[So] Source:Med Lav;107(1):29-36, 2016 Jan 20.
[Is] ISSN:0025-7818
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:BACKGROUND: In 2013 the International Journal of Surgical Pathology published a case report of intrasplenic malignant mesothelioma (MM) in a 48-year-old man: it was the first report in literature describing a case of primitive intra-splenic MM, described without  a history of asbestos exposure. OBJECTIVE: To verify the possible past exposure to asbestos, ignored by the patient himself, by studying in depth his environmental and occupational history. METHODS: Information about the occupational and non-occupational history of the subject was collected by Experts of the Operational Unit of Occupational Health and Safety Control (UOC PSAL) of the Local Health Unit Umbria 1 - Perugia, using the Italian National Mesothelioma Register (ReNaM) questionnaire and guide lines; an inspection was  carried out at the past canning industry where the patient worked in the period 1982-1990 and material was taken to be analysed by MOCF and SEM. RESULTS: Samples showed the presence of asbestos  fibres belonging to the amphibole class (amosite and crocidolite) and to the serpentine class (chrysotile). CONCLUSIONS: The survey described the past occupational exposure to asbestos in a canning industry, where  the subject worked in the period 1982-1990,  unknown to the patient himself. The authors strongly confirm the  usefulness of standardized methods, such as the ReNaM Questionnaire, and the importance of technical expertise of the investigator to find and analyse the suspect materials and to demonstrate  possible past occupational exposure to asbestos.
[Mh] Termos MeSH primário: Asbestos/efeitos adversos
Carcinógenos
Embalagem de Alimentos
Neoplasias Pulmonares/etiologia
Anamnese
Mesotelioma/etiologia
Neoplasias Esplênicas/etiologia
[Mh] Termos MeSH secundário: Amianto Amosita/efeitos adversos
Asbesto Crocidolita/efeitos adversos
Asbestos Serpentinas/efeitos adversos
Seres Humanos
Neoplasias Pulmonares/diagnóstico
Masculino
Mesotelioma/diagnóstico
Meia-Idade
Medição de Risco
Neoplasias Esplênicas/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Serpentine); 0 (Carcinogens); 12001-28-4 (Asbestos, Crocidolite); 12172-73-5 (Asbestos, Amosite); 1332-21-4 (Asbestos)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160129
[Lr] Data última revisão:
160129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE


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[PMID]:26715106
[Au] Autor:Gilham C; Rake C; Burdett G; Nicholson AG; Davison L; Franchini A; Carpenter J; Hodgson J; Darnton A; Peto J
[Ad] Endereço:London School of Hygiene and Tropical Medicine, London, UK.
[Ti] Título:Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden.
[So] Source:Occup Environ Med;73(5):290-9, 2016 May.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We have conducted a population-based study of pleural mesothelioma patients with occupational histories and measured asbestos lung burdens in occupationally exposed workers and in the general population. The relationship between lung burden and risk, particularly at environmental exposure levels, will enable future mesothelioma rates in people born after 1965 who never installed asbestos to be predicted from their asbestos lung burdens. METHODS: Following personal interview asbestos fibres longer than 5 µm were counted by transmission electron microscopy in lung samples obtained from 133 patients with mesothelioma and 262 patients with lung cancer. ORs for mesothelioma were converted to lifetime risks. RESULTS: Lifetime mesothelioma risk is approximately 0.02% per 1000 amphibole fibres per gram of dry lung tissue over a more than 100-fold range, from 1 to 4 in the most heavily exposed building workers to less than 1 in 500 in most of the population. The asbestos fibres counted were amosite (75%), crocidolite (18%), other amphiboles (5%) and chrysotile (2%). CONCLUSIONS: The approximate linearity of the dose-response together with lung burden measurements in younger people will provide reasonably reliable predictions of future mesothelioma rates in those born since 1965 whose risks cannot yet be seen in national rates. Burdens in those born more recently will indicate the continuing occupational and environmental hazards under current asbestos control regulations. Our results confirm the major contribution of amosite to UK mesothelioma incidence and the substantial contribution of non-occupational exposure, particularly in women.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/efeitos adversos
Neoplasias Pulmonares/induzido quimicamente
Pulmão
Mesotelioma/induzido quimicamente
Doenças Profissionais/induzido quimicamente
Exposição Ocupacional/efeitos adversos
Neoplasias Pleurais/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Idoso
Amianto Amosita/efeitos adversos
Amianto Amosita/análise
Amiantos Anfibólicos/análise
Asbesto Crocidolita/efeitos adversos
Asbesto Crocidolita/análise
Asbestos Serpentinas/efeitos adversos
Asbestos Serpentinas/análise
Asbestose/complicações
Emprego
Feminino
Seres Humanos
Pulmão/química
Pulmão/patologia
Neoplasias Pulmonares/patologia
Masculino
Mesotelioma/patologia
Meia-Idade
Fibras Minerais/efeitos adversos
Fibras Minerais/análise
Doenças Profissionais/patologia
Neoplasias Pleurais/patologia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Asbestos, Amphibole); 0 (Asbestos, Serpentine); 0 (Mineral Fibers); 12001-28-4 (Asbestos, Crocidolite); 12172-73-5 (Asbestos, Amosite)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151231
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2015-103074


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[PMID]:26705886
[Au] Autor:Gandolfi NB; Gualtieri AF; Pollastri S; Tibaldi E; Belpoggi F
[Ad] Endereço:Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, I-41125 Modena, Italy.
[Ti] Título:Assessment of asbestos body formation by high resolution FEG-SEM after exposure of Sprague-Dawley rats to chrysotile, crocidolite, or erionite.
[So] Source:J Hazard Mater;306:95-104, 2016 Apr 05.
[Is] ISSN:1873-3336
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This work presents a comparative FEG-SEM study of the morphological and chemical characteristics of both asbestos bodies and fibres found in the tissues of Sprague-Dawley rats subjected to intraperitoneal or intrapleural injection of UICC chrysotile, UICC crocidolite and erionite from Jersey, Nevada (USA), with monitoring up to 3 years after exposure. Due to unequal dosing based on number of fibres per mass for chrysotile with respect to crocidolite and erionite, excessive fibre burden and fibre aggregation during injection that especially for chrysotile would likely not represent what humans would be exposed to, caution must be taken in extrapolating our results based on instillation in experimental animals to human inhalation. Notwithstanding, the results of this study may help to better understand the mechanism of formation of asbestos bodies. For chrysotile and crocidolite, asbestos bodies are systematically formed on long asbestos fibres. The number of coated fibres is only 3.3% in chrysotile inoculated tissues. In UICC crocidolite, Mg, Si, and Fe are associated with the fibres whereas Fe, P and Ca are associated with the coating. Even for crocidolite, most of the observed fibres are uncoated as coated fibres are about 5.7%. Asbestos bodies do not form on erionite fibres. The crystal habit, crystallinity and chemistry of all fibre species do not change with contact time, with the exception of chrysotile which shows signs of leaching of Mg. A model for the formation of asbestos bodies from mineral fibres is postulated. Because the three fibre species show limited signs of dissolution in the tissue, they cannot act as source of elements (primarily Fe, P and Ca) promoting nucleation and growth of asbestos bodies. Hence, the limited number of coated fibres should be due to the lack of nutrients or organic nature.
[Mh] Termos MeSH primário: Asbesto Crocidolita/farmacocinética
Asbestos Serpentinas/farmacocinética
Zeolitas/farmacocinética
[Mh] Termos MeSH secundário: Animais
Feminino
Injeções Intraperitoneais
Masculino
Microscopia Eletrônica de Varredura
Peritônio/metabolismo
Peritônio/ultraestrutura
Cavidade Pleural/metabolismo
Cavidade Pleural/ultraestrutura
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Asbestos, Serpentine); 12001-28-4 (Asbestos, Crocidolite); 12510-42-8 (erionite); 1318-02-1 (Zeolites)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151227
[St] Status:MEDLINE


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[PMID]:26678224
[Au] Autor:Pietrofesa RA; Velalopoulou A; Arguiri E; Menges CW; Testa JR; Hwang WT; Albelda SM; Christofidou-Solomidou M
[Ti] Título:Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.
[So] Source:Carcinogenesis;37(2):177-87, 2016 Feb.
[Is] ISSN:1460-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Malignant mesothelioma (MM), linked to asbestos exposure, is a highly lethal form of thoracic cancer with a long latency period, high mortality and poor treatment options. Chronic inflammation and oxidative tissue damage caused by asbestos fibers are linked to MM development. Flaxseed lignans, enriched in secoisolariciresinol diglucoside (SDG), have antioxidant, anti-inflammatory and cancer chemopreventive properties. As a prelude to chronic chemoprevention studies for MM development, we tested the ability of flaxseed lignan component (FLC) to prevent acute asbestos-induced inflammation in MM-prone Nf2(+/mu) mice. Mice (n = 16-17 per group) were placed on control (CTL) or FLC-supplemented diets initiated 7 days prior to a single intraperitoneal bolus of 400 µg of crocidolite asbestos. Three days post asbestos exposure, mice were evaluated for abdominal inflammation, proinflammatory/profibrogenic cytokine release, WBC gene expression changes and oxidative and nitrosative stress in peritoneal lavage fluid (PLF). Asbestos-exposed mice fed CTL diet developed acute inflammation, with significant (P < 0.0001) elevations in WBCs and proinflammatory/profibrogenic cytokines (IL-1ß, IL-6, TNFα, HMGB1 and active TGFß1) relative to baseline (BL) levels. Alternatively, asbestos-exposed FLC-fed mice had a significant (P < 0.0001) decrease in PLF WBCs and proinflammatory/profibrogenic cytokine levels relative to CTL-fed mice. Importantly, PLF WBC gene expression of cytokines (IL-1ß, IL-6, TNFα, HMGB1 and TGFß1) and cytokine receptors (TNFαR1 and TGFßR1) were also downregulated by FLC. FLC also significantly (P < 0.0001) blunted asbestos-induced nitrosative and oxidative stress. FLC reduces acute asbestos-induced peritoneal inflammation, nitrosative and oxidative stress and may thus prove to be a promising agent in the chemoprevention of MM.
[Mh] Termos MeSH primário: Asbesto Crocidolita/toxicidade
Butileno Glicóis/administração & dosagem
Glucosídeos/administração & dosagem
Inflamação/patologia
Lignanas/administração & dosagem
Peritônio/patologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Cromatografia Líquida
Dieta
Suplementos Nutricionais
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Linho
Mesotelioma/patologia
Camundongos
Camundongos Mutantes
Estresse Oxidativo/efeitos dos fármacos
Lavagem Peritoneal
Peritônio/efeitos dos fármacos
Lesões Pré-Cancerosas/tratamento farmacológico
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Sementes
Espectrometria de Massas em Tandem
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antioxidants); 0 (Butylene Glycols); 0 (Glucosides); 0 (Lignans); 12001-28-4 (Asbestos, Crocidolite); T9281L29MV (secoisolariciresinol diglucoside)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151219
[St] Status:MEDLINE
[do] DOI:10.1093/carcin/bgv174



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