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[PMID]: 28288687 [Au] Autor: Lavon O; Avrahami A; Eisenkraft A [Ad] Endereço: Clinical Pharmacology and Toxicology Unit, Carmel Medical Center, 7 Michal St., Haifa, 3436212, Israel. ophir.lavon@clalit.org.il. [Ti] Título: Effectiveness of isosorbide dinitrate in cyanide poisoning as a function of the administration timing. [So] Source: BMC Pharmacol Toxicol;18(1):13, 2017 Mar 14. [Is] ISSN: 2050-6511 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Better and safer antidotes against cyanide poisoning are needed. Prior study has shown a favorable effect of isosorbide dinitrate (ISDN) on the survival of cyanide-poisoned rabbits when administered as early as 1 min after poisoning. The aim of the current study was to further evaluate the efficacy of intravenous ISDN administered in clinically relevant timing for first responders. METHODS: A comparative animal study using 24 rabbits in 4 randomized study groups was performed. Animals were poisoned with intravenous potassium cyanide (1 mg/kg). Animals in Group 1 served as controls and received no treatment. Groups 2-4 animals were treated intravenously with ISDN (50 µg/kg) after poisoning; one group after 3 min, another group after 5 min and the last after 7 min. Animals were observed for 30 min after poisoning. The study endpoints included survival rate, clinical status, blood pressure, pulse per minute, blood lactate and pH. RESULTS: Five of 6 animals (83.3%) from every treatment group survived the whole observation period while all control untreated animals died. All the rabbits collapsed immediately after exposure, showing rapidly deteriorated vital signs with lactic metabolic acidosis (peak blood lactate levels of 18.1 to 19.0 mmol/L on average at 10 min post exposure). Vital signs, clinical scores, and blood gases of treated rabbits gradually improved. CONCLUSION: Poisoned rabbits showed improved short-term survival following the administration of ISDN up to 7 min after lethal cyanide poisoning of. We see a potential for ISDN as an antidote against cyanide poisoning. [Mh] Termos MeSH primário: Dinitrato de Isossorbida/administração & dosagem Envenenamento/tratamento farmacológico Cianeto de Potássio/envenenamento [Mh] Termos MeSH secundário: Administração Intravenosa Animais Esquema de Medicação Envenenamento/sangue Envenenamento/mortalidade Cianeto de Potássio/sangue Coelhos Distribuição Aleatória Taxa de Sobrevida/tendências Resultado do Tratamento Vasodilatadores/administração & dosagem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Vasodilator Agents); IA7306519N (Isosorbide Dinitrate); MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171024 [Lr] Data última revisão: 171024 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170315 [St] Status: MEDLINE [do] DOI: 10.1186/s40360-017-0122-0

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[PMID]: 28223243 [Au] Autor: Müller CJ; Quintino-Dos-Santos JW; Schimitel FG; Tufik S; Beijamini V; Canteras NS; Schenberg LC [Ad] Endereço: Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil. [Ti] Título: On the verge of a respiratory-type panic attack: Selective activations of rostrolateral and caudoventrolateral periaqueductal gray matter following short-lasting escape to a low dose of potassium cyanide. [So] Source: Neuroscience;348:228-240, 2017 Apr 21. [Is] ISSN: 1873-7544 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO , it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO . Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior. Accordingly, here we compared the brainstem activations of saline-injected controls (air/saline) with those produced by a single intravenous injection of 40-µg KCN (air/KCN), a 2-min exposure to 13% CO (CO /saline), or a combined stimulus (CO /KCN). Behavioral effects of KCN microinjections into the PAG were assessed as well. Data showed that whereas the KCN microinjections were ineffective, KCN intravenous injections elicited escape in all tested rats. Moreover, whereas the CO alone was ineffective, it potentiated the KCN-evoked escape. Compared to controls, the nucleus tractus solitarius was significantly activated in both CO /saline and CO /KCN groups. Additionally, whereas the laterodorsal tegmental nucleus was activated by all treatments, the rostrolateral and caudoventrolateral PAG were activated by air/KCN only. Data suggest that the latter structures are key components of a hypoxia-sensitive suffocation alarm which activation may trigger a panic attack. [Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos Reação de Fuga/efeitos dos fármacos Neurônios/efeitos dos fármacos Pânico/efeitos dos fármacos Substância Cinzenta Periaquedutal/efeitos dos fármacos Cianeto de Potássio/farmacologia [Mh] Termos MeSH secundário: Animais Masculino Neurônios/metabolismo Substância Cinzenta Periaquedutal/metabolismo Proteínas Proto-Oncogênicas c-fos/metabolismo Ratos Ratos Wistar [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Proto-Oncogene Proteins c-fos); MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170223 [St] Status: MEDLINE

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[PMID]: 28188852 [Au] Autor: Jenkin SE; Milsom WK; Zoccal DB [Ad] Endereço: Department of Zoology, The University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada. Electronic address: jenkin@zoology.ubc.ca. [Ti] Título: The Kölliker-Fuse nucleus acts as a timekeeper for late-expiratory abdominal activity. [So] Source: Neuroscience;348:63-72, 2017 Apr 21. [Is] ISSN: 1873-7544 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: While the transition from the inspiratory to the post-inspiratory (post-I) phase is dependent on the pons, little attention has been paid to understanding the role of the pontine respiratory nuclei, specifically the Kölliker-Fuse nucleus (KF), in transitioning from post-I to the late expiratory (late-E) activity seen with elevated respiratory drive. To elucidate this, we used the in situ working heart-brainstem preparation of juvenile male Holtzman rats and recorded from the vagus (cVN), phrenic (PN) and abdominal nerves (AbN) during baseline conditions and during chemoreflex activation [with potassium cyanide (KCN; n=13) or hypercapnia (8% CO ; n=10)] to recruit active expiration. Chemoreflex activation with KCN increased PN frequency and cVN post-I and AbN activities. The inhibition of KF with isoguvacine microinjections (10mM) attenuated the typical increase in PN frequency and cVN post-I activity, and amplified the AbN response. During hypercapnia, AbN late-E activity emerged in association with a significant reduction in expiratory time. KF inhibition during hypercapnia significantly decreased PN frequency and reduced the duration and amplitude of post-I cVN activity, while the onset of the AbN late-E bursts occurred significantly earlier. Our data reveal a negative relationship between KF-induced post-I and AbN late-E activities, suggesting that the KF coordinates the transition between post-I to late-E activity during conditions of elevated respiratory drive. [Mh] Termos MeSH primário: Abdome/inervação Expiração/fisiologia Hipercapnia/fisiopatologia Inalação/fisiologia Nervo Frênico/fisiologia Nervo Vago/fisiologia [Mh] Termos MeSH secundário: Animais Expiração/efeitos dos fármacos Inalação/efeitos dos fármacos Núcleo de Kölliker-Fuse/fisiologia Masculino Nervo Frênico/efeitos dos fármacos Cianeto de Potássio/farmacologia Ratos Ratos Sprague-Dawley Respiração/efeitos dos fármacos Nervo Vago/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171122 [Lr] Data última revisão: 171122 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170212 [St] Status: MEDLINE

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[PMID]: 28152053 [Au] Autor: Kassouf N; Syed S; Larner J; Amlôt R; Chilcott RP [Ad] Endereço: Research Centre for Topical Drug Delivery and Toxicology, School of Pharmacy, University of Hertfordshire, Hatfield, United Kingdom. [Ti] Título: Evaluation of absorbent materials for use as ad hoc dry decontaminants during mass casualty incidents as part of the UK's Initial Operational Response (IOR). [So] Source: PLoS One;12(2):e0170966, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The UK's Initial Operational Response (IOR) is a revised process for the medical management of mass casualties potentially contaminated with hazardous materials. A critical element of the IOR is the introduction of immediate, on-scene disrobing and decontamination of casualties to limit the adverse health effects of exposure. Ad hoc cleansing of the skin with dry absorbent materials has previously been identified as a potential means of facilitating emergency decontamination. The purpose of this study was to evaluate the in vitro oil and water absorbency of a range of materials commonly found in the domestic and clinical environments and to determine the effectiveness of a small, but representative selection of such materials in skin decontamination, using an established ex vivo model. Five contaminants were used in the study: methyl salicylate, parathion, diethyl malonate, phorate and potassium cyanide. In vitro measurements of water and oil absorbency did not correlate with ex vivo measurements of skin decontamination. When measured ex vivo, dry decontamination was consistently more effective than a standard wet decontamination method ("rinse-wipe-rinse") for removing liquid contaminants. However, dry decontamination was ineffective against particulate contamination. Collectively, these data confirm that absorbent materials such as wound dressings and tissue paper provide an effective, generic capability for emergency removal of liquid contaminants from the skin surface, but that wet decontamination should be used for non-liquid contaminants. [Mh] Termos MeSH primário: Descontaminação/métodos Incidentes com Feridos em Massa Absorção Cutânea/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Feminino Malonatos/toxicidade Paration/toxicidade Forato/toxicidade Cianeto de Potássio/toxicidade Salicilatos/toxicidade Suínos Reino Unido [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Malonates); 0 (Salicylates); 3W54X3W9IV (Phorate); 53A58PA183 (diethyl malonate); 61G466064D (Parathion); LAV5U5022Y (methyl salicylate); MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170814 [Lr] Data última revisão: 170814 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170203 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0170966

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[PMID]: 27562775 [Au] Autor: Lawrence JR; Swerhone GD; Kuhlicke U; Neu TR [Ad] Endereço: Environment and Climate Change Canada, 11 Innovation Blvd, Saskatoon, Saskatchewan, S7N 3H5, Canada John.lawrence2@canada.ca. [Ti] Título: In situ evidence for metabolic and chemical microdomains in the structured polymer matrix of bacterial microcolonies. [So] Source: FEMS Microbiol Ecol;92(11), 2016 Nov. [Is] ISSN: 1574-6941 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: CLSM and fluorescent probes were applied to assess the structure, composition, metabolic activity and gradients within naturally occurring ß-proteobacteria microcolonies. Extracellular polymeric substances (EPS) as defined by lectin-binding analyses had three regions: (i) cell associated, (ii) intercellular and (iii) an outer layer covering the entire colony. We assessed structural, microenvironmental and metabolic implications of this complex EPS structure. Permeability studies indicated that the outer two layers were permeable to 20 nm beads, intercellular EPS to <40 nm beads and the outer layer was permeable to <100 nm beads. Phosphatase activity occurred at the cell surface and associated polymer. Glucose oxidase activity was only detected inside the cells and the cell-associated polymer. Rhodamine 123 suggested that activity was highest near the cell surface. The potential sensitive dye JC-1 concentrated within the outer EPS layer and the gradient was responsive to inhibition by KCN, dispersion using KCl and enhanced by addition of nutrients (nutrient broth). pH gradients occurred from the cell interior (pH 7) to the microcolony interior (pH 4+) with a gradient of increasing pH (pH 7+) to the colony exterior. The EPS provides a physical and chemical structuring mechanism forming microdomains that segregate extracellular activities at the microscale, possibly resulting in a microcolony with unitary structure and function. [Mh] Termos MeSH primário: Betaproteobacteria/metabolismo Membrana Celular/química Microambiente Celular/fisiologia Microdomínios da Membrana/química [Mh] Termos MeSH secundário: Betaproteobacteria/enzimologia Betaproteobacteria/fisiologia Biofilmes/crescimento & desenvolvimento Corantes Fluorescentes Microscopia Confocal Monoéster Fosfórico Hidrolases/metabolismo Polímeros/química Cianeto de Potássio/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Fluorescent Dyes); 0 (Polymers); EC 3.1.3.2 (Phosphoric Monoester Hydrolases); MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160827 [St] Status: MEDLINE

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[PMID]: 27306670 [Au] Autor: Oliveira LM; Moreira TS; Kuo FS; Mulkey DK; Takakura AC [Ad] Endereço: Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil; [Ti] Título: α1- and α2-adrenergic receptors in the retrotrapezoid nucleus differentially regulate breathing in anesthetized adult rats. [So] Source: J Neurophysiol;116(3):1036-48, 2016 Sep 01. [Is] ISSN: 1522-1598 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Norepinephrine (NE) is a potent modulator of breathing that can increase/decrease respiratory activity by α1-/α2-adrenergic receptor (AR) activation, respectively. The retrotrapezoid nucleus (RTN) is known to contribute to central chemoreception, inspiration, and active expiration. Here we investigate the sources of catecholaminergic inputs to the RTN and identify respiratory effects produced by activation of ARs in this region. By injecting the retrograde tracer Fluoro-Gold into the RTN, we identified back-labeled catecholaminergic neurons in the A7 region. In urethane-anesthetized, vagotomized, and artificially ventilated male Wistar rats unilateral injection of NE or moxonidine (α2-AR agonist) blunted diaphragm muscle activity (DiaEMG) frequency and amplitude, without changing abdominal muscle activity. Those inhibitory effects were reduced by preapplication of yohimbine (α2-AR antagonist) into the RTN. Conversely, unilateral RTN injection of phenylephrine (α1-AR agonist) increased DiaEMG amplitude and frequency and facilitated active expiration. This response was blocked by prior RTN injection of prazosin (α1-AR antagonist). Interestingly, RTN injection of propranolol (ß-AR antagonist) had no effect on respiratory inhibition elicited by applications of NE into the RTN; however, the combined blockade of α2- and ß-ARs (coapplication of propranolol and yohimbine) revealed an α1-AR-dependent excitatory response to NE that resulted in increase in DiaEMG frequency and facilitation of active expiration. However, blockade of α1-, α2-, or ß-ARs in the RTN had minimal effect on baseline respiratory activity, on central or peripheral chemoreflexes. These results suggest that NE signaling can modulate RTN chemoreceptor function; however, endogenous NE signaling does not contribute to baseline breathing or the ventilatory response to central or peripheral chemoreceptor activity in urethane-anesthetized rats. [Mh] Termos MeSH primário: Anestesia Células Quimiorreceptoras/fisiologia Receptores Adrenérgicos alfa 1/metabolismo Receptores Adrenérgicos alfa 2/metabolismo Respiração Centro Respiratório/citologia [Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos Adrenérgicos/farmacologia Animais Células Quimiorreceptoras/efeitos dos fármacos Diafragma/fisiologia Inibidores Enzimáticos Masculino Norepinefrina/farmacologia Cianeto de Potássio/farmacologia Ratos Ratos Wistar Respiração/efeitos dos fármacos Centro Respiratório/diagnóstico por imagem Estilbamidinas/metabolismo Vagotomia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt); 0 (Adrenergic Agents); 0 (Enzyme Inhibitors); 0 (Receptors, Adrenergic, alpha-1); 0 (Receptors, Adrenergic, alpha-2); 0 (Stilbamidines); MQD255M2ZO (Potassium Cyanide); X4W3ENH1CV (Norepinephrine) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170908 [Lr] Data última revisão: 170908 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160617 [St] Status: MEDLINE [do] DOI: 10.1152/jn.00023.2016

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[PMID]: 27295522 [Au] Autor: Calegari L; Mozzaquattro BB; Rossato DD; Quagliotto E; Ferreira JB; Rasia-Filho A; Dal Lago P [Ad] Endereço: a Laboratory of Physiology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. [Ti] Título: Exercise training attenuates the pressor response evoked by peripheral chemoreflex in rats with heart failure. [So] Source: Can J Physiol Pharmacol;94(9):979-86, 2016 Sep. [Is] ISSN: 1205-7541 [Cp] País de publicação: Canada [La] Idioma: eng [Ab] Resumo: The effects of exercise training (ExT) on the pressor response elicited by potassium cyanide (KCN) in the rat model of ischemia-induced heart failure (HF) are unknown. We evaluated the effects of ExT on chemoreflex sensitivity and its interaction with baroreflex in rats with HF. Wistar rats were divided into four groups: trained HF (Tr-HF), sedentary HF (Sed-HF), trained sham (Tr-Sham), and sedentary sham (Sed-Sham). Trained animals underwent to a treadmill running protocol for 8 weeks (60 m/day, 5 days/week, 16 m/min). After ExT, arterial pressure (AP), baroreflex sensitivity (BRS), peripheral chemoreflex (KCN: 100 µg/kg body mass), and cardiac function were evaluated. The results demonstrate that ExT induces an improvement in BRS and attenuates the pressor response to KCN relative to the Sed-HF group (P < 0.05). The improvement in BRS was associated with a reduction in the pressor response following ExT in HF rats (P < 0.05). Moreover, ExT induced a reduction in left ventricular end-diastolic pressure and pulmonary congestion compared with the Sed-HF group (P < 0.05). The pressor response to KCN in the hypotensive state is decreased in sedentary HF rats. These results suggest that ExT improves cardiac function and BRS and attenuates the pressor response evoked by KCN in HF rats. [Mh] Termos MeSH primário: Pressão Sanguínea/efeitos dos fármacos Terapia por Exercício Insuficiência Cardíaca/fisiopatologia Insuficiência Cardíaca/terapia Cianeto de Potássio/farmacologia [Mh] Termos MeSH secundário: Animais Barorreflexo/fisiologia Pressão Sanguínea/fisiologia Hiperemia/fisiopatologia Hiperemia/terapia Hipotensão/induzido quimicamente Hipotensão/fisiopatologia Fígado/irrigação sanguínea Pulmão/irrigação sanguínea Masculino Nitroprussiato/farmacologia Ratos Disfunção Ventricular Esquerda/terapia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 169D1260KM (Nitroprusside); MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170523 [Lr] Data última revisão: 170523 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160614 [St] Status: MEDLINE [do] DOI: 10.1139/cjpp-2015-0518

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[PMID]: 27250664 [Au] Autor: Kumano T; Takizawa Y; Shimizu S; Kobayashi M [Ad] Endereço: Institute of Applied Biochemistry, and Graduate School of Life and Environmental Sciences, University of Tsukuba. [Ti] Título: Nitrile-synthesizing enzyme: Gene cloning, overexpression and application for the production of useful compounds. [So] Source: J Gen Appl Microbiol;62(4):174-80, 2016 Sep 12. [Is] ISSN: 1349-8037 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: One of the nitrile-synthesizing enzymes, ß-cyano-L-alanine synthase, catalyzes ß-cyano-L-alanine (ß-CNAla) from potassium cyanide and O-acetyl-L-serine or L-cysteine. We have identified this enzyme from Pseudomonas ovalis No. 111. In this study, we cloned the ß-CNAla synthase gene and expressed it in Escherichia coli and Rhodococcus rhodochrous. Furthermore, we carried out co-expression of ß-CNAla synthase with nitrilase or nitrile hydratases in order to synthesize aspartic acid and asparagine from KCN and O-acetyl-L-serine. This strategy can be used for the synthesis of labeled amino acids by using a carbon-labeled KCN as a substrate, resulting in an application for positron emission tomography. [Mh] Termos MeSH primário: Clonagem Molecular Escherichia coli/genética Liases/genética Liases/metabolismo Nitrilos/metabolismo Pseudomonas/enzimologia Rhodococcus/genética [Mh] Termos MeSH secundário: Alanina/análogos & derivados Alanina/química Alanina/metabolismo Aminoácidos/química Aminoidrolases/genética Asparagina/biossíntese Ácido Aspártico/biossíntese Escherichia coli/metabolismo Expressão Gênica Hidroliases/genética Hidroliases/metabolismo Tomografia por Emissão de Pósitrons Cianeto de Potássio/metabolismo Pseudomonas/genética Rhodococcus/metabolismo Especificidade por Substrato [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amino Acids); 0 (Nitriles); 30KYC7MIAI (Aspartic Acid); 7006-34-0 (Asparagine); 923-01-3 (3-cyanoalanine); EC 3.5.4.- (Aminohydrolases); EC 3.5.5.1 (nitrilase); EC 4.- (Lyases); EC 4.2.1.- (Hydro-Lyases); EC 4.2.1.- (nitrile hydratase); EC 4.4.1.9 (beta-cyanoalanine synthase); MQD255M2ZO (Potassium Cyanide); OF5P57N2ZX (Alanine) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170412 [Lr] Data última revisão: 170412 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160603 [St] Status: MEDLINE [do] DOI: 10.2323/jgam.2016.02.004

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[PMID]: 27237424 [Au] Autor: Irazusta V; Michel L; de Figueroa LI [Ad] Endereço: PROIMI-CONICET, Tucumán, Argentina; INIQUI-CONICET-UNSa, Salta, Argentina. Electronic address: irazustaveronica@gmail.com. [Ti] Título: [Biomineralization of copper in Candida fukuyamaensis RCL-3]. [Ti] Título: Biomineralización de cobre en Candida fukuyamaensis RCL-3.. [So] Source: Rev Argent Microbiol;48(2):166-70, 2016 Apr-Jun. [Is] ISSN: 0325-7541 [Cp] País de publicação: Argentina [La] Idioma: spa [Ab] Resumo: Candida fukuyamaensis RCL-3 yeast has the ability to decrease copper concentration in a culture medium. High copper concentrations change the cell color from white/cream to brown. The effect of color change ceases with the addition of KCN or when cells are grown in a culture medium without sulfate ions. These results could be associated with CuS bioaccumulation in the cell surface. This report revealed that mineralization would be a mechanism used by this yeast for copper bioremediation. [Mh] Termos MeSH primário: Candida/metabolismo Cobre/metabolismo [Mh] Termos MeSH secundário: Biodegradação Ambiental Biotransformação Candida/efeitos dos fármacos Cor Sulfato de Cobre/metabolismo Cristalização Meios de Cultura/metabolismo Cianeto de Potássio/farmacologia Sulfatos/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Culture Media); 0 (Sulfates); 789U1901C5 (Copper); LRX7AJ16DT (Copper Sulfate); MQD255M2ZO (Potassium Cyanide) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170403 [Lr] Data última revisão: 170403 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160531 [St] Status: MEDLINE

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[PMID]: 26877209 [Au] Autor: Jiang J; Chan A; Ali S; Saha A; Haushalter KJ; Lam WL; Glasheen M; Parker J; Brenner M; Mahon SB; Patel HH; Ambasudhan R; Lipton SA; Pilz RB; Boss GR [Ad] Endereço: Department of Medicine, University of California San Diego, La Jolla, California, USA. [Ti] Título: Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. [So] Source: Sci Rep;6:20831, 2016 Feb 15. [Is] ISSN: 2045-2322 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Hydrogen sulfide is a highly toxic gas-second only to carbon monoxide as a cause of inhalational deaths. Its mechanism of toxicity is only partially known, and no specific therapy exists for sulfide poisoning. We show in several cell types, including human inducible pluripotent stem cell (hiPSC)-derived neurons, that sulfide inhibited complex IV of the mitochondrial respiratory chain and induced apoptosis. Sulfide increased hydroxyl radical production in isolated mouse heart mitochondria and F2-isoprostanes in brains and hearts of mice. The vitamin B12 analog cobinamide reversed the cellular toxicity of sulfide, and rescued Drosophila melanogaster and mice from lethal exposures of hydrogen sulfide gas. Cobinamide worked through two distinct mechanisms: direct reversal of complex IV inhibition and neutralization of sulfide-generated reactive oxygen species. We conclude that sulfide produces a high degree of oxidative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for sulfide poisoning. [Mh] Termos MeSH primário: Antídotos/farmacologia Cobamidas/farmacologia Sulfeto de Hidrogênio/toxicidade Neurônios/efeitos dos fármacos Cianeto de Potássio/toxicidade Sulfetos/toxicidade [Mh] Termos MeSH secundário: Animais Apoptose Encéfalo/efeitos dos fármacos Encéfalo/metabolismo Diferenciação Celular Drosophila melanogaster Complexo IV da Cadeia de Transporte de Elétrons/metabolismo F2-Isoprostanos/antagonistas & inibidores F2-Isoprostanos/metabolismo Fibroblastos/citologia Fibroblastos/efeitos dos fármacos Fibroblastos/metabolismo Seres Humanos Sulfeto de Hidrogênio/antagonistas & inibidores Radical Hidroxila/antagonistas & inibidores Radical Hidroxila/metabolismo Células-Tronco Pluripotentes Induzidas/citologia Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos Células-Tronco Pluripotentes Induzidas/metabolismo Masculino Camundongos Camundongos Endogâmicos C57BL Mitocôndrias Cardíacas/efeitos dos fármacos Mitocôndrias Cardíacas/metabolismo Miocárdio/metabolismo Neurônios/citologia Neurônios/metabolismo Estresse Oxidativo Cianeto de Potássio/antagonistas & inibidores Ratos Sulfetos/antagonistas & inibidores [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. [Nm] Nome de substância: 0 (Antidotes); 0 (Cobamides); 0 (F2-Isoprostanes); 0 (Sulfides); 13497-85-3 (cobinamide); 3352-57-6 (Hydroxyl Radical); EC 1.9.3.1 (Electron Transport Complex IV); FWU2KQ177W (sodium bisulfide); MQD255M2ZO (Potassium Cyanide); YY9FVM7NSN (Hydrogen Sulfide) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160216 [St] Status: MEDLINE [do] DOI: 10.1038/srep20831

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