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Pesquisa : D01.640 [Categoria DeCS]
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[PMID]:26907233
[Au] Autor:Zhang X; Pápai M; Møller KB; Zhang J; Canton SE
[Ad] Endereço:X-ray Sciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. xyzhang@aps.anl.gov.
[Ti] Título:Characterizing the Solvated Structure of Photoexcited [Os(terpy)2](2+) with X-ray Transient Absorption Spectroscopy and DFT Calculations.
[So] Source:Molecules;21(2):235, 2016 Feb 19.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Characterizing the geometric and electronic structures of individual photoexcited dye molecules in solution is an important step towards understanding the interfacial properties of photo-active electrodes. The broad family of "red sensitizers" based on osmium(II) polypyridyl compounds often undergoes small photo-induced structural changes which are challenging to characterize. In this work, X-ray transient absorption spectroscopy with picosecond temporal resolution is employed to determine the geometric and electronic structures of the photoexcited triplet state of [Os(terpy)2](2+) (terpy: 2,2':6',2″-terpyridine) solvated in methanol. From the EXAFS analysis, the structural changes can be characterized by a slight overall expansion of the first coordination shell [OsN6]. DFT calculations supports the XTA results. They also provide additional information about the nature of the molecular orbitals that contribute to the optical spectrum (with TD-DFT) and the near-edge region of the X-ray spectra.
[Mh] Termos MeSH primário: Corantes/química
Substâncias Macromoleculares/química
Compostos de Ósmio/química
Soluções/química
[Mh] Termos MeSH secundário: Eletrodos
Estrutura Molecular
Teoria Quântica
Espectroscopia por Absorção de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Macromolecular Substances); 0 (Osmium Compounds); 0 (Solutions)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE


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[PMID]:26491831
[Au] Autor:Ekengard E; Glans L; Cassells I; Fogeron T; Govender P; Stringer T; Chellan P; Lisensky GC; Hersh WH; Doverbratt I; Lidin S; de Kock C; Smith PJ; Smith GS; Nordlander E
[Ad] Endereço:Inorganic Chemistry Research Group, Chemical Physics, Department of Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden. ebbe.nordlander@chemphys.lu.se.
[Ti] Título:Antimalarial activity of ruthenium(II) and osmium(II) arene complexes with mono- and bidentate chloroquine analogue ligands.
[So] Source:Dalton Trans;44(44):19314-29, 2015 Nov 28.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eight new ruthenium and five new osmium p-cymene half-sandwich complexes have been synthesized, characterized and evaluated for antimalarial activity. All complexes contain ligands that are based on a 4-chloroquinoline framework related to the antimalarial drug chloroquine. Ligands HL(1-8) are salicylaldimine derivatives, where HL(1) = N-(2-((2-hydroxyphenyl)methylimino)ethyl)-7-chloroquinolin-4-amine, and HL(2-8) contain non-hydrogen substituents in the 3-position of the salicylaldimine ring, viz. F, Cl, Br, I, NO2, OMe and (t)Bu for HL(2-8), respectively. Ligand HL(9) is also a salicylaldimine-containing ligand with substitutions in both 3- and 5-positions of the salicylaldimine moiety, i.e. N-(2-((2-hydroxy-3,5-di-tert-butylphenyl)methyl-imino)ethyl)-7-chloroquinolin-4-amine, while HL(10) is N-(2-((1-methyl-1H-imidazol-2-yl)methylamino)ethyl)-7-chloroquinolin-4-amine) The half sandwich metal complexes that have been investigated are [Ru(η(6)-cym)(L(1-8))Cl] (Ru-1-Ru-8, cym = p-cymene), [Os(η(6)-cym)(L(1-3,5,7))Cl] (Os-1-Os-3, Os-5, and Os-7), [M(η(6)-cym)(HL(9))Cl2] (M = Ru, Ru-HL(9); M = Os, Os-HL(9)) and [M(η(6)-cym)(L(10))Cl]Cl (M = Ru, Ru-10; M = Os, Os-10). In complexes Ru-1-Ru-8 and Ru-10, Os-1-Os-3, Os-5 and Os-7 and Os-10, the ligands were found to coordinate as bidentate N,O- and N,N-chelates, while in complexes Ru-HL(9) and Os-HL(9), monodentate coordination of the ligands through the quinoline nitrogen was established. The antimalarial activity of the new ligands and complexes was evaluated against chloroquine sensitive (NF54 and D10) and chloroquine resistant (Dd2) Plasmodium falciparum malaria parasite strains. Coordination of ruthenium and osmium arene moieties to the ligands resulted in lower antiplasmodial activities relative to the free ligands, but the resistance index is better for the ruthenium complexes compared to chloroquine. Overall, osmium complexes appeared to be less active than the corresponding ruthenium complexes.
[Mh] Termos MeSH primário: Antimaláricos/síntese química
Antimaláricos/farmacologia
Cloroquina/análogos & derivados
Cloroquina/farmacologia
Compostos de Ósmio/síntese química
Compostos de Ósmio/farmacologia
Compostos de Rutênio/síntese química
Compostos de Rutênio/farmacologia
[Mh] Termos MeSH secundário: Animais
Cloroquina/síntese química
Ligantes
Modelos Moleculares
Estrutura Molecular
Plasmodium falciparum/efeitos dos fármacos
Relação Estrutura-Atividade
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Ligands); 0 (Osmium Compounds); 0 (Ruthenium Compounds); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151104
[Lr] Data última revisão:
151104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151023
[St] Status:MEDLINE
[do] DOI:10.1039/c5dt02410b


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[PMID]:26190176
[Au] Autor:Paunescu E; Nowak-Sliwinska P; Clavel CM; Scopelliti R; Griffioen AW; Dyson PJ
[Ad] Endereço:Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
[Ti] Título:Anticancer Organometallic Osmium(II)-p-cymene Complexes.
[So] Source:ChemMedChem;10(9):1539-47, 2015 Sep.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for their antiproliferative activity. Three compounds from the series display selectivity toward cancer cells, with moderate cytotoxicity observed against human ovarian carcinoma (A2780) cells, whereas no cytotoxicity was observed on non-cancerous human embryonic kidney (HEK-293) cells and human endothelial (ECRF24) cells. Two of these three cancer-cell-selective compounds induce cell death largely via apoptosis and were also found to disrupt vascularization in the chicken embryo chorioallantoic membrane (CAM) model. Based on these promising properties, these compounds have potential clinical applications.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Compostos Organometálicos/química
Compostos Organometálicos/farmacologia
Compostos de Ósmio/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral/efeitos dos fármacos
Técnicas de Química Sintética
Embrião de Galinha
Membrana Corioalantoide/irrigação sanguínea
Membrana Corioalantoide/efeitos dos fármacos
Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais/métodos
Células Endoteliais/efeitos dos fármacos
Células HEK293/efeitos dos fármacos
Seres Humanos
Monoterpenos/química
Compostos de Ósmio/química
Rutênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Monoterpenes); 0 (Organometallic Compounds); 0 (Osmium Compounds); 1G1C8T1N7Q (4-cymene); 7UI0TKC3U5 (Ruthenium)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150828
[Lr] Data última revisão:
150828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150721
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201500221


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[PMID]:26162681
[Au] Autor:Hearn JM; Romero-Canelón I; Munro AF; Fu Y; Pizarro AM; Garnett MJ; McDermott U; Carragher NO; Sadler PJ
[Ad] Endereço:Warwick Systems Biology Centre, University of Warwick, Coventry CV4 7AL, United Kingdom; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom;
[Ti] Título:Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.
[So] Source:Proc Natl Acad Sci U S A;112(29):E3800-5, 2015 Jul 21.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The organometallic "half-sandwich" compound [Os(η(6)-p-cymene)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6 is 49× more potent than the clinical drug cisplatin in the 809 cancer cell lines that we screened and is a candidate drug for cancer therapy. We investigate the mechanism of action of compound 1 in A2780 epithelial ovarian cancer cells. Whole-transcriptome sequencing identified three missense mutations in the mitochondrial genome of this cell line, coding for ND5, a subunit of complex I (NADH dehydrogenase) in the electron transport chain. ND5 is a proton pump, helping to maintain the coupling gradient in mitochondria. The identified mutations correspond to known protein variants (p.I257V, p.N447S, and p.L517P), not reported previously in epithelial ovarian cancer. Time-series RNA sequencing suggested that osmium-exposed A2780 cells undergo a metabolic shunt from glycolysis to oxidative phosphorylation, where defective machinery, associated with mutations in complex I, could enhance activity. Downstream events, measured by time-series reverse-phase protein microarrays, high-content imaging, and flow cytometry, showed a dramatic increase in mitochondrially produced reactive oxygen species (ROS) and subsequent DNA damage with up-regulation of ATM, p53, and p21 proteins. In contrast to platinum drugs, exposure to this organo-osmium compound does not cause significant apoptosis within a 72-h period, highlighting a different mechanism of action. Superoxide production in ovarian, lung, colon, breast, and prostate cancer cells exposed to three other structurally related organo-Os(II) compounds correlated with their antiproliferative activity. DNA damage caused indirectly, through selective ROS generation, may provide a more targeted approach to cancer therapy and a concept for next-generation metal-based anticancer drugs that combat platinum resistance.
[Mh] Termos MeSH primário: Neoplasias Epiteliais e Glandulares/metabolismo
Compostos Organometálicos/farmacologia
Compostos de Ósmio/farmacologia
Neoplasias Ovarianas/metabolismo
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Cromossomos Humanos/genética
Dano ao DNA/genética
DNA Mitocondrial/genética
Feminino
Perfilação da Expressão Gênica
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Mitocôndrias/genética
Mutação/genética
Fator 2 Relacionado a NF-E2/metabolismo
Neoplasias Epiteliais e Glandulares/tratamento farmacológico
Neoplasias Epiteliais e Glandulares/genética
Neoplasias Epiteliais e Glandulares/patologia
Compostos Organometálicos/química
Compostos Organometálicos/uso terapêutico
Compostos de Ósmio/química
Compostos de Ósmio/uso terapêutico
Neoplasias Ovarianas/tratamento farmacológico
Neoplasias Ovarianas/genética
Neoplasias Ovarianas/patologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/genética
Análise de Sequência de RNA
Fator de Transcrição AP-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Organometallic Compounds); 0 (Osmium Compounds); 0 (Transcription Factor AP-1)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150712
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1500925112


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[PMID]:24989699
[Au] Autor:Okamoto A
[Ad] Endereço:Research Center for Advanced Science & Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904 (Japan). okamoto@chembio.t.u-tokyo.ac.jp.
[Ti] Título:DNA-osmium complexes: recent developments in the operative chemical analysis of DNA epigenetic modifications.
[So] Source:ChemMedChem;9(9):1958-65, 2014 Sep.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The development of a reaction for the detection of one epigenetic modification in a long DNA strand is a chemically and biologically challenging research subject. Herein, we report and discuss the formation of 5-methylcytosine-osmium complexes that are used as the basis for a bisulfite-free chemical assay for DNA methylation analysis. Osmium in the oxidized state reacts with C5-methylated pyrimidines in the presence of a bipyridine ligand to give a stable ternary complex. On the basis of this reaction, an adenine derivative with a tethered bipyridine moiety has been designed for sequence-specific osmium complex formation. Osmium complexation is then achieved by hybridization of a short DNA molecule containing this functional nucleotide to a target DNA sequence and results in the formation of a cross-linked structure. This novel concept of methylation-specific reaction, based on a straightforward chemical process, expands the range of methods available for the analysis of epigenetic modifications. Advantages of the described method include amplification-insensitive detection, 5-hydroxymethylcytosine complexation, and visualization through methylation-specific in situ hybridization.
[Mh] Termos MeSH primário: DNA/química
Epigênese Genética
Epigenômica/métodos
Compostos de Ósmio/química
[Mh] Termos MeSH secundário: Animais
DNA/efeitos dos fármacos
Metilação de DNA/efeitos dos fármacos
Seres Humanos
Compostos de Ósmio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Osmium Compounds); 9007-49-2 (DNA)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140829
[Lr] Data última revisão:
140829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140704
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201402114


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[PMID]:24927493
[Au] Autor:Filak LK; Kalinowski DS; Bauer TJ; Richardson DR; Arion VB
[Ad] Endereço:Institute of Inorganic Chemistry, University of Vienna , Währinger Strasse 42, A-1090 Vienna, Austria.
[Ti] Título:Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.
[So] Source:Inorg Chem;53(13):6934-43, 2014 Jul 07.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, the indoloquinoline backbone and piperazine were combined to prepare indoloquinoline-piperazine hybrids and their ruthenium- and osmium-arene complexes in an effort to generate novel antitumor agents with improved aqueous solubility. In addition, the position of the metal-binding unit was varied, and the effect of these structural alterations on the aqueous solubility and antiproliferative activity of their ruthenium- and osmium-arene complexes was studied. The indoloquinoline-piperazine hybrids L(1-3) were prepared in situ and isolated as six ruthenium and osmium complexes [(η(6)-p-cymene)M(L(1-3))Cl]Cl, where L(1) = 6-(4-methylpiperazin-1-yl)-N-(pyridin-2-yl-methylene)-11H-indolo[3,2-c]quinolin-2-N-amine, M = Ru ([1a]Cl), Os ([1b]Cl), L(2) = 6-(4-methylpiperazin-1-yl)-N-(pyridin-2-yl-methylene)-11H-indolo[3,2-c]quinolin-4-N-amine, M = Ru ([2a]Cl), Os ([2b]Cl), L(3) = 6-(4-methylpiperazin-1-yl)-N-(pyridin-2-yl-methylene)-11H-indolo[3,2-c]quinolin-8-N-amine, M = Ru ([3a]Cl), Os ([3b]Cl). The compounds were characterized by elemental analysis, one- and two-dimensional NMR spectroscopy, ESI mass spectrometry, IR and UV-vis spectroscopy, and single-crystal X-ray diffraction. The antiproliferative activity of the isomeric ruthenium and osmium complexes [1a,b]Cl-[3a,b]Cl was examined in vitro and showed the importance of the position of the metal-binding site for their cytotoxicity. Those complexes containing the metal-binding site located at the position 4 of the indoloquinoline scaffold ([2a]Cl and [2b]Cl) demonstrated the most potent antiproliferative activity. The results provide important insight into the structure-activity relationships of ruthenium- and osmium-arene complexes with indoloquinoline-piperazine hybrid ligands. These studies can be further utilized for the design and development of more potent chemotherapeutic agents.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Metais/química
Compostos de Ósmio/química
Compostos de Ósmio/farmacologia
Piperazinas/química
Compostos de Rutênio/química
Compostos de Rutênio/farmacologia
[Mh] Termos MeSH secundário: Sítios de Ligação
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Modelos Moleculares
Solubilidade
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Metals); 0 (Osmium Compounds); 0 (Piperazines); 0 (Ruthenium Compounds)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140614
[St] Status:MEDLINE
[do] DOI:10.1021/ic500825j


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[PMID]:24169702
[Au] Autor:Tamadon F; Seidel S; Seppelt K
[Ti] Título:Reactions of xenon with iridium- and Osmiumhexafluoride.
[So] Source:Acta Chim Slov;60(3):491-4, 2013.
[Is] ISSN:1318-0207
[Cp] País de publicação:Slovenia
[La] Idioma:eng
[Ab] Resumo:Xenon and Iridiumhexafluoride react at temperatures above room temperature forming XeF+IrF6-. In presence of SbF5 FXe+IrSbF11- is formed. Xenon and Osmiumhexafluoride form in solution a blue charge transfer complex that cannot be isolated as a solid.
[Mh] Termos MeSH primário: Ácido Fluorídrico/química
Irídio/química
Compostos de Ósmio/química
Xenônio/química
[Mh] Termos MeSH secundário: Modelos Químicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Osmium Compounds); 3H3U766W84 (Xenon); 44448S9773 (Iridium); RGL5YE86CZ (Hydrofluoric Acid)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:131030
[Lr] Data última revisão:
131030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131031
[St] Status:MEDLINE


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[PMID]:23037896
[Au] Autor:Mühlgassner G; Bartel C; Schmid WF; Jakupec MA; Arion VB; Keppler BK
[Ad] Endereço:University of Vienna, Institute of Inorganic Chemistry, Währinger Straße 42, A-1090 Vienna, Austria.
[Ti] Título:Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells.
[So] Source:J Inorg Biochem;116:180-7, 2012 Nov.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In an attempt to combine the ability of indolobenzazepines (paullones) to inhibit cyclin-dependent kinases (Cdks) and that of platinum-group metal ions to interact with proteins and DNA, ruthenium(II) and osmium(II) arene complexes with paullones were prepared, expecting synergies and an increase of solubility of paullones. Complexes with the general formula [M(II)Cl(η(6)-p-cymene)L]Cl, where M=Ru (1, 3) or Os (2, 4), and L=L(1) (1, 2) or L(2) (3, 4), L(1)=N-(9-bromo-7,12-dihydroindolo[3,2-d][1]-benzazepin-6(5H)-yliden-N'-(2-hydroxybenzylidene)azine and L(2)=N-(9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-yl)-N'-[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl-methylene]azinium chloride (L(2)(*)HCl), were now investigated regarding cytotoxicity and accumulation in cancer cells, impact on the cell cycle, capacity of inhibiting DNA synthesis and inducing apoptosis as well as their ability to inhibit Cdk activity. The MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay yielded IC(50) values in the nanomolar to low micromolar range. In accordance with cytotoxicity data, the BrdU assay showed that 1 is the most and 4 the least effective of these compounds regarding inhibition of DNA synthesis. Effects on the cell cycle are minor, although concentration-dependent inhibition of Cdk2/cyclin E activity was observed in cell-free experiments. Induction of apoptosis is most pronounced for complex 1, accompanied by a low fraction of necrotic cells, as observed by annexin V-fluorescein isothiocyanate/propidium iodide staining and flow cytometric analysis.
[Mh] Termos MeSH primário: Benzazepinas/química
Compostos de Ósmio/farmacologia
Compostos de Rutênio/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Neoplasias do Colo/patologia
Seres Humanos
Compostos de Ósmio/química
Compostos de Rutênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzazepines); 0 (Osmium Compounds); 0 (Ruthenium Compounds); 0 (paullone)
[Em] Mês de entrada:1303
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121006
[St] Status:MEDLINE


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[PMID]:22976964
[Au] Autor:Henke H; Kandioller W; Hanif M; Keppler BK; Hartinger CG
[Ad] Endereço:University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, AT-1090 Vienna.
[Ti] Título:Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents.
[So] Source:Chem Biodivers;9(9):1718-27, 2012 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Organometallic Ru(II) compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their M(II)(η(6)-p-cymene) half-sandwich complexes (M = Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis.
[Mh] Termos MeSH primário: Antineoplásicos/química
Compostos Organometálicos/química
Compostos de Ósmio/química
Piridonas/química
Rutênio/química
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Compostos Organometálicos/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (Osmium Compounds); 0 (Pyridones); 7UI0TKC3U5 (Ruthenium)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120915
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201200005


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[PMID]:21203649
[Au] Autor:Ni WX; Man WL; Cheung MT; Sun RW; Shu YL; Lam YW; Che CM; Lau TC
[Ad] Endereço:Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, China.
[Ti] Título:Osmium(VI) complexes as a new class of potential anti-cancer agents.
[So] Source:Chem Commun (Camb);47(7):2140-2, 2011 Feb 21.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A nitridoosmium(VI) complex [Os(VI)(N)(sap)(OH(2))Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Compostos de Ósmio/química
Compostos de Ósmio/farmacologia
[Mh] Termos MeSH secundário: Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Neoplasias/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Osmium Compounds)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:110201
[Lr] Data última revisão:
110201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110105
[St] Status:MEDLINE
[do] DOI:10.1039/c0cc04515b



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