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[PMID]: 29331752 [Au] Autor: Reddy TS; Privér SH; Mirzadeh N; Bhargava SK [Ad] Endereço: Centre for Advanced Materials & Industrial Chemistry (CAMIC), School of Science, RMIT University, GPO BOX 2476, Melbourne 3001, Australia. [Ti] Título: Synthesis of gold(I) phosphine complexes containing the 2-BrC F PPh ligand: Evaluation of anticancer activity in 2D and 3D spheroidal models of HeLa cancer cells. [So] Source: Eur J Med Chem;145:291-301, 2018 Feb 10. [Is] ISSN: 1768-3254 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Newly synthesised mononuclear gold complexes containing the 2-BrC F PPh ligand have been fully characterised and their anticancer activity towards five human tumor [prostate (PC3), glioblastoma (U87MG), cervical (HeLa), fibrosarcoma (HT1080), ovarian (SKOV-3)] and normal human embryonic kidney (Hek-293T) cell lines investigated. Some of the synthesised gold complexes displayed higher cytotoxicity than cisplatin towards PC-3, HeLa and U87MG cells and inhibited the thioredoxin reductase (TrxR) enzyme, which is considered a potential target for new compounds in cancer treatment. The more physiologically relevant tumor spheroid assay demonstrated the superior potency of these gold phosphine complexes in inhibiting the growth of cervical carcinoma cell line HeLa (3D) spheroidal models. The mechanism of cell death was shown to be apoptotic cell death through cell cycle arrest, mitochondrial membrane depolarisation and increased ROS production. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Modelos Biológicos Compostos Organoáuricos/farmacologia Fosfinas/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/síntese química Antineoplásicos/química Morte Celular/efeitos dos fármacos Proliferação Celular/efeitos dos fármacos Células Cultivadas Cristalografia por Raios X Relação Dose-Resposta a Droga Ensaios de Seleção de Medicamentos Antitumorais Células HeLa Seres Humanos Ligantes Modelos Moleculares Estrutura Molecular Compostos Organoáuricos/síntese química Compostos Organoáuricos/química Fosfinas/química Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (2-BrC6F4PPh2); 0 (Antineoplastic Agents); 0 (Ligands); 0 (Organogold Compounds); 0 (Phosphines); FW6947296I (phosphine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180115 [St] Status: MEDLINE

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[PMID]: 28453168 [Au] Autor: Jamshidi F; Ghorbani A; Darvishi S; Davoodzadeh H [Ad] Endereço: Department of Forensic Medicine and Toxicology and Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Iran. [Ti] Título: Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015. [Ti] Título: Badanie profilu laboratoryjnego u pacjentów po zatruciu fosforkiem glinu w poludniowo-zachodnim Iranie w latach 2010­2015.. [So] Source: Arch Med Sadowej Kryminol;66(3):149-157, 2016. [Is] ISSN: 0324-8267 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: Introduction: Aluminium phosphide or rice tablet is one of the most common pesticides around the world. The substance releases phosphine gas in the presence of water, steam or stomach acid which can lead to poisoning. Phosphine poisoning is more about suicide the number of which is increasing day by day. Two-thirds of patients lose their lives. The aim of this study was to evaluate the data on the clinical epidemiology and laboratory changes in patients poisoned with rice tablets. Material and methods: A total of 23 patients poisoned by aluminium phosphide who referred to Ahvaz Razi hospital within the period of 2010-2015 were studied. The data were analyzed using descriptive statistics and statistical tests. Results: The mean age of the patients was 27.2 ±7.3 years and 60.9% of the patients were male. 8.7% of the patients had hyponatremia and 21.7% of the patients had hypokalemia. In the majority of cases the amount of sodium and potassium was normal. 91% of patients had acidosis and serum bicarbonate was reduced in the majority of cases. The average interval between poisoning and admission was 1.48 ±0.76 hours. Conclusions: The pattern to change the electrolytes and other laboratory factors could be a good marker of the severity of the poisoning and the clinical conditions of the patient, which requires more specific research to prove the process. [Mh] Termos MeSH primário: Compostos de Alumínio/envenenamento Praguicidas/envenenamento Fosfinas/envenenamento Envenenamento/patologia Suicídio [Mh] Termos MeSH secundário: Adulto Autopsia Feminino Seres Humanos Irã (Geográfico) Masculino Meia-Idade Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aluminum Compounds); 0 (Pesticides); 0 (Phosphines); E23DR6L59S (aluminum phosphide) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 180126 [Lr] Data última revisão: 180126 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 27776230 [Au] Autor: Wu Y; Su G; Tang S; Liu W; Ma Z; Zheng X; Liu H; Yu H [Ad] Endereço: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China. [Ti] Título: The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. [So] Source: Chemosphere;168:122-130, 2017 Feb. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Tris (2-chloroethyl) phosphate (TCEP), a substitute for brominated flame retardants (FRs) that have been phased out of use, is frequently detected in aqueous environments. However, previous studies on its endocrine disrupting effects have mainly focused on terrestrial mammals. Here, to comprehensively evaluate the potential adverse effects of TCEP on aquatic vertebrates, zebrafish was used as a model to examine developmental phenotypes. The underlying mechanisms of toxicity of TCEP were further explored using in silico and in vivo approaches. In vivo results demonstrated morphologic changes and mortalities of zebrafish when exposed to high concentrations (14,250 and 28,500 µg TCEP/L). In silico results showed that TCEP can bind to and interact with nuclear receptors with different patterns. The combination of in vivo and in silico analyses indicated that receptors can influence each other at the molecular level and that ER, ThR, RXR and RyR were the key receptors influencing the transcriptional pathways. Our results demonstrate that TCEP has adverse effects at relatively low concentrations by affecting key receptors and genes of vertebrates. These results exhibited the need for further studies to evaluate the potential health risks of TCEP to human infants/children due to its high concentration in Chinese rivers (up to 3700 ng/L) and potential for human exposure. [Mh] Termos MeSH primário: Embrião não Mamífero/efeitos dos fármacos Disruptores Endócrinos/toxicidade Retardadores de Chama/toxicidade Fosfinas/toxicidade Receptores Citoplasmáticos e Nucleares/metabolismo Poluentes Químicos da Água/toxicidade Peixe-Zebra [Mh] Termos MeSH secundário: Animais Relação Dose-Resposta a Droga Embrião não Mamífero/anormalidades Embrião não Mamífero/metabolismo Disruptores Endócrinos/análise Disruptores Endócrinos/metabolismo Retardadores de Chama/análise Retardadores de Chama/metabolismo Seres Humanos Simulação de Acoplamento Molecular Fosfinas/análise Fosfinas/metabolismo Ligação Proteica Receptores Citoplasmáticos e Nucleares/genética Transdução de Sinais Poluentes Químicos da Água/análise Poluentes Químicos da Água/metabolismo Peixe-Zebra/embriologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Endocrine Disruptors); 0 (Flame Retardants); 0 (Phosphines); 0 (Receptors, Cytoplasmic and Nuclear); 0 (Water Pollutants, Chemical); 22OAC2MO2S (tris(2-carboxyethyl)phosphine) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 171212 [Lr] Data última revisão: 171212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 28966283 [Au] Autor: Alim NR; Miyazaki S; Shimoda Y; Sugiura M; Nakajima M; Kotani S [Ad] Endereço: Graduate School of Pharmaceutical Sciences, Kumamoto University. [Ti] Título: Asymmetric Aldol/Vinylogous Aldol/Cyclization Reaction Using Phosphine Oxide Catalysts. [So] Source: Chem Pharm Bull (Tokyo);65(10):989-993, 2017. [Is] ISSN: 1347-5223 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: Chiral phosphine oxide sequentially activates silicon tetrachloride and trichlorosilyl enol ethers to facilitate asymmetric aldol/vinylogous aldol reaction of 4-methoxy-3-penten-2-one and conjugated aldehydes in a highly enantioselective fashion, and the subsequent cyclization produced optically active 2,6-disubstituted 2,3-dihydro-4-pyranones bearing stereogenic centers at a remote position in a single operation. [Mh] Termos MeSH primário: Aldeídos/química Fosfinas/química [Mh] Termos MeSH secundário: Catálise Cloretos/química Cristalografia por Raios X Reação de Cicloadição Conformação Molecular Óxidos/química Compostos de Silício/química Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aldehydes); 0 (Chlorides); 0 (Oxides); 0 (Phosphines); 0 (Silicon Compounds); 8C6G962B53 (3-hydroxybutanal); 96L75U0BM3 (silicon tetrachloride); FW6947296I (phosphine) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171003 [St] Status: MEDLINE [do] DOI: 10.1248/cpb.c17-00540

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[PMID]: 28869336 [Au] Autor: Longo G; La-Placa MG; Sessolo M; Bolink HJ [Ad] Endereço: Instituto de Ciencia Molecular, ICMol, Universidad de Valencia, Catedrático José Beltrán, 2, 46980, Paterna, Spain. [Ti] Título: High Photoluminescence Quantum Yields in Organic Semiconductor-Perovskite Composite Thin Films. [So] Source: ChemSusChem;10(19):3788-3793, 2017 Oct 09. [Is] ISSN: 1864-564X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: One of the obstacles towards efficient radiative recombination in hybrid perovskites is a low exciton binding energy, typically in the orders of tens of meV. It has been shown that the use of electron-donor additives can lead to a substantial reduction of the non-radiative recombination in perovskite films. Herein, the approach using small molecules with semiconducting properties, which are candidates to be implemented in future optoelectronic devices, is presented. In particular, highly luminescent perovskite-organic semiconductor composite thin films have been developed, which can be processed from solution in a simple coating step. By tuning the relative concentration of methylammonium lead bromide (MAPbBr ) and 9,9spirobifluoren-2-yl-diphenyl-phosphine oxide (SPPO1), it is possible to achieve photoluminescent quantum yields (PLQYs) as high as 85 %. This is attributed to the dual functions of SPPO1 that limit the grain growth while passivating the perovskite surface. The electroluminescence of these materials was investigated by fabricating multilayer LEDs, where charge injection and transport was found to be severely hindered for the perovskite/SPPO1 material. This was alleviated by partially substituting SPPO1 with a hole-transporting material, 1,3-bis(N-carbazolyl)benzene (mCP), leading to bright electroluminescence. The potential of combining perovskite and organic semiconductors to prepare materials with improved properties opens new avenues for the preparation of simple lightemitting devices using perovskites as the emitter. [Mh] Termos MeSH primário: Compostos de Cálcio/química Luminescência Óxidos/química Fosfinas/química Semicondutores Titânio/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Calcium Compounds); 0 (Oxides); 0 (Phosphines); 12194-71-7 (perovskite); D1JT611TNE (Titanium) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171106 [Lr] Data última revisão: 171106 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170905 [St] Status: MEDLINE [do] DOI: 10.1002/cssc.201701265

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[PMID]: 28692195 [Au] Autor: Ma M; Zhu G; Xie F; Qu F; Liu Z; Du G; Asiri AM; Yao Y; Sun X [Ad] Endereço: College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, Sichuan, PR China. [Ti] Título: Homologous Catalysts Based on Fe-Doped CoP Nanoarrays for High-Performance Full Water Splitting under Benign Conditions. [So] Source: ChemSusChem;10(16):3188-3192, 2017 Aug 24. [Is] ISSN: 1864-564X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The design and development of earth-abundant electrocatalysts for efficient full water splitting under mild conditions are highly desired, yet remain a challenging task. A homologous Fe-doped Co-based nanoarray incorporating complementary catalysts is shown to effect high-performance and durable water splitting in near-neutral media. Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm in 0.1 m potassium borate (K-Bi, pH 9.2). Fe-CoP/CC is also highly active for the hydrogen evolution reaction, capable of driving 10 mA cm at an overpotential of only 175 mV in 0.1 m K-Bi. A two-electrode water electrolyzer incorporating Fe-Co-Pi-Bi/CC as anode and Fe-CoP/CC as cathode achieves 10 mA cm water-splitting current at a cell voltage of 1.95 V with strong long-term electrochemical durability. [Mh] Termos MeSH primário: Ferro/química Nanotecnologia/métodos Fosfinas/química Água/química [Mh] Termos MeSH secundário: Catálise Química Verde [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Phosphines); 0 (cobalt phosphide); 059QF0KO0R (Water); E1UOL152H7 (Iron) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170904 [Lr] Data última revisão: 170904 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170711 [St] Status: MEDLINE [do] DOI: 10.1002/cssc.201700693

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[PMID]: 28444503 [Au] Autor: Kim JW; Seo S; Kim HS; Kim DY; Lee HY; Kang KW; Lee DS; Bom HS; Min JJ; Lee JS [Ad] Endereço: Department of Nuclear Medicine, Seoul National University College of Medicine, Daehak-ro 101, Chongnogu, Seoul, 03080, Korea. [Ti] Título: Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent F-FPTP. [So] Source: Ann Nucl Med;31(6):469-479, 2017 Jul. [Is] ISSN: 1864-6433 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: OBJECTIVE: ( F-fluoropentyl)triphenylphosphonium salt ( F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken. METHODS: F-FPTP dynamic PET (18 min) and CT images were acquired from rats with myocardial infarction (MI) (n = 12). Regions of interest (ROIs) were on the left ventricle, normal myocardium, and MI region. Two-compartment (K and k ; 2C2P) and three-compartment (K -k ; 3C3P) models with irreversible uptake were compared for goodness-of-fit. Partial volume and spillover correction terms (V and α = 1 - V ) were also incorporated. LLS and BFM were applied to ROI- and voxel-based kinetic parameter estimations. Results were compared with the standard ROI-based nonlinear least-squares (NLS) results of the corresponding compartment model. A simulation explored statistical properties of the estimation methods. RESULTS: The 2C2P model was most suitable for describing F-FPTP kinetics. Average K , k , and V values were, respectively, 6.8 (ml/min/g), 1.1 (min ), and 0.44 in normal myocardium and 1.4 (ml/min/g), 1.1 (min ), and 0.32, in MI tissue. Ten minutes of data was sufficient for the estimation. LLS and BFM estimations correlated well with NLS values for the ROI level (K : y = 1.06x + 0.13, r  = 0.96 and y = 1.13x + 0.08, r  = 0.97) and voxel level (K : y = 1.22x - 0.30, r  = 0.90 and y = 1.26x + 0.00, r  = 0.92). Regional distribution of kinetic parametric images (αK , K , k , V ) was physiologically relevant. LLS and BFM showed more robust characteristics than NLS in the simulation. CONCLUSIONS: Fast kinetics and highly specific uptake of F-FPTP by myocardium enabled quantitative analysis with the 2C2P model using only the initial 10 min of data. LLS and BFM were feasible for estimating voxel-wise parameters. These two methods will be useful for quantitative evaluation of F-FPTP distribution in myocardium and in further studies with different conditions, disease models, and species. [Mh] Termos MeSH primário: Coração/diagnóstico por imagem Processamento de Imagem Assistida por Computador Fosfinas Tomografia Computadorizada com Tomografia por Emissão de Pósitrons [Mh] Termos MeSH secundário: Algoritmos Seres Humanos Cinética Modelos Biológicos Fosfinas/metabolismo [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 ((5-fluoropentyl)triphenylphosphonium); 0 (Phosphines) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170427 [St] Status: MEDLINE [do] DOI: 10.1007/s12149-017-1171-6

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[PMID]: 28403354 [Au] Autor: Cardoso KA; Zarpellon DC; Madruga CF; Rodrigues JA; Arrais CA [Ad] Endereço: Universidade Guarulhos, Centro de Pós Graduação e Pesquisa, Guarulhos, SP, Brasil. [Ti] Título: Effects of radiant exposure values using second and third generation light curing units on the degree of conversion of a lucirin-based resin composite. [So] Source: J Appl Oral Sci;25(2):140-146, 2017 Mar-Apr. [Is] ISSN: 1678-7765 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Objective: Using Fourier transform infrared analysis (FTIR) in vitro, the effects of varying radiant exposure (RE) values generated by second and third generation LED LCUs on the degree of conversion (DC) and maximum rate of polymerization (Rpmax) of an experimental Lucirin TPO-based RC were evaluated. Material and Methods: 1 mm or 2 mm thick silicon molds were positioned on a horizontal attenuated total reflectance (ATR) unit attached to an infrared spectroscope. The RC was inserted into the molds and exposed to varying REs (18, 36 and 56 J/cm2) using second (Radii Plus, SDI) and third generation LED LCUs (Bluephase G2/Ivoclar Vivadent) or a quartz tungsten based LCU (Optilux 501/SDS Kerr). FTIR spectra (n=7) were recorded for 10 min (1 spectrum/s, 16 scans/spectrum, resolution 4 cm-1) immediately after their application to the ATR. The DC was calculated using standard techniques for observing changes in aliphatic to aromatic peak ratios both prior to, and 10 min after curing, as well as during each 1 second interval. DC and Rpmax data were analyzed using 3-way ANOVA and Tukey's post-hoc test (p=0.05). Results: No significant difference in DC or Rpmax was observed between the 1 mm or 2 mm thick specimens when RE values were delivered by Optilux 501 or when the 1 mm thick composites were exposed to light emitted by Bluephase G2, which in turn promoted a lower DC when 18 J/cm2 (13 s) were delivered to the 2 mm thick specimens. Radii Plus promoted DC and Rpmax values close to zero under most conditions, while the delivery of 56 J/cm2 (40 s) resulted in low DC values. Conclusions: The third generation LCU provided an optimal polymerization of Lucirin TPO-based RC under most tested conditions, whereas the second generation LED-curing unit was useless regardless of the RE. [Mh] Termos MeSH primário: Resinas Compostas/efeitos da radiação Luzes de Cura Dentária Cura Luminosa de Adesivos Dentários/métodos Fosfinas/efeitos da radiação [Mh] Termos MeSH secundário: Análise de Variância Teste de Materiais Transição de Fase Fotoiniciadores Dentários/química Polimerização/efeitos da radiação Dose de Radiação Valores de Referência Reprodutibilidade dos Testes Espectroscopia de Infravermelho com Transformada de Fourier Fatores de Tempo [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 ((2,4,6-trimethylbenzoyl) diphenylphosphine oxide); 0 (Composite Resins); 0 (Phosphines); 0 (Photoinitiators, Dental) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170530 [Lr] Data última revisão: 170530 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 170414 [St] Status: MEDLINE

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[PMID]: 28383719 [Au] Autor: Konemann CE; Hubhachen Z; Opit GP; Gautam S; Bajracharya NS [Ad] Endereço: Department of Entomology and Plant Pathology, Oklahoma State University, 127 Noble Research Center, Stillwater, OK 74078 (charles.e.konemann@okstate.edu; jorigtoo.chen@okstate.edu; george.opit@okstate.edu; sangautam@ucanr.edu; nisha.shakya10@okstate.edu). [Ti] Título: Phosphine Resistance in Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) Collected From Grain Storage Facilities in Oklahoma, USA. [So] Source: J Econ Entomol;110(3):1377-1383, 2017 Jun 01. [Is] ISSN: 1938-291X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Phosphine gas (PH3) is one of the most commonly used fumigants for controlling stored-grain pests worldwide. We estimated the discriminating dose for Cryptolestes ferrugineus (Stephens) (Coleoptera: Laemophloeidae) adult insects using a laboratory susceptible strain. This discriminating dose was then used to determine presence or absence of PH3 resistance (resistance frequencies) in 19 field-collected populations of C. ferrugineus from Oklahoma, United States. The discriminating dose was estimated as 56.2 ppm of PH3 over a 20-h exposure period at 25 °C. Discriminating dose bioassay results showed that PH3 resistance was present in all 19 populations of C. ferrugineus tested. However, five populations-Stillwater (Stil), Enid Terminal 1 (ET-1), Enid Terminal 2 (ET-2), Johnson-Enid population (JE), and DK Farm 20 population (DK Farm 20) had ≥90% resistance frequencies. LC99 values estimated by probit analyses of dose-response mortality data for the laboratory susceptible strain (Lab-S), JE, and DK Farm 20 were 7.3, 636.4, and 968.6 ppm, respectively, over a 3-d exposure period. The level of resistance in DK Farm 20, the most resistant population, was 133.5 times that of the susceptible laboratory strain. This study shows that PH3 resistance in C. ferrugineus may be widespread in Oklahoma. Based on this study, there is a need for a wider PH3 resistance survey in grain-growing regions of Oklahoma and United States. Furthermore, results show there is a need to develop PH3 resistance management strategies for C. ferrugineus and other stored-product insect pest species to combat resistance and ensure continued effective future use of PH3. [Mh] Termos MeSH primário: Coleópteros/fisiologia Grãos Comestíveis Armazenamento de Alimentos Resistência a Inseticidas Inseticidas/farmacologia Fosfinas/farmacologia [Mh] Termos MeSH secundário: Animais Feminino Masculino Oklahoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insecticides); 0 (Phosphines); FW6947296I (phosphine) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170407 [St] Status: MEDLINE [do] DOI: 10.1093/jee/tox101

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[PMID]: 28369429 [Au] Autor: Cato AJ; Elliott B; Nayak MK; Phillips TW [Ad] Endereço: Department of Entomology, Kansas State University, Manhattan, KS 66506 ( ajcato@email.uark.edu ; twp1@ksu.edu ). [Ti] Título: Geographic Variation in Phosphine Resistance Among North American Populations of the Red Flour Beetle (Coleoptera: Tenebrionidae). [So] Source: J Econ Entomol;110(3):1359-1365, 2017 Jun 01. [Is] ISSN: 1938-291X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The red flour beetle, Tribolium castaneum (Herbst), is a common stored-product pest found worldwide. Phosphine, hydrogen phosphide (PH3), is the most commonly used fumigant for stored grains, for which genetically based resistance has been recorded for several pest species. This study assessed phosphine resistance in 25 T. castaneum populations from across the United States and Canada using a discriminating dose bioassay. Dose-mortality assays were conducted with adults from seven of these populations to categorize weak and strong resistance phenotypes. Phosphine resistance was detected in 12 out of the 25 populations, and the frequency of resistance within populations varied from 2% in Victoria, TX, to 100% in Red Level, AL. Two resistant populations from Kansas that had been sampled three years earlier were found to have similar resistance frequencies in the current study. None of the four Canadian populations had any detectable resistance among the insects tested. Resistance ratio calculations from LC50 value in resistant populations relative to the LC50 for the laboratory susceptible strain allowed resistance phenotypes to be assigned as either weak resistance, at 5- to 26-fold resistance relative to susceptible, or strong resistance at 95- to 127-fold relative to susceptible. This study suggests that proper resistance assessment techniques can help to determine occurrence of phosphine resistance in populations of T. castaneum and can further characterize the strength of resistance present. These data can be used to support resistance management programs that consider either cessation or modification of phosphine fumigation to control T. castaneum. [Mh] Termos MeSH primário: Resistência a Inseticidas Inseticidas/farmacologia Fosfinas/farmacologia Tribolium/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Canadá Relação Dose-Resposta a Droga Geografia Fenótipo Tribolium/genética Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insecticides); 0 (Phosphines); FW6947296I (phosphine) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170915 [Lr] Data última revisão: 170915 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170404 [St] Status: MEDLINE [do] DOI: 10.1093/jee/tox091

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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