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[PMID]:28838591
[Au] Autor:Sheridan K; Logomarsino JV
[Ad] Endereço:Department of Human Environmental Studies, Central Michigan University, Mt. Pleasant, Michigan. Electronic address: Kristinsher@gmail.com.
[Ti] Título:Effects of serum phosphorus on vascular calcification in a healthy, adult population: A systematic review.
[So] Source:J Vasc Nurs;35(3):157-169, 2017 Sep.
[Is] ISSN:1532-6578
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiovascular disease has been associated with elevated serum phosphorus levels, which have been associated with cardiovascular mortality. This is commonly seen in the chronic kidney disease (CKD) population where studies have shown that high phosphorus levels cause coronary artery calcification. Although studies have independently associated vascular stiffness and serum phosphorus in those with and without CKD, there are fewer data in individuals without CKD. Therefore, the aim of this systematic review was to analyze whether serum phosphorus levels are associated with cardiovascular calcification in healthy individuals. A systematic review of the literature that was conducted revealed 10 articles, all cross-sectional studies, that met eligibility criteria. These criteria were peer-reviewed studies on a healthy, adult population written in the English language. Studies lacking data on serum phosphorus and measured to assess its association with vascular calcification were excluded. Studies on subjects with CKD, other chronic diseases, or on children were also excluded. Of the 10 studies located, 8 indicated an association between serum phosphorus and vascular calcification. One study did not indicate an association. One study indicated a statistically significant association between serum phosphorus and vascular calcification prevalence, but not incidence. Studies were limited since no randomized controlled trials were available. This systematic review generates gaps in research. Due to considerable amounts of phosphorus additives in the food supply, there may be a connection to dietary phosphorus and vascular calcification. Additionally, phosphorus binders may assist in the prevention of vascular calcification but have not been studied in a healthy population. Further study on both dietary phosphorus restriction and phosphorus binders is needed. While 8 out of 10 cross-sectional studies found an association in this systematic review, the topic of vascular calcification and serum phosphorus needs further study if a cause and effect relationship is to be detected.
[Mh] Termos MeSH primário: Voluntários Saudáveis
Fósforo na Dieta/sangue
Calcificação Vascular/sangue
[Mh] Termos MeSH secundário: Cálcio na Dieta/sangue
Seres Humanos
Rigidez Vascular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium, Dietary); 0 (Phosphorus, Dietary)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


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[PMID]:28700185
[Au] Autor:Cabibbe M; Montoli A; Cassaro F; Cortesi P; D'Oria R; Izzo M; Grotti M; Manca N; Marino F; Biazzi C; Cingoli G; Colussi G
[Ad] Endereço:ASST Grande Ospedale Metropolitano Niguarda, Milano.
[Ti] Título:[Dialysis and cookers: a project for the empowerment of patients in managing their own chronic renal failure].
[So] Source:G Ital Nefrol;34(3):70-84, 2017 Jun.
[Is] ISSN:1724-5990
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:The phosphate and potassium control is indispensable to dominate the secondary hyperparathyroidism and reduce cardiovascular mortality in dialysis patients. Most of them receive only theoretical nutritional information. We therefore organized a cooking workshop for dialysis patients, with a multidisciplinary team consisting of nurses, nephrologists, a dietitian and a professional chef, to directly teach the patients and their families how to realize a low phosphorus and potassium menu, assessing the proper use of phosphate binders, and blood tests at baseline and at three and six months. Twenty-four patients, out of 133, attended the workshop with a family member, filling out a questionnaire on eating habits, knowledge about phosphorus and potassium, and about binders. Theoretical and practical information about phosphorus and potassium metabolism, about binders, and cooking techniques were given during the evening, we then prepared a meal, eaten all together. The questionnaire was repeated at the end of the evening, and all the participants reported an improvement of the considered variables. Phosphorus and potassium plasma levels and the number of binders did not change after three and six months. Coping with the dietary changes related to the start of the dialytic therapy in an informal atmosphere, with a family member, is highly appreciated, clinically useful, logistically and economically sustainable. A customized and long-lasting counselling is probably required to modify plasma levels of phosphorus and potassium and binder's consumption. The poor dietary knowledge detected in our patients and the satisfaction about the course both confirm the training needs in this area.
[Mh] Termos MeSH primário: Culinária
Falência Renal Crônica/terapia
Educação de Pacientes como Assunto
Diálise Renal
Autocuidado
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Fósforo na Dieta/administração & dosagem
Potássio na Dieta/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphorus, Dietary); 0 (Potassium, Dietary)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28674306
[Au] Autor:Shimoishi K; Anraku M; Uto A; Iohara D; Hirayama F; Kadowaki D; Zingami S; Maruyama T; Otagiri M
[Ad] Endereço:Department of Pharmacy, Japanese Red Cross Kumamoto Hospital.
[Ti] Título:A Comparison of the Phosphorus Content in Prescription Medications for Hemodialysis Patients in Japan.
[So] Source:Yakugaku Zasshi;137(7):903-908, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A high dietary intake of phosphorus is considered to be a significant health threat for hemodialysis (HD) patients. Prescription medications, which might be a major source of phosphorus, is largely unrecognized in Japan. However, the amount of phosphorus indicated on the package label, is not quantified. In this study, the phosphorus content of 22 of the most widely prescribed medications that are used in conjunction with HD therapy were examined and differences between branded and generic prescription medications were compared. All samples were selected from medications that are typically prescribed for HD patients. The samples were ground prior to analysis. Phosphorus was measured using the Wako L-Type Phosphate method. All instruments used in the study were calibrated according to the manufacturers' specifications. Amlodipine (15 mg/tablet) and paroxetine (30.0 mg/tablet) were found to contain higher contents of phosphorus than the medications tested. Differences in phosphorus content between branded and generic drugs was also determined. The phosphorus content of all generic paroxetine preparations was significantly lower than the values for identical branded medications. On the other hand, the phosphorus content of several generic amlodipine preparations were significantly different from those of similar, branded preparations. Specific information regarding the phosphorus content of prescribed medications used by HD patient needs to be made available to the dialysis community.
[Mh] Termos MeSH primário: Fósforo/efeitos adversos
Fósforo/análise
Medicamentos sob Prescrição/química
Diálise Renal
[Mh] Termos MeSH secundário: Anlodipino/química
Medicamentos Genéricos/química
Seres Humanos
Japão
Paroxetina/química
Fósforo na Dieta/efeitos adversos
Fósforo na Dieta/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Generic); 0 (Phosphorus, Dietary); 0 (Prescription Drugs); 1J444QC288 (Amlodipine); 27YLU75U4W (Phosphorus); 41VRH5220H (Paroxetine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00006


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[PMID]:28643620
[Au] Autor:Stockman J; Watson P; Gilham M; Allaway D; Atwal J; Haydock R; Colyer A; Renfrew H; Morris PJ
[Ad] Endereço:1WALTHAM Centre for Pet Nutrition,Waltham-on-the-Wolds,Melton Mowbray,Leicestershire LE14 4RT,UK.
[Ti] Título:Adult dogs are capable of regulating calcium balance, with no adverse effects on health, when fed a high-calcium diet.
[So] Source:Br J Nutr;117(9):1235-1243, 2017 May.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although the implications of long-term high Ca intakes have been well documented in growing dogs, the health consequences of Ca excess in adult dogs remain to be established. To evaluate the impact of feeding a diet containing 7·1 g/4184 kJ (1000 kcal) Ca for 40 weeks on Ca balance and health parameters in adult dogs, eighteen neutered adult Labrador Retrievers, (nine males and nine females) aged 2·5-7·4 years were randomised to one of two customised diets for 40 weeks. The diets were manufactured according to similar nutritional specifications, with the exception of Ca and P levels. The diets provided 1·7 and 7·1 g/4184 kJ (1000 kcal) (200(SD26) and 881(SD145) mg/kg body weight0·75 per d, respectively) Ca, respectively, with a Ca:P ratio of 1·6. Clinical examinations, ultrasound scans, radiographs, health parameters, metabolic effects and mineral balance were recorded at baseline and at 8-week intervals throughout the study. Dogs in both groups were healthy throughout the trial without evidence of urinary, renal or orthopaedic disease. In addition, there were no clinically relevant changes in any of the measures made in either group (all P>0·05). The high-Ca diet resulted in a 3·3-fold increase in faecal Ca excretion (P0·05). Ca intakes of up to 7·1 g/4184 kJ (1000 kcal) are well tolerated over a period of 40 weeks, with no adverse effects that could be attributed to the diet or to a high mineral intake.
[Mh] Termos MeSH primário: Ração Animal/análise
Cálcio na Dieta/administração & dosagem
Cálcio/metabolismo
Dieta/veterinária
Cães/fisiologia
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Digestão
Feminino
Rim/fisiologia
Masculino
Fósforo na Dieta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium, Dietary); 0 (Phosphorus, Dietary); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517001210


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[PMID]:28613982
[Au] Autor:Chang AR; Anderson C
[Ad] Endereço:Kidney Health Research Institute, Geisinger Health System, Danville, Pennsylvania 17822; email: achang@geisinger.edu.
[Ti] Título:Dietary Phosphorus Intake and the Kidney.
[So] Source:Annu Rev Nutr;37:321-346, 2017 Aug 21.
[Is] ISSN:1545-4312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although phosphorus is an essential nutrient required for multiple physiological functions, recent research raises concerns that high phosphorus intake could have detrimental effects on health. Phosphorus is abundant in the food supply of developed countries, occurring naturally in protein-rich foods and as an additive in processed foods. High phosphorus intake can cause vascular and renal calcification, renal tubular injury, and premature death in multiple animal models. Small studies in human suggest that high phosphorus intake may result in positive phosphorus balance and correlate with renal calcification and albuminuria. Although serum phosphorus is strongly associated with cardiovascular disease, progression of kidney disease, and death, limited data exist linking high phosphorus intake directly to adverse clinical outcomes. Further prospective studies are needed to determine whether phosphorus intake is a modifiable risk factor for kidney disease.
[Mh] Termos MeSH primário: Rim/fisiopatologia
Fósforo na Dieta/efeitos adversos
Insuficiência Renal Crônica/etiologia
[Mh] Termos MeSH secundário: Animais
Dieta Ocidental/efeitos adversos
Seres Humanos
Insuficiência Renal Crônica/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phosphorus, Dietary)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-nutr-071816-064607


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[PMID]:28592606
[Au] Autor:Yoon CY; Park JT; Jhee JH; Noh J; Kee YK; Seo C; Lee M; Cha MU; Kim H; Park S; Yun HR; Jung SY; Han SH; Yoo TH; Kang SW
[Ad] Endereço:Department of Medicine, Yonsei University Graduate School of Medicine, Seoul, Republic of Korea.
[Ti] Título:High dietary phosphorus density is a risk factor for incident chronic kidney disease development in diabetic subjects: a community-based prospective cohort study.
[So] Source:Am J Clin Nutr;106(1):311-321, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High serum phosphorus concentrations are associated with an increased risk of cardiovascular disease and progression of chronic kidney disease (CKD). However, the relation between dietary phosphorus intake and CKD development has not been well evaluated. In this study, we investigated the impact of dietary phosphorus density on the development of incident CKD in a cohort of subjects with normal renal function. Data were retrieved from the Korean Genome and Epidemiology Study, a prospective community-based cohort study. The study cohort consisted of subjects aged 40-69 y, who were followed up biennially from 2001 to 2014. A total of 873 subjects with diabetes mellitus (DM) and 5846 subjects without DM (non-DM) were included in the final analysis. The primary endpoint was incident CKD, defined as a composite of estimated glomerular filtration rate <60 mL · min · 1.73 m and/or the development of proteinuria. In the DM and non-DM groups, the mean ages of the participants were 55.6 ± 8.7 and 51.4 ± 8.6 y, the numbers of male subjects were 454 (52.0%) and 2784 (47.6%), and the mean estimated glomerular filtration rates were 91.6 ± 14.0 and 94.5 ± 14.0 mL · min · 1.73 m , respectively. The mean values of dietary phosphorus density, defined as the ratio of a single-day dietary phosphorus amount to the total daily calorie intake, were 0.51 ± 0.08 mg/kcal in the DM group and 0.51 ± 0.07 mg/kcal in the non-DM group. During the follow-up, CKD newly developed in 283 (32.4%) and 792 subjects (13.5%) in the DM and non-DM groups, respectively. When the subjects were divided into quartiles according to the dietary phosphorus density in each group, the highest quartile was significantly associated with the development of incident CKD by multiple Cox proportional hazard analysis in the DM group ( = 0.02) but not in the non-DM group ( = 0.72). High dietary phosphorus density is associated with an increased risk of CKD development in DM patients with normal renal function. The causality in this association needs to be tested in a randomized controlled trial.
[Mh] Termos MeSH primário: Diabetes Mellitus
Nefropatias Diabéticas/etiologia
Ingestão de Energia
Rim/efeitos dos fármacos
Fósforo na Dieta/efeitos adversos
Fósforo/efeitos adversos
Insuficiência Renal Crônica/etiologia
[Mh] Termos MeSH secundário: Diabetes Mellitus/patologia
Dieta
Progressão da Doença
Comportamento Alimentar
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Incidência
Masculino
Meia-Idade
Fósforo/administração & dosagem
Fósforo na Dieta/administração & dosagem
Modelos de Riscos Proporcionais
Estudos Prospectivos
Proteinúria/etiologia
Valores de Referência
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphorus, Dietary); 27YLU75U4W (Phosphorus)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.151654


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[PMID]:28380588
[Au] Autor:Blavi L; Sola-Oriol D; Perez JF; Stein HH
[Ti] Título:Effects of zinc oxide and microbial phytase on digestibility of calcium and phosphorus in maize-based diets fed to growing pigs.
[So] Source:J Anim Sci;95(2):847-854, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An experiment was conducted to test the hypothesis that inclusion of Zn at a pharmacological level in diets fed to pigs affects apparent total tract digestibility (ATTD) of Ca and P and standardized total tract digestibility (STTD) of Ca. The second hypothesis was that inclusion of microbial phytase increases the ATTD of Ca and P and the STTD of Ca regardless of the concentration of Zn in the diet. Fifty-six growing barrows (15.4 ± 1.9 kg average BW) were allotted to a randomized complete block design with 7 dietary treatments and 8 pigs per treatment. A maize-based basal diet was formulated with either 0 or 2,400 mg/kg Zn from ZnO and 0, 1,000, or 3,000 units of phytase (FTU) per kilogram. A Ca-free diet was used to determine basal endogenous losses of Ca. Experimental diets were fed for 13 d, and feces were collected from the feed provided from d 6 to 11 using the marker-to-marker approach; urine was also collected from d 6 to 11. Retention of Ca, ATTD of Ca, and STTD of Ca increased ( < 0.01) as the concentration of phytase in the diet increased and were less ( < 0.01) if ZnO was used than if no ZnO was added to the diet. Retention of P and the ATTD of P increased ( < 0.0001) as the concentration of phytase increased in the diet, but the increase was greater if ZnO was not added than if ZnO was added to the diet (interaction, < 0.05). In conclusion, pharmacological levels of Zn reduced Ca and P digestibility and retention, but this effect was partly ameliorated by the inclusion of phytase in the diets. Inclusion of microbial phytase increased the ATTD and STTD of Ca in diets and also the ATTD of P.
[Mh] Termos MeSH primário: 6-Fitase/farmacologia
Cálcio na Dieta/metabolismo
Fósforo na Dieta/metabolismo
Suínos/fisiologia
Óxido de Zinco/farmacologia
[Mh] Termos MeSH secundário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Dieta/veterinária
Digestão/efeitos dos fármacos
Fezes
Trato Gastrointestinal/efeitos dos fármacos
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Calcium, Dietary); 0 (Phosphorus, Dietary); EC 3.1.3.26 (6-Phytase); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.1149


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[PMID]:28380580
[Au] Autor:Kim JW; Ndou SP; Mejicanos GA; Nyachoti CM
[Ti] Título:Standardized total tract digestibility of phosphorus in flaxseed meal fed to growing and finishing pigs without or with phytase supplementation.
[So] Source:J Anim Sci;95(2):799-805, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two experiments were conducted to determine the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of P in flaxseed meal (FM) and the effect of dietary microbial phytase on the digestibility of P in FM fed to growing and finishing pigs. In Exp. 1, eighteen growing barrows (26.6 ± 1.8 kg BW) were allotted to 1 of 3 experimental diets consisting of a diet containing 32% FM that was fed with or without phytase at 500 phytase units (FTU/kg and a P-free diet in a completely randomized design to give 6 replicates per diet. The experimental period lasted 12 d including first 7 d for adaptation and 5 d for total collection of feces. Pigs were fed their assigned diets at 4% of BW at the beginning of the experiment. The daily feed allowance was offered in 2 equal portions at 0800 and 1600 h. All experimental diets were provided in mash form. Results indicated that pigs fed the diets containing FM with dietary phytase had less ( < 0.05) fecal P concentration and daily P output than those fed the diets without phytase supplementation. Also, phytase supplementation increased ( < 0.05) the ATTD of P of the diets containing FM from 37.3% to 51.8% and STTD of P of the diets containing FM from 43.2% to 57.7%. The basal endogenous P losses (EPL) was calculated at 140 ± 11 mg/kg of DMI in growing pigs fed the P-free diet. In Exp. 2, eighteen finishing pigs (78.7 ± 2.4 kg BW) were randomly allotted to 1 of 3 dietary treatments. The experimental diets and procedures were similar to those described in Exp. 1. Similar to Exp. 1, pigs fed FM diets with phytase supplementation had less ( < 0.05) P concentration in feces than those fed diets without phytase supplementation. Also, daily P output was reduced ( = 0.08) when pigs were fed the FM diets with phytase compared to those fed the FM diets without phytase. The ATTD of P in FM diets was increased ( < 0.01) from 31.4% to 45.8%, whereas the STTD of P in FM diets was increased ( < 0.01) from 37.8% to 52.3% as a result of phytase supplementation. The basal EPL was calculated at 164 ± 19 mg/kg of DMI in finishing pigs fed the P-free diet. In conclusion, the ATTD and STTD of P in FM fed to growing pigs were 37.3% and 43.2%, respectively, whereas respective values for finishing pigs were 31.4%, and 37.8%, respectively. Also, dietary phytase supplementation improved both ATTD and STTD of P in FM for both stages of pigs by an average of 33%.
[Mh] Termos MeSH primário: 6-Fitase/farmacologia
Dieta/veterinária
Linho/química
Fósforo na Dieta/administração & dosagem
Suínos/fisiologia
[Mh] Termos MeSH secundário: 6-Fitase/administração & dosagem
Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Suplementos Nutricionais
Digestão/efeitos dos fármacos
Fezes
Trato Gastrointestinal/efeitos dos fármacos
Fósforo na Dieta/metabolismo
Fósforo na Dieta/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Phosphorus, Dietary); EC 3.1.3.26 (6-Phytase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.1045


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[PMID]:28318577
[Au] Autor:Haese E; Möhring J; Steingass H; Schollenberger M; Rodehutscord M
[Ad] Endereço:Institut für Nutztierwissenschaften, Universität Hohenheim, 70599 Stuttgart, Germany.
[Ti] Título:Effect of dietary mineral phosphorus and phytate on in situ ruminal phytate disappearance from different concentrates in dairy cows.
[So] Source:J Dairy Sci;100(5):3672-3684, 2017 May.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first objective of this study was to determine the influence of dietary composition on the in situ disappearance of phytate (InsP ) from wheat, corn, soybean meal, and rapeseed meal [solvent-extracted, without (RSM) or with (hRSM) heat treatment] in the rumen of dairy cows. The second objective was to assess the primary degradation products of InsP in the rumen. Three diets differing in phosphorus and InsP concentration (basal diet = 0.38% P in dry matter; high-P diet = 0.56% P; high-InsP diet = 0.39% P) were fed to 3 ruminally fistulated lactating Jersey cows in a 3 × 3 Latin square. Ground concentrates (sieve size = 2 mm) were incubated in polyester bags in the rumen for 2, 4, 8, 16, and 24 h. The bag residues were analyzed for P, InsP , isomers of lower inositol phosphates (InsP , InsP , InsP ), and crude protein. The InsP disappeared more rapidly from cereal grains than from oilseed meals; however, after 24 h of incubation ≥95% InsP had disappeared from all concentrates except hRSM (57%; diet average). Feeding the high-InsP diet increased InsP disappearance for oilseed meals, but not for corn and wheat. The predominant InsP isomer in all bag residues was Ins(1,2,4,5,6)P followed by Ins(1,2,3,4,5)P and Ins(1,2,3,4,6)P . A further InsP isomer [Ins(1,3,4,5,6)P ] was detected in both rapeseed meal bag residues. Feeding the high-InsP diet led to lower concentrations of Ins(1,2,4,5,6)P and Ins(1,2,3,4,5)P , whereas an interaction between diet, concentrate, and time occurred for Ins(1,2,3,4,6)P and Ins(1,3,4,5,6)P . The results confirm the high potential of rumen microorganisms to hydrolyze InsP ; however, increasing the amount of InsP in the diet can further enhance InsP hydrolysis, which may be relevant when concentrates with slowly degradable InsP such as RSM or heat-treated concentrates, are fed to dairy cows. Based on the concentrations of InsP isomers, 3 and 6 phytases appear to play a major role in the rumen. Conversely, intrinsic plant phytase activity appears to be less relevant as the percentage of its primary hydrolysis product, Ins(1,2,3,4,5)P , changed only slightly upon using wheat known for high intrinsic phytase activity instead of the other concentrates. Additional information regarding the factors influencing the extent of ruminal InsP disappearance will require further studies to determine the phytase activity of rumen microorganisms and the characteristics of their respective phytases.
[Mh] Termos MeSH primário: Fósforo na Dieta/metabolismo
Ácido Fítico
[Mh] Termos MeSH secundário: Ração Animal
Animais
Bovinos
Dieta/veterinária
Feminino
Lactação
Minerais
Fósforo
Rúmen/metabolismo
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 0 (Phosphorus, Dietary); 27YLU75U4W (Phosphorus); 7IGF0S7R8I (Phytic Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28277077
[Au] Autor:Pokharel BB; Regassa A; Nyachoti CM; Kim WK
[Ad] Endereço:a Department of Animal Science , University of Manitoba , Winnipeg , Manitoba , Canada.
[Ti] Título:Effect of low levels of dietary available phosphorus on phosphorus utilization, bone mineralization, phosphorus transporter mRNA expression and performance in growing pigs.
[So] Source:J Environ Sci Health B;52(6):395-401, 2017 Jun 03.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A study was conducted to examine the effects of different dietary levels of available phosphorus (aP) on P excretion, bone mineralization, performance and the mRNA expression of sodium-dependent P transporters in growing pigs. Sixty-day old growing pigs (n = 54) with an average initial BW of 19.50 ± 1.11 kg were randomly allocated to a control diet (C) containing 0.23% available phosphorus (aP), T1 containing 0.17% aP and T2 containing 0.11% aP. There were 6 pens per treatment with 3 pigs per pen. Body weight and feed intake were measured weekly. At the end of each week, one pig from each pen was housed in a metabolic crate for 24 h to collect fecal and urine samples and then sacrificed to obtain third metacarpal (MC3) bones and jejunal and kidney samples. Bones were scanned by Dual Energy X-ray Absorptiometry (DEXA). Fecal and urine samples were sub-sampled and analyzed for P content. The expression of P transporter mRNA in jejunum and kidney samples was measured using quantitative real-time polymerase chain reaction (qRT-PCR). Data were analyzed using GLM procedure of the Statistical Analysis System (SAS Institute version 9.2). Pigs fed the T2 diet had reduced (P < 0.05) average daily gain (ADG) and gain to feed (G:F) compared to those fed the C diet during week 2. Overall, ADG and G:F were also reduced (P < 0.05) in pigs fed the T2 diet compared to those fed the C and T1 diets. Bone mineral density (BMD) and bone mineral content (BMC) were reduced (P < 0.05) in pigs fed the T2 diet compared to those fed the C diet throughout the experiment. At week 1, jejunal mRNA expression of Na (+)-dependent phosphate transporter 2 (SLC34A2) was increased (P < 0.01) in pigs fed the T2 diet compared to C diet. Renal mRNA expression of Na(+)-dependent phosphate transporter 1 (SLC34A1) and SLC34A3 were increased (P < 0.05) in pigs fed the T2 diet compared to those fed the C diet at week 2 and was accompanied by lower (P < 0.05) urinary P in pigs fed the T2 diet during week 2 and week 3. In conclusion, growing pigs are highly sensitive to low dietary P as shown by reduced ADG, bone mineralization and urinary P level, but moderate reduction in dietary P up to 0.17% aP in the diet has the potential to reduce environmental pollution by reducing P concentration in swine manure and without compromising performance.
[Mh] Termos MeSH primário: Calcificação Fisiológica/efeitos dos fármacos
Fósforo na Dieta/farmacologia
Fósforo/farmacocinética
Proteínas Cotransportadoras de Sódio-Fosfato Tipo IIa/genética
Sus scrofa/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Animais
Densidade Óssea
Fezes
Absorção Intestinal/efeitos dos fármacos
Rim/efeitos dos fármacos
Rim/metabolismo
Fósforo/metabolismo
Fósforo/urina
Fósforo na Dieta/farmacocinética
RNA Mensageiro
Reação em Cadeia da Polimerase em Tempo Real
Sus scrofa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphorus, Dietary); 0 (RNA, Messenger); 0 (Sodium-Phosphate Cotransporter Proteins, Type IIa); 27YLU75U4W (Phosphorus)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2017.1292096



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