Base de dados : MEDLINE
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  1 / 2148 MEDLINE  
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[PMID]:29311454
[Au] Autor:Saito K
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Chiba University.
[Ti] Título:[Development of Plant Metabolomics and Medicinal Plant Genomics].
[So] Source:Yakugaku Zasshi;138(1):1-18, 2018.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A variety of chemicals produced by plants, often referred to as 'phytochemicals', have been used as medicines, food, fuels and industrial raw materials. Recent advances in the study of genomics and metabolomics in plant science have accelerated our understanding of the mechanisms, regulation and evolution of the biosynthesis of specialized plant products. We can now address such questions as how the metabolomic diversity of plants is originated at the levels of genome, and how we should apply this knowledge to drug discovery, industry and agriculture. Our research group has focused on metabolomics-based functional genomics over the last 15 years and we have developed a new research area called 'Phytochemical Genomics'. In this review, the development of a research platform for plant metabolomics is discussed first, to provide a better understanding of the chemical diversity of plants. Then, representative applications of metabolomics to functional genomics in a model plant, Arabidopsis thaliana, are described. The extension of integrated multi-omics analyses to non-model specialized plants, e.g., medicinal plants, is presented, including the identification of novel genes, metabolites and networks for the biosynthesis of flavonoids, alkaloids, sulfur-containing metabolites and terpenoids. Further, functional genomics studies on a variety of medicinal plants is presented. I also discuss future trends in pharmacognosy and related sciences.
[Mh] Termos MeSH primário: Genômica/tendências
Metabolômica/tendências
Plantas Medicinais/genética
Plantas Medicinais/metabolismo
Plantas/genética
Plantas/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/biossíntese
Arabidopsis/genética
Arabidopsis/metabolismo
Flavonoides/biossíntese
Farmacognosia/tendências
Compostos Fitoquímicos/biossíntese
Compostos de Enxofre/metabolismo
Terpenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Flavonoids); 0 (Phytochemicals); 0 (Sulfur Compounds); 0 (Terpenes)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00193


  2 / 2148 MEDLINE  
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[PMID]:28471462
[Au] Autor:Block E; Batista VS; Matsunami H; Zhuang H; Ahmed L
[Ad] Endereço:Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222, USA. eblock@albany.edu.
[Ti] Título:The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.
[So] Source:Nat Prod Rep;34(5):529-557, 2017 05 10.
[Is] ISSN:1460-4752
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Covering: up to the end of 2017While suggestions concerning the possible role of metals in olfaction and taste date back 50 years, only recently has it been possible to confirm these proposals with experiments involving individual olfactory receptors (ORs). A detailed discussion of recent experimental results demonstrating the key role of metals in enhancing the response of human and other vertebrate ORs to specific odorants is presented against the backdrop of our knowledge of how the sense of smell functions both at the molecular and whole animal levels. This review emphasizes the role of metals in the detection of low molecular weight thiols, sulfides, and other organosulfur compounds, including those found in strong-smelling animal excretions and plant volatiles, and those used in gas odorization. Alternative theories of olfaction are described, with evidence favoring the modified "shape" theory. The use of quantum mechanical/molecular modeling (QM/MM), site-directed mutagenesis and saturation-transfer-difference (STD) NMR is discussed, providing support for biological studies of mouse and human receptors, MOR244-3 and OR OR2T11, respectively. Copper is bound at the active site of MOR244-3 by cysteine and histidine, while cysteine, histidine and methionine are involved with OR2T11. The binding pockets of these two receptors are found in different locations in the three-dimensional seven transmembrane models. Another recently deorphaned human olfactory receptor, OR2M3, highly selective for a thiol from onions, and a broadly-tuned thiol receptor, OR1A1, are also discussed. Other topics covered include the effects of nanoparticles and heavy metal toxicants on vertebrate and fish ORs, intranasal zinc products and the loss of smell (anosmia).
[Mh] Termos MeSH primário: Receptores Odorantes
Compostos de Enxofre/química
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Modelos Moleculares
Estrutura Molecular
Peso Molecular
Odorantes
Neurônios Receptores Olfatórios/fisiologia
Vertebrados
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Odorant); 0 (Sulfur Compounds)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1039/c7np00016b


  3 / 2148 MEDLINE  
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[PMID]:28782186
[Au] Autor:Sowaileh MF; Hazlitt RA; Colby DA
[Ad] Endereço:Department of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
[Ti] Título:Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement.
[So] Source:ChemMedChem;12(18):1481-1490, 2017 Sep 21.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The success of fluorinated molecules in drug design has led medicinal chemists to search for new fluorine-containing substituents. A major recently developed group is the pentafluorosulfanyl group. This group is stable under physiological conditions and displays unique physical and chemical properties. There are currently few synthetic methods to install the SF group, yet efforts to integrate this group into lead optimization continue unabated. Typically, the SF group has been used as a replacement for trifluoromethyl, tert-butyl, halogen, or nitro groups. In this review, the use of the SF group as a bioisosteric replacement for each of these three functionalities is compared and contrasted across various groups of biologically active molecules. The organization and presentation of these data should be instructive to medicinal chemists considering to design synthetic strategies to access SF -substituted molecules.
[Mh] Termos MeSH primário: Sulfetos/química
Compostos de Enxofre/química
[Mh] Termos MeSH secundário: Antiprotozoários/química
Antiprotozoários/farmacologia
Desenho de Drogas
Ácido Flufenâmico/análogos & derivados
Ácido Flufenâmico/farmacologia
Halogenação
NADH NADPH Oxirredutases/antagonistas & inibidores
NADH NADPH Oxirredutases/metabolismo
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/antagonistas & inibidores
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/metabolismo
Plasmodium falciparum/efeitos dos fármacos
Plasmodium falciparum/enzimologia
Ligação Proteica
Receptores de Canabinoides/química
Receptores de Canabinoides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Receptors, Cannabinoid); 0 (Sulfides); 0 (Sulfur Compounds); 60GCX7Y6BH (Flufenamic Acid); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.5.2 (dihydroorotate dehydrogenase); EC 1.6.- (NADH, NADPH Oxidoreductases); EC 1.8.1.12 (trypanothione reductase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201700356


  4 / 2148 MEDLINE  
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[PMID]:28763951
[Au] Autor:Roullier-Gall C; Hemmler D; Gonsior M; Li Y; Nikolantonaki M; Aron A; Coelho C; Gougeon RD; Schmitt-Kopplin P
[Ad] Endereço:Analytical Food Chemistry, Technische Universität München, Alte Akademie 10, 85354 Freising-Weihenstephan, Germany; Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
[Ti] Título:Sulfites and the wine metabolome.
[So] Source:Food Chem;237:106-113, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In a context of societal concern about food preservation, the reduction of sulfite input plays a major role in the wine industry. To improve the understanding of the chemistry involved in the SO protection, a series of bottle aged Chardonnay wines made from the same must, but with different concentrations of SO added at pressing were analyzed by ultrahigh resolution mass spectrometry (FT-ICR-MS) and excitation emission matrix fluorescence (EEMF). Metabolic fingerprints from FT-ICR-MS data could discriminate wines according to the added concentration to the must but they also revealed chemistry-related differences according to the type of stopper, providing a wine metabolomics picture of the impact of distinct stopping strategies. Spearman rank correlation was applied to link the statistically modeled EEMF components (parallel factor analysis (PARAFAC)) and the exact mass information from FT-ICR-MS, and thus revealing the extent of sulfur-containing compounds which could show some correlation with fluorescence fingerprints.
[Mh] Termos MeSH primário: Vinho
[Mh] Termos MeSH secundário: Espectrometria de Massas
Metaboloma
Sulfitos
Compostos de Enxofre
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfites); 0 (Sulfur Compounds)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  5 / 2148 MEDLINE  
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[PMID]:28648258
[Au] Autor:Djokic MR; Ristic ND; Olahova N; Marin GB; Van Geem KM
[Ad] Endereço:Laboratory for Chemical Technology, Ghent University, Technologiepark 914, 9052 Ghent, Belgium. Electronic address: Marko.Djokic@UGent.be.
[Ti] Título:Quantitative on-line analysis of sulfur compounds in complex hydrocarbon matrices.
[So] Source:J Chromatogr A;1509:102-113, 2017 Aug 04.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An improved method for on-line measurement of sulfur containing compounds in complex matrices is presented. The on-line system consists of a specifically designed sampling system connected to a comprehensive two-dimensional gas chromatograph (GC×GC) equipped with two capillary columns (Rtx -1 PONA×SGE BPX50), a flame ionization detector (FID) and a sulfur chemiluminescence detector (SCD). The result is an unprecedented sensitivity down to ppm level (1 ppm-w) for various sulfur containing compounds in very complex hydrocarbon matrices. In addition to the GC×GC-SCD, the low molecular weight sulfur containing compounds such as hydrogen sulfide (H S) and carbonyl sulfide (COS) can be analyzed using a thermal conductivity detector of a so-called refinery gas analyzer (RGA). The methodology was extensively tested on a continuous flow pilot plant for steam cracking, in which quantification of sulfur containing compounds in the reactor effluent was carried out using 3-chlorothiophene as internal standard. The GC×GC-FID/-SCD settings were optimized for ppm analysis of sulfur compounds in olefin-rich (ethylene- and propylene-rich) hydrocarbon matrices produced by steam cracking of petroleum feedstocks. Besides that is primarily used for analysis of the hydrocarbon matrix, FID of the GC×GC-FID/-SCD set-up serves to double check the amount of added sulfur internal standard which is crucial for a proper quantification of sulfur compounds. When vacuum gas oil containing 780 ppm-w of elemental sulfur in the form of benzothiophenes and dibenzothiophenes is subjected to steam cracking, the sulfur balance was closed, with 75% of the sulfur contained in the feed is converted to hydrogen sulfide, 13% to alkyl homologues of thiophene while the remaining 12% is present in the form of alkyl homologues of benzothiophenes. The methodology can be applied for many other conversion processes which use sulfur containing feeds such as hydrocracking, catalytic cracking, kerogen evolution, bio-waste pyrolysis, supercritical water treatment, etc.
[Mh] Termos MeSH primário: Automação/métodos
Cromatografia Gasosa/métodos
Ionização de Chama/métodos
Hidrocarbonetos/química
Compostos de Enxofre/química
[Mh] Termos MeSH secundário: Catálise
Petróleo/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons); 0 (Petroleum); 0 (Sulfur Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  6 / 2148 MEDLINE  
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[PMID]:28647146
[Au] Autor:Potgieter H; Bekker R; Beigley J; Rohwer E
[Ad] Endereço:Operations and Analytics Department, Group Technology R&T, Sasolburg, 1947, South Africa. Electronic address: johann.potgieter@sasol.com.
[Ti] Título:Analysis of oxidised heavy paraffininc products by high temperature comprehensive two-dimensional gas chromatography.
[So] Source:J Chromatogr A;1509:123-131, 2017 Aug 04.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Heavy petroleum fractions are produced during crude and synthetic crude oil refining processes and they need to be upgraded to useable products to increase their market value. Usually these fractions are upgraded to fuel products by hydrocracking, hydroisomerization and hydrogenation processes. These fractions are also upgraded to other high value commercial products like lubricant oils and waxes by distillation, hydrogenation, and oxidation and/or blending. Oxidation of hydrogenated heavy paraffinic fractions produces high value products that contain a variety of oxygenates and the characterization of these heavy oxygenates is very important for the control of oxidation processes. Traditionally titrimetric procedures are used to monitor oxygenate formation, however, these titrimetric procedures are tedious and lack selectivity toward specific oxygenate classes in complex matrices. Comprehensive two-dimensional gas chromatography (GC×GC) is a way of increasing peak capacity for the comprehensive analysis of complex samples. Other groups have used HT-GC×GC to extend the carbon number range attainable by GC×GC and have optimised HT-GC×GC parameters for the separation of aromatics, nitrogen-containing compounds as well as sulphur-containing compounds in heavy petroleum fractions. HT-GC×GC column combinations for the separation of oxygenates in oxidised heavy paraffinic fractions are optimised in this study. The advantages of the HT-GC×GC method in the monitoring of the oxidation reactions of heavy paraffinic fraction samples are illustrated.
[Mh] Termos MeSH primário: Cromatografia Gasosa/métodos
Parafina/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa/instrumentação
Temperatura Alta
Hidrogenação
Compostos de Nitrogênio/química
Oxirredução
Petróleo/análise
Compostos de Enxofre/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Compounds); 0 (Petroleum); 0 (Sulfur Compounds); 8002-74-2 (Paraffin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


  7 / 2148 MEDLINE  
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[PMID]:28475682
[Au] Autor:de Little SC; Umina PA
[Ad] Endereço:Cesar, 293 Royal Parade, Parkville, Victoria 3052, Australia.
[Ti] Título:Susceptibility of Australian Myzus persicae (Hemiptera: Aphididae) to Three Recently Registered Insecticides: Spirotetramat, Cyantraniliprole, and Sulfoxaflor.
[So] Source:J Econ Entomol;110(4):1764-1769, 2017 Aug 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The green peach aphid, Myzus persicae (Sulzer), is a significant agricultural pest that has developed resistance to a large number of insecticides globally. Within Australia, resistance has previously been confirmed for multiple chemical groups, including pyrethroids, carbamates, organophosphates, and neonicotinoids. In this study, we use leaf-dip and topical bioassays to investigate susceptibility and potential cross-resistance of 12 field-collected populations of Australian M. persicae to three recently registered insecticides: sulfoxaflor, spirotetramat, and cyantraniliprole. Despite all 12 populations carrying known resistance mechanisms to carbamates, organophosphates, and pyrethroids, and two populations also exhibiting low-level metabolic resistance to neonicotinoids, we found little evidence of variation in susceptibility to sulfoxafor, spirotetramat, or cyantraniliprole. This provides further evidence that cross-resistance to spirotetramat, cyantraniliprole, and sulfoxaflor in M. persicae is not conferred by the commonly occurring resistance mechanisms MACE, super-kdr, amplification of the E4 esterase gene, or enhanced expression and copy number of the P450 gene, CYP6CY3. Importantly, this study also established toxicity baseline data that will be important for future monitoring of insecticide responses of M. persicae from both broadacre and horticultural crops.
[Mh] Termos MeSH primário: Afídeos/efeitos dos fármacos
Compostos Aza/farmacologia
Resistência a Inseticidas
Inseticidas/farmacologia
Pirazóis/farmacologia
Piridinas/farmacologia
Compostos de Espiro/farmacologia
Compostos de Enxofre/farmacologia
ortoaminobenzoatos/farmacologia
[Mh] Termos MeSH secundário: Animais
Afídeos/genética
Afídeos/crescimento & desenvolvimento
Afídeos/fisiologia
Austrália
Proteínas de Insetos/genética
Ninfa/efeitos dos fármacos
Ninfa/genética
Ninfa/crescimento & desenvolvimento
Ninfa/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aza Compounds); 0 (Insect Proteins); 0 (Insecticides); 0 (Pyrazoles); 0 (Pyridines); 0 (Spiro Compounds); 0 (Sulfur Compounds); 0 (ortho-Aminobenzoates); 4G7KR034OX (spirotetramat); 671W88OY8K (sulfoxaflor); LO6K6H48FD (cyantraniliprole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox132


  8 / 2148 MEDLINE  
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[PMID]:28436828
[Au] Autor:Varela C; Barker A; Tran T; Borneman A; Curtin C
[Ad] Endereço:The Australian Wine Research Institute, PO Box 197, Glen Osmond, Adelaide, South Australia 5064, Australia. Electronic address: Cristian.Varela@awri.com.au.
[Ti] Título:Sensory profile and volatile aroma composition of reduced alcohol Merlot wines fermented with Metschnikowia pulcherrima and Saccharomyces uvarum.
[So] Source:Int J Food Microbiol;252:1-9, 2017 Jul 03.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Strategies for production of wines containing lower alcohol concentrations are in strong demand, for reasons of quality, health, and taxation. Development and application of wine yeasts that are less efficient at transforming grape sugars into ethanol has the potential to allow winemakers the freedom to make lower alcohol wines from grapes harvested at optimal ripeness, without the need for post-fermentation processes aimed at removing ethanol. We have recently shown that two non-conventional wine yeast species Metschnikowia pulcherrima and Saccharomyces uvarum were both able to produce wine with reduced alcohol concentration. Both species produced laboratory-scale wines with markedly different volatile aroma compound composition relative to Saccharomyces cerevisiae. This work describes the volatile composition and sensory profiles of reduced-alcohol pilot-scale Merlot wines produced with M. pulcherrima and S. uvarum. Wines fermented with M. pulcherrima contained 1.0% v/v less ethanol than S. cerevisiae fermented wines, while those fermented with S. uvarum showed a 1.7% v/v reduction in ethanol. Compared to S. cerevisiae ferments, wines produced with M. pulcherrima showed higher concentrations of ethyl acetate, total esters, total higher alcohols and total sulfur compounds, while wines fermented with S. uvarum were characterised by the highest total concentration of higher alcohols. Sensorially, M. pulcherrima wines received relatively high scores for sensory descriptors such as red fruit and fruit flavour and overall exhibited a sensory profile similar to that of wine made with S. cerevisiae, whereas the main sensory descriptors associated with wines fermented with S. uvarum were barnyard and meat. This work demonstrates the successful application of M. pulcherrima AWRI3050 for the production of pilot-scale red wines with reduced alcohol concentration and highlights the need for rigorous evaluation of non-conventional yeasts with regard to their sensory impacts.
[Mh] Termos MeSH primário: Reatores Biológicos/microbiologia
Etanol/análise
Metschnikowia/metabolismo
Saccharomyces/metabolismo
Vinho/análise
[Mh] Termos MeSH secundário: Acetatos/análise
Ésteres/análise
Etanol/metabolismo
Fermentação
Aromatizantes/análise
Frutas/química
Metschnikowia/crescimento & desenvolvimento
Saccharomyces/crescimento & desenvolvimento
Compostos de Enxofre/análise
Vitis/metabolismo
Vitis/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Esters); 0 (Flavoring Agents); 0 (Sulfur Compounds); 3K9958V90M (Ethanol); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  9 / 2148 MEDLINE  
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[PMID]:28402302
[Au] Autor:Fisher RM; Barczak RJ; Alvarez Gaitan JP; Le-Minh N; Stuetz RM
[Ad] Endereço:School of Civil and Environmental Engineering, UNSW, Sydney, Australia E-mail: ruth.fisher@student.unsw.edu.au.
[Ti] Título:Odorous volatile organic compound (VOC) emissions from ageing anaerobically stabilised biosolids.
[So] Source:Water Sci Technol;75(7-8):1617-1624, 2017 Apr.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Opportunities for the beneficial re-use of biosolids are limited by nuisance odour emissions. Volatile organic compounds (VOCs) from anaerobically stabilised biosolids were measured to identify compounds that could contribute to the overall odour character of nuisance emissions. Flux hood sampling and chemical analysis were used to identify VOCs emitted from biosolids as they were stored in ambient conditions. Compounds emitted varied as the biosolid cakes were stored for a period of 50 days. VOCs detected in the biosolids are likely to occur from catchment sources as well as abiotic and biotic generation in the wastewater processing and the biosolids as they are stored. Odour activity values (OAVs) were used to compare odorants. Trimethylamine was the only VOC detected that exceeded the sulfur compounds in terms of OAVs. Other compounds such as limonene, ethyl methyl benzene and acetic acid were detected at concentrations exceeding their olfactory detection limits, however at lower OAVs than sulfur compounds.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Odorantes/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/análise
Poluentes Atmosféricos/metabolismo
Anaerobiose
Biodegradação Ambiental
Compostos de Enxofre/análise
Compostos de Enxofre/metabolismo
Compostos Orgânicos Voláteis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Sulfur Compounds); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2017.030


  10 / 2148 MEDLINE  
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[PMID]:28319129
[Au] Autor:Nani BD; Lima PO; Marcondes FK; Groppo FC; Rolim GS; Moraes AB; Cogo-Müller K; Franz-Montan M
[Ad] Endereço:Department of Physiological Sciences, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
[Ti] Título:Changes in salivary microbiota increase volatile sulfur compounds production in healthy male subjects with academic-related chronic stress.
[So] Source:PLoS One;12(3):e0173686, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the associations among salivary bacteria, oral emanations of volatile sulfur compounds, and academic-related chronic stress in healthy male subjects. MATERIALS AND METHODS: Seventy-eight healthy male undergraduate dental students were classified as stressed or not by evaluation of burnout, a syndrome attributed to academic-related chronic stress. This evaluation was carried out using the Maslach Burnout Inventory-Student Survey questionnaire. Oral emanations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were measured using an Oral Chroma™ portable gas chromatograph. The amounts in saliva of total bacteria and seven bacteria associated with halitosis were quantified by qPCR. The in vitro production of H2S by S. moorei and/or F. nucleatum was also measured with the Oral Chroma™ instrument. RESULTS: The stressed students group showed increased oral emanations of hydrogen sulfide and dimethyl sulfide, together with higher salivary Solobacterium moorei levels (p < 0.05, Mann Whitney test). There were moderate positive correlations between the following pairs of variables: Fusobacterium nucleatum and S. moorei; F. nucleatum and hydrogen sulfide; Tannerella forsythia and F. nucleatum; T. forsythia and S. moorei. These correlations only occurred for the stressed group (p < 0.05, Spearman correlation). The in vitro experiment demonstrated that S. moorei increased H2S production by F. nucleatum (p < 0.05, ANOVA and Tukey's test). CONCLUSION: The increased amount of S. moorei in saliva, and its coexistence with F. nucleatum and T. forsythia, seemed to be responsible for increased oral hydrogen sulfide in the healthy male stressed subjects.
[Mh] Termos MeSH primário: Voluntários Saudáveis
Saliva/microbiologia
Estresse Psicológico/microbiologia
Estudantes/psicologia
Compostos de Enxofre/química
Compostos de Enxofre/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Bactérias/metabolismo
Halitose/microbiologia
Seres Humanos
Masculino
Volatilização
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfur Compounds)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173686



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