Base de dados : MEDLINE
Pesquisa : D01.975 [Categoria DeCS]
Referências encontradas : 4012 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 402 ir para página                         

  1 / 4012 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29300478
[Au] Autor:Li R; Sun H; Wang S; Wang Y; Yu K
[Ad] Endereço:School of Marine Sciences, Guangxi University , Nanning 530004, P. R. China.
[Ti] Título:Retention of CdS/ZnS Quantum Dots (QDs) on the Root Epidermis of Woody Plant and Its Implications by Benzo[a]pyrene: Evidence from the in Situ Synchronous Nanosecond Time-Resolved Fluorescence Spectra Method.
[So] Source:J Agric Food Chem;66(4):814-821, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The retention of CdS/ZnS QDs on the epidermis has been confirmed to be one of the core procedures during the root uptake process. However, the retention mechanisms of QDs on the epidermis of woody plant were poorly understood for lacking of an appropriate QD quantitative method. In this study, a novel method for in situ determination of CdS/ZnS QDs retained on the root epidermis was established using synchronous nanosecond time-resolved fluorescence spectroscopy. No correlations between K values of oleylamine-CdS/ZnS QDs retained on the epidermal tissues and the surface/bulk composition of mangrove root were observed (p > 0.05) due to the existence of endocytosis mechanisms during the QD uptake processes. Moreover, the difference of the CdS/ZnS QDs in water and further translocated to xylem/phloem of root rather than the combination with cell wall/membranes was the predominant reason that caused the K values to follow the sequence of PEG-COOH-CdS/ZnS QDs < PEG-NH -CdS/ZnS QDs ≪ oleylamine-CdS/ZnS QDs.
[Mh] Termos MeSH primário: Benzo(a)pireno
Compostos de Cádmio/análise
Raízes de Plantas/química
Pontos Quânticos/análise
Espectrometria de Fluorescência/métodos
Sulfetos/análise
Compostos de Zinco/análise
[Mh] Termos MeSH secundário: Avicennia
Compostos de Cádmio/metabolismo
Endocitose
Epiderme/química
Epiderme/metabolismo
Floema/metabolismo
Raízes de Plantas/metabolismo
Pontos Quânticos/metabolismo
Rhizophoraceae
Sulfetos/metabolismo
Água/química
Xilema/metabolismo
Compostos de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cadmium Compounds); 0 (Sulfides); 0 (Zinc Compounds); 057EZR4Z7Q (cadmium sulfide); 059QF0KO0R (Water); 3417WMA06D (Benzo(a)pyrene); KPS085631O (zinc sulfide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04258


  2 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28987498
[Au] Autor:Bahrani S; Ghaedi M; Dashtian K; Ostovan A; Mansoorkhani MJK; Salehi A
[Ad] Endereço:Departmentof chemistry, Yasouj University, Yasouj, 75918-74831, Iran.
[Ti] Título:MOF-5(Zn)-Fe O nanocomposite based magnetic solid-phase microextraction followed by HPLC-UV for efficient enrichment of colchicine in root of colchicium extracts and plasma samples.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1067:45-52, 2017 Nov 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In present work, facile method is developed for determination of colchicine in human plasma sample, autumn and spring root of colchicium extracts by ultrasound assisted dispersive magnetic solid phase microextraction followed by HPLC-UV method (UAD-MSPME-HPLC-UV). Magnetic (Fe O -nanoparticles) metal organic framework-5, (MOF-5(Zn)-Fe O NPs) was synthesized by dispersing MOF-5 and Fe(NO ) .9H O in ethylene glycol (as capping agent) and NaOH (pH adjustment agent) by hydrothermal method. The prepared sorbent was characterized via XRD and SEM analysis and applied as magnetic solid phase in UAD-MSPME-HPLC-UV method. In this method, colchicine molecules were sorbed on MOF-5(Zn)-Fe O NPs sorbent by various mechanisms like ion exchange, hydrogen bonding and electrostatic, á´¨-á´¨, hard-hard and dipole-ion interaction followed by exposing sonication waves as incremental mass transfer agent and then the sorbent was separated from the sample matrix by an external magnetic fields. Subsequently, accumulated colchicine were eluted by small volume of desorption organic solvent. Influence of operational variables such as MOF-5(Zn)-Fe O NPs mass, volume of extracting solvent and sonication time on response property (recovery) were studied and optimized by central composite design (CCD) combined with desirability function (DF) approach. Under optimum condition, the method has wide linear calibration rang (0.5-1700ngmL ) with reasonable detection limit (0.13ngmL ) and R =0.9971. Finally, the UAD-MSPME-HPLC-UV method was successfully applied for determination of colchicine autumn and spring root of colchicium extracts and plasma samples.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Colchicina
Colchicum/química
Nanocompostos/química
Extratos Vegetais/química
Microextração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Colchicina/análise
Colchicina/química
Colchicina/isolamento & purificação
Óxido Ferroso-Férrico/química
Concentração de Íons de Hidrogênio
Limite de Detecção
Modelos Lineares
Raízes de Plantas/química
Reprodutibilidade dos Testes
Compostos de Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Zinc Compounds); SML2Y3J35T (Colchicine); XM0M87F357 (Ferrosoferric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  3 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28953660
[Au] Autor:Xie F; Zhang X; Xie L
[Ad] Endereço:Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
[Ti] Título:Prognostic value of serum zinc levels in patients with acute HC/zinc chloride smoke inhalation.
[So] Source:Medicine (Baltimore);96(39):e8156, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hexachloroethane (HC)/zinc chloride (ZnCl, smoke bomb) exposure in the military setting results in lung injury which is uncommon and has been rarely described in previous studies. The aim of this study is to investigate the correlation between the serum zinc in patients with HC/ZnCl smoke inhalation lung injury and disease severity. A total of 15 patients with HC/ZnCl-related conditions were recruited in this study. The serum zinc level and the pulmonary function tests and liver function tests including total lung capacity (TLC), forced vital capacity (FVC), forced expiratory pressure in 1 second (FEV1), alanine aminotransferase (ALT), and aspartate transaminase (AST) were analyzed. Eleven cases had mild clinical manifestations. Four cases rapidly developed features typical of severe adult respiratory distress syndrome. The level of serum zinc was increased, but FVC, FEV1, and TLC was decreased significantly in the moderate and severe cases. In addition, the serum zinc level correlated well with the TLC, FVC, and FEV1 (r = -0.587, -0.626, -0.617, respectively; P = .027, .017, .019, respectively). The 4 cases in moderate and severe group had delayed impairment of liver functions after the accident. This study suggested that the serum zinc level may be associated with the severity of lung and liver injuries after HC/ZnCl smoke inhalation.
[Mh] Termos MeSH primário: Bombas (Dispositivos Explosivos)
Doença Hepática Induzida por Substâncias e Drogas
Cloretos
Etano/análogos & derivados
Hidrocarbonetos Clorados
Lesão Pulmonar
Síndrome do Desconforto Respiratório do Adulto
Lesão por Inalação de Fumaça
Compostos de Zinco
Zinco/sangue
[Mh] Termos MeSH secundário: Adulto
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Doença Hepática Induzida por Substâncias e Drogas/sangue
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
Doença Hepática Induzida por Substâncias e Drogas/etiologia
China
Cloretos/química
Cloretos/toxicidade
Etano/química
Etano/toxicidade
Feminino
Seres Humanos
Hidrocarbonetos Clorados/química
Hidrocarbonetos Clorados/toxicidade
Lesão Pulmonar/sangue
Lesão Pulmonar/induzido quimicamente
Lesão Pulmonar/diagnóstico
Masculino
Militares
Valor Preditivo dos Testes
Prognóstico
Síndrome do Desconforto Respiratório do Adulto/sangue
Síndrome do Desconforto Respiratório do Adulto/diagnóstico
Síndrome do Desconforto Respiratório do Adulto/etiologia
Testes de Função Respiratória
Índice de Gravidade de Doença
Fumaça/análise
Lesão por Inalação de Fumaça/sangue
Lesão por Inalação de Fumaça/diagnóstico
Lesão por Inalação de Fumaça/etiologia
Estatística como Assunto
Compostos de Zinco/química
Compostos de Zinco/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Hydrocarbons, Chlorinated); 0 (Smoke); 0 (Zinc Compounds); 86Q357L16B (zinc chloride); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); G30K3QQT4J (hexachloroethane); J41CSQ7QDS (Zinc); L99N5N533T (Ethane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008156


  4 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28933844
[Au] Autor:Morreale FE; Testa A; Chaugule VK; Bortoluzzi A; Ciulli A; Walden H
[Ad] Endereço:MRC Protein Phosphorylation and Ubiquitylation Unit, ‡Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.
[Ti] Título:Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
[So] Source:J Med Chem;60(19):8183-8191, 2017 Oct 12.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Efforts to develop inhibitors, activators, and effectors of biological reactions using small molecule libraries are often hampered by interference compounds, artifacts, and false positives that permeate the pool of initial hits. Here, we report the discovery of a promising initial hit compound targeting the Fanconi anemia ubiquitin-conjugating enzyme Ube2T and describe its biophysical and biochemical characterization. Analysis of the co-crystal structure led to the identification of a contaminating zinc ion as solely responsible for the observed effects. Zinc binding to the active site cysteine induces a domain swap in Ube2T that leads to cyclic trimerization organized in an open-ended linear assembly. Our study serves as a cautionary tale for screening small molecule libraries and provides insights into the structural plasticity of ubiquitin-conjugating enzymes.
[Mh] Termos MeSH primário: Enzimas de Conjugação de Ubiquitina/química
Enzimas de Conjugação de Ubiquitina/efeitos dos fármacos
Compostos de Zinco/química
Compostos de Zinco/farmacologia
[Mh] Termos MeSH secundário: Domínio Catalítico
Cristalografia por Raios X
Cisteína
Ensaios de Triagem em Larga Escala
Modelos Moleculares
Dobramento de Proteína
Estrutura Secundária de Proteína/efeitos dos fármacos
Bibliotecas de Moléculas Pequenas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Small Molecule Libraries); 0 (Zinc Compounds); EC 2.3.2.23 (UBE2T protein, human); EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b01071


  5 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28882485
[Au] Autor:Zaremba A; Miller DS; Fricker G
[Ad] Endereço:Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany; Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, United States.
[Ti] Título:Zinc chloride rapidly stimulates efflux transporters in renal proximal tubules of killifish (Fundulus heteroclitus).
[So] Source:Toxicol Appl Pharmacol;334:88-99, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multidrug resistance-related protein 2 (Mrp2) is an ATP-driven efflux pump at the luminal membrane in renal proximal tubules. It acts as detoxification mechanism by transporting xenobiotics and metabolic products into urine. The trace element zinc is essential for cellular growth, differentiation and survival. It modulates immune response and is used as dietary supplement. Here, we found that 0.1-10µM ZnCl rapidly stimulated transport of the Mrp2 probe substrate Texas Red (TR) in isolated killifish renal proximal tubules, which provide an established model system to measure efflux transporter activity by using fluorescent probe substrates, confocal microscopy and image analysis. This stimulation was insensitive to the translation inhibitor cycloheximide (CHX), but it was quickly reversed by removing ZnCl from the incubation medium. ZnCl -induced transport stimulation was abolished by inhibitors and antagonists of the endothelin receptor type B (ET )/nitric oxide synthase (NOS)/protein kinase C (PKC) pathway. Moreover, ZnCl -induced effects were blocked by inhibition of PKCα using Gö6976 and PKCα inhibitor peptide C2-4. Both the phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002 and the mammalian target of rapamycin (mTOR) inhibitor rapamycin abolished ZnCl -induced transport stimulation. Furthermore, the stimulating effects of ZnCl were blocked by GSK650394, an inhibitor of the downstream target serum- and glucocorticoid-inducible kinase 1 (SGK1). ZnCl also stimulated transport mediated by P-glycoprotein (P-gp) and Breast cancer resistance protein (Bcrp). This is the first report about zinc affecting efflux transporter activity and demonstrates that ZnCl triggers a suite of signaling events to evoke a rapid stimulation of ABC transporter-mediated efflux in killifish proximal tubules.
[Mh] Termos MeSH primário: Proteínas de Transporte/metabolismo
Cloretos/toxicidade
Regulação da Expressão Gênica/efeitos dos fármacos
Túbulos Renais Proximais/efeitos dos fármacos
Compostos de Zinco/toxicidade
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte/genética
Fundulidae
Proteínas Imediatamente Precoces/genética
Proteínas Imediatamente Precoces/metabolismo
Fosfatidilinositol 3-Quinases/genética
Fosfatidilinositol 3-Quinases/metabolismo
Proteína Quinase C-alfa/genética
Proteína Quinase C-alfa/metabolismo
Proteínas Serina-Treonina Quinases/genética
Proteínas Serina-Treonina Quinases/metabolismo
Transdução de Sinais
Serina-Treonina Quinases TOR/genética
Serina-Treonina Quinases TOR/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Chlorides); 0 (Immediate-Early Proteins); 0 (Zinc Compounds); 86Q357L16B (zinc chloride); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (serum-glucocorticoid regulated kinase); EC 2.7.11.13 (Protein Kinase C-alpha)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


  6 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28814517
[Au] Autor:Kaushik N; Subramani C; Anang S; Muthumohan R; Shalimar; Nayak B; Ranjith-Kumar CT; Surjit M
[Ad] Endereço:Virology Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
[Ti] Título:Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase.
[So] Source:J Virol;91(21), 2017 Nov 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatitis E virus (HEV) causes an acute, self-limiting hepatitis in healthy individuals and leads to chronic disease in immunocompromised individuals. HEV infection in pregnant women results in a more severe outcome, with the mortality rate going up to 30%. Though the virus usually causes sporadic infection, epidemics have been reported in developing and resource-starved countries. No specific antiviral exists against HEV. A combination of interferon and ribavirin therapy has been used to control the disease with some success. Zinc is an essential micronutrient that plays crucial roles in multiple cellular processes. Zinc salts are known to be effective in reducing infections caused by few viruses. Here, we investigated the effect of zinc salts on HEV replication. In a human hepatoma cell (Huh7) culture model, zinc salts inhibited the replication of genotype 1 (g-1) and g-3 HEV replicons and g-1 HEV infectious genomic RNA in a dose-dependent manner. Analysis of a replication-defective mutant of g-1 HEV genomic RNA under similar conditions ruled out the possibility of zinc salts acting on replication-independent processes. An ORF4-Huh7 cell line-based infection model of g-1 HEV further confirmed the above observations. Zinc salts did not show any effect on the entry of g-1 HEV into the host cell. Furthermore, our data reveal that zinc salts directly inhibit the activity of viral RNA-dependent RNA polymerase (RdRp), leading to inhibition of viral replication. Taken together, these studies unravel the ability of zinc salts in inhibiting HEV replication, suggesting their possible therapeutic value in controlling HEV infection. Hepatitis E virus (HEV) is a public health concern in resource-starved countries due to frequent outbreaks. It is also emerging as a health concern in developed countries owing to its ability to cause acute and chronic infection in organ transplant and immunocompromised individuals. Although antivirals such as ribavirin have been used to treat HEV cases, there are known side effects and limitations of such therapy. Our discovery of the ability of zinc salts to block HEV replication by virtue of their ability to inhibit the activity of viral RdRp is important because these findings pave the way to test the efficacy of zinc supplementation therapy in HEV-infected patients. Since zinc supplementation therapy is known to be safe in healthy individuals and since high-dose zinc is used in the treatment of Wilson's disease, it may be possible to control HEV-associated health problems following a similar treatment regimen.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Vírus da Hepatite E/efeitos dos fármacos
Hepatite E/tratamento farmacológico
RNA Replicase/antagonistas & inibidores
Replicação Viral/efeitos dos fármacos
Compostos de Zinco/farmacologia
[Mh] Termos MeSH secundário: Carcinoma Hepatocelular/enzimologia
Carcinoma Hepatocelular/patologia
Carcinoma Hepatocelular/virologia
Hepatite E/virologia
Vírus da Hepatite E/enzimologia
Vírus da Hepatite E/genética
Seres Humanos
Neoplasias Hepáticas/enzimologia
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/virologia
RNA Viral/genética
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (RNA, Viral); 0 (Zinc Compounds); EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE


  7 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28686928
[Au] Autor:Zhao B; Xu X; Xu S; Chen X; Li H; Zeng F
[Ad] Endereço:School of Resources and Civil Engineering, Northeastern University, Shenyang 110819, China.
[Ti] Título:Surface characteristics and potential ecological risk evaluation of heavy metals in the bio-char produced by co-pyrolysis from municipal sewage sludge and hazelnut shell with zinc chloride.
[So] Source:Bioresour Technol;243:375-383, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Municipal sewage sludge (MSS) and hazelnut shell were used for co-pyrolysis by chemical activation with ZnCl . The surface characteristics and potential ecological risk evaluation of heavy metals in the bio-char produced by co-pyrolysis were analyzed by surface analyzer and BCR sequential extraction. When raw materials with ZnCl (3mol/L) were co-pyrolyzed at 500°C for 90min, specific surface area of the bio-char is 598.73m /g, and iodine absorption number is 607.85mg/g. For microcosmic surface of the bio-char, the ratio of micropore area is stabilized from 0.74 to 0.80 of the total specific surface area, and hazelnut shell is effective to generate microporous construction. For the migration and transformation behavior of heavy metals, pyrolysis promoted mobile fraction (F1 and F2) to stable fraction (F3 and F4) with increasing pyrolysis temperature. The potential ecological risk of heavy metals transforms from considerable risk to low risk after pyrolysis at 500°C.
[Mh] Termos MeSH primário: Cloretos
Corylus
Metais Pesados
Esgotos
Compostos de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Metals, Heavy); 0 (Sewage); 0 (Zinc Compounds); 86Q357L16B (zinc chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  8 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28686686
[Au] Autor:Rao K; Sethi K; Ischia J; Gibson L; Galea L; Xiao L; Yim M; Chang M; Papa N; Bolton D; Shulkes A; Baldwin GS; Patel O
[Ad] Endereço:Department of Surgery, The University of Melbourne Victoria, Australia.
[Ti] Título:Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent.
[So] Source:PLoS One;12(7):e0180028, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and chronic kidney disease. Two promising preconditioning methods for the kidney, intermittent arterial clamping (IC) and treatment with the hypoxia mimetic cobalt chloride, have never been directly compared. Furthermore, the protective efficacy of the chemically related transition metal Zn2+ against renal IRI is unclear. Although Co2+ ions have been shown to protect the kidney via hypoxia inducible factor (HIF), the effect of Zn2+ ions on the induction of HIF1α, HIF2α and HIF3α has not been investigated previously. MATERIALS AND METHODS: The efficacy of different preconditioning techniques was assessed using a Sprague-Dawley rat model of renal IRI. Induction of HIF proteins following Zn2+ treatment of the human kidney cell lines HK-2 (immortalized normal tubular cells) and ACHN (renal cancer) was measured using Western Blot. RESULTS: Following 40 minutes of renal ischemia in rats, cobalt preconditioning offered greater protection against renal IRI than IC as evidenced by lower peak serum creatinine and urea concentrations. ZnCl2 (10 mg/kg) significantly lowered the creatinine and urea concentrations compared to saline-treated control rats following a clinically relevant 60 minutes of ischemia. Zn2+ induced expression of HIF1α and HIF2α but not HIF3α in HK-2 and ACHN cells. CONCLUSION: ZnCl2 preconditioning protects against renal IRI in a dose-dependent manner. Further studies are warranted to determine the possible mechanisms involved, and to assess the benefit of ZnCl2 preconditioning for clinical applications.
[Mh] Termos MeSH primário: Lesão Renal Aguda/tratamento farmacológico
Fatores de Transcrição Hélice-Alça-Hélice Básicos/biossíntese
Subunidade alfa do Fator 1 Induzível por Hipóxia/biossíntese
Traumatismo por Reperfusão/tratamento farmacológico
Fatores de Transcrição/biossíntese
[Mh] Termos MeSH secundário: Lesão Renal Aguda/fisiopatologia
Animais
Fatores de Transcrição Hélice-Alça-Hélice Básicos/sangue
Linhagem Celular
Cloretos/administração & dosagem
Cobalto/administração & dosagem
Creatinina/sangue
Relação Dose-Resposta a Droga
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Subunidade alfa do Fator 1 Induzível por Hipóxia/sangue
Precondicionamento Isquêmico/métodos
Rim/efeitos dos fármacos
Rim/fisiopatologia
Ratos
Traumatismo por Reperfusão/sangue
Traumatismo por Reperfusão/fisiopatologia
Fatores de Transcrição/sangue
Ureia/sangue
Compostos de Zinco/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Chlorides); 0 (Hif1a protein, rat); 0 (Hif3a protein, rat); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (Transcription Factors); 0 (Zinc Compounds); 0 (endothelial PAS domain-containing protein 1); 3G0H8C9362 (Cobalt); 86Q357L16B (zinc chloride); 8W8T17847W (Urea); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180028


  9 / 4012 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28665969
[Au] Autor:Houston DMJ; Bugert JJ; Denyer SP; Heard CM
[Ad] Endereço:School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff Wales, United Kingdom.
[Ti] Título:Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV.
[So] Source:PLoS One;12(6):e0179291, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE) and co-administered zinc (II) ions. MATERIALS AND METHODS: PRE was used in conjunction with zinc (II) salts to challenge HSV-1 and aciclovir-resistant HSV in terms of virucidal plaque assay reduction and antiviral activities in epithelial Vero host cells. Cytotoxicity was determined by the MTS assay using a commercial kit. RESULTS: Zinc sulphate, zinc citrate, zinc stearate and zinc gluconate demonstrated similar potentiated virucidal activity with PRE against HSV-1 by up to 4-fold. A generally parabolic relationship was observed when HSV-1 was challenged with PRE and varying concentrations of ZnSO4, with a maximum potentiation factor of 5.5. Punicalagin had 8-fold greater virucidal activity than an equivalent mass of PRE. However, antiviral data showed that punicalagin had significantly lower antiviral activity compared to the activity of PRE (EC50 = 0.56 µg mL-1) a value comparable to aciclovir (EC50 = 0.18 µg mL-1); however, PRE also demonstrated potency against aciclovir-resistant HSV (EC50 = 0.02 µg mL-1), whereas aciclovir showed no activity. Antiviral action of PRE was not influenced by ZnSO4. No cytotoxicity was detected with any test solution. CONCLUSIONS: The potentiated virucidal activity of PRE by coadministered zinc (II) has potential as a multi-action novel topical therapeutic agent against HSV infections, such as coldsores.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Antivirais/farmacologia
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 2/efeitos dos fármacos
Extratos Vegetais/farmacologia
Punicaceae/química
Compostos de Zinco/farmacologia
[Mh] Termos MeSH secundário: Animais
Antivirais/administração & dosagem
Cercopithecus aethiops
Citotoxicidade Imunológica/efeitos dos fármacos
Farmacorresistência Viral
Sinergismo Farmacológico
Ácido Elágico/farmacologia
Herpesvirus Humano 1/crescimento & desenvolvimento
Herpesvirus Humano 2/crescimento & desenvolvimento
Extratos Vegetais/administração & dosagem
Células Vero
Ensaio de Placa Viral
Compostos de Zinco/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); 0 (Zinc Compounds); 19YRN3ZS9P (Ellagic Acid); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179291


  10 / 4012 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28628980
[Au] Autor:Wei W; Wu S
[Ad] Endereço:State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
[Ti] Título:Depolymerization of cellulose into high-value chemicals by using synergy of zinc chloride hydrate and sulfate ion promoted titania catalyst.
[So] Source:Bioresour Technol;241:760-766, 2017 Oct.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Experiments for cellulose depolymerization by synergy of zinc chloride hydrate (ZnCl ·RH O) and sulfated titania catalyst (SO /TiO ) were investigated in this study. The results showed the introduction of sulfate into the TiO significantly enhanced the catalyst acid amount, especially for Brønsted acid site, which is beneficial for subsequent cellulose depolymerization. ZnCl ·RH O hydrate, only a narrow composition range of water, specifically 3.0≤R≤4.0, can dissolve cellulose, which finally resulted the cellulose with low crystallinity and weak intrachain and interchain hydrogen bond network. Coupling of ZnCl ·RH O hydrate and SO /TiO catalyst as a mixed reaction system promoted cellulose depolymerization, and the products can be adjusted by the control of reaction conditions, the low temperature (80-100°C) seemed beneficial for glucose formation (maximal yield 50.5%), and the high temperature (120-140°C) favored to produce levulinic acid (maximal yield 43.1%). Besides, the addition of organic co-solvent making HMF as the main product (maximal yield 38.3%).
[Mh] Termos MeSH primário: Celulose
Cloretos
Compostos de Zinco
[Mh] Termos MeSH secundário: Catálise
Sulfatos
Temperatura Ambiente
Titânio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Sulfates); 0 (Zinc Compounds); 15FIX9V2JP (titanium dioxide); 86Q357L16B (zinc chloride); 9004-34-6 (Cellulose); D1JT611TNE (Titanium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE



página 1 de 402 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde