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[PMID]:28799204
[Au] Autor:Chen L; Li F; Zhang Y; Bentley CL; Horne M; Bond AM; Zhang J
[Ad] Endereço:School of Chemistry, Monash University, Clayton, Victoria, 3800, Australia.
[Ti] Título:Electrochemical Reduction of Carbon Dioxide in a Monoethanolamine Capture Medium.
[So] Source:ChemSusChem;10(20):4109-4118, 2017 Oct 23.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The electrocatalytic reduction of CO in a 30 % (w/w) monoethanolamine (MEA) aqueous solution was undertaken at In, Sn, Bi, Pb, Pd, Ag, Cu and Zn metal electrodes. Upon the dissolution of CO , the non-conducting MEA solution is transformed into a conducting one, as is required for the electrochemical reduction of CO . Both an increase in the electrode surface porosity and the addition of the surfactant cetyltrimethylammonium bromide (CTAB) suppress the competing hydrogen evolution reaction; the latter has a significantly stronger impact. The combination of a porous metal electrode and the addition of 0.1 % (w/w) CTAB results in the reduction of molecular CO to CO and formate ions, and the product distribution is highly dependent on the identity of the metal electrode used. At a potential of -0.8 V versus the reversible hydrogen electrode (RHE) with an indium electrode with a coralline-like structure, the faradaic efficiencies for the generation of CO and [HCOO] ions are 22.8 and 54.5 %, respectively compared to efficiencies of 2.9 and 60.8 % with a porous lead electrode and 38.2 and 2.4 % with a porous silver electrode. Extensive data for the other five electrodes are also provided. The optimal conditions for CO reduction are identified, and mechanistic details for the reaction pathways are proposed in this proof-of-concept electrochemical study in a CO capture medium. The conditions and features needed to achieve industrially and commercially viable CO reduction in an amine-based capture medium are considered.
[Mh] Termos MeSH primário: Dióxido de Carbono/química
Etanolamina/química
[Mh] Termos MeSH secundário: Eletroquímica
Eletrodos
Metais/química
Oxirredução
Porosidade
Propriedades de Superfície
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals); 0 (Surface-Active Agents); 142M471B3J (Carbon Dioxide); 5KV86114PT (Ethanolamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701075


  2 / 931 MEDLINE  
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[PMID]:28626133
[Au] Autor:Yu X; Wang N; Zhang R; Zhao Z
[Ad] Endereço:College of Food Science and Engineering, Northwest A&F University.
[Ti] Título:Simple Synthesis Hydrogenated Castor Oil Fatty Amide Wax and Its Coating Characterization.
[So] Source:J Oleo Sci;66(7):659-665, 2017 Jul 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A simple method for incorporating amine groups in hydrogenated castor oil (HCO) to produce wax for beeswax or carnauba wax substitution in packaging and coating was developed. From the conversion rate of the products, HCO was reacted with ethanolamine at 150°C for 5 h, and the molar ratio of HCO and ethanolamine was 1:4. The hardness of the final product was seven times higher than that of beeswax, the cohesiveness of the final product was 1.3 times higher than that of beeswax and approximately one half of that of carnauba wax, and the melting point of the final product is 98°C. The Fourier transform Infrared spectroscopy showed that the amide groups were incorporated to form the amide products. In coating application, the results showed that the force of the final product coating cardboard was higher than that of beeswax and paraffin wax and less than that of carnauba wax. After 24 h soaking, the compression forces were decreased. HCO fatty acid wax can be an alternative wax for carnauba wax and beeswax in coating applications.
[Mh] Termos MeSH primário: Amidas/síntese química
Óleo de Rícino/análogos & derivados
Fenômenos Químicos
Técnicas de Química Sintética/métodos
Etanolamina/química
Ceras/síntese química
[Mh] Termos MeSH secundário: Óleo de Rícino/química
Temperatura Alta
Hidrogenação
Espectroscopia de Infravermelho com Transformada de Fourier
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Waxes); 5KV86114PT (Ethanolamine); 61791-12-6 (polyethoxylated castor oil); 8001-79-4 (Castor Oil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16213


  3 / 931 MEDLINE  
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[PMID]:28409451
[Au] Autor:Honsho M; Fujiki Y
[Ad] Endereço:Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
[Ti] Título:Analysis of Plasmalogen Synthesis in Cultured Cells.
[So] Source:Methods Mol Biol;1595:55-61, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plasmalogen synthesis can be analyzed by metabolic labeling, followed by the separation of ethanolamine plasmalogens from glycerophospholipids on one-dimensional thin-layer chromatography. The vinyl-ether bond of plasmalogens is acid-labile, which allows separating plasmalogens as 2-acyl-glycerophospholipids from diacyl-glycerophospholipids.
[Mh] Termos MeSH primário: Plasmalogênios/biossíntese
[Mh] Termos MeSH secundário: Radioisótopos de Carbono
Linhagem Celular
Células Cultivadas
Etanolamina/química
Etanolamina/metabolismo
Marcação por Isótopo
Ácido Palmítico/química
Compostos de Vinila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 0 (Plasmalogens); 0 (Vinyl Compounds); 2H2T044E11 (vinyl ether); 2V16EO95H1 (Palmitic Acid); 5KV86114PT (Ethanolamine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6937-1_6


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[PMID]:28385597
[Au] Autor:Ferrara SJ; Meinig JM; Placzek AT; Banerji T; McTigue P; Hartley MD; Sanford-Crane HS; Banerji T; Bourdette D; Scanlan TS
[Ad] Endereço:Program in Chemical Biology, Department of Physiology & Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
[Ti] Título:Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration.
[So] Source:Bioorg Med Chem;25(10):2743-2753, 2017 May 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Current therapeutic options for treating demyelinating disorders such as multiple sclerosis (MS) do not stimulate myelin repair, thus creating a clinical need for therapeutic agents that address axonal remyelination. Thyroid hormone is known to play an important role in promoting developmental myelination and repair, and CNS permeable thyromimetic agents could offer an increased therapeutic index compared to endogenous thyroid hormone. Sobetirome is a clinical stage thyromimetic that has been shown to have promising activity in preclinical models related to MS and X-linked adrenoleukodystrophy (X-ALD), a genetic disease that involves demyelination. Here we report a new series of sobetirome prodrugs containing ethanolamine-based promoieties that were found to undergo an intramolecular O,N acyl migration to form the pharmacologically relevant amide species. Several of these systemically administered prodrugs deliver more sobetirome to the brain compared to unmodified sobetirome. Pharmacokinetic properties of the parent drug sobetirome and amidoalcohol prodrug 3 are described and prodrug 3 was found to be more potent than sobetirome in target engagement in the brain from systemic dosing.
[Mh] Termos MeSH primário: Acetatos/química
Barreira Hematoencefálica/metabolismo
Etanolamina/química
Fenóis/química
[Mh] Termos MeSH secundário: Administração Oral
Amidas/química
Animais
Área Sob a Curva
Encéfalo/metabolismo
Ésteres/química
Meia-Vida
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Pró-Fármacos/síntese química
Pró-Fármacos/química
Pró-Fármacos/farmacocinética
Curva ROC
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Amides); 0 (Esters); 0 (GC 1 compound); 0 (Phenols); 0 (Prodrugs); 5KV86114PT (Ethanolamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE


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[PMID]:28372221
[Au] Autor:Dong B; Shao X; Lin H; Hu J
[Ad] Endereço:Laboratory of Pesticide Residues and Environmental Toxicology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, PR China. Electronic address: idongbizhang@126.com.
[Ti] Título:Dissipation, residues and risk assessment of metaldehyde and niclosamide ethanolamine in pakchoi after field application.
[So] Source:Food Chem;229:604-609, 2017 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A method using LC-MS/MS after QuEChERS preparation for the simultaneous determination of metaldehyde and niclosamide ethanolamine residues in soil and pakchoi has been developed and validated. The mean recoveries were ranged from 90% to 101% with RSDs (relative standard deviations) less than 9.2%. The dissipation results showed that the half-lives of metaldehyde and niclosamide ethanolamine were 2.3-4.3d and 1.7-9.5d, respectively. The terminal residue results indicated that the residues of metaldehyde in pakchoi were lower than the temporary maximum residue limits (MRL) set by China on 1 d after last treatment and the maximum residue of niclosamide ethanolamine in pakchoi was 0.54mg/kg. The risk quotients of metaldehyde and niclosamide ethanolamine were ranged from 0.015 to 0.033 and from 0.00064 to 0.0014, respectively. This work could provide guidance on reasonable use of these molluscicides and aid in the establishment of MRL in China.
[Mh] Termos MeSH primário: Acetaldeído/análogos & derivados
Brassica/química
Etanolamina/química
Niclosamida/química
[Mh] Termos MeSH secundário: Acetaldeído/química
Medição de Risco
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 4CI033VJYG (metaldehyde); 5KV86114PT (Ethanolamine); 8KK8CQ2K8G (Niclosamide); GO1N1ZPR3B (Acetaldehyde)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


  6 / 931 MEDLINE  
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[PMID]:28298227
[Au] Autor:Battini S; Faitot F; Imperiale A; Cicek AE; Heimburger C; Averous G; Bachellier P; Namer IJ
[Ad] Endereço:ICube, UMR 7357 University of Strasbourg/CNRS, Strasbourg, France.
[Ti] Título:Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients.
[So] Source:BMC Med;15(1):56, 2017 Mar 16.
[Is] ISSN:1741-7015
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study were to (1) describe the metabolome of pancreatic parenchyma (PP) and PA, (2) determine the impact of neoadjuvant chemotherapy on PP and PA, and (3) find tissue metabolic biomarkers associated with long-term survivors, using metabolomics analysis. METHODS: H high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy using intact tissues was applied to analyze metabolites in PP tissue samples (n = 17) and intact tumor samples (n = 106), obtained from 106 patients undergoing surgical resection for PA. RESULTS: An orthogonal partial least square-discriminant analysis (OPLS-DA) showed a clear distinction between PP and PA. Higher concentrations of myo-inositol and glycerol were shown in PP, whereas higher levels of glucose, ascorbate, ethanolamine, lactate, and taurine were revealed in PA. Among those metabolites, one of them was particularly obvious in the distinction between long-term and short-term survivors. A high ethanolamine level was associated with worse survival. The impact of neoadjuvant chemotherapy was higher on PA than on PP. CONCLUSIONS: This study shows that HRMAS NMR spectroscopy using intact tissue provides important and solid information in the characterization of PA. Metabolomics profiling can also predict long-term survival: the assessment of ethanolamine concentration can be clinically relevant as a single metabolic biomarker. This information can be obtained in 20 min, during surgery, to distinguish long-term from short-term survival.
[Mh] Termos MeSH primário: Adenocarcinoma/metabolismo
Quimioterapia Adjuvante/métodos
Etanolamina/metabolismo
Metabolômica/métodos
Pâncreas
Neoplasias Pancreáticas/metabolismo
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adenocarcinoma/terapia
Idoso
Biomarcadores/metabolismo
Análise Discriminante
Feminino
Seres Humanos
Espectroscopia de Ressonância Magnética/métodos
Masculino
Meia-Idade
Pâncreas/metabolismo
Pâncreas/patologia
Neoplasias Pancreáticas/patologia
Neoplasias Pancreáticas/terapia
Prognóstico
Sobreviventes/estatística & dados numéricos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 5KV86114PT (Ethanolamine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1186/s12916-017-0810-z


  7 / 931 MEDLINE  
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[PMID]:28284560
[Au] Autor:Chen B; Wei W; Ma L; Yang B; Gill RM; Chua MS; Butte AJ; So S
[Ad] Endereço:Institute for Computational Health Sciences and Department of Pediatrics, University of California, San Francisco, California.
[Ti] Título:Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
[So] Source:Gastroenterology;152(8):2022-2036, 2017 Jun.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: Drug repositioning offers a shorter approval process than new drug development. We therefore searched large public datasets of drug-induced gene expression signatures to identify agents that might be effective against hepatocellular carcinoma (HCC). METHODS: We searched public databases of messenger RNA expression patterns reported from HCC specimens from patients, HCC cell lines, and cells exposed to various drugs. We identified drugs that might specifically increase expression of genes that are down-regulated in HCCs and reduce expression of genes up-regulated in HCCs using a nonparametric, rank-based pattern-matching strategy based on the Kolmogorov-Smirnov statistic. We evaluated the anti-tumor activity of niclosamide and its ethanolamine salt (NEN) in HCC cell lines (HepG2, Huh7, Hep3B, Hep40, and PLC/PRF/5), primary human hepatocytes, and 2 mouse models of HCC. In one model of HCC, liver tumor development was induced by hydrodynamic delivery of a sleeping beauty transposon expressing an activated form of Ras (v12) and truncated ß-catenin (N90). In another mouse model, patient-derived xenografts were established by implanting HCC cells from patients into livers of immunocompromised mice. Tumor growth was monitored by bioluminescence imaging. Tumor-bearing mice were fed a regular chow diet or a chow diet containing niclosamide or NEN. In a separate experiment using patient-derived xenografts, tumor-bearing mice were given sorafenib (the standard of care for patients with advanced HCC), NEN, or niclosamide alone; a combination of sorafenib and NEN; or a combination sorafenib and niclosamide in their drinking water, or regular water (control), and tumor growth was monitored. RESULTS: Based on gene expression signatures, we identified 3 anthelmintics that significantly altered the expression of genes that are up- or down-regulated in HCCs. Niclosamide and NEN specifically reduced the viability of HCC cells: the agents were at least 7-fold more cytotoxic to HCCs than primary hepatocytes. Oral administration of NEN to mice significantly slowed growth of genetically induced liver tumors and patient-derived xenografts, whereas niclosamide did not, coinciding with the observed greater bioavailability of NEN compared with niclosamide. The combination of NEN and sorafenib was more effective at slowing growth of patient-derived xenografts than either agent alone. In HepG2 cells and in patient-derived xenografts, administration of niclosamide or NEN increased expression of 20 genes down-regulated in HCC and reduced expression of 29 genes up-regulated in the 274-gene HCC signature. Administration of NEN to mice with patient-derived xenografts reduced expression of proteins in the Wnt-ß-catenin, signal transducer and activator of transcription 3, AKT-mechanistic target of rapamycin, epidermal growth factor receptor-Ras-Raf signaling pathways. Using immunoprecipitation assays, we found NEN to bind cell division cycle 37 protein and disrupt its interaction with heat shock protein 90. CONCLUSIONS: In a bioinformatics search for agents that alter the HCC-specific gene expression pattern, we identified the anthelmintic niclosamide as a potential anti-tumor agent. Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice. Both agents disrupted interaction between cell division cycle 37 and heat shock protein 90 in HCC cells, with concomitant inhibition of their downstream signaling pathways. NEN might be effective for treatment of patients with HCC.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Carcinoma Hepatocelular/tratamento farmacológico
Proteínas de Ciclo Celular/antagonistas & inibidores
Proliferação Celular/efeitos dos fármacos
Chaperoninas/antagonistas & inibidores
Simulação por Computador
Descoberta de Drogas/métodos
Reposicionamento de Medicamentos
Etanolamina/farmacologia
Neoplasias Hepáticas/tratamento farmacológico
Chaperonas Moleculares/antagonistas & inibidores
Niclosamida/farmacologia
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
Carcinoma Hepatocelular/genética
Carcinoma Hepatocelular/metabolismo
Carcinoma Hepatocelular/patologia
Proteínas de Ciclo Celular/genética
Proteínas de Ciclo Celular/metabolismo
Chaperoninas/genética
Chaperoninas/metabolismo
Biologia Computacional
Bases de Dados Genéticas
Relação Dose-Resposta a Droga
Feminino
Perfilação da Expressão Gênica
Regulação Neoplásica da Expressão Gênica
Proteínas de Choque Térmico HSP90/metabolismo
Células Hep G2
Seres Humanos
Neoplasias Hepáticas/genética
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/patologia
Masculino
Chaperonas Moleculares/genética
Chaperonas Moleculares/metabolismo
Niacinamida/análogos & derivados
Niacinamida/farmacologia
Niclosamida/análogos & derivados
Compostos de Fenilureia/farmacologia
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
Transcriptoma
Carga Tumoral/efeitos dos fármacos
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (CDC37 protein, human); 0 (Cdc37 protein, mouse); 0 (Cell Cycle Proteins); 0 (HSP90 Heat-Shock Proteins); 0 (Molecular Chaperones); 0 (Phenylurea Compounds); 25X51I8RD4 (Niacinamide); 5KV86114PT (Ethanolamine); 8KK8CQ2K8G (Niclosamide); 9ZOQ3TZI87 (sorafenib); EC 3.6.1.- (Chaperonins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  8 / 931 MEDLINE  
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[PMID]:28125641
[Au] Autor:Engel N; Adamus A; Schauer N; Kühn J; Nebe B; Seitz G; Kraft K
[Ad] Endereço:Department of Pediatric Surgery, University Hospital Marburg, Baldingerstraße, Marburg, Germany.
[Ti] Título:Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation.
[So] Source:PLoS One;12(1):e0169742, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Phytoestrogens such as genistein, the most prominent isoflavone from soy, show concentration-dependent anti-estrogenic or estrogenic effects. High genistein concentrations (>10 µM) also promote proliferation of bone cancer cells in vitro. On the other hand, the most active component of the vitamin D family, calcitriol, has been shown to be tumor protective in vitro and in vivo. The purpose of this study was to examine a putative synergism of genistein and calcitriol in two osteosarcoma cell lines MG-63 (early osteoblast), Saos-2 (mature osteoblast) and primary osteoblasts. METHODS: Thus, an initial screening based on cell cycle phase alterations, estrogen (ER) and vitamin D receptor (VDR) expression, live cell metabolic monitoring, and metabolomics were performed. RESULTS: Exposure to the combination of 100 µM genistein and 10 nM calcitriol reduced the number of proliferative cells to control levels, increased ERß and VDR expression, and reduced extracellular acidification (40%) as well as respiratory activity (70%), primarily in MG-63 cells. In order to identify the underlying cellular mechanisms in the MG-63 cell line, metabolic profiling via GC/MS technology was conducted. Combined treatment significantly influenced lipids and amino acids preferably, whereas metabolites of the energy metabolism were not altered. The comparative analysis of the log2-ratios revealed that after combined treatment only the metabolite ethanolamine was highly up-regulated. This is the result: a strong overexpression (350%) of the enzyme sphingosine-1-phosphate lyase (SGPL1), which irreversibly degrades sphingosine-1-phosphate (S1P), thereby, generating ethanolamine. S1P production and secretion is associated with an increased capability of migration and invasion of cancer cells. CONCLUSION: From these results can be concluded that the tumor promoting effect of high concentrations of genistein in immature osteosarcoma cells is reduced by the co-administration of calcitriol, primarily by the breakdown of S1P. It should be tested whether this anti-metastatic pathway can be stimulated by combined treatment also in metastatic xenograft mice models.
[Mh] Termos MeSH primário: Aldeído Liases/biossíntese
Calcitriol/administração & dosagem
Receptor beta de Estrogênio/biossíntese
Genisteína/administração & dosagem
Osteossarcoma/tratamento farmacológico
Receptores de Calcitriol/biossíntese
[Mh] Termos MeSH secundário: Aldeído Liases/genética
Animais
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sinergismo Farmacológico
Receptor beta de Estrogênio/genética
Etanolamina/metabolismo
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Lisofosfolipídeos/metabolismo
Camundongos
Osteoblastos/efeitos dos fármacos
Osteoblastos/metabolismo
Osteossarcoma/metabolismo
Osteossarcoma/patologia
Fitoestrógenos/administração & dosagem
Receptores de Calcitriol/genética
Esfingosina/análogos & derivados
Esfingosina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogen Receptor beta); 0 (Lysophospholipids); 0 (Phytoestrogens); 0 (Receptors, Calcitriol); 0 (VDR protein, human); 26993-30-6 (sphingosine 1-phosphate); 5KV86114PT (Ethanolamine); DH2M523P0H (Genistein); EC 4.1.2.- (Aldehyde-Lyases); EC 4.1.2.27 (sphingosine 1-phosphate lyase (aldolase)); FXC9231JVH (Calcitriol); NGZ37HRE42 (Sphingosine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169742


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[PMID]:27935700
[Au] Autor:van der Giesen C; Meinrenken CJ; Kleijn R; Sprecher B; Lackner KS; Kramer GJ
[Ad] Endereço:Institute of Environmental Science, Leiden University , P.O. Box 9518, 2300 RA Leiden, The Netherlands.
[Ti] Título:A Life Cycle Assessment Case Study of Coal-Fired Electricity Generation with Humidity Swing Direct Air Capture of CO versus MEA-Based Postcombustion Capture.
[So] Source:Environ Sci Technol;51(2):1024-1034, 2017 Jan 17.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most carbon capture and storage (CCS) envisions capturing CO from flue gas. Direct air capture (DAC) of CO has hitherto been deemed unviable because of the higher energy associated with capture at low atmospheric concentrations. We present a Life Cycle Assessment of coal-fired electricity generation that compares monoethanolamine (MEA)-based postcombustion capture (PCC) of CO with distributed, humidity-swing-based direct air capture (HS-DAC). Given suitable temperature, humidity, wind, and water availability, HS-DAC can be largely passive. Comparing energy requirements of HS-DAC and MEA-PCC, we find that the parasitic load of HS-DAC is less than twice that of MEA-PCC (60-72 kJ/mol versus 33-46 kJ/mol, respectively). We also compare other environmental impacts as a function of net greenhouse gas (GHG) mitigation: To achieve the same 73% mitigation as MEA-PCC, HS-DAC would increase nine other environmental impacts by on average 38%, whereas MEA-PCC would increase them by 31%. Powering distributed HS-DAC with photovoltaics (instead of coal) while including recapture of all background GHG, reduces this increase to 18%, hypothetically enabling coal-based electricity with net-zero life-cycle GHG. We conclude that, in suitable geographies, HS-DAC can complement MEA-PCC to enable CO capture independent of time and location of emissions and recapture background GHG from fossil-based electricity beyond flue stack emissions.
[Mh] Termos MeSH primário: Carvão Mineral
Etanolamina
[Mh] Termos MeSH secundário: Eletricidade
Umidade
Centrais Elétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coal); 5KV86114PT (Ethanolamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.6b05028


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[PMID]:27864129
[Au] Autor:Reis CL; Silva LM; Rodrigues TH; Félix AK; Santiago-Aguiar RS; Canuto KM; Rocha MV
[Ad] Endereço:Departamento de Engenharia Química, Universidade Federal do Ceará, Campus do Pici, Bloco 709, Fortaleza, CE, Brazil.
[Ti] Título:Pretreatment of cashew apple bagasse using protic ionic liquids: Enhanced enzymatic hydrolysis.
[So] Source:Bioresour Technol;224:694-701, 2017 Jan.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To enhance the enzymatic digestibility of cashew apple bagasse (CAB) feedstock in order to produce sugar fermentation-derived bioproducts, the CAB was subjected to three different pretreatments with the ionic liquid 2-hydroxyl-ethylammonium acetate (2-HEAA) and characterized by FTIR, NMR and chemical methods. All conditions were able to delignify CAB, however the best lignin removal (95.8%) was achieved through the method performed with 8.7% w/w of CAB/2-HEAA ratio at 130°C for 24h. Although the cellulose crystallinity has been increased in CAB treated with the ionic liquid, but this fact did not influence its digestibility. Nevertheless, the pretreatment with 2-HEAA enhanced significantly the cellulose digestibility, increasing the glucose yield from 48 to 747.72mg /g . Furthermore, 2-HEAA pretreatment was efficient even with reused ionic liquid, obtaining high glucose concentration.
[Mh] Termos MeSH primário: Anacardium/química
Biotecnologia/métodos
Líquidos Iônicos/química
[Mh] Termos MeSH secundário: Acetatos/química
Anacardium/metabolismo
Celulase/química
Celulase/metabolismo
Celulose/química
Celulose/metabolismo
Etanolamina/química
Glucose/química
Glucose/metabolismo
Hidrólise
Resíduos Industriais
Lignina/química
Espectroscopia de Ressonância Magnética
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Industrial Waste); 0 (Ionic Liquids); 5KV86114PT (Ethanolamine); 9004-34-6 (Cellulose); 9005-53-2 (Lignin); 9006-97-7 (bagasse); EC 3.2.1.4 (Cellulase); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE



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