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[PMID]:27246939
[Au] Autor:Phan TD; Kluger R; Wan C
[Ad] Endereço:Staff Specialist Anaesthetist, Department of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria.
[Ti] Título:Minimally invasive cardiac output monitoring: agreement of oesophageal Doppler, LiDCOrapid™ and Vigileo FloTrac™ monitors in non-cardiac surgery.
[So] Source:Anaesth Intensive Care;44(3):382-90, 2016 May.
[Is] ISSN:0310-057X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:There is lack of data about the agreement of minimally invasive cardiac output monitors, which make it impossible to determine if they are interchangeable or differ objectively in tracking physiological trends. We studied three commonly used devices: the oesophageal Doppler and two arterial pressure-based devices, the Vigileo FloTrac™ and LiDCOrapid™. The aim of this study was to compare the agreement of these three monitors in adult patients undergoing elective non-cardiac surgery. Measurements were taken at baseline and after predefined clinical interventions of fluid, metaraminol or ephedrine bolus. From 24 patients, 131 events, averaging 5.2 events per patient, were analysed. The cardiac index of LiDCOrapid versus FloTrac had a mean bias of -6.0% (limits of agreement from -51% to 39%) and concordance of over 80% to the three clinical interventions. The cardiac index of Doppler versus LiDCOrapid and Doppler versus FloTrac, had an increasing negative bias at higher mean cardiac outputs and there was significantly poorer concordance to all interventions. Of the preload-responsive parameters, Doppler stroke volume index, Doppler systolic flow time and FloTrac stroke volume variation were fair at predicting fluid responsiveness while other parameters were poor. While there is reasonable agreement between the two arterial pressure-derived cardiac output devices (LiDCOrapid and Vigileo FloTrac), these two devices differ significantly to the oesophageal Doppler technology in response to common clinical intraoperative interventions, representing a limitation to how interchangeable these technologies are in measuring cardiac output.
[Mh] Termos MeSH primário: Débito Cardíaco/fisiologia
Ecocardiografia Doppler/métodos
Procedimentos Cirúrgicos Eletivos/métodos
Monitorização Intraoperatória/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Efedrina/administração & dosagem
Feminino
Seres Humanos
Masculino
Metaraminol/administração & dosagem
Meia-Idade
Estudos Prospectivos
Volume Sistólico/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
818U2PZ2EH (Metaraminol); GN83C131XS (Ephedrine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE


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[PMID]:26858092
[Au] Autor:Darvall J; Vijayakumar R; Leslie K
[Ad] Endereço:Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia. jai.darvall@mh.org.au.
[Ti] Título:Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial.
[So] Source:Can J Anaesth;63(5):577-83, 2016 May.
[Is] ISSN:1496-8975
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Prewarming prior to surgery is effective in preventing perioperative hypothermia. There is a paucity of evidence, however, regarding the hemodynamic effects of prewarming. We hypothesized that the nadir mean arterial pressure during anesthesia induction would be higher after prewarming than after no prewarming. METHODS: We randomized 32 patients prior to elective neurosurgery to receive either one hour of forced-air convective warming at 46°C or routine care (full body blanket with convective warmer attached but not turned on). All patients had invasive blood pressure, heart rate, and core temperature monitoring before and during warming and underwent a protocolized intravenous anesthetic induction with propofol and remifentanil target-controlled infusions. The primary endpoint was the nadir mean arterial blood pressure (MAP) during induction. Hypotension was defined as systolic blood pressure (SBP) < 90 mmHg, MAP < 60 mmHg, or a reduction in either SBP or MAP > 20% from baseline values. RESULTS: No difference was found in the mean (SD) nadir MAP between the prewarmed group and the control group [64 (11) mmHg vs 68 (16) mmHg, respectively; mean difference, 5 mmHg; 95% confidence interval (CI), -6 to 15; P = 0.36]. Similarly, there was no difference between groups in the incidence of hypotension (100% of prewarmed vs 93% of control patients; relative risk, 1.07; 95% CI, 0.94 to 1.23; P = 0.32) or in the requirement for vasopressors during induction (four patients in each group required metaraminol; P = 1.00). CONCLUSION: Prewarming with convective forced air for one hour prior to intravenous anesthetic induction did not prevent hypotension during the induction period (Australian New Zealand Clinical Trials Registry [ANZCTR] ACTRN12615000431527).
[Mh] Termos MeSH primário: Anestésicos Intravenosos/administração & dosagem
Hipotensão/prevenção & controle
Hipotermia/prevenção & controle
Procedimentos Neurocirúrgicos/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Pressão Sanguínea/fisiologia
Temperatura Corporal/fisiologia
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Hipotensão/epidemiologia
Incidência
Masculino
Metaraminol/administração & dosagem
Meia-Idade
Piperidinas/administração & dosagem
Propofol/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Piperidines); 818U2PZ2EH (Metaraminol); P10582JYYK (remifentanil); YI7VU623SF (Propofol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE
[do] DOI:10.1007/s12630-016-0601-6


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[PMID]:26476127
[Au] Autor:Rashmi M; Swati D
[Ad] Endereço:Department of Bioinformatics, MMV, Banaras Hindu University, Varanasi 221005, India. Electronic address: mayankrashmi6@gmail.com.
[Ti] Título:In silico drug re-purposing against African sleeping sickness using GlcNAc-PI de-N-acetylase as an experimental target.
[So] Source:Comput Biol Chem;59 Pt A:87-94, 2015 Dec.
[Is] ISSN:1476-928X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trypanosoma brucei is a protozoan that causes African sleeping sickness in humans. Many glycoconjugate compounds are present on the entire cell surface of Trypanosoma brucei to control the infectivity and survival of this pathogen. These gycoconjugates are anchored to the plasma membrane with the help of glycosyl phosphatidyl inositol (GPI) anchors. This type of anchor is much more common in protozoans than in other eukaryotes. The second step of glycosyl phosphatidyl inositol (GPI) anchor biosynthesis is catalyzed by an enzyme, which is GlcNAc-PI de-N-acetylase. GlcNAc-PI de-N-acetylase has a conserved GPI domain, which is responsible for the functionality of this enzyme. In this study, the three-dimensional structure of the target is modelled by I-TASSER and the ligand is modelled by PRODRG server. It is found that the predicted active site residues of the GPI domain are ultra-conserved for the Trypanosomatidae family. The predicted active site residues are His41, Pro42, Asp43, Asp44, Met47, Phe48, Ser74, Arg80, His103, Val144, Ser145, His147 and His150. Two hydrogen bond acceptors and four hydrogen bond donors are found in the modelled pharmacophore. All compounds of the Drugbank database and twenty three known inhibitors have been considered for structure based virtual screening. This work is focused on approved drugs because they are already tested for safety and effectiveness in humans. After the structure-based virtual screening, seventeen approved drugs and two inhibitors are found, which interact with the ligand on the basis of the designed pharmacophore. The docking has been performed for the resultant seventeen approved drugs and two known inhibitors. Two approved drugs have negative binding energy and their pKa values are similar to the selected known inhibitors. The result of this study suggests that the approved drugs Ethambutol (DB00330) and Metaraminol (DB00610) may prove useful in the treatment of African sleeping sickness.
[Mh] Termos MeSH primário: Amidoidrolases/antagonistas & inibidores
Antimaláricos/farmacologia
Simulação por Computador
Reposicionamento de Medicamentos
Inibidores Enzimáticos/farmacologia
Trypanosoma brucei brucei/efeitos dos fármacos
Tripanossomíase Africana/tratamento farmacológico
[Mh] Termos MeSH secundário: Amidoidrolases/metabolismo
Antimaláricos/química
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/química
Etambutol/química
Etambutol/farmacologia
Seres Humanos
Metaraminol/química
Metaraminol/farmacologia
Modelos Moleculares
Testes de Sensibilidade Parasitária
Relação Estrutura-Atividade
Trypanosoma brucei brucei/citologia
Trypanosoma brucei brucei/enzimologia
Tripanossomíase Africana/enzimologia
Tripanossomíase Africana/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Enzyme Inhibitors); 818U2PZ2EH (Metaraminol); 8G167061QZ (Ethambutol); EC 3.5.- (Amidohydrolases); EC 3.5.1.89 (N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151217
[Lr] Data última revisão:
151217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151018
[St] Status:MEDLINE


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[PMID]:25702757
[Au] Autor:Lorigados CB; Ariga SK; Batista TR; Velasco IT; Soriano FG
[Ad] Endereço:Institute of Orthopaedics and Traumatology, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. gsoriano@usp.br.
[Ti] Título:Endotoxaemic myocardial dysfunction: the role of coronary driving pressure in subendocardial perfusion.
[So] Source:Crit Care Resusc;17(1):12-22, 2015 Mar.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the role of coronary driving pressure (CDP) in myocardial microcirculatory blood flow during sepsis. We hypothesised that in septic shock there is an impaired autoregulation of microcirculation, and blood flow is totally dependent on CDP. We analysed the effect of lipopolysaccharide (LPS)-induced shock on myocardial microcirculation, separating subendocardial and epicardial areas. We then studied the effect of CDP increases using noradrenaline (NOR) or metaraminol (Aramine [ARA]) on myocardial microcirculation and function, and we analysed the effect of volume infusion on CDP and myocardial function. DESIGN AND SETTING: Endotoxaemia was induced in male Wistar rats by an intraperitoneal injection of LPS 10 mg/kg. Animals were divided into a control (CT) group, an LPS-injected group, and an LPS-injected group treated with saline fluid, NOR or ARA. MAIN OUTCOME MEASURES: Ninety minutes later, a haemodynamic evaluation was performed. NOR or ARA were used to manage the mean arterial pressure (MAP) and CDP, and we inserted a catheter into the left ventricle to measure cardiac parameters. To measure blood flow in the myocardium and other organs, microspheres were introduced into the left ventricle using an infusion pump. RESULTS: After LPS treatment, left ventricular (LV) systolic function (dP/dt max) and diastolic function (dP/dt min) decreased by 34% and 15%, respectively, and load-independent indices (LV contractility in ejection phase and dP/dt max÷end-diastolic volume) were reduced. The CDP was also reduced (by 58%) in the endotoxaemic rats. Myocardial blood flow was reduced (by 80%) in animals with an MAP≤65 mmHg. NOR increased the CDP (LPS, 38 mmHg [SEM, 2 mmHg]; LPS+NOR, 59 mmHg [SEM, 3 mmHg]) and microcirculatory perfusion (LPS, 2 mL/min/g tissue [SEM, 0.6 mL/min/g]; LPS+NOR, 6.2 mL/min/g [SEM, 0.8 mL/min/g]). ARA was also effective in improve microcirculation but saline volume infusion was ineffective in improving CDP or myocardial function. CDP showed a significant correlation with subendocardial blood flow. CONCLUSIONS: Myocardial blood flow in the LV subendocardium and the right ventricle decreases in endotoxaemic rats. Increasing CDP improves myocardial blood flow and function. Thus, in endotoxaemia, microcirculatory blood flow is pressure dependent, suggesting that it may be beneficial to treat patients with sepsis using a higher CDP.
[Mh] Termos MeSH primário: Vasos Coronários/fisiopatologia
Coração/fisiopatologia
Choque Séptico/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Circulação Coronária/fisiologia
Endotoxemia/fisiopatologia
Hemodinâmica/fisiologia
Masculino
Metaraminol/farmacologia
Microcirculação/fisiologia
Norepinefrina/farmacologia
Ratos
Ratos Wistar
Função Ventricular Esquerda/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
818U2PZ2EH (Metaraminol); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150223
[Lr] Data última revisão:
150223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150224
[St] Status:MEDLINE


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[PMID]:23404978
[Au] Autor:Redmond M; Knapp C; Salim M; Shanbhag S; Jaumdally R
[Ti] Título:Use of vasopressors in Takotsubo cardiomyopathy: a cautionary tale.
[So] Source:Br J Anaesth;110(3):487-8, 2013 Mar.
[Is] ISSN:1471-6771
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cardiomiopatia de Takotsubo/tratamento farmacológico
Vasoconstritores/efeitos adversos
Vasoconstritores/uso terapêutico
[Mh] Termos MeSH secundário: Agonistas alfa-Adrenérgicos/efeitos adversos
Agonistas alfa-Adrenérgicos/uso terapêutico
Úlcera Duodenal/complicações
Eletrocardiografia
Feminino
Seres Humanos
Metaraminol/efeitos adversos
Metaraminol/uso terapêutico
Meia-Idade
Infarto do Miocárdio/complicações
Úlcera Péptica Perfurada/complicações
Choque/complicações
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Adrenergic alpha-Agonists); 0 (Vasoconstrictor Agents); 818U2PZ2EH (Metaraminol)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130214
[St] Status:MEDLINE
[do] DOI:10.1093/bja/aes586


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[PMID]:22913922
[Au] Autor:Bishop SM; Yarham SI; Navapurkar VU; Menon DK; Ercole A
[Ad] Endereço:Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
[Ti] Título:Multifractal analysis of hemodynamic behavior: intraoperative instability and its pharmacological manipulation.
[So] Source:Anesthesiology;117(4):810-21, 2012 Oct.
[Is] ISSN:1528-1175
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Physiologic instability is a common clinical problem in the critically ill. Many natural feedback systems are nonlinear, and seemingly random fluctuations may result from the amplification of external perturbations or even arise de novo as a consequence of their underlying dynamics. Characterization of the underlying nonlinear state may be of clinical importance, providing a technique to monitor complex physiology in real-time, guiding patient care and improving outcomes. METHODS: We employ the wavelet modulus maxima technique to characterize the multifractal properties of heart rate and mean arterial pressure physiology retrospectively for four patients during open abdominal aortic aneurysm repair. We calculated point-estimates for the dominant Hölder exponent (hm, hm) and multifractal spectrum width-at-half-height for both heart rate and mean arterial pressure signals. We investigated how these parameters changed with the administration of an intravenous vasoconstrictor and examined how this varied with atropine pretreatment. RESULTS: Hypotensive patients showed lower values of hm, consistent with a more highly fluctuating and complex behavior. Treatment with a vasoconstrictor led to a transient increase in hm, revealing the appearance of longer-range correlations, but did not impact hm. On the other hand, prior treatment with atropine had no effect on hm behavior but did tend to increase hm. CONCLUSIONS: Hypotension leads to a reduction in dominant Hölder exponents for mean arterial pressure, demonstrating an increasing signal complexity consistent with the activation of important homeokinetic processes. Conversely, pharmacological interventions may also alter the underlying dynamics. Pharmacological restoration of homeostasis leads to system decomplexification, suggesting that homeokinetic mechanisms are derecruited as homeostasis is restored.
[Mh] Termos MeSH primário: Fractais
Hemodinâmica/efeitos dos fármacos
Hemodinâmica/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Aneurisma Aórtico/cirurgia
Atropina/farmacologia
Pressão Sanguínea/efeitos dos fármacos
Pressão Sanguínea/fisiologia
Interpretação Estatística de Dados
Feminino
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Seres Humanos
Hipotensão/fisiopatologia
Período Intraoperatório
Masculino
Metaraminol/farmacologia
Monitorização Intraoperatória
Antagonistas Muscarínicos/farmacologia
Estudos Retrospectivos
Vasoconstrição/efeitos dos fármacos
Vasoconstrição/fisiologia
Análise de Ondaletas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Muscarinic Antagonists); 7C0697DR9I (Atropine); 818U2PZ2EH (Metaraminol)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:120824
[St] Status:MEDLINE


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[PMID]:22489799
[Au] Autor:Lim E; Dokos S; Salamonsen RF; Rosenfeldt FL; Ayre PJ; Lovell NH
[Ad] Endereço:Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. einly_lim@um.edu.my
[Ti] Título:Numerical optimization studies of cardiovascular-rotary blood pump interaction.
[So] Source:Artif Organs;36(5):E110-24, 2012 May.
[Is] ISSN:1525-1594
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A heart-pump interaction model has been developed based on animal experimental measurements obtained with a rotary blood pump in situ. Five canine experiments were performed to investigate the interaction between the cardiovascular system and the implantable rotary blood pump over a wide range of operating conditions, including variations in cardiac contractility and heart rate, systemic vascular resistance (SVR), and total blood volume (V(total) ). It was observed in our experiments that SVR decreased with increasing mean pump speed under the healthy condition, but was relatively constant during the speed ramp study under reduced cardiac contractility conditions. Furthermore, we also found a significant increase in pulmonary vascular resistance with increasing mean pump speed and decreasing total blood volume, despite a relatively constant SVR. Least squares parameter estimation methods were utilized to fit a subset of model parameters in order to achieve better agreement with the experimental data and to evaluate the robustness and validity of the model under various operating conditions. The fitted model produced reasonable agreement with the experimental measurements, both in terms of mean values and steady-state waveforms. In addition, all the optimized parameters were within physiological limits.
[Mh] Termos MeSH primário: Volume Sanguíneo
Frequência Cardíaca
Coração Auxiliar
Modelos Cardiovasculares
Contração Miocárdica
Resistência Vascular
[Mh] Termos MeSH secundário: Agonistas de Receptores Adrenérgicos alfa 1/farmacologia
Antagonistas de Receptores Adrenérgicos beta 1/farmacologia
Animais
Cães
Insuficiência Cardíaca/terapia
Seres Humanos
Análise dos Mínimos Quadrados
Metaraminol/farmacologia
Metoprolol/farmacologia
Nitroprussiato/farmacologia
Substitutos do Plasma
Poligelina
Vasodilatadores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic alpha-1 Receptor Agonists); 0 (Adrenergic beta-1 Receptor Antagonists); 0 (Plasma Substitutes); 0 (Vasodilator Agents); 169D1260KM (Nitroprusside); 818U2PZ2EH (Metaraminol); 9015-56-9 (Polygeline); GEB06NHM23 (Metoprolol)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120412
[St] Status:MEDLINE
[do] DOI:10.1111/j.1525-1594.2012.01449.x


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[PMID]:22165352
[Au] Autor:Phan TD; Kluger R; Wan C; Wong D; Padayachee A
[Ad] Endereço:Department of Anaesthesia, St Vincent's Hospital, Fitzroy, Victoria, Australia. tuong.phan@svhm.org.au
[Ti] Título:A comparison of three minimally invasive cardiac output devices with thermodilution in elective cardiac surgery.
[So] Source:Anaesth Intensive Care;39(6):1014-21, 2011 Nov.
[Is] ISSN:0310-057X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:This study compared the cardiac output responses to haemodynamic interventions as measured by three minimally invasive monitors (Oesophageal Doppler Monitor the VigileoFlotrac and the LiDCOrapid) to the responses measured concurrently using thermodilution, in cardiac surgical patients. The study also assessed the precision and bias of these monitors in relation to thermodilution measurements. After a fluid bolus of at least 250 ml, the measured change in cardiac output was different among the devices, showing an increase with thermodilution in 82% of measurements, Oesophageal Doppler Monitor 68%, VigileoFlotrac 57% and LiDCOrapid 41%. When comparing the test devices to thermodilution, the kappa statistic showed at best only fair agreement, Oesophageal Doppler Monitor 0.34, LiDCOrapid 0.28 and VigileoFlotrac -0.03. After vasopressor administration, there was also significant variation in the change in cardiac output measured by the devices. Using Bland-Altman analysis, the precision of the devices in comparison to thermodilution showed minimal bias, but wide limits of agreement with percentage errors of Oesophageal Doppler Monitor 64.5%, VigileoFlotrac 47.6% and LiDCOrapid 54.2%. These findings indicate that these three devices differ in their responses, do not always provide the same information as thermodilution and should not be used interchangeably to track cardiac output changes.
[Mh] Termos MeSH primário: Débito Cardíaco/fisiologia
Procedimentos Cirúrgicos Cardíacos/métodos
Monitorização Intraoperatória/métodos
Termodiluição
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea/efeitos dos fármacos
Procedimentos Cirúrgicos Eletivos
Hemodinâmica/efeitos dos fármacos
Hemodinâmica/fisiologia
Seres Humanos
Metaraminol/farmacologia
Monitorização Intraoperatória/instrumentação
Reprodutibilidade dos Testes
Vasoconstritores/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Vasoconstrictor Agents); 818U2PZ2EH (Metaraminol)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111215
[St] Status:MEDLINE


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[PMID]:21641198
[Au] Autor:Yamaguchi ET; Cardoso MM; Torres ML; Nascimento RC; Ribeiro MC; Frerichs E; Payen D
[Ad] Endereço:Department of Anesthesiology, Academic Hospital of University of São Paulo, São Paulo, Brazil. edu115@uol.com.br
[Ti] Título:Serum oxytocin concentrations in elective caesarean delivery: a randomized comparison of three infusion regimens.
[So] Source:Int J Obstet Anesth;20(3):224-8, 2011 Jul.
[Is] ISSN:1532-3374
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to determine serum oxytocin concentrations following different regimens of prophylactic oxytocin administration in women undergoing elective caesarean delivery. METHODS: Thirty healthy pregnant patients were randomized, after clamping of the umbilical cord, to receive intravenous oxytocin in one of the following groups: G1 (n=9), 10 IU of oxytocin infused over 30 min (0.33 IU/min); G2 (n=11), 10 IU of oxytocin infused over 3 min and 45 s (2.67 IU/min); and G3 (n=10), 80 IU of oxytocin infused over 30 min (2.67 IU/min). Both patient and surgeon were blinded to allocation. Uterine tone was assessed by surgical palpation. Serum oxytocin concentration was determined by enzyme immunoassay before anaesthesia (T0) and at 5 (T5), 30 (T30) and 60 (T60) min after the start of oxytocin infusion. RESULTS: Serum oxytocin concentrations (mean±standard error, ng/mL) were not significantly different in the groups at T0 (0.06±0.02, 0.04±0.02 and 0.07±0.04, respectively, P=0.76), and T60 (0.65±0.26, 0.36±0.26 and 0.69±0.26, respectively, P=0.58). G3 showed higher concentrations than G1 at T5 (3.65±0.74 versus 0.71±0.27, P=0.01) and at T30 (6.19±1.19 versus 1.17±0.37, P<0.01), and were higher than G2 at T30 (6.19±1.19 versus 0.41±0.2, P<0.01). Haemodynamic data and uterine tone were considered satisfactory and similar in all groups. No additional uterotonic agents were needed. CONCLUSION: Serum oxytocin measurements made using enzyme immunoassay in healthy pregnant women undergoing elective caesarean delivery showed that administration of 80 IU oxytocin over 30 min resulted in higher serum oxytocin levels after 5 and 30 min than the two other regimens. The concentrations did not differ between groups at 60 min.
[Mh] Termos MeSH primário: Cesárea
Ocitócicos/administração & dosagem
Ocitócicos/sangue
Ocitocina/administração & dosagem
Ocitocina/sangue
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea/fisiologia
Cromatografia de Afinidade
Parto Obstétrico
Método Duplo-Cego
Feminino
Frequência Cardíaca/fisiologia
Hematócrito
Seres Humanos
Técnicas Imunoenzimáticas
Infusões Intravenosas
Metaraminol/administração & dosagem
Metaraminol/uso terapêutico
Monitorização Intraoperatória
Gravidez
Vasoconstritores/administração & dosagem
Vasoconstritores/uso terapêutico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Oxytocics); 0 (Vasoconstrictor Agents); 50-56-6 (Oxytocin); 818U2PZ2EH (Metaraminol)
[Em] Mês de entrada:1110
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110607
[St] Status:MEDLINE
[do] DOI:10.1016/j.ijoa.2011.03.004


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[PMID]:21381427
[Au] Autor:Huang Y; Zhang X; Zhan C; Chen G
[Ad] Endereço:College of Chemistry and Materials Sciences, Fujian Normal University, Fuzhou 350108, China. huangying@fjnu.edu.cn
[Ti] Título:[Determination of three adrenergic drugs using capillary electrophoresis with amperometric detection].
[So] Source:Se Pu;28(11):1084-8, 2010 Nov.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A method for the determination of three adrenergic drugs, including phenylephrine hydrochloride (PHE), metaraminol bitartrate (MR) and isoprenaline hydrochloride (IP), was developed using capillary electrophoresis with amperometric detection. The detection potential of working electrode was 0.950 V versus the reference electrode of Ag/AgCl. At the applied voltage of 18 kV, the three analytes were completely separated within 18 min in 50 mmol/L borate buffer (pH 10.00) with the injection time of 10 s. Good linear relationships were obtained for all the three analytes in the range of 2-100 micromol/L. The detection limits for PHE, MR and IP were 0.8, 0.8 and 1.0 micromol/L, respectively. The proposed method was applied to the analysis of some injection drugs, and the results were satisfactory.
[Mh] Termos MeSH primário: Agonistas Adrenérgicos/análise
Eletroforese Capilar/métodos
[Mh] Termos MeSH secundário: Eletroquímica/métodos
Isoproterenol/análise
Metaraminol/análise
Fenilefrina/análise
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic Agonists); 1WS297W6MV (Phenylephrine); 818U2PZ2EH (Metaraminol); L628TT009W (Isoproterenol)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110309
[St] Status:MEDLINE



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