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[PMID]: | 28768500 |
[Au] Autor: | Rolle T; Spinetta R; Nuzzi R |
[Ad] Endereço: | Eye Clinic, Department of Surgical Sciences, University of Torino, Via Juvarra 19, 10122, Torino, Italy. teresa.rolle@unito.it. |
[Ti] Título: | Long term safety and tolerability of Tafluprost 0.0015% vs Timolol 0.1% preservative-free in ocular hypertensive and in primary open-angle glaucoma patients: a cross sectional study. |
[So] Source: | BMC Ophthalmol;17(1):136, 2017 Aug 03. | [Is] ISSN: | 1471-2415 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: The effects of preservatives of antiglaucoma medications on corneal surface and tear function have been widely shown in literature; it's not the same as regards the active compounds themselves. The purpose of our study was to compare Ocular Surface Disease (OSD) signs and symptoms of Tafluprost 0.0015% versus preservative free (PF) Timolol 0.1% eyedrops in ocular hypertensive (OH) and in primary open-angle glaucoma (POAG) patients. METHODS: A cross-sectional study included patients in monotherapy for at least 36 months with Tafluprost 0.0015% (27) or PF Timolol 0.1% (24) and 20 healthy age and sex-matched volunteers. All subjects underwent clinical tests (Schirmer I and break-up time), in vivo confocal microscopy (IVCM) and were surveyed using Ocular Surface Disease Index (OSDI) and Glaucoma Symptoms Scale (GSS) questionnaires. The groups were compared with ANOVA, Kruskal-Wallis test, t-test, Mann-Whitney test and Bonferroni's adjustment of p-values. RESULTS: No significant differences were found in questionnaires scores, clinical tests, IVCM variables between therapy groups. Tafluprost 0.0015% group showed significantly higher OSDI score, basal epithelial cells density, stromal reflectivity, sub-basal nerves tortuosity (p = 0.0000, 0.037, 0.006, 0.0000) and less GSS score, number of sub-basal nerves (p = 0.0000, 0.037) than controls but similar clinical tests results (p > 0.05). PF Timolol group had significantly higher OSDI score, basal epithelial cells density, stromal reflectivity and sub-basal nerve tortuosity (p = 0.000, 0.014, 0.008, 0.002), less GSS score, BUT and number of sub-basal nerves (p = 0.0000, 0.026, 0.003) than controls. CONCLUSIONS: Compared to PF Timolol 0.1%, Tafluprost 0.0015% showed similar safety with regards to tear function and corneal status and a similar tolerability profile. Both therapy groups show some alterations in corneal microstructure but no side effects on tear function except for an increased tear instability in PF Timolol 0.1% group. Ophtalmologists should be aware that even PF formulations may lead to a mild ocular surface impairment. |
[Mh] Termos MeSH primário: |
Tolerância a Medicamentos Glaucoma de Ângulo Aberto/tratamento farmacológico Pressão Intraocular/efeitos dos fármacos Hipertensão Ocular/tratamento farmacológico Prostaglandinas F/administração & dosagem Timolol/administração & dosagem
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[Mh] Termos MeSH secundário: |
Idoso Anti-Hipertensivos/administração & dosagem Estudos Transversais Relação Dose-Resposta a Droga Feminino Seguimentos Glaucoma de Ângulo Aberto/fisiopatologia Seres Humanos Masculino Microscopia Confocal Meia-Idade Hipertensão Ocular/fisiopatologia Soluções Oftálmicas Conservantes Farmacêuticos Lágrimas/química Fatores de Tempo Tonometria Ocular Resultado do Tratamento
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Antihypertensive Agents); 0 (Ophthalmic Solutions); 0 (Preservatives, Pharmaceutical); 0 (Prostaglandins F); 1O6WQ6T7G3 (tafluprost); 817W3C6175 (Timolol) |
[Em] Mês de entrada: | 1711 |
[Cu] Atualização por classe: | 171116 |
[Lr] Data última revisão:
| 171116 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170804 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1186/s12886-017-0534-z |
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