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[PMID]:15062601
[Au] Autor:Lee-Chiong T; Matthay RA
[Ad] Endereço:Section of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. lee-chiongt@njc.org
[Ti] Título:Drug-induced pulmonary edema and acute respiratory distress syndrome.
[So] Source:Clin Chest Med;25(1):95-104, 2004 Mar.
[Is] ISSN:0272-5231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Noncardiogenic pulmonary edema, and, to a lesser extent, acute respiratory distress syndrome (ARDS), are common clinical manifestations of drug-induced lung diseases. Clinical features and radiographic appearances are generally indistinguishable from other causes of pulmonary edema and ARDS. Typical manifestations include dyspnea, chest discomfort, tachypnea, and hypoxemia. Chest radiographs commonly reveal interstitial and alveolar filling infiltrates. Unlike pulmonary edema that is due to congestive heart failure, cardiomegaly and pulmonary vascular redistribution are generally absent in cases that are drug-related. Rare cases of drug-induced myocarditis with heart failure and pulmonary edema have been described. Results from laboratory evaluation and respiratory function tests are nonspecific.
[Mh] Termos MeSH primário: Edema Pulmonar/induzido quimicamente
Síndrome do Desconforto Respiratório do Adulto/induzido quimicamente
[Mh] Termos MeSH secundário: Antineoplásicos/efeitos adversos
Clorotiazida/efeitos adversos
Meios de Contraste
Diuréticos
Etclorvinol/efeitos adversos
Seres Humanos
Hipnóticos e Sedativos/efeitos adversos
Doença Iatrogênica
Imunossupressores/efeitos adversos
Pulmão/efeitos dos fármacos
Inibidores de Simportadores de Cloreto de Sódio/efeitos adversos
Tocolíticos/efeitos adversos
Tretinoína/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Contrast Media); 0 (Diuretics); 0 (Hypnotics and Sedatives); 0 (Immunosuppressive Agents); 0 (Sodium Chloride Symporter Inhibitors); 0 (Tocolytic Agents); 5688UTC01R (Tretinoin); 6EIM3851UZ (Ethchlorvynol); 77W477J15H (Chlorothiazide)
[Em] Mês de entrada:0408
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040406
[St] Status:MEDLINE


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[PMID]:10932303
[Ti] Título:Hypnotic drugs.
[So] Source:Med Lett Drugs Ther;42(1084):71-2, 2000 Aug 07.
[Is] ISSN:0025-732X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hipnóticos e Sedativos/uso terapêutico
[Mh] Termos MeSH secundário: Acetamidas/administração & dosagem
Acetamidas/uso terapêutico
Administração Oral
Consumo de Bebidas Alcoólicas
Barbitúricos/uso terapêutico
Hidrato de Cloral/uso terapêutico
Etclorvinol/efeitos adversos
Etclorvinol/uso terapêutico
Agonistas de Receptores de GABA-A
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Melatonina/uso terapêutico
Fitoterapia
Piridinas/uso terapêutico
Pirimidinas/administração & dosagem
Pirimidinas/uso terapêutico
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetamides); 0 (Barbiturates); 0 (GABA-A Receptor Agonists); 0 (Histamine H1 Antagonists); 0 (Hypnotics and Sedatives); 0 (Pyridines); 0 (Pyrimidines); 418M5916WG (Chloral Hydrate); 6EIM3851UZ (Ethchlorvynol); 7K383OQI23 (zolpidem); JL5DK93RCL (Melatonin); S62U433RMH (zaleplon)
[Em] Mês de entrada:0008
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:000810
[St] Status:MEDLINE


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[PMID]:8967376
[Au] Autor:Stephenson AH; Sprague RS; Weintraub NL; McMurdo L; Lonigro AJ
[Ad] Endereço:Department of Pharmacological and Physiological Science, Saint Louis University, School of Medicine, Missouri 63104, USA.
[Ti] Título:Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs.
[So] Source:Am J Physiol;270(4 Pt 2):H1355-62, 1996 Apr.
[Is] ISSN:0002-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The intravenous administration of ethchlorvynol (ECV), in dogs, resulted in an acute lung injury (ALI) characterized by a 200 +/- 80% increase in venous admixture and a 142 +/- 30% increase in extravascular lung water (EVLW). Pretreatment with the cytochrome P-450 inhibitor 8-methoxypsoralen prevented the ECV-induced increase in venous admixture but not the increased EVLW. These findings parallel those reported for cyclooxygenase inhibition in ECV-induced ALI and suggest that an arachidonic acid (AA) metabolite of pulmonary cytochrome P-450 activity may mediate the increase in venous admixture of ALI. We demonstrate that canine pulmonary microsomes metabolize [1-(14)C]AA to a variety of products, including the cytochrome P-450 metabolites 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid (EET). In prostaglandin F2 alpha-contracted, isolated pulmonary venous rings, 5,6-EET induced relaxation in a concentration-dependent manner. This action of 5,6-EET was prevented by indomethacin (10(-5) M). These results suggest that may serve as the cyclooxygenase-dependent endogenous pulmonary vasodilator responsible for the increase in venous admixture of ECV-induced ALI.
[Mh] Termos MeSH primário: Inibidores das Enzimas do Citocromo P-450
Hipóxia/etiologia
Hipóxia/fisiopatologia
Lesão Pulmonar
[Mh] Termos MeSH secundário: Ácido 8,11,14-Eicosatrienoico/análogos & derivados
Ácido 8,11,14-Eicosatrienoico/metabolismo
Ácido 8,11,14-Eicosatrienoico/farmacologia
Animais
Dinoprosta/farmacologia
Cães
Etclorvinol/farmacologia
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Masculino
Metoxaleno/farmacologia
Microssomos/metabolismo
Veículos Farmacêuticos/farmacologia
Vasoconstrição/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Pharmaceutical Vehicles); 6EIM3851UZ (Ethchlorvynol); 7324-41-6 (8,11,14-Eicosatrienoic Acid); 81246-84-6 (5,6-epoxy-8,11,14-eicosatrienoic acid); B7IN85G1HY (Dinoprost); U4VJ29L7BQ (Methoxsalen)
[Em] Mês de entrada:9612
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960401
[St] Status:MEDLINE


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[PMID]:8868143
[Au] Autor:Sprague RS; Stephenson AH; McMurdo L; Lonigro AJ
[Ad] Endereço:Department of Medicine, Saint Louis University School of Medicine, Missouri, USA 63104.
[Ti] Título:Inhibition of nitric oxide synthesis improves arterial oxygenation in ethchlorvynol-induced acute lung injury in dogs.
[So] Source:Pol J Pharmacol;47(5):473-8, 1995 Sep-Oct.
[Is] ISSN:1230-6002
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:In both humans and in experimental animals, acute lung injury (ALI) is characterized by the development of pulmonary edema and arterial hypoxemia. It has been reported that the hypoxemia of ALI is related to the failure of those mechanisms that result in the diversion of blood flow away from hypoxic (edematous) lung units to those that are well oxygenated. One such mechanism is hypoxic pulmonary vasoconstriction (HPV). In the pulmonary circulation, endogenous nitric oxide (NO) has been shown to oppose HPV and, thereby, to support blood flow to hypoxic alveoli. In the present work we investigated the hypothesis that, in ALI, endogenous NO, by virtue of its ability to oppose HPV, supports blood flow to hypoxic lung units resulting in increases in venous admixture (Qva/Qt) and decreases in arterial oxygen tension (PaO2). In anesthetized and mechanically ventilated dogs, the intravenous administration of ethchlorvynol (ECV, 15 mg/kg) resulted in an increase in extravascular lung water (EVLW) of 10 +/- 1 ml/kg body wt (p < 0.001) as well as a 120 +/- 45% increase in Qva/Qt (p < 0.01) and a 23 +/- 5% decrease in PaO2 (p < 0.01) (n = 3). L-NAME (1 mg/kg iv, followed by 5 mg/kg/h, iv), administrated 60 min after ethchlorvynol (ECV), prevented entirely the ECV-induced increase in Qva/Qt and fall in PaO2 with minimal effect on EVLW (n = 3). We conclude that, in this model of ALI, endogenous NO is present in the lung and acts to support blood flow to poorly oxygenated lung units resulting, thereby, in reductions in PaO2.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/uso terapêutico
Pneumopatias/metabolismo
NG-Nitroarginina Metil Éster/uso terapêutico
Óxido Nítrico Sintase/antagonistas & inibidores
Óxido Nítrico/biossíntese
Oxigênio/sangue
[Mh] Termos MeSH secundário: Animais
Gasometria
Cães
Etclorvinol
Água Extravascular Pulmonar/efeitos dos fármacos
Hemodinâmica/efeitos dos fármacos
Hipóxia/fisiopatologia
Pneumopatias/sangue
Pneumopatias/induzido quimicamente
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 31C4KY9ESH (Nitric Oxide); 6EIM3851UZ (Ethchlorvynol); EC 1.14.13.39 (Nitric Oxide Synthase); S88TT14065 (Oxygen); V55S2QJN2X (NG-Nitroarginine Methyl Ester)
[Em] Mês de entrada:9611
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950901
[St] Status:MEDLINE


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[PMID]:8447214
[Au] Autor:Nakatsuka M; Gehr LC; Glauser FL
[Ad] Endereço:Department of Anesthesiology, Medical College of Virginia, Virginia Commonwealth University, Richmond.
[Ti] Título:The effects of amrinone and calcium chloride on pulmonary vasculature and biventricular function in ethchlorvynol-induced lung injury in sheep.
[So] Source:Acta Anaesthesiol Scand;37(2):219-22, 1993 Feb.
[Is] ISSN:0001-5172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of amrinone and CaCl2 on pulmonary vasculature and biventricular function in sheep with acute lung injury (ALI) were studied. Seven sheep were ventilated with a tidal volume of 10-12 ml.kg-1 with end-tidal CO2 of 40 +/- 5 mmHg (5.3 +/- 0.7 kPa) after acute lung injury was induced with up to 30 mg kg-1 of ethchlorvynol (ECV). Biventricular function and hemodynamic profiles were estimated with a rapid computerized thermodilution method and modified pulmonary artery catheters after acute lung injury, following a loading dose (1 mg kg-1) and maintenance dose (5 micrograms kg-1 min-1) of amrinone and after a bolus dose of CaCl2 (20 mg kg-1). ECV successfully induced acute lung damage in sheep, causing significant increases in pulmonary artery pressure (PAP) and pulmonary vascular resistance index (PVRI). Amrinone reversed the unfavorable changes induced by ECV, significantly reducing PAP, PVRI and left ventricular end-diastolic volume (LVEDV). CaCl2, however, reversed the effect of amrinone and increased PAP, PVRI, and LVEDV but decreased left ventricular ejection fraction.
[Mh] Termos MeSH primário: Amrinona/farmacologia
Cloreto de Cálcio/farmacologia
Etclorvinol/efeitos adversos
Pulmão/irrigação sanguínea
Edema Pulmonar/induzido quimicamente
Edema Pulmonar/fisiopatologia
Função Ventricular Esquerda/efeitos dos fármacos
Função Ventricular Direita/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/efeitos dos fármacos
Débito Cardíaco/efeitos dos fármacos
Volume Cardíaco/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Artéria Pulmonar
Pressão Propulsora Pulmonar/efeitos dos fármacos
Ovinos
Volume Sistólico/efeitos dos fármacos
Resistência Vascular/efeitos dos fármacos
Função Ventricular Esquerda/fisiologia
Função Ventricular Direita/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
6EIM3851UZ (Ethchlorvynol); JUT23379TN (Amrinone); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:9304
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930201
[St] Status:MEDLINE


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[PMID]:7692773
[Au] Autor:Tanaka H; Dahms TE; Bell E; Naunheim KS; Baudendistel LJ
[Ad] Endereço:Department of Anesthesiology, St. Louis University School of Medicine, Missouri 63110.
[Ti] Título:Effect of hydroxyethyl starch on alveolar flooding in acute lung injury in dogs.
[So] Source:Am Rev Respir Dis;148(4 Pt 1):852-9, 1993 Oct.
[Is] ISSN:0003-0805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The efficacy of hydroxyethyl starch (HES) in limiting alveolar flooding after acute lung injury was investigated using ethchlorvynol (ECV)-induced low pressure pulmonary edema in dogs. Harvested autologous plasma (PL) (control, n = 8) or 6% HES (n = 8) was infused (25 ml/kg) along with packed cells to result in an isovolemic, normochromic preparation before the administration of ECV. Extravascular thermal volume significantly increased after ECV administration in both groups of animals (6.6 to 13.4 ml/kg in PL, 6.5 to 15.0 ml/kg in HES). Systemic arterial PO2 decreased from 216 +/- 4 to 113 +/- 20 mm Hg, and venous admixture increased from 2.8 to 12.8% in the PL group but was not significantly changed in the HES group (219 +/- 5 to 203 +/- 8 mm Hg, and 2.9 to 4.4%, respectively). Epithelial lining fluid volumes after ECV administration increased in both groups but were elevated in the PL group to a greater extent than in the HES group (13.5 ml in HES versus 24.8 ml in PL). In the HES group there appeared to be no difference in the ability of plasma proteins to move across the alveolar epithelium. These results suggest that HES attenuates the flooding of the alveolar space and the resulting alterations in gas exchange during the development of low pressure pulmonary edema. The replacement of the plasma proteins with HES and the apparent inability of HES to cross the epithelial barrier into the alveoli may account for the protective effect of HES in these experiments.
[Mh] Termos MeSH primário: Derivados de Hidroxietil Amido/uso terapêutico
Alvéolos Pulmonares/efeitos dos fármacos
Edema Pulmonar/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Análise de Variância
Animais
Gasometria
Líquido da Lavagem Broncoalveolar/química
Modelos Animais de Doenças
Cães
Avaliação Pré-Clínica de Medicamentos
Etclorvinol
Água Extravascular Pulmonar/efeitos dos fármacos
Modelos Lineares
Masculino
Troca Plasmática
Alvéolos Pulmonares/fisiopatologia
Edema Pulmonar/induzido quimicamente
Edema Pulmonar/epidemiologia
Edema Pulmonar/fisiopatologia
Troca Gasosa Pulmonar/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Hydroxyethyl Starch Derivatives); 6EIM3851UZ (Ethchlorvynol)
[Em] Mês de entrada:9311
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:931001
[St] Status:MEDLINE


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[PMID]:1568970
[Au] Autor:Yagi K; Baudendistel LJ; Dahms TE
[Ad] Endereço:Department of Anesthesiology, St. Louis University School of Medicine, St. Louis 63110.
[Ti] Título:Ibuprofen reduces ethchlorvynol lung injury: possible role of blood flow distribution.
[So] Source:J Appl Physiol (1985);72(3):1156-65, 1992 Mar.
[Is] ISSN:8750-7587
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The role of cyclooxygenase products in acute lung injury was determined by pretreatment of dogs with ibuprofen before injury with intravenous ethchlovynol (ECV). In animals given ECV only, lung injury resulted in extravascular lung water of 18.9 ml/kg after 2 h, which was significantly higher than the 14.8 ml/kg in the group pretreated with ibuprofen. The comparison of gravimetric and indicator-dilution measurements of edema fluid indicates that edema fluid could not be reliably detected after treatment with ibuprofen because of diversion of flow from injured areas. Venous admixture increased from 6% at baseline to 32% 120 min after ECV in the vehicle-pretreated group compared with an increase from 4% at baseline to 7% in the ibuprofen-pretreated group. The regression analysis of the relationship between venous admixture and extravascular lung water indicated that, at any level of edema, venous admixture was significantly less in the group treated with ibuprofen than in the untreated group. Measurement of plasma and bronchoalveolar lavage fluid indicated that ibuprofen inhibited cyclooxygenase activity without affecting lipoxygenase activity. These results suggest that in intact dogs ibuprofen has a protective effect on both pulmonary gas transfer and pulmonary edema formation in ECV-injured lungs, which is consistent with limiting blood flow to injured segments of the lung.
[Mh] Termos MeSH primário: Etclorvinol/antagonistas & inibidores
Ibuprofeno/farmacologia
Lesão Pulmonar
[Mh] Termos MeSH secundário: Animais
Cães
Eicosanoides/metabolismo
Etclorvinol/toxicidade
Pulmão/irrigação sanguínea
Pulmão/fisiopatologia
Masculino
Prostaglandina-Endoperóxido Sintases/metabolismo
Circulação Pulmonar/efeitos dos fármacos
Edema Pulmonar/induzido quimicamente
Edema Pulmonar/fisiopatologia
Edema Pulmonar/prevenção & controle
Troca Gasosa Pulmonar/efeitos dos fármacos
Fluxo Sanguíneo Regional/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Eicosanoids); 6EIM3851UZ (Ethchlorvynol); EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:9205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920301
[St] Status:MEDLINE


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[PMID]:1506357
[Au] Autor:Blanch L; Roussos C; Brotherton S; Michel RP; Angle MR
[Ad] Endereço:Critical Care Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
[Ti] Título:Effect of tidal volume and PEEP in ethchlorvynol-induced asymmetric lung injury.
[So] Source:J Appl Physiol (1985);73(1):108-16, 1992 Jul.
[Is] ISSN:8750-7587
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We examined the effects of positive end-expiratory pressure (PEEP) and tidal volume on the distribution of ventilation and perfusion in a canine model of asymmetric lung injury. Unilateral right lung edema was established in 10 animals by use of a selective infusion of ethchlorvynol. Five animals were tested in the supine position (horizontal asymmetry) and five in the right decubitus position (vertical asymmetry). Raising PEEP from 5 to 12 cmH2O improved oxygenation despite a redistribution of blood flow toward the damage lung and a consistent decrease in total respiratory system compliance. This improvement paralleled a redistribution of tidal ventilation to the injured lung. This was effected primarily by a fall in the compliance of the noninjured lung due to hyperinflation. The effects of higher tidal volume were additive to those of PEEP. We propose that the major effect of PEEP in inhomogeneous lung injury is to restore tidal ventilation to a population of alveoli recruitable only at high airway pressures.
[Mh] Termos MeSH primário: Etclorvinol/toxicidade
Pneumopatias/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/fisiologia
Cães
Hemodinâmica/efeitos dos fármacos
Intubação Intratraqueal
Complacência Pulmonar/fisiologia
Pneumopatias/induzido quimicamente
Respiração com Pressão Positiva
Edema Pulmonar/metabolismo
Edema Pulmonar/fisiopatologia
Troca Gasosa Pulmonar/efeitos dos fármacos
Volume de Ventilação Pulmonar/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
6EIM3851UZ (Ethchlorvynol)
[Em] Mês de entrada:9209
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920701
[St] Status:MEDLINE


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[PMID]:1917763
[Au] Autor:Zanaboni PB; Bradley JD; Webster RO; Dahms TE
[Ad] Endereço:Department of Pharmacology, St Louis University School of Medicine, Missouri 63110.
[Ti] Título:Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs.
[So] Source:J Appl Physiol (1985);71(1):43-9, 1991 Jul.
[Is] ISSN:8750-7587
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of three chemically dissimilar cyclooxygenase inhibitors on ethchlorvynol-(ECV) induced acute lung injury was studied in isolated buffer-perfused rat and blood-perfused rabbit lungs. ECV caused the microvascular fluid filtration coefficient (Kf) to increase by greater than threefold in the rat lungs and twofold in the rabbit lungs. ECV caused increased pulmonary vascular resistance (PVR) and microvascular pressure measured by the double occlusion technique (Pdo) compared with the vehicle control group in the rat experiments. However, ECV had no effect on PVR or Pdo in the rabbit experiments. Pretreatment with the cyclooxygenase inhibitors indomethacin, ibuprofen, and meclofenamate prevented the increase in microvascular permeability in both the rat and rabbit lung preparations. The cyclooxygenase inhibitors also prevented the ECV-induced PVR and Pdo increases in the rat lungs but had no effect on PVR or Pdo in the rabbit lungs. These results indicate that cyclooxygenase products of arachidonate metabolism mediate the ECV-induced Kf increase in both isolated rat and rabbit lungs.
[Mh] Termos MeSH primário: Inibidores de Ciclo-Oxigenase/farmacologia
Etclorvinol/antagonistas & inibidores
Pneumopatias/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Permeabilidade Capilar/efeitos dos fármacos
Etclorvinol/toxicidade
Ibuprofeno/farmacologia
Técnicas In Vitro
Indometacina/farmacologia
Pneumopatias/induzido quimicamente
Masculino
Ácido Meclofenâmico/farmacologia
Circulação Pulmonar/efeitos dos fármacos
Coelhos
Ratos
Ratos Endogâmicos
Resistência Vascular/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Cyclooxygenase Inhibitors); 48I5LU4ZWD (Meclofenamic Acid); 6EIM3851UZ (Ethchlorvynol); WK2XYI10QM (Ibuprofen); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:9111
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910701
[St] Status:MEDLINE


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[PMID]:1914570
[Au] Autor:Reed CR; Glauser FL
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Medical College of Virginia, Richmond.
[Ti] Título:Drug-induced noncardiogenic pulmonary edema.
[So] Source:Chest;100(4):1120-4, 1991 Oct.
[Is] ISSN:0012-3692
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Edema Pulmonar/induzido quimicamente
Síndrome do Desconforto Respiratório do Adulto/induzido quimicamente
[Mh] Termos MeSH secundário: Permeabilidade Capilar/fisiologia
Etclorvinol/efeitos adversos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
6EIM3851UZ (Ethchlorvynol)
[Em] Mês de entrada:9111
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:911001
[St] Status:MEDLINE



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