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  1 / 3558 MEDLINE  
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[PMID]:29324854
[Au] Autor:Suroto DA; Kitani S; Arai M; Ikeda H; Nihira T
[Ad] Endereço:International Center for Biotechnology, Osaka University, Suita, Osaka, Japan.
[Ti] Título:Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis.
[So] Source:PLoS One;13(1):e0190973, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phthoxazolin A, an oxazole-containing polyketide, has a broad spectrum of anti-oomycete activity and herbicidal activity. We recently identified phthoxazolin A as a cryptic metabolite of Streptomyces avermitilis that produces the important anthelmintic agent avermectin. Even though genome data of S. avermitilis is publicly available, no plausible biosynthetic gene cluster for phthoxazolin A is apparent in the sequence data. Here, we identified and characterized the phthoxazolin A (ptx) biosynthetic gene cluster through genome sequencing, comparative genomic analysis, and gene disruption. Sequence analysis uncovered that the putative ptx biosynthetic genes are laid on an extra genomic region that is not found in the public database, and 8 open reading frames in the extra genomic region could be assigned roles in the biosynthesis of the oxazole ring, triene polyketide and carbamoyl moieties. Disruption of the ptxA gene encoding a discrete acyltransferase resulted in a complete loss of phthoxazolin A production, confirming that the trans-AT type I PKS system is responsible for the phthoxazolin A biosynthesis. Based on the predicted functional domains in the ptx assembly line, we propose the biosynthetic pathway of phthoxazolin A.
[Mh] Termos MeSH primário: Álcoois Graxos/metabolismo
Genes Bacterianos
Família Multigênica
Oxazóis/metabolismo
Alcamidas Poli-Insaturadas/metabolismo
Streptomyces/genética
[Mh] Termos MeSH secundário: Álcoois Graxos/química
Modelos Biológicos
Oxazóis/química
Alcamidas Poli-Insaturadas/química
Streptomyces/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Alcohols); 0 (Oxazoles); 0 (Polyunsaturated Alkamides); 130288-22-1 (phthoxazolin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190973


  2 / 3558 MEDLINE  
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[PMID]:28460114
[Au] Autor:Reynolds HT; Slot JC; Divon HH; Lysøe E; Proctor RH; Brown DW
[Ad] Endereço:Department of Plant Pathology, The Ohio State University, Columbus, OH.
[Ti] Título:Differential Retention of Gene Functions in a Secondary Metabolite Cluster.
[So] Source:Mol Biol Evol;34(8):2002-2015, 2017 Aug 01.
[Is] ISSN:1537-1719
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In fungi, distribution of secondary metabolite (SM) gene clusters is often associated with host- or environment-specific benefits provided by SMs. In the plant pathogen Alternaria brassicicola (Dothideomycetes), the DEP cluster confers an ability to synthesize the SM depudecin, a histone deacetylase inhibitor that contributes weakly to virulence. The DEP cluster includes genes encoding enzymes, a transporter, and a transcription regulator. We investigated the distribution and evolution of the DEP cluster in 585 fungal genomes and found a wide but sporadic distribution among Dothideomycetes, Sordariomycetes, and Eurotiomycetes. We confirmed DEP gene expression and depudecin production in one fungus, Fusarium langsethiae. Phylogenetic analyses suggested 6-10 horizontal gene transfers (HGTs) of the cluster, including a transfer that led to the presence of closely related cluster homologs in Alternaria and Fusarium. The analyses also indicated that HGTs were frequently followed by loss/pseudogenization of one or more DEP genes. Independent cluster inactivation was inferred in at least four fungal classes. Analyses of transitions among functional, pseudogenized, and absent states of DEP genes among Fusarium species suggest enzyme-encoding genes are lost at higher rates than the transporter (DEP3) and regulatory (DEP6) genes. The phenotype of an experimentally-induced DEP3 mutant of Fusarium did not support the hypothesis that selective retention of DEP3 and DEP6 protects fungi from exogenous depudecin. Together, the results suggest that HGT and gene loss have contributed significantly to DEP cluster distribution, and that some DEP genes provide a greater fitness benefit possibly due to a differential tendency to form network connections.
[Mh] Termos MeSH primário: Alcadienos/metabolismo
Compostos de Epóxi/metabolismo
Álcoois Graxos/metabolismo
Genoma Fúngico/genética
Família Multigênica/genética
[Mh] Termos MeSH secundário: Ascomicetos/genética
Bases de Dados de Ácidos Nucleicos
Evolução Molecular
Proteínas Fúngicas/genética
Fusarium/genética
Perfilação da Expressão Gênica/métodos
Regulação Fúngica da Expressão Gênica/genética
Transferência Genética Horizontal/genética
Filogenia
Metabolismo Secundário/genética
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkadienes); 0 (Epoxy Compounds); 0 (Fatty Alcohols); 0 (Fungal Proteins); 139508-73-9 (depudecin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/molbev/msx145


  3 / 3558 MEDLINE  
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[PMID]:28748934
[Au] Autor:Wu J; Lorenzo P; Zhong S; Ali M; Butts CP; Myers EL; Aggarwal VK
[Ad] Endereço:School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
[Ti] Título:Synergy of synthesis, computation and NMR reveals correct baulamycin structures.
[So] Source:Nature;547(7664):436-440, 2017 07 26.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Small-molecule, biologically active natural products continue to be our most rewarding source of, and inspiration for, new medicines. Sometimes we happen upon such molecules in minute quantities in unique, difficult-to-reach, and often fleeting environments, perhaps never to be discovered again. In these cases, determining the structure of a molecule-including assigning its relative and absolute configurations-is paramount, enabling one to understand its biological activity. Molecules that comprise stereochemically complex acyclic and conformationally flexible carbon chains make such a task extremely challenging. The baulamycins (A and B) serve as a contemporary example. Isolated in small quantities and shown to have promising antimicrobial activity, the structure of the conformationally flexible molecules was determined largely through J-based configurational analysis, but has been found to be incorrect. Our subsequent campaign to identify the true structures of the baulamycins has revealed a powerful method for the rapid structural elucidation of such molecules. Specifically, the prediction of nuclear magnetic resonance (NMR) parameters through density functional theory-combined with an efficient sequence of boron-based synthetic transformations, which allowed an encoded (labelled) mixture of natural-product diastereomers to be prepared-enabled us rapidly to pinpoint and synthesize the correct structures.
[Mh] Termos MeSH primário: Álcoois Graxos/química
Álcoois Graxos/síntese química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Resorcinóis/química
Resorcinóis/síntese química
[Mh] Termos MeSH secundário: Técnicas de Química Sintética
Modelos Moleculares
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Alcohols); 0 (Resorcinols); 0 (baulamycin A); 0 (baulamycin B)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1038/nature23265


  4 / 3558 MEDLINE  
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[PMID]:28745358
[Au] Autor:Zhang F; Thakur K; Hu F; Zhang JG; Wei ZJ
[Ad] Endereço:School of Food Science and Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China. china_zhangfang@163.com kumarikiran@hfut.edu.cn hufei@hfut.edu.cn zhangjianguo@hfut.edu.cn zjwei@hfut.edu.cn.
[Ti] Título:Cross-talk between 10-gingerol and its anti-cancerous potential: a recent update.
[So] Source:Food Funct;8(8):2635-2649, 2017 Aug 01.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Since time immortal, ginger, as an ancient herb, has been used throughout the world in foods and beverages due to its typical strong and pungent flavor. Besides its use as a spice, it also serves as an excellent source of several bioactive phenolics, including nonvolatile pungent compounds, such as gingerols, paradols, shogaols, and gingerones. Gingerols constitute key ingredients in fresh ginger, with the most abundant being 6-gingerol (6-G), 8-gingerol (8-G), and 10-gingerol (10-G). Many studies have investigated the various valuable pharmacological properties of these ingredients and experimentally verified the mechanistic aspects of their health effects; however, to date, most research on the anti-cancerous activities of gingerols have focused largely on 6-G. Thus, the present article deals with the number of recent studies that have indicated and highlighted the role of 10-G with respect to its cancer prevention attributes in particular and its anti-inflammatory, anti-oxidant, anti-microbial, and gastrointestinal tract protective potential in general. The purpose of this review is to provide an overview of all the experimentally validated health benefits of 10-G for nutraceutical applications. The various findings have warranted the further investigation of 10-G and its possible use in various cancer treatments as well as its promising role as a chemo-preventive agent.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Catecóis/farmacologia
Álcoois Graxos/farmacologia
Gengibre/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Catecóis/química
Suplementos Nutricionais/análise
Álcoois Graxos/química
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Catechols); 0 (Fatty Alcohols); 0 (Plant Extracts); 925QK2Z900 (gingerol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00844a


  5 / 3558 MEDLINE  
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[PMID]:29061506
[Au] Autor:Le HT; Nguyen HT; Min HY; Hyun SY; Kwon S; Lee Y; Le THV; Lee J; Park JH; Lee HY
[Ad] Endereço:Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
[Ti] Título:Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells.
[So] Source:Cancer Lett;412:297-307, 2018 Jan 01.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Cancer stem-like cells (CSCs) contribute to tumor recurrence and chemoresistance. Hence, strategies targeting CSCs are crucial for effective anticancer therapies. Here, we demonstrate the capacities of the non-saponin fraction of Panax ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of NSCLC in vitro and in vivo. Panaxynol inhibited the sphere forming ability of NSCLC CSCs at nanomolar concentrations, and micromolar concentrations of panaxynol suppressed the viability of NSCLC cells (non-CSCs) and their sublines carrying acquired chemoresistance with minimal effect on normal cells derived from various organs. Orally administered panaxynol significantly reduced lung tumorigenesis in Kras transgenic mice and mice carrying NSCLC xenografts without detectable toxicity. Mechanistically, panaxynol disrupted Hsp90 function by binding to the N-terminal and C-terminal ATP-binding pockets of Hsp90 without increasing Hsp70 expression. These data suggest the potential of panaxynol as a natural Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Di-Inos/farmacologia
Álcoois Graxos/farmacologia
Proteínas de Choque Térmico HSP90/antagonistas & inibidores
Neoplasias Pulmonares/tratamento farmacológico
Células-Tronco Neoplásicas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/metabolismo
Animais
Apoptose/efeitos dos fármacos
Carcinoma Pulmonar de Células não Pequenas/patologia
Linhagem Celular Tumoral
Proteínas de Choque Térmico HSP90/fisiologia
Seres Humanos
Neoplasias Pulmonares/patologia
Camundongos
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diynes); 0 (Fatty Alcohols); 0 (HSP90 Heat-Shock Proteins); 21852-80-2 (falcarinol); 8L70Q75FXE (Adenosine Triphosphate)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


  6 / 3558 MEDLINE  
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[PMID]:28873530
[Au] Autor:Si W; Chen YP; Zhang J; Chen ZY; Chung HY
[Ad] Endereço:Key Laboratory of Agricultural and Animal Products Processing and Quality Control, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China; Suzhou Polytechnic Institute of Agriculture, Suzhou, Jiangsu, China. Electronic address: swh8614@163.com.
[Ti] Título:Antioxidant activities of ginger extract and its constituents toward lipids.
[So] Source:Food Chem;239:1117-1125, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lipid oxidation-a major cause of food product deterioration-necessitates the use of food additives to inhibit food oxidation. Ginger extract (GE) has been reported to possess antioxidant properties. However, components isolated from ginger have been rarely reported to inhibit fat oxidation. Herein, antioxidant properties of GE and four pure components derived from it (6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol) were examined and their properties were compared to those of butylated hydroxytoluene. GE and the constituent components exhibited antioxidant properties that might be attributed to their hydroxyl groups and suitable solubilizing side chains. 6-Shogaol and 10-gingerol exhibited higher activity at 60°C than 6-gingerol and 8-gingerol. Low antioxidant activity was detected at high temperatures (120/180°C). Overall, GE displayed the strongest dose-dependent antioxidant properties, especially at high temperatures, thereby demonstrating that GE can be employed as a natural antioxidant in lipid-containing processed foods.
[Mh] Termos MeSH primário: Gengibre
[Mh] Termos MeSH secundário: Catecóis
Álcoois Graxos
Lipídeos
Extratos Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Fatty Alcohols); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  7 / 3558 MEDLINE  
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[PMID]:28793909
[Au] Autor:Samad MB; Mohsin MNAB; Razu BA; Hossain MT; Mahzabeen S; Unnoor N; Muna IA; Akhter F; Kabir AU; Hannan JMA
[Ad] Endereço:Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA. mehdi.samad@unmc.edu.
[Ti] Título:[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic ß-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr type 2 diabetic mice.
[So] Source:BMC Complement Altern Med;17(1):395, 2017 Aug 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Lepr diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of [6]-Gingerol and the mechanism(s) through which [6]-Gingerol ameliorates hyperglycemia. METHODS: Lepr type 2 diabetic mice were orally administered a daily dose of [6]-Gingerol (200 mg/kg) for 28 days. We measured the plasma levels of different endocrine hormones in fasting and fed conditions. GLP-1 levels were modulated using pharmacological approaches, and cAMP/PKA pathway for insulin secretion was assessed by qRT-PCR and ELISA in isolated pancreatic islets. Total skeletal muscle and its membrane fractions were used to measure glycogen synthase 1 level and Glut4 expression and protein levels. RESULTS: 4-weeks treatment of [6]-Gingerol dramatically increased glucose-stimulated insulin secretion and improved glucose tolerance. Plasma GLP-1 was found to be significantly elevated in the treated mice. Pharmacological intervention of GLP-1 levels regulated the effect of [6]-Gingerol on insulin secretion. Mechanistically, [6]-Gingerol treatment upregulated and activated cAMP, PKA, and CREB in the pancreatic islets, which are critical components of GLP-1-mediated insulin secretion pathway. [6]-Gingerol upregulated both Rab27a GTPase and its effector protein Slp4-a expression in isolated islets, which regulates the exocytosis of insulin-containing dense-core granules. [6]-Gingerol treatment improved skeletal glycogen storage by increased glycogen synthase 1 activity. Additionally, GLUT4 transporters were highly abundant in the membrane of the skeletal myocytes, which could be explained by the increased expression of Rab8 and Rab10 GTPases that are responsible for GLUT4 vesicle fusion to the membrane. CONCLUSIONS: Collectively, our study reports that GLP-1 mediates the insulinotropic activity of [6]-Gingerol, and [6]-Gingerol treatment facilitates glucose disposal in skeletal muscles through increased activity of glycogen synthase 1 and enhanced cell surface presentation of GLUT4 transporters.
[Mh] Termos MeSH primário: Catecóis/uso terapêutico
Álcoois Graxos/uso terapêutico
Gengibre/química
Transportador de Glucose Tipo 4/metabolismo
Hiperglicemia/tratamento farmacológico
Células Secretoras de Insulina/efeitos dos fármacos
Insulina/secreção
Músculo Esquelético/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Catecóis/farmacologia
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/tratamento farmacológico
Álcoois Graxos/farmacologia
Peptídeo 1 Semelhante ao Glucagon/sangue
Glicogênio/metabolismo
Glicogênio Sintase/metabolismo
Hiperglicemia/etiologia
Hiperglicemia/metabolismo
Células Secretoras de Insulina/metabolismo
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Endogâmicos NOD
Camundongos Knockout
Músculo Esquelético/metabolismo
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Via Secretória/efeitos dos fármacos
Proteínas de Transporte Vesicular/metabolismo
Proteínas rab de Ligação ao GTP/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Catechols); 0 (Fatty Alcohols); 0 (Glucose Transporter Type 4); 0 (Insulin); 0 (Membrane Proteins); 0 (Plant Extracts); 0 (Rab8 protein, mouse); 0 (Vesicular Transport Proteins); 89750-14-1 (Glucagon-Like Peptide 1); 9005-79-2 (Glycogen); 925QK2Z900 (gingerol); EC 2.4.1.11 (Glycogen Synthase); EC 3.6.1.- (Rab10 protein, mouse); EC 3.6.5.2 (rab GTP-Binding Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1903-0


  8 / 3558 MEDLINE  
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[PMID]:28789800
[Au] Autor:Peng LQ; Cao J; Du LJ; Zhang QD; Xu JJ; Chen YB; Shi YT; Li RR
[Ad] Endereço:College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
[Ti] Título:Rapid ultrasonic and microwave-assisted micellar extraction of zingiberone, shogaol and gingerols from gingers using biosurfactants.
[So] Source:J Chromatogr A;1515:37-44, 2017 Sep 15.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two kinds of extraction methods ultrasonic-assisted micellar extraction (UAME) and microwave-assisted micellar extraction (MAME) coupled with ultra-high performance liquid chromatography with ultraviolet detector (UHPLC-UV) were developed and evaluated for extraction and determination of zingerone, 6-gingerol, 8-gingerol, 6-shogaol and 10-gingerol in Rhizoma Zingiberis and Rhizoma Zingiberis Preparata. A biosurfactant, hyodeoxycholic acid sodium salt, was used in micellar extraction. Several experimental parameters were studied separately by a univariate method. The result indicated that the MAME was more efficient than UAME. The optimal conditions of MAME were as follows: 100mM of hyodeoxycholic acid sodium salt was used as surfactant, the irradiation time was set at 10s and the extraction temperature was set at 60°C. The validation results indicated that the limits of detection were in the range of 3.80-8.11ng/mL. The average recoveries were in the range of 87.32-103.12% for the two samples at two spiking levels. Compared with other reported methods, the proposed MAME-UHPLC-UV method was more effective, quicker (10s) and more eco-friendly.
[Mh] Termos MeSH primário: Catecóis/isolamento & purificação
Técnicas de Química Analítica/métodos
Cromatografia Líquida de Alta Pressão
Álcoois Graxos/isolamento & purificação
Gengibre/química
[Mh] Termos MeSH secundário: Limite de Detecção
Micelas
Micro-Ondas
Rizoma/química
Tensoativos/química
Temperatura Ambiente
Ultrassom
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Fatty Alcohols); 0 (Micelles); 0 (Surface-Active Agents); 83DNB5FIRF (shogaol); 925QK2Z900 (gingerol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE


  9 / 3558 MEDLINE  
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[PMID]:28762585
[Au] Autor:Zhang F; Ma N; Gao YF; Sun LL; Zhang JG
[Ad] Endereço:Institute of pharmacology, Taishan Medical University, Taian, 271016, China.
[Ti] Título:Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats.
[So] Source:Phytother Res;31(9):1427-1432, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ulcerative colitis is one of the most common types of inflammatory bowel disease and is multifactorial and relapsing. 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale), has been reported to improve ulcerative colitis. The present study aims to investigate the therapeutic efficacy of two analogous forms of 6-gingerol, 8-gingerol, and 10-gingerol, on ulcerative colitis. Colitis was induced in rats through consumption of 5% (w/v) dextran sulfate sodium drinking water for 7 consecutive days. 6-Gingerol, 8-gingerol, and 10-gingerol were then given intraperitoneally at doses of 30 mg kg  d for another 7 days, respectively. Body weight change, disease activity index, inflammatory cytokines, and oxidative stress indices were measured, and the colonic tissue injuries were assessed macroscopically and histopathologically. Results showed that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium, significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue, and markedly reduced the content of tumor necrosis factor alpha and Interleukin 1 beta in the serum. Histological observations showed that all three gingerols obviously accelerated mucosal damage healing. It is concluded that 6-gingerol, 8-gingerol, and 10-gingerol, the three analogues, have a strong and relatively equal efficacy in the treatment of colitis. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Catecóis/farmacologia
Colite Ulcerativa/tratamento farmacológico
Álcoois Graxos/farmacologia
[Mh] Termos MeSH secundário: Animais
Colite Ulcerativa/induzido quimicamente
Colo/efeitos dos fármacos
Colo/patologia
Sulfato de Dextrana
Modelos Animais de Doenças
Interleucina-1beta/sangue
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/patologia
Masculino
Malondialdeído/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Peroxidase/metabolismo
Ratos
Ratos Sprague-Dawley
Superóxido Dismutase/metabolismo
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-gingerol); 0 (Catechols); 0 (Fatty Alcohols); 0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha); 4Y8F71G49Q (Malondialdehyde); 9042-14-2 (Dextran Sulfate); 925QK2Z900 (gingerol); EC 1.11.1.7 (Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5871


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[PMID]:28701654
[Au] Autor:Asakawa Y; Tomiyama K; Sakurai K; Kawakami Y; Yaguchi Y
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:Volatile Compounds from the Different Organs of Houttuynia cordata and Litsea cubeba (L. citriodora).
[So] Source:J Oleo Sci;66(8):889-895, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The volatile compounds obtained from the different organs of Houttuynia cordata (Saururaceae) and Litsea cubeba (Lauraceae) were analyzed by Gas Chromatography/Mass Spectrometry (GC/MS), Headspace Solid Phase Micro Extraction-Gas Chromatography/Mass Spectrometry (HS-SPME-GC/MS), and GC/olfactometry (GC/O). The major component of all parts of H. cordata is assigned as 4-tridecanone. Each organ produces myrcene as the major monoterpenoid. The major monoterpene in the rhizomes and roots was ß-pinene instead of myrcene. 1-Decanal which was responsible for the unpleasant odor of this plant, was the predominant polyketide in both leaves and stems. The presence of 1-decanal was very poor in flowers, stem collected in summer, rhizomes, and roots. GC/MS analyses were very simple in case of the crude extracts of flowers. The content of sesquiterpenoids was extremely poor. (8Z)-Heptadecene, geranial, and neral were detected as the major components in Litsea cubeba. Odor-contributing components by GC/O analysis of the ether extract of the fresh flowers of L. cubeba were neral and geranial which played an important role in sweet-lemon fragrance of the flowers. The role of a high content of (8Z)-heptadecene was still unknown but it might play a significant role in the dispersion of the volatile monoterpene hydrocarbons and aldehydes. The flower volatiles of the Japanese L. cubeba were chemically quite different from those of the Chinese same species.
[Mh] Termos MeSH primário: Houttuynia/química
Litsea/química
Estruturas Vegetais
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Alcanos/análise
Alcenos/análise
Compostos Bicíclicos com Pontes/análise
Álcoois Graxos/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Litsea/anatomia & histologia
Monoterpenos/análise
Olfatometria
Policetídeos/análise
Sesquiterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Alkenes); 0 (Bridged Bicyclo Compounds); 0 (Fatty Alcohols); 0 (Monoterpenes); 0 (Polyketides); 0 (Sesquiterpenes); 0 (Volatile Organic Compounds); 3M39CZS25B (myrcene); 4MS8VHZ1HJ (beta-pinene); 89V4LX791F (n-decyl alcohol); A3LZF0L939 (tridecane); H7C0J39XUM (heptadecane); T7EU0O9VPP (citral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17049



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